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                <person name="Detter J.C."/>
                <person name="Glavina del Rio T."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Grimwood J."/>
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            <strain evidence="4">CCAP 1055/1</strain>
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    </evidence>
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    <sequence length="343" mass="40454" checksum="7B37E12ABCB34667" modified="2007-01-09" version="1">MSLDEKFIPLRTAFYEIIGNFFKQLAGLFGYPSNPGMPTITDFPSNVYVRSQFLDNLPIHRTFWPPIQRPETWFEMIFGPAPKVDAVPRYIYESKDEGFYNFYIENYKNIYFLPDWLSEFIQVRLHLCLDITILETIREVLFVGLMVYSQIVILRIALSWFIYINPYTFPWCYLAAAVDWTEDVLQGIVPAILGVNITGSVFLGILGVVADSLNHLVFTMPFLPSEGEETKLLINEQMKDVLVFHYLPILWYRYPVPNEIREFWYKERPDILDYMQKAYKDLDIQFLPDSIIRELNQQKLTTELFIDQNSSPNFLIESISTEMLSQSNQEFFNFILNYFEKLL</sequence>
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    <accession>B5Y3C0</accession>
    <name>B5Y3C0_PHATC</name>
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        <submittedName>
            <fullName evidence="4">COP9 SigNalosome subunit 3</fullName>
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    <gene>
        <name evidence="4" type="primary">CSN3</name>
        <name evidence="4" type="ORF">PHATR_54619</name>
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    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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            <taxon>Sar</taxon>
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            <taxon>Bacillariophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
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            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ACI65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pti:PHATR_54619"/>
    <dbReference type="eggNOG" id="KOG2582">
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="219"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="43"/>
        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002185639.1"/>
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    <dbReference type="AlphaFoldDB" id="B5Y3K6"/>
    <dbReference type="STRING" id="556484.B5Y3K6"/>
    <dbReference type="PaxDb" id="2850-Phatr46721"/>
    <dbReference type="GeneID" id="7204505"/>
    <dbReference type="KEGG" id="pti:PHATR_46721"/>
    <dbReference type="eggNOG" id="ENOG502RY9V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_1"/>
    <dbReference type="InParanoid" id="B5Y3K6"/>
    <dbReference type="OMA" id="GLHLITF"/>
    <dbReference type="OrthoDB" id="184918at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="325" mass="34750" checksum="8F79B4F087C99E50" modified="2008-11-25" version="1">MEDLSTASPILVASATATTGTATVKALSDMGASVRAMVRKVDDPRAVELAKLPGVSLIEADFDDHDSVKAMLKGIQRALLVTGAFAYEQFEREAFFIEAAHAEGVECVVRISTGSFLIKPGTKGAYGRTHHGLQAFCDVGGYPVVHLNPNWFFTNWMGSAAEARTTGTITQPVKGDGPPMAMIDPRDIGTAAATILTQTTEGLQPFLTKKYIEIHGPAMVNFADKAAALSKALGYPITINTVPREGFLQALMGMGLPRVFANSFLETIEQVDGVVPPGYEGYGPDLGRDAWPVESSPELLAVWKPQYDVNAWAASDAVQAAFKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3V6</accession>
    <name>B5Y3V6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_51007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185906.1">
        <property type="nucleotide sequence ID" value="XM_002185870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3V6"/>
    <dbReference type="FunCoup" id="B5Y3V6">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3V6"/>
    <dbReference type="PaxDb" id="2850-Phatr51007"/>
    <dbReference type="GeneID" id="7204675"/>
    <dbReference type="KEGG" id="pti:PHATR_51007"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="InParanoid" id="B5Y3V6"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="296" mass="33843" checksum="6C8B875134D22F99" modified="2008-11-25" version="1">MPASSDAASRRRQTRLRREYLYRKSLEGREKVVYEQKRVVREALAAGKPLPLEVRASYDKLKREVDSEDIKTAEVHTHVDDEYGDAGLIEPRICVTTSRSPSSRLKQFAKEIKLLFPNSTRINRGNNRVDELMESCRQSEFSDVVIVQETRGEPDGLVICHLPLGPTAFFSLSNAVMRHDLNPPAAPMSEAYPHILLNGFNSELGKRAGNILKCLFPVPRADSKRVVTFSNENDFISFRHHMYSKISHDNVALHEVGPRFEMRLYQIRLGTLEQKEADNEYTLRSFQNTSAKRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3W1</accession>
    <name>B5Y3W1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATR_28245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185725.1">
        <property type="nucleotide sequence ID" value="XM_002185689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3W1"/>
    <dbReference type="SMR" id="B5Y3W1"/>
    <dbReference type="PaxDb" id="2850-Phatr28245"/>
    <dbReference type="GeneID" id="7204560"/>
    <dbReference type="KEGG" id="pti:PHATR_28245"/>
    <dbReference type="eggNOG" id="KOG0474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_4_1_1"/>
    <dbReference type="InParanoid" id="B5Y3W1"/>
    <dbReference type="OMA" id="ILTAKWV"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="701"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACI65195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="768" mass="84633" checksum="5D26EEC78F13781B" modified="2008-11-25" version="1">MSGRPPLPKRQHSYHFSVSADALGSSSGHEGGSDHHYHEPSIDSLTYVADESDAWRAHEATQQFLHRGKFWNKGKHETTQRYFLISAIGITQATVAYLTNLSSSYFIKSKYGQVYDLLEHGHVAHAFFRFLFIQTAFAAVASIFVWIEPVSAGSGIPEVKCYLNGVDLPRVVDPKTLICKVLGVICSVSAGLPVGKEGPMVHSGAVVATTVAAGRTRNDVQKRDLVACGAAAGVCTAFSAPIGGILFALEEGASYWAPSLTWRTFFCSMIAFTTLLVLNTIGTTFGKLGFNRLFSFGNFLYEGRESSFAVYELAIFVLIGVLGGLIGAIFNNTNEKITHWRIKNINHSKKRRFVEVLLVSMLVSTISFLLPLLWGQCKALPHDPNFSESEQELVESLVPFRCVAGKEYNEVASLMFTDPGDAIRLLFHMRKHAFSFGALLLFFLSYISLAVLVYGIAVPSGLFVPSLLSGAAFGRLFGNLALRLSPNLAFSNTYALIGAAAVLGGMARMTISLTVILLECTGNEQFVLPLMLTLMTARIVGGVFNEDLYHIHIHLKKGVNFLEAELRSITRHHNLIAGHVMSPKVIFVRPVEKVGVIYDILKSSQHTNFPVIDTEDNGVLFGTIGRNALCVLLKYRAFGFPKSESSETGKGMIQNYLKLECDDEKFLPLVQWEVLEKAYPKYPSISEIRVSREDRECLVDLRPYANVAAITVPETASISRTYQVFRSLGVRFLPVVNRHNQVVGTITRPDLTPDALAEKMIGKGKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3W8</accession>
    <name>B5Y3W8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_46827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185731.1">
        <property type="nucleotide sequence ID" value="XM_002185695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3W8"/>
    <dbReference type="PaxDb" id="2850-Phatr46827"/>
    <dbReference type="GeneID" id="7204683"/>
    <dbReference type="KEGG" id="pti:PHATR_46827"/>
    <dbReference type="eggNOG" id="ENOG502RWMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355841_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3W8"/>
    <dbReference type="OMA" id="HTIMERT"/>
    <dbReference type="OrthoDB" id="49468at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="88932" checksum="4EEC604B57E6E10D" modified="2008-11-25" version="1">MSFWFDDDDPYSQKQSQSQASRLGQESEFECQTCGATESYHDSATGREVCTVCYTQSQAITQDAEMEVEDVMALAAKTKSGRLLQRRQRTGGKRGREKFPMEPLNSAVKLPDLDTCLKGMRRVFKICIERIGDLLYLEDEHRATLDQNVKGLWLAYLRSWADGAEYYGKRYPEVRISLRDQFFYAHKAHVPAIYRHLSYKAAQRIKEAEDCSRTENEEKRDPIFDSSDEEGKEEAWSEHIRSSTKKRPRTGKSTDSSILDPVLSSSSPDLVASKPTFIASGNDGKKVTFRHDTRKSTMTPMLYAEKEHLQKDFDRKDAALYSAPSMKLVLALVWTAVSRYGVSSIQILKWVYNGSLPLFNAFNFFEDKLKKELAPIASFFQMPKPPTQASLVEKSRYLLIACGLKSPDAFGGPWMEHLAASNDRRIPPDSAPRALAQIVADLGFGQQVLDIALALMGLKDAAEKSGLPQPLVFAQPDRLFTVDHLLALVACSVQFVPAWRAWKFRRPLYRSRKRAKRYVPWNEDGVRFLGNGPSLEGYLDFLDEAVFSTSNSVIPEFSNSLDYTAPPPPDHLILDNDDEDSCKKAGEEVGPCEDFLLVDFPHTAGEENFLDHLMFAIEDKLRIWSHYGREPLVLDRHQELLIDMLGYYAETDARLIHRALQDLLGTGRASRNWMKKTLRVEVRQEAKRLKTAADEKRKESKQKKGTTAARRSADQAKKGSNLNAGRKQGSVSKATIGSDLVADATQQFTSVVDDSNETVRADASRATEATATTDPPPEPLREDFKFAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5J3</accession>
    <name>B5Y5J3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">myoC1</name>
        <name evidence="8" type="ORF">PHATR_25867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186480.1">
        <property type="nucleotide sequence ID" value="XM_002186444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5J3"/>
    <dbReference type="STRING" id="556484.B5Y5J3"/>
    <dbReference type="PaxDb" id="2850-Phatr25867"/>
    <dbReference type="GeneID" id="7204087"/>
    <dbReference type="KEGG" id="pti:PHATR_25867"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249324_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5J3"/>
    <dbReference type="OrthoDB" id="46642at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="804" mass="91912" checksum="58BDDEE8B52B8077" modified="2008-11-25" version="1" fragment="single">MAELQFLHEAAVLYQIKARHASQRPYTRVGDIVVAVNPYTWIEGLYDPAQQALYANRLTLRQYPPHVYEISALAYRGMIQEGKNQTIIVSGESGAGKTETVKIVVQHLAMLEHTAPSVSVDTNPASLDIVRHVVESSPLFEAFGNAMTTKNSNGSRFGKVTRLHFAPDWTADTQDTFCYNLKGSSYQTYLLETNRIVYQTAGERSFHIFYQLLSASSDLKRTMLGEEWIDATEKDFCYLGEPRECQVDGHSDAQSFIKTLHALELFGWEGDALQSLFGALGAVLRIGNLTFQEQEEGEAIVSSDTALRLLADAVGLSTTDLESAFTHLIIKANNDTIEVPLSAEISKNTTDALAKQMYSFIFDSVVMKVNQWTASSKSSEAEAAISLVDICGFESFETNRFDQLCINYANEKLQHKYVQDNLLKKRVEHEREEIELFDTTLMDNSDILDLIEGREGLINVMNEECMRPNGNNKTFVFKLTNVHRKNARFLRKKLDRSTQFGISHFAGDVMYDASEFIERNTDKVPESLLTLFTKSSNVLIREQFVAFLQKSEEKRSTRATRKKSTVTTVLDKFRVSLKDLMLTMSDTHTRYIRCIKPNDTMSIAIADHLLTVKQLQCAGLVTAIDLTRESFPNKYSFSTAVQRFHSLMNSEQKHDLKDMKLHDKAQYMMSSLFTPLIEQYRNSDFTMPFVCGKTKIFFRSGALEVLETQRRELHFMKASILQQQIRGIQSRSNYRRMKFAVISSQAAYRGKTKRSEFRRAQQSIILLQAWARRSRTQRKYLRLKRAVVVLQMRARRIYHAHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5L3</accession>
    <name>B5Y5L3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_44178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186205.1">
        <property type="nucleotide sequence ID" value="XM_002186169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5L3"/>
    <dbReference type="SMR" id="B5Y5L3"/>
    <dbReference type="PaxDb" id="2850-Phatr44178"/>
    <dbReference type="GeneID" id="7204098"/>
    <dbReference type="KEGG" id="pti:PHATR_44178"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="B5Y5L3"/>
    <dbReference type="OMA" id="NNTWNRG"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="378" mass="43336" checksum="BDC818AB047354B0" modified="2008-11-25" version="1">MNTGHGLSSIEQVPVIDLEAEEKVLIDQIYGACSRFGFFQVVNHGINADLIDRYREQCREFFEGLDLKHKRASKRSADNARGFFDDELTKQRRDWKEALDGGMPFSRDWALPDRDPLNAGLDGYNQFPSTAILPHFRDTFVEYFQACEKLSDRLAVLMARALGAHGDEALVRDLRAHHTSYLRTNFYPMCPNENNNSIDSPLGISPHNDAGFLTVLLQDNDCHSLQVYLRETDEWSTVHPLPNALTINTGDMAQVWSNGRYQAPSHRVLTNPNQVRYSAPFFYNPGYETWVQPLQATDSGIEEPDFYHPILWGYFRAARFAGDFTDLGIEIQISDYETSRVDSSPHRQLQKVFVREGWCRRPFSADAYRELLKITQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5P5</accession>
    <name>B5Y5P5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_44204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186224.1">
        <property type="nucleotide sequence ID" value="XM_002186188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5P5"/>
    <dbReference type="STRING" id="556484.B5Y5P5"/>
    <dbReference type="PaxDb" id="2850-Phatr44204"/>
    <dbReference type="GeneID" id="7203925"/>
    <dbReference type="KEGG" id="pti:PHATR_44204"/>
    <dbReference type="eggNOG" id="ENOG502SCC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1263706_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5P5"/>
    <dbReference type="OMA" id="DTHISGY"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24625" checksum="80E3E2801EAD8B86" modified="2008-11-25" version="1">MVCCMIKSTAGPRVLGTWFSFVRATTTRQRFAFSASCGSEKLETEIQQANERYAGKISIRRASDNKGWGLFALQRFQKGSLVIRANALSESSKQDSHSVQTSWNSHVTMDLPARFINHVCDEANVGIQPNSLGAFDFFALREISIEEELTWDYETSEYEISHGFACACGAASCRGELQGFRYHGPKVLETYGVKWIAPFLLEDREDNDDDAHRLVLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNY2</accession>
    <name>B7FNY2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein translocase subunit SecA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">secA</name>
        <name evidence="13" type="ORF">PHATRDRAFT_9327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177119.1">
        <property type="nucleotide sequence ID" value="XM_002177083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNY2"/>
    <dbReference type="STRING" id="556484.B7FNY2"/>
    <dbReference type="PaxDb" id="2850-Phatr9327"/>
    <dbReference type="GeneID" id="7195980"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9327"/>
    <dbReference type="eggNOG" id="ENOG502QS7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_1"/>
    <dbReference type="InParanoid" id="B7FNY2"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17928">
        <property type="entry name" value="DEXDc_SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3060.10">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21090">
        <property type="entry name" value="P-loop_SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="12">
        <location>
            <begin position="6"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="93"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="935" mass="102737" checksum="6FFADB8E4B2D7204" modified="2009-02-10" version="1">MEDFLTGADSSKRDADNKSYLDQLQKRVNVVNSWEATVEDLGDDELEAKTADFKSRLAKGEDINGPLLEEAFAVVREAAWRVLELRHYDVQIMGGFILHDGRLAEMATGEGKTLVSTLPTYVNALTGKASFVITVNDYLARRDMEKMGQVHRFLGLTVGLIQSGMTEEQRQKAYACDVVYVTNSELGFDYLRDHLALSPKQTVLPGGAGEFDGFCVVDEADSVLIDEARTPLIISKQVPAPANKYATANQLAGALKTGIHYEVDLKNKNVVMTEQGYRESERALGVDSLFSIDGKGEAWAPFVANAVKAKELFEKDVEYTILKDSSGKSTGVGIIDAFTGRVLDGRRWSDGLHQSIEAMEGIDVSEQSKVIAKVTYQALFRQFTRLSGMTGTAMADASELEQTYGLMVTPVPTALPVARRDYADVVFKTRRAADRNLIKEVVNVGGGEPLGRPCLIGTTSVAQSEILVEALVKEGIKAELLNASPKNAPRESEIVAQAGRSGVVTVATNMAGRGTDILLGGCPTTMARIKTRSILLDRGVLSAEEKAGVPPSPSENYFPAPIDEDVLTMLNDAAASLKKAMGIELTGIELDEILTVAFDTTEAEDDLDYIVKLRDAAAAVKAVYEPVLAEEKEAVKKAGGLYVMGTNRHESSRIDQQLRGRSGRQGDPGSSRFFLSFEDDMFVIFGGDQLNRMLEMFRVSEDMPVEAQQVTDALDKVQKQVEEKYRDIRREIFNFDDVLNSQRKVIYSRRRGVLFSAPEDSLKMMKTYNEKTIQDIVKAQTDEAGSVKVDKVLEKIAQFFPLAQPLVTVGDLSGKNQNAVADLLNVAVEEVFSAKIKEMDALAKSAGNAPNSLGRSANYIALVTMDNAWSDHLQAMENLKESVILRQYQGRDPVAEYQNEAFKLFQGLEDTMRFNAVYSLWQSLATQPQAVQQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPQ1</accession>
    <name>B7FPQ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177252.1">
        <property type="nucleotide sequence ID" value="XM_002177216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPQ1"/>
    <dbReference type="STRING" id="556484.B7FPQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr42830"/>
    <dbReference type="GeneID" id="7196431"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42830"/>
    <dbReference type="HOGENOM" id="CLU_800395_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPQ1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="295" mass="33629" checksum="93C59994465D1092" modified="2009-02-10" version="1">MSSSDTARTMDILATVFFVVAGLWLIIAMLYSLMVLLFLRLRARGQLDRIYENDFGRVYLGSTSLYLPCGFILRRYLQHLQFEHTGGQQRGANGETPRHPRYMTREERRAAMEVLLSQNPSVVTPNAKYDVTEGCDDSSNRKEDGYDTDGPTCSICLAEYEPEDDVLRSQTCPHEFHRECVLDWLQRPSCTECPCCRAAMVKEDVVWETVRAARKRRRRELRKQTGTRSSILKEVRSRTSEENLEATEEESESAGNPERREAGVVTIRFGESVDDLLQESEPEDPEASDVLDGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPZ4</accession>
    <name>B7FPZ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_7108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177300.1">
        <property type="nucleotide sequence ID" value="XM_002177264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPZ4"/>
    <dbReference type="STRING" id="556484.B7FPZ4"/>
    <dbReference type="PaxDb" id="2850-Phatr7108"/>
    <dbReference type="GeneID" id="7196476"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7108"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_3_2_1"/>
    <dbReference type="InParanoid" id="B7FPZ4"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="138" mass="15236" checksum="6CA97109992197A0" modified="2009-02-10" version="1" fragment="single">LRNLVVAPLVEEIAFRACMVSALRSTTLPQGWIPVLAPLFFGLAHAHHALQMYRAGESCRPIIVQTMFQFAYTSMFGAYASFVFLWTSSIAAVFVAHSFCNAMGLPHFDFLLPSSGLYGYRILLMLVHIVGLSGFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG2</accession>
    <name>B7FQG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_9137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176866.1">
        <property type="nucleotide sequence ID" value="XM_002176830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG2"/>
    <dbReference type="STRING" id="556484.B7FQG2"/>
    <dbReference type="PaxDb" id="2850-Phatr9137"/>
    <dbReference type="GeneID" id="7196244"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9137"/>
    <dbReference type="eggNOG" id="KOG3307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_0_1_1"/>
    <dbReference type="InParanoid" id="B7FQG2"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="114" mass="12586" checksum="F84F9ED49A13ED48" modified="2009-02-10" version="1" fragment="single">DPSCGAIASFAGITRDNFQGKQVQRLSYEGYVPMAEKELRKLCDDARVEYPSVQRIAAVHILGDCPVGQASVILAVSSPHRKEAIHCVEFLIDELKARIPIWKLEVYEGDDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQS3</accession>
    <name>B7FQS3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional adapter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_1785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177456.1">
        <property type="nucleotide sequence ID" value="XM_002177420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQS3"/>
    <dbReference type="STRING" id="556484.B7FQS3"/>
    <dbReference type="PaxDb" id="2850-Phatr1785"/>
    <dbReference type="GeneID" id="7196749"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1785"/>
    <dbReference type="eggNOG" id="KOG0457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQS3"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="347"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50065" checksum="D134AD9D88BCE67D" modified="2009-02-10" version="1" fragment="single">GIFECDYCHADISQLPRIRCAVCVDFDLCLDCFTSTDHATAIAQLNSTDKYIVYDDPKFFWTVEEDLRLLEGIQTNGLGNWVEIAEAVAGQGSIGKTPRRCMERYFDDFLGRYGHILPSHTLQAEGEDEVEESDATKYSVEEFDKGDTDDTPSRTSKRRAVMMRSPSSMSTMATGAELSGFMPRREDFDVEWENDAEQAVADMEFLPGEPIEDKQLKLQVLAIYNSKLDEREKRKKFVLSRKLYDYRKTQTEHEKLPQDERDLVHRMRLFERFHTPEEHKEFLADLLKAKRLRKEIAKLQMYRRLGIRTLLEAEKYELDKERRQRDDGDMDAVQPVEDTIAIQAKLEVSSRATKEDDFAHLPGYNLLSSREVLLCQRTRLTPEQYLEVKNVLIQESLLKGLLDREGPGSSKRALVRIDVERRGDVIDFLVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQT4</accession>
    <name>B7FQT4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <ecNumber evidence="12">1.13.11.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_25000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="12"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176923.1">
        <property type="nucleotide sequence ID" value="XM_002176887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQT4"/>
    <dbReference type="STRING" id="556484.B7FQT4"/>
    <dbReference type="PaxDb" id="2850-Phatr25000"/>
    <dbReference type="GeneID" id="7196911"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25000"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090154_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQT4"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="221" mass="25834" checksum="296B91676A3A7D5B" modified="2009-02-10" version="1" fragment="single">MSDLTVAVSEPPAPQHMEPTDANKKQKMSYQMATDSDWPDAWHMPDAVEDQTKPNRLEPNVPATVDELKKIGLCYWKMDAESYEYPVKAVPWNPENATDPKLKALRDDRGYSYADIITIHPDYLPDFEKKIASFFEEHIHDAEEIRYILGGSGFFDVRNLEDKWIRIHVKKGDLMTLPEGIYHRFTCDEERIIHAMRLFIGEPVWTPFNRPQEDHPSRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQW1</accession>
    <name>B7FQW1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Tpt4</name>
        <name evidence="8" type="ORF">PHATRDRAFT_56463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177476.1">
        <property type="nucleotide sequence ID" value="XM_002177440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQW1"/>
    <dbReference type="FunCoup" id="B7FQW1">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQW1"/>
    <dbReference type="PaxDb" id="2850-Phatr43174"/>
    <dbReference type="GeneID" id="7196923"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56463"/>
    <dbReference type="eggNOG" id="KOG1442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044894_1_0_1"/>
    <dbReference type="InParanoid" id="B7FQW1"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="360" mass="39901" checksum="315290F3F9C6628F" modified="2009-02-10" version="1">MFGLDKHQMYIASVVATYWFVSINMVYLNKVLMSNKDISIPAPLFVTWFQCVVTAIICWVAGKTGERFRQSAYQQVHQEDGGIAEEAKPSFWAQFPVAEYKIGVGRRVFPLSFVFVGMITFNNLCLKWVEVSFYNVARSLTIVFNVFLSNALLGSSTSSKTMLCLGLVILGFFMGSQGESNFSIYGTVAGIFSSLFVSLNSIYTKKILPAVDNDHWRLTFYNNINACILFLPMILVFEHQALAAAVNQQFLSGIFWSAMSVAGFFGFSIGIVTVLQIKATSPLTHNISGTAKAAVQSMMAFYIWGNEATLMGVLGIFTVLGGSLLYTFVKMSESKANSTPRVAEQKTDVEMQKPNNKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRX1</accession>
    <name>B7FRX1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_54080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177873.1">
        <property type="nucleotide sequence ID" value="XM_002177837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRX1"/>
    <dbReference type="PaxDb" id="2850-Phatr54080"/>
    <dbReference type="GeneID" id="7197392"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54080"/>
    <dbReference type="eggNOG" id="ENOG502R0Y7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633819_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRX1"/>
    <dbReference type="OrthoDB" id="45663at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="entry name" value="Holliday junction resolvase RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="Holliday junction resolvase RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854941" evidence="2">
        <location>
            <begin position="18"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="386" mass="43149" checksum="835D4A0903E83D55" modified="2009-02-10" version="1">MRVLWLQSIHAAAVVLASEPRWVRKGQNFHGSAFCPAPSIAVLRKTSVRYKEQVYFGVHEEILCRRCKDSSTLLCMSRDKKTPTALDTTPVMEDFSGSRKIIPKPATKGSKKQITDSKQRLIAKEKKVVKKRLSTKGKQKTITAKENDSSLLTSKQKTTKRASTTDKGPLHWRSLDDVVLFKPHGCVVVVDDDDNEPTDIFSNVTGRVAFTVRGNPLPLRRHRTARGFVYNPSAKAQESFRDIVSHMVTGFRDELHLLKGTHLPIAAGVPFFPEGQALVMTILFSMKRPNNHFVANRRGMLEDGCRLKATAPSVTSPTRTDVDNLAKFVLDSCNGLLYEDDRQVISLHVTKVLDEQGTCLGSTQVDLRAVRDDEIPLLLNRSFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS22</accession>
    <name>B7FS22_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_56624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177904.1">
        <property type="nucleotide sequence ID" value="XM_002177868.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FS22"/>
    <dbReference type="GeneID" id="7197121"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56624"/>
    <dbReference type="HOGENOM" id="CLU_261496_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS22"/>
    <dbReference type="OMA" id="FFAEFLM"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="459"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="664"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="731"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1080"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1301" mass="143064" checksum="20C267EDC66A5E07" modified="2009-02-10" version="1">MTADAKPSLPATEESPAETELRSRLARTIQLRATTQLELRKSQKELERLLVAIPPRPRQPLADVNEQLRTLETYRETHSLSLAEEKALLRRIHSLEAARCVCNTYTAADVAIRCEKALTASLRGSLQSQTQQIAALRDTLQTTRTARKLGCDVAELQKVLVDCPPAQLGRVIGKDGSNVRAWMQKYGVTIDVDRERHQLALKGSHQALECTLPAVQRIVDTTERDLSTLVSTSTVAYWTTKHITALEDLRSRYSHVYIDIQRGKHQKQHLVRLRGIPVDLDSVQHEMELWRIVTKTVAVDAAAASVILGKKGNNITRMVQTHQVTMDVRNPSGSASNDHSNETNSMSTTATTKMEITGPVDNVTAAVQEIEQIMADHERVVKTVPVDRNVQEVFLHQSGLGIKATHKVINDAIQTIAPGALPVNVGDKGDQGGSIVLRGKAMYMETAVSMVEKEAARVQNLIVQIRVDPLVIPLLIGPSGTNIRKLMQNHPAATLLIDRDGGIVTIGGLEAAPIQALQAEIEAMVRDNQLERVKLDAQTYHSVVAAVLRSSKIKEMNKLNIKLFTQDDTNEIVLRGSAESLPQAASLVRDVISENYIAELAVDVDDLKVLLEGGKKSPIVEFSNSFGVQLSSNRETQVVTVRGPQDRVNEATAAVNSFLYGGEGHRVAKIPLNRDGAGVVIGRGGKTRIDLEKKYGVTVQVHRTNDHVTVRGTADAVEDCNLEIARLLLTASVVESLDVSEEQSKGLISARLAALIQKTVPVRISVGETKVTVRGCRHDVNDAVALLKEQLYGIYEGRIVLDIDYFHKMQDACKDLSHFTRIKRNSGVELSVDESAAAIVVTGQREKVKGAKLQLFSLFGFIFDSSFTQLAVPPASLSTIGQVAVLAEVSSASGGASVLLDRDTHAILIFAQEASKVSKAKNEIEKRMQLSLSRLHVIELESSEDWLVATTIGKGGKNINALRKRTGCSIDVDSTKRKIVISSENEQSFDNGRKEVEDFLEKERQRCVFCEIPEQYYPAFVGRGGANIKKFSETHNVNIQTMRNTPVKGLRITGEKDFVAAAKTAIQEWIAFRQQAREEADMSESMPLRHDQISVILGTKGSTVRSLQSEFGCRVNVERQSPCCVLVQGGSPGKRQATLAKIRELLLSDAVLKSENLERSNDPGSHFIEMAVQSQSKVHREQVPQTQRNVKKKGVSSWTEYFPVLDSGADEQKTETSSTSTFIENTKNESPSWSTIVQIPTMAGEISNDVKQRRSFVSMVSDDDWDATSVGSDPADHQLNAELRYESDACTKVAQLMGNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSF3</accession>
    <name>B7FSF3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_8451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177653.1">
        <property type="nucleotide sequence ID" value="XM_002177617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSF3"/>
    <dbReference type="FunCoup" id="B7FSF3">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSF3"/>
    <dbReference type="PaxDb" id="2850-Phatr8451"/>
    <dbReference type="GeneID" id="7197192"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8451"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_1_0_1"/>
    <dbReference type="InParanoid" id="B7FSF3"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="76" mass="8577" checksum="55E9E2A235B6EB49" modified="2009-02-10" version="1" fragment="single">VFVGNLAFNTTEEQLQQVFSDIGRVIHVRLVTDVDTGKPRGFAFVEFSDAQAALSAIRNMNDYELNGRRIRVNFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSN3</accession>
    <name>B7FSN3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_32797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177695.1">
        <property type="nucleotide sequence ID" value="XM_002177659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSN3"/>
    <dbReference type="PaxDb" id="2850-Phatr32797"/>
    <dbReference type="GeneID" id="7197300"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32797"/>
    <dbReference type="HOGENOM" id="CLU_1067358_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSN3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="261" mass="28084" checksum="F689DD4577CC18FA" modified="2009-02-10" version="1">MNVNSKLAETRKLFPAEDKDVTYGTTTKLTCAVCRGAKSASDHLCSQCSDALYEIASDDYVIKDTQYQERHCYATPGLAQRDQRCAKANPSAALEETTAGAASPIVQIECRGTKRRLDIGENPFLSQAEDQDLVLTVKVKSPSSAVRQKFLDAKQNGAVIELMSPGREFISSNCVITAIEGIVAETHSHSQSDAQSVCSGSDLSVVVTDVRTVDECISERLRAAEVAGTVTYVDSSSPKDPEHLPLCVYCDGARSGENPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FST5</accession>
    <name>B7FST5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_32849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178037.1">
        <property type="nucleotide sequence ID" value="XM_002178001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FST5"/>
    <dbReference type="STRING" id="556484.B7FST5"/>
    <dbReference type="PaxDb" id="2850-Phatr32849"/>
    <dbReference type="GeneID" id="7197325"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32849"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_4_0_1"/>
    <dbReference type="InParanoid" id="B7FST5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32306" checksum="2C567DE11C64B7B6" modified="2009-02-10" version="1">MWVNTVQVHESQEPSYSSDAIEPMSKLHLSPSETVLNYGQALFEGLKAFRREDGSIVMFRPQMNAARMQQGARRFLLPPVPTDVFVKAAESVVRANARWVPPHQKGALYLRPLLMGTGAGLGVKPSTETTFCIFCSPVGNYFKGDLKAIRLQAVRGYSRAAPGGSGAVKATGNYAPAFLAQKRVKERGFDEILCLDAVTGEAVEEAGASNFSAIFPNNTIVTPTLDTETILPGVTRESIMELAKTECGYKIITGRLTLDDLREAREAFCCGTGAVITPVGCVSILNGERNEDMIILGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTW9</accession>
    <name>B7FTW9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_18927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178495.1">
        <property type="nucleotide sequence ID" value="XM_002178459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTW9"/>
    <dbReference type="PaxDb" id="2850-Phatr18927"/>
    <dbReference type="GeneID" id="7197849"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18927"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="InParanoid" id="B7FTW9"/>
    <dbReference type="OMA" id="NWAVGIP"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="33100" checksum="8879D906632F4D46" modified="2009-02-10" version="1">MTTKETYAMPNDEQYEMPTEQAVAKKPDSALKSFLSGGVGGICVVVVGHPLDLIKVRMQTGGIAGASGSVLGIFANTFRSEGMRGLYRGVSAPLLAVSPIFAISFWGYDIGQRLVQYVQPSPGDLSLTQKCVAGGLSAIPTTAIMAPSERIKCLLQTNGDKYKGMKDCATAIYREGGFASLFRGTGATLLRDVPGSMAWFGTYEAVKMGMMKAQGIEDTSQLSPSAVLTAGGLAGMACWVISIPADVLKSRYQTAPEGMYRGLGDVYKKLMAEEGAGALFTGIRPALIRAFPANAACFFGMEVARKVFSFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTX3</accession>
    <name>B7FTX3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178498.1">
        <property type="nucleotide sequence ID" value="XM_002178462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTX3"/>
    <dbReference type="STRING" id="556484.B7FTX3"/>
    <dbReference type="PaxDb" id="2850-Phatr44384"/>
    <dbReference type="GeneID" id="7198052"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44384"/>
    <dbReference type="eggNOG" id="ENOG502RRMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379708_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTX3"/>
    <dbReference type="OMA" id="FIANDQI"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855320" description="4-hydroxyphenylpyruvate dioxygenase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="730" mass="80829" checksum="CFF4CA0C2E6484FC" modified="2009-02-10" version="1">MVTNNAFKLRRASLLFTLLGSTSKFASSFSVTIKQVSTIGMSSTTTTAASIDPATLQPQQSEAVCFSHIHLYVDRLENVNVYKDLEDRLNQFAGKVASSAVTPSLAEKQAIWKSISGNADSSNENDNTVYQPQNRDVVKQLLAGFGFRVTGTCYPEEGSSNTRSVLVTSRDPRGVQILISAVDHDTSEATPHRYPYFDAKKINNFYAAHARRQGIGALAFRAPNVSSIFERYQSLHPTLVAGYHEFDEAKILEVFAYYKSHELDSLTKEPDTGTVLRFVQTSASTSVCPLPGLKTLDATFEDSSLAAYCDHWVSNVFDRTEFLDTLQDTLGFTPKVDFNAGVVAAGEAQIESTVTGNEFPIVPSNKAAALSDQSQVYLPINNALSSVGHVHGFLQELGQGVQHVASRVEDLVEFVQRANDYRCYTNEGFTFLRIPRSYYGILTVAQLTEGIDGDESGVGQSCAEKIFAALKAASFMTPDGALNLECEKEDIARILKHSLTDSVLSEYHTMQDTVLAVILRSRYRNVYSLLRDQVSETTYLGIVRNQILVDVQGEDLLYQIFTSNVLQREAGQEAPFFEFIQRVCSKSTDKHGDPVKIRPGCGGFGIRNFLTLFLSIEVSKAMNDVADAVATGNTKREAYARAMVESFTDQLNEANPILTFISDAMTEEGLCKEKLLDAIAENNSRQAKKWTTQMELVAERKKKGNEMLMECSARYNSLMRSLREAHINER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUF1</accession>
    <name>B7FUF1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178311.1">
        <property type="nucleotide sequence ID" value="XM_002178275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUF1"/>
    <dbReference type="PaxDb" id="2850-Phatr44530"/>
    <dbReference type="GeneID" id="7197786"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44530"/>
    <dbReference type="eggNOG" id="ENOG502SJDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411900_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUF1"/>
    <dbReference type="OrthoDB" id="47682at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="685" mass="76520" checksum="017D48420323DEA8" modified="2009-02-10" version="1">MASAKLSRGKKWRWRLVVMAILASLALSVVRRLFFQERQTVQWLPPLAIENPTYFSAFEEERMPTSSSDEACQTPLVEDTKEDSRSELLVDGSDFAAAARARTSSHPFCQRFRYEQSASALWSSHREAIMNKTNHANDEDGRHRPWIEKLFDTVSPFLLQRGLRNPPNAADTKRVLNIVETKLANSSAPPLYVAVFGGSVVEGTNCDFIPPAALELVTNRSLLRERKRNMYDTVIKGRSCTWPNRLQALVDYALGEGVVKIYNLGVGGTNSQLAVPIVKYRLYSGAADLVNIGGPDVVINGYAVNDNAYFSSTAATATYTHFNASLARAEDFIRAVWKSRPCHDPPMVWFFDEHFGNYIESLLGEDIQKDAVRLLADYYELGYVSSSFSVRSFFLSDPDETLFSPDWEDPVKKSRIVDGHFGMPGHVHASWTFAYAALQTVLDYCADHAFTDSISTIRLQDGQFTSQLADMQTLLDRTYLPPPLGQDTLSLVNIAKTWRATQQQQYRSEKLLCEDEMNTQGTLCPLAFVATPVGTTRQARAVDDYLKPFVTVNTGWYGRNDIRNGWQNKIGLMPTGIGASIILSLEHVTTLIQMISLQTLRSYGDPWEGSEALFDLTIIRGNPNSTDFRDNFTIPAYHDANMSVSYLYEHDLGKNRAVAGDSLTLNITLVAGSAFKLIALMMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUP3</accession>
    <name>B7FUP3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amino-acid N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_10902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ArgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178357.1">
        <property type="nucleotide sequence ID" value="XM_002178321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUP3"/>
    <dbReference type="STRING" id="556484.B7FUP3"/>
    <dbReference type="PaxDb" id="2850-Phatr10902"/>
    <dbReference type="GeneID" id="7197620"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10902"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024773_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUP3"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01105">
        <property type="entry name" value="N_acetyl_glu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01890">
        <property type="entry name" value="N-Ac-Glu-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003641">
        <property type="entry name" value="PRK05279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602:SF12">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE NAGS1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000423">
        <property type="entry name" value="ArgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="331"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="473" mass="52967" checksum="F3A4969B93FB5EE5" modified="2009-02-10" version="1" fragment="single">KRLPFVSMFRGSANYIANHRNTLAVYHIPGGLLDQPGNNVFRDLMNDIALTWLLGMKIVLVVGCRHQIAKRVAQHQSDSSLEENLQSRHGLRVTDEKTLRIVKEEAGYVRFEVERQLARSLRMQGGGMGNAPGVGSTGQGYYDGNVVSGNFYSAQPFGILDGVDFKYTGFVRRVEVEWIRQKHNNRDICLMTTLGVSPSGEVFNVNSEALAASVAGALEASKVIYFTEQEMELRHTQHGKKIQSLRMSDANNLLEYSGVTIHKKGFVQLDDELHEMDKAALDMLLKIGWSVQALEMGVKRAHIISPKHGALLQELYTRDGSGLLISGDLYDGIRRANVHDVAAIHDLISPLIQMGTLIDRPKSVLEKDVESYYVFTRDNHIVASGQLKIFENGFAEIGCLVVNQGYRSRGRGDAMLGYLERLCLVNSCSSIFVLSTQTMEWFVERGFDEVGVDRLPPSRQATYNYKRNSKIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV03</accession>
    <name>B7FV03_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSP</name>
        <name evidence="12" type="ORF">PHATRDRAFT_19244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178686.1">
        <property type="nucleotide sequence ID" value="XM_002178650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV03"/>
    <dbReference type="STRING" id="556484.B7FV03"/>
    <dbReference type="PaxDb" id="2850-Phatr19244"/>
    <dbReference type="GeneID" id="7197905"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19244"/>
    <dbReference type="eggNOG" id="KOG1615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_2_1_1"/>
    <dbReference type="InParanoid" id="B7FV03"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="242" mass="26050" checksum="3F718FCE3029BA89" modified="2009-02-10" version="1">MNIPSSIDLPTPPIGQNVEAAIQALLRADAVCFDVDSTVIDEEGIDVLAEHLGKGQQVSELTLAAMEGGMKFQEALAARLNLLEPSQQAIMECLEAHPLKLTSGMADLVQVLADQGKHVYLVSGGFRIMIEPVADVLGINPRNIYANTILFDDAGKYAGFDTNEPTSADMGKPKALEIIKKLGNYETMIMIGDGATDAQAKPPANAFIGFGGVAVREKVKKVADWFVTDFSDLLQVLQYNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVE9</accession>
    <name>B7FVE9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178918.1">
        <property type="nucleotide sequence ID" value="XM_002178882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVE9"/>
    <dbReference type="PaxDb" id="2850-Phatr44724"/>
    <dbReference type="GeneID" id="7199858"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44724"/>
    <dbReference type="eggNOG" id="ENOG502S4QX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147699_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVE9"/>
    <dbReference type="OrthoDB" id="497128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="141" mass="15839" checksum="7FEA9F5A7C454DA4" modified="2009-02-10" version="1">MMLAGLSPHTFRHIFSRTAQIAANYNSRTMNTITEGVQFDTIAREWRCKWSVSDDKKSLQEAQKALESVLADVKKVEGVKDVQRVVCGGCLDFKVMTSLPADKFGAWEEAKFAPEEDFLGKLKEIDGISTIETQTFTLMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW38</accession>
    <name>B7FW38_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentapeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_11235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178816.1">
        <property type="nucleotide sequence ID" value="XM_002178780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW38"/>
    <dbReference type="STRING" id="556484.B7FW38"/>
    <dbReference type="PaxDb" id="2850-Phatr11235"/>
    <dbReference type="GeneID" id="7199607"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11235"/>
    <dbReference type="eggNOG" id="ENOG502S4CZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066336_1_0_1"/>
    <dbReference type="InParanoid" id="B7FW38"/>
    <dbReference type="OrthoDB" id="9989223at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044213">
        <property type="entry name" value="At2g44920-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47200">
        <property type="entry name" value="THYLAKOID LUMENAL 15 KDA PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47200:SF2">
        <property type="entry name" value="THYLAKOID LUMENAL 15 KDA PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11740" checksum="2C123074A0B07373" modified="2009-02-10" version="1" fragment="single">IAKSTNFGKSNLKGCRFYKAYLVRADFSGADLRGASLEDTSMDEALLKDTVAVGAYFSASIMDTLTVENADFTDAQFPIKTLPLLCERSDATGTNPVTGVDTRESLMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWS2</accession>
    <name>B7FWS2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179212.1">
        <property type="nucleotide sequence ID" value="XM_002179176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWS2"/>
    <dbReference type="PaxDb" id="2850-Phatr45186"/>
    <dbReference type="GeneID" id="7200225"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45186"/>
    <dbReference type="eggNOG" id="ENOG502SVDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2311625_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWS2"/>
    <dbReference type="OrthoDB" id="45951at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852721" evidence="2">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="157" mass="17349" checksum="F8C7F988D0EAD1CF" modified="2009-02-10" version="1">MLSSRIFLAALFLLFFFSGTSAWSTNQKVFRSSTPQRRKKDPTTPTASKPAHITAQNMLKNPGTPRVNEAPRKSRTKLSNSVLASCDTLPSFPTAHGLLSPETVMRMEELTDDGNRSPAVLSFLKTYRKEGPLSCLPMLSDPDVLPHLTEAMRDIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX10</accession>
    <name>B7FX10_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179473.1">
        <property type="nucleotide sequence ID" value="XM_002179437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX10"/>
    <dbReference type="PaxDb" id="2850-Phatr45255"/>
    <dbReference type="GeneID" id="7200268"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45255"/>
    <dbReference type="HOGENOM" id="CLU_578074_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX10"/>
    <dbReference type="OrthoDB" id="10682033at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="473" mass="54702" checksum="363EF6A6196F0271" modified="2009-02-10" version="1">MAGTRLIIQVSFLIPYVALLAAAVYWGLFDDLLLVPLVRQDGRPVLSRASLPPATLARLPPVRLATIETQTFFWEQIVKQRLPWQSVPPATRLWEVLESPHALHLSLCQDPWSVLDMEPYESFADVWICESPPPQRHDHPRIVVRRRTLIFYPTNLQHREREWALILPAIETSQQKLEKELHLTVWVDPYHTSAVEVVERIEQWRSQQGWSDWPCLTSTITDVRVVKNGRKTKMLNVDQIFQVLANDFDSRKRRSSEHLYLWFYATTNQENTTLAVVDEAVSNLFLTTLANTTTYNEKVSFVSMHHRINDWLGSSCLGMPMMDSSGIDWEADESSNVPNLYTTLWFHALLPTKYAEIFSNMQATKQKLLETPRTVRLTSHGIAEDWNGISRTLQKANQAAENGHFARVLSHLNEADLRWRNLQRDPAWLEPLDFPWDQYAAIFAPLLLPTMLPAILGLGREYKRYRRLCSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX12</accession>
    <name>B7FX12_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179475.1">
        <property type="nucleotide sequence ID" value="XM_002179439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX12"/>
    <dbReference type="PaxDb" id="2850-Phatr34905"/>
    <dbReference type="GeneID" id="7200270"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34905"/>
    <dbReference type="HOGENOM" id="CLU_2215094_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX12"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="107" mass="11938" checksum="52106BFB79A1B599" modified="2009-02-10" version="1">MLKKKNPVSTHPAPANIPLHHVHHDMDLSKESFHEIFLQVMAEYPDDDDRHIDAPTQDTRRSSDSNTTSPLPSDVVVGRRPSCGSVLPEILRAHAEAYTATARTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYL5</accession>
    <name>B7FYL5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_35472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179951.1">
        <property type="nucleotide sequence ID" value="XM_002179915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYL5"/>
    <dbReference type="STRING" id="556484.B7FYL5"/>
    <dbReference type="PaxDb" id="2850-Phatr35472"/>
    <dbReference type="GeneID" id="7200481"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35472"/>
    <dbReference type="eggNOG" id="KOG4058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1216800_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYL5"/>
    <dbReference type="OMA" id="PPIMERM"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="228" mass="25260" checksum="6A232A64B7CADD26" modified="2009-02-10" version="1">MKETDEITAALDELGISASDLGGPDKDSPPTKLHPIIAFGIGAFCVANLGLLMSLPPVLRGKGAPYLPTFQKNLDAMFRQLRQQPHFQKQIRDGTKLTFVDLGSGDGRVVFRAAAENLFVKSTGYELNPLLHLLASGRRWVGGPRQWELTTFYCSDLWNVDLRRANVVTVYGLGPIMKDLGTKLENELSPGSFILSNVFTFPGWKPQSSQGGTYIYRTPNCWQSENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYY0</accession>
    <name>B7FYY0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180247.1">
        <property type="nucleotide sequence ID" value="XM_002180211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYY0"/>
    <dbReference type="STRING" id="556484.B7FYY0"/>
    <dbReference type="PaxDb" id="2850-Phatr12379"/>
    <dbReference type="GeneID" id="7201100"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12379"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYY0"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="20182" checksum="1E767CCF3F07AE6D" modified="2009-02-10" version="1" fragment="single">WAAYNDALDSKPLFTKAMTSLVGWGLGDVLAQVRFDSRAQSMDQFTGKLSFRTRFVTLSVFGFIYHGPSGHYFYNWLDGKIKGTRAQDVALKVGIDQILWCPIFMTVFFTYLGLCNGDSFNTIGNKIKNDLLSACQGSWKVWPIVHAVNFKFISSKHRLVFINAVQVAFNMFLSLIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ42</accession>
    <name>B7FZ42_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_12420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180281.1">
        <property type="nucleotide sequence ID" value="XM_002180245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ42"/>
    <dbReference type="STRING" id="556484.B7FZ42"/>
    <dbReference type="PaxDb" id="2850-Phatr12420"/>
    <dbReference type="GeneID" id="7201128"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12420"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZ42"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052987">
        <property type="entry name" value="Chloroplast_AMP-bd_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43813">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 16, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43813:SF1">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 16, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="633" mass="69103" checksum="48EABF12879BA131" modified="2009-02-10" version="1" fragment="single">LIGKLHTMRDTLRNCPQLWTELSRNCGDKRALLDEHMCDDKVDVTFAEMNTIVRKSAAVFQSLGVKPGVNVAILGENSARWLMVDHGIQMAGGASAVRGADAPLDELRYIYEQSDSAGIVVVQGPKLLEKLASDASAKGMHRLGEELTKMVDKYGLTVRVFADLLEEVQPVTDEQIPVLGRDDLATIVYTSGTTGRPKGVMLTHGNLIHQIGHRVGTETRYDESEPLPDETMLSLLPVWHITERSFELWMLARGCNVVYSSIRTFKNDLAKHRPEWAVLVPRVLEKIATGVQDKFSSGSLPVKLLSKLFTSTSKAAAKHRKITQGYVVGEQPPGAMEKLASKALLVALSPLNAVGNKIVWSKVQNGFGGRMRTIMSGGSALSGSLEEFYEAAGLTIIVAYGLTECAPLISHRRRDANLVTGGCVGTACIDTELRVVSPESKASTTPRPALPAGEVGVVIARGPQIMKGYYKDVAETKKAIDQFGFFDTGDLGRVNPATGDLILTGRAKDTIVLSNGENVEPGPLEDAILGELSLIEQVMLTGQDGRKLTAIVVLSPSELANEGFLSKDEGALMQKRNEQVNDPKSTKRFQKWEQVKDVYVTLEPFAMANGQLTQSYKVKRPFVLERYEDELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZY7</accession>
    <name>B7FZY7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_46074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180583.1">
        <property type="nucleotide sequence ID" value="XM_002180547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZY7"/>
    <dbReference type="PaxDb" id="2850-Phatr46074"/>
    <dbReference type="GeneID" id="7201424"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46074"/>
    <dbReference type="eggNOG" id="KOG3696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728563_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZY7"/>
    <dbReference type="OMA" id="RYILMMR"/>
    <dbReference type="OrthoDB" id="438431at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="5">
        <location>
            <begin position="138"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="380" mass="42555" checksum="DD532ADA2AB7A817" modified="2009-02-10" version="1">MPRWHVIGRVMAVAVGFEATSSGAFSVAPRRRSSPRSFPLAVRPSSTTAASLPQTTPLPKHTFAGMVEHGIRERFGDHADRVIESWRLLDQDYEHQEFVGSGDPETSNCHQWAHSYVPGLSIQEFWDTAEFGWCQRLESKYKAIRKEFLAVTADMERLTREGNNVWAGALTEDASSYGEGWKTLVLMNRGRWDPVNVNLFPVTSQAIHDCHVPAAEVFFASMKPNSAIQRHSDFTNFVLTSHLALDIPYSGQNKCRLTIGDTTREWINGQVSMFDTSLMHDAVNEADQTRYILMMRVWHPDLTEAERNALQFTFDCLETPELVSEDPGQRFLAEREVQASRSFPQIKRDVSRVVGFGGKAKGGAKKNKAKASTGGGRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZZ2</accession>
    <name>B7FZZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(d)CMP kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180587.1">
        <property type="nucleotide sequence ID" value="XM_002180551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr46077"/>
    <dbReference type="GeneID" id="7201425"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46077"/>
    <dbReference type="eggNOG" id="ENOG502QXKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063153_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZZ2"/>
    <dbReference type="OMA" id="AATWCEQ"/>
    <dbReference type="OrthoDB" id="416765at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37370" checksum="9EE06CCF662D0D36" modified="2009-02-10" version="1">MDLFLFTVSAAAYRYHIGWNKTKFFRGISYATLSKQNAETSTAILRHFAKSSVFGRLASYEGALTVQRDVEDGEKLEIGIEFAKKKGVIDPDFTPEPYITIDVLGKAPAEVASIILQHVGQQASGVIVLVGLSGTGKGTTVALLRQTLEQDQGKQVVTWSNGNVFRSVTLLAATWCEQQPGIDGFDATKALTKGNIANYMKMLTFGKFNGKYDIRIHGLGLDVLVSEVQNTTLKSLAVSKNIPTVAQFTQGEVILFAAQAVETMGKDGIFVLLEGREQTVDYVRSPHRFNLTLSDPTLIGKRRAAQRLMGSAVGSVPKNAAPVIIQQAMEDALHDMVKEIESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G025</accession>
    <name>B7G025_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180605.1">
        <property type="nucleotide sequence ID" value="XM_002180569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G025"/>
    <dbReference type="PaxDb" id="2850-Phatr46100"/>
    <dbReference type="GeneID" id="7201440"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46100"/>
    <dbReference type="HOGENOM" id="CLU_2008381_0_0_1"/>
    <dbReference type="InParanoid" id="B7G025"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="124" mass="13945" checksum="43CA6CCB0BB74E75" modified="2009-02-10" version="1">MGAACGKSAGAEVEQEESTLSVMFKRIDKDNKGYISPTDLKEMMKDDKTHFQGKDADHIMAKYGTDNKMNVAEFRQWWNSTYTTYNDDALGKIVEEVNEEISPLEAIPELPEIPHNSNVAISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G027</accession>
    <name>B7G027_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tocopherol o-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMT</name>
        <name evidence="6" type="ORF">PHATRDRAFT_20470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180606.1">
        <property type="nucleotide sequence ID" value="XM_002180570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G027"/>
    <dbReference type="SMR" id="B7G027"/>
    <dbReference type="FunCoup" id="B7G027">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G027"/>
    <dbReference type="PaxDb" id="2850-Phatr20470"/>
    <dbReference type="GeneID" id="7201441"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20470"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_0_0_1"/>
    <dbReference type="InParanoid" id="B7G027"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="4">
        <location>
            <begin position="150"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="318" mass="35818" checksum="8C2A0049F26743D1" modified="2009-02-10" version="1">MVSSLSKAVKRVKDSISSKERSREDLKVGIAGFYDRSSQLWEKVWGEHMHHGYYVPENRTDHVQAQIDLIDEVLKWASVDAPAVKRAVDVGCGIGGSSRHLARKYNCVTEGITLSPYQANRGNDLAAEQGLTDQCNFQVADALDMPFKTGSFDLVWSLESGEHMPDKKQFVNELFRVARPGGRIIIVTWCHRDLEKGETSLTKSEMKLLKKINRAYYLPEWCSVQHYVDLLEAKGATDIRREDWSYIIAPFWKAVIKSSLNLRSVWGLINSGFSTQRGAYAMLLMLRGFNKGLIKFGLLTCTRPEGPGTPADSLKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G051</accession>
    <name>B7G051_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_12887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180617.1">
        <property type="nucleotide sequence ID" value="XM_002180581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G051"/>
    <dbReference type="STRING" id="556484.B7G051"/>
    <dbReference type="PaxDb" id="2850-Phatr12887"/>
    <dbReference type="GeneID" id="7201454"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12887"/>
    <dbReference type="eggNOG" id="ENOG502S0ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338747_0_0_1"/>
    <dbReference type="InParanoid" id="B7G051"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210:SF1">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21608" checksum="4468DE1531ECBAF9" modified="2009-02-10" version="1" fragment="single">CYMCFDEEDSEENPMITPCKCSGDTKYVHVDCLRKWHTAEADNQICFLSSVDATCSVCKSTFKSDFKLKDGRHLKLFKSSLEPPYVSLLVATKHEMAQRLFNTRFQLSFSTLMKPDGKNATRPLLLGRSSGSDMVLDYRTVSARHASIRFKNGEFIFTDGGSSNGSYLYLRKPLELSPSQAVQFRLGRSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G099</accession>
    <name>B7G099_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_27659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180438.1">
        <property type="nucleotide sequence ID" value="XM_002180402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G099"/>
    <dbReference type="STRING" id="556484.B7G099"/>
    <dbReference type="PaxDb" id="2850-Phatr27659"/>
    <dbReference type="GeneID" id="7201376"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27659"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_1_1"/>
    <dbReference type="InParanoid" id="B7G099"/>
    <dbReference type="OMA" id="EHKRINT"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17948" checksum="74CC2203A348A487" modified="2009-02-10" version="1">MKKRINFRKLGRTSSHKWAMLRNLVTSLIEHERVVTTLPKAKEVQSLAEKLVTTAKKENKLHARRKINEIVRTATEQTKLMTVLGPRYAFRQGGYTRIMKLAKPRAGDKADMAVLEYVDRPGEIRAARPPAALRNESLESIMEKLGLQAKEELEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0I4</accession>
    <name>B7G0I4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_20608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180684.1">
        <property type="nucleotide sequence ID" value="XM_002180648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0I4"/>
    <dbReference type="STRING" id="556484.B7G0I4"/>
    <dbReference type="PaxDb" id="2850-Phatr20608"/>
    <dbReference type="GeneID" id="7201190"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20608"/>
    <dbReference type="eggNOG" id="KOG1067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_1"/>
    <dbReference type="InParanoid" id="B7G0I4"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02393">
        <property type="entry name" value="KH-I_PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11364">
        <property type="entry name" value="RNase_PH_PNPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008805">
        <property type="entry name" value="PRK11824.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852831" description="polyribonucleotide nucleotidyltransferase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="705"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="830" mass="89450" checksum="D058122B0BC2714B" modified="2009-02-10" version="1">MAFNMKFLALFLTFFQGEECWAFHPIASFRSGRSGRKGVDGSASTSSRWASDGSGTAFSIESDHSGPAGFPVHRVIFHSLPGQEQDVPPICIETGKIGRQAAGAVTLTRGDSVLYATTSHDKDPKEEIDFCPLSVDYQERFSSAGLTSGGYNKRDGRPAEHEILTCRLIDRPLRPLIQSGWRHETQLLSWVLSYDGERSCDPLAIIASASSLFISDVPLHKPVAAVQVGMKDDGTLVVNPTNLQMETSKLNLMVAGTEEAVLMIEGAADFLPESTMIQAVKTGHEAIQVLCQGLTALGKVAGKEKKLDTIKATPENLQIRVDELFSDRIDDMWSSGLGKEAQGKIMTDLYTAVVGELIEDYPGETVAIKGAFKDLLCRRMFFRAREEGLRCDGRGPTDIRQLTMETGLLPRVHGSALFTRGETQCVATTTLGGSGMRQKIEKLDGTDEKRFYLQYTFPPSCVGETGRVGAPGRREVGHGNLAERALIPTIPALADFPYTIRVESLITESHGSSSMASVCGGSLALMDAGVPIKAPVAGIAMGMLLGDKGGVSDENAVILSDILGTEDALGTMDFKVAGDRVGISTFQLDIKCEGLTLETMESALEQARTGRLHLLSEMEKVIASPREELPATVPKMMSFSIPVEAIGKIIGPGGKQIRAIIEDFELVNMDVGEEGGVQLSSFDTAKMGEAQTFITTLVRPEPVEGETYTGKITGIHPFGVFLEILPGAEDGSYPGLEGLVHVSELAHERVRNCEGFMKSMNVEELTVKYLGKDKGKLQLSRKALLEEQGGDGGRRNGSRGPSREAAAPTPEMTKDEIDVIAQAIEGVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0U2</accession>
    <name>B7G0U2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180541.1">
        <property type="nucleotide sequence ID" value="XM_002180505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0U2"/>
    <dbReference type="PaxDb" id="2850-Phatr46323"/>
    <dbReference type="GeneID" id="7201506"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46323"/>
    <dbReference type="HOGENOM" id="CLU_759656_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0U2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="333" mass="34622" checksum="CF7BF9A8C19BA5C6" modified="2009-02-10" version="1">MGCGASTEAAASATPVPTTKTTVSASASRNLPSPTSKTDDSKRESAGDVTGEECSSELEKIRVEAPHERVTADLSSVPPPSSSKAVAVEPSAAGPKETSDLSSVADSVQGTVVTSNTTTQLMDVAEATSLGSIVKNATFPETEVPIESPAAPLIVDEEKTESAEKLAPGSDSVSLQADEFLPVEQAVELKVEEPVIETESMNEQSDSSQSRTKQVGVVEDQGDEIARVNVNVDGEVENKERTVAPLTDKEDEGSNSLKGESKEDIVDSTVDSQNTSENLASIDNDQSESTGADDGPNEISAQGTVTPAESDGSTLGAGKKKKKKNNKKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0X7</accession>
    <name>B7G0X7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_13160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180940.1">
        <property type="nucleotide sequence ID" value="XM_002180904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0X7"/>
    <dbReference type="STRING" id="556484.B7G0X7"/>
    <dbReference type="PaxDb" id="2850-Phatr13160"/>
    <dbReference type="GeneID" id="7201623"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13160"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398689_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0X7"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="35474" checksum="28DB10642E379EEA" modified="2009-02-10" version="1" fragment="single">LAFCDDILVHVSRSFAAVIRQLPDRLLVDILVFYLVLRALDTIEDDTTAFASPEEKIDYLLNFHRTALADPDWNLQHVGQGDERRLLQQFPQCHRVYAKLAAPSRRVVADVTARMATGMAEFVRKDLGQGTTNTEQYNRYCHFVAGLVGEGLSRLFAASGLEAGSFAGELHLSDQMGLFLQKTNIIRDYLEDYVDQRAFWPQSVWKKYAATDDLGYFAQSIGTDDGRDRALGCLNELVTDALELVPDCLTYLARLQCQEIFRFCAIPQVMAIATLDKCYHNVNVFTGVVKIRKGLSCKLLLRTNTLSQVHETFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1G0</accession>
    <name>B7G1G0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181024.1">
        <property type="nucleotide sequence ID" value="XM_002180988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1G0"/>
    <dbReference type="PaxDb" id="2850-Phatr46502"/>
    <dbReference type="GeneID" id="7201586"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46502"/>
    <dbReference type="eggNOG" id="ENOG502SK8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356227_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1G0"/>
    <dbReference type="OMA" id="EIDAMCA"/>
    <dbReference type="OrthoDB" id="38381at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="723" mass="80345" checksum="11DD2D2F35A1E63E" modified="2009-02-10" version="1">MNTSRNETTIRSRFHRTALGTAVKLMAAAGCCVGALRAYQNNNNSITVGRSPTAAAVLSASPRRLQALGDNVPAYMQTYLQDLTDRQKLFDETPPEEVKYWFEYTGPLQKYFYRYSKTRGKADYFEGRDDSGVVSARFVEEAGANDEYKEFFQQRSPDQLPEGEADAYARLLENCIALGSTARPDTSAGTVWSQWFQENQDRCRILFAINTVGAGRGSTMLWETNPPRVHAEGPQPWISEQETAATHLLRNLQEIDAMCATGWIAARVQMLVCEPIPAKWTEWIDAQLVHCGGKPWPLDRAVDEDMDMEDRPSPVQIVVVASATTADSCHDLKSGLMEKRTQDLILAPPHLGKGGNDATQKTTNPDLVSSGDFDLHVAMKWTTLVSVRAVNSFLQASADMAAAASTTNPPSPTDNGPSSPFLVPSFVRVAYVSEENSKVAKWRMHGDFFHPAAWEICKDSFDMTWIPNSLSGGGGVNGLCDADSNTAVARKLSERQDCGQWWAYFTELQMPTSPEVYANEKTPPPVLGGSNFFWMVTERQRVELVQGMVCRHEGKSDCPAEPQAVIPLGDLESFLVNFTPNTALGKKHVKGRRPGYSQEDDREADRQRVLERKQLQDHEEIEKALFDYTIYPAALFHKDATLKAARARDAALTTHRNAEAVGPQTVKSSYYDVTITKPRGPVLGWCQAAARRGLCTLYADYFRTSNDERCMEACGLKRDFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1H5</accession>
    <name>B7G1H5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_20857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181030.1">
        <property type="nucleotide sequence ID" value="XM_002180994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1H5"/>
    <dbReference type="STRING" id="556484.B7G1H5"/>
    <dbReference type="PaxDb" id="2850-Phatr20857"/>
    <dbReference type="GeneID" id="7201595"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20857"/>
    <dbReference type="eggNOG" id="KOG0147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389575_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1H5"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="405"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="596"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="687" mass="75540" checksum="BD8ECB56E8B4412C" modified="2009-02-10" version="1">MPSPSPEKSRSGQTEEERLREVLRAKRKSRRESKGDNGDRDAQHDTDRTKSQSPSEKIKSTDRESARSPENLDRSQPANSNGHAEPQSNTQRSRSPDHRRERRPSNDRPSLDRSRGSRDERRRPRRHHHRDNSRHGSNPSRGPPGSRAHDPYYPPRRGGGLAANGAPMRGPPPPHHWRGPPSSGPPASRHRHRDLAALDRYDDFGRRRPPSRRSRSRSVSRSSSGTSSGYSSRSRSRSHSRSRSRDRRPRRQRGGSSRNRRRSHNSSTTSDVEHATQVDNTYTKDQRTVFVTQLVQRTQERDLKKFFTRKGCKVNEVILLRDKRTGKHKGCAYVEMKRMEDVSIAVGLSAEVPDFQRFPVLVKASEAEKNYLANASTATSTAAQMGVPIKSAPLLGPDGKMLEAQKVYIGSLDPSVSQEHLFALFSQFGQLEKVTLQMDSNTGLSKGFAFLTFHDPKEANLAIQTMANQALAGRPMKTGWASQGSSIPGVEVVTSDEFPADASTRAQRAYQVLAQLTMGVPVASVGQAPGTSSFAAAAAVPGGASRIPTVAEARASLAGAVAMAPATPAVLVPTPAVAPLGSPDAKIVGNADTPTKNVLIRNMFDKDKETDPGWEKDIKEEFEDECSKYGTITSVTVMHMEPGGKIYASFDSVIGAQKCASSLAGRWFDKRQLRVDFVADKDLPKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1W0</accession>
    <name>B7G1W0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_54612</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180922.1">
        <property type="nucleotide sequence ID" value="XM_002180886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1W0"/>
    <dbReference type="STRING" id="556484.B7G1W0"/>
    <dbReference type="PaxDb" id="2850-Phatr54612"/>
    <dbReference type="GeneID" id="7201744"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54612"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377033_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1W0"/>
    <dbReference type="OrthoDB" id="48196at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="736" mass="80852" checksum="BC0BA793A619F521" modified="2009-02-10" version="1">MAYTKTQTFGRTTNGSSTSAHCKPVKAKCVDNQSLVDALVAKRSTLGSNNYSRTLRKATESLAKQKEAVQSYAQAKALSGIGDHVANLLFPAAKLKSAESPASSVGSTKSTASRSRPRNTLPTADPVEKPSAREIAYQNAVQHATAWKSLSLTWRAVLLIDQRETQSDHVIAKCRMSGIPCEARSLPIGDMAWMAQGMDTAGKIKAELMLGTIVERKTVDDLKASLFGTRYNEQQLRLMHSGLPQVLFLIEGDLTKDLRGCSVETMHTATWEIRLHKDFQILQTAHLDETVQTLKRMHRRVLQRSFPRAFVTQALPTFSETDTSVNDKQAKRRSTDQAAPRKNRRRRLQSLMEMMFDVDPTPMPGTERFITYAELKAKVEYDRELGTRTIGSIHSAMLKQVQSFSDRKVQALCRTYSTANELFLAYESVNDVASKKALVTELPISDPSSHQLRKTGPKSAEELYTVYGMDEGISPPASISKDGTKPSLTAAWMPSPIQEEDDEDLWPNGDPNVKKYVESQMPFTSIDSQPMDIPLARCLISKSAASEQQPLSEVNIDKASRSEAQDEDLGDAFKGIGSSAPISSVCKRGVSKPLTAPTKAVNVDDYIDLLSSDNDEGGETDTAEPFAKCEKELDCLHFSGVVEQKAELAEFNIRSPAPVVVSQSRASFTAPSSLFSSDDDDASVFQRSPLRSKRKPFSAVGNSSCKKARFGCETEQTRTKRSAGNKAASPEVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1Z3</accession>
    <name>B7G1Z3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_37042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181287.1">
        <property type="nucleotide sequence ID" value="XM_002181251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1Z3"/>
    <dbReference type="PaxDb" id="2850-Phatr37042"/>
    <dbReference type="GeneID" id="7202076"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37042"/>
    <dbReference type="HOGENOM" id="CLU_864540_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1Z3"/>
    <dbReference type="OrthoDB" id="5959891at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36472" checksum="879F63D9F6FB200D" modified="2009-02-10" version="1">MCYDLLTIPPEIKQKIATFLCPHDAVQVGLTCVALRQSLSLSSLDPPLLLFARMDRVGDFEHGDNPVRAFRFPILNRRVHSLSLGLRWRDQGWGNRKGQVFVTAISASTVSQRRDAFEDGRIVFESDIAPHEQSALRINFVPIDSDIYYFWYKAGGGGGHSLHLSDGNLRTVIFDDEHQTIAQSYRNLTRIGVINPALLFENAPPAQTQTFFPCLLVRIFQLLRHQLEQKRTPDEELVTYLQEHEIAVNQRSLSALEGLVQADIEEREIRRHEGMDQVRNHAHIPTIFGLGRILLANPEFLVANAQNPDVLQAANQIDEGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7G290</accession>
    <name>B7G290_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_28433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181167.1">
        <property type="nucleotide sequence ID" value="XM_002181131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G290"/>
    <dbReference type="FunCoup" id="B7G290">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G290"/>
    <dbReference type="PaxDb" id="2850-Phatr28433"/>
    <dbReference type="GeneID" id="7202139"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28433"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="B7G290"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="167" mass="18985" checksum="A8BDA04E25043F3C" modified="2009-02-10" version="1">MSDYGTELLRRQLNDLAKNPIDLVSVGLVDDSNLYDWEILVMGPDGTLFEGGFFKARLVFPHDFPNMPPTMTFTSEMWHPNVYEDGKVCISILHPPGEDAFNSQETAEERWRPILGVEQILVSVISMLSDPNDESPANLDAAVMWRNDKPAFKKKVRQIVRKSQEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2A9</accession>
    <name>B7G2A9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181347.1">
        <property type="nucleotide sequence ID" value="XM_002181311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2A9"/>
    <dbReference type="STRING" id="556484.B7G2A9"/>
    <dbReference type="PaxDb" id="2850-Phatr47058"/>
    <dbReference type="GeneID" id="7202132"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47058"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412535_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2A9"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="72"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="606" mass="67168" checksum="F7C48AA117E8998C" modified="2009-02-10" version="1">MAIKSSSSNVTSKRKDGDSKFSSQPSKKSKGSGAKHSTVPPSTVGSKRAVKQERQSQRKHADVVNDAKRIWNQLRLKTNTSGQNRQYMDTLMPLITGKANEIALQHDAARVVQAAIQFGTVEERRLILQELCAKQNNFAELCKSQYAHFCALKAIKYCHSDPASVKLINKALKGHMPRLAVHAVGSRVVQSIFSTMTPKQSAVLKQEFYGPHFALFALDLPRNDAVPTLATNIAEAPEKKEATLIFVRNLINKGMEKTLYGFTYFQDLFAEYCEVADPREIRILAGTAADNSIHLLSGRAGTRVVASLISYGTAKDRKRIMKSLKGYTKSGLLHHDAYLAIIRLVQLTDDTVSIHKNIFNELLLPSDKSDEELSCPLLELALSDTGSKLLLMLLVADPETLKKFFDPYELSVLFENPTVIDDGQEVLTSKKEPEIRRKELIKYLREPLIEMCAKSANELIRSRPGALVLREVYHSYRPISVVEAIVGTCQAALNQDSSKGDEKDVQNYRLFEDRDGHLAVKNLLLADSAKESEAKLASAFFETFQDRLMEIAQSNRGAFVITALCKVLAVRKGAISKLNQAQLKKLADGKGATAGFKALVNEMDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2G9</accession>
    <name>B7G2G9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181207.1">
        <property type="nucleotide sequence ID" value="XM_002181171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2G9"/>
    <dbReference type="PaxDb" id="2850-Phatr37222"/>
    <dbReference type="GeneID" id="7202019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37222"/>
    <dbReference type="eggNOG" id="ENOG502SKKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G2G9"/>
    <dbReference type="OrthoDB" id="46155at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="467" mass="50822" checksum="1869ADA81AC23180" modified="2009-02-10" version="1">MSASSAAKGSDQSLSQLVKPPATAHALVPNTPLANCIAFVHASLFSPALSTWCQALDSGHLTTFPDLSSRQVRKYPPSSPVMIKGHLDQQRANLRSTKLFPVVPPTTTTPPADPEPDLDPPATHPIARTHHVFVAHQRVTGQIYTDQPGRFLTPSSAGHNNMLVLYDYDSNAIHVELMKNKSGPEILAAYQRAHSLFTQRGLRPQLQPERAIRTFKNHFIAGLCTTNPDFPLHLWDRLLPQALITLNLLRRSRINPKLSAHAQLHGAFDYNRTPLAPPGTRVLVHVKPSVREMWAPHAVEGWYLGPALNHYRCHRVWITETRAERVADTLSCFPTRIPMPAASSTDRALAAARDLVHALQNPSPASPFAPLDATQYQALTDLANLFATVTAPADDVLAPAPLPPVRPPAPATPLAQVRFAVPLVTAEHAPALPRHFRGCPPRPPITLAPATPAVAAAKSAPNRQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2I1</accession>
    <name>B7G2I1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine-triphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_37234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase highly specific for thiamine triphosphate (ThTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11744"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:58938"/>
            <dbReference type="EC" id="3.6.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ThTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.28" evidence="6"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181211.1">
        <property type="nucleotide sequence ID" value="XM_002181175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2I1"/>
    <dbReference type="STRING" id="556484.B7G2I1"/>
    <dbReference type="PaxDb" id="2850-Phatr37234"/>
    <dbReference type="GeneID" id="7201913"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37234"/>
    <dbReference type="eggNOG" id="ENOG502QZ0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_916713_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2I1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050333">
        <property type="term" value="F:thiamine triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042357">
        <property type="term" value="P:thiamine diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07758">
        <property type="entry name" value="ThTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039582">
        <property type="entry name" value="THTPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012177">
        <property type="entry name" value="ThTPase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586:SF1">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="14">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="32203" checksum="2B735026628E3818" modified="2009-02-10" version="1">MAFVFCQSNLSIALPISRIRFLTRSLRTSQLPRQHSNSDVFEVEQKFPLSLDSLPILEERLRILGFEQITTKELTDWYFDNVCSDLVQQDCWLRYREDENQGEWQLKKGVRGQYNGANTSTVYEEIEGAKALNAAVDLLAKVERKADVPLPFEFAGFAPFHIPKLLEEISLLQLHPFARILTKRASWVSTDQCNMMFWALTVDLDITDFGYAVGEVEAMIKDRRDVPRARAAINGLVKRLKPVGTHSTIAIGKLEYYLQSRQPELYQMCIERGIVKEPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2M0</accession>
    <name>B7G2M0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181231.1">
        <property type="nucleotide sequence ID" value="XM_002181195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2M0"/>
    <dbReference type="STRING" id="556484.B7G2M0"/>
    <dbReference type="PaxDb" id="2850-Phatr13779"/>
    <dbReference type="GeneID" id="7201932"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13779"/>
    <dbReference type="eggNOG" id="KOG0744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028208_1_1_1"/>
    <dbReference type="InParanoid" id="B7G2M0"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="33142" checksum="40BCAB27242D6293" modified="2009-02-10" version="1" fragment="single">LPHASLHGVYESLIFETDIGQDLLSFASSASLFADQHVQSHVVHWNRLLLLHGPPGTGKTSLGRSLAHKLAIRTSARFPRANLLEIHSHSLFSKWFSTSGKLIHRVFELIRDMVQDDPSCLVCVLIDEIESLAASRSALTSTGEPSDALRAVNSLLTSLDRLRSLPNVLVIATTNLTASVDAAFLDRADLKIYIGLPCLQARYEILRSCLDELARVGILTISNPSSDALLAFRDIARSDESQPSTVLVSLAGMAEGLSGRSLRRLALQAHALFVRRPQASLTLFLSALQRTIEREIGSLPSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2S9</accession>
    <name>B7G2S9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDK2</name>
        <name evidence="11" type="ORF">PHATRDRAFT_42104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181437.1">
        <property type="nucleotide sequence ID" value="XM_002181401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2S9"/>
    <dbReference type="FunCoup" id="B7G2S9">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2S9"/>
    <dbReference type="PaxDb" id="2850-Phatr42104"/>
    <dbReference type="GeneID" id="7201964"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42104"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="InParanoid" id="B7G2S9"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="148" mass="16448" checksum="CBCFC1608B6DE19A" modified="2009-02-10" version="1">MERTYIMIKPDGVQRGLIGEIIKRFEAKGFKLVAMKLTAPGKEHLEKHYEDLKDKKFFPGLIAYMTSGPVCAMVWEGKGAVKEGRKMLGATMPSESAMGTIRGDFCIEVGRNICHGSDAVESANAEIALWFPEGVCDWESASQPWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3H2</accession>
    <name>B7G3H2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_47468</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181789.1">
        <property type="nucleotide sequence ID" value="XM_002181753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3H2"/>
    <dbReference type="STRING" id="556484.B7G3H2"/>
    <dbReference type="PaxDb" id="2850-Phatr47468"/>
    <dbReference type="GeneID" id="7202584"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47468"/>
    <dbReference type="eggNOG" id="KOG2811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388568_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3H2"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:tRNA methylation"/>
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        <property type="entry name" value="Methyltransferase_TRM13"/>
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        <property type="entry name" value="Trm13"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
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        <property type="entry name" value="ZF_CHHC_U11_48K"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="73"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="538" mass="58822" checksum="32B47E8878D5BB10" modified="2009-02-10" version="1">MGEPTDLPLVSQIPPLPKEWARCHAYIDNKRRYCRQHPIEFEDAPATDHKADTGRPRYCGNHQHLLANRKRKRIPCPADASHSVYEDCVAKHLSVCPMLKKQRGQEKQSFYRKNINTGGYGPLGEIEEIATSQIRSKLDHEMSQFAESVLRLHQKLFAGDNIQDPSVLSAEDIHQAIPTEDLSSAEFDAGLAQAVSDYRIKSGGQKHLHQQASLVGHLRRIGALPSLSKGSRHTDKIKSVGKHLILEVGAGRGMTGLVAAGVSVVHGDPTDLIMIERAGSRGKADTVLRNAPICVKQTTSDVPPYLDLKGPLSWSRVQCDLSHLSLSSILLNADLEENDRVTVLAKHLCGAGTDLALKALEPVKTSISSCILATCCHGVCNWQDYVGRKFLVDAFQKNCPSQPFGAFEFELLRRWSTGTVKAGAAENRLGENRIEIADSSLQEHGLGTVLVENASANISRIVEASRLRCGAQGLGRACQRLIDYGRQEYLRGVLFPSAKHANGSVETTNIDMLHYVAPGVTPQNAALVAFSEKTGHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3P2</accession>
    <name>B7G3P2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002181432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3P2"/>
    <dbReference type="STRING" id="556484.B7G3P2"/>
    <dbReference type="PaxDb" id="2850-Phatr47242"/>
    <dbReference type="GeneID" id="7202296"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47242"/>
    <dbReference type="eggNOG" id="ENOG502QQN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034985_1_0_1"/>
    <dbReference type="InParanoid" id="B7G3P2"/>
    <dbReference type="OMA" id="TACMCCT"/>
    <dbReference type="OrthoDB" id="62987at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="527" mass="58785" checksum="D28735D1F065A723" modified="2009-02-10" version="1">MSTSGQQESEDPGLGTRERRHQQRMKSAALSSDHTRSLGTDEELQSLTAKRSLEKDAFSKTTGGDFGICLFWGLTLAGIASSMLTTTFGIFHVDVFLRSYQLPLSTYSYGNAVYAIINTANDLAGAWLVDHVATRRNRTDLVGMAGCIFAVCFLTPFFRWRAPSQSWDGVHFVTTLSLYDTMFAFMAILMGSIITDNHKMSEKSRVRFMASGKLINLFTSFVVARVGLSTFDVQDLTHFRIFVVFLAMLVSIMFIVAQRMIYVKSRTVTASGQDALKVSASATAASSSKGKLHWRQVALGMEMLLEAQMTFMSSFTKTFVDRLLFDSGYSRASCDWLLSTLRPIKAIAGILIYVPIRKFGYTKIYSTLFVFNFLLSATVLTVADSSSTRWILTFLVLYSVITGAVQSSGFHLAMSDMVTEMKRNHAKERRFEEPSLAGLFMGANALFCKPMESLLPIVAGTVLQNKGDSQQNLFYLLVIPVLLFSVAQFLFWSRYELTPDRMKGFRHELDSLHSEQGRACTSIAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3S7</accession>
    <name>B7G3S7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181663.1">
        <property type="nucleotide sequence ID" value="XM_002181627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3S7"/>
    <dbReference type="STRING" id="556484.B7G3S7"/>
    <dbReference type="PaxDb" id="2850-Phatr47265"/>
    <dbReference type="GeneID" id="7202355"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47265"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473699_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3S7"/>
    <dbReference type="OrthoDB" id="47600at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="709" mass="80077" checksum="8FEF89A20B55D85B" modified="2009-02-10" version="1">MRTTKAFFHLSHYHYHHRIIQATRFQSAATHFIPSKDLKRRHFKSYGDLISKTNELIDLVKNPVRAIAEAGSPITVHDCFHTLEAWMEYAMDEKTIEAPLQAKRLLDTLERNTILRFDSVFVPKASFYEVVMQGFAVCNGGRNAAEHCQHILQNMIFQCRRYSQESRSERRIPPVEPTIKAFNISINCWAKSGADDSGKHSEAVLELMGTWKRECEESSDVSLYVGCLPNGATFASIMDAWAKGDSGLAPHRTLSILKSLIASVRAGDLHVSVLQPRLFNIALHAWARSGLGREAARKCEDILQLMSTLEREYGVNASPNTTTYAVLIDAWANCEKEEKDGEAAQRAESILFKMIQLYRNGHGVKPNKVCFTSCVNAWSWSGRIHDAPEKAERIWRTLDELHKESGGHPDFCPDTEIGNAVLAAWSRAVRKPDSIGRALAFLEKLKLNFTTDLVSYNTVLDALGKRGLSSKSLDLLKWLEVESKDRDLSLQPDVRTYNSVLASIAKDEERRCPKKAEELLQTMQAKSSEGRHTIKPDRVSYTIVIDAWSRSDDPRRVEKAKALFVQLINEFQKGDQNMQPDAYVFTVLMKTCLGVTGSDERKRFALRLLVDTMKLMKSAGFGPPNHVTYATYTKAVERLCDNDELKRKLLIEAFKDCAAGGHVSKKVVFAMRPLGIASIQMKTSWSRNVPNRFKPDTNKWMDWSALTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G412</accession>
    <name>B7G412_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_52248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181835.1">
        <property type="nucleotide sequence ID" value="XM_002181799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G412"/>
    <dbReference type="STRING" id="556484.B7G412"/>
    <dbReference type="PaxDb" id="2850-Phatr52248"/>
    <dbReference type="GeneID" id="7202778"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52248"/>
    <dbReference type="eggNOG" id="KOG1958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251197_0_0_1"/>
    <dbReference type="InParanoid" id="B7G412"/>
    <dbReference type="OrthoDB" id="39075at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="173" mass="20471" checksum="6C4FDBE8F643E756" modified="2009-02-10" version="1" fragment="single">MRQLVRTLSFDNPDGGVWKQGWNVTARDDFTNAQPLQVFVVPHSHCDPGWIKTFDDYFQSQTRQILTTVVQALQRDQRRKFIWAEISYFEWWYREQKDDTRKVVQTLLDNKQLQFVTGGWVQPDEANSELYAMEIQLQEGHDWIRQTFGDAHVPKHGWSIDPFGYSPTMAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5M2</accession>
    <name>B7G5M2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182272.1">
        <property type="nucleotide sequence ID" value="XM_002182236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5M2"/>
    <dbReference type="FunCoup" id="B7G5M2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5M2"/>
    <dbReference type="PaxDb" id="2850-Phatr47998"/>
    <dbReference type="GeneID" id="7202998"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47998"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358439_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5M2"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="782" mass="84929" checksum="EDCB4BEFBFCB8B41" modified="2009-02-10" version="1">MGNSASSLPYAIGKQTAIVNDGWALHEGTQKSDGSDVSVFVAKKAVLNKTAIDRARDPSRTQLEPALHHFSYCKKLRHPHILQVLATLDTDHPNDANNATAVSSTAASQATKETGDLIIVTERCVPLDVWLQQENPPPEQLAWGLEVVVCALHFLHASANLAHGNISPASFFVTRAGDVKLWNFVLVTPTHQASGGLSNHFQTYEDLLTPQPYRSPERQQRNWAALAAEGTHAMDSFGLALLIAHFYGGTVPPPLQKAVQRLQTPNVKMRPRLQPLLKCPLFDTPYQKLQLQLEEFMVKPVEEKIAFWQNLTPQLQAALIPENLAVYKLMRIMKSTIDTICQSDSMRSQDMYRREYLLCESHPILVPSHHAVSSILKPLFFVGEHYLDNDFGKELTSTVSILFTVNDRGIRGALLQKASLFSKHLDKNTLNQAVFEPVCSGFSDSSSALRELTLKATLGMVPCLTPPSLEKLSRYLVRLQSDPEASIRTNTVIFLRKLAPHLTDTTRHKMLLPAYVRALKDPFTPCRLAALQSVLTSKEFFEPNILAGKVLPAVTPSLLDGAADVRKEAFTVVDDLLFALRQESERMNSQPDASAKTAVTAPGVPPSVPQTSTTPVPSAPSSGGYLTGLSSWMTSSAKPTEPVPSTARAGPPRSAPAPAISAPAAGAGYTPAAPLAMAHLTLDDDANDDDGGWGDDDLDVSEPPRAQRPTGVTTTKSSLFAPAPAEDDFFGSFDAKPVKQASLRVSSAGKLSIPAKKTKPVTKAAITKLAADDNMDDGWDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5N4</accession>
    <name>B7G5N4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_48010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182279.1">
        <property type="nucleotide sequence ID" value="XM_002182243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5N4"/>
    <dbReference type="FunCoup" id="B7G5N4">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5N4"/>
    <dbReference type="PaxDb" id="2850-Phatr48010"/>
    <dbReference type="GeneID" id="7203005"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48010"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669912_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5N4"/>
    <dbReference type="OMA" id="GFMMHIA"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="411" mass="42937" checksum="013BA1B3E7D2C3C1" modified="2009-02-10" version="1">MGTSQSRDGSAVHGGTPCASLPFRRVPLSTLLLPSTLSAVATTACEDPPPPPPPLPVDSGSSTTGKSSTQSPSSSSAPPPPPASGEEAKSDDIASAAQAASAYVNPGPFEQAIGEGKRFFMLDTFDGFRCDINKQASPFMLVLHNFWLGTSMLPDGRTSTYSFVTQVADEAGFMMARWDPGQASVNGRVHRALLGGLAMGKLQIGVSAEGQNDTLLGEVDFGGHSWMGNLRYGSMGGGVVLGCNYMQALTPALHMGGDGMYVGANGSFQTNYALKYTMPALTGEEDLPTTTPAKPATGMETAGSSTLCAQFKPGQGMASLDYKRVVTPNRVTLASSLEFSPLSLESQLLVAAEFKLSRSTLNLCVDGSGHLQSVLEAKLGMGQGSPTINFSADMDHAKQQMRFGYGIKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5R0</accession>
    <name>B7G5R0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182452.1">
        <property type="nucleotide sequence ID" value="XM_002182416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5R0"/>
    <dbReference type="STRING" id="556484.B7G5R0"/>
    <dbReference type="PaxDb" id="2850-Phatr48032"/>
    <dbReference type="GeneID" id="7203023"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48032"/>
    <dbReference type="eggNOG" id="ENOG502QS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_2_1_1"/>
    <dbReference type="InParanoid" id="B7G5R0"/>
    <dbReference type="OMA" id="SVIDGFW"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="264" mass="29080" checksum="CDBD237E554277DD" modified="2009-02-10" version="1">MKFPVLFLNHGGGPLPLMGRQLHLAAHMKQVVKQHLPLEKPKSIVVLSAHWESDPIKISSAEAPKMYYDYSGFPPETYKYQYPAPGSPQLATKIHSLFEDNGIPSELDPARGFDHGVFVPLMLMYPDADIPVVCVSLHSSLSADTNMEVGAALQPLRDEGVLILGSGYTFHNMHAFFNPSPETHEASKLFNEWLKTTITGPGNVATKLSRWEQAPGARVAHPREEHLMPLLIVMAAGGIGTTPKVIFDLPDDHENHAVSGYLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V0</accession>
    <name>B7G5V0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_38429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182469.1">
        <property type="nucleotide sequence ID" value="XM_002182433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V0"/>
    <dbReference type="PaxDb" id="2850-Phatr38429"/>
    <dbReference type="GeneID" id="7203417"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38429"/>
    <dbReference type="HOGENOM" id="CLU_1573695_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855806" evidence="3">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="170" mass="18749" checksum="CCDDB4971D6144CB" modified="2009-02-10" version="1">MSMLSLLHASAIWSVDGRVPQNLRVRKPALEGIPMVIDTKSLNDSVPAGTDDHNDCTRRALAQLGKINADLEDTYGGFQLKYWIIFGASLLFLVCCCTGCVFWRCRRRRGKETNAVKQNSGKSDGDGEKSSTMVTRNNSGHTSTTQDTPDTDRPNAWANAHSNHSMSVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5X0</accession>
    <name>B7G5X0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_38448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182477.1">
        <property type="nucleotide sequence ID" value="XM_002182441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5X0"/>
    <dbReference type="PaxDb" id="2850-Phatr38448"/>
    <dbReference type="GeneID" id="7203429"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38448"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1565922_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5X0"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="153" mass="16515" checksum="A1FF15C76FB029D8" modified="2009-02-10" version="1">MAFETVTKLEPVDASVIEAGKKLATGIFLTKDIVNAPHNVLNSLSLAETAKRIAEQNGGRIICEILDKEACDARCMGGFLGVARGSETPPQFIHLTYTPPSGKISKKVGVIGKGLLFDTGGYNIKTAMMELMKSALKHRVGRFSKVLYFLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G624</accession>
    <name>B7G624_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182501.1">
        <property type="nucleotide sequence ID" value="XM_002182465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G624"/>
    <dbReference type="PaxDb" id="2850-Phatr48124"/>
    <dbReference type="GeneID" id="7203281"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48124"/>
    <dbReference type="HOGENOM" id="CLU_390031_0_0_1"/>
    <dbReference type="InParanoid" id="B7G624"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="708" mass="80116" checksum="77CB97388936BCA6" modified="2009-02-10" version="1">MGGPNQKCEETPVSQQEKLTRWREERQRKQKSTKNQSSFILTKSLNRSRISLGGNSLSSLPAQQTTEVQERIPNRVIRGAKSIDDARSRLFRQTKNNFRSPLVSVANVRCPAHPGSSRETKLCLNKQLSLLEMSNCKQAPLDATKSTSTSPFCSWVALDTPQSTSPLSWNEDYVELAEPPIDSTPIPQTSKVCRQSMLDYQAAPQSKLSRNRASGEQLRDDLPLLESALQEFQQGLDSFDWRNETTEESAQGMDPICRSYSGEDPQFLLPIPSSREANSTKQHNKASTSADIAQRHLSQDSELRTNTSVEKPSIRQRSQAPFAFPSLGHPSLLRQISNPEDNGLPIPAPLTTPRNSSFLTLDLETPEEDWPRRQDAKQLLLPIPSLREHLPPFKDKAPKSDFPSREEFIDYTKGENSGTEKNKTAFSSQKESSWERSPSNIQPIKASLPKTANSNLAEPRLQEMQVWDLKDEDDSFDWRHDVVSPDFHPSQPSRRRASSVLLPIPSLRNDLDGTPDQDLQANRKEEATNTVDNSTDAEIEHKCSGQLKAPDKLADEKPKKVWSPKNCSCKTNVHSETSVKFKDFEQHLPLETVPEEAMDQIPTLKEQLVLSLNEIKRLQDQVKVATAFENRVTPFRDVFEDLRKMRADNTKLRRDKEQIEQMVEGLQQQMMTAVQMAVQKTKGLQIQLEASQSELHAARELIRQLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G643</accession>
    <name>B7G643_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_38526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182511.1">
        <property type="nucleotide sequence ID" value="XM_002182475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G643"/>
    <dbReference type="PaxDb" id="2850-Phatr38526"/>
    <dbReference type="GeneID" id="7203290"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38526"/>
    <dbReference type="eggNOG" id="ENOG502SBD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932010_0_0_1"/>
    <dbReference type="InParanoid" id="B7G643"/>
    <dbReference type="OMA" id="SARYMDI"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855862" description="gamma-glutamylcyclotransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="36138" checksum="B875DDA304C550A4" modified="2009-02-10" version="1">MKLKVLSVNWIFCCCLVAALQKSTDPPTRPQIVQDAFNNNTPLYYFGLGSNMLRSKLENRSSQGKIEILSMEPAVVPSHRLAFNLRGFPPLEPGMGSLEPVNATSRALMAYNKPECHGALVQLVPEMYERVMKSEGVGMNQSGYEEIVVTAVPYDPRKPPVQAIALRAKPHVRLRRDPSPSARYMDILRQGAAELQLKPCYQEFLAQHPVQILPTWLRRLSIYNLIFTFSLSNKLKWRGVSKMQSWLLFRVYVPSNASWICRHGCSVCTAGILLPGAILGSAIKMVVSKWGGDFPPFLKRMMDLLDDPLVAAPKANAETVEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6E8</accession>
    <name>B7G6E8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182714.1">
        <property type="nucleotide sequence ID" value="XM_002182678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6E8"/>
    <dbReference type="PaxDb" id="2850-Phatr38634"/>
    <dbReference type="GeneID" id="7203535"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38634"/>
    <dbReference type="HOGENOM" id="CLU_1067354_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6E8"/>
    <dbReference type="OrthoDB" id="44721at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="261" mass="29423" checksum="9BD592EB78A1EF80" modified="2009-02-10" version="1">MTMTTRRRLLVLGSSRPRSTSPLGLILLGAALATSQSFQQVVQWLKDHAESLLVPLYIAIVTVYLTYVAFREHLDPVLRVLFEKKAQGLESMSSRVAAPSTSELDPAFLRKADLDDPQPVDLTGVYKLISNDNFDGFLEVQGIPWALRRAANAARPVHRITHRGSHLTIKIEGIIESQTTYIINGPPVETNVRGRIFRDQVTYLENDRGIVVRKTAVTENYDVTVQRELSTDAQHIVMTSTAMFRDERVPVQCIQHFDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6S9</accession>
    <name>B7G6S9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_6062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182909.1">
        <property type="nucleotide sequence ID" value="XM_002182873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6S9"/>
    <dbReference type="STRING" id="556484.B7G6S9"/>
    <dbReference type="PaxDb" id="2850-Phatr6062"/>
    <dbReference type="GeneID" id="7203558"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6062"/>
    <dbReference type="eggNOG" id="ENOG502QVPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740737_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6S9"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21560" checksum="B54321D867302298" modified="2009-02-10" version="1" fragment="single">SIAIPYEGAPALLDGSLVGDVGFDPCFLSTKADTVAAPYFNGIFNNEVSIDGLTWYREAELMHGRICMIAVVGFIAPGFGTFEGNAWTGADAFSNTNPLEALGAAPSASIFQIFAFMAALEFRRINIIFQQGNNYQPGDSQRWGQGDGRWNPLGLNYSPEEYEEKQLQEVKHARLAMVGLLGLLFQANASGVNVIDQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6T2</accession>
    <name>B7G6T2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182911.1">
        <property type="nucleotide sequence ID" value="XM_002182875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6T2"/>
    <dbReference type="STRING" id="556484.B7G6T2"/>
    <dbReference type="PaxDb" id="2850-Phatr48341"/>
    <dbReference type="GeneID" id="7203802"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48341"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_0_1_1"/>
    <dbReference type="InParanoid" id="B7G6T2"/>
    <dbReference type="OMA" id="WFAWCNS"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="566" mass="64228" checksum="970EBA47795188D8" modified="2009-02-10" version="1">MANVTLRRTATSRSDSTVQTEGTTATTRSSGASTRRRKAQSRPKGLTLSSSLLLLLLIFFVYALLAVFMPRHQPSSASKELAKMLRTEGIRSSAKNYFPPAFPTMHRDVQVTLSRDALDMCTQALWHTVETTTVVLPDHETFVHTGDIDDLWLRDSAAQIHPLLVPFNGTALIQQDPRLDRIVSGLIKRSAMYIRHDPYANAFRIDDSYVFSEEQKRLGRHDLISTWNYELDSACYFMRLLYFYWKQAPSTEVLLQPQVQEAVQIMVTLWKAEQKHELDEFPVGNLLDCQNCNKPYRYPGLPRDGKGSLTNASAGLTWTGFRPSDDECQYGYLIPANMFAVVALRYMEEMAKDLWGNQLLAESCGELAGEIQLGIETHGIVEHPKFGKIYAYEVDGLRNSNLMDDANVPNLLSIPYLGYEWYDPDVYANTRRFIFSPSNPTYKKGNNPLTGEIEGFGSVHMEARIRENIWPMSLAMQGLTTDDVDEKVRLVETLVQASAGTHWMHESIDVHNPNRFTRAWFCWSDSLFAELVLSLTDACPDSSHKYRVHEWRDPETIDGGPFAAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6T9</accession>
    <name>B7G6T9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182788.1">
        <property type="nucleotide sequence ID" value="XM_002182752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6T9"/>
    <dbReference type="PaxDb" id="2850-Phatr48347"/>
    <dbReference type="GeneID" id="7203807"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48347"/>
    <dbReference type="eggNOG" id="ENOG502S453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492181_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6T9"/>
    <dbReference type="OrthoDB" id="47105at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="550" mass="61567" checksum="C64F45EEA2E3DE54" modified="2009-02-10" version="1">MSPNGNGLLTLPLELQVRLLTYLRAYDLAAVQQVCRCFRQPELVHGIVAHAAEHVYPPSLTRGFDQQPTQSDPYRPLPATKDPPVAKSNAETDQRNKPCYTFEHLRNMELLVVARVLNSPEPSTGYIVSKSWCKSALKWLEAQQEEQQAAKTNKKISKKKQRLRQRRLSDISPPWPNVNSDLLCEHSCLSRCSNGKSARARRRYVNKQAWKILKKLYPDSTSLDATTGECLQCFAESEMNKKNQRDEEECRKLERKRPLSNPSLRRLYTRRTGVPLHAIRRAEVTVFSSTDSAVATPCEKIALATPCPLRDGKYFVLPRAWCHQWRRYMKTGEGGPCPAPDAAGLLCDAHRLPLLPPHLEAYLEGQATELFASNETEIMPAMVLATPPAAAVNGPMILPGQGPDQATLQAMREAGLGEHQIGQQLSALRLLETQQRQYIQQQPHVMLDNIDAPVARNPPNKNELLDRENHSVVELLAEEEYQALESCYKGVSSFALRLDVVHGVANLSTPPCRACDASGRASRALVVKNRARSWVKKSGDQPRAPASLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6X8</accession>
    <name>B7G6X8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182807.1">
        <property type="nucleotide sequence ID" value="XM_002182771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6X8"/>
    <dbReference type="PaxDb" id="2850-Phatr48380"/>
    <dbReference type="GeneID" id="7203644"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48380"/>
    <dbReference type="eggNOG" id="ENOG502SX19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G6X8"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="254" mass="27949" checksum="DE54B77E12420739" modified="2009-02-10" version="1">MVSRSRGGNLVPIRVDAFYEDDKKMIHIRLVDTLLLDPQLLPLPHSSLEENTQHLAYTMLSDAEVLGMGRTVRHFTGRLDLWSHPLQQLIADQIRPQLQQALSGKRVLLDTIRERNTKKVKLEGNSTSSGKDPGSGLPNSNSQVAPPESAKEALKSSEGENTQTVTAATEKVDFASKTKDEGTEQVHSFSRLEQEKSSSSSLIPIRLRLSVHGVRIHDDFLLGPSIEERKSAGFCSGFGTRPEAIGRSSSSHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G713</accession>
    <name>B7G713_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_22418</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182954.1">
        <property type="nucleotide sequence ID" value="XM_002182918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G713"/>
    <dbReference type="SMR" id="B7G713"/>
    <dbReference type="STRING" id="556484.B7G713"/>
    <dbReference type="PaxDb" id="2850-Phatr22418"/>
    <dbReference type="GeneID" id="7203662"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22418"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="InParanoid" id="B7G713"/>
    <dbReference type="OMA" id="KFRWNVF"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="33"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC45690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="566" mass="62319" checksum="C4C145DDD2A6928B" modified="2009-02-10" version="1">MSDQTSSRDAASNQLDAYASQRYVVSPAIELLKASNGAPVDSLTASMTAGPRGPIVLQDFTLLDHMARFDRERIPERVVHAKGAGAFGVFQVTSPEPIRSVCKAQVFQSMEPTPVAVRFSTVGGETGSADTARDPRGFAVKFYTTEGNWDLVGNNTPIFFIRDPMLFPSFIHTQKRNPATHLADPDAFWDFIGLRPETTHQVTFLFSDRGTPDGYRHMNGYGSHTFKNVNSNGEAVYVKYHWKTDQGVANLDAEHAARLAASDPDYATRDLYNAIATGNYPSWTLYVQIMTYAEAAAVDINPFDLTKVWPHSRFPLHEVGRMTLNRNPKDYFAEVEQLAFAPSHLVPGIEPSPDKMLQARLFSYPDTHRHRLGTNYQAIPVNAPRNISAAQQHNYQRDGPMQVTENGAGAPNYFPNSFGGVQPPPATAHGPELAWHADTVSGQVVRIDTGDEDNVSQCRDFYRNVLDQAARARLTDNLAAHLCRAQPFLRARAIHNFTQVDSTFGAQLKAAVAQKVMHTPPPSQSRRRPAKLNPPRIVPPPTASRGLCPAGYGNQGSPAHGYASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G741</accession>
    <name>B7G741_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182839.1">
        <property type="nucleotide sequence ID" value="XM_002182803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G741"/>
    <dbReference type="PaxDb" id="2850-Phatr38884"/>
    <dbReference type="GeneID" id="7203612"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38884"/>
    <dbReference type="eggNOG" id="ENOG502RY6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G741"/>
    <dbReference type="OrthoDB" id="2580091at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd08357">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852982" description="VOC domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21501" checksum="C78C23F728939DFB" modified="2009-02-10" version="1">MVMRSRWLASTLMTLSPLSCTNAAAPFVSRLLIAAQQSSKPAADPAPGSPFHYAFPVHNLEAAKDFYENVLGCVEGRSSEKWQDYSLHGHQIVAHWAGNDYRCQDYYNPVDGDEVPVPHVGLALTVEQFHELAERVRSKGVNFIIEPHLRFKGMPGEQYTMFFKDPSGNNLEFKAMTHPENLFAKYNVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7R2</accession>
    <name>B7G7R2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183191.1">
        <property type="nucleotide sequence ID" value="XM_002183155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7R2"/>
    <dbReference type="PaxDb" id="2850-Phatr48579"/>
    <dbReference type="GeneID" id="7194739"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48579"/>
    <dbReference type="eggNOG" id="ENOG502SCY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265434_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7R2"/>
    <dbReference type="OrthoDB" id="46933at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="27540" checksum="9756CFEC81135EED" modified="2009-02-10" version="1" fragment="single">MCGGELDSSRTDFCYDPTGGPTPVTPTASPATQLTDTPVAQPTVAQPTAGPPVTFVGNNGGPSSVFPLMACQGDCDVDDDCEGMLECFQRDGGEAVPGCGGGELDSSRTDYCYDPTGGPTPVTPTASPATQLTDTPVIQPTVAQPTAGPPVTFVGNNGGPSSVFPLMACQGDCDVDDDCEGMLECFQRDGGEAVPGCGGGELDSSRTDYCFDPAGGPTPVTPTASPVADLSPSPATNLSPSPAVDLSPSPVADLSPTPVADLSPTPVADPSPSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7S4</accession>
    <name>B7G7S4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Acetyl-coa carboxylase</fullName>
            <ecNumber evidence="30">6.3.4.14</ecNumber>
            <ecNumber evidence="30">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ACC1</name>
        <name evidence="30" type="ORF">PHATRDRAFT_54926</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="31">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="30"/>
    <dbReference type="EC" id="6.4.1.2" evidence="30"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183067.1">
        <property type="nucleotide sequence ID" value="XM_002183031.1"/>
    </dbReference>
    <dbReference type="SMR" id="B7G7S4"/>
    <dbReference type="FunCoup" id="B7G7S4">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7S4"/>
    <dbReference type="PaxDb" id="2850-Phatr54926"/>
    <dbReference type="GeneID" id="7194806"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54926"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_1_1"/>
    <dbReference type="InParanoid" id="B7G7S4"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000043">
        <property type="entry name" value="acetyl-CoA carboxylase 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0092">Biotin</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9 30" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853067" evidence="24">
        <location>
            <begin position="25"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="27">
        <location>
            <begin position="89"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="256"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="25">
        <location>
            <begin position="722"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="28">
        <location>
            <begin position="1378"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="29">
        <location>
            <begin position="1716"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="968"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EEC45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2092" mass="229514" checksum="F5314FEA6E4624D1" modified="2009-02-10" version="1">MLSRGYATAALALLVAAAAHHASAFTSNSPAAFLSNGLAKVQRQNVVGVSRENDRGLDTALWSTLDEPITLGGVKALEDYVKERGGNLPIRKVLIANNGMAATKSILSMRQWAYMELGDERAIQFVAMATPEDLKANAEFIRLADSFVEVPGGSSANNYGNVDVICKLAQEQGVDAVWPGWGHASEKPALPDGLAKIGVKFIGPPAPVMSVLGDKIAANILAQTANVPSIPWSGSFGGTDDGPLQADLTDEGTIPDDIFEKATCRNVEEAIQAAEKIGYEEGLMIKASEGGGGKGIRFVDNEEDLRNAFIQVQSEVIGSPIFIMQLCKNARHLEVQIVGDEHGNAVALNGRDCSTQRRFQKIFEEGPPTIAKVDTFDEMQKAAQRLTQTIGYVGAGTVEYLYNAATDKYFFLELNPRLQVEHPVTEGITGVNMPATQLQVAMGIPLYNIPQIRHLYGKEDIYGTDKIDFMVEKYKPIDTHVIAARITAENPDEGFKPTSGSIERIKFQSTSNVWGYFSVGANGGIHEFADSQFGHLFAKGATREQARKSLILALKEIEVRGEIRTTVEYLAQLLETKEFIENTIDTSWLDGIIKSKSVQIEMPEDLTVISAAVFKAFKHVEEAVEDVKESFRKGQVSVGGVPAMNSFDIEIAYKDTKYTFHVERTAEDLYLLSCAGNTIEVRLTLTAESAILATFGGETHRIDGMDEPLGLRLVLDGNTILMPTIFDPSELRTDVTGKVVRFLQDNGGSVEAGQPFVEVEAMKMIMPLKATESGKITHNLSPGSVISAGDLLASLDLKDPSKVKKIVTFEGEFKIPSVALETAATDMISHILAGYQGDAEFAANAAFEDIEDVETAATLVTDTLNEFLRVEKIFNGRLLDDVVRDLTKANSENLDHVIAEIQAHLNVRLRSQLILAMLRQVETFSDRFGVAEISGDLLAALEELQTLKDKMYGEITLAADTIIRQSKIPSFESRVEELRAQLSDTETDLVKLSKSPTLSAGVDLLTYLFTDSDGLVRSAAVEVYVRRVYRAHRMLDLSVEDKSGRLTCSFTFQFSDVPENEAPTRQGLLSVVASMDSFKSDFANILEDMSEAIGEKPATSDGRPLTALHIAMADGEMGEFSVVEGVLASEKPKLIAMGVRTVNFVVPNKKKEPSYFTFPQADNYKEDRLRRNMRPTFHHLLELARLTSNFDAERIPAIGKNAQVYIGTEKSERPVRGGPPQVVFVRAISHSSGLVTDVGALRALQQGLDELERAQSNSKVNLQSSSRIFLHSLHELEGTTPQEVSARFKAVMSSLKSKLATRLLKLRVDEIEVKLRIASKSEDGSPIVQNVRLVGSSMEGEWLGATTYIEKPDPVTGVTTEFCVLDESGEANMCFLDPYGTSNIIQTKRAIARRVGSTYAYDFLGLLEVALIGEWEQHINSLELDTGVTIPTDLFESQELIEDEDGNLVLGSRVVGTNKIGMVTWVVKMKTPEYPEGREVVVIANDVTVQSGSFGVEEDELYYKASVYARERKLPRVYIACNAGARIGLVDELKEKINIKFNDPTNPNKGFEYLYLTDEDYKALPEGALIASKVNEGWALSDIIGTKHGIGVENLQGSGKIAGETSRSYDEIFTLSYVTGRSVGIGAYLVRLGQRVIQMKQGPIILTGFSALNKLLGRDVYTSNNQLGGPQVMQPNGVSHDIVDDDQEGVTSIMKWLSFVPKTVGALPACRESADPVDRPVAWRPTPTPYDPRLMLSGTADVPGFFDKGSWKEYLSGWGKSVVIGRGRLGGIPMGAIAVETRLVDKVIPADPADPNSREAILPQAGQVLFPDSSYKTAQALRDFNKEGLPVMIFANWRGFSGGSRDMAGEVLKFGAMIVDALREYENPVYIYLPPHGELRGGSWVVVDPTINQEKMEMYADPDSRGGILEPAGITEIKFRTPDQLKVMHRQDPQLKLLDAELEMCEMEDDKAAIKEQIIAREEQLKPVYLQAATEFADLHDKTGRMKAKGVIREAVPWEQSREFFFWRAKRRMLEDAAAGQMRQGDASLTKDSATDLLKDVFSGDWNDDKAVADFFESNASDVADKVKAVKAAGVQAKIDALKKELDGLEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7T6</accession>
    <name>B7G7T6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183202.1">
        <property type="nucleotide sequence ID" value="XM_002183166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7T6"/>
    <dbReference type="STRING" id="556484.B7G7T6"/>
    <dbReference type="PaxDb" id="2850-Phatr39095"/>
    <dbReference type="GeneID" id="7194812"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39095"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_901464_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7T6"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37430" checksum="C0878CAEBEBFD9D0" modified="2009-02-10" version="1">MSTAFAGALQAEWNERKPSHRITPKRSGHVAFPSPHSSDVYIFGGYAEESPSNRYVTNDLWRWNSEQQDWESVGTNGESPRARLVAAAAVLAGKSDRSQHFRAYVFGGWDPGTKQDGGDILETIHRLDFGRDQDSGTTNPTWAHLDVVTPGGPTSRHVAVAIPERNQIVLHNHRCHDMVWIFDADRESFVQQTTSGPCPSARGLHSATLSSKHEIVFFGGASQDQTMSNEVFVLDTKSWTWRKLMDNEKKAPSPRASPCLCRWSDDIVLVYGGAESSSLGLTPRSDVWALDLRKETWNCLLPDDQPASTFCPPARNAATLVEMSSSENGKEYLLTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G802</accession>
    <name>B7G802_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">factor independent urate hydroxylase</fullName>
            <ecNumber evidence="3">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_29736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183233.1">
        <property type="nucleotide sequence ID" value="XM_002183197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G802"/>
    <dbReference type="STRING" id="556484.B7G802"/>
    <dbReference type="PaxDb" id="2850-Phatr29736"/>
    <dbReference type="GeneID" id="7194847"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29736"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_1_0_1"/>
    <dbReference type="InParanoid" id="B7G802"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="27047" checksum="E8E569F3F288C348" modified="2009-02-10" version="1" fragment="single">MIVATDTQKNSVYVVAKQNEFHSPEEFGVLLSRFLLTQYPWLEAVDVVVDESTWQRAVVDGQPHPHGFVKSGPEAQHAAVHMARTGETLGPPVIQSSLTCMTVLKTTQSGFEGYYLDDPYTILPPTRERCLATELDAVWTCHGQDPTAVDYNAVRQRVRELFQKGIFGPATTGGVYSASLQATVYDAACLILTELPDVQTISVRTPNLHYLPTTVLLGKLGETFQNDVYTPTNEPSGVISCTVSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G826</accession>
    <name>B7G826_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183243.1">
        <property type="nucleotide sequence ID" value="XM_002183207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G826"/>
    <dbReference type="PaxDb" id="2850-Phatr48673"/>
    <dbReference type="GeneID" id="7194906"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48673"/>
    <dbReference type="eggNOG" id="ENOG502T0YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309615_0_0_1"/>
    <dbReference type="InParanoid" id="B7G826"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="944" mass="107019" checksum="999BB810EF88EBBC" modified="2009-02-10" version="1">MYPSRQRKHVVVPGLLIMTCVSCLLIVLTMEPLKDDGTGRVSWRHTVREGIDSTSRSLDKPTNFVEVIGRLEDAGPLASTPANIHQTNIEVRGTVAPVVEKKTAIAASPSDDDSTDSLAVPLLRPVLEWQTYQQEHSDEVLEYELLHDRLAIRNRRFAVVPYTCPHRVGNFWHNAVHTITWAIVHNRTILLQPYKLQDQDTNCQGRVLIPSWIPLYEKWRFKLALPNPEPWPILTNSVSESGSSALEPAHRDHNSIMVARFPQIPDIDSKETNITRCQWVEDLSRPKFRDYLNHHVAQNKLNPRLTSFLPSRMVELYQEGADFLDGMLFHTVFPLSPSATAADRVNDGSTFSVALHSRHISPGDDGSFLPSEIACLQHLLLNQTTATSCRVVLLSDRDLSIEIMQKWIHTHTNCTVVTASDHRGKADPNVTTFLYKTPAEHGPHAGLGFLDEISMATNSVLDAVVGDPHRSSFEILHKLAIYHRATVDVSGGATNVDAASTPLHFCELPLKKVKGYNYGPNTPMFRHPRNVEPLPAKEILDVYIARHGHDVMQREWEDHGELCATRQFLVVPFDCNSSSTDWTGTNQSSSSMDDWLNGMVWAVITNRTALWTCRTWSSKWRKFVPRKKNEGRPQSFRNTVVENGNQHDKKHPYRTLWRPQPWMTKWETWANQVNVKEESLETFSTLRTSRLARVLRFSSDFPPLPLSTTNPRKTPTGHTSPATEQNTALSLWQFRWDTLFDQGTDYLYGMLHKHTLEWRTTQRPTIHTSDSLSTEEAAGFTVGLIMNQPPRLMSTFTGRQRINRELTDCLDRLLPVTTQASTTNLTRAIALSSSFCTILLVGYPLDTVMEEWLRSFRSNCRLRTSHNKENRMQSSSFSSSGLSRSDADFISQARDGLVVFAEGNSLTATVIRQRITYERTQETWQLGRVPMQLSPLRSCLLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G828</accession>
    <name>B7G828_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183245.1">
        <property type="nucleotide sequence ID" value="XM_002183209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G828"/>
    <dbReference type="PaxDb" id="2850-Phatr48675"/>
    <dbReference type="GeneID" id="7194908"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48675"/>
    <dbReference type="HOGENOM" id="CLU_680563_0_0_1"/>
    <dbReference type="InParanoid" id="B7G828"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="405" mass="44694" checksum="08B719B4DA832CD1" modified="2009-02-10" version="1">MKAWMNRRLATTRVVVITIAGLVGTGCDAWDLRMSATLTLPHRTTATRSLSSSSRRPTRSVSPTISSRGRNDHRSVESTVSARPVVDLGPSVPIPTEPSLPFFLVPKETRTALDFVSLKETDVSLDALFFADRTDASMEHELVDSFPRTDTPTSVVVEDTYTEWIEAVGGAAVGTTVLCLGSGAMDAQGACMAGLMVGVLSGLPEPLSRNPLSAILYQVGYGLSSVTRHSLEAVPFDPNVVQHSTRGAWSLLTEVTRQAQEKVEINWIRPGVGTRSMHATPWMATMAIEPSHKFVSIPRQYRKVDMDDEVHSIRITDGMDRARAKAHQRLVSVRDEWEAATSSLQYRFPSWRDQSRPHLYELASEAERQGWTSSSSLLRTLDDVRALPAQTSVKLSDLRRRTNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G891</accession>
    <name>B7G891_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sugar fermentation stimulation protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183430.1">
        <property type="nucleotide sequence ID" value="XM_002183394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G891"/>
    <dbReference type="PaxDb" id="2850-Phatr48752"/>
    <dbReference type="GeneID" id="7195007"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48752"/>
    <dbReference type="eggNOG" id="ENOG502RYUS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049397_0_0_1"/>
    <dbReference type="InParanoid" id="B7G891"/>
    <dbReference type="OrthoDB" id="199134at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545:SF3">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar fermentation stimulation protein C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="449" mass="49992" checksum="4CB839B74A898741" modified="2009-02-10" version="1">MVSTRRAIRTRTQSQPTKITAASTVPEEDSSGDALCSTPHKRRKTQTVRSTPPSHPLRKPVRQTTVRHNTTATPTLLDGKLVLFSLQDPDPLIRATLRARPSTRNKSPYVADVRLDGEDGREALLHVPNLDMGGKCVVGKTLLIKPARTNKGELVGAEAVSPKYQTPKCEFHAQLLYVDEQEYTQRHPDPPTNGDIPADDDVPEKIHYPPTWVGAHPALGERIARCWLEHNLVEGIPAVTALRTQVRNPCGTDMRVDFLVTHADHTQRIIEVKTVVDTDYAVDATPPAVPASGKRPKKSCVFVSHVRPYTRTAIFPWGNSNQKGPDGEAVVSTRAIHHVRELTRIARERLCWWSPSEEEEEEDKVKTTSTPLLTTILFVVIRGDATAFAPNIQACPSFARYLREAHDAGVQVLAKRVRWGVDEHEGVCVDDDMLPIVWPTPESRREQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8V8</accession>
    <name>B7G8V8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183535.1">
        <property type="nucleotide sequence ID" value="XM_002183499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8V8"/>
    <dbReference type="PaxDb" id="2850-Phatr48921"/>
    <dbReference type="GeneID" id="7195213"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48921"/>
    <dbReference type="HOGENOM" id="CLU_1513427_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8V8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47162">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853027" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="19136" checksum="51CE8AAD2E57341E" modified="2009-02-10" version="1">MARHMNLRGSLRWVFLTLVLLQIACVPSVVVGEGEPTMGEEVQERMEEAMDTAGGYVEEAYESVQESVEETMEPVVEKIDEVVEETKAKVEEVVPKKETKASEALEKIKTKVAAAIGIVVDKSKEVADRAKSMSKQDAKKVAAAALGVWGVSVGVGWLAQTVAKDAPPAPTAGKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G968</accession>
    <name>B7G968_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_39627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183586.1">
        <property type="nucleotide sequence ID" value="XM_002183550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G968"/>
    <dbReference type="STRING" id="556484.B7G968"/>
    <dbReference type="PaxDb" id="2850-Phatr39627"/>
    <dbReference type="GeneID" id="7195379"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39627"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_0_0_1"/>
    <dbReference type="InParanoid" id="B7G968"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="107"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="410" mass="45310" checksum="73EDCA24770FA824" modified="2009-02-10" version="1">MRFVSVAIIVATSSNVEAFRSVPTFSRPASSLSVATDPDKLLFETTRKQVQDYYGQTLQTSDDLATNACCTAGAPPTYIQECLNRINPTTLKKYYGCGLCLPSYDLEGCSVLDLGCGAGRDVYIASQLVGKEGRVVGVDMTPEQLETAKDYQDYHSEKFGFANTEFHQGYLESLDDIDALEKESFDVIISNCVINLCTDKPAVLKACYDLLKPGGELYFSDVYANRRVPETLQKNPLLWGECLSGALYWNDFQNMAKQAGFNDPRLVEDAPITVESKKVQNMIDSEGHSSIKFFSATYRLFKMPELEPACEDFGQAVIYKGTLPRAESGWLLDKHHYFEAGRIHPVCGNTWFMLKNRNLADHFDFVGDFSRHYGIFEGCGSSLPYDLQPASTGKGTSIESNSSGNGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9B1</accession>
    <name>B7G9B1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron starvation induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISIP2B</name>
        <name evidence="2" type="ORF">PHATRDRAFT_54987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183742.1">
        <property type="nucleotide sequence ID" value="XM_002183706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9B1"/>
    <dbReference type="STRING" id="556484.B7G9B1"/>
    <dbReference type="PaxDb" id="2850-Phatr54987"/>
    <dbReference type="GeneID" id="7195419"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54987"/>
    <dbReference type="HOGENOM" id="CLU_851162_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9B1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356734" evidence="1">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="34655" checksum="7398FB7B2BF07E08" modified="2009-02-10" version="1">MKILLLNFFTAAVAAQQMEIARFGGCLNETQVALEAAGTSDGVSPFSCHMESAHCGEGERWLTPMDVESEGFGPCGCDEDYDTNAYIGTCYDLSGSHQVVCAYDGSQCPENWMDLGQRFNNDHEIDESCNDESNASDNEESSCGKRCLCNYHYTSRDGPVDAGTSTYGICYNSESRTYECAVANHSCAEGEEFFGPHEGIDQYGAICNCDDTAVGACMEGGSTFSHCAVFEDSCGAGQSFTTARQLSSMSDMPSCRLCSNTWEGETPAPMAAPVSSPVSAPVNNPVSMPVSSPTNSVTAEDGGSGAFVQGSTVLMSALLYTVLSFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA16</accession>
    <name>B7GA16_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183991.1">
        <property type="nucleotide sequence ID" value="XM_002183955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA16"/>
    <dbReference type="PaxDb" id="2850-Phatr49267"/>
    <dbReference type="GeneID" id="7195561"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49267"/>
    <dbReference type="eggNOG" id="ENOG502SQMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1424042_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA16"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="60"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="252" mass="27552" checksum="3288B75B8C647415" modified="2009-02-10" version="1">MAKYYKRSRRLFAIRSGFNVSLLFAPLVHSLVSFTSFRFAANGVCISPARFVDVDRPQTFTMKNVPGEGDCMFLAVALATLASMGLGGNDALLRAISHETREAVASTLEQPGILIIEGTRTVSTESLLKSAARQENLSTEEYLRLLRVEGVDGGLYGGGPELTVLCNILRRPISIYELDEQQVGTNIDIQPIKCKGVFGLETFQDPLFDIPNSAILLSKSLPGAYSWHLHILVLDVSPTEKHACVLLPLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA53</accession>
    <name>B7GA53_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6816 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183888.1">
        <property type="nucleotide sequence ID" value="XM_002183852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA53"/>
    <dbReference type="PaxDb" id="2850-Phatr49300"/>
    <dbReference type="GeneID" id="7195580"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49300"/>
    <dbReference type="eggNOG" id="ENOG502S6QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786066_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA53"/>
    <dbReference type="OMA" id="FCNARES"/>
    <dbReference type="OrthoDB" id="195555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049213">
        <property type="entry name" value="DUF6816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20670">
        <property type="entry name" value="DUF6816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853055" description="DUF6816 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6816" evidence="2">
        <location>
            <begin position="89"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="310" mass="34667" checksum="F141C95305A00B32" modified="2009-02-10" version="1">MVLRFLVAMVGCWHGLVPTHSLDLRRHATTSVAMDRRHLLRQTLGILPIATSVVTVEKVNALEANGLAARLQKKDPALLKNRIFNIPPAAQVYPSWLRGSWKVSSNLNGYLFPSRKITKERVTQNPVVPGFQKCSVVTTADIGKEGVEYVWRIDASTGLEDRTANFPAAINAYLGYKAVNDVVYDARANPNRISIDFVDYKTVNAERVELFCNARESETYTDATTNEPIFVCREYARQVTFGAGSTVGVPRQVGTNYAHFWTWKQQGTDRIVGNLLTAGFLDPQDSLYFEEPTLPVVIYSHLMKGQRIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAE7</accession>
    <name>B7GAE7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184062.1">
        <property type="nucleotide sequence ID" value="XM_002184026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAE7"/>
    <dbReference type="PaxDb" id="2850-Phatr40078"/>
    <dbReference type="GeneID" id="7195773"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40078"/>
    <dbReference type="HOGENOM" id="CLU_1079525_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAE7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="258" mass="29503" checksum="45BDF3FA10F0D907" modified="2009-02-10" version="1">MVEVVTVESRPRRSFGGLFKIRSSKSEFGMDTSFATATTVFDDSCTVSRRSSGSSGHFTYPSNHSKGWARAMNYLRRRSPSTIIVDTEDFEEDIRNKNSSANRVHDFFAKELNRCEPNQLRLLREQREEGTRVVITEDDDDDDDKDTNSASNASAVAESEKSIDCESSSADIALQSRWQALDIQRRLLGAKHPDVQFLERQIRRRVVVTRAHNRCGDSFLLSPRHHRHQSAQSERANPYYPYNEPRFSPAFVPRPSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAJ1</accession>
    <name>B7GAJ1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184205.1">
        <property type="nucleotide sequence ID" value="XM_002184169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAJ1"/>
    <dbReference type="STRING" id="556484.B7GAJ1"/>
    <dbReference type="PaxDb" id="2850-Phatr49421"/>
    <dbReference type="GeneID" id="7195911"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49421"/>
    <dbReference type="eggNOG" id="ENOG502S59I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_744885_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAJ1"/>
    <dbReference type="OrthoDB" id="44749at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="372" mass="41651" checksum="4E1A4F49B2C54140" modified="2009-02-10" version="1">MKIASGWRERLRKMSTGKRLTVLVTIFVLLTWHSDALLKPLANNGRKIDQSSSLLFLAPRNTQADSEGSNIGLTKITRRTLCHELTMLPALVGYTIFLPAGVLAAQPITQGEADNVGARIQRTLRPKPTKILRPKLDKDFAVMLMRSSYNVLDDLDCVPMEQFQRDFFIIRSAEYEPYIKNLGYGLVQQGDLTDPYYFDFISFAQYLTINRELTQSPLMVYEEMQPVDVSVGEPQQFVSKIVRRNPDITNDQLVPEHSRRVGAAILDRFEDLYGSTKSEIPLINAGSRPSAGAVSSIQLNPHQCICANQVIDAFDQLVKIFLLNGYAWDGMAKIVSSGPKGTEFCLTLISPATIWGGQSLQFGKNKLQNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAM7</accession>
    <name>B7GAM7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184221.1">
        <property type="nucleotide sequence ID" value="XM_002184185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAM7"/>
    <dbReference type="PaxDb" id="2850-Phatr49453"/>
    <dbReference type="GeneID" id="7195811"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49453"/>
    <dbReference type="eggNOG" id="ENOG502SAFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1306852_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAM7"/>
    <dbReference type="OMA" id="VDACCEN"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="200" mass="22427" checksum="915BB7F69FB81536" modified="2009-02-10" version="1">MDGVEDAQDTVVRLETLDQKHLPQVADLFREAFANKRCCGVFAVAESVAGMQKRYASYSAEKFQLGVVALRGDEVLGFCQMTTRKLPMYPSGAHHCEAGEMYIETIAVSDRARGQGIGGKLLRWSEEKARAEHMKKLTLEVFQGNRAIGLYERFGFKIVPPDGDCVDACCENVTVCCFFGRPYGWCHPKWGTHIMIKHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAR9</accession>
    <name>B7GAR9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_40200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184124.1">
        <property type="nucleotide sequence ID" value="XM_002184088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAR9"/>
    <dbReference type="STRING" id="556484.B7GAR9"/>
    <dbReference type="PaxDb" id="2850-Phatr40200"/>
    <dbReference type="GeneID" id="7195833"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40200"/>
    <dbReference type="eggNOG" id="KOG1249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365829_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAR9"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="455"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="NOA1/YqeH-like C-terminal" evidence="3">
        <location>
            <begin position="582"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78153" checksum="B0E298F7A9149020" modified="2009-02-10" version="1">MRTNFALSTRCFASSSDNHDEEEQRDSPKQRSKRSQTNRSKKFKIAESIDQSKIDKLAQAFDELARKEGFDSSTARFADDVTFEDKFDDDSFLDDDDDNNKDKVGNLHLDASMFSLSDFIDKSEEDGGNPTDQDDEDYLDFGADIDMSIEARIAAAKRDMDLGRVSAPPDMRSSRREVTAADLRKLGFRTEANPFGNDETPRKERFQLVTNSMSCSACGSDFQCHNEDRPGYLPPEKFATQTALGKIEQMQKLQDKAEKAEWTPEDEIEWLIQTQGKKDPNKEMQEVPQIDVDSLAGEMGLDLVELSKKMVICKRCHGLQNFGKVQDSLRPGWTKEPLLSQEKFRELLRPIKEKPAVIVALVDLFDFSGSVLPELDEIAGENPVILAANKADLLPSEMGRVRAESWVRRELEYLGVKSLAGMRGAVRLVSCKTGAGINDLLEKARGLAEEIDGDIYVVGAANAGKSTLLNFVLGQDKVNRSPGKARAGNRNAFKGAVTTSPLPGTTLKFIKVDLGGGRSLYDTPGLLVLGTVTQLLTPEELKIVVPKKPIEPVTLRLSTGKCVLVGGLARIELIGDSRPFMFTFFVANEIKLHPTDIERADEFVLKHAGGMLTPPLAPGPKRMEEIGEFEDHIVDIQGAGWKEAAADISLTGLGWVAVTGAGTAQVKISVPKGIGVSVRPPLMPFDIWKVASKYTGSRAVNYNFSLSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAU4</accession>
    <name>B7GAU4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
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                <person name="Medlin L.K."/>
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                <person name="Robison M."/>
                <person name="Rychlewski L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CCAP 1055/1</strain>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
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                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
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                <person name="Jorgensen R.E."/>
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                <person name="Kaplan A."/>
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                <person name="Siaut M."/>
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                <person name="Wyrwicz L.S."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
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                <person name="Otillar R.P."/>
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                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">CCAP 1055/1</strain>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
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                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
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                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184325.1">
        <property type="nucleotide sequence ID" value="XM_002184289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB89"/>
    <dbReference type="PaxDb" id="2850-Phatr40369"/>
    <dbReference type="GeneID" id="7198261"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40369"/>
    <dbReference type="eggNOG" id="ENOG502T2TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932102_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB89"/>
    <dbReference type="OMA" id="VAFLEIH"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33170" checksum="967E3E9DBEB16803" modified="2009-02-10" version="1">MSRIPNGGDIGNLPTLDLHGFRRERAVRDTVAFLEIHQTSWVIVITGSGRHSPEGPVLRGAVESILQRRGMQFSRNTPGTFLVNAATGHSNYYYQDGCAEDTKVVVRDANEEEVAVQLAMRKTTRGYCGTASGRALHRSSSSSGSSENCLGTGPSLVEVARADQELDQARAESLQLVREEASKYKREAKAIRKAVAKSIDEVRKYEDEEEELLRKAVQLSEEQEASEREEEERILREVLRESEKDSKSSCHSDDALREAILRSDCEYNPLASDDSDEASMIRQAIALSLADFHSAVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBB9</accession>
    <name>B7GBB9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PK6</name>
        <name evidence="17" type="ORF">PHATRDRAFT_56172</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184341.1">
        <property type="nucleotide sequence ID" value="XM_002184305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBB9"/>
    <dbReference type="STRING" id="556484.B7GBB9"/>
    <dbReference type="PaxDb" id="2850-Phatr55079"/>
    <dbReference type="GeneID" id="7198297"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56172"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="InParanoid" id="B7GBB9"/>
    <dbReference type="OMA" id="HQISALW"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="15">
        <location>
            <begin position="59"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="16">
        <location>
            <begin position="444"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="556" mass="59775" checksum="8572510477D36967" modified="2009-02-10" version="1">MFRRAVLSLSTRAIRTPVPCSVARGGASQVRSLAQTTFYLPDPADRSQDVHNRGNLQLSKIVATIGPTSEQEEPLRLVTDAGMRIMRLNFSHATKEEVELRITNLALAQKALQPPGTLEMQDVRALLLDTKGPEIRSGKLAHDESGHATVTLQQGQRIELFNDASRQQQSGSTEQALYIDYPGLHRCLHPSMKVLLDDGAITLTVQSVNVEAATVSCVVDNAGELRSRAGVNLPLADTSDLPAMSDKDKQDIKYGMTMDIDYVAASFVQTAEGVNEIRGYIQQCAQELGWDDSHPLPLIISKIETAGALQHFDAILAASDGIMVARGDLGVEIPLTQVTNAQKEMVAACNAVGKPVIVATQMLESMAKSPRPTRAEVSDVTNAIYDGADCVMLSGETAKGKFPTEAVRTMNEIILAAERYTTSGALGHSYHRPAFVGPKTADSAVAKAAVTASVERDCAAILVLTQHGSLPPLVSAYRPRVPIFAFCPTPKLARQLQVYRGIHPIVDSTLTDGNDCKRPEQAVQEAKDMGLLQSGDEVVVVSMDGTTATMKIAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBL7</accession>
    <name>B7GBL7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184548.1">
        <property type="nucleotide sequence ID" value="XM_002184512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBL7"/>
    <dbReference type="PaxDb" id="2850-Phatr49827"/>
    <dbReference type="GeneID" id="7198488"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49827"/>
    <dbReference type="eggNOG" id="ENOG502QUIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738714_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBL7"/>
    <dbReference type="OrthoDB" id="190552at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="416" mass="46205" checksum="3ADB94E67154A387" modified="2009-02-10" version="1">MMSSDPSALKPSKRARTQRSISSTLSADPKSRADISSRTQEMNQRAKDGAPLSETELRDVINSVQNVYPSETDMSWEDLRTVLKDVAHLSHKDWAVTGNNAKRLGEKLLQDGVSKSSRQLLERILTEGKWDEGAKHATERPDSVQPWAVLVTGVNGIRKTTSIYQTWFPNLLGEALVAPDGAKTDFSNQVLPVGSNSFFRQLDHMIATLCNEDFGLLYSMTSELLDEQMLKDPPRDVIKKYSDLKAAIFTRYRTLAELLGALLLTEAQLVKSNCMMETSGRDVAMFNYVDHFFPKGYSKLALHFTVNDLSQAKESVDQRMVREIQTGINAVKKESVFDIINANAGGPYGSEVLEGIQRDSDKVWNTVLDGSAGVGKDWYKATIRINAKANEPWTAQAVKPDGSLGAEFVFEKSPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC25</accession>
    <name>B7GC25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184642.1">
        <property type="nucleotide sequence ID" value="XM_002184606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC25"/>
    <dbReference type="PaxDb" id="2850-Phatr40659"/>
    <dbReference type="GeneID" id="7198670"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40659"/>
    <dbReference type="eggNOG" id="ENOG502SY13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822490_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC25"/>
    <dbReference type="OrthoDB" id="43550at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36345" checksum="71EC0EAA7BCBF4FE" modified="2009-02-10" version="1">MTGTTVLPRGFKSLQKWLQVEKSRFSASPILLLESTPHHQASNPHVAKACQHVKFLLSQQLGFRVVQGRPAGAYPTSEDVIKQLEMAARVGAGTVVAVGSGTAMDLAKTLATSVDEILMIPATYGGVLASSTPHALLLDAKEETLVLPHNDNSWNGSEQQQSASCPRTIGLLEPNLMETGNFHDAALATISLLLDAAYRKVLPEETLPKYVDKLLSHDGPDDEYLLYALIKAGQDTSFGLESQDRSIPIALLASLLPTSFADQSTLTFLAGLAPSMHSLTGADAVDPSKLQSAPKLIVANETVADLMALVRTNQSLWRCRDATSRAFLTVLNEHVLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCA9</accession>
    <name>B7GCA9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M6-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184771.1">
        <property type="nucleotide sequence ID" value="XM_002184735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCA9"/>
    <dbReference type="PaxDb" id="2850-Phatr49918"/>
    <dbReference type="GeneID" id="7198617"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49918"/>
    <dbReference type="eggNOG" id="ENOG502S1RF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419499_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCA9"/>
    <dbReference type="OrthoDB" id="9986966at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M6-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="652" mass="71120" checksum="0C553E118157E949" modified="2009-02-10" version="1">MAGQSLISRCQAFAPPPTVDTNDDWMPVDAYRQQHGIQFEYEPRHISPEVCRYLNETECAQEDKAARETYQRHLRTMESLRRRRLQTTPATSKGSFKAMVLLVQFADHQNRPLPSKEYFEELCNGAGTSTVNPIGSIKSYFSEQSQGLYDVDCEVFDWRTTTYTEADAAQGISGILSNANAQKFFHPVLDQIDAEKVASSGDFWLFFEGFDADGEDGMGDGFIDALVVIHSGFGAQVAEICDGVRRADRIWSQGRSTSEGFGWNPRNIEVGSYSIASAFERCSTDRPALMGVITHEWYGQIAFLFAEILSFFVGTNRLHTFGVPDLYGKNNFRFGGIGSFGMMSSPYGQTGDGSTPGSLVPWTRNRIGWLEYNEITTDGTYSVSGLQAYAIRDKFPADEFLVIECRFPSSFDSDFWGIGGIVFYHIDDKMGGQDRPGWPGQSGWPANGNHYQVAVLQADGRYDIEQDVNSGDIDDLWVDGMALRPNGGSGIFPNTDSYQGTPTVTGITIRIVSSPGKTMQFVVEGLASNPNQLSLPTPFPSGLPSHSPVIGIAATPFASPSQSNPYPLCTSSITENCFDQPTAAPKDSKPCVPGMGVVCSDGTSDPQTAPTIAPESSKDETTGQEDALTSSAPKLGDMLVLVVSAVTIVVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDA6</accession>
    <name>B7GDA6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ketol-acid reductoisomerase, chloroplastic</fullName>
            <ecNumber evidence="7">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PHATRDRAFT_30967</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="7"/>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185094.1">
        <property type="nucleotide sequence ID" value="XM_002185058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDA6"/>
    <dbReference type="STRING" id="556484.B7GDA6"/>
    <dbReference type="PaxDb" id="2850-Phatr30967"/>
    <dbReference type="GeneID" id="7198894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30967"/>
    <dbReference type="eggNOG" id="ENOG502QQBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_5_1_1"/>
    <dbReference type="InParanoid" id="B7GDA6"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000015">
        <property type="entry name" value="Ketol-acid reductoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000146">
        <property type="entry name" value="Ketol-acid reductoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 22" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="15 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0934">Plastid</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853248" description="Ketol-acid reductoisomerase, chloroplastic" evidence="23">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="24">
        <location>
            <begin position="61"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="25">
        <location>
            <begin position="260"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EEC43541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="539" mass="58837" checksum="9F788C39BA0F582C" modified="2009-02-10" version="1">MKFSTLTAAFFVASATAFQQPAFAPRSVVAQSSTSGLHMAFESKIFETQEVTFADTKEIIVKGGRDLFPLLPKAFEGIEKIGVIGWGSQAPAQAQNLKDSLKEVGADITVSIGLREGSSSFEEAKDCGFSEEDGTLGEMFSVIKESDLVVLLISDAAQAKLYKEIFAAMKPGATLGLSHGFLLGHLDSIGEKFPENMDVIAVCPKGMGPSVRRLYEQGKDVNGAGINSSFAVHQDVSGKATELALGWGIALGSPFMFETSLRSEYCSDIYGERGILLGAVHGIVESLYRRYQRQGMSPEQAFLESSESITGNIVKIISTKGIKAVYESLDGDDKETFQKAYSASYKPAKEILQEIYDEVSSGNEIRTVIMHGARIDKYPVGKIDGTDTWKVGEKVRAERDEDKIPLNPFTAGVYVATMMAQIDVLLEEGHPYSEVVNESVIEAVDSLCPYMHYRGVAFMVDNCSFTAKTGSRKWAPRFDYILDQLAYTAVDNGAPVNEQLIADFEKHSVHQAVEECCKLRPAVDISLFAETSTKEIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDE9</accession>
    <name>B7GDE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185200.1">
        <property type="nucleotide sequence ID" value="XM_002185164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDE9"/>
    <dbReference type="STRING" id="556484.B7GDE9"/>
    <dbReference type="PaxDb" id="2850-Phatr50239"/>
    <dbReference type="GeneID" id="7199095"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50239"/>
    <dbReference type="eggNOG" id="ENOG502QUQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734599_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDE9"/>
    <dbReference type="OMA" id="NELEYWR"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42506" checksum="57337F8EB3D6EE98" modified="2009-02-10" version="1">MDVEVEMVRSTDPPGRDGLLVSAKAVETTFPHTISSRMRRPSICLMVMVLTIFVAVVGKIYLDPEGLITIRGGVYTPEEGTIGKSAGTKVAEAMGQIRNRKGHGNTAERLNNRHKIETSETYPTNIDPEDTAQTWFAANVTLKDGQKYEIIEKLGHDRSAFTEGLTFAKGFLYESTGMNGRSSVRVLDPATGQVMESYPMSPQLFGEGMTFMNDRLVQLTYKAKTGFIYNANYLTEEPETFPFSTTRNEGWGLTYDHRNNELIASDGSNKLHFWDALTLTEVRRISVYRQDGSPATNINELEYWRGRVLANVWFEDVLLVIHPESGVVEKEYDFSSLWPKRERHSMGADVLNGISVSSDPDILFMTGKNWDRMFRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDJ2</accession>
    <name>B7GDJ2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_16711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185222.1">
        <property type="nucleotide sequence ID" value="XM_002185186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr16711"/>
    <dbReference type="GeneID" id="7199117"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16711"/>
    <dbReference type="eggNOG" id="KOG2183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020959_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDJ2"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="283" mass="31671" checksum="BA18558E3135B194" modified="2009-02-10" version="1" fragment="single">MTCGFFQQALNHFDLPRGQSGTYQQRYCVYNDFMVNETSAPIFLYTGNESPLEQYINHTGLIWESAEAFGAQVVFIEHRYEGQSLPSPFISSCMAYSSTIQALADFARFVELKLFVDTGDFSRLRRRPVIAFGGSYGGMLSAWLRMKYPNTIAGAIAGSAPIWGFPRNFPSKIDAAYRVIQHGLQQSYPPTLKPLDNNHCATNLLATWPLISALAQHHEGLQLLTSSFRLCEVLKDGDTLIDWAQSPWFDLAEGSFPYSSSYIPFALTHKDAKLPAWPLQAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDY5</accession>
    <name>B7GDY5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GLRX1</name>
        <name evidence="6" type="ORF">PHATRDRAFT_16854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Grimwood J."/>
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                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">CCAP 1055/1</strain>
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            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
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                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="McGinnis K."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
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                <person name="Detter J.C."/>
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                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <source>
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            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
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                <person name="Maumus F."/>
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                <person name="Mock T."/>
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                <person name="Berges J.A."/>
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                <person name="Medlin L.K."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
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                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="DS999268">
        <property type="protein sequence ID" value="EEC42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176204.1">
        <property type="nucleotide sequence ID" value="XM_002176168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3R4"/>
    <dbReference type="STRING" id="556484.B7S3R4"/>
    <dbReference type="GeneID" id="7204969"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd383"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021668_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3R4"/>
    <dbReference type="OrthoDB" id="36608at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="39706" checksum="C290E6330F298CEA" modified="2009-02-10" version="1">MSLGRDDLRKRWRVEFLGEPGMDVGGVSREWFQLVTEQIYDPDFGLWLSSVNNQMCMNINPSSGMSCPEDHFIYFRFLGRILGRALFDRQVVKGHMVRTLYKHLLGWPITFEDIQSQDEEYYQSLKKLTKMEDVSLMCLDFTATEESLGVRTEVDLVEGGALKEVTNENLAQYLEANLQYRMLGRIKPQVTELLLGFFDIIPEPALTVFDANELELILCGLPEIDMVDWQQNTLYSGMFEGKGCSSEVVTWFWEIMKEDFDQEMRARLLQFVTGTSGVPSRGFAVLQGIDGNIKKFTIHGVDSCNYYPKAHTCFNRIDLPLYASKKELFDRLKTAITMSGVGFDME</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0A8</accession>
    <name>PETN_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome b6-f complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytochrome b6-f complex subunit PetN</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytochrome b6-f complex subunit VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">petN</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast thylakoid membrane</location>
            <topology>Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PetN family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874383.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0A8"/>
    <dbReference type="SMR" id="A0T0A8"/>
    <dbReference type="GeneID" id="4524700"/>
    <dbReference type="InParanoid" id="A0T0A8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009512">
        <property type="term" value="C:cytochrome b6f complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00395">
        <property type="entry name" value="Cytb6_f_PetN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036143">
        <property type="entry name" value="Cytochr_b6-f_cplx_su8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005497">
        <property type="entry name" value="Cytochrome_b6-f_cplx_su8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03742">
        <property type="entry name" value="PetN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103451">
        <property type="entry name" value="PetN subunit of the cytochrome b6f complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000275572" description="Cytochrome b6-f complex subunit 8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00395"/>
        </source>
    </evidence>
    <sequence length="29" mass="3265" checksum="BB5DCB1B6094C5A3" modified="2007-01-09" version="1">MDILSLGWAALMTMFTFSLALTVWARNGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2024-11-27" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0G5</accession>
    <accession>Q5D709</accession>
    <name>SECA_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">A minor fraction is associated with the chloroplast thylakoid membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874440.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0G5"/>
    <dbReference type="SMR" id="A0T0G5"/>
    <dbReference type="STRING" id="556484.A0T0G5"/>
    <dbReference type="GeneID" id="4524563"/>
    <dbReference type="InParanoid" id="A0T0G5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17928">
        <property type="entry name" value="DEXDc_SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1440.10:FF:000003">
        <property type="entry name" value="Preprotein translocase SecA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3060.10">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21090">
        <property type="entry name" value="P-loop_SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000318488" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence variant" description="In strain: UTEX 646 / Bohlin.">
        <original>S</original>
        <variation>G</variation>
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: UTEX 646 / Bohlin.">
        <original>QD</original>
        <variation>HE</variation>
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: UTEX 646 / Bohlin.">
        <original>D</original>
        <variation>G</variation>
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: UTEX 646 / Bohlin.">
        <original>D</original>
        <variation>G</variation>
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: UTEX 646 / Bohlin.">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <sequence length="886" mass="102221" checksum="62C9BFBB06CE129E" modified="2007-01-09" version="1">MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0L2</accession>
    <name>PSAC_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Photosystem I iron-sulfur center</fullName>
            <ecNumber evidence="2">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">9 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">PSI-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Photosystem I subunit VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">PsaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psaC</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>reduced [plastocyanin] + hnu + oxidized [2Fe-2S]-[ferredoxin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 2 [4Fe-4S] clusters. Cluster 2 is most probably the spectroscopically characterized electron acceptor FA and cluster 1 is most probably FB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The eukaryotic PSI reaction center is composed of at least 11 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="2"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874487.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0L2"/>
    <dbReference type="SMR" id="A0T0L2"/>
    <dbReference type="STRING" id="556484.A0T0L2"/>
    <dbReference type="GeneID" id="4524701"/>
    <dbReference type="InParanoid" id="A0T0L2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000001">
        <property type="entry name" value="Photosystem I iron-sulfur center"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01303">
        <property type="entry name" value="PSI_PsaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050157">
        <property type="entry name" value="PSI_iron-sulfur_center"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017491">
        <property type="entry name" value="PSI_PsaC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03048">
        <property type="entry name" value="PS_I_psaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24960:SF79">
        <property type="entry name" value="PHOTOSYSTEM I IRON-SULFUR CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24960">
        <property type="entry name" value="PHOTOSYSTEM I IRON-SULFUR CENTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0603">Photosystem I</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000276009" description="Photosystem I iron-sulfur center">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01303"/>
        </source>
    </evidence>
    <sequence length="81" mass="8782" checksum="44DE4CEB35E2BA40" modified="2007-01-09" version="1">MSHTVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKAGQIASSPRVEDCVGCKRCETACPTDFLSVRVYLGAETTRSLGLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3A7</accession>
    <name>B5Y3A7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185814.1">
        <property type="nucleotide sequence ID" value="XM_002185778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3A7"/>
    <dbReference type="PaxDb" id="2850-Phatr46637"/>
    <dbReference type="GeneID" id="7204569"/>
    <dbReference type="KEGG" id="pti:PHATR_46637"/>
    <dbReference type="eggNOG" id="ENOG502SV12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y3A7"/>
    <dbReference type="OrthoDB" id="49182at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="753" mass="85380" checksum="5E433429021A251B" modified="2008-11-25" version="1">MPRSKPAQPRSRKLTSKPGKKEHSSPRPEPIEGEAHKQFSTDSQSIHSSYSESRLERFAVKASAITSPHKNMPRRRGLNRAILAEKKIKDKSDSKRTPRLCRTGSVDGDNFPRDESFDTSDCKSSAGSESGNDDSSESVTPTRRSNRQRLPKPVNFSHEDEALEKHSPRKRRLERRLLAKQRKPMGKSSDQDNVLTSESIHKRRRPMVRKSIKSAFPAIGESTRKALKNVTLLGQSNVDASVPPQARRRSTKRTQNEDEDDFVVTSGDEEEGEDMNHTQSDDSEDLLSSDNSDHFQTQSNHGVHHVESDGIGSADESSGTEENETAIYSSPQLTFISRGDTSVKPSPFHDSTDDNSDDSSNQRHRLSPPKLPNCTSRRDTITDEPLPEKHVCFFSPDMESRQCFCLATLRKIALSASRPKYRTDQTGTERQTFLQPPHFRTAMSDDLLDQIASRFGREALDLYGSFYVQRNTRDIAEKEDAGTFEERSQQDEEGFLNLVRTTDGLLQRYIKNTSYRTFQGQLKNYWFDGNNESFVYLLSLLHKAGRARELVKQQDHSDFDDACQYIEPAVKFFHSFADHALELWDLISGPYARDDEEDMGDFLDESNADDSDGGHRALAMEEARQEMEIDQHLIERYTQLEETESDRSVDTYESDVANGGVFEESSEEEDEWEQAIKDRRASFGARSDRAKLASGRKSSDTGELERGHRLHKKAMKDSSSDEEFKAADSQLNVRALRSGLTPRRLAIEDSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3K1</accession>
    <name>B5Y3K1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_46716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185672.1">
        <property type="nucleotide sequence ID" value="XM_002185636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3K1"/>
    <dbReference type="PaxDb" id="2850-Phatr46716"/>
    <dbReference type="GeneID" id="7204503"/>
    <dbReference type="KEGG" id="pti:PHATR_46716"/>
    <dbReference type="eggNOG" id="ENOG502T7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036131_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3K1"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31781" checksum="900EB6A8DE4C658B" modified="2008-11-25" version="1">MAGSVGKDGNIAQKTMPYQDVKDRFARDGFVSIRGILPTDIVEEWEDFGIEFFRKTFEHLHEYGHTAYPEHCRMRNGEKEFALGLGVKSGFREIVMRSPGRYEISILNSVKAGQGMPSLVRIKDLLAETVPILLEERSWESLSVCNLSFVVSTPGSKEQAWHADGGHVSLREHLPCHVFNIFVPLRNVSLQMGPTEFRPGSHIYTRNLAPMMLAAKARKTLRAPAAPLLNRGDILVFDYRVLHRGLANRSGCNRSFLVLTVSKPWFKDILNFPARSMHSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y452</accession>
    <name>B5Y452_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185779.1">
        <property type="nucleotide sequence ID" value="XM_002185743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y452"/>
    <dbReference type="PaxDb" id="2850-Phatr46901"/>
    <dbReference type="GeneID" id="7204736"/>
    <dbReference type="KEGG" id="pti:PHATR_46901"/>
    <dbReference type="eggNOG" id="ENOG502R949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452349_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y452"/>
    <dbReference type="OrthoDB" id="42226at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="591" mass="64662" checksum="94566BA5ECDFD01A" modified="2008-11-25" version="1">MTETTTVGSDVSSGSFTAPDLDCSGAWIKDPTLSDVLCGRGGSINSHAGNERFRELVEKRKRVYLTARFKREKRLIASSIVSEIRGLKPSGRFLSRDSKTGLWKDIGDEKARDKTSQALRENAPSIRAEIETEISEQRRDYQQEDQEVAPHGTSHPGYYAPPTWGFPTYAYPSYHQVHPAPPGGAQPPHGTPMPPPGYSYDPRGPPLPPQHYPPHYPPPGYSRDSHYPPPHSHHHTPTTQPTAQATPKSALEATAEIITSGAETLKKWTHSNLSLTGVPSNDGHDSRSTSSRSSKPIAYVHQDYTKKRRMVKFRDDYDRRTSYSPVFSGSALGGGQAHNEQIEPQNLHDQESSLMTQVADRILGSLGSWDTGTFCGGHDADDERKSFFPVSLSSNAGPPTQDEDNMAVEWEGQEVQLVDKSLESQSVASDERMPPPLVRQQPRPDQASSLGGFSSLGSCHSWLLPESAASYFSKSGASPSNSVDMGYSAVGMEQHSINGSIGGASLTRVFENEPQSTPHSPGMSLRSLSQMPSWERSLRSKSPLSIASDEDDSLISRSSSKISDGHLSPFHAPSSPMPMVNEDDMVWETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y456</accession>
    <name>B5Y456_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_46904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185947.1">
        <property type="nucleotide sequence ID" value="XM_002185911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y456"/>
    <dbReference type="PaxDb" id="2850-Phatr46904"/>
    <dbReference type="GeneID" id="7204446"/>
    <dbReference type="KEGG" id="pti:PHATR_46904"/>
    <dbReference type="eggNOG" id="ENOG502QQYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277806_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y456"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336:SF3">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336">
        <property type="entry name" value="OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="719"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127291" checksum="18D7AD61AE945108" modified="2008-11-25" version="1">MNTQSSTFDERGSRRVSSMGTFRSSFGRSLSFWKRHESGVSRSAMEGSVRALGSESPPQTNLLARRIGSCWSVWPPESRKSFWRRIFTSRLWRFLLVVFSILLLFGAQMRTLLLPKSTDLFVDLLFTVMFFFFVADIAMRVDAEPNYFGMRVWCRTPESASEHINMEGCGNCELGSFIFWCEVISTLALLYEISFIAKDNFAERDMVIRLNEFGAPNGGLDGVNEAIPVERELDLIVIIAKTARLARFIKSSTAVNLSSRIPWYWILKRIHPGHLFGAVRRFVCCCSERSKSGREHDRHAMPGESTLARHTSRRGLGMKVLANAKKEAVEKEYQRAQTWKDYPIRALRFVGILKKDNAEWRRQLAATKIQRAWRAVLFQRHCDEGDDVSGYVSNDYAWKARSAGNNAMEKALKKKSILSHFNQMNSRGILIASGGIQKVSDVTVVTESTNTLRRGPSREELKVGSAMRELTGQRVALGIIFSLVLSSIFTYTEHNATRPATMIVLHNQTGNPAFAERALTAARSSAVPNLFEYHLASGDIERFTLDEWEKPTNLRDKEKIRITIIDFSDQLTVGRFAIKRKSMADAVVSLLATIFVILVWFFGVTAFAGPVMVLVVIPIERMVRLLGMLMLDPLGYQSTSRYKRYITDENEITKNTFWSREILKGMETSFLMSTILRIGSLMKVGFGSAGVDIIRNNLEKGQSKNMLILDSQGITVSCIFLFCDIRQFTDATECLQEEVFVFTNRIAAVVHSICHSYGGSANKNIGDAFLLSWLLDEEGGTSAPSSVSFDAPGYRKAEEFIAKHHQADKALLSVVKICMALHHDDFYISTMSEGARAALLSKLSNRSGPVVQLGFGLHAGKAVQGAIGSQRKIDATYVSEAVELAEFLESSTKKYGLKMLMSDTFHRLLHPNNRRRCRKVDQILIQNDDGGDEEEMEGDKIELLTFDMDIGALWQGANSRHLRKDHSVRSDAGQESDTESASDSRIKRDLGRKVMRRHSRRLSTRDVLNDELSETGLRTSGTAGDSQTDVIGDGQGTNAPPQLVLPTGPALYNSNVWVSKEIRLIRNLYTDGLFFLTFNSGLQAFYAKDWVTAKTNFAAILDRFEDGPSKYFYDQIIKHKGTPPKDFRGYGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4D0</accession>
    <name>B5Y4D0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186269.1">
        <property type="nucleotide sequence ID" value="XM_002186233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4D0"/>
    <dbReference type="PaxDb" id="2850-Phatr43804"/>
    <dbReference type="GeneID" id="7203945"/>
    <dbReference type="KEGG" id="pti:PHATR_43804"/>
    <dbReference type="HOGENOM" id="CLU_509502_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4D0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841118" evidence="3">
        <location>
            <begin position="24"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="535" mass="58452" checksum="C5BFF12AB78E5F8A" modified="2008-11-25" version="1">MAQSSLISLLSVLAGLGLPLASAIKGDVSKAKLGKRPRRSLKSKSKSSSRHKYFHGDYMLGQEAFMFHCQLELAEQANYGPLSEDDFGDFIFDYCKKIPLAGIECKFPKGKSFAHLPVDLQLSFFEDQCLSAAKDEAEECLQTLINEGIEFENQGDIRKLCGKVYPLLLSNKLFAPEPASDAQLDTEGSSPSGPPSAESRPSTVPQAHQTSNFIPTAGTVLTTNNISSPAPTKTIDLTDSTAAPEINRRGISNSGTIGIAGAAVVSLGLLLVSWMRRRNRVASRNKSEDDPMFDNDESILSESTEILDSNNTGLGDLDNQLSQSKKPSLSMATIVHPGRCVKLLALPRELSYKSAPDTASAHEIEGGDVEWEIRDEEAALPIVNLIECHSGRTLSGERSGALVNKSSESSRTAPICHSTDRRPWRSKKKGKFERVFRNCQRIKPQREAIVGEIAMSVKDNLFVRKGKALRKQRLLEEQSQDDDLSSDGSIDSLSVNDSISHGVKKQFQDFDAILTKGFNELKSEMESTDGLACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4D9</accession>
    <name>B5Y4D9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long chain acyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACS3</name>
        <name evidence="4" type="ORF">PHATR_54151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186275.1">
        <property type="nucleotide sequence ID" value="XM_002186239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4D9"/>
    <dbReference type="STRING" id="556484.B5Y4D9"/>
    <dbReference type="PaxDb" id="2850-Phatr54151"/>
    <dbReference type="GeneID" id="7203948"/>
    <dbReference type="KEGG" id="pti:PHATR_54151"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_1"/>
    <dbReference type="InParanoid" id="B5Y4D9"/>
    <dbReference type="OMA" id="EGEICCY"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05907">
        <property type="entry name" value="VL_LC_FACS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="702" mass="77232" checksum="A51C0C8872AC83F8" modified="2008-11-25" version="1">MTSLATTTTTRLLMRHAGKRSPWTRRTRMADVSTRRWMGSPETRALSSVSVTPLSTQPDVELSVRQREYYTQGWIGSDGLTAFETLHEMQTRSCQVFAEKRLFGTYSDASKAYEWISFAEFDQAVSVCRAVLRDLGVQEHDKVGLISNNRVEWVTIACAAYSLNANVVPMYEAQLPSDWTYILNDSGAKVVFCATTDIYDVVRSQVRINVPTLQANVCLDAPDGEPFAYSTLMHHATADVDGQFVKLPTPDDLANLIYTSGTTGKPKGVELTHENFCSNVKAGCRSLGDVRKLIKDDDVSLAFLPWAHSYGQTAELWSSMAHGSSMGISRGVSHILEDLQLVQPTVLFAVPTLFKKIYDGVHNAMEAAPPLRKKLMKAALSLGRERVAVNEGTRDALGFIERTKLGVLDKLVLGKIRARFGGKLRHAFVAGAACPPEVLSFMDDVGIQVCEGYGLTETSPIITINTPEYRKVGSVGKAIGGVTVHIVDEEGKELPIGEEGEICCTGPNIMRGYYGNAEATAEVITTAPDGKTRMFHTGDLGRMGEDGFLKVTGRLKELYKLENGKYVCPTPIEEGIGMSRFIAQVVLTGANQPFNVALVVPEWPAIRAELGLDDSVSDDELAMNEKVRALVDADIKIKCKNMKKFEVPQNWAFVAPFTAANDMLTPKMSIRRHKVISTYNDIIAAMYDSESIEKEEVQRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4S2</accession>
    <name>B5Y4S2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186060.1">
        <property type="nucleotide sequence ID" value="XM_002186024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4S2"/>
    <dbReference type="PaxDb" id="2850-Phatr33251"/>
    <dbReference type="GeneID" id="7204360"/>
    <dbReference type="KEGG" id="pti:PHATR_33251"/>
    <dbReference type="eggNOG" id="ENOG502RXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401627_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4S2"/>
    <dbReference type="OMA" id="GERMFIT"/>
    <dbReference type="OrthoDB" id="10263082at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838793" evidence="2">
        <location>
            <begin position="20"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="704" mass="77371" checksum="FB813CC847D2226B" modified="2008-11-25" version="1">MKFCSSTILILALGASADATNIRGVDLGRGLKSGNGKSNAERDMKNGWKNGKEGGKGKGSQAIPCCRRWFNFNKKASLLVQPLPSSQRRLMPRFLEHVRDGMSGDTDFPHGPLKAIATVGERSTCDDSLGEKIVGVPDGLGVYLVDDDMYELSSSQINDGAATFGGSHVQYVDYNRDAMTGFMTSDVPASSMVTGFGEMIEISYNLKGELVGPRVRDGNTTVGAHYANTDAAGAYVVVSEPAEADWLMQSLCSAHLEQTHQWDRFIGLEDDIFITNEEWMIYENGTLFVGIGAHAIDTHTKTDYSLGVFGQGGFEKIAEINSQHPDYTMFAVSGYNGDLTGNSAVLQARKDKYGMRPDGEEYVWSENVVPFRIFVADDFLARNDLRYGKLYGFAIDMSESGPSGGIFRDEFHQDPAKAKNGAKVDGKWISVDWTWDGEVRNFQHDVAWEFQLKPPGTSEGSSMEDYQWWNAGGLSSSGLKTEHVTPDPRTDTTGFVQGSTAGYFGHLYGELDITSQVKLGGKGEYADGRDATRNWDDADGEGKVTFKDIDGLEVVYSNDGKLYAIIQEDSGNDLGERMFITSPLEHEDDGEELTYYFIAMSGGSRNTRMTEGVGIPKGTNCEANAHEFSGIFDMSGLIRKQDGEYMLSASDEGHHKRKQDKKVNINDKTIIIGLQAHNMYCGVIEAFQADRGGQWLLYNPHIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5C9</accession>
    <name>B5Y5C9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATR_18693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186167.1">
        <property type="nucleotide sequence ID" value="XM_002186131.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y5C9"/>
    <dbReference type="PaxDb" id="2850-Phatr18693"/>
    <dbReference type="GeneID" id="7204038"/>
    <dbReference type="KEGG" id="pti:PHATR_18693"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y5C9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="55"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="381"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="811"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACI65637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1351" mass="146626" checksum="BC6B41EFE81B6970" modified="2008-11-25" version="1">MDHAVSGLASVYRELRTRSKTRQEQKNVDKADHGTESQSLTLTKALLLHQRRNLIVTGLLRLLNTSIQAFPAVLVSRLLKLIEAGDTHAPAKALQAAVTLVAVLSIKMLVENQYFHKVVKCSTQVRGSLAGLIFDKSLRLPGGGSGVTHKDGNGETSALGSGGVLNLMQSDASLIESAALQFHTTWDGPLQIAIYTYLLYQYLGSSVFWGISVLLATIPINSVTLRILNRLAKFENEAKDRRTKRTAESISNMKLLKLQGWEQRFADDIRIHRKEELSRHVSRGIVRAVNTAVSNAVPALVLVVTLTAYAKTGRPIVASTIFTAISLFNQLRFPLFFYPMLIDSLANGKNAMRRISTYLSSEEITPYVNFFPTVDGTGGSIEMTNGNFLWSSTRSIDGNTTSISPALSNVKLKVYPGEVVAVVGTVGSGKSALIRGLLGELNPSVGDGVLDRATVITHGNVAYCSQEAWLPKGTLRDAIVFGREYDKDRYRAAIYDAGLDKDIVNDASLADSTEGILSHDTDVGEGGSSLSGGQRARVALARALYAGDDTKVFLLDDCLSALDASVGSMVFERITARLRKTNAATVLVTNDPSLPRRCDRVYLMGKISSFGSCSTIVDNGSYDDLLSRGHNLRSISTVESNFGIDKKIDSQSGSRVHSDAGSAVDNMIAAQPTREERRTHVTGVLEEPTNATDIKQWRHADPECSIVGPGHFKDTSALADDERPLMSSSVTKLTSADDFMSAGAVPRSTYVAYFKSVRKPILVFAMIASYLMANGAQFYQQYTVAKWTELSHADAMAAALGAKYLRSLVNAAGVVSVFLWFRSVFTMQVGVRASDFFHSRMLSSVFSAPMSFFDATPSGQILSRFGKEIETVDRGVPDSIGSVLFCFLQIFMSIGALSAIITPGMLGPLGIVTYMYIKTMAKFRPAARDMKRAETKTRSPIYTQFGEALRGTETIRSIPGAKQTWSSKHRSLSDQNLGVFYTVKSFDRWLSTRLESLGNTVVFTAAVASVFLTRAGRMEAGSAGWGLTQALAITGLLTWAVRCLTDLETSMMSVMRVKELTDLDRDEVDVPGQTNVLLKDGWPWKGNVIFRNVSMKYNPSSPLVLRSVTVAIPAGTTLGVVGRTGSGKSSLLLTLFRLAEIESNGSIEIDGVDIRSVSLETLRSSLAIIPQDPVLFAGSISYNLDASGNAEPSEMWNALKAASPSLARQFMSTGGLESPISEGGKNLSLGQRQLICLARALLRQSKILVLDEATSSVDSKTDQDVQETIRREFVEKGVTVITVAHRLDTVLGYDKIAVLGAGRMLEYGAPNELLQKTSGELRRLVDADRLSKEKGSKQQASTNNKVPAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5M5</accession>
    <name>B5Y5M5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_44188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186211.1">
        <property type="nucleotide sequence ID" value="XM_002186175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5M5"/>
    <dbReference type="PaxDb" id="2850-Phatr44188"/>
    <dbReference type="GeneID" id="7203918"/>
    <dbReference type="KEGG" id="pti:PHATR_44188"/>
    <dbReference type="eggNOG" id="ENOG502TMMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800414_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5M5"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="39575" checksum="27DD2DF47F49F0DF" modified="2008-11-25" version="1">MSVVDVMQCDESSEDIRPFEWLTSPSSLGPRIREALEGSVKADGDGSRVLHVGCGSSALGEYLLENSTLYGISRVINVDKDVSTLRRMRSRWKKKNAGLDDCRLQYEQVDLLTEKIKCQSNTIDLVIDKSTLDCTLCSEETTASLLTEVYRLLKANGGVYLLVSFHNVGLLQPLLENCPGTDWDVSHSVMMRQVEDLTSRDTRCISPQKASRMESSTAWTESSCTPDEMYRKTVNVFFCRRRPSGDHTHELDRTSVSHHVNETSNKWYRDESPMLTEQRKMDLRNAFGDGTLDLESCYRMVFSEEERDHLDFEFFLDDWKSFCERGISVGSDHMDYATAVAFLEEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNT7</accession>
    <name>B7FNT7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177096.1">
        <property type="nucleotide sequence ID" value="XM_002177060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNT7"/>
    <dbReference type="FunCoup" id="B7FNT7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FNT7"/>
    <dbReference type="PaxDb" id="2850-Phatr42578"/>
    <dbReference type="GeneID" id="7196273"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42578"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1848981_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNT7"/>
    <dbReference type="OMA" id="WENDVID"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15443" checksum="AEFDAB904ACF1BE5" modified="2009-02-10" version="1">MNPRTEATAQTEPSSSIDASEMSAQQHGRDSTGGTATVRNPTGSVTMTVTDAATTRHEPEPLVLTLQAHPSVRWENDVIDNEGMGRKSSKRCCIFHKQRPFDESSTDSSDQDGNDDRDKRKIARPKKSKEVPDFQRYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPM4</accession>
    <name>B7FPM4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177237.1">
        <property type="nucleotide sequence ID" value="XM_002177201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPM4"/>
    <dbReference type="SMR" id="B7FPM4"/>
    <dbReference type="PaxDb" id="2850-Phatr42807"/>
    <dbReference type="GeneID" id="7196419"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42807"/>
    <dbReference type="eggNOG" id="ENOG502TMKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820058_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPM4"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="339" mass="38788" checksum="451CAB4949DE06DD" modified="2009-02-10" version="1">MATRRVFTANGPKILKTSIASQRVSQWYIRNSFFSTGNQRNDSKFDEWIPPEQPLSGDKGQSHLYVTPRMEQDDEDVDEEEALRRLEVALQKLDEEEARSKQEHHASDGTGAKGEETVDWLQTRRSVLGDDGFDMVKPSEAALKIQQASDIAVKEFTLFTKDEIAACLKALGGRDIIVVLDDPKKKRFGGAVIGMIIVTGTSTVQLRKLADALVRQLRRRKLQERGVVGAQLGAECSDDPNEGWVVVDCHNYIVHLQDERMRRALKLEALWTGRDRLYDLNIADEDEVDKYVAENPVPEGYERTVFDWDTRLRELQKNRWVSPNKPLVPKKRTRKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPS2</accession>
    <name>B7FPS2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dsCYC1</name>
        <name evidence="5" type="ORF">PHATRDRAFT_31942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176760.1">
        <property type="nucleotide sequence ID" value="XM_002176724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPS2"/>
    <dbReference type="STRING" id="556484.B7FPS2"/>
    <dbReference type="PaxDb" id="2850-Phatr31942"/>
    <dbReference type="GeneID" id="7196501"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31942"/>
    <dbReference type="eggNOG" id="KOG0655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067459_1_0_1"/>
    <dbReference type="InParanoid" id="B7FPS2"/>
    <dbReference type="OMA" id="HENARDE"/>
    <dbReference type="OrthoDB" id="39037at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37646" checksum="F8611C3B6E99F1D0" modified="2009-02-10" version="1">MVHSNDPLLSLRMKCAVGLSMNPHNHENARDEVSAMLDQERFYQCGDYLGRRNVRKNEKSGTSVRSVSEENEVLDGVCREKMCEWSYRVCEHFNTNREIVAIAMKFLDRFIDHCSCDRNAFKLAAMTTLYMATKLFNPKQIPIGSLADLSRGEFENSNIAEMELVILKTLDWRLNPPTVLSFINRFHSLLCIEEVSTAKDTHRRATFFAELSVYDYSLVTENASLLAIASLLNAFEGLEDPCFADVLHTNLNELVQCQLSLVVDVLAVEKVQSRLWYLYSCSAQVKADGIIPLRVCQERQQRHEAKIHPSGKDEALMDSPISVNLHERYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG6</accession>
    <name>B7FQG6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_9372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177399.1">
        <property type="nucleotide sequence ID" value="XM_002177363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG6"/>
    <dbReference type="STRING" id="556484.B7FQG6"/>
    <dbReference type="PaxDb" id="2850-Phatr9372"/>
    <dbReference type="GeneID" id="7196247"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9372"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_1_0_1"/>
    <dbReference type="InParanoid" id="B7FQG6"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF127">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="231"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="57321" checksum="3CF5110DC4EDB3B8" modified="2009-02-10" version="1" fragment="single">LHKTKLRLLRGRCYALVGQNGVGKTTLMNAINTGKIDDWPHHLVTAYVDSGSNVDPAFEAQIVLTYLIESTKRSKEDCVAKLKELDFTEEMLEGTIGALSGGWQMKMRLVRAVLIQPDIYLLDEPTNHLSESAVKWITDYLCNLEHPTVLIVSHDTTFLENVCTDVIHYEERAVWGPYRRLVHYKGRMSDFVKLQPQAKHYFELAATDNLKFEFPDPGRLEGVKTSTQKFLEMEHVDFRYATANKNTLTDINLKMSLSSRVVVLGANGAGKSTLIKMIVGETVPTNLGVCKFYVHQNLRVAYVAQHAFYHVEQHMEESPVAYIQWRFRDGYDKEKMESEAFKIPEEEQKAIDEFNLEGIWSRRLRAGVLEYEVKKKNIREKDNKYYSRDDLMAMGFEHLIKQTDEKIASKEAGLDLRPVTTSEIQKHLDGFGLPQEFGTYGKVRGLSGGQKVKLVLAAAFWTNPHLVVLDEPTNFLDREALGALSAALNEWGGAVLMISHNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQK5</accession>
    <name>B7FQK5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CSN5</name>
        <name evidence="15" type="ORF">PHATRDRAFT_43086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176887.1">
        <property type="nucleotide sequence ID" value="XM_002176851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQK5"/>
    <dbReference type="STRING" id="556484.B7FQK5"/>
    <dbReference type="PaxDb" id="2850-Phatr43086"/>
    <dbReference type="GeneID" id="7196869"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43086"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053034_0_1_1"/>
    <dbReference type="InParanoid" id="B7FQK5"/>
    <dbReference type="OMA" id="VEQNEMR"/>
    <dbReference type="OrthoDB" id="10266268at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="62"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC51350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="370" mass="40967" checksum="F085DE090B988BD6" modified="2009-02-10" version="1">MASKEGDDFQNAVQNDGMAEKKDTTLSSTPAADARYRFDADRLQTLQSAAPWMKDPRYFQKVTLSPSAIMKIMMHCQSGVQKGIAKGGNPIEVMGMLLGRPDPDTPRTLVITDAFPLPIEGFETRVIADDENVVNHMIALGESLERTRKEKFMGWYHSHPFDLGDHSHCFLSQTDLSTQLQWQRAEDPHGNPFVAIVVDPLRSHNLETPELKAFRAYPPEYVSPALNECPDGSVESSEQTRLEHWGSCWNRYYELSVEYYMSSTSRNVLQQLTQDYLWIRTLSRKSESSVTQRLCGCVKPFQSASLTAASVVSGGRGTGLGPGGSTSASVSSGIDAQTKEWQKAVSNLADIASEDMGEQALQSTKEQVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQU0</accession>
    <name>B7FQU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176927.1">
        <property type="nucleotide sequence ID" value="XM_002176891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQU0"/>
    <dbReference type="PaxDb" id="2850-Phatr32315"/>
    <dbReference type="GeneID" id="7196913"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32315"/>
    <dbReference type="eggNOG" id="ENOG502S29W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068166_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQU0"/>
    <dbReference type="OMA" id="FGCSKRH"/>
    <dbReference type="OrthoDB" id="36026at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855207" description="Methyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39577" checksum="B5639BBC0F451F3F" modified="2009-02-10" version="1">MSGLLIAALIFFIFGGSAQYDEHESAQLFALAVTSTVSSLRGSEEMSKNRNPLLSVEPLKYSLHPDWKLWSEMEGSEQQQALDRVGVYLKKYGDMIGHKKKIKKHGTCDLINIGLNIEGDHNLCGPAPPKPCNFISFGINDDPSFDRILADRWGCRGFAGDPTVEHPSKLHPLVTFHNVGATLLMNNEEREVDKGGAEDWWLVSMPKMRFFLGLKHIDIIKLDCEGCEVAFARDILREDPSYLHHVDQLSIETHVTRTWLDSREHVYYFGLHFALLEEAGFVLEWSNVFGCSKRHEVTGCMPELEQYGFPCGYKPWPAHPNVVIGVSCQDFLWKRYPEKASGSFSITKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQV8</accession>
    <name>B7FQV8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_9348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176936.1">
        <property type="nucleotide sequence ID" value="XM_002176900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQV8"/>
    <dbReference type="STRING" id="556484.B7FQV8"/>
    <dbReference type="PaxDb" id="2850-Phatr9348"/>
    <dbReference type="GeneID" id="7196922"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9348"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539145_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQV8"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="172" mass="19367" checksum="8C51C57961EC0A57" modified="2009-02-10" version="1" fragment="single">KRSDYISWDDYFMAMAFLTAQRSKDPNTQVGACIVDRHQRIVALGYNGFPAGASDDVLPWSRTAVQPLHRKYHYVCHAEVNAVLNKCSDNVKDTTLYVALFPCNECAKVLVQAGVKEVVYMSDIYHDTDSCRASRILFHMAGVKLRQYSPTCRLITVPLEGNKERGFLGDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR25</accession>
    <name>B7FR25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_2782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176972.1">
        <property type="nucleotide sequence ID" value="XM_002176936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR25"/>
    <dbReference type="PaxDb" id="2850-Phatr2782"/>
    <dbReference type="GeneID" id="7196589"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2782"/>
    <dbReference type="eggNOG" id="KOG2569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020277_4_0_1"/>
    <dbReference type="InParanoid" id="B7FR25"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="GOST_TM"/>
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    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
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    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="7">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="29608" checksum="FB6F1495F7EE847D" modified="2009-02-10" version="1" fragment="single">FLTAGEMKLPSIFFFFAISYAVCLVTWITNILAIRQGNAGHFGRNGQGANVYAIHYLMAVLLLFKTLAVLCESLRYHKIRRTGHAEVWSVFYSIFGFIKGVFLFTVILLIGSGWSFVKPCLTNKEKKLVAFLLTLQVVNQIALIVLSQRTEGENAFEKWTAVLHLVDILCCCAVLVPIVWQVNALEKSVTEDGENDSAILAKLKLFRAFYLLVVAYIYATRILVYLFATILDYHHLWVRYFVVELVTLVFYVVVGFIFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRG6</accession>
    <name>B7FRG6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002176505.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr31486"/>
    <dbReference type="GeneID" id="7196050"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31486"/>
    <dbReference type="HOGENOM" id="CLU_1242209_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRG6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="24233" checksum="9C2297F18D4CC786" modified="2009-02-10" version="1">MANEIAAAHTKHNRTAKGLVLERLLQGARGLDVGTQQASGVGGTFFKVTSNTGSSLDDSVFKRNFIQGRVKGLEITGKLSLRIKGLDRTRVAGSSGRGSQESGQGQHEKSFLRSMVGQRAERGWESRLWQGSFVALAMVPTGKSFPINLNIGGTSGAEEYIEPPLEGHAWGCFGYTEEEDLGDDCAEVFDIIVRARALLTCEESHRVSVVIVDRWAYLSCDKN</sequence>
</entry>
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    <accession>B7FRI7</accession>
    <name>B7FRI7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PHATRDRAFT_31508</name>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176553.1">
        <property type="nucleotide sequence ID" value="XM_002176517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRI7"/>
    <dbReference type="PaxDb" id="2850-Phatr31508"/>
    <dbReference type="GeneID" id="7196059"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31508"/>
    <dbReference type="HOGENOM" id="CLU_825040_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRI7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="343" mass="38342" checksum="AC99BD63B84238DD" modified="2009-02-10" version="1">MKRTKVPPVIRCRTPGADDTDDHDDPPAQQKPWKMLPPLRGTVSKRPNATGPPSPLATKVAREDCGDSVARVTILPGSLGIPVFGGRKYSVAPPSSPPPSLQRICSMVWTGPAQAGKTTLLRSFVQRKYYQASENSVRVQSDIDHEPWELDYFRKDYSFQTNVTIYLLPRMSISTRKSLPDSQRAILKKAEYVFLTVSSLDPDLDGTIRDWTTWLHWQISSSASLQSDNTPKMVLLLTQADLLPTRYTSPFSLIQLGSRVEQMFQSPHHAQLHSYHFCTATLGDTTWESVDDIVRHVLDEDTPRTAKLFMHTPERLLPEKTPVTPGDTIDTVDQTADDSSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRZ7</accession>
    <name>B7FRZ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ME1</name>
        <name evidence="10" type="ORF">PHATRDRAFT_56501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177890.1">
        <property type="nucleotide sequence ID" value="XM_002177854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRZ7"/>
    <dbReference type="STRING" id="556484.B7FRZ7"/>
    <dbReference type="PaxDb" id="2850-Phatr54082"/>
    <dbReference type="GeneID" id="7197107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56501"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="B7FRZ7"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="152"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="342"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71108" checksum="4275A7AC99540973" modified="2009-02-10" version="1">MISSACRGSLKSLCSVQLRSNTRQHASLISCNNSPNVKRFSTAFSSQTDGEVLTVGGALSGEEPIHETGEWAGCKRSFMIPIRISVRGTDILLDPLYNKGTAFKTGERDRLRFRGMLPHRIMNIHLQKERFLQALRAEDSNIRKNVMLEDLHDRNETLYHRVLVDHIEEMAPYIYTPTVGQACMEFATRYRRPRGMYFTEEDRGHMAAMVYNWPHRDVHVICVTDGSRILGLGDLGANGMGIPIGKLALYCAAGGIAPHRVLPVVFDAGTNNEALLQDKYYLGVQRKRLKGAAYFRMMDEFMDAVRFRWPNVLVQFEDFSSEVAQTLLDRYRDDHLCFNDDIQGTGATTLAGVLGALRAKGEEVTSLGDQRIVIAGAGSAGIGIAQVLMQAMEEQGRTPEEAKNAFYILDQNGLLGTDRANDLNAEQRVFVRSADNNLSLMDVVKKYKPTILLGVTTVGGLFTGDLIREMHSSCERPIIFPLSNPTNKAECTAEQAYEWTNGQCIFASGSPFDTIEFEDGRVFYPSQCNNMYVFPGLGLGASVCGAQKVTDRMLYVAAETLANFVSKKDMEEGRLFPQLTRIREVSHRIAVAVVEEALREGLATKVKPADANDLDSFVGRKMYFPEYVPLVEKREISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSC3</accession>
    <name>B7FSC3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177958.1">
        <property type="nucleotide sequence ID" value="XM_002177922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSC3"/>
    <dbReference type="STRING" id="556484.B7FSC3"/>
    <dbReference type="PaxDb" id="2850-Phatr43472"/>
    <dbReference type="GeneID" id="7197532"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43472"/>
    <dbReference type="eggNOG" id="ENOG502QZ18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1362721_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSC3"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855374" description="J domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="201" mass="22817" checksum="B6B0DCF8FE346C73" modified="2009-02-10" version="1">MAISFVLVLYVIIGSSLETDGFAPGFSTRRTLGSSREASWMNSSTRLPVRADKIDSKLLDDFRTSWGEFINPYEVLKVNRAAEQFEIKQSYYKLSRRYHPDGMRYRDILPGSCNNMEDVRNHWERIRMSYEILSDKKSRQRYDRHEALADPGQAVRRAASDAALKGVVGMGKGLLGAGSFAYHQIVKKKSDTVDGVEQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSG3</accession>
    <name>B7FSG3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177658.1">
        <property type="nucleotide sequence ID" value="XM_002177622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSG3"/>
    <dbReference type="STRING" id="556484.B7FSG3"/>
    <dbReference type="PaxDb" id="2850-Phatr32726"/>
    <dbReference type="GeneID" id="7197551"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32726"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807679_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSG3"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="344" mass="37754" checksum="ACE403DA2BCF64FA" modified="2009-02-10" version="1">MAGQKRARSQKQSQSSKSARKKVLNANDPRPVLDLWVPLPKDADSLPQTVMVWRLLDRLESTGFSHAALTHTVYGRPTPNTDDAESALPDSLWKDRPVTKGIKKANIKVLRRLHVVVENLVDLGRYNGPAIDGYDLVSISPRNDAAFSAACSSALAAQIITLDYTAGRGGNQLPFKIGAVDVRAAIERKAVFEIPYAPAILNRNQRKAIIQTCRELQVASLGVTPQVLVSSGPRTERNFDAGPMALRMPSDVVNLLRTVMHFDEQVSSQALTMGPNFALEQSKRYRFGKSLITDIHTEASYTDEDEKHLEILDQGNRKTKGTSSKIAEPDGDGDVVIEDGFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSG5</accession>
    <name>B7FSG5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177659.1">
        <property type="nucleotide sequence ID" value="XM_002177623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSG5"/>
    <dbReference type="PaxDb" id="2850-Phatr43507"/>
    <dbReference type="GeneID" id="7197198"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43507"/>
    <dbReference type="HOGENOM" id="CLU_701079_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSG5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="140"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="376" mass="43413" checksum="BAB68B683954222B" modified="2009-02-10" version="1">MDQFNMDEAETRTDEGGSSTHDVRATSPYQQAQHPINQAMELLSPDEKSSYIQAMERCPEIVATETDPQLFLSFESMRADVAARRLAMYWTYRERFFGTKRAFRPLVDLSIPPSRRALSFADVEELQHGALAKVPPDRHGRPILLVDRYRLRNADYEPDPNRWVRITFFWLTKMMHQPDVQRNGMVVVKIMRGQNLDRKRMVTSQMLMRDAMACRVNSIHLCCLPPKGGCKTFADTLVPIMFNFSQRLLGTKANIHVASSSESMLTQLEPHGFRKASVPTTLGGKWSYTKFDTLVTRLLSESFLMARNLPTDLKQSPLINDQHERLLMERVQRRKSGKRKIDATFISRDCWAKEQKFVKQPFAALASFYIHNKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSX6</accession>
    <name>B7FSX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_8518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177742.1">
        <property type="nucleotide sequence ID" value="XM_002177706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSX6"/>
    <dbReference type="FunCoup" id="B7FSX6">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSX6"/>
    <dbReference type="PaxDb" id="2850-Phatr8518"/>
    <dbReference type="GeneID" id="7197346"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8518"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1879464_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSX6"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC50556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="66" mass="7411" checksum="CBF8D61DCD69D3E0" modified="2009-02-10" version="1" fragment="single">KKRSPSDFLKSVLGRPVQVKLNSGIEYRGILACLDGYLNIAMEQTEEYVDGQLQAKYGDCFIRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT21</accession>
    <name>B7FT21_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_10089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177762.1">
        <property type="nucleotide sequence ID" value="XM_002177726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT21"/>
    <dbReference type="FunCoup" id="B7FT21">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FT21"/>
    <dbReference type="PaxDb" id="2850-Phatr10089"/>
    <dbReference type="GeneID" id="7197223"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10089"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_3_2_1"/>
    <dbReference type="InParanoid" id="B7FT21"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="141" mass="15570" checksum="64BBB0775D5DD8A2" modified="2009-02-10" version="1" fragment="single">EDEWRSWKTLGDPVLHIELREWADVLLLCPLSAHTLAKISHGLCDDVLSSIVRAWDWGYHATRPPKPILVAPAMNTAMWTHPLTAQQLQTVQSFYNASRYPEKGVLLIDPQTKELACGEVGNGALAAVETILSAVREALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT43</accession>
    <name>B7FT43_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178093.1">
        <property type="nucleotide sequence ID" value="XM_002178057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT43"/>
    <dbReference type="PaxDb" id="2850-Phatr43687"/>
    <dbReference type="GeneID" id="7196990"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43687"/>
    <dbReference type="HOGENOM" id="CLU_1036103_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT43"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="29786" checksum="57EBB8356E449B7C" modified="2009-02-10" version="1">MSLVHAAKIKEMDVEKQSLMKTKAVGPIKAAPRLLSNKTCRQRADTVQPPCSTTEEKPTAQESLFFPYQKNTHRCKTEIPTMIVAIAGGDRCVAKLDSSAHKVKLRDRNATRYGVYLGSKVWNRASRDLHDYRLVTRSCNSSLLGRPLQGPPPLWRPSAVPHDPFTVCTSRSLTQRAISPMSVTSDTSNDDISFAGKEVGLRGVSRVMKPRFGPKFTTQHPHFNGSKCMHHMLSTDERIFLEAAARLATYGKSNYFVEGRGAGSLVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTM9</accession>
    <name>B7FTM9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_10881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178444.1">
        <property type="nucleotide sequence ID" value="XM_002178408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTM9"/>
    <dbReference type="STRING" id="556484.B7FTM9"/>
    <dbReference type="PaxDb" id="2850-Phatr10881"/>
    <dbReference type="GeneID" id="7198012"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10881"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_1"/>
    <dbReference type="InParanoid" id="B7FTM9"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000016">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="434" mass="46995" checksum="F5FC5F909212C768" modified="2009-02-10" version="1" fragment="single">VVFAAALVFFMQAGFAMLCAGAVRAKNVQNTMLKNLLDACGAAIAFFTVGYAFAFGGTDFPTDTDTDTGNNQTTFIGTSNFFLVNVDDYSFWLFQYAFSAASATIVAGTLAERCQMAAYLGYSALLTGWVYPIVAHAVWNVHGFLSAHAVEPLWGVGMVDFAGSGVVHVTGGVTALFATIILGPRRGRFHDQDGQRLIRPRIFPGHSFALQMLGTLILWFGWYGFNIGAALLLDVPSSDNIAALAAVNTTLSGGTAGIVALFFNLWYLDKRTGEAYFDLKFAMNGCLCGLVAITGGCGVVEPWAAVVIGFVAGLLYNIGSRGLIYLRLDDAVDAIPVHLCNGSWGLVAVGLFASPSRLLVIYGHSDHPGWFYSLRDGESDFRLLASQLVGLIFIVFWVMFNMLPFFVWLNYRGWFRSDPLEELVGLDLSYHGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUN1</accession>
    <name>B7FUN1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_10865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178348.1">
        <property type="nucleotide sequence ID" value="XM_002178312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUN1"/>
    <dbReference type="STRING" id="556484.B7FUN1"/>
    <dbReference type="PaxDb" id="2850-Phatr10865"/>
    <dbReference type="GeneID" id="7198102"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10865"/>
    <dbReference type="eggNOG" id="KOG0614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_73_2_1"/>
    <dbReference type="InParanoid" id="B7FUN1"/>
    <dbReference type="OrthoDB" id="37858at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF143">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="36360" checksum="B1CCBF659A84FB46" modified="2009-02-10" version="1" fragment="single">LSLADLTKHTILGAGTFGQVWLVSRPGADGNDRAYALKVQSKYELSQSGQARSVVHEKEIMAGLNHPLVNRLLGAFKDVDYIYMLMNLVQGGELYGVMHTSTSDKLSENVSKFYIAGIAEGLGYMHSRGFVYRDLKPENVLISNEGYPVIIDFGFAKYVSDMTYTLCGTPLYLPPEVILNRGHNWGCDHWSLGVLLYEMILGYTPFYGMDQIELFRAIVKGKFSLPKWISAEANSLMSGLLTRDPRKRLGSLSGGENDIAKHPFFTDTDFGKIRRMEYPAPYVPSIKNPLDASNFESWTHVNDKLKTKYPKLTREEAKIFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUN4</accession>
    <name>B7FUN4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178350.1">
        <property type="nucleotide sequence ID" value="XM_002178314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUN4"/>
    <dbReference type="PaxDb" id="2850-Phatr44608"/>
    <dbReference type="GeneID" id="7197618"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44608"/>
    <dbReference type="HOGENOM" id="CLU_281254_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUN4"/>
    <dbReference type="OrthoDB" id="42195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="87"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125096" checksum="C126A48CF27E812E" modified="2009-02-10" version="1">MAELAHFQLSQALNVIAPEDKAAYLEAATKVPGLVQKESNFVSFFRCDRGDSDNACRRLIAYWQMRCEIFQERAFLPLNLLGNGALTSDEVDLLQQGSVVLLPADSAKRSVVFLDYSKCPEICKKNHNVWMRLIFYLLHLVSESEKAQSEGFIVLCRAINVTAADLPLESVLALSDLMLNSFHAQAKRIHVIVPPRTVTTNSFMSGVLKRLGSSLGGKVVFHLLDEETATRDQLHSYGLIKEGLPTCFGGTWSHELFERILLTRNHQDLVNEQLRVTAKRDAERTESFDVLKEVLNEKESLKSSGENLKFLSKEGTEFVTILKDLNEAMTLLPESLIKVYKRALKDCPEVVERESHPLTFLRFEYWDPWAAASRLATYWMERFEFFGKKAFLPMVGGAALQGSDLQVINRNSLLVLPNHKTGRSVLYMDRSRVPFDSKSTRPQKLRMLFACLTELSRNSMSQEEGFCLLARLCSEGPSGFDRYVLTRSLDLVRKAFPIRIAKAVFVNIAQQGVKRTLLKSFVPFWIKLLGPAIRDMAQFIFCETGPELLLTLESDGFKADAIPQDLGGSWTPEEHAVTKSSHVVSATEQFKMSARSRLEDAISIIPEDKKAAYLEAKARCSHLVQTESNSSYFLRREAYDVWAAAKRLVAYWDERKKIFGERAFRPMILTGEGALSLLDIEVFKTGYLVLLPADYNGRAVICYDPSRLSSDCRETRLRCLFYVMTIACEYEKTFEEGFIGMAIINKSGFQRTLGLHGPQDLVSRALPVKLAGSHVVHCPRQIRKEWFLERMLPVLMRLVSKATTRVVAHAGGSREEQLHGILAVGLEKEGLPTTIGGTWSYDSDFPQWIADRVQSERVRYNLIPAQSLTTANAPEDREETRKRKMGAIYSRRKRARQREKLDSLHTKSYDLSSRNDALRREGSRLEKLLERAKHEVGVYQGTSASSGATDIAIKNFTASRAASLFQTSFYPRNIVEQQAPSHVARDHTLLGHSVPTSLKEGSKRPPSMMSILQSKLGSSSAVGPFEMTYGHQSRSQMNPSLGSAFVGTPWAPATTTPSMRPTSNQQAVPYAAAMTSNMEGSTQNLDLGSLQGLPSSARIALAKYRQQSREDQGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV01</accession>
    <name>B7FV01_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_34196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178410.1">
        <property type="nucleotide sequence ID" value="XM_002178374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV01"/>
    <dbReference type="PaxDb" id="2850-Phatr34196"/>
    <dbReference type="GeneID" id="7197904"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34196"/>
    <dbReference type="HOGENOM" id="CLU_746943_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV01"/>
    <dbReference type="OMA" id="NGPRHAT"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="371" mass="41153" checksum="DF00B4F6CDEBDD49" modified="2009-02-10" version="1">MSPLKFQPVADSPPLSPETKRASKVTAITSTRTVTDIYLPSRSRTLSVNSQESNAGSRIEVTAKLLRSISSRNTTGTIVLKSTTGSAPRHHNRSSPKFDYPENVSELKGALQRRQNYIGKTHPSIGSLWNRIGNVHFRQGARHDAVFSYRNALVCDPGSHYGAAYANLGTVYGSLGSLDLAIVASHKALRNYKVDCGSEGKLANTDAIANVYHQLGLCQSLQGHYQLASSFLERSLEIRRSVNGPRHATVAKAFDKLGHVHALLGDYQISIQYHEKAGEIFLAVGFSLIPTLQKIAQLHVLRRNYTDAAIALRQIFSLQKGAGSDFDVQAAYGTLQRRRHMYTWTHQANLAEQCHKESMRFREKYGETEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV18</accession>
    <name>B7FV18_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">HAD1</name>
        <name evidence="21" type="ORF">PHATRDRAFT_41886</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 19">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179065.1">
        <property type="nucleotide sequence ID" value="XM_002179029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV18"/>
    <dbReference type="STRING" id="556484.B7FV18"/>
    <dbReference type="PaxDb" id="2850-Phatr41886"/>
    <dbReference type="GeneID" id="7199634"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41886"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="InParanoid" id="B7FV18"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106282">
        <property type="term" value="F:isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106283">
        <property type="term" value="F:ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="20">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEC49763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="256" mass="26999" checksum="D9B604FFDE179C3C" modified="2009-02-10" version="1">MATLARTVALVSGGASGLGAATARHLIQQGARVMVADLNMTDTLSSCYAQGPCLAFCPTNVTKSDEVNHALDQLERVFGEPLNVAVSCAGIAIAQKTLSKKGPHDLDDFIETMMVNTVGSFNVSRLAAARMQEREPDRDGLRGCIVNTASIAAFEGQIGQVAYSASKGGIVGMTLPMARELSRYGIRVMTIAPGLFETPLLSRLPESAREELGNSVPCPRRLGNPDEFGALVGTVLSNPMLNGSVIRLDGALRMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVV9</accession>
    <name>B7FVV9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178999.1">
        <property type="nucleotide sequence ID" value="XM_002178963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVV9"/>
    <dbReference type="PaxDb" id="2850-Phatr44848"/>
    <dbReference type="GeneID" id="7199565"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44848"/>
    <dbReference type="HOGENOM" id="CLU_291960_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVV9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119391" checksum="148DEDAA851C1455" modified="2009-02-10" version="1">MLVGDPVRCHSCSSSTFSGGTLSNSVRRFTFPYQSTTCQSRNDPDDVNSTAGVLPFPKERAFRSSWPTKLKTLPPKVKKRKTFAKRNISRTFRNRPRLFVQAEGLAAAADDASDDARIDEYAFVSPTYTAETEWENELESDLESAPSSARSSLCNLESVMSASSARTFFASNVTTPLGGLRESTIVEEPEHPEGPSDEESLVYTLPTKPPEEAGPLMPVKWRSKRTVSLRSIGVRPPVAYNTNNASQTLVRPTPSGTTVKPTVKTRFVAATDEASAVDPLTISDFSRLQLQVKLDRKQQKHASRLEKLEDRLQDKQGYKSLWNDYEKIQDDLSSVGTEASLGASSVHSFDLKKTDSWYFDFQDVEFAFESQEPDEGVSQASRSLLSEASMEAQVALFRRKRKERKNKKRAFASSSQSVEATPAPQNRREFSSSRSLDPEATPITRNTVQSDYGPVRRRRGLPVTDMEVSFSSDPKIVPGDAGSVVSDLEDESTWSLGDYKVSRRRTPGSGSSRQGSQQRFHLDATPSIYGISQDDTAYDKEAIQKRIDRLESALCSMNPPASNESIQTESQVVAPVQPTTGKILAVSPHDAPVVKLWPSESTELYTRQNLGSPVPHRQLMDRFDQVGDVTPRSANHMPTETTVKSSLPIKPSSEQVVFDSKDPHTGITESMEQVDLIQRNERSAPDKYTDATVTIKVAPATAKPKPSPEQANKLQRISACLSLEGPNNIITTKNTSVGPTCHGIRYAQSQEFCSSDKSNLCNQKVASAAILETLPFAVKVEQHVCQNEDKRDTDDTAYAKTSDATNVERLLALEETEDWMVDTGLLEEEAEGSKSLAMKKQKAFVVSREKPKLADPFLKRTNAFVISERTSMTEEDVRYNRWTRKSTSANDDFAKAGSAEQKASQCGRVECLEKRSDPVITELPNFTKVDDAKKASRDSLATCKANILATPEAMDTAPLMSDMYGNNAMTSNLSKHLSIDCQAKDFTPKTLFNPQIASMSTEEFLRISEDKMIGRASHREATEYSCTRTSVDEAGGTPDSSQSSTLKTSRSLVLADRVAHQVQEVLTKYRSLEVRRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW36</accession>
    <name>B7FW36_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_26565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178814.1">
        <property type="nucleotide sequence ID" value="XM_002178778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW36"/>
    <dbReference type="PaxDb" id="2850-Phatr26565"/>
    <dbReference type="GeneID" id="7199825"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26565"/>
    <dbReference type="eggNOG" id="ENOG502QW8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038878_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW36"/>
    <dbReference type="OMA" id="PYCYSEK"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF3">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="148"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="39285" checksum="5A6A780BEF31D06A" modified="2009-02-10" version="1">MAPSAESIEMVVEGYTSTDKNYSIISLYTFLEKRISEEQLQNIQSELEAVLQRYDARGTVLVACEGINGTISVPHCYQRDVLLELDNHFPTLRRRLSYHDEHVFFRLRVRVKPEIVTMGSLPSDMILDVANDVGAYVPPGPEWDALLLDPECAVIDTRNDYEIKIGTFHNAINPHTNSFTEFPAQLKIIIQERKPKKIAMFCTGGIRCEKATSYALQLIATDPDIPNIPVYHLEGGILAYLQIVPPLHSSFRGECYVFDRRTALSHGLNPSSCYQTCHVCRHPLTTEDRAGVTFQEGISCMYCAGDSSRNRDRHAERQRQLDLSKDKMHLQQQRGRPRSKNESITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWB8</accession>
    <name>B7FWB8_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179133.1">
        <property type="nucleotide sequence ID" value="XM_002179097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWB8"/>
    <dbReference type="PaxDb" id="2850-Phatr45057"/>
    <dbReference type="GeneID" id="7200073"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45057"/>
    <dbReference type="HOGENOM" id="CLU_415913_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWB8"/>
    <dbReference type="OrthoDB" id="10654937at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="660" mass="70487" checksum="DF5DC5C32B14F22C" modified="2009-02-10" version="1">MVVDRVVLWDGTNLLGHGAEEIMSALTDDLASATTSSSWTLHLVKPGRELPSKRVVLPDSKTILLPPVPTLGITFEESLDIRTRATTVSLIRLSDDSPLRGLARVGMVVATLNVSGGAVSHRGLSAMDLGQTLAATASEQGRTILLKSPQNNSLPKLSTTQLSLPSGAVSDWGIKFSDNAKQISAVVDVKDDSPLAPTMRPGQVILSVGLPNGIEYDDLPTDELYAVLHDSANAADQTRFWIVENRPAPLVDETFVTLPAGKLGVNFVGAPPRINKILPGSPLAGKVFIGQVVDTLVLPQTDEILYQLSAKELVGVLVETNEHTDRVARFINPDTRTLTAPPILPLPDYRALPLPASYPLGIGMTDLNGLVTITSVRKSSPLLKPGAGGEATLLGMAIDTVSFPNGQVLMQRTAAQFNDALKSTSDQEGRILLLKNPNSDTIAFSTLPDRLNIALPAGKLGITFGKTVPPMVERFTEDSPMSSIVPVGMFADMLTLSNGTILSGMTTHELVAELNASSAEIERHLLLKNPRNQNPTPAEVVLPDKAMVVLPTGTLGVSFRQTASGCVVSRVHEESQVYHLIRPGMAVDILTVKTGQVFTGLTAKECCRLLRASKETSGRKMILKNPETASMSQRNVVVSESGDLTSVNGDKVYDDESHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWJ7</accession>
    <name>B7FWJ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179394.1">
        <property type="nucleotide sequence ID" value="XM_002179358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWJ7"/>
    <dbReference type="PaxDb" id="2850-Phatr45127"/>
    <dbReference type="GeneID" id="7200319"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45127"/>
    <dbReference type="eggNOG" id="ENOG502SVI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815004_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWJ7"/>
    <dbReference type="OrthoDB" id="49444at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852716" description="Prolyl 4-hydroxylase alpha subunit domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37843" checksum="C6B57634D39909AC" modified="2009-02-10" version="1">MTKATPFFILCLAVASLKHAGTLAFQAGPGSSVAIQSSTVDVKRLIKHERKLSNGAQNSLIPLSAWPLILVSSQPLLTEDECSIISHYCQQNLSPSGTVEMEETFSRGAQILQRTQHFLDDILARPCGEAPVLPRYLTYTSSDAPIDSVEALLPDGLHVDTNNGFLFRYLTVLLYLTDCDSSATTFPLAKSITTVSKSVSNREREAELLLAAEELLDTNTHHTGFDERDTKCRQIDEAAWHVYKRNEASSFGFRVLPRQGYITAFFGIAADGSPDPRSWHGAEALEPGEKKDILTFFYEVPFTFSSKNEFARLVGERKQALLERHGLFQAGNIRNADESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWP0</accession>
    <name>B7FWP0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179414.1">
        <property type="nucleotide sequence ID" value="XM_002179378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWP0"/>
    <dbReference type="PaxDb" id="2850-Phatr45165"/>
    <dbReference type="GeneID" id="7200209"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45165"/>
    <dbReference type="InParanoid" id="B7FWP0"/>
    <dbReference type="OrthoDB" id="52713at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="43349" checksum="8A5BAE7F30A571A1" modified="2009-02-10" version="1">MVTTQHAREVYNVPLRKHFKSRFPALDVHRRNEPVATDTIWSDTPAVDNGAKFAQLFVGHRSLVTDVYPMKTDKEFVNTLEDHIRYRGAMDKLISDRAQVEISKKVTDITRAYNIDQWQSEPNHQHQNFAERRIATIEANTNNILNRTGAPDSTWLLCVTYVCCVFNHLAHESLDNRTPLEILSGSTPDISVLLQFHFWEPIYYRLEDATFPSDGTEQRGHFVGIADSVGDALTYKILTDGTNKILYRSSVRSATIPGETNLRLTPQDGERGPKPINFIKSRRTENQNSYAIKELPGFTPDDLIGRTFLTDTRDDGERLRARITRKILDPDKPSDINVSQGGNRGGIVSFMSALLYDPMYTWYDQSRPTSEATEIEPKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM5</accession>
    <name>B7FXM5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_12004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179582.1">
        <property type="nucleotide sequence ID" value="XM_002179546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM5"/>
    <dbReference type="FunCoup" id="B7FXM5">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXM5"/>
    <dbReference type="PaxDb" id="2850-Phatr12004"/>
    <dbReference type="GeneID" id="7200509"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12004"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXM5"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="96" mass="10364" checksum="E80F3511CC882B49" modified="2009-02-10" version="1" fragment="single">ARSLAPLGDRILVRRAAKEVQTAAGIYLPADKTKDPNEGEVVACGPGEKDVTGQLHPTTLKMGDTVLLPEYGGTKIKIDDEELVLFRESDILGKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXY0</accession>
    <name>B7FXY0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179842.1">
        <property type="nucleotide sequence ID" value="XM_002179806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXY0"/>
    <dbReference type="PaxDb" id="2850-Phatr45513"/>
    <dbReference type="GeneID" id="7200594"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45513"/>
    <dbReference type="eggNOG" id="ENOG502SM0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370278_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXY0"/>
    <dbReference type="OrthoDB" id="1427555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="717" mass="78618" checksum="9C560685EE41F4E0" modified="2009-02-10" version="1" fragment="single">MLWRKHGRSSLRLAFNTQQKQARCSSFSIFSASTFDGRYLPSLHLHSPNTRRTVQFIRPASAFAWNSNVEKQSVVKESQVQFDFFGEPVTFSGLTQSNTATSIKAMAAVDSFQLAVVTKGLTCYGGGEEAGLETQSIHAVAMSWTEALRFTTVWNQANTKQSAPMLAVISVAPVLAQAGTAYVKHLDTLLKNTKPVAPGFPIVQMYDTAQRAASAMNAIHLNDRERLHLRALAYLLKDEHATALAVLLRLLRTCPGDVLALSLAMDIAHTIGDKKAASRASGSVAAYWHERRGGLIRPSLPGHSIAESLIALGFAVNGRHEEAELMATQAMKRGRKVCGGLATWVQAYVFDAGGRTAEGISALANGDGIANYEGCGLLFFESHLGGYGARFALDREERGRGKSQALRLYEANFERVLHYSGFGEGRPWKTPQQKAPLGWIKQTPIGSGDDSASKDKGSFLQNLFSATNKNANEEEYEIILKGENSPSRKVEGWEPTCEDVLTWIPPTPKLLSDATLLLWRFTLNGTMSAKNGRWENMRNAWIALIDIERKHRDSPPLQFCPIASLASSMLVDPADTGAEYVGNGRLARGLYKMGTLLKLGRTTDGPVESTAIREPIAERDPEFWLPVNSELQKEWKDVVDSLTSALDGYIYPSDEEDSLANVMDTNNRLEAWDFEARPILEHAIVYASCKAGDIESLSVARSICSQGVTLRASSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZB4</accession>
    <name>B7FZB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_35809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180122.1">
        <property type="nucleotide sequence ID" value="XM_002180086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZB4"/>
    <dbReference type="PaxDb" id="2850-Phatr35809"/>
    <dbReference type="GeneID" id="7201032"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35809"/>
    <dbReference type="eggNOG" id="ENOG502S7GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798027_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZB4"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39685" checksum="AD612E6BD0C5F0F3" modified="2009-02-10" version="1">MREDAFGIFRYRYHYTTTYGLMSSDSEERDGFQQIQEQQQQQQHPPLHMRITRRTSITPINEPIEYTSFVCGLLAGVAQAGIFNPYDRALYLSVTNHRPFLAWENWRSPYTGFFQSIGGRALSGGLYFPLEHLFLRILGQHQPTRRCQRSDMDPKYNLLAGTAAGLANAVVLNPVSAIKYKTWGREVNQGMLKEAFGMVKKSGSLRPFGNGLVPTIYRDVVFGACYTWLRLQIQYSFQLYPHEQWKGNLTAAALATVLSGPFNYVRNIQYATSSRDRADGTLQVLRSLAHETGEQPTVARQLYYLQNRLRIGWGTARVACGITFAHGVYDWLHENLHESVQRLSLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZM8</accession>
    <name>B7FZM8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5060 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179975.1">
        <property type="nucleotide sequence ID" value="XM_002179939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZM8"/>
    <dbReference type="STRING" id="556484.B7FZM8"/>
    <dbReference type="PaxDb" id="2850-Phatr35518"/>
    <dbReference type="GeneID" id="7200771"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35518"/>
    <dbReference type="HOGENOM" id="CLU_014102_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZM8"/>
    <dbReference type="OrthoDB" id="1948at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032260">
        <property type="entry name" value="DUF5060"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16586">
        <property type="entry name" value="DUF5060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5060" evidence="2">
        <location>
            <begin position="305"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="982" mass="106026" checksum="C7E9FD5CE8EEB741" modified="2009-02-10" version="1">MSTGVTRGDQATGISLPAVLRYRTVQYVMRCSLFPSGHPTIPSGLSLGLARVWMLLVSLLCASLVVPAQSQSARITGFSLLNADTHQVIQPLRNGDDIDLFRAGTTLLSIRAEVSGSLEGGSVQMILNGRVRNSRRRQQQQQQHNAQYESIPELAQWGGHSVQARIMEFPDGTGNVQDSRSIGFAIRNSDPNAPTAAPVTPEPTTPWTGESISPSTGDGDDFATAAPTASNVQTPPTTPTSTVASPFPTAPPVPVRPLEPTDVHAYPASVRGTLSGTLEPWSKLTLCFLATTTDDTSATATTTSAFTHERNETVNPFTDIRLDVTFTALEEPVELVVPGYYAADGHAAHTHATAGAVWCVHATLPSEGSWMWRANFWHGANVALFDVNHGGVVKTPLFPVHGSTGQFILTPTTANGDDEDDLATGRAVTNATTPRRTRGRLQYVGEHAYKYPSGNDWWLSFGAASPSNGLAYDRFDGTTNAGERRKSWTPHADDYVSGNPTWAGGQGRELVGALNYLASQSLNLVTFSTLTLGGPDGNVFPFVSPQPSDRFRMDVSKLAQWEVVFQHADELGLLLNLRLESESAADVLDGKAGVLGLRRRLYYREMIARFGHHLSLIWNLGTATATASFSTANQQSLTNYIRSVDPYEHPVVLQTPSNQQAEVYEALLSSSNVAVEGTSLASDLYDTFNDTLIWRSLSAEQGHKWVVTSEYQGSQGATADRDDPTHDEFRVEVLWGNLLAGGTGVAYHFGDERGDSSGCSDLACQDWRSREALWGQSRYALEFFRENSIPFWNMGNSNERCTDGNRCFSNDEFVVVQVLRTDTPSLVDLTTPSPVVATYSLKWFDPLLGGPLQDGSVASVFSGPAQDLGTPPTSTGQEWIALLTRNRLPPTTAPTISLAPTQSPLLVVVPPTHAPHVPGTPTGTPIEMPSFRESDFLSRTIEPTSGPPSEGVSSAVAPTANISAVIQWILLFLILGLVRVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZW7</accession>
    <name>B7FZW7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180573.1">
        <property type="nucleotide sequence ID" value="XM_002180537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZW7"/>
    <dbReference type="STRING" id="556484.B7FZW7"/>
    <dbReference type="PaxDb" id="2850-Phatr768"/>
    <dbReference type="GeneID" id="7201306"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_768"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_1_1_1"/>
    <dbReference type="InParanoid" id="B7FZW7"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69401" checksum="13771B3C8944B6B4" modified="2009-02-10" version="1" fragment="single">QGQDSYFGGEPPLSEGVGYLVVLGFGALFSVITTALVWRQRRCYLGALQVRRLNLTAGRSVKTGLTASVIVSQWTWVTLLQSSNVAWAYGVSGPFWYASGATIQVLLFGVLAINLKKVAPSAHTVAEIVNARWGKTAHLTFLFFCFAANIIVTSILLLGGAATVEALTGMDFRLASFLIPWGVLLYTASGGLQATFLASYIHTVIIYAVLITMIFLVYIKFYSSDQIYDFLDQTVSFTTEECEAIFSDDSGTFFEAGKYACGPVSGNEKGSYLTMISGDGLMFGIINIVGNFGTVFVDQSYWQSAIAAKPSSATRGYLLGGVCWFAIPFSLATSLGLASTALMLPITSTEAGNGLVPPAVAFELLGDAGAILILIMLFMAIVSTGSAESIAVSSLVAYDIYRQYINPEATGDQILFVSRVVIVVFGVFMGGFAILLFEIGLTLGWVYLFMGVVIGSAVVPLWNMMTWKKASGPGAVIAAWSGLALALTGWLVAAKVQSGTISVEALGTNQVMLSGNLIAIFSSGIIHYLYSTFVDPQDYDFAELDTHITLVEEDYRGLTEEEKDPVLLRRAERWITRRGYALTLFLIFLWPLLSIPAGVFTKSYFAFWVLIAIAWGFGAAIVITILPLTESAEDINMVLSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZX2</accession>
    <name>B7FZX2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180378.1">
        <property type="nucleotide sequence ID" value="XM_002180342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZX2"/>
    <dbReference type="PaxDb" id="2850-Phatr46061"/>
    <dbReference type="GeneID" id="7201309"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46061"/>
    <dbReference type="eggNOG" id="ENOG502SPRI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1043779_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZX2"/>
    <dbReference type="OMA" id="FLWFSTC"/>
    <dbReference type="OrthoDB" id="46627at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="29766" checksum="7BB93FA391ADB1E9" modified="2009-02-10" version="1">MASFRLLPHGVYSLIPTVLTSMAWLASIFQDNCGFARLSGDIVADMTSSTEVPWLEVGFTAFREPRHNMQTNQWEVVYTGTCLPYPDVVEIDLIWKTSKAFAFLALVLGGGGTFFLWFSTCCVFSRGTWRWAGYEVLFASFFQALAYIWFRTAMCTSNQCDMSNGSNADIVATLLWFMAAVVIFARYPKPAEPIENDGVMMDPDSVALPSMTVQSSESLAQGTVTTADFQSEASMEEVELESRDVQVSGQDSRQERRSKSMEEAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G014</accession>
    <name>B7G014_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180600.1">
        <property type="nucleotide sequence ID" value="XM_002180564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G014"/>
    <dbReference type="PaxDb" id="2850-Phatr46090"/>
    <dbReference type="GeneID" id="7201333"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46090"/>
    <dbReference type="eggNOG" id="ENOG502SB6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_988537_0_0_1"/>
    <dbReference type="InParanoid" id="B7G014"/>
    <dbReference type="OrthoDB" id="46406at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="31712" checksum="F1DD9217A1E76B1C" modified="2009-02-10" version="1">MTGTWHHPYRGVGILVWLVLAVVLIVPGLVAAWIRPTIASSTRTVPRTFRLAPTPSTSRTLRRATHHEHNPDADRTIWDDNNNSNNAPDSIPIRECRHAELGSVADIILSSFYANTTGPWKQLYRLGELNRVQQGFPYGDDRARHRMLVALAPTNGDLVGFCDVDARTPNRPTSYTYNPRPYLSDLCIHPDWRRRGIARALVRACEQFCVDQLGSHEIFIRVERSNTPAVAMYQSLAYREIDNPDDPDGCIMLLRKELGTDEATSNTTMTVTGTVGTHTRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0E1</accession>
    <name>B7G0E1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180458.1">
        <property type="nucleotide sequence ID" value="XM_002180422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0E1"/>
    <dbReference type="STRING" id="556484.B7G0E1"/>
    <dbReference type="PaxDb" id="2850-Phatr36103"/>
    <dbReference type="GeneID" id="7201171"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36103"/>
    <dbReference type="eggNOG" id="ENOG502QXE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_938333_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0E1"/>
    <dbReference type="OMA" id="FLFTWPD"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="113"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="297" mass="33087" checksum="76C3C671E5496176" modified="2009-02-10" version="1">MRKIYLIASVLATFSHGFQIVPSRSLHSPLSYRRTERHFFNFGQKPQPKQAEPEPSKITTPEEEPDAVEKLFTFFFGKPEEEPFGLKRFGRERFPEQYPATVDDFDVASVEADDKEMAALRPLLKNTNLEERAVYLTYSANNNGWSAEAFHNAVDRKGGALVVCTTTSGQVCGGYNPKGWVGYGEARGSIAAFLFVRNKDGTFTKLRKVGGAGLAQIDNPESGPSFGVDSLVIPLNRDNKKLARSKLGSYYERFEDGTNSLFVSQAAVQLRDLKVYHGVYKDGEFIPFSDAEPFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0F8</accession>
    <name>B7G0F8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_46206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180671.1">
        <property type="nucleotide sequence ID" value="XM_002180635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0F8"/>
    <dbReference type="STRING" id="556484.B7G0F8"/>
    <dbReference type="PaxDb" id="2850-Phatr12713"/>
    <dbReference type="GeneID" id="7201279"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46206"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_1"/>
    <dbReference type="InParanoid" id="B7G0F8"/>
    <dbReference type="OMA" id="TIECKEF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="55"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="213" mass="23138" checksum="F44657B91F6A8B55" modified="2009-02-10" version="1">MLRQVIFGSFLALFASSIAAFSLDRRAFVRDVALTTAAVATGVTVSAPLPAFAVPVTGAKAPFFELPNSRGSGSTSLKNLINSGKWTVLYFYPGAFSKGCTLEARGFQRDIERYRALNAQIVGVSVDPVEKNAQFCSAEGLDFYMLSDTGGRVSNLYGSALSVPGFGMFSNRQTYIIDPEGNLRWVFTDVESRIARHSVEVLEKLNELETVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0N0</accession>
    <name>B7G0N0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180706.1">
        <property type="nucleotide sequence ID" value="XM_002180670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0N0"/>
    <dbReference type="PaxDb" id="2850-Phatr46270"/>
    <dbReference type="GeneID" id="7201471"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46270"/>
    <dbReference type="eggNOG" id="ENOG502S2WJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311129_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0N0"/>
    <dbReference type="OrthoDB" id="1295045at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd08877">
        <property type="entry name" value="START_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560">
        <property type="entry name" value="POLYKETIDE CYCLASE/DEHYDRASE/LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42300" checksum="37D7AC9F75E00662" modified="2009-02-10" version="1" fragment="single">MSPTPHHSRFNIRPPCTTGDSGDPGPSLGKDAERVFDFIEDERHLTAHDLLKDVRRRIKEQEAIVTRNSTRSSKRKPSRLAIIIRKESAKLETEQLDREELDRAKEILNSNKAAIDKLENRVRIFRKALHNLNEDDEWTYASTHFGIKTFYRREEDQSLSVKLEGEIEGVPLFEQICVLKEVDLHYKWAPFCSSSMTVADLDKLDTVGWFMIGLPHFGVARDGCFRAIGCDNIIEDGSILLVGQGVHDRPPDAPPPEDPFLSEDPILNDLGIPPVPKRRGSGRMTIRKFESVIHVLSPTSAKTRIVANIDPNMAFLPQSLLEFLMKHLAGVMLAKLQAATKKVLKNPVSNEHARKMREHEDFYKHWLMQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G117</accession>
    <name>B7G117_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-acetylhomoserine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180772.1">
        <property type="nucleotide sequence ID" value="XM_002180736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G117"/>
    <dbReference type="SMR" id="B7G117"/>
    <dbReference type="STRING" id="556484.B7G117"/>
    <dbReference type="PaxDb" id="2850-Phatr50964"/>
    <dbReference type="GeneID" id="7201765"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50964"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="InParanoid" id="B7G117"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="443" mass="47834" checksum="CF24513A553EF431" modified="2009-02-10" version="1">MQGGFDTIALHGGHDPDPSIPYGLGYGAPRGVPLYRSTPFVFRDTEHARKLFALEELGNIYSRLMNPTNHILESRYAQLEGGHPLSGLSVSSGTTAVFYAIANLASAGDNIVASSALYGGTYTMFNDILPTLGIEVRFVDGQDPKDFAKVADDKTRAFFCESVSNPSLTVFDLEAISKEAHNLGLPLICDSTFSTPYLCRPFEYGADIIVSSLTKWVGGHGACVGGMIVDKGGFNWGGGKHPVYDIPDTSYGGEAGLRWGHDLPDELQPLAYKLRALTVPLRNLGGCLAPDNAWMIVQGIETLSLRMERHCENAMKVAEYLSDHPKVEWVRYPGLPGDSQYEKAQKYLKGKGGAMVVFGIKASDGRLAGTQFIDTLKLHSHVANVGDARSLAIHPASTTHSQLKMAQQIAAGVPPEMVRLSTGLESIEDIIADLEQALDKVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1M8</accession>
    <name>B7G1M8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_46559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181058.1">
        <property type="nucleotide sequence ID" value="XM_002181022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1M8"/>
    <dbReference type="STRING" id="556484.B7G1M8"/>
    <dbReference type="PaxDb" id="2850-Phatr46559"/>
    <dbReference type="GeneID" id="7201699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46559"/>
    <dbReference type="eggNOG" id="ENOG502QSGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007113_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1M8"/>
    <dbReference type="OrthoDB" id="39300at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852903" description="G8 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="10">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CEMIP beta-helix" evidence="11">
        <location>
            <begin position="302"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC47710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111245" checksum="2D90B899F103F93E" modified="2009-02-10" version="1">MKVAYIGCLLLALFADEGEGASVRGSKDDVVAVEAPPRVRHSSSTALVSVPQRRLAEDAFEPLTCNSSFSSCIPWTSRWGRSAVKTTLIVIPCGQCIVMNLDSPKLTLQEGIDIRGKLVFPDRYELTVETPEVVVQGELEMRSSKLVDGSPAIKFVLYGNGDRHFDPVNNNRNACGGSSCNGGARPITVAGGKVNLNGLPTNTPTWLHVYDVIGSSAIVVSNSVRNKWGAGATIVITSEHQGYFGEQVRKITSISNVGSNSVRLNLDQPINRPVTLRDSPDFATEVALLSRNIVFEGAPGTKGGHFWIMHTPRVRQRIEGVELVNFGQEGLLGRYPIHFHMCGDVSGSVVVKNTIRNSNQRCVVVHGTNNLLVQENVAYFTKGHCYMLEDGIETGNQFIRNIGIRTIKAKVTIPNMGSNGRESDRSASTFWITNADNSWIGNVVAGSEALGFWFELLVRGNLANEHQDFDPMMVPTRKFEDNVVHSVFGVGMTYYLSGYIPETLQYFKNNKFFRNHHLALRIHRTRNIVLTGNKFSDNRYAIQIDRDEEIHVTDTTIVGYSDLFKDVVRRNRFAQAPCAQGISFQSTNPWKDKMDSELNGVILDKVRFSGFSNAVCSSSTAIELDSRLDGYKSFEMFSQYSGATVSDANSIDFCRGKSAGARDVYVSDTTGSLLDGVASAPSTLMVNSPELASFVNPSACTENAARCYTYCSNTCFRTVHYYVPVGQSRDYKLKVCDRKDASDCTVLSGYVHFNHPWPRRFAVHVPSGREYDTYFLDKGVPVYPTNVEIVFQEKLCPTAPDDDDIALLYKARGTTFPPTPSPTTALAACGNLIANSDFERGYNGYWDAQGAGTLSTTAGYKSATAMYYASGNRNRYWVGPSHQWREGLDLKCLKQGTTWEFSARLKLVDSTTGRGASCNTGSSSEGEMCPQVQLIVRDQSWTQHSFRISGFDGGDTWVANGFNEFKGYWTIPANGSGWRGGVANMRVILSEFPLGMDLVVDDFELTQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1Q0</accession>
    <name>B7G1Q0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the janus family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181071.1">
        <property type="nucleotide sequence ID" value="XM_002181035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1Q0"/>
    <dbReference type="STRING" id="556484.B7G1Q0"/>
    <dbReference type="PaxDb" id="2850-Phatr46577"/>
    <dbReference type="GeneID" id="7201712"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46577"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G1Q0"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF52">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852862" description="Pseudouridine synthase RsuA/RluA-like domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="6">
        <location>
            <begin position="189"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="607" mass="67187" checksum="4B0DC2F2CF0F00B1" modified="2009-02-10" version="1">MLSRLWVGLMFTTTVLARPTTAWATFGWRRIVVRRQVPIPAVTPTCFSSAIANPTDEWKGSSHSSSGFVDHILLDAAQAPLSVTDAVQRILTDRKKQNLAVTELNATELLHLGSVWFLPANAPRDPALGGKPVRLDQTAPALQAGDYLRVHHHPRRFPHAHRYDWSKSIHDTSGDKPGVIVAEDTDKGWLVIRKPSMVPVHMTVDNCRENVADCLKQARAWQSPTADARDVYITTPQRLDQNTSGLVVVATHKPFAAYFASLLRSKTARQLSGDGDDRNHESLGSVHKLYRCLPSIRAPKRFVEHPPDDTQWPECLLKIVKVGNVCELVGSPAGQDLAEALWQDASGQAKRIPPQAKAVVEVEIELLTGRTHQIRGQLSTLGFPLVGDAQYGGAVPRNPTNEQFYIGTEQLALQCCELAFRDPDREGDILVRSQRWNRFRLESAWWSAFLELFHSTLDATPAILDPPEESTESSSRISETRQEARPDLLPPRVSLSPGKNKYVLIRATHPNDKVVQCFVVSAAPSECGGPYHGNVAQDPREWIEAAGYTVEVTGGGRIDYQPESSTAKVYGFSYGFGKGDHIVAARLIQEVLGKSLRVTYDLSDDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1Q6</accession>
    <name>B7G1Q6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_36570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180896.1">
        <property type="nucleotide sequence ID" value="XM_002180860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1Q6"/>
    <dbReference type="STRING" id="556484.B7G1Q6"/>
    <dbReference type="PaxDb" id="2850-Phatr36570"/>
    <dbReference type="GeneID" id="7201716"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36570"/>
    <dbReference type="HOGENOM" id="CLU_579353_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1Q6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855720" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="73"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="472" mass="50256" checksum="5A272F5B195F1C82" modified="2009-02-10" version="1">MVSLSMKSIFSTVILLLASPVVVCVDSEKQQDPTETLQEFQARMASSIQGLLAQQNQTDALWFGISDPFYGRVYWTFGFANKGSSTPATANDHFQIGSISKSFGATVILLLAERGDLSLVDTIANLAPELTAQFPVYADFTVADLLGMQALVPDFLDDPTGLVRNLTADPTLRFSIPEMIQASLRSGQVEVCPQGEECAFYSTTNFLVLEYIAEKITDTPMPQLIADLITKPLDIGDTVEPKRDSDGVLPDPTVTPYAGSKCVEEFQQRGTTVDPGADLTELSRAVSSFGIGGNMYSTIRNLVVWAQSGTGDSLLANNTVTDRHVYRTIPSTDRSYGMGQYQLEGNWYGHEGGTFGFGSQAYRNDCFNAAYAAAVNTCAYTDILDQLRVLYQAELEGRITDTGGSPTMSPPERERGNGGGGGSGSGGGSIAVSPEASDLPTAAPVGGPSLGATLCYAACIAVNLVATVLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G225</accession>
    <name>B7G225_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181303.1">
        <property type="nucleotide sequence ID" value="XM_002181267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G225"/>
    <dbReference type="STRING" id="556484.B7G225"/>
    <dbReference type="PaxDb" id="2850-Phatr46990"/>
    <dbReference type="GeneID" id="7202228"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46990"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="B7G225"/>
    <dbReference type="OMA" id="MWEIDRV"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19094">
        <property type="entry name" value="AKR_Tas-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852865" description="NADP-dependent oxidoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="470" mass="52393" checksum="995F73746EDC5FD9" modified="2009-02-10" version="1">MKVAIAALLLVAAAECEAFPATTTMQMPTNRRNVLVASSFFGGMFGGSDEPAKAKLSGNLGTTNEVTKVVNGMKQRRLGGSDILVSELGLGTQRWVSTDYNAPDEKEVFEFMDKAILKNGVNLLDTAEQYPIPSDGKTSSDGDTERVIGKWMKERRVDRESVVIATKITGGRNITPRNIKLDCEGSLKRLGTDYIDVYQLHWPQRYSPQSNWGQSLAYNIENDSNLYWRGRGGPTSFEELCMSMEGLIQEGKIRGWGLCNDNAYGLTACTSTARSLGTTPPCSIQGDFSILDRKSEENGVAEAASPFNENVGFMSYNSLAGGMLTGKYMDIPAALDDLDNPERAKKNLQNPRGRMDTRGWGSTLYRYRSEAALEAIQEYARIAEKYKMPLTELSLRWCRQRSLITTTLVGHTSMKQLEESLKYFTIKEPLSKEVMWEIDVVHMRNRLPLFSNENVGRDWYGEGEIGEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G262</accession>
    <name>B7G262_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181154.1">
        <property type="nucleotide sequence ID" value="XM_002181118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G262"/>
    <dbReference type="PaxDb" id="2850-Phatr47015"/>
    <dbReference type="GeneID" id="7202109"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47015"/>
    <dbReference type="eggNOG" id="ENOG502SUVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722534_0_0_1"/>
    <dbReference type="InParanoid" id="B7G262"/>
    <dbReference type="OrthoDB" id="46660at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="383" mass="41569" checksum="3DD0C3F16D443CBD" modified="2009-02-10" version="1">MNDSSQKKSAGNFMVDVNLTMHDGGEETTRRVVGPSTVFSPAMTSVPASPFLAGPSSTPSTTLKTAPTTALVKAAAEPFVWDLSSAPTLPDLHPLERTAAFVPHVSSSEISRRISQILRERSIEACYEDDKAKVKCTTPDGVDFRIRLYRGRGEFHHGIIVEVQRRFGAAFSFHGDTYAILSAAEGKENQPCSSTSSTLPLVSDSDDESYSPNGVASLSTVSKMLVYRDHDSYLLALQTLAVITDAKNVGEKTAFAVSTELLQVESEVGSKIISLLVDRTVEDDIFKLRVMALTVIANAIQTVKGDISDMVREMLRPTLLQEMQGAHKNPRAAQMAARCVQFLLEGDHDVAEVHSVLQVALQAGQVRHAGLERQAQVCLDKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2C2</accession>
    <name>B7G2C2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181354.1">
        <property type="nucleotide sequence ID" value="XM_002181318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2C2"/>
    <dbReference type="STRING" id="556484.B7G2C2"/>
    <dbReference type="PaxDb" id="2850-Phatr13578"/>
    <dbReference type="GeneID" id="7202155"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13578"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G2C2"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="38880" checksum="7B7D1292EEAEB7A9" modified="2009-02-10" version="1" fragment="single">MDDPTGIAFTPALHVDEIGLTSEKYIPINETLTSLPLRISFDRSDMHHQATTSSTATAGGLSPARWRLLMHLSQAIEQQTQLGFEQSDIDDVRRLIAETNVTLLAITMLASALHLLFEFLTFKSEVNFWSKNEDLTGLSVRSLFLDMIGQTVILFFLIDKDSSLLMTIPSACGCLIALWKCQRAAGLQSQLASMARKEKEHSAAARKQDLTALTIESDRIATRTLGTVLLPFVVGYTLYSLVFEEHLGWYSWLITSASSAVYALGFVLMTPQLFLNWKLKSVAHLPWRVLVYKSLNTFIDDLFSFIIRMPTMARISCFRDDVVFFIYLYQRWLYPVDASRPAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2E4</accession>
    <name>B7G2E4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleavage and polyadenylation specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_28482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181194.1">
        <property type="nucleotide sequence ID" value="XM_002181158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2E4"/>
    <dbReference type="FunCoup" id="B7G2E4">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2E4"/>
    <dbReference type="PaxDb" id="2850-Phatr28482"/>
    <dbReference type="GeneID" id="7202166"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28482"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="InParanoid" id="B7G2E4"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="242"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67227" checksum="CC5E3637BD418F2B" modified="2009-02-10" version="1" fragment="single">MEDIMSITPLGSGQEVGRSCHLLEFRGMTILLDCGIHPGYDGLNGLPYLDRIEPDQVDVLLITHFHLDHVASLPYLTERTSFKGRIFMTHPTKAVTRLLLGDYLRLLQMKNAKPEDVLYTEADLQSCIDKIELMDFHTTVTVGGLSFYALNAGHVLGACMFFLSLGGRKILYTGDYSMEDDRHLMAAEIPAESPDVLIVEATYGVQVHASRAEREARFTGTIERVISRGGRCLIPVFALGRAQELLLILDEYWQANPHLQNIPIWYASKLASRALRVYQTYANMMNARIRSQMDVSNPFRFRFIQNLKSIDVNSFDDSGPSVVFASPGMLQSGVSRQLFDRWASDHKNGVLIAGYAVEHTLAKEIMAQPKEVVTLEGRRQPLNALVDYVSFSAHVDFVQNRSFINQVAPKHIILVHGQKDEMGRLKSALLLQYKQFPENKRPTITMPPNLQEVKLKFARRRSAKVMGSLADRQKEPKEGEEVRGILVTHNFHSKLVAPEDLATYTPLRVGSIASKLHVPFVGSLATLRLFLTEMFAGVSESTEESEDSTRTIFQLVNEVCKLSVKVTLGANKGVAIVEWMASPQGDILADAVVALLMHAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2G6</accession>
    <name>B7G2G6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_21369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181376.1">
        <property type="nucleotide sequence ID" value="XM_002181340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2G6"/>
    <dbReference type="STRING" id="556484.B7G2G6"/>
    <dbReference type="PaxDb" id="2850-Phatr21369"/>
    <dbReference type="GeneID" id="7202177"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21369"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G2G6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="308" mass="33280" checksum="D3F30CF5BD4F21E4" modified="2009-02-10" version="1">MHMSTAFTSGSKHRIAVAQLRSTSDKFSNLLDVARCAGWAKRDGAAMLFLPECCCFLGESASQTLEEADPPIQDADILILDGLRNIARESGLWISAGGIHVSGAPPHDTADPDHSRVYNTHLIIDCVGTVKCLYRKIHLFDVEIPGQVSLRESATTAPGKAVKVCDSPIGCLGVTICYDLRFPEMYVKLTTQGAQILLVPSAFTIPTGTAHWHTLLRARAIENQCFVIAAAQFGEHNHKRESYGHALIVDPWGEVLADAGGADGGGTVSIDASNLVTPSIMVQEIDLDLVTSARQRIPIQNHRRAAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2K4</accession>
    <name>B7G2K4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181397.1">
        <property type="nucleotide sequence ID" value="XM_002181361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2K4"/>
    <dbReference type="PaxDb" id="2850-Phatr37257"/>
    <dbReference type="GeneID" id="7202034"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37257"/>
    <dbReference type="eggNOG" id="ENOG502SG18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336662_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2K4"/>
    <dbReference type="OrthoDB" id="49671at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114801" checksum="3FEEAEAB3F685BDB" modified="2009-02-10" version="1">MNDLVRKVLFSSYPSSGPSLPCTSESLGVKANRRKKRAKDETSVLMALDPNRDKPSKRTPMHHSLRLKVHDTLATLGSPAVSRKPSITSEGEMLLSLSSLSLNRMAKERRGNVTSSGLLESSRDYEEVTKLKNHSFRGVPSCRTNNDASICKQYCVSTDPSLKKAKRKKPSDGTEKRLNHCSLGNFPAMSQAQKKGKPVPLEGGVLAFVDKTSRSKFFLLPHRYPRGSSKTNDDSTKILLKGLGTFVEESAEKGFASKKGKAHAHLEDGGKSSEIPLINGLVDFATENTISRRRNQKAARKNLPVQCDSSKPQYLRSLKPSRKAITNIHTPTPFSQSDQRKAATTIEATVFSDQHLLGIKIPSSDPLETISPIADSSPTWTQGRGLSDPHCVEVKDTAPDKVLRDTTIWPCSIKSPGVVENGNRRNHRIERLKVADKGTRFAEEKQDTGVMNKSLEAKRLNGKSSYNGRILQAERFDIPVLSNENSNPLSNREKIASSEINSRKEIVIGEVELDFAAAPKQNESVECISLASLNADEDTRDLASLGSATENYPRAESFHQRVMASGDFTCPCDQDAFIKSSSFRSQTDFDKQQSSPKGLQSRDIKNHISSDMDENYAPLSNGSPVRIERRSARCRVQTKRLGVFATPSELQGRMRKKRMLPSRASMSVSDSNNVEKSNGCGLSFAGPKQTVPEVKRERKGAGLTIPSRVCRLSRKNGPQKHLRVPIKDIESAGFISSSSAVHKEPHLAADNVELSASPSPGTLSRQNRKTSVNHVGETFEAQLVSLRPPGRPLEGSLRNKTTMQDFNDGWDETRVCLLQRAHRSAEPTSQTFWHDIADSVGLKTAHECREKFFSLHEPPVPIRERKSKAASMDNNFEDDLFQSTPLRPHLRKAHVVDDTRCSRYANLSGMDLGSAIKFNKRCAEGTDSGEDDLIARHVDIRPKAGYKSYVQNMRRAIVRSRKDKGKRMKQTKSQALKGSRAIQETVYDHEVDMNARLTPGGTLRLRNQNDVTEADDFWEVAYGDDSDQEVDSFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2V4</accession>
    <name>B7G2V4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_28568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181449.1">
        <property type="nucleotide sequence ID" value="XM_002181413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2V4"/>
    <dbReference type="FunCoup" id="B7G2V4">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2V4"/>
    <dbReference type="PaxDb" id="2850-Phatr28568"/>
    <dbReference type="GeneID" id="7201976"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28568"/>
    <dbReference type="eggNOG" id="KOG1002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G2V4"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="535"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="707" mass="79696" checksum="8949DBF7342300B3" modified="2009-02-10" version="1">MYHQETQKPEIRGGILADEMGMVRLHEMDMCNVPPKMRPHKYAAARAGTLVVCPVIALHQWKTEIEKFTELDTLSVGIYHGPNRATDMPPELMQKYDVVLTTYQVLEQDFRKMMSPNKISCPNCGGKFKVDKLRVHLKYFCGDGAERTEAQARQHRARDRDENGSGRGNTNRGIGGARGKKDKVKKPLTPTKKHLSTKTMVGSRFSVLHSFCWWRIILDEAHFIKSRSSQTAASAFSLSAIHRWCLSGTPLQNRVGELYSLIRFLRIDPMAHYFCKAKGCDCKSIHYRIKDGKCQDCSHHAFSHYAHFNRYVLNPIQRDGYSGDGRRAMFKLKNEVLDKSLLRRTKETRAEDMNLPPRLVTIRPIRLHPVEQDFYDALYMNTKASFNDYVDEGTLLNNYAHIFDLLTKMRQAVDHPYMIVHSKKNTEKRRLEQGAPVANGSVDCDICHESPTERVVSSCCGSGFCRECVVEYLTGAGGGSTPCPSCQSPFSIDLNQASTEAPVDDGTLAYGHVPSGSILRRINLAEFATSSKIEVLVQELVAMRKGRPGSKALVFSQFVNMLDLTRWRIHSDPCLADLGLGVRILHGGMDVKSRDATLQAFREDPSVRVLLMSLKAGGVALNLTVASEVYLLDNWWNPAAEMQAIDRTHRLGQYRPIRAVRFIAEGTVEERVLQLQEKKRLVFDGTVGRDAGSLKMLTVHDMKALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Y7</accession>
    <name>B7G2Y7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181695.1">
        <property type="nucleotide sequence ID" value="XM_002181659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Y7"/>
    <dbReference type="PaxDb" id="2850-Phatr47323"/>
    <dbReference type="GeneID" id="7202490"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47323"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383331_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Y7"/>
    <dbReference type="OMA" id="KRWPYLG"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="398"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="722" mass="82129" checksum="3A04B4720A8BB020" modified="2009-02-10" version="1">MDLSVLAAVGSFVVSERVLKPKATVLVILGAILAYDLTTKTHDVSSLRVYRGPALFAFTLMMCAYSLRTWRRNGIACDELLFLPGTAHGQRHGLDDANNVSMGHDSAPLRTVEAISHSPDEGDVAAGWTIPALELTRTNAATANSAGVVQRNSQSPVRSRTLSHESSISSIQEFVNSWDEDDTEHLDEDNRISTSTGAESEFFLSEEANSGSTTPSGNAPQTGIHQRGSRLTRGVERFRENHPQFTRLGSFFFFRSSATSTQSAEYAPSGPSVVGAALDLSMPILFNFHLYIEAYNHMDQYGSDFPAKILPLIFLSVLVVRSMFPPGRRMRFWSTMKFTATAPFHRSRFRDCFIGDVVTSLVRPCQDVLFALSYYVTVIWGTLSQTYGLSESGSYLERSWILHNVVLPSAALLPLWWKFLQTLRQSYDTGKRWPYLGNAFKYLSASVVILYGMTHREDRRSIWWLVCFAASMLYQIWWDTIMDWDLFVIETRSDQATDTDQVWFASLSSYRPNSYVLPFLESCTRPIRKTFVAIVTFIPSYKQIKLRPQRLYKSEAFYYKVFVYNTLFRFTWMLCYIPAYHLSASGEEQVTTFSSDTKTYVGVLLPLAEILRRALWGFLFLENETIKLQNGNASYSRIESVDEPDEENADQSEMSSMSDGSSKVRLPSWLGSPQLQDESSFRLRDRFRRFLECNERMRQRLFILELFLWAVAFVGLGLWATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G314</accession>
    <name>B7G314_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181709.1">
        <property type="nucleotide sequence ID" value="XM_002181673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G314"/>
    <dbReference type="FunCoup" id="B7G314">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G314"/>
    <dbReference type="PaxDb" id="2850-Phatr47345"/>
    <dbReference type="GeneID" id="7202504"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47345"/>
    <dbReference type="eggNOG" id="KOG4393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652947_0_0_1"/>
    <dbReference type="InParanoid" id="B7G314"/>
    <dbReference type="OMA" id="RFLYKMI"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855654" description="tRNA pseudouridine synthase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="295"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="421" mass="46762" checksum="8EE2BD08C537CA91" modified="2009-02-10" version="1">MVGHETTAWLLTLFGGACASLACPGITALALPPVAANPNFQRNAALRTVAWGADEVTPVAVNFTEQPLTSALLHVSYDGRQFYGWSSGNDPKDRESNAARPRYSTRSRRRRRNRGNYDGTVRSVQGEIQYCLSKVYGNIDPQRVVVEGCSRTDKGVHARGMMAQIYCLHETTSPNDDPVVDWSIPGKRQPHPRNATDTSYFTQLPMNLTKLAFTLNRMLPHDISIMGIAPTPHPHVTGCNPAISALPFHPTLSCRHKTYRYVVSVGTRADPTKRLYVWHLDRAISTFSLDQAEQACQILQGSHNFAAFQGAPRGSDNKIKFTMRNTTCQLISIRIQHQSTWLDTETYVVSVTGDRFLYKMIRFLVGTVVGVGTGKLTLDNVAAMLLTQSRNNLQVECAPPHALVLEHVEYDAAIDWQPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G374</accession>
    <name>B7G374_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-adaptin appendage C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AP4beta</name>
        <name evidence="8" type="ORF">PHATRDRAFT_54730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181569.1">
        <property type="nucleotide sequence ID" value="XM_002181533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G374"/>
    <dbReference type="FunCoup" id="B7G374">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G374"/>
    <dbReference type="PaxDb" id="2850-Phatr54730"/>
    <dbReference type="GeneID" id="7202532"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54730"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_5_1"/>
    <dbReference type="InParanoid" id="B7G374"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="7">
        <location>
            <begin position="684"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="805" mass="88032" checksum="5CFCFCCA16A157CE" modified="2009-02-10" version="1">MSTPYAGQAPPPPGGATATAGVPDSYFTESRKGEINELRTLLRAFATERDPQRKRDIIKKVIAYMTLGIDVSRLFSEMMMAIETRDLVIKKMVYLYLTNYARTHPDLAQMCTNTLQKDCGNEDPMVRGLALRALCGLNLPQMVEYISEPLRRALTDGHAYVRKTGVMGILKLYHLDPDGFHEANFVDILYDMLRDPDASVITNCIIVLNEVMQKSPNGGMAINRAIMLHLLNRIHEFNEFAKVQVLELVPRYIPANEDEGFQIMNLLDPVLRTSSSGAVVATVRAFLSLSDTLDDGSEAMKRQIVARVKAPLVTQISSGSSEIMYTLLKHVDTLTTICPGVFDDEYRQFYVRYNEPTHVKYLKVAILPRMANPDTAPDIVSELAEMVHDRNTKLSRAAVVSMGRIACSGNGGAGAAESIARRLVELMDSGTDHIASEAATALTLMVRKEPSIKTLVAPPLVRSLKYIAESSGKASTIILLGECGELVTEAPYALEKLIDTYDDIHDVNIKIALLTSTVRLFFMRPPEVQRMLGRLLAVATDDVSSQDLHDRALMYYRMLQSGADPHTLERVVRTSTVVAQGVSFAEEDDSELRKELMEEFNTLSIIYGKPSVNFIAPEFQVKYKKMPDEHPLAPGETGSFVAPPVAPVPAASIPVVSNDVDLLGFGDAEPMAAPAPMASNNLTLSASASMTGGEYQSQWGSVSDADATVSDVPLRALPSSTDEIENVLAAVNIMTMASGELPNEFKFFLYAKDSSSGATIMIQTNVDKSSPSDACMIATIKIGGPCLDPTGLAEQVIQIMRMQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E5</accession>
    <name>B7G3E5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181773.1">
        <property type="nucleotide sequence ID" value="XM_002181737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E5"/>
    <dbReference type="PaxDb" id="2850-Phatr47446"/>
    <dbReference type="GeneID" id="7202568"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47446"/>
    <dbReference type="eggNOG" id="ENOG502S7YF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740803_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3E5"/>
    <dbReference type="OMA" id="SQSWYES"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852886" description="J domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="341" mass="37449" checksum="A59D3AE528A41F6B" modified="2009-02-10" version="1">MRLTFLICLLATERGCGFSLRAAFRTSRDSLPSLTSAVSPRGTGMGMGANTKGGTKKKNGKVKQPSNPPYDVSASLLRLDKKYEELQLAAAKTLQKEFDSDDDLVTTEYIITARASPIVADWVPVAQLCLARTQADAHASEGAADPTLQAAVSLYCRELSHVAGMGSRLFQSVARNELQYAVESMDSFHKHVYEVVLEGKNENTKNENVMTKTEARSVLQLEVDVVDKSEIKRVYRKMSMAWHPDRFVGKDLTDEEMKEASVMYSKIKLAYETLESGIREIGKSWYESLGGRARTDFHGPVRLSPISEAKALLEASKVSSAVVGLDPEMVQGFVARSQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E8</accession>
    <name>B7G3E8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L9, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_47449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181605.1">
        <property type="nucleotide sequence ID" value="XM_002181569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E8"/>
    <dbReference type="PaxDb" id="2850-Phatr47449"/>
    <dbReference type="GeneID" id="7202570"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47449"/>
    <dbReference type="eggNOG" id="ENOG502QZ7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1177371_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3E8"/>
    <dbReference type="OMA" id="CGIALEM"/>
    <dbReference type="OrthoDB" id="45574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="entry name" value="Ribosomal protein L9, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_bL9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_bL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_bL9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="Ribosomal protein L9 C-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855681" description="50S ribosomal protein L9, chloroplastic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein L9" evidence="9">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL9 C-terminal" evidence="10">
        <location>
            <begin position="137"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="236" mass="25337" checksum="80417EFFD9CE052E" modified="2009-02-10" version="1">MKISSGSSALRAGYFLALWTLVRAKTLLNAAFVPAASPSAASRCQTQQDFLHRSPGEFSISLQAKKKNAPPTSSAKKIQVKLLKYVAGTGQAGEIIMVTPPFFNNKLRPTKSAVMITDEEVAKEQMESNEQQRQLLEQANRVKQTLEALTVQISRKAGPDGQLFGGVGPKLIMDELASKLGGEEFLGSKGVKIASITDPNGKKMRGDIKNTGEFEATVTLAKDVSAKLTVTVKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3I9</accession>
    <name>B7G3I9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181797.1">
        <property type="nucleotide sequence ID" value="XM_002181761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3I9"/>
    <dbReference type="PaxDb" id="2850-Phatr37711"/>
    <dbReference type="GeneID" id="7202271"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37711"/>
    <dbReference type="eggNOG" id="ENOG502SQJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617483_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3I9"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="359" mass="41354" checksum="ADBD64B6A7585A14" modified="2009-02-10" version="1">MYHFHRELNDTQVCDLINEKNYTIYEQPQDNDVICHWYFHERDQSGTQVMIASSESQNYLAVVFAGTDDLRTSLTDADILLTTFGDENFTLPDPRVRIHSGFNTAVFGQDVFREIVRKFDALRILRPQTRLFTTGHSLGASDSILTAVGLTLYYEKQAKLHDAHHEALPSYLRHPPPVITSLNFGCPRIGNSYWRDFVHMNPTVQRVNIWRVVLGWDLVPRLPKLIYHVGHTIQLYRNAYWESQADPENATAIAYYQHYGDVEEGLAGVPFGWANAPFIWVPGALLSHVARRYWEFLYAWTQSSPEHQATWVHSFVTIATDYDDDTRPPNVDDDFWVDPPDDELFEAADELDMVSTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3Z5</accession>
    <name>B7G3Z5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181826.1">
        <property type="nucleotide sequence ID" value="XM_002181790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3Z5"/>
    <dbReference type="STRING" id="556484.B7G3Z5"/>
    <dbReference type="PaxDb" id="2850-Phatr47526"/>
    <dbReference type="GeneID" id="7202769"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47526"/>
    <dbReference type="HOGENOM" id="CLU_459658_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3Z5"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="496"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="594" mass="64120" checksum="904DD76BDDC42C22" modified="2009-02-10" version="1">MAPVVAALSANGDLVAAALPSASPSSSSSALRVLVFQTATAQLQTTLATSSKKLADSSTSQHQVIRAITFGNQNTLVAALTENAQSHTALHRSGGGAVLVWDLTRGVLAYEIPTAQSVDQSILSIALYDSHLYVLLSLHSGTSKNKSNANSKLQIHQYDAVTGVLQRKIKAGKQGSAHGCSLAVTEGTLLVRQADVVRVLHRHTASKIAKLSVGSVGNDDVDDTNRSLVNSIAAARNVGATLAGDQMVLFHSLTGAKFVKQDLPSHADRTGLQVWDSTNTEADGKDSDEVAFVTDGVDIYRIRNSDDSSTGSSRVEKVTRLVVDANQDRNDTAVLGWQNQVIVVVANRQQKSNAASLQIRRHNLVDEIVIAWQTPEFDKDITMKDPSMSLAASKRKADMQTVLGPAQAGGEAKAIDGPIPKRTKMDEEEEEEEGGIEGPSVGERLRLLRQALEKEEESDDDDNDDDTEKSKISYPPKKATTESLTQLLTQALQSGDDSMLELALSVRDTNILQETCQQLADEHLPTLLNALTSRLASKPARAEFLCVWIRVVLLTGRIRSAGHLQPLRNLLQERIEVFPALLQLEGRLSMMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4M8</accession>
    <name>B7G4M8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182102.1">
        <property type="nucleotide sequence ID" value="XM_002182066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4M8"/>
    <dbReference type="PaxDb" id="2850-Phatr47715"/>
    <dbReference type="GeneID" id="7202897"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47715"/>
    <dbReference type="HOGENOM" id="CLU_1605917_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4M8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="166" mass="18704" checksum="511814F734219002" modified="2009-02-10" version="1">MTKTNRTPASTYASPWIPPRESVIHLHGSVRKFSHKTPIKGSCKRSKSSANESNSMRLFLAIFSCLILSVIARRGQPGKQAHGVGSPQTKQIFMQWGYPYGWGLTVPPSTDDRLSRPEDEVKAVKRVEKANESVPMKKRGWFRKNKGPGKEQPSHRFIQNALISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4X4</accession>
    <name>B7G4X4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carotenoid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_54800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182312.1">
        <property type="nucleotide sequence ID" value="XM_002182276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4X4"/>
    <dbReference type="STRING" id="556484.B7G4X4"/>
    <dbReference type="PaxDb" id="2850-Phatr54800"/>
    <dbReference type="GeneID" id="7202950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54800"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_1_0_1"/>
    <dbReference type="InParanoid" id="B7G4X4"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF3">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="923" mass="103052" checksum="7279B4021A319DA6" modified="2009-02-10" version="1">MTPVTQSPPVELSTDPPVALSLALPPLSPTADGTLQHHHLTTTDDESSSPWPVIRSVFRGQNNFSDPLNRGWNPWRPGISSRQDKCGVEYVKMHGQYFPTSGSGFSTGPVGQHDGHELEQRCDTERQGGGHVNKGNHVEANVATSVLCATECCLPHREPEPKTVCVVVLRSLQRDPTFQQDEVSAFLGAFRGWIGNEVDRLFEWAATAAKALCMANWQGKSRLLKKFGATVRRLDKACGPFGWTAWILFPCQTLMQRRDHYTRYAIGRSRTLGDAESCFLVWLFHWPARRVKLHPRRASRFRPELVLENGKQRRFDTIVIGSGSGGCACANLLAQSGQRVLILEQHTKTGGCTHSFRDRGCEWDTGLHYTSAGMGRSTCRPGAIMHFMTQGLQKWTPLQDPYDEVIFPPDDFVKLGVPNESSYRFVSGADETIQSVLASIDPEHRELEKRARLYMDLCTDINSGFTALGISRVLPSWMHFLVRSRIDRLMKFAAMTVRDVQYGMLNLGLTIEELLKDGCPPAPAGSEPDPSIRRLKAVLTHPIGDYAVQPRDATMAAHGVTMAHYQDGACYCVGPTQQISVRSSSMVREFGGEVLTDATVREIILEHGRAVGVRVSNTSALAECKSDAERAQVPVTELRAKAVVCATSVYNLYNNLLPQDLAQVKEFQDPEKRTIQQSNGHIFLFCKIKGDPTELKLPAHNLWYFNSYDIDDAFEAYFTDPVGQRPPTVYIGFPCTKDTSWKQRFPGVSNCILISDGLWEWFEKWQDKPVHNRGSDYEEFKEKLSKHLLEILFEFVPEVKDKIEFSFLGTPLSEQTYLNSFCAGSYGTKCLPSMFAKSNRRWTTSPHTSIPGLYLAGSDAFLPAVCGAMYGGCFGAIAVLGHLRALKLTLAFIAHFAGCITDEDPKIGWIQAYILAWKKFMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G504</accession>
    <name>B7G504_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_14427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182330.1">
        <property type="nucleotide sequence ID" value="XM_002182294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G504"/>
    <dbReference type="STRING" id="556484.B7G504"/>
    <dbReference type="PaxDb" id="2850-Phatr14427"/>
    <dbReference type="GeneID" id="7202962"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14427"/>
    <dbReference type="eggNOG" id="ENOG502QSK6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800404_0_0_1"/>
    <dbReference type="InParanoid" id="B7G504"/>
    <dbReference type="OrthoDB" id="424372at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044966">
        <property type="entry name" value="RPH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36359">
        <property type="entry name" value="PROTEIN RESISTANCE TO PHYTOPHTHORA 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36359:SF1">
        <property type="entry name" value="PROTEIN RESISTANCE TO PHYTOPHTHORA 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="136" mass="15304" checksum="1E61727E990FED20" modified="2009-02-10" version="1">MATDPAVLLGRFDWFSSVYNMDISVQVLGYWWWWLFIVPSLRSRRPRGPEKRALDVAFLATPAVSLLAPVATKDTAAIWTANLVVVLAAYAWAYATTQDDNDDSNNSDDDANQPAWLKFLYKSLDFGSGRERGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G651</accession>
    <name>B7G651_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_38534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182514.1">
        <property type="nucleotide sequence ID" value="XM_002182478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G651"/>
    <dbReference type="STRING" id="556484.B7G651"/>
    <dbReference type="PaxDb" id="2850-Phatr38534"/>
    <dbReference type="GeneID" id="7203294"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38534"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_2_1_1"/>
    <dbReference type="InParanoid" id="B7G651"/>
    <dbReference type="OMA" id="RWSAYIV"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="204" mass="22184" checksum="9209854DD21F3501" modified="2009-02-10" version="1">MMHGSQALLQAAKRKVSAIASNAITMRSITVGTDMISSVISLQKARPWYMSDAEGSNMADDNAVTLKDLFKKQTVALFGVPAPFTGTCSNEHYPGYKALADDFLQAGVDRIVCYSVADPYAMDGWAKALKNDAEKITFMADPDSLFAKAYGLDAAYDAVSLGQRSIRFSMVVADGKVEAFHKVDDAVKDAETLLADVKEWKDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G664</accession>
    <name>B7G664_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_48154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182670.1">
        <property type="nucleotide sequence ID" value="XM_002182634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G664"/>
    <dbReference type="STRING" id="556484.B7G664"/>
    <dbReference type="GeneID" id="7203495"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48154"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="InParanoid" id="B7G664"/>
    <dbReference type="OMA" id="YRTVNFA"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="91"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="840" mass="93486" checksum="7E5990D977A80550" modified="2009-02-10" version="1">MGRQSKRWKKKGGRAAGGRGGGGPGRGGGGPGRRDGETYVQTVVDAGNFKLEAYYAAQGVHDHRWNEQGELVPCNTVAEFTRERLAWRNAIASILPSSFRIAKDVSPELRQKMEADLDTLLAQTPTLEDGVSAIRKLQFLPHAFQLGFDRTKIRKHPELQALHEWLKAETDCGHITRQETVSMIPPVVLNTQPNDSVLDMCAAPGSKTSQILEQLDGPRGCLVANDANPQRAYMLTHQLRRIMHVNPVVMITACDAQFFPAVTQFDKILADAPCSGDGTSRKNIGVWKTWTQVGALGLHTLQVEIAWKGASQLLRVGGDLCYSTCSMNPMENEAVVAELLRRGQGQLELVPITLQGFRTRPGWSAWKVLSENKSRRDMKSQRNKRNAQKKWEREQQQTTESKLSQNLISTPVDSSVDGSDQTLLANGVGNVEKSNNSTIEEPIEPDMNSTASPKRENMDDNDNEEERDEVKADRDMVDQRFEPTGMNQVELLEMAKQAGLEEYHSMTDVPESLQRRVKESCFPPTIDEANTYHLDRCLRCYAHDNDTGGFFVALLRKKGTISAKDRRVQRASDSTVVVEAEPPVKKARVEDDDEDDTSPTENSNTKQEVLNDGNKEDGDNDDEDVGDPDERAKGNKISDKDQGKDDFVPVEGGVLDPIVEYYGLTGPEFCRDQFMTRAGGDAKVIYYIGAQVRALIDLGIQDRVTMINSGLKAFVRNNKECDCKYRVAQEGVHFIAPHMSARKFIASKDDFVNCLQTDPTSLAIFSDEFSSAIRPIAVGSFVVVLEGYDDQYHRKMCLSMWRCRGDNINALVAKVEIDGIQSKLQSMEAKKETECTNEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6L6</accession>
    <name>B7G6L6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182751.1">
        <property type="nucleotide sequence ID" value="XM_002182715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6L6"/>
    <dbReference type="PaxDb" id="2850-Phatr48286"/>
    <dbReference type="GeneID" id="7203402"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48286"/>
    <dbReference type="eggNOG" id="ENOG502S61P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641694_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6L6"/>
    <dbReference type="OMA" id="GWYIADT"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855478" description="Plant heme peroxidase family profile domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="4">
        <location>
            <begin position="92"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="428" mass="47110" checksum="A7E311801EA79823" modified="2009-02-10" version="1">MKLSLKAAPLAVLLSLTSTLAFQSPHPLSSFTSARNSRLAMDRRGFGNALVGTTAATLWNANIAVTPANAQVFFDPAMYGDQELRVGAVDSVRESVRRAILKNPQLAPSFYQLALLDGLSFDSKTQKYGPDGSILKVVLSTKADDAYTKNLQQACLTLIEAEKNLRKKVAITIADAIAIGGSQSIESIGGPVLAVQLGRADAPIKAPVSDVPIDLFSGKRDFADVQNAFRNAGLTDREMTALLSGLLTLEYVEKTRTVEDWKQSARPRFREPGKMGRLSEFKPLTDDDIAQAELESDPEYEDPDDGWYIADSFGSRESRFGDRLAKDQINEKTFNKYLKDIAEKSKKQGPDAFEEYGWIAMLVMDKDSPTSSTWLNKYAGSNLSYIKDLSISYNSLTQLGAVYTGGKYENLLKNKPRKSLNDDDLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6T3</accession>
    <name>B7G6T3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182912.1">
        <property type="nucleotide sequence ID" value="XM_002182876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6T3"/>
    <dbReference type="PaxDb" id="2850-Phatr48342"/>
    <dbReference type="GeneID" id="7203803"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48342"/>
    <dbReference type="HOGENOM" id="CLU_838009_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6T3"/>
    <dbReference type="OrthoDB" id="10543959at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="43212" checksum="41560A26703120E3" modified="2009-02-10" version="1">MRLSGRPVPKVPRWSYLRRRRQRVGRLPCLLTSKRYVGLCVMVALFLYYHQDLRPPRFDQSLSALRASQTPRDRKQATVVKSIVMVLFGVPKEFPTVWRFYRKYLMDANPEIHFSVAIHLYSDIQVLTNLKNNETSVAIASADDIRAILSNTNATVVQSSQLEYDQSLTWIRPEHVVGRMKAPPWTVDTMKNMFRQGNSMLLAYQEAVRSFPDADGYLFARSDTLLIRPTVLRTRNVQANDLYLPSWQVFKDEYVDRFAYAGGQAAASVYAESKAIAFAEYIRSDRDDFWRCSERLLRIYIEEYNNNTSRSNSGSDRPFTVSVHLESRKLKWAPLLRVRGGGMLNERDYHDFVDKKWSGADYPMADFLSSKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7B8</accession>
    <name>B7G7B8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183002.1">
        <property type="nucleotide sequence ID" value="XM_002182966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7B8"/>
    <dbReference type="STRING" id="556484.B7G7B8"/>
    <dbReference type="PaxDb" id="2850-Phatr48489"/>
    <dbReference type="GeneID" id="7203771"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48489"/>
    <dbReference type="eggNOG" id="ENOG502S9WP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063407_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7B8"/>
    <dbReference type="OMA" id="GANDEYD"/>
    <dbReference type="OrthoDB" id="200069at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29052" checksum="7D3E5AFF4FF386FB" modified="2009-02-10" version="1">MTDNWDDSDDEWDVDDDALDQKLGMKKVAQNLPTFDDEEDLALKEKAAREQAENAELKKKGRALASKKQAEQERLEELEIARKAMELEAEAMANLSPDELRRMKQRQVEEADNALTDDLFGGVDAKAGKGATGGAAAAAGDKVIMKDVKDHLKHARKVAECMQGHGKIHLAAAFFKELLQQSKDVLDDDAITEIIKTCNVIKNEKVQAAKRVTKVKGQAQKSKKADKAAEAKALQKQVETFGANDEYDEYDHIGADYEDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7P2</accession>
    <name>B7G7P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF389 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_29666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183180.1">
        <property type="nucleotide sequence ID" value="XM_002183144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7P2"/>
    <dbReference type="PaxDb" id="2850-Phatr29666"/>
    <dbReference type="GeneID" id="7194790"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29666"/>
    <dbReference type="eggNOG" id="ENOG502QWS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675229_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7P2"/>
    <dbReference type="OrthoDB" id="543859at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44037" checksum="CB0FF298F240CA23" modified="2009-02-10" version="1">MEGIQNTGSDSSKANVTVVTELTSSIPAIIEKEEFPDRVSVLRFDESVLAPAFRGDDAVFKDSQVSRIVDPAEHIESERSAGTQSKGTTSRPTFQDWAKIVRVSSRFSEVNLEQLERVRMMHDRISEGSEFTFNYNTLLLVASILAAIGLAANSSATIIASMLVSPIMGPVVGMAYGTLIMDWKLVKKSAWTELVSLFVCVIMGAIVAACIGPTDLAENWPTAEMDIRGRKQNFFVGIPIAFFSGLGVAVSLLDDQTSSLVGVAISASLLPPAVNAGMMWVAYGFTEVDVLAGGGATVTDFVAGLLNITVDESSDILADFRGDSGQKAPDTKRDFNAMGGVSIGLTLINILLIWFSSMLMFRMKEVLPIKKNIFWSDLGIARKVYQRKAIITESTDTTVPQPAVVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9M9</accession>
    <name>B7G9M9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183921.1">
        <property type="nucleotide sequence ID" value="XM_002183885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9M9"/>
    <dbReference type="PaxDb" id="2850-Phatr49145"/>
    <dbReference type="GeneID" id="7195647"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49145"/>
    <dbReference type="HOGENOM" id="CLU_065914_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9M9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="34490" checksum="F6D6981A2C56631D" modified="2009-02-10" version="1">MPQSTIPSAPSRRSASSTYDPALVQALFEQAYHLPGNDTAFQDWLAYMGNNHPILGLCLAHPAHPATRATRLLMLLASVTFGLVITNIFYLTWIYYEEDYEVELLALNTTTGVQLVDNTYGSVQVTTGMLILWFIGGMVHGVFDHVLWCMATGIFPCSGFPNVAKRSNNNNNNSNHTKGRERNWTLYIMIVIVMVSTAIATLGVVLNSAMNAEDRIDDVAQRAPAETLNSVDGAEVGEFMLGFALELVMAYVLYFPLGETILFTGILSCNGRLAMFAGRPQEIEQLREQQRPQAKTKSLQTESRIQSKQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9V9</accession>
    <name>B7G9V9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183843.1">
        <property type="nucleotide sequence ID" value="XM_002183807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9V9"/>
    <dbReference type="PaxDb" id="2850-Phatr49222"/>
    <dbReference type="GeneID" id="7195688"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49222"/>
    <dbReference type="HOGENOM" id="CLU_1520742_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9V9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="177" mass="19299" checksum="F9197B658CF35032" modified="2009-02-10" version="1">MGSGRGGPRNERFPPFHSLVARCGNGKDFGLDLIERGAMGGAVPCRSHSVDSTANKRLPQIGCATYKGLQGKAAHVGTCVRSGAPHRHTWSGKKEAQVEKQSNPISKISPRVQSMTIPYPRDLVLTVMSEKQQEWRRPGQPVELRVTHASLLQVASLVAEQTFRFHAWPTQVPLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA32</accession>
    <name>B7GA32_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183878.1">
        <property type="nucleotide sequence ID" value="XM_002183842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA32"/>
    <dbReference type="PaxDb" id="2850-Phatr49281"/>
    <dbReference type="GeneID" id="7195570"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49281"/>
    <dbReference type="eggNOG" id="ENOG502SVGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1144464_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA32"/>
    <dbReference type="OrthoDB" id="43004at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="217" mass="24358" checksum="4928BA48755F63D8" modified="2009-02-10" version="1">MPVARSIAKLLTSPSKVAQALDWKKASGSILSLNVCRNGIDIAIASHPSSDEPIEHMPTIPLKLVIQNHQKILARSVIDDIVDIVNENQVCGMVVSWPVQKEGWCGAPCGRVLHALDQITAQSNILNGSRPICLWDTEHNLPQEDEWGRDPVYAIPSEKTEHRASIEQYQDHSCQATDIWNDFSLTHWPEYYLNQQKRELERAQRSLVTAYSQAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAH0</accession>
    <name>B7GAH0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_40101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184196.1">
        <property type="nucleotide sequence ID" value="XM_002184160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAH0"/>
    <dbReference type="STRING" id="556484.B7GAH0"/>
    <dbReference type="PaxDb" id="2850-Phatr40101"/>
    <dbReference type="GeneID" id="7195899"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40101"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408553_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAH0"/>
    <dbReference type="OMA" id="NIRQSTH"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="275"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="673" mass="76518" checksum="F35C2DBE09844B0B" modified="2009-02-10" version="1">MASCDEDGKTGTTKANGQDWMDVTSLIETCASSLALADPFLCTKSFQLHDAMSATQLMDKKMDSCEIPASLVILDGMEIPPDDKVTFPRPIPLGLRDSFTPLPWDELTLKDAAVISLHIMVRLQALLSGSSVEESTFTCLYAHCAVLIDMKARLLPDSIENRLGDLLKEKTKTEKAQFVVFAATLALVHFTDSFRESILNADIYEEEDFVSTTSSITVFTEKVLDAATRIILEMEDAKGSEEQRVVLNVLKFQRCMLSICSKTEMEQFVCPILFSSTSLNRLQRTLDRISLQDVNILNRSLIVLNLYFNERLLGKFSLAEWTVDNIRQSTHVSESLVSNEHVIAFVNRLAKPVYDTLKLRLLNRNRQRAYIEAVMLQDWVVLQNEAQVLDAHYRRENGVDPSTQPRLSQYVLTILIQLMDRFIASGVDQGIFYGHQDLSFAFWYRDFLLSALTKNLSSMQSSRRAAQVISKQTNVKEQQGNNKKRTKKALKNEYLDSSPKACPTPDDLENEFALSIISCKRMLCRGIQRFFVSLRQAGFLSEPVYEFTSAKAVFEKRFEMFASIRQPPPLSYNDYLEGSNYTHVPQEELLQSTAEWFQSCNTAIESLLEEERGLNKMYTPMRADEIQSLRKVCLGNSIYVMKLRQLIANPPSHPPKVIFDFDTHSEFCTIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAH8</accession>
    <name>B7GAH8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184076.1">
        <property type="nucleotide sequence ID" value="XM_002184040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAH8"/>
    <dbReference type="PaxDb" id="2850-Phatr49409"/>
    <dbReference type="GeneID" id="7195903"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49409"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405211_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAH8"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="379"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="606" mass="67465" checksum="3CDB440BE4A19154" modified="2009-02-10" version="1">MVREDSTHEVIVSQCNKVFIVLFYEEIPYSGSASLARWRNSPIPAKSEISNFRTVALVALFLFPTLAEVRISAQSIDGRSIVTSEAEEDEAVVSCTLDSLSIGGQQLNVLDSISFYLHRNGEPEACGASVLSESTIEKGLSQMECKKEVDKYQLEALLTAVFAEELAASDCGSNDNSTAPEGFLHYCDMGVDRTIVQNDYDHLVRIPRKGNLPCRFFSREGDRISSFEDILRMAEKAETRECTEENDVCTDRMDLHLYAAPAGRVFMFAPSYVGEIFQISHVKDSLGQPISLEVLSLDPRVFDIYNFFSADEAHSLIDKAVKETSPTYRLHRSTTGSATASIFNKRTSENAWDTHGTLAQTIKRRCLSVLGIDEYQESLTDGLQILRYNQSNAYTAHMDYLEDKDGSQVYDYESVGKGGNRFATILLYMSDLGEHDGGETAFVKADSPGKEHVPLHRAIQQLRDSGDASTLTPDSWEEIMAAQCRARLSVRPKLARAVLFYSQHPNGAEDKMSFHSGCPVLGATTKWAANLWVWNAPRPEFEGAPLKKDLSNVTKAESAASQQLRAVFRNSGKDRRFEKAELYFDEDGFFGKLGPKDPPISLTVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAI2</accession>
    <name>B7GAI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_30334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184078.1">
        <property type="nucleotide sequence ID" value="XM_002184042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAI2"/>
    <dbReference type="STRING" id="556484.B7GAI2"/>
    <dbReference type="PaxDb" id="2850-Phatr30334"/>
    <dbReference type="GeneID" id="7195792"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30334"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAI2"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="5">
        <location>
            <begin position="327"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="645" mass="71020" checksum="3BB1ECDBED6CA2B9" modified="2009-02-10" version="1">MPIPMDVDPVDDDPRPSSSPLSSPLLLRTVVPITREEEARQAIELLRGNDMAERVAAAHRLDAVAAILGEERTRNELLPFLSDAVDDEDEVLLAMAQALGRMIDLVGGPTHAESLFLPLELLLSVEETTVRQAAAESTLFIASQLSESDYQSCYAKMIARLATQEWFTARISAVGLLSQAYTSLRVEQQKEHLEFYANLAKDDTPMVRRVAAQYLGQMVQNVVRATGRSSLSETGSVVTTLLPIFEEFSSNEQPDSVRLQTTENCVAFGQVLSEVDGDLNESEQGLLKKVLPLILATIDDRSWRVRWTTAAKFSEVISAYGRLPDVMDSLVQGYEKLLQDPEAEVRTAATFNLAHVAKGDAQVLVPPQHPERLVKRVTSLTEDESEHVRAALAMVATELAPILGREGTITFLVPPVLLLLRDAASEVRLNLISSLSALNEVIGVDLLSQSLLPAILDLAQDGKWRIRMAIIQLIPLLAKQLGQEFVSEKLASLCVEWLGDDIATIRQAAASNIKDLTALFGTTWATEFLLPSIVDIRENESYLRRLTALQACSMMATEMDSDSARIEILPLILEMATDLVPNIRFNVAKELQSMAHACGISAYESQVLPVLNMLLEDEDRDVRFYAEKAATALDETFAAMDALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP0</accession>
    <name>B7GAP0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184110.1">
        <property type="nucleotide sequence ID" value="XM_002184074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP0"/>
    <dbReference type="PaxDb" id="2850-Phatr40172"/>
    <dbReference type="GeneID" id="7195818"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40172"/>
    <dbReference type="HOGENOM" id="CLU_1374593_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAP0"/>
    <dbReference type="OrthoDB" id="46218at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="20873" checksum="7E891461F6B92271" modified="2009-02-10" version="1">MVEVTQDAPRMDITTFAVNLPPAIVQGFDEPIVDDSVGISLGDQGIVGTITFSKKAATIWFGWGSLQSSKTSGPGGNAGYGATPVGAKSLCVGTAPNLSMGPLVVAMPRPRYKGSLSISAEPSTSKLIGYDDEGDEMVARQMSSRLSQRLGIAIFVSCSFTGAPAMATDGVDQSIVQHRAAAFAEREVYRILNKKLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAZ7</accession>
    <name>B7GAZ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_40278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184164.1">
        <property type="nucleotide sequence ID" value="XM_002184128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAZ7"/>
    <dbReference type="STRING" id="556484.B7GAZ7"/>
    <dbReference type="PaxDb" id="2850-Phatr40278"/>
    <dbReference type="GeneID" id="7195870"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40278"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012692_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAZ7"/>
    <dbReference type="OrthoDB" id="42699at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012226445" description="Protein kinase domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="230"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="934" mass="102712" checksum="D58B011503F6182D" modified="2009-02-10" version="1">MADAIFFSIVALAKAGIECCRNAQICKDEAARIGKRLTIVVARANEWGAVCESARLFHFHEVVENAFLCLQAVSSPRSKRSSWNKLFKSALQSTSLLDQILEAESHLNTAINDLQMEQSNAIFSQLVDVSKGVAELLDHFGTLAMSQSNPSVTIQQQFDKVLADAQAQAPEVAVSITGDTINHAVREYDSLNHAEAEIVLSQQQQKILFRPSKEDVLAISLNSSSLKFSDDRRNLLGGGGFAEVFRGTYDHRPVAVKRLKAYDGDLASLSQNQISRDVERLAAEAILTHKCGKHSNIIHIVGCLTILNEVERPLIVMELMHTTLFDALHDQNQKDTMGYSRRLYLLKGIAGALEFLHLQGIVHHDIKSLNILLNNQLTVAKLADFGESKVKGLHTTKFRLNTIMATTSHKGNQVAGTAAYQAPEILSEEVSDTSRVCEMFSFGVTVWECLTGSIPHMGKKESSIALLAANKKHLPMLDVPSRPVIDLPEMELASWKALKVIATMCISRDRSIRPTASVVVGLWHRVKTAGKVEPFSFSLENLSTAKTGGIVNTLLPTDFGTQGSASQAQDHEEESKAEYGTFSKKRCYSGLSVYASIVVLLGSIVVLTVTLVPRTSPESPSPLLARLSLQTTEDLYDAVDVYVGATRPITSIAATKYGYPIGSWDVSQITNFTQVFDGLGRNRAIRMFDEDLSSWDVSAATTMQSMFNGADAFNSNLSAWNVSQVTDMSFMFWGASTFNGDLSSWKVDRVENIKSMFGGAGAFNGDLSAWNVSLVTDMSFMFWGASTFDGDLSSWSVDRVTSMESMFEGAGAFKGDLSLWNVRQVTDMSFMFWRASSFNGDLSSWDVEQVTGMQSMFQFAAAFNGDLSNWDVRNVTTMQDMFYGATSFTGTLCSWLEKLPLDCNVDKMFFMAQSCTDRADIILPIGPMCHTCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBG8</accession>
    <name>B7GBG8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_5608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184462.1">
        <property type="nucleotide sequence ID" value="XM_002184426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBG8"/>
    <dbReference type="STRING" id="556484.B7GBG8"/>
    <dbReference type="PaxDb" id="2850-Phatr5608"/>
    <dbReference type="GeneID" id="7198320"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5608"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_5_0_1"/>
    <dbReference type="InParanoid" id="B7GBG8"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="161" mass="17840" checksum="63762B8B723663F0" modified="2009-02-10" version="1" fragment="single">SASENLPPRTLARVAREVRDLHKNPPEGVRLVVDSDTGVPSNLSELMAEVKGPTGTPYENKFFLLKLVFSSDFPAVPPRGFFLTKIYHPNVDNATGAICVNTLKKDWNATTALSHVLAVIRCLLIVPFPESSLNDEAGKLFMESYEEYSKRARLMADVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBU5</accession>
    <name>B7GBU5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184589.1">
        <property type="nucleotide sequence ID" value="XM_002184553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBU5"/>
    <dbReference type="PaxDb" id="2850-Phatr40550"/>
    <dbReference type="GeneID" id="7198448"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40550"/>
    <dbReference type="HOGENOM" id="CLU_1216797_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBU5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="237" mass="26235" checksum="042A21BDD7BD001B" modified="2009-02-10" version="1">MCTFIRMMRMNNFAVTLMRQRNDNDAAKTILRTLELLRETASGFIPSTSELERWRLMGEVVSVVLSNAFVNELCGAVDGVDSSTPAFYSRAMIFSVDSRRIATPTSENLATISMVLLFNAALALQRDGLRTGQSSVVQQALPVYMKIIGILGPLDLHGSHIPDTLKTISLATSVNIAHVHLEFYNRLEAKIWQTHFSVAFQCMERSHMNFDDFAIFAMNAFVFSIEGGVGFLTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBV1</accession>
    <name>B7GBV1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184593.1">
        <property type="nucleotide sequence ID" value="XM_002184557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBV1"/>
    <dbReference type="PaxDb" id="2850-Phatr49775"/>
    <dbReference type="GeneID" id="7198351"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49775"/>
    <dbReference type="HOGENOM" id="CLU_380576_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBV1"/>
    <dbReference type="OrthoDB" id="211168at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="332" mass="37011" checksum="15DF0362F67B9A97" modified="2009-02-10" version="1">MSEPRSRSVTAWNVNQTRGKASRLFVLVVCWIVSFAIWELAKSFHATSVASINSATSTTREKIKQLIVRNETVTSTVANTLIAEPQYHASSLGPNASMPTTLHNETADDNFSDSQRNQSGIHAVMFSKYPAPIVSEDDIRQAHMFVENRKSAYNTLQLDYRWQLRGVGYLYTTLRMVLLATLAPSNPFVGRKQRIVIQNVFNQTYTQTECEKLTLWVRVNGPEIFAGAAQAVQPTSGTSCYWTFEYDLNVPGSYSVDVKVLLWNGQAPIGGTQDGQCDASEGAPTSSTVQQFGPRHDGFQGFKMYSVTPMCCEVCTRTPYSPPRTVQVHQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBX5</accession>
    <name>B7GBX5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_40578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184601.1">
        <property type="nucleotide sequence ID" value="XM_002184565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBX5"/>
    <dbReference type="STRING" id="556484.B7GBX5"/>
    <dbReference type="PaxDb" id="2850-Phatr40578"/>
    <dbReference type="GeneID" id="7198367"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40578"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226220_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBX5"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC44000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="860" mass="95132" checksum="75FB8916B5EE285E" modified="2009-02-10" version="1">MEMSSESDEPPSSPSAVAPSQSEEIRLDPDQQAAYDAAWHALTQSLTTDLDPPPPTVVSLDDPNRADRDADEEDAPPVALVTPMRGHHALFRALERLEGNDKREETLVTRAPLTNTLTSVVLQDSYTDSAAALAALQAAGSSFPRKVCQHPFRKNDIVWVCRTCQADETCVLCHNCFSQSNHEGHDVAFYHAQAGGCCDCGDPDAWDPDGFCPHHGPNAVNASDARLPEGFTHRVQGVVPAVVDWMVRDVAAVGETGYARCHAPTPLRRASSDHEDLPPSLPSLAQRSASMPLEQELQSVGMDIDEELFAETAENDETAADDEDLLSDRFHSVVDSLRMYGPSNFNHRTHVFSPTAASKSGAAADSLRRHEARAEALGRKGATGGGLFLVLHHDDVHTSQSWLDALREFLGSTNYYTDTLLGKLIKALKTYGQLIVWGTMEVATEVGWTQVQLWMDGDKVASTRIGALLLEHASRLTRHGAFCSILTREELWLEQKAVGVLQWLSKLAESCHPFCNTVAACILPNRHLVPLLEADFKMSARVMKAWYSLLLTLLAVPTFKSHLAAAYCDTYRSVTAKYARGMGVLERSGYQLSVQFLNRVQYVVDLVQGRDLLGKLGKTLLDTLLVARRPRNLNGRLNPNHHVLAHRRYSPCISDLKCVLNVKGMPRLFAAKGGTFLGDWIEVLSIAQFMDPQSWRHWTFGHVEDESRGWVGAFNASISLGSIFERLLSWEDEEPSPITDSTSPLSRNLMPCLELTFHILVEGVSRWQKSEVLFYDSTPNSSVIEVHKRCPASLPFSTIAAQRGTALAMRQLPISQVTPFSFHLPLHRFVAGCIRELCLRHPRFVRRFGAATGLPWAIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC42</accession>
    <name>B7GC42_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEACH-type PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184650.1">
        <property type="nucleotide sequence ID" value="XM_002184614.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr40677"/>
    <dbReference type="GeneID" id="7198586"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40677"/>
    <dbReference type="HOGENOM" id="CLU_226219_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC42"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="2127"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2049"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2058"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2092"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2243" mass="247892" checksum="62BEA9099DB4CFD8" modified="2009-02-10" version="1" fragment="single">MVRSDDESDFDQNGEPPINPFSASNCEPHSSAASALKEDSFQLSERSAAIVRAAKAAGHKRSDSMLSGDDDSDFGEASSTDRTGRNASFAYMEEASMEASLLNHLSEDASAMESTRGGTLRPMVTKLSPSGRLGRRRTEILSSDEVLVGGDLEGIRKAPSNDLDASYVEMDFALGDALPSPYDTSETFPIRETSLMTSTEIDDNGPKNVQAKAPVVVDIGQIGVPNSLSPSSLEPTYEILKAYRIIDDRTVSDDILPGAEAKVLCSLFDGFCCPPLELDSARAILKMEMSRIYSKDVSIPIPEQPVIQMLEKDNRVVSLLLSGVEPSPAILQLPLHFAASFLRILVRLLTHETDPEYNQTCFLIEKDVFIDRGSLESPPVHPDHFTSRPHMLYSSARFQCVNAWKAQKRELVSDSQIAVEKVLDIWEQAAATPSCALLLGPLGRLLGVLGAAGVNAKTIRRVLDLGQALELPILARVSIVRALTTAATGSSRSLILPKLPPENFFLFGQRGLKRKISGLSTWPFRNDFGVAVWFRAEHFGSSSNVTLISARSDDGGGIEVSLVPLDEKTNDVCTVSVSVFDSGNGNLVAHSVKVSACVLLPRVWYHLAVRHTRSRLKGVFSLSTRQQVSIMVDGKVMLTAPLPFPRISDSDFEKESILQSSLRRVTLRSSLNLTLEFGSQFDGQAGTVYIFNDTISDASFRTLFELSGGSSGALKRSSSRKNRWDSRRSEIVRKSKALDMKTLNDEADELVVSQRKKSGSRQKEMKARVVDLLEADEIDDNELALELQNPSFGSKIFVVWDPERVTDSCLAIELHVGAHVQLEQAYRWFSNSAQDVISYLGGMQLSVPLFRSLLSDRATVTHESQRLELAFGYSLQSLVDLISSCVKDHDENARELLRCGALDVYEHVLTTCRNSFLSKPDEGSVFQALNSNETIANSFVLSLLRLRSACEHYVGLEAKIFSRFLFNFGLWIGTSTTASALDLALLPILAILTRSNGEKVRDCLGSKYIVQGLCELEAKGSTSIEVNEIAASKIDKKNLFLAMLFDILVIGTSPRELAPFLNFLSSILDAQRWETIPSDGGTNDPHSSLQAYTKRLAIDCSIVLFMLLQVRPPVNGLYMSLAHCCGSVQGGAAWILSSLVNSTDDNILSLGVRSICSYLELASKGPDSGLAFGPILPSEPEAASGTDVSSSVRRGANRMAQIAKGIAAMGPTGSKGTSLYPKLTARVIFKLLWHLLRSHRSHLGPKTRVALLFWIMNGNNLTVSAIGSIGILRRYFVTEDAISGYQISFIWAEKKLLEVENIGGHAIQDALAVGTVLRLLRYLDSRVKDQWLSDLLDLARGNRKSLTVLASVSDWEASLFHLASETLESFVAAQNQVDFESKTKSEEFNATTTERSDNMSTELSFVFHEQNSDSLDALRSRLDTCIDLYATLLGHILREGGNKALSALENVSALERVCVNGHTVLLLLLSSLCANVFENGTLLEIGSISAEDWHDVDLEAESLPLKQSARLVTDAILSNGMKGLDMTTAVRSWRSLRHLTEVVVALATKSGLGVASLFDYSSQKASAVDIVSNGLHGIHLPESKVKGISAYEYGDMVKAIRESALDGAEKGQDIDRRLCVNIAAQVLTLLDAFIFPDSLDSSLPASHIHGLALVRSSEPRLGPSQGTLLASAIRLSLILLALLEPSSVKLLQCASRLKCLLFWALELVREEPSLSEVVVQGNMAMVDRLLLATVLHCHRALGRCSALLIEVESSPFETYFASREDQKRHHRRLLRVSLELRDIASTVFRGRNHILKSSLSPAAYGDLQASLEGDHRIHSKEGVVREFLCSRWVTKYQDIETRADIAVPEQATMGTIALNSEGPTVQGFIVIEKLAQEAEAIVVDYEKALHSCFESYLESQRKWAETDAVRDLEYDGDTITSRLSDRHDSAIAELTKAKSRRRNRAELRWHRLERKVVEPWKLAAHWKLAQYSDPIGRRLLMVQNRYFDSHEDASYEVSLGKERDREEEYRSSVRLEREKKDLAEVMRRNADAFIVENPVMDCEPVEDDTMHAVSDSEGSTDLELVSDTESNDVFGRKDADDTSANSDGNPDEVQRDEEWDKIGASDIDNIGADGDIDGWAKIFMWSESESVVARFENVMLIELRSYTEGKVLLTNHGIYFRQISDEMNVMTKEPLGMDDTGPSETKDRRWRLCRLSEIQGRRYMLRQQALEMFFADGQELFINFPAGGKDRDRFYAKIRNSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC92</accession>
    <name>B7GC92_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184681.1">
        <property type="nucleotide sequence ID" value="XM_002184645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC92"/>
    <dbReference type="STRING" id="556484.B7GC92"/>
    <dbReference type="PaxDb" id="2850-Phatr49903"/>
    <dbReference type="GeneID" id="7198605"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49903"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_3_0_1"/>
    <dbReference type="InParanoid" id="B7GC92"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="71561" checksum="BAC7724BEC8C5788" modified="2009-02-10" version="1">MWVFSSTCRCGVRRVIPSWVGATRMAASTGAITKDTPPNGRAAGKNVSGPKVNGRSRSETPSWHPGTATFSSLSDTTVTSKSTIATGTDGSSTSPRLPHHSQPLGFPLPEDEHACSVSLPTWSAVVGYEEGDPTTVQAMKCGYPRFVYHPYVLQLMEYVLETHGHPHEDCLVLPSANAAIRCRSFLQQAVENKPPRVDNALLEKIDGWPSGGGTGDYRNTDIRLVRVGAADVHAVIFPAETLAGTQAKSYWQHGGEVVSSRRAARCLHDLGVGLHSRITDGAWICHDMMPQSDTAPDYLRRQIARWAKVPSADSVFLAPSGMASIYTALRSARRYQMEKGPNATGGTSIVFGFPYLDTLKLCSRDELCPGGVEFFGHGDAQDLDSLERLLRTKGKNAVCAVFTEVPSNPLLQCPDLYRLRQLADEYDFLLVVDDTISNFLNINVLESGLADVICSSLTKLVSGRGDAMAGSVVTNPHTAGGRWMQRDLAQYYDETSHGGLYEGDACAMVQNSQDFVSRNAVINETSEALASWFQQHGDVEKVYYPKLVSTRDHYEAVRSGGYGGLMSVVLEPHMCQRTFYDALNVAKGPSLGTNFTLVCPYTLLAHYHELDFAMSYNVQPNLLRIAVGLEPLEVLQDKFEEAFTKSRLHPKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCE9</accession>
    <name>B7GCE9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSP70G</name>
        <name evidence="8" type="ORF">PHATRDRAFT_49949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184797.1">
        <property type="nucleotide sequence ID" value="XM_002184761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCE9"/>
    <dbReference type="SMR" id="B7GCE9"/>
    <dbReference type="STRING" id="556484.B7GCE9"/>
    <dbReference type="PaxDb" id="2850-Phatr55122"/>
    <dbReference type="GeneID" id="7198546"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49949"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="B7GCE9"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853113" evidence="7">
        <location>
            <begin position="31"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="936" mass="103260" checksum="928C38F0C453127D" modified="2009-02-10" version="1">MRLHSHRAVVAAASFCLWTCLASFSGTVEGRAILGVDLGSLYMKVALVQSGSPLEIVTNLHAKRKTEQMILFDQQQRFYGADASALLARKSTKTPSAMSVLLGRDEQHPTVRVLAERHYPVRPVYNETRAGVTLTVDGVEFTPEELVAMVLSHAVDISVAYATEQGSTIAPPKDVMLTVPSYATQPERQALLDAAGLAELNVLGLIDENTASALHYAMDKSFETPQLIIFYNMGASALQVSLIRFFNYEQPQKFGKPKTVPALEVLGKSWDATLGGQAFDQIVVEYLADEFNKAWHASTGKTEQDVRSFPRAMIKLRLQANKVKHVLSANSEIPVYMEAVHDDVALSTTMTREQLELLASSLWARAIQPVTDVLQQANVTLEELTILELLGGGMRVPRIQTELIENGLGGNAALLGKHINSDESMALGAAFAGANISTAFRVRQVGMTDLNPFALSVTLTNLPDGDDTASEASNDEWSKKATIFKAFGKVGVKKTIAFTHDTDVHCALDYDTDGEASVLPAGSQTALERYRISGVAAFAKEMADKGLGKPKLSLQFELSASGITALVKAEAAVEETYTVEEEVEVEDDGVTNTTEDESEEEKKNDTEADGENKTDDSHEVKKEKKTIKVQKTLFGLRQRRPAFVVKEKKRLHKKELTVDTYHVGRVTPYSAELLAASKAKLLEMARNDKERMMLEEAKNRVESYIYYIKNKLTDDEEEIGTVSTKEQREECQKAAEAAEEWLYDDGYSADLATMEDKYAELSAPFEKIMLRVKETAARPEAVKVLEKKLEEVEALIKKWETSMPQVTEEERTKVLDQVEEVRKWITKVEGMQAKKKPHDEPAFVSADVPLQAKDLELMVVRLSKKPKPKPPKKKKDDKKPGNSTDAMEDTEDPAAVNKTEANSSESAENKSEAEGAQSNETLPEPTSGDAGMDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCL3</accession>
    <name>B7GCL3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DETOXIFICATION</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_55128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184828.1">
        <property type="nucleotide sequence ID" value="XM_002184792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCL3"/>
    <dbReference type="PaxDb" id="2850-Phatr55128"/>
    <dbReference type="GeneID" id="7198708"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55128"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610417_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCL3"/>
    <dbReference type="OMA" id="GEMPERM"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF46">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="47327" checksum="76300EDEBA39EEBE" modified="2009-02-10" version="1">MLADPVLSLIDTAYVGRLGSVPLAALGACTSIFHLAFNAFRATTAATTSLVSSRLQQDEQKAREVTQTSLLLGVTMGLAVAVTLWAAGRPILASMGVPSDSVLFPDACAYLYARCGAAPVVLWIGVAEGAFRGYGDTIVPLVASLTAAAINLVLDPILMFTLGWGVRGAAAATALAQFGAAIVYAVQLKRRNMLPALRRRSQSSVSSAATVTTNQKTAAAPALPSTSASSTATTTSRWDVIRTILGANVAMMTKQGSLLLAWAYATAKATRMGAAHVAAHQVGLSVWLVFALILDGAAVAAQVLASRAYANRDRAAVRTLLWYFTKVALLQGVVSLLLVDGLDWILPGLFTPDRTVQAHLHRLVPYLAAQQVLVSLTLVWESLAVGAQEFRSLAVGTTLATVASVYQLRQQTTVEGIWKVGIVTLFAGRLLTAAVANIRAYRKLPRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCW5</accession>
    <name>B7GCW5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_16445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + nicotinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="3"/>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184872.1">
        <property type="nucleotide sequence ID" value="XM_002184836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCW5"/>
    <dbReference type="PaxDb" id="2850-Phatr16445"/>
    <dbReference type="GeneID" id="7198766"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16445"/>
    <dbReference type="eggNOG" id="ENOG502S2KZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339958_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCW5"/>
    <dbReference type="OrthoDB" id="2157177at2759"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43463">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43463:SF1">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="365" mass="37989" checksum="A45DB9AA6B60ADD1" modified="2009-02-10" version="1" fragment="single">KAREYVDSLAKPMGSLGTLEDWAARIAALQRTLVPSVANVTCLIFAADHGMAADAEQGGEGCSSYPQTVTRSILDGLKRGVAGASVLARANKVHLKVIDLGVLDAKPLPENNHSIDGVAVSKYKLPNGTRNACQCAAMTLEETNGCMQEGKDAVRSCHFQGCQLLVFGEVGIGNTTTSSLLLAAIMGGSCSAASVCDGGATLGRAVDEAAVQKKIDIVEKALSFHRETLRTADVMSILTLVGGAEIAALVGAMQEASRLDVPFLVDGFIVTVAALVAVCLNPQCCRGMLFASRSPERGQWIALQKIREIAVEGNLPVPAEPALSMGLRMGEGSAALLAVPIVQSATAMLREMATIQDILGGGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDS8</accession>
    <name>B7GDS8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185182.1">
        <property type="nucleotide sequence ID" value="XM_002185146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDS8"/>
    <dbReference type="PaxDb" id="2850-Phatr50342"/>
    <dbReference type="GeneID" id="7199078"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50342"/>
    <dbReference type="HOGENOM" id="CLU_582014_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDS8"/>
    <dbReference type="OrthoDB" id="49012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="395" mass="45656" checksum="932F889AA8F4E9F8" modified="2009-02-10" version="1">MPGMYSSRSESTATGLTGPLKSNETENPVLYSETFQILSVDLPEISPYYRHDRRDKLGAPINDTASKDLSRLLEQPKPSRSRDNYDVRVYDHPPIWTRLKEPPRAHLRRQARKWLWKAETLYGPRGHPLVQVGNLMDTDSFVCPLTISQIHSSLMQRELGRMQGQFDQVNAIRLELLVYGVRVHDDFRQWTTDPNHVFLANTASKHSPAFPHAYQCDPSSQSSTSLTIDGSEADRLTQRIEFLVRTRAAALFRGDDKKALFIACKLYMTYGVGVNDTTRTWSIGSRFLKSYENEWKAPTISKISEMKEKVSFTHELFQMRRQFESPNFRRSQNSHFFPNAIVEKRVASMVQERIHKREEGMFLEADAIRRELWSTYNVGVNDRLQQYSLGGVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE31</accession>
    <name>B7GE31_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_16932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185364.1">
        <property type="nucleotide sequence ID" value="XM_002185328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE31"/>
    <dbReference type="STRING" id="556484.B7GE31"/>
    <dbReference type="PaxDb" id="2850-Phatr16932"/>
    <dbReference type="GeneID" id="7199175"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16932"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GE31"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="13"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="361" mass="39867" checksum="1DDC73C7C61C8899" modified="2009-02-10" version="1" fragment="single">ETEDDPHRFRVCLLREKHVQYLQQVWTKGELLGSSFVSLDASRTWMLYWALHASDLMGHRPSVNERSSGNDSEDPQAILPSPGATLGGFGGGPGQMPHAATTYAAVLALNHAVSESAMKLLQRIRLPVYSWMLSLQEPDGSFRMQHDGEIDVRATYCVLAVAKLLNICCTETLGSNKVVESVVRCQTFEGGFGGEPWTEAHGGYTFCAVAALQLLNRVDAANVPALTRWLTAQQCGFEGGFQGRTNKLVDGCYSFWQGGAASIVSAFLLFDQGMLQRYVLLCAQNVTGGLRDKPSARRDFYHSCYNISGLSVAQQVDSLPDFGHPSESVVHETHPVYNLRTERVRKMLTHWQTQPIILDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE35</accession>
    <name>B7GE35_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185365.1">
        <property type="nucleotide sequence ID" value="XM_002185329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE35"/>
    <dbReference type="PaxDb" id="2850-Phatr41388"/>
    <dbReference type="GeneID" id="7199299"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41388"/>
    <dbReference type="InParanoid" id="B7GE35"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113675" checksum="3C25F48853E94593" modified="2009-02-10" version="1">MADADAPNAPEAGLAPAVAANAPGIVGDAQAAAYAAFAAAEAQMANALAVLAGEAPPDAQPFPPPPGVADIPVGLPPAVVDAPLIDPYDSLLMRAGMNYGTRKAFSKEGYGLMSDLVTLNQKQLESLIDMMNKKHCGKSFQGAIPLGLNLVAEDLEIDIGHKTKTTLKVILHWADLQKSLGLDVNAEDYTNVVGQLARERMDEEEKILEAAKKLTPSKPTTLKDMTKWRSFFENWNSYMSQCRGAAAIPLSYIYRTNKQPKTALVGTYVNMDAYLVAQTVLSGSNFEINNQRVFDKFKEAIITTGPGWSFIKMYNQSKDGCAAILKLKEQAEGTLNESVRRDDAIKILSTTTYNGPSCNSNIDMLLQKFQYAISELVEIDGVALPDGQLVTYLVQALKDPSLSYVRDTIRTNATYRNSFPEAQLFVKTFVSLSTSKSENTPRQVNDVQTSGSGASGGSKKGGTGKGASKPTPFKGAVTARSYTPGEWKSLSKDQQEKVRSLRNKKKQGGKPEESERSVDSVARGEPVDTKEVHTSSEMEPTSDAAGLQFGRDTCVAGANTVLIGESQKSVTMRPFSGEYSALKNIPIGTVATAYTVPEDGRVVLLIINQALFFGDRLKNTLLTPNQMRDFGIEVDNAPRQYVANSKHSLYVPDSPLWILLQLRGIFSFLESRKPTQQELDECEHIILTSDVPWEPCSTDFARREEQAVKRDRSVSLVDTRGLSTGHATFSAHQYGIRTIAALQRMGWMAGLTWMCTHSDNFTSVVSNMTSSERWSALTLEVLSRRWNIGLESAKRTLQAMTQKGVRTVMHPLTRRYRTRQSHLRFPTIWTKVYTDTMFLSVVSIRQYKCAQPVAESIREIKKAVRHRLQVSRAPRRLWCFCCEWVSAIRQLTAHNIPALNGCVATELLEGDTPDISEYAQFDWYEPVWFIDPTSAFPEMKKKLGQWVGVASDVGQAMTFWILPKSCIPMARSSVARVLPDVGATDEFKADLAELNLAIEKRIGNSKTAEEDQVIDGQLANLVSGPTDDLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE39</accession>
    <name>B7GE39_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHATRDRAFT_55198</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185420.1">
        <property type="nucleotide sequence ID" value="XM_002185384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE39"/>
    <dbReference type="FunCoup" id="B7GE39">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GE39"/>
    <dbReference type="PaxDb" id="2850-Phatr55198"/>
    <dbReference type="GeneID" id="7199249"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55198"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GE39"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000003">
        <property type="entry name" value="Oligosaccharyl transferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="17">
        <location>
            <begin position="43"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="18">
        <location>
            <begin position="555"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC43089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="894" mass="100504" checksum="C1F44430E1078B90" modified="2009-02-10" version="1">MSPSTISSTRPPEPSSDLLSWVLLGGTAYAVYVILHTAYRIRMGAIDDFGLVIHEFDPWFNYRATEYLYYNGIKDFFQWFDYMSWYPLGRPVGTTIYPGMQFTAVAIKRYLLDSVMSLNDICCYIPVWFGVMASGSTPLLLGFWSPAIGCSIFAMAMMAIVPAHLMRSMGGGYDNESIAVFAMVLTFYCWVRSLRSTSGSAHAQTYVAWSVATGLAYFYMVAAWGGYVFVLNLIGVHAAFLVLAGRFSTQTYVAYTLFYSIGTALAVQIPVVGWAPLKSLEQLGPGAVFLGYQLLYVCEVLRKRQNLTRAQAWKLRVQMCAIAGALVMFAAFFLAPKGYFGPLSSRVRGLFVAHTKTGNPLVDSVAEHQAASSRAYFQYLHHVCSLAPVGYILVFFNLSDASSFLIVWATAAYFFSHKMVRLILLTAPIGSILGGITAGPTKEKKKKIPKTVGKSDKYTSESFSSFEGLAAIQETARLALNTTEGILVRRSVALVLLLIGYFLGGSFNNYSWRLSQDLSNPTIIMRARLRDGQLVMIDDYREAYWWLKDNTPEDSRIMAWWDYGYQIAGIANRTSIADGNTWNHEHIALLGKALTTGVEEGYEIARHWADYVLLWTGGGGDDLAKSPHLARIANSVYRDHCPDDPTCRAFGFVDREGTPSAMMKRSFLFNLHGHQIKPEANAPADKFQEVFRSKYGKVRIFKILGVSQESKEWVADPSNRICDAPGSWFCRGQYPPGLSRVLEGKKDFSQLEDFNRGDRDEEYTRRYFEDLKDPDSARRKAMAKEIERNKEQVDAEVQEKKHVSVDDIYNTWENTDDTTRMWNLINSNAVEELKAWLEAEPHKAYVRSEDGRGPMWWAFEKRNEDVTKLLMKAGVPYTDRDGSGKTPLDLQQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N8</accession>
    <name>B7S3N8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="6">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FbaC1</name>
        <name evidence="12" type="ORF">PHATRDRAFT_bd825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="6"/>
    <dbReference type="EMBL" id="DS999262">
        <property type="protein sequence ID" value="EEC42835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176182.1">
        <property type="nucleotide sequence ID" value="XM_002176146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N8"/>
    <dbReference type="STRING" id="556484.B7S3N8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft825"/>
    <dbReference type="GeneID" id="7204792"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd825"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N8"/>
    <dbReference type="OMA" id="PAVNCTM"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002860945" description="fructose-bisphosphate aldolase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC42835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="402" mass="43580" checksum="C3F2E4104DC4FF02" modified="2009-02-10" version="1">MKLSTAALFFIPAVVAFAPPQAAFRSNPALFATETAAEKTTFSKMPASVKPGVVTGKALVDLLQHAKKEGFAIPGVNIVGTNSINACMEAAKKYGGPIMVTFSKGGGQFIAGKAADNSDDAASIAGCVAGAKHVREVAKLYGVPVVLHTDHCQKAWLPWFDGLIEANEEYYKEHGEPLFSSHMLDLSEESLEENIGICKQYMERMAKIDLLLEFELGVTGGEEDGVDNSDVDSSRLYTQPEEVYYAYKELGSVPNAAFTCAASFGNVHGVYAPGNVELKPEILHNTQAYIQEKEGSDDSKPMLFVFHGGSGSDVKDIQYAIEAGVVKMNIDTDTQWAFWDGVREYEATNREYLQGQIGNPDGADKPNKKYYDPRMSLRAGEEAMAARLCQAAEDLKCNGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3R7</accession>
    <name>B7S3R7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_bd387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS999269">
        <property type="protein sequence ID" value="EEC42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176205.1">
        <property type="nucleotide sequence ID" value="XM_002176169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3R7"/>
    <dbReference type="STRING" id="556484.B7S3R7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft387"/>
    <dbReference type="GeneID" id="7205158"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd387"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S3R7"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051014">
        <property type="entry name" value="Cation_Transport_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085">
        <property type="entry name" value="CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085:SF5">
        <property type="entry name" value="CADMIUM_ZINC-TRANSPORTING ATPASE HMA4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="749" mass="79835" checksum="BC0DDC2EFD49581E" modified="2009-02-10" version="1" fragment="single">MDSPSRRPSLKKSSSSSKSLKPELARSVLVCNGICCAAEIPIINRILEPIKGVKKVRVNVPLKQILVDYDATQVSAKAMTKALNVENLAATIKRDGDDEQMVSEPNTYPKPAVVLSGVCWLVSMLSLAEGNLTNLKWVGLASVAFGLPAIAIKAIRTMARYQFDTNCLMLFAACGAVALQEYTEAAAVVFLFAISEWLEVRATARARHALSAIVHLRPEKANLVHPQTRQLVVIPASAVPVGALVSVKTGDKIPCDGIVVEGTTTVDESSLTGEARPIRKGLHDVVSGGTVNSGMTQIMVRTTSTSENSAVSRLIRLVEEAQANRSDTEKLVDEFAKIYTPFVVLAAVLMCSVPWAFGQETGRTWTENGLILIVVACPCAMIISTPVSYVAGLAATAQNGILIKGGAHLEALSLVKHICFDKTGTLTNGEFALLSLEDFAKNMSRKEVFEHLALMEERASHPVAQAILTGARNEKVSIPKDTELERHTIVAGEGVLGIINGREVHVGNERMFGRIGLLKDVPETVRAKVESWKGLGGTIGYMSIEGEGIVCAYCAADGVRAESASVLSRLRKCGIEVTMLTGDNRDAALAVGAQVGLSEQEIQSKLLPEEKLAFIESLSSGCTGGSILSNPCGQRRLVMMCGDGVNDAPALAAADIGVAMGAGAALAMETADVTLLDSNLEKLEYSIKMGHRVTRKIKENVAFSLTVKFVVLGFALAGLTHLWAAIASDVGAMILVTLNAMLLLPKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4K9</accession>
    <name>B7S4K9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999306">
        <property type="protein sequence ID" value="EEC42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176499.1">
        <property type="nucleotide sequence ID" value="XM_002176463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4K9"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1786"/>
    <dbReference type="GeneID" id="7204984"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1786"/>
    <dbReference type="InParanoid" id="B7S4K9"/>
    <dbReference type="OrthoDB" id="2014563at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="139" mass="14905" checksum="08F6A4236C54B737" modified="2009-02-10" version="1">MPREQTDRGGMGIAFNSGGGGGGHRKVAFALGISIWISGAILVYSLIPTWARGQRWTGTVAFAMQNLIFGLASCYLQPYKETDCTIIRASGVALTSRAAADTANLTVVSLVEFEFFSSLIIKRHEPTTLAQAFPDGFQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0J1</accession>
    <name>RK5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL5c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>50S ribosomal protein L5, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpl5</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; contacts the 5S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874466.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0J1"/>
    <dbReference type="SMR" id="A0T0J1"/>
    <dbReference type="STRING" id="556484.A0T0J1"/>
    <dbReference type="GeneID" id="4524668"/>
    <dbReference type="InParanoid" id="A0T0J1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_uL5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_uL5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000585">
        <property type="entry name" value="PRK00010.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000365654" description="Large ribosomal subunit protein uL5c">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="238" mass="27809" checksum="E2E320116EB50B3A" modified="2007-01-09" version="1">MLNQHSLEEIAEIHNLLGNIKQEYEIGIKPLLIKNSPKLFKNPHTVPKLKKIQINRGLGLAAQNTNLLKKNIEEFEKIAGQKPLITRSKKAIAGFKIREDMELGLSVTLRGEKMYTFLTKLLFFTFAQIRDFRGLSLRSFDKAGNYTLGLKEQLIFPEIDYDDVDQIQGFTINIILEHGSPKYRAESIDKILNGMILFKFLRFPLNDCGYYDKYEAFSDINRNWDKKRHLKRKRWSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3C4</accession>
    <name>B5Y3C4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_46653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185821.1">
        <property type="nucleotide sequence ID" value="XM_002185785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3C4"/>
    <dbReference type="PaxDb" id="2850-Phatr46653"/>
    <dbReference type="GeneID" id="7204579"/>
    <dbReference type="KEGG" id="pti:PHATR_46653"/>
    <dbReference type="eggNOG" id="ENOG502S3ZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062943_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3C4"/>
    <dbReference type="OMA" id="ILTWGTF"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48938" checksum="8B919BD4D919C5E4" modified="2008-11-25" version="1">MDAAVNGAAAVACEACGWAAALCSMLAFGTFGVPIKSKAAVSVDIDPLVFQTYKTFMCFATSWLVLLAGEPFTFTPWGIVSGLFWVPGGTATIFAVKNAGLAIGIGIGSSFIVLVSFIWGIFVFEEAVHSKTGACLAIFSMMLGLLGMSYFSSPESAEAIAADEAQDEPLAWALETTDPGDALVTNAQHSVRLCSGIRYRGLGPGGHETDDNQNSDHSSSNSNPGDPSLLVPDTRQKQLKLTERTEHLSFSDDPESDLEELYVDMDRTTTRESTETELSYVIVCGKKWQRRYLGMVAAMFCGVWGGSIMAPMKFCQSDTKGTHFLLSFSIGASIVNTGMWLVRYGYNVLHYQSCSKAYASLPSFHLHTMWLAGGLSGMLWSIGNFFSLISVFYLGQGVGYPLVQTSIIVSGLWGIFYFKEITGFERISKWLASSLLTIFGILLLGYEHVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y446</accession>
    <name>B5Y446_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_46896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185943.1">
        <property type="nucleotide sequence ID" value="XM_002185907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y446"/>
    <dbReference type="STRING" id="556484.B5Y446"/>
    <dbReference type="PaxDb" id="2850-Phatr46896"/>
    <dbReference type="GeneID" id="7204733"/>
    <dbReference type="KEGG" id="pti:PHATR_46896"/>
    <dbReference type="eggNOG" id="KOG3710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_889935_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y446"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841252" description="Fe2OG dioxygenase domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="321" mass="35558" checksum="91AAF5CDC56F9A4D" modified="2008-11-25" version="1">MGFGPGFSQLFLLLLFQTAQSWLSSSKLYGPTESIQRASTPSFSSSIVNSRLFGVSTSVPGIATDIPRLEPRHLRELSENQYVVICDFLPESLQTALRQDVQDLRQAEKFTVAKIRQDATNKLNTNIRVAESCFLGPTKLKTFPSAYRDQLYVILDQVKADLNSHFGKPLDSQLTELLYAFYPQGGFYRRHRDAIPGSASTLREYSLLLYLNKDWNEQDGGQLRLHFDSGDDELPAGEEAQCRDVLPQSGTLVLFRSNAIPHEVLDTQKERVAIIGWYNRPVASTDIGELAGVDLNPTRVALMGVAASLITVGVGMLISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4A9</accession>
    <name>B5Y4A9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_37020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185975.1">
        <property type="nucleotide sequence ID" value="XM_002185939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4A9"/>
    <dbReference type="PaxDb" id="2850-Phatr37020"/>
    <dbReference type="GeneID" id="7204765"/>
    <dbReference type="KEGG" id="pti:PHATR_37020"/>
    <dbReference type="eggNOG" id="ENOG502S7DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609009_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4A9"/>
    <dbReference type="OrthoDB" id="48357at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="544" mass="61233" checksum="5239AD4AEFD581B9" modified="2008-11-25" version="1">MPFASKRQAGYLTFSFVVLFPFARSFLLTQPKVHVAMQTESTATTDCELSFSKSDQPAPLYITIGPPCAGKTTWLQQQQRQSPDYSQVSIDDVSLDDQPDTYVPLNTEYFLTNTANSYPEELRTHCICGKSLAERIQGNDQRELRTVLQRVAGNLTESEFRNAIIGNIVGMDHCESTTSKSVQTLLVNAVERCMQDQTMVALLPQTVDLFVRERIFRRDGTHSTTGLESSEKALYACPIDRPVAWGNTNTRPSDYRMALVMAASTRRPVRFVVYSDKKARLRVLNNSEMDLADKVPQELFGLQATLPELIDRNVNRLLTSGRYVPVSVIRDMHERSLELLQKVVHGWNSLSRNHSNNSKLTAFDLDRGLARLVDFDLLADRTVVDLRTVNQPPQQQQQHQGNNLRRSSSPRPLHLSARDAGSRKRSSFDPRSRRQPPEPVRNGATHSRGTRTDTPLTRPVDGEKYGPRSQGSDANLAQGKRSYGGYNRGSPANSNHAGRPPQNQGDGERPRLHDQRQPSANNTRRSTFPNKTNGAPPKRRRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4E2</accession>
    <name>B5Y4E2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185996.1">
        <property type="nucleotide sequence ID" value="XM_002185960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4E2"/>
    <dbReference type="PaxDb" id="2850-Phatr33118"/>
    <dbReference type="GeneID" id="7204252"/>
    <dbReference type="KEGG" id="pti:PHATR_33118"/>
    <dbReference type="eggNOG" id="ENOG502SI74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720550_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4E2"/>
    <dbReference type="OrthoDB" id="198798at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42150" checksum="97D003F1E89E0D15" modified="2008-11-25" version="1">MNSTLPATDSDHPHVSVIVVGSGAPLQSMGWYHAVQLLDGRIPSAQLDHVVEPWWTCDEARGTLEYTAFADWQQTLQQRPGGGVQCWSHVADVPESTTPNVPRLVILSARTSENPRLLAECLRHLDCRAIFLEKPGAPTVRELQLMQTQAAAAGVKVYLGFNKNVSAYLTQTRLFAEHADEPVDVTFLHNNAYPNEPAALAECFERNAEGMLKNMAIHELAILATFYDVTVDNIASVHVDREFSLCQTLIGPSTGQSYTDFVKLRFRIVTWNGKSASIAADRCGGDDSVGIVTNSHATELARFIMPDADALAQIPMLAARYPGARPYFFTQDPDYRTLKERVVQYCLDGTPPHGVADLDIAITALQLAEYLTPILQAQLAESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4F9</accession>
    <name>B5Y4F9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_43824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186004.1">
        <property type="nucleotide sequence ID" value="XM_002185968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4F9"/>
    <dbReference type="PaxDb" id="2850-Phatr43824"/>
    <dbReference type="GeneID" id="7203957"/>
    <dbReference type="KEGG" id="pti:PHATR_43824"/>
    <dbReference type="eggNOG" id="ENOG502SUSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609017_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4F9"/>
    <dbReference type="OrthoDB" id="48529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="446" mass="50679" checksum="799ADC405AD9AC1C" modified="2008-11-25" version="1">MYTMRACMSIFVLATIALSSIGILVSMDVVLNMQSFEDKASLLHASSLPDRRSSKYGQSDTGIQNIAIEQDISAEQYPIRRASSSLPGRNFQNLSVAPETLFRKPFWSNSSSFDIDAPTILVQLGGELANQLGYIARASGLVWWLEREYGVNANVVLRRQESTTTKWIRARTDVTRCFPYLRDLDFEAGYTDEITHEISFLKEPGLQSNSTSARLIEARREGEYDETLQSFLSLYAQNHTNMGKRNGFLMTSKDLIVDKYYEDIRRIYQFDESCCIDVPDTDESVFHFRNFVTEGARIGNRLNFKELAPDQVANELFAHLNPGDKVAITSRYPDDFRTRMIVEAFEKRNIRVRVVGPRSGVADFCFLMHAQKELVGTAMSSFLIWAGLLGNATKVRAYTAMMSTGNSIFNHYNYTHPELKSRFRFERYAANMSASDLVLSKKQNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4J6</accession>
    <name>B5Y4J6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186022.1">
        <property type="nucleotide sequence ID" value="XM_002185986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4J6"/>
    <dbReference type="PaxDb" id="2850-Phatr43855"/>
    <dbReference type="GeneID" id="7203975"/>
    <dbReference type="KEGG" id="pti:PHATR_43855"/>
    <dbReference type="eggNOG" id="ENOG502SYEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884182_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4J6"/>
    <dbReference type="OrthoDB" id="44380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="307" mass="33504" checksum="430B199AF00E0298" modified="2008-11-25" version="1">MSRTWNVNMQSTRRGFHTSFVFLVGLRACLLSSLRSTILVQGLLLVVPDAMHRRKSWSHSHRAVVIRSILQLERLSFRFPKISNTVIKLSADSGDSYASTVTASSNDETKASVPSLLPSLTESVSSPMKISSSEQAANDMSFNPTIVGPSSTSVQTMLTAETKRVLIEESGYRRRDVERMRVELAGPIIEQRIRSPPGNKEMPEAWLDPDLPIASTPSNDRMLQQLQSESRFPLKFPLLGISAILFGKGLSDALITLIKVNQGFPGATLTKVFVGGIPVLAIDALCVLAGASLGAWAWTAMRDAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Q2</accession>
    <name>B5Y4Q2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186050.1">
        <property type="nucleotide sequence ID" value="XM_002186014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Q2"/>
    <dbReference type="STRING" id="556484.B5Y4Q2"/>
    <dbReference type="PaxDb" id="2850-Phatr33231"/>
    <dbReference type="GeneID" id="7204308"/>
    <dbReference type="KEGG" id="pti:PHATR_33231"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311357_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Q2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="102217" checksum="9D025EC4A10F365C" modified="2008-11-25" version="1">MTRTKRQATPSVSKNWAMIKAQLLNKAHSPVGSISRPQWNQLVEALHNLKAPLGKNLYRALVEAFALLDRMHEEVTEKKSAMPRLPLPLPTVLLHLTIDSWRRQAAEFATKGKVFPISAKSLLQKVEHFTETGLFDPSAKTYGMLVEGMASTEDKHNAPILAEELLERMTKQYGQDPAGRKLECAPNTVIVNSIINLWIKSGRSDSMDAIERKFQKLKDWYRFSGRDDQKPNAYTYSSLISALGRCGHHQAVERAETLLREYEASTGKQPCTVLYTSFCQTLATTNAPGAADRAQAVLNEMLFRSRHGEDMARPNSYTILAVVSTYLKEGRIDEAEVLVRNMEDLSRQRADDGLRPGIFCYNSLIHACAKNGNAEHAESILNHLLDSAESGNSILQPNIVTWNNVLHAWAKSKHPARAQRASNVFKRMRLLDRAGISGASADTRTLNILIDCYVNSPNPKAFVHQSIELFESVKSQGVDSSSGIFDPVSYRGMMDLLCKAGEFDRALRLHKRYIEKSTAPEAPLQPDRAYFNVLMSGLARSGWEKAVESVEAMLTEMHSLAKLGYNTHPDVVSYNSLLNCFATSSQVNAPSKAFSALRRMEQLWANGDLSAAPDASSYSAVCATWANAGLAEGAEKAEEVLRHMLLHRDQKIQSTSQVFNTVMVAYARQGDAPKVQKLFDEWLETDNTYDSRIYVTLLQAWSKAGNPESTASVLYELIRLFDSAAIRNPPTTQMFNAVLQAWLRSGRKHAEVQIKAGVDEMSSLATSGRFPCAPDALTYSTLFSACVRSGRDDLGELAHNGLLELKSRFVTTRNPMYRPDLRIFAEAIMLVAMDDKYSTKDILSQLLLELNAVNGTIWKKQGQIAMNRILAAISRSTINEKEVLAQLGVEIMRAQNVSPDESTRKFLARCCNKEGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP35</accession>
    <name>B7FP35_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177147.1">
        <property type="nucleotide sequence ID" value="XM_002177111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP35"/>
    <dbReference type="PaxDb" id="2850-Phatr42659"/>
    <dbReference type="GeneID" id="7196320"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42659"/>
    <dbReference type="eggNOG" id="ENOG502RSUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_0_1"/>
    <dbReference type="InParanoid" id="B7FP35"/>
    <dbReference type="OMA" id="SSNAWVK"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF45">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852483" description="NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="29609" checksum="F7FF6E9F44485982" modified="2009-02-10" version="1">MVRVFSAVALLATCCGAFQQSSFLGRQSLSVLSHLSDSALCMKTIAVFGASGLTASECVYQALKNGDNVVGLTRNPSNLVIPKGSGGSNAENPLNDPKLTMISGDVTKQADVDKVFAQKIDGVIVALGGKTSDVGETMLTDGTTNIINAMKDKGVKRLAVVTSIGAGDSENQAPFFFKVLMWTAMKKIFLDKNAQEEVVKRSGLEWCIVRPGGLTVEPPTGIINVIEGEAGSIARADVAQFCLDALEVEDFPYIGKAPCISSVGGTGWTKDRSAAARGQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPE0</accession>
    <name>B7FPE0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_9266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176695.1">
        <property type="nucleotide sequence ID" value="XM_002176659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPE0"/>
    <dbReference type="STRING" id="556484.B7FPE0"/>
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    <dbReference type="GeneID" id="7196375"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9266"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="B7FPE0"/>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="224" mass="23847" checksum="6ABCB1BB0B3A4EA6" modified="2009-02-10" version="1">MPKVVILVTAAPDLNGHKTGLWLEECAAPYYIFKDKGYEVVLASPSAGPVPIDQVSVSDDFFTDDSKKFLHDAEAVGALSHSVELGSIDMSTVDCIYLAGGHGACVDFINNPSVTKAVQAIYAANKTVASVCHGVIALADCHQLDGTPLVKGRKVTGFSNSEEEAVELTEVVPYLLESKLKEQGCEYEKGENWSSKVCVDGNLITGQNPQSSAEVARTIVEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPK3</accession>
    <name>B7FPK3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_17519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002176693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPK3"/>
    <dbReference type="FunCoup" id="B7FPK3">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPK3"/>
    <dbReference type="PaxDb" id="2850-Phatr17519"/>
    <dbReference type="GeneID" id="7196159"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17519"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="InParanoid" id="B7FPK3"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="186964at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16183" checksum="A558DBB162CFFF1B" modified="2009-02-10" version="1">MPEVQSVQVFGKKKTATAVAFAKQGRGLIKVNGQPIELIQPESLRLKVFEPVLIVGQEKFSNIDIRIRVKGGGITAQIYAIRAAIAKSIVAYHAKYVDEQSKNELRKTLMEYDRNMLVSDPRRCEPKKYGGRSARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPS7</accession>
    <name>B7FPS7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176763.1">
        <property type="nucleotide sequence ID" value="XM_002176727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPS7"/>
    <dbReference type="PaxDb" id="2850-Phatr42851"/>
    <dbReference type="GeneID" id="7196503"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42851"/>
    <dbReference type="eggNOG" id="ENOG502QY9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_964611_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPS7"/>
    <dbReference type="OrthoDB" id="47002at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="286" mass="32361" checksum="25B02D3D9B6DB5D1" modified="2009-02-10" version="1">MKNLVSKSESLDKTSNVLVDYKSVDYRGFVFVVHHAHGMMLLRCTRKKNKPHHWQLPGGHIDKTEFVEAARANFVHNTQLLEAGKRGAARELFEETGIDVRSQLHRMEPATLREPKDGESELANEYKHRLFYILNVANDDFLSHGETPMGTLGETLKPEPEVAADMLKLHSGGKVSAALLMAMGRSIVHEKSTDRNKSAATTLSQHHDDLSLHTLFQYGLRFLFALPQCKFLKLLDTNASAELLNDLHRSSLKYDEDPSPGLFESPSIRVRTDVARKKLQKQSMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRC5</accession>
    <name>B7FRC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176523.1">
        <property type="nucleotide sequence ID" value="XM_002176487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRC5"/>
    <dbReference type="STRING" id="556484.B7FRC5"/>
    <dbReference type="PaxDb" id="2850-Phatr42451"/>
    <dbReference type="GeneID" id="7196655"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42451"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408550_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRC5"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76569" checksum="626A429FD7507492" modified="2009-02-10" version="1">MIYERSLTMSQPQSWESITGFAASLVNTANELFSGGDEAEALLMFESAHHVLRTPSAEVLAVAAKQYQLSTDRLHNNESDRSKDGPICPADLYQEDECDVGPRLLRSPIRLDGIYPLHSEAAIVETAIVFNKALAQQIGNDENSAKQNYQLVLMSLRSFLSRLAPSLPPTLLLELGMRAHNNMGLLSYAKGDEDAATSLFQAALVFAKQLSEISKAYSLEYVTVLSNWCRVSWMRGDINDNLYKGLREVLRLRSANLCWDHPDVAAAHYNLAVAEYARQREEEATLHLRQYLHVASHRSETGQHDVDPIPALIHLLLLQNEEKDDSISQDLVRGLRTLQDKRQDQGPRSSDVASVLNFIGTLLFHKQDFENALLFFEEELRLEETMQECTDDISVAVTCNNIGRILQELGRHPEAVHFYKRALENRIRRLWYNLGLIHDRLGAYIDAISSFQMSLELRKTMLGRDHPDIACLLYNIGVLQMEQQQLSEASFSFREALRIRCVGTTGQLNDRHVIKTLEKLSSLQRAKGNINGALEASREVLRIQEVTAEYDHVTRLKDTGVTLRSIAELQHAIGNLDCALEASMESARKLEAANSARYSQDETMNSKSVSDSFVYTEHQVSSLLLVGSLHHELGEPMHALRVFEEALLLMEEADARRLVPSSHALREVTCMLARSHCAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRQ6</accession>
    <name>B7FRQ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177087.1">
        <property type="nucleotide sequence ID" value="XM_002177051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRQ6"/>
    <dbReference type="STRING" id="556484.B7FRQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr42561"/>
    <dbReference type="GeneID" id="7196098"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42561"/>
    <dbReference type="eggNOG" id="ENOG502RRBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527322_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRQ6"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65650" checksum="1FA24EB70E64C02A" modified="2009-02-10" version="1">MIELTIAISLETFYKSQRLRNLQFKWLLFFFVFGCFYKRETEALSTNDYQRYVEYPEYCSTPEQMNQRRILPVRQDNRVGETRLVSVTAIIRHGARTSLGHHTCWEGYWTTAETSVWDCEITTRITTAPPNTVSKEEGLQIAGGREIFLFDKKYDSLRKPDGTTSNILNGTCQAGQLLRKGYDQSYRNGQILREAYLYDDGASPIQHNAQMRLFPTKIEKATAMIRFRSDDDQRTLMSGQALILGLLEESTFSPLVQIHLADRGRDILSINKDICPRLTELGETSQNSREYLSFASSDEAALMHQFMNESFGRILDHPLACLMTTICNDFSLPNVFDDYPLQNEKVQLHRNDTNAKLGGKYGLNRFQRLFQYDVQNVMTPLQSDNAALLKLAMGPLWAEILDLIRAVTEDSRSKTDGQAPRFHLVSAHDTTVSALLSTLGGAVWNVTDWPPYAAMVVLEVHEIVGGRTNQNIFSSDFAFRLLYNGRVLTTTVPGCDPHADLCDITVLYNILHPFASRSRDCAPRNSPKHPWQEHISRGLHTRGIGTVLVSVTLAGILTGSILACWIVACPCPYLRHGSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRX7</accession>
    <name>B7FRX7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_32535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177574.1">
        <property type="nucleotide sequence ID" value="XM_002177538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRX7"/>
    <dbReference type="PaxDb" id="2850-Phatr32535"/>
    <dbReference type="GeneID" id="7197394"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32535"/>
    <dbReference type="eggNOG" id="ENOG502S2UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_22_1_1"/>
    <dbReference type="InParanoid" id="B7FRX7"/>
    <dbReference type="OMA" id="WMACWIA"/>
    <dbReference type="OrthoDB" id="2017960at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF5">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="296"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="370" mass="39514" checksum="87DB858E3F37C985" modified="2009-02-10" version="1">MSKDTDRERRSGLLVLLTVPVAWGTFEPAVRYLYTIDPPIPGFVFSTCYYLVASSSLYLACFLSQTKKSDGNKSLEVSQPWPIQGGLELGSYLFVGNALQVIGLQTVPSDRAAFLLQLTTIFVPLLDATLARNLYAIPGRTWMACWIALAGVATMGLDRSNTSNSFQNLEPSLGILNDVLSQLSGGDAFIVAAAIAYTFHCLRLESYAQSTSAVQLAASKATTETVLSAASVAGLIWYSSSTGYDKLSVEELKTHSDHLNSLASFARQTGQEIVNFLSSVENGIASGSVSFATLRPALLATLWIGLVTVAYTIYAQSYGQSRIRPVTANLIYTIQPICTALFAWFLLGESLGPAGYAGGALIGAAVLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSI9</accession>
    <name>B7FSI9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177990.1">
        <property type="nucleotide sequence ID" value="XM_002177954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSI9"/>
    <dbReference type="PaxDb" id="2850-Phatr43528"/>
    <dbReference type="GeneID" id="7197566"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43528"/>
    <dbReference type="eggNOG" id="ENOG502SPIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FSI9"/>
    <dbReference type="OrthoDB" id="43960at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855274" evidence="2">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="41853" checksum="75B20F419CE33668" modified="2009-02-10" version="1">MSFPTGVLLAMALVTLVQSFTVRTMHRSRCLLPRQRKVAVVAVQKDSADKELSIDWDGGGKLQGAENEKSPRSSGMEDDLGNIQIPSTGISVSDEIEASQKDRFVTEVVPVKDLPGVAQLVTSATVMGSFEPVRYLVSLSPPKAQNVGDDEQTFKEECLTFAMVDVPPFSRQLVTRMKAYMGVNSKLKVILVTSRNAIHYDEAVTIYSTRRADLDLWAQTFSGVEIVSYRLDTPRDCRAAVTQCLDGYGPFALDEKTHPGNVTFVESGRPLTRLEWDHDVAQEVLSGQTPPDDEMEVDDEYSLDSIRIKEEGSRILAIFTPGHSFGSVSYVFPETKWKTHAQKRIGASAELAQLWIVVDISRQTVPESIDKWNRPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSQ9</accession>
    <name>B7FSQ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_32823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178025.1">
        <property type="nucleotide sequence ID" value="XM_002177989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSQ9"/>
    <dbReference type="STRING" id="556484.B7FSQ9"/>
    <dbReference type="PaxDb" id="2850-Phatr32823"/>
    <dbReference type="GeneID" id="7197462"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32823"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="B7FSQ9"/>
    <dbReference type="OMA" id="STIYPCQ"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="25047" checksum="6F29EE18C25C10BC" modified="2009-02-10" version="1">MSSSRPFPCDEVIARKKELRKEIRSKLKALSKEEIRAQSVRVWDRLFELPQYRQARSIGLFLSMPTGEISTELALKNASENEKQVYVPQVGKNFEQADMELIKVVKDDGIKQGELFYHSWPLNKWGIPEPPPHIPLIPAAPGDIDVIVVPGLAFDEKGNRLGQGKGYYDRFIARMTLGEGVSAPFLVAVGLECQLTDRVPVEEYDQLMDLVLLPSQTIVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSS3</accession>
    <name>B7FSS3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178031.1">
        <property type="nucleotide sequence ID" value="XM_002177995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSS3"/>
    <dbReference type="STRING" id="556484.B7FSS3"/>
    <dbReference type="PaxDb" id="2850-Phatr43595"/>
    <dbReference type="GeneID" id="7197470"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43595"/>
    <dbReference type="eggNOG" id="ENOG502S0TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568009_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSS3"/>
    <dbReference type="OrthoDB" id="70932at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="54088" checksum="C6594A82628C88D7" modified="2009-02-10" version="1">MSPRRSVVLGSTLTTIFVSIVNMVSALTESFLFEQRNVSRRPAGETKTVRWMVDLPEETSSAALLQSSCDRLPASQMARSIRKYRSSRGRTDSDEAASTDCFTQTRDQHGSGSRKKSGPRDQPKTDDLLRRRSGVDLPYYSAIKALRAYSSLHGNLVIPRRYRVPYTKDYANEWHGVDLSTIYDMKWWQRNVKSKPDRVAELNQLGFVWERLQPEWNLILEALITYRTLYGNLLVPSSYVVPQGDNRWSKATWKIPLGNCVYRIRSRSDFLRDDNAGSRRDQLDGLGFVWDAQERRYRIFYAALRHYAKLEKCGAFSVGRSISISIPSNYIVPSEDLWPNELWGYPLGAKCIAVRQKDLYVKDKPERKQMLQKLGFHWGGNADLGWLRVVHAAAIYSRMHDRYLDVPYHFKVPAPSTTEHDGQEWPWPEHLWGLPLGQRLKDVRTKDTRDHALCASTGRFCSDPPFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSV4</accession>
    <name>B7FSV4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178046.1">
        <property type="nucleotide sequence ID" value="XM_002178010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSV4"/>
    <dbReference type="PaxDb" id="2850-Phatr32869"/>
    <dbReference type="GeneID" id="7197486"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32869"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FSV4"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="13022" checksum="6001F5204ECC8671" modified="2009-02-10" version="1">MSAISSRPLVSTLGESKQDTSEYGFPDMSLLDITEGENERKIPIAKFIDDVGAFCSSFTPVPASAELLIGAYTELHAKYKSFEVSLTNKRNFDALHNNAASRCILTTLDVGFDRISKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTH6</accession>
    <name>B7FTH6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178152.1">
        <property type="nucleotide sequence ID" value="XM_002178116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTH6"/>
    <dbReference type="PaxDb" id="2850-Phatr44259"/>
    <dbReference type="GeneID" id="7197940"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44259"/>
    <dbReference type="HOGENOM" id="CLU_381974_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTH6"/>
    <dbReference type="OrthoDB" id="10513302at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="725" mass="83273" checksum="842769DDD92AE4E2" modified="2009-02-10" version="1">MGFFQIQVPFKNDLDNKSQSSFATVKGAARSYKDVWYRRFLKPLSKKDSRVSNRDVFRRRAFYSSGIPVAELEGFHEFFEPSYRRYSPLYGLLFSYNNMVDNLYRYGNADAEPAVALIRSLFHQLPGGDVQPTHLGSEPGAHLSASIIGLLIEKFESLKHRLEEMPHQEAMAFLVNELLQQTVNHPDYQLERKELIEDSVKAQQNLNHLRRRDEESQPVRDEIKMLEGDVIKASRHKVKRLKKQLEKFKDKQAIQKTISEIEITMKSAEKKVADLRSQIVTSLDFKLARKNLQRAEQMVEQEKSGREAYVTALASSFLRYDLESANPSCLPKYTTAAVLLAYMWRKYDGIHFLEEYFEVMERMGVLIRPAGERGDLLKQESDCTLDSSVRKLPRVQEWSAGDTEAAAIVVIGQPGVIRRPTIVPFSYITWAAYSEFPDCGETALRNFLNQLLYNPNTGMFDHGLLKLLRAAYYPNMNPKLLQFYQRHVSPQDSTSQETAVEWIDTTTGLNDGRDGDVLIRYRREKQQTNIASPLKNLLRVFNALFGIEPLDKESLPEVIDHMNELRDTRLRVDMARVRDDGFGVVSLSDGKVRYELQSYKPVHFGFVQAETLRSDAAGKQVYGIFRKLKKYSCGIPHVAFDKQAYFEQLALASLFVPYQLNSGRIKPFFRVAPAHYMLLFADMTGPAQRLAAVEWAKGRESNDQLEAFIKGIESYQEPDFMPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTH7</accession>
    <name>B7FTH7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178418.1">
        <property type="nucleotide sequence ID" value="XM_002178382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTH7"/>
    <dbReference type="PaxDb" id="2850-Phatr44260"/>
    <dbReference type="GeneID" id="7197986"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44260"/>
    <dbReference type="HOGENOM" id="CLU_753291_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTH7"/>
    <dbReference type="OrthoDB" id="47587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="41616" checksum="B4408CFB5EF4EB1A" modified="2009-02-10" version="1">MFLDFHVGVTPWRETWIARRQKRVKGVWDGALERQFIVLRDQRRLTFFLDGPILSTPYSPRENDVNGQTCENRRNVPYIFCFHAMFLSGNNFLLTDPPEDYVLVCINRPGYFGSDPAPPTYTYETFADDVKELADYLRIDCFSVAGHSSGGPCALACAAHIGPKRIVSVGILSGDPEYAHEGIPNKSDRNAFLLGKFLPNLLLFLPCIPLCRQARLGLINDYRLETSSYSFRTEDVLQPALVYVGEDDQVMPLEVSRHVHERLDNSTYRIVPNIGHMGLLRDEVRDAMSLSVRALPQSLSQTVSRRHTTVLEDFFENLLALADHNLEPADEVVEPLTPSRILDDVMDIELVSSTNPSSRSSQVHHRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTI1</accession>
    <name>B7FTI1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_33661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178155.1">
        <property type="nucleotide sequence ID" value="XM_002178119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTI1"/>
    <dbReference type="PaxDb" id="2850-Phatr33661"/>
    <dbReference type="GeneID" id="7197988"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33661"/>
    <dbReference type="HOGENOM" id="CLU_798023_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTI1"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="348" mass="38797" checksum="9AB589987EC33D7E" modified="2009-02-10" version="1">MTQSASAFRTRRRTLAKLPGMRCPEFLDTRDSWLGFTKSQSRVSKKVANSRAKKNRTTTRIAHTRTTAQRQAEPSILAPSRDCCASTSTGTDKQNVLKIPKESARSMDSAKVKELLQSTDISLLKDTLRVYQDVNPEEDARQQEQLLKLQILLWSRILHLQQNDPNCNPLDIVESYHHLSRCWMSMGDTTKAIGQLRHALAVQADNCQTLQLLSDAHLSSADYESAIDWQEKAINGMQERRKDGASVCFAYGNLGAIFEAKGDFEQAIAVLQKGQSFWPSDNNVALPTGEAADLAVRLGMLLEKMGQYTKAVQELTVAHKMLVHLKGEGDAQAEEVAYLLDMASNMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTY8</accession>
    <name>B7FTY8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178507.1">
        <property type="nucleotide sequence ID" value="XM_002178471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTY8"/>
    <dbReference type="PaxDb" id="2850-Phatr44398"/>
    <dbReference type="GeneID" id="7198058"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44398"/>
    <dbReference type="eggNOG" id="ENOG502RAVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367049_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTY8"/>
    <dbReference type="OMA" id="VYKSHKC"/>
    <dbReference type="OrthoDB" id="38405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="84589" checksum="148E390196D37A66" modified="2009-02-10" version="1">MTLTVCVGSSGSGKTTFLEDVYKSHKCIYIRQYHIMRPYITVSKIPNFDATRLPYWDIYVKEEKAEKIQVGGTMAGEFTAGLSGGQRKLLLFELICQRTASQSELLVVLDEPFAGVTDDFVPFIVERLNELRQKHNVLLVTNDHVTTLTTMADNKITVSAIDRSTVRINDREKVDREKAIMALSVGDAYSYQATNADLKFFYDVEIHSSSALIGIACFTIFCYSLFIATFWDSEESSQALVLVAGGIISYFCVNPYLLSLVDWRNAQNEEAEALVHASKTMNKTLKTLLTFSLILIISLIEFGVVNATIDGLSEIKFWVAMLFDSASLTFTLICLGLYTNMPFQAVQVVGSLPFLLMIFLSTTFSPGSGVPVLKELRYLYARFYFWCMVPAVQDTMENCPSDNVILVYVILSGCLGVFIFLVVMAILKIKRGIQKDKAETKRAGLRDDEFTELQVELYGTKALHRLMHMNSSLSLKKPASNGTIKEAIGKSVGRAFILILLWCKRLTVSSAFKHAAPSRVTGDAQGADKVFSLDVTLRSVLLSKRSAKMRCLMVGSSLIALLVDNAAALNIVLPGGTGSIGSRLSAKLMDHTVTILTRNAFLAAAPNRVTEQFGWVGSSFLRKNPHVNLRDWDGGDLLDIVGQDWIGWQEEALLDADVVVHFVGGFTEQRTMACERLVRESMRVNKDALQITVNPLDEEIGVISVGAVTQKKERIRACEEMVKMNCVHSMCLRIECYREDEGCEKIKSTIVDWAKRQGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUM4</accession>
    <name>B7FUM4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CaMK2</name>
        <name evidence="17" type="ORF">PHATRDRAFT_54265</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178623.1">
        <property type="nucleotide sequence ID" value="XM_002178587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUM4"/>
    <dbReference type="SMR" id="B7FUM4"/>
    <dbReference type="STRING" id="556484.B7FUM4"/>
    <dbReference type="PaxDb" id="2850-Phatr54265"/>
    <dbReference type="GeneID" id="7198099"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54265"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453073_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUM4"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC50288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="325" mass="37009" checksum="787D64A8865B068E" modified="2009-02-10" version="1">MRFDELYRLKGVLGTGAFSTVREGFHRNNQKLSYAVKCINRKKLTEEDEAALLDEVSILKEMEHSHIIRLYDFFEEPSTYYLVMERMRGGELFDRIVAKAYYNEKEARDTCKIVLEAVGYCHQNHVAHRDLKPENLLLLSEHDDSAVKIADFGFAKKVYKHNCLTTQCGTPGYVAPEILEGTPYDERADMWSVGVILYILLGGYPPFIESTQRDLFRKIRKGEYEFHEEYWGTVSTEAKDLISSLLTVDCSTRLTAHQALENGWILGDDAKLASKDLGPNLKKLANFNAKRKLRAAVSAVIAMNKLNFLSESFVKPGGKMTKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUT7</accession>
    <name>B7FUT7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Demethylmenaquinone methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178654.1">
        <property type="nucleotide sequence ID" value="XM_002178618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUT7"/>
    <dbReference type="STRING" id="556484.B7FUT7"/>
    <dbReference type="PaxDb" id="2850-Phatr44651"/>
    <dbReference type="GeneID" id="7197644"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44651"/>
    <dbReference type="eggNOG" id="ENOG502QV18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807683_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUT7"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29656" checksum="CEB6C0D08FF9C6AE" modified="2009-02-10" version="1">MLTSARTFLSRSGISNVAARSFAQGPASGGSISDDLLQKLGSLSTQALVDGLWVMGWPSAQIDGARPLSASMKCVGRAVTLNFVPARPDIAQDKPAGGQSPEYEAFELCGPNEVLVMASVGPWESVGGDIKFLRLKQRAIGGLVTDGSVRDTDEIINYGFPCFAYSTTARQGPAAMQPWECNGVLNISGITVRPGDAIVGDQDGVVCVPAKVAETVYNIAHGREVIEGIVKEELVKNPGPPGKFYPFMSGKIKPESPLGQLLASKGITPENSNQFEGTADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUV1</accession>
    <name>B7FUV1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_44665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178384.1">
        <property type="nucleotide sequence ID" value="XM_002178348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUV1"/>
    <dbReference type="PaxDb" id="2850-Phatr44665"/>
    <dbReference type="GeneID" id="7197651"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44665"/>
    <dbReference type="eggNOG" id="ENOG502S5YA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035002_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUV1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="297"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="522" mass="56629" checksum="80242373FFB46ADF" modified="2009-02-10" version="1">MAVQIFNETKASTRLHFVATFGLAKALANAMSGSLADTLGRKPVLILGCLVGLPVMPYVIVANSWSGVTLMNVLFGLSQGLLGSSLFFLLIDLMGSRRRGIAVGMGESTIYVSTAIVNVLAGRLASVYGFRPVPFYVATSISVLGLLSTIPLQDTLDQVRAEQTESERINRKKYARLLSTQPSKLDEERIDTPNCTDRSRLDTTNCGIGETYGSVDEGYVSPWRMSTHTLDTTDKEAVKENDGDMETQPMTAFSFATSCYVSTSRRDQRTSSGPLRSVKMLKSPETSLSSLLLKNRSYVALCFGGMSLNFKDGFCWGSFPVFFKHEHGLSDVRTDWLIAIYPLCWGSAQAFTGALSDRFGRKSFLVAGVGCCAVSMVIYVLPSYCWGVAAGSKHFHVWVAADVLLGFGTALAYPALQAGAADEVDPAYRGLALGFYRFSRDMGYVLGAIVCGPLTDAIGYEDTFLVNGTVLCLAFILLLVFYSDDQSEQTFEFSTATDATFKPSPFTAGKSRILTAGISDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUZ5</accession>
    <name>B7FUZ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_44703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178682.1">
        <property type="nucleotide sequence ID" value="XM_002178646.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUZ5"/>
    <dbReference type="PaxDb" id="2850-Phatr44703"/>
    <dbReference type="GeneID" id="7197930"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44703"/>
    <dbReference type="eggNOG" id="KOG2325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251199_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUZ5"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1275"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1307"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1386"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="2"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1453" mass="159038" checksum="AF5588774A04D2BA" modified="2009-02-10" version="1">MVGFGSSLRIARRSGWEGAYLDYETLKLLLSQIEAVYEEETHRQTSHEWNVLGEQETARDYREELFLESDSDEEYASLEDDVDINDNDDLSAGMGAADESGQNVDFSMGTSSRSSKPFKLSYSHEATSSDEEEDQVDVGCGAGTLSSWTPRTWDTSNITRKKPPYQQQGGNAAKRKAHRLPRLREDDDFYASAGGSGHAIGGSGVRSGIGTLPSHGTTLTNNTATQAFYMAGGSGSDSAEYLQTLGSSHTPSILNAPIRRTGESASLLPPTTPSQSNASWYTFHTSPSVRTSHNMDNTTPPHVTSADFLRDNHLLPESINLTPPLSGRMNHRGEDERNRDRVARRKRRHRLRAIRKQKERKVPRHIRVAHSKARAITERFLGLLRAETEKVMLFAQSRLGELADTAGSLRFPSIDEIDYVPHQTQGSAAYDYRLTDGGMHPSASSSEDDGPAGACPWSDSSDEEDATTANNGRASPREGSYIIPKGHLSEETLGRANPSASKSVASSAKQLKRAAKIKESKGQRNVKQHAETLSSVQRQIAHFARLRKNRPVFQRNDQILGEDMLLISAVEEADGFTAVGVELMHVLRYICVNLIAVRKICRKHDRLLMNRMLGGYYHRTRNLGHDRYAHIEDVQTLGGLLARVSGDIYEAHPALIGHMTYYKLVGVYDRKVQKLANSRTVQVISACLALALSEHEITQSRAEKLTKIQSTTSSDTPKRSGHGGTLSWVQGLKNSLFQPAVKSDDEEDDGPPSTTSTVSLTRLRFTVTSIFALREAARYKMDHYATYLSRSLISFTGQPAAGEGLDGCSRVTLDFLVSYNPDAALLFDSSVLYNGIKHGLWLGEPVSEVMVSTLAAATSPDPAFLLNGSSTLSPEELAVANAVSIVPGPKNLFLQSFLKGLLPKQLAVKGSPNISEAPLKILRLSQFSCFLYSMNYFVAHSSTNTFTHAMGAHSAYSSVIIGIPNVAAIIVAVIHVQAVASEKTAGRFPRDSTGLLRGCFLVSAIMGVLGNIAHSLAIEKECLALAICGRFLLGFSSAEILHRQLLSTCLPAYIVSESSMLVQLRAVGTVLGLIAGTIIESLPISFDALGIRVLQTSGWLMAVLWMTQLINLLLSSGLVEGRMKALGCDFSVLEGQEINGPAKASSVDYSSDSSSSVEPGTPTSVLYRSSSDVTSHDPFTIAYGSQQEEQIMSDQNTASTESTPLKTFDHGIRRRPFRQITTFFARTKKLLAFHIAIPISLAILLYTSYATEVFFTATPIVVCRYFGWNGDHAGVFLGGLALLVLPTYFVCELVARRYEERTVLKRSLHVISWGLFFMINWVSICSLAGRFSSLLAERPDGPMAHPYDWKLGVFQYVIGLTFTFIGLTSLEGAAQALASKASPSRLSSVSVHVSSLAVFLSFTGRIFADGQIFFVELSHKLINVDIVNSLVVPVFLACFVGLYFVKKHYFFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV51</accession>
    <name>B7FV51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_19513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178865.1">
        <property type="nucleotide sequence ID" value="XM_002178829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV51"/>
    <dbReference type="STRING" id="556484.B7FV51"/>
    <dbReference type="PaxDb" id="2850-Phatr19513"/>
    <dbReference type="GeneID" id="7199653"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19513"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FV51"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="525"/>
            <end position="527"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="577"/>
            <end position="578"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="76481" checksum="B424A2B578154BC7" modified="2009-02-10" version="1">MPVVGVASTSSFEPINSSSYQNQSRDSDSFSALSLNNYNTCNSGRRSWIDMVREVLSIDYTPAQTDDLDALGDLEELQETSLTSREASKTIHQRRPVGVAILIFLAITAVGLVVKTKRVSPYGGSGGSVVDNQSSSVVNRFCDDPVQALKPTASIEGLKHGAVAADHPVCSKIGTSIMRDDGGNAVDAAVAVALCLGVANPASSGIGGGAFLLVHHDPVDESERVIDCREVAPAAADTDMFLDHSDPKASTVGGLAIAVPAELRGLELAHSRHGKLQWAQVVEPAMLLAVNGITVNANLAHEINIMASVVPDFGLRDLLTHDGNWENPYKEGELLKNPKLGETLRAVMAQGSDALYSGTRAAQLAKDIQEAGGIITKEDIEKFRATLRSPVVARDINGFSVVGVPPPSSGGAVIIGALRFLAGYASPLAAFSDTLSRHRFVEACKHVFAIRMSMSDPSFNPASALDTVEDLTKGGFMESLRLSTRDNSTLPFRRLARPFGYLNDHGTTHFSVVDKDGNAVSMTSSVNTYFGSHVVSPSSGIVLNNQMDDFATPGKRNYFGLKPSEENYIKPFKKPLSSMSPTMVFRTTDSESSSNTVGDLILIIGASGGPKIITAVLQVIINHLMMGMPLFDSMAYPRLHDQLIYHGSAVTTTERAVLLQGPTLMVAGRTKDALVRRGHALLDVDYAGTVQAISIDLETNELSAVCDLRKGGRPDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV90</accession>
    <name>B7FV90_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_11305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178885.1">
        <property type="nucleotide sequence ID" value="XM_002178849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV90"/>
    <dbReference type="STRING" id="556484.B7FV90"/>
    <dbReference type="PaxDb" id="2850-Phatr11305"/>
    <dbReference type="GeneID" id="7199519"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11305"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1725679_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV90"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="83" mass="9406" checksum="CDD963C077C43B89" modified="2009-02-10" version="1" fragment="single">QVAHLYRHSLRVLLSWAVDRDIFNEAATELRARFDAQRGVSAAAASRLLKEGDDELFSFTHPDPYKCVYMPGGSKFMRNPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVQ2</accession>
    <name>B7FVQ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178970.1">
        <property type="nucleotide sequence ID" value="XM_002178934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVQ2"/>
    <dbReference type="STRING" id="556484.B7FVQ2"/>
    <dbReference type="PaxDb" id="2850-Phatr44806"/>
    <dbReference type="GeneID" id="7199909"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44806"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459663_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVQ2"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03128">
        <property type="entry name" value="GAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="252"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="585" mass="64105" checksum="335CC9FED80A53FE" modified="2009-02-10" version="1" fragment="single">MPAICCCCDSSAAVAVREDFATRDTSIGNSIIDPSLTRAFMNVPPHFASSSLATADWPTEAANRLQLRAPSACKVSAEHCVLQYDTTKALLLVVTSTSTDDNRDGEQILDIIDPDDMIGVKLEIQTTDRFGAARSTSQASAQGEENTFIRATNEPTTDGLADSRGSALLTLFVYPRKDPSKPSFLNRYGVTTYKPKPDPKYARPTADTLSKLGFRHAHHRTFKLAPTEDLQDCSTVVAALRKLCSSQQPSAVSPLRYLIVVNPQSGPKRSGGKLCETQVQPMLEQAGIEVDVCITTHPNHAQERMAKSSTEEDIAGYDGLVLMGGDGVVHEAYNGLFARADKDELLKKLKIGVIGCGSCNGFSTSLAHGSHERYGIVAETFLVAKGQSCWHDTSRYQTTTKSYSSFLTFSWAIIADIDIESEVLHWLGEPRNDIWAVLRILALRRYQATFSYLPATEATADNTITIPALSDPVPSTWTTVEDGFYLFWASHVTHAAMHTYHSPNSKFQDGIFEIMIVRGRVSRYRMTRILLALESGNHVGMPGVEFVQCVAYRLVKETPGSFNDIDGEAVEDGPIQAQVQPHSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVV6</accession>
    <name>B7FVV6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_54310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178771.1">
        <property type="nucleotide sequence ID" value="XM_002178735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVV6"/>
    <dbReference type="STRING" id="556484.B7FVV6"/>
    <dbReference type="PaxDb" id="2850-Phatr54310"/>
    <dbReference type="GeneID" id="7199562"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54310"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FVV6"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="62473" checksum="DAD6B9671D1945BA" modified="2009-02-10" version="1">MLSAVAENAARKRAELGDVPKKTMNQTMYLVKWAGLGYEHCSWETKKDVNDDKLIAEFHKLNNTFPDEPDMPMEAKEAWLEFRDKLYDPNEPHSYKNGNRLRDYQVEGVNWLASTWYKKQGCILADEMGLGKTVQIVCYIEHIFRVEKVHRPFLVVVPLSTVEHWRREFEGWTDMICCIYHDRQRVWRDVLREYEWYYEDRPHTAEFLKFDVLVTTYDTLIGDFDVISQIPFRVAVVDEAHRLRNQKGRLLECMREISAKGTMQYGFQSRVLMSGTPLQNDLTELWTLLNFIEPFKFPDLDNFQLNFGNMANREQVESLQQMISPYMLRRVKEDVAKDIPAKEETVIDVELTSIQKQYYRAIFEHNHAFLNIGATRNTAPKLMNIQMELRKVCNHPFLLEGVEHRETDRQFKEFSEKGLFENKAPEEQQRLLNEHGYIMTSGKMVLLDKLLPKLKQEGHKILIFSQMVKMLDLISEYCDLRDFRYERLDGRVRGTERQKSIDRFENDPESFIFLLSTRAGGVGINLTAAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW39</accession>
    <name>B7FW39_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178817.1">
        <property type="nucleotide sequence ID" value="XM_002178781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW39"/>
    <dbReference type="PaxDb" id="2850-Phatr44917"/>
    <dbReference type="GeneID" id="7199608"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44917"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649687_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW39"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="90"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="429" mass="48135" checksum="2D181803286BF27C" modified="2009-02-10" version="1">MPLPFKMEQPKAKAQRPSNTEAADVPNSQDQMPPTNLDAASASENDIADEPNQCFTILSHHSYHDYANMNEPPILGTGVVGCATKTRGNSMNPFPLMLHKLLEGAKKGNYSEIVSWKPHGRAFHVHMKDRFVKDVMPLYFRQTRFASFQRQLNLYGFRRLTGRGPDEGAYYHELFLRGMPELSSNMVRMKVNGNEVRLGSSPRTEPNFYAMSVVHEPSTQQKQSTPKKRPAITQRTAERPSYPLDRKMLADSWKVPGDMQDAAIGSSSKISIEKPSSVDIEYLRSHLSQQRHTAFQDFSGHVVPGQKTTVAPLKDMVVNQPPLGNASDLVRQRTCPDEDFPVPEPVPLRRHDVGTEDDDQTSMVNFLSDIDLQPSSDENTLDPLRIHHSSDDSSVLKHLQFSSDESMNPIPKIPSAQQSRSSSSKEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWG9</accession>
    <name>B7FWG9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_11652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Plastid</location>
            <location evidence="4">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179383.1">
        <property type="nucleotide sequence ID" value="XM_002179347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWG9"/>
    <dbReference type="SMR" id="B7FWG9"/>
    <dbReference type="STRING" id="556484.B7FWG9"/>
    <dbReference type="PaxDb" id="2850-Phatr11652"/>
    <dbReference type="GeneID" id="7200302"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11652"/>
    <dbReference type="eggNOG" id="ENOG502QUHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_904522_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWG9"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.10:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="Translation initiation factor IF3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="6">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="21231" checksum="204E5A0EC0138CD5" modified="2009-02-10" version="1" fragment="single">MARGPPPRRGPPVQEKKPTMNGEIENRELRVVTPTPLGKDEPLGIMSRDEALAKAKEMGGLDLILVNNNSDPPVCKIVDYSKYRYQLEKKAKEVKKNSKGTEIKEVKMSYKIDVHDYSVRKKSASKFLKQGNRVKCTVMFRGREVQHDNLGFDLLNRLASELEEYCMTESKPKREGRNLSLILTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWJ3</accession>
    <name>B7FWJ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179170.1">
        <property type="nucleotide sequence ID" value="XM_002179134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWJ3"/>
    <dbReference type="PaxDb" id="2850-Phatr45124"/>
    <dbReference type="GeneID" id="7200189"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45124"/>
    <dbReference type="eggNOG" id="ENOG502S7AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616110_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWJ3"/>
    <dbReference type="OMA" id="NCICVLP"/>
    <dbReference type="OrthoDB" id="202431at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855533" description="Oxidoreductase FAD/NAD(P)-binding domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="307"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="427" mass="46537" checksum="FBF7667A2AD432EE" modified="2009-02-10" version="1">MKEGPRRRRRQSVEILYLSLVAGSSAVSAFQPLHAQSRTYPRRTSLPGPPRKRTSSVEVQMSSPGVRVPRASVRVAIDQPLISDTFFTKGAAAKATARTGILQTVTGALSAISLRTVLTTVFVALLATILVRSSSSIAETLGKTFRLVSGRVQRVWERFQRVDEGIPMPFDEKANDGWGICTLKSKERLGKSNFMQYTFDLPEPDYVLPLDLGQQISMMCLDDDGDVAQGDFFSYNLSASPKPGSFTILFPTGSHEENTCSIGSSGANFLRALKQDVKVGDEIALKPGPIKLSYRGQYLPVTGMVYIACGTGIVPVLDQVRAVLPADSSSVTSVSVVWINEEAKDFDVTAELLEKEYYKYSKKLAVSCVVDNTMQRQSLGDNTEVHAAVPDFTQGTMAVIAGPSDMAKKAIAFLENRGYPRDTICVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWX1</accession>
    <name>B7FWX1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179454.1">
        <property type="nucleotide sequence ID" value="XM_002179418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWX1"/>
    <dbReference type="STRING" id="556484.B7FWX1"/>
    <dbReference type="PaxDb" id="2850-Phatr45229"/>
    <dbReference type="GeneID" id="7200249"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45229"/>
    <dbReference type="eggNOG" id="ENOG502R8Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461922_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWX1"/>
    <dbReference type="OMA" id="IPWYRSS"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="591" mass="66020" checksum="98C9F230C8813631" modified="2009-02-10" version="1">MASIYSTPGRRSTPRHKPLPEGEIHDFCHLIENTPVDKWQIRSDAFERIVKQIPTGTAYTEGDAWYNNPPILRHLAIPISDLLKDARSTVVKRTCASLTKLFNRCQSDARYLFKDLMPTILSVHAQTVQVIRQAVQAMIEESIPEVPCKSIMPFLMERLKIDKSRTVRDACALYLGICLRSWTEEGYLTDEIWLQVARCFLASIRDPSPPVRSYAKANLAYIQSAKPDLFLYLIQDGTKDLKLQRWLESLGRNGGDGNPNEDLSVISKNSYNSDIRIRAVGSIFRSGPSQGNFPRPRQVRSEELNYRSDHDSVSGNSVPTSIAVGPSESAHQSVASRVKPLGNLGPPVRRQVAPAASFSPEPKAPLLPPSLIQVASAAPEWLHLPSDLGQQQHSQTIQTHAEATEEGPFIASMQELKRHASKRRSRSSLLMKERFRTSQSSSQLGSTLEPILVDDHDDDVTVRQIGSTQTELSNEENEVPNPPRTAESYQKSSSSATSVASFNAAPEHMAIAIRLLRAHKTHVDSIMETLRIEMDALRDFDKLLEEAGRPNEDEVLDYFESVGLCLEQRTASGSTLRREMDRISRGEPIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX26</accession>
    <name>B7FX26_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179483.1">
        <property type="nucleotide sequence ID" value="XM_002179447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX26"/>
    <dbReference type="STRING" id="556484.B7FX26"/>
    <dbReference type="PaxDb" id="2850-Phatr34920"/>
    <dbReference type="GeneID" id="7200132"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34920"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1013594_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX26"/>
    <dbReference type="OMA" id="HIHAMIG"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="275" mass="30635" checksum="C59BCA81D5E24649" modified="2009-02-10" version="1">MTTPGQNEKTKETEVSRDESCMQLSGEQLFATCPHQPSKQKIVETSESLIEGTSQLKTERARQDVSGPKVQHDSATKNRQKNDNQSARNKRDGRSFAKVLTAPTQGNTNVPLAKNSGVFMLLLVGLPGSGKTTLACRLLEEWPDKFVRINQDELGTRRECERLTRDALSAGKCPVIDRCNFDKSQRQKFVSIAKEFSADTLVYCIVLDVDRKECIDRCRRRTGHPTIKPAEATKIISMVASQYKPPKKAGVEGLNRVYKTNSTDSAIEHIHAMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXB0</accession>
    <name>B7FXB0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_11634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179307.1">
        <property type="nucleotide sequence ID" value="XM_002179271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXB0"/>
    <dbReference type="FunCoup" id="B7FXB0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXB0"/>
    <dbReference type="PaxDb" id="2850-Phatr11634"/>
    <dbReference type="GeneID" id="7199969"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11634"/>
    <dbReference type="eggNOG" id="KOG2486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536906_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXB0"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="10">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="21540" checksum="3C8AEF09DA4F1447" modified="2009-02-10" version="1" fragment="single">MQFLGSFLDKQLPPRIGVPEIAFLGRSNVGKSSLLNRLSSSARQLPTHNDQARVGKTPGATASVNLYALLDAKESQILGWVDLPGFGYAKLSKQVKESVQETAENYLARRQELVLGILLVDARRIPSNDDRAVLAALFDMGIPVVVVATKVDKLNPNELRSGLAEIRDGLGLPDGQPLPVSSVTGEGTRDLWRIILEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXN9</accession>
    <name>B7FXN9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nad-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179589.1">
        <property type="nucleotide sequence ID" value="XM_002179553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXN9"/>
    <dbReference type="STRING" id="556484.B7FXN9"/>
    <dbReference type="PaxDb" id="2850-Phatr45434"/>
    <dbReference type="GeneID" id="7200545"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45434"/>
    <dbReference type="eggNOG" id="KOG1429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_2_1"/>
    <dbReference type="InParanoid" id="B7FXN9"/>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="364" mass="40508" checksum="B328AAC3A4A2A674" modified="2009-02-10" version="1">MTMKEFTLPAGEGKKVCVGGGAGFIGSHIARRLKAVGYYVVVVDWKKNEFMENSEFCDEFILGDLRKLEVACSACEGCAQVYNLAADMGGMGFIVSNESVLAFNNTAISMNMLEAARRNKVKDFFYSSSACVYNEAKQEDPANPGLIEADAWPARPQDMYGLEKLYAEEMALAYGRDFDMNVRIARFHNIYGPRGTWKGGREKAPAAFCRKAITSTEHFEMWGDGKQTRSFTYIDDCVEGVLRLMFSDCDVPINLGSTEMVDMIEFAQIALSFEAKKLPIKHIEGPMGVRGRNSNNKLIMEKLGWEPTMQIKDGLRLTYFWIKEQIDAEGGDGAAYSTSEIVQQVDDTLMQLGNEKSTAIDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXS0</accession>
    <name>B7FXS0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_52684</name>
        <name evidence="5" type="ORF">PHATRDRAFT_54412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179606.1">
        <property type="nucleotide sequence ID" value="XM_002179570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185193.1">
        <property type="nucleotide sequence ID" value="XM_002185157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXS0"/>
    <dbReference type="STRING" id="556484.B7FXS0"/>
    <dbReference type="PaxDb" id="2850-Phatr52684"/>
    <dbReference type="GeneID" id="7199005"/>
    <dbReference type="GeneID" id="7200562"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52684"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54412"/>
    <dbReference type="eggNOG" id="ENOG502S0IG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXS0"/>
    <dbReference type="OrthoDB" id="10062183at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033503">
        <property type="entry name" value="LarB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064:SF1">
        <property type="entry name" value="SLL1489 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="3">
        <location>
            <begin position="180"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="313" mass="33325" checksum="995F0FD2FE5EDB1A" modified="2009-02-10" version="1">MCYLNTAVKGKGFRNIAIPKRICRQMLCSLPSHFGLKGHAVNESECVAKLNQTFTKRGFSSYSSEELLASYASLDHKRYRRTGFPEAVFAEGKTASQVALILDDMARSVNDSLEDGEIGALVGTTILATSRVSRDMYNELEEIQLHHGTMQYFDVARIVSVQASGMLDETTSKWKTSKRPRVVVATAGTTDLPVSEEAAVTLEAAGCEVDRIYDAGVAGLHRIVRAIPRLTHPDVSCVIVCAGMDGALPSVVGGLVSVPVVAVPTSVGYGASFGGISAMLTMLNSCSPGVGVVNIDNGFGAAALAYKCLRKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY38</accession>
    <name>B7FY38_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179671.1">
        <property type="nucleotide sequence ID" value="XM_002179635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY38"/>
    <dbReference type="PaxDb" id="2850-Phatr45563"/>
    <dbReference type="GeneID" id="7200626"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45563"/>
    <dbReference type="eggNOG" id="ENOG502SAXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817532_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY38"/>
    <dbReference type="OMA" id="GWANIKA"/>
    <dbReference type="OrthoDB" id="412090at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277:SF3">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277">
        <property type="entry name" value="OS03G0850700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="181"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="340" mass="38488" checksum="48A428E805847608" modified="2009-02-10" version="1">MVTLEGIRLGWEWLQWLDYTHILGLMVFIWCWKVTPSSQSAIERRYRRRRNQIPNDAFLRPGRVSEENAGPEDEVEAALAKETLLAKAMPASTLEERRRFLSAKKGSMKHATNSLAKYLEWRAEHQLSKEAITTFLVSEDIDLQDWNIAAASAIKRLGENPSAVLPQIARMHHMHAKPVCDRTGKRLVHILPGRMDEGVASLTAYALAVALYIDRKLDRNSSELVCVLIDARGGEGWRNLNAVQLMPFIKHTSKLLLELFPERLSKALVYPVPPALAWVWKIVRRCIDPLTRDKICLLTGPATIASLPPVKQMEAHLEPDTVEFLEQERVAAFLPTPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA2</accession>
    <name>B7FYA2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_12053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179701.1">
        <property type="nucleotide sequence ID" value="XM_002179665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA2"/>
    <dbReference type="STRING" id="556484.B7FYA2"/>
    <dbReference type="PaxDb" id="2850-Phatr12053"/>
    <dbReference type="GeneID" id="7200656"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12053"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094787_1_0_1"/>
    <dbReference type="InParanoid" id="B7FYA2"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF7">
        <property type="entry name" value="OBP33PEP LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="169" mass="18866" checksum="91C9AFA94ED60FF1" modified="2009-02-10" version="1" fragment="single">KRIPKLYLVITNISKRPNIRALLELAAAFGCDKVLVVGQQKFDISPKGTDIPRSIREHVERGGLHIERYSSWEACINFLSSHGIRLVGVEIHVDARPIEAYLDYKDTAFLMGNEGQGINEKHMKSCDAFVTIPQYGGGTASLNVYVAASIVLHSFHQWQQGEFSKHNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYB4</accession>
    <name>B7FYB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_11940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179906.1">
        <property type="nucleotide sequence ID" value="XM_002179870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYB4"/>
    <dbReference type="STRING" id="556484.B7FYB4"/>
    <dbReference type="PaxDb" id="2850-Phatr11940"/>
    <dbReference type="GeneID" id="7200664"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11940"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYB4"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35735" checksum="598724DF664B74A2" modified="2009-02-10" version="1" fragment="single">TAVVVGQAAKRRIDSHPHHTLYQAKRVLGRPSDDPAMTELREEVEFAVTADPEHGVVFGVPETSRPISPQQVGSYVVSHLMRITETFLGHDNIKSAVICVPAKFNAAQKLATYQAFRQAGVTVARVVEEPTAAALAYGLNRKEGVDHILVYDFGGGTLDVSLLHVSDGFVDVMGSDGDDRLGGADFDAAIAHFLLEHRHGQAVVSRVSQALQSLVQALPSNVDLEDQLSASYVSLEGFCTDLTTFRLSLTSREYEQSVQALYARSISPVTRLLNDLNLRHDDVDEVVMVGGTTRIPQIRKLVQQALPSASVNTHIDPDITVAYGAASVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYE5</accession>
    <name>B7FYE5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_6711</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179922.1">
        <property type="nucleotide sequence ID" value="XM_002179886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYE5"/>
    <dbReference type="STRING" id="556484.B7FYE5"/>
    <dbReference type="PaxDb" id="2850-Phatr6711"/>
    <dbReference type="GeneID" id="7200409"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6711"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYE5"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000595">
        <property type="entry name" value="PRK00015.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="189" mass="20567" checksum="40CE61434A6840EB" modified="2009-02-10" version="1" fragment="single">QYVIGVDEAGRGPLAGPVVAAAAVVPIDIVGIADSKTLTRESVREELYEKIVSSDNVRWAVAVIDSARIDEVNILQATLQGMRLAASAVAGISEVPDNAFYALLDGNRLPKKMAMRVETMVKGDSREYSIAAASILAKVTRDRLMHGYDKLYPEYNLAQHKGYPTAAHMDAVRKYGASPIHRRTFAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYJ1</accession>
    <name>B7FYJ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179750.1">
        <property type="nucleotide sequence ID" value="XM_002179714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYJ1"/>
    <dbReference type="STRING" id="556484.B7FYJ1"/>
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    <dbReference type="GeneID" id="7200466"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45686"/>
    <dbReference type="eggNOG" id="ENOG502QY6H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496528_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYJ1"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PX_dom_sf"/>
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        <property type="entry name" value="VPS9"/>
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        <property type="entry name" value="Vps9-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="382"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="549" mass="63261" checksum="791BA4BF2DE31393" modified="2009-02-10" version="1">MSFEASLYERCVFHSTRQYRTIRNEVIGIHKLAATLATRGVLKSTEEQLDTSRTLHQIEQRARQWEATGSFRIRSPTNAEYDVLLPLNSVRPALNVRVVNSFLNEKNGMVYTIWVYDIDDAREWYAPVRFHQDFVDLRAALTPLYDAVAKIPFPRIGRFRFGSPIRQQESDIDSSARAWQLESFLRNVVCMIYRERLHPAAAELAMHVQSFLGCGEARLLEPRLRELPEWSDSGTEASVDIFIRGKLQRSLQKHTHRIFMLDAMKQMIDPFVEGVRSRQPDLGEMEVLQVQGHIALKQKALQDLEHVEAFLDFLQGILLESCMEEYCSIASREEYELVYRELKHDESQWTRLVHEAIRAQIEIEVYVPLRSVVSRWLVYGWKHEDMEVHFKMNELRVRPQSFFCIPQDKQLDSASLQLVIDILKVGVGRRTLPCTKLRAILKAARAISSLLANQGNYGDRDGKEGSANSGTQYLGADDFLPIFIYCVVQADMERPCALCVLLRTLCDRMNRIGEVGYYLASFEAAITHIQELDLSQNLKEMQSFLPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYQ0</accession>
    <name>B7FYQ0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180212.1">
        <property type="nucleotide sequence ID" value="XM_002180176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYQ0"/>
    <dbReference type="PaxDb" id="2850-Phatr45797"/>
    <dbReference type="GeneID" id="7200809"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45797"/>
    <dbReference type="HOGENOM" id="CLU_475292_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYQ0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855609" evidence="3">
        <location>
            <begin position="41"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="574" mass="59895" checksum="FB06CCD9FD4D1FE7" modified="2009-02-10" version="1">MRLQSHEPASPRTKPASRRRSTTLALAALLSSALLSVTSAQSVSVPFDSFSLQLPLTFRCSVADGTLNRGDRDSEQIRDAADACLTTYAVSDCNLTPILVQLGATRCAGEGLVQIAGGYFIFGSGSTVTEDQVETCVRSAMESPVCLSSIQERYNYIDDVTFSLDTTTPIGVPTASPLAAPSQAPVLTPSIAPTVVATAQPSSAPVLAASVAPTLTPTGQASASPSIQVTASPSVSQGETPPPSQGETPPSSSETASTGAPVSGTATGGPTAAPNSSGTNGPTSDGVVGLEREPVAADDSASNGVIVGSVLGATLIALILALLLYRKKEDRKWKDQTANDDSLDHDDIMTRKPKSLSDKDSLSPKPRSAGVAAAAAPVGLFGRLFGTKATGCGEDEEDLEVASGGGMLLNISMAESSSTAGSGVEAYLYPPASVESFEQDRRAQSYIQKDMIGSNEDVPMSRKLNGSPPRRLFGLTYASRLNDEGIPDREETSEDDEEEEAAKMFEPKGSLYHEDLSVSTTSDSDAFTPAGRVNDGASLLDMGEKKRKYNLEQVQLAEAQERKSSPRNGTPPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ06</accession>
    <name>B7FZ06_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA photolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CPD3</name>
        <name evidence="15" type="ORF">PHATRDRAFT_51952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180071.1">
        <property type="nucleotide sequence ID" value="XM_002180035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ06"/>
    <dbReference type="SMR" id="B7FZ06"/>
    <dbReference type="STRING" id="556484.B7FZ06"/>
    <dbReference type="PaxDb" id="2850-Phatr51952"/>
    <dbReference type="GeneID" id="7201113"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51952"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026342_2_1_1"/>
    <dbReference type="InParanoid" id="B7FZ06"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01084">
        <property type="entry name" value="DNA_PHOTOLYASES_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="14">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC48262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="511" mass="58642" checksum="349FE474CFEEC07B" modified="2009-02-10" version="1" fragment="single">MLANRTRVLTSEGTEPKEGQSVVYWMQRDVRSVDNWALLWARDLAMQHDVPLHVVYALPPPASSDGSDNDRDLPPALIQLPMTKRHGAFLLGGLECVYKELKEMKIPLYVCLPDSHEKVGETVCEAILHKYKAKIVVSDFSPIREYRQWMELQAVPILEEAKVPFYQVDAHNIVPVWTATDKRQVGARTLRPRIHKVYNDYLQDYPDLKGNSHSVDQPKFDRVEYESFLQMDESVESVDWAQPGTEAGMKQFEFFSKNGLKIFHEQRNDPVQKHVCSDMSPWINHGHISFQRLALNVKALNKHANGAAAFIEEGVIRRELSDNMLYYSPNDYDSLETAAGWARESLQLHASDEREFVYSLSELEEGRTHDDLWNAAQLQMVRDGKMHGFMRMYWAKKILEWSESPVGALRTAQYLNDKYELDGRDPNGFVGVGWSIMGIHDQGWKEREVFGKIRYMNYNGCKRKFKVEEYVAQYKGAAENAANAVEETNGSSNKRKSLPSSSNSKQKTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ95</accession>
    <name>B7FZ95_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180308.1">
        <property type="nucleotide sequence ID" value="XM_002180272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ95"/>
    <dbReference type="PaxDb" id="2850-Phatr45950"/>
    <dbReference type="GeneID" id="7201023"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45950"/>
    <dbReference type="eggNOG" id="ENOG502SMTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_875754_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ95"/>
    <dbReference type="OrthoDB" id="64747at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="37924" checksum="C958C49E58BE9D6D" modified="2009-02-10" version="1">MINKFVYSLLHAPRSSESSLDRSSLLLPKMAAAPRRSLATLLLFTMKTAAVILLSLVSSVASAPAVVWKSNQRNRSGHHCSHDVHASDVLTKTLNEDGLDSEIQAVVFLLRRSKDGSETLTALASEGFLPAIAVKYDDAHVIHHHVSGIEGSNTIARGASAARPGDVVLQVTLSEFSSKLLSLEAPLEIEVSESGMLSKAAKHSNKRTRLLSEANIFIVDISANTDPAAIDRAVVAAIEHPKIGSVILSAVRSTAEVKMDRDVQARRRMQAMQKAGSSMLASNARRLDQAADGNNNQDLSGVYYVQMTPNILAGIMFFFLFTFTTYIGISCMGMIAGQTVYVSKMPSIGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZK1</accession>
    <name>B7FZK1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180160.1">
        <property type="nucleotide sequence ID" value="XM_002180124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZK1"/>
    <dbReference type="PaxDb" id="2850-Phatr45724"/>
    <dbReference type="GeneID" id="7200758"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45724"/>
    <dbReference type="eggNOG" id="ENOG502S5SR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_732521_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZK1"/>
    <dbReference type="OMA" id="GVGVFSH"/>
    <dbReference type="OrthoDB" id="497525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855643" evidence="2">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="378" mass="42063" checksum="428AB5FE8821C76E" modified="2009-02-10" version="1">MQRSLTAFSLYLATYWSLCCALNQLNSVAVLTNKSTGKDSGRPIRSLRDRSPRRPSVAVPSCHRDASKRSSRGVATRKSWNPSALVRLQNPNENAIAFNLASSGLRLVQDRGTKVYANTADPSIAYNLHAPTPETRFRFVSLNELFPHSSAMLGFSETFSTDKHFREQLRNSLRRDLFDANPTHHRLSEKARAILLQPDSSLQSSWSISSSESIPTPTPRTTALLQKTFGSTPHPTEYSIPTGVDLLNAIGSLCGRGASTHWMDIVGINDRAISHSWHQDTGRRGDGESWTVLWGFPKEDCYVGTGVFTHVLPLTHEHHAPHGHTQNEPVLFHGITVPDESIVRPCFGPGKELLVYRDIDVLHSAPDVTYRTSVMRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZM3</accession>
    <name>B7FZM3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein bL12 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_35513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180173.1">
        <property type="nucleotide sequence ID" value="XM_002180137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZM3"/>
    <dbReference type="STRING" id="556484.B7FZM3"/>
    <dbReference type="PaxDb" id="2850-Phatr35513"/>
    <dbReference type="GeneID" id="7200767"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35513"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZM3"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="5">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="234" mass="24917" checksum="A031B7C233038CA2" modified="2009-02-10" version="1">MCGGGHVAWNPKGSGTGRRFLQSDAVPLAPRFRVRSCGRRLQTSAGRSNLSTAATAVASTPAQANSDTSTNSATASPRPIIWTTHRLNATQIATVDAIFHKLLWLDLFELGTLNDEINRRLGIVLTPKQSQALERQLLVRQARIDGQSLAGPGGPAAAPVEAAPVTFDLKLVGYDASAKIKVIKEVRSLAELGLKEAKEMVEGAPKVILKNLKPEQAEELKAKLEAAGGQVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G084</accession>
    <name>B7G084_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_7942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180634.1">
        <property type="nucleotide sequence ID" value="XM_002180598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G084"/>
    <dbReference type="STRING" id="556484.B7G084"/>
    <dbReference type="PaxDb" id="2850-Phatr7942"/>
    <dbReference type="GeneID" id="7201242"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7942"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677015_0_0_1"/>
    <dbReference type="InParanoid" id="B7G084"/>
    <dbReference type="OrthoDB" id="203484at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="71" mass="8071" checksum="4C1C5E46ABCEB5E5" modified="2009-02-10" version="1" fragment="single">DLYKLLGVPRTATTKAIKQAYRRKALETHPDKQKQLPADEAAEAFRQVVHAFEILSDVASRQRYDRTGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G091</accession>
    <name>B7G091_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_4413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180436.1">
        <property type="nucleotide sequence ID" value="XM_002180400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G091"/>
    <dbReference type="STRING" id="556484.B7G091"/>
    <dbReference type="PaxDb" id="2850-Phatr4413"/>
    <dbReference type="GeneID" id="7201370"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4413"/>
    <dbReference type="eggNOG" id="ENOG502QV7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053419_0_1_1"/>
    <dbReference type="InParanoid" id="B7G091"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF24">
        <property type="entry name" value="OS07G0573800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28449" checksum="B63A5638E0635687" modified="2009-02-10" version="1" fragment="single">QEHQQTAPKLDWATDVRTLVQYNHGFAVMSTNSKADEGYPGGSVVGFAPDEDGRPLFIFSGMSAHTQDILADPRCSLTVAAKDFKGAADGRVNLMGSVELIKGDQDKAKAREIYLQKHPGAFWVDFGDFNWFRMSVEKVRFVGGFARAGAVTQDEYLAAKPDAVSEFGPKIAAHMNEDHMPATIAMVQGNVPGMEHDPENPITEAIITSVDSLGMYVKVTREKGIGFLPQSFKLRLPFPEVAKDRKDVKVRIMEMTNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0J1</accession>
    <name>B7G0J1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180688.1">
        <property type="nucleotide sequence ID" value="XM_002180652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0J1"/>
    <dbReference type="PaxDb" id="2850-Phatr46234"/>
    <dbReference type="GeneID" id="7201194"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46234"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_1_1_1"/>
    <dbReference type="InParanoid" id="B7G0J1"/>
    <dbReference type="OMA" id="WPAYKNW"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="258"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="535" mass="61344" checksum="F742207119F4FA59" modified="2009-02-10" version="1">MRKRSRFSTQVQSHEFAALESRHPYGALPGGNRFLQHVVSDKSTKNIGPSDLLTDTCWDNVLGFCDGAELGKVVQTCRYLYVAGYQPELWRDLVLRKLGTNRLQEFRSSWRDTFVALYCPSAKDSSHVPMRMPGIYSDVFYRLHSCRAFALPLAWMDANYGTVPRISIEDMTSKVFTNNYEEPNQPVLITKAAKSWKAFDKWQDLGYLLNETKGSSFRATSGLAPLPVDFSLKAYLDYATLENLEEAPLYLFDRTALQPGSHLWNDYMADLRVTCPWWDPKSNENEHDLFKVLGEGQRPDHTWLIIGPRRSGSVFHIDPNGTHAWNAAIVGRKRWIFYPPGATPPGVYPSEDGDEVALPLSLGEWLFQFWDEHVERMQSAPPHERPLECTAMPGDVMFVPHGWWHAVINLDKINVAITHNYVSGSNLGNVLRFLSKKENQISGCRDRLESIKPDRLYHEFVTSLDKYRHDLLQRGLSQKDWTCQAWRNTTTNEIKRSGRKRRKAEVAKSERNITEKASLMARAKTKEPSFSFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0U1</accession>
    <name>B7G0U1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180540.1">
        <property type="nucleotide sequence ID" value="XM_002180504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0U1"/>
    <dbReference type="PaxDb" id="2850-Phatr36253"/>
    <dbReference type="GeneID" id="7201389"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36253"/>
    <dbReference type="eggNOG" id="KOG4821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G0U1"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="315" mass="34100" checksum="1C4547E9605C5F53" modified="2009-02-10" version="1">MASYRNSDGLAPSRKRLHFRAFADKNSFLFGMILVFPSSGASDRPVWRLFYLSVDGIINFCTFGVWPFLVGIPLTKACTWLLPNALPKPLLDGLLILSCLPTTVNMCVILTSAAGGNVASSVCNAVLSNLMGIVVTPALLFHFFGSSIQLPFLEMCLKLCGKILVPVALGQLLRSTIAGEFSQKYSGFFKRSQEFALLSILWNSFCTAFVQGFGIEIRHSLTLLALLPTLHVASLATLFKIFSIPAIGLSRSDVIAGMFVASHKTLAFGLPLISTVFAGDVNLAAYSAPIMLLFPLQLIIGSLLVPQLEIYTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0U4</accession>
    <name>B7G0U4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_36257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180542.1">
        <property type="nucleotide sequence ID" value="XM_002180506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0U4"/>
    <dbReference type="STRING" id="556484.B7G0U4"/>
    <dbReference type="PaxDb" id="2850-Phatr36257"/>
    <dbReference type="GeneID" id="7201390"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36257"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="InParanoid" id="B7G0U4"/>
    <dbReference type="OMA" id="VAGKQPC"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="625"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="835" mass="94200" checksum="57721105CDE553F3" modified="2009-02-10" version="1">MNEKTSYNETKTRRKTVPSAFLMVDRYWMASNYLVVGQIYLMDKNPLLKQPLKPDHVKSRLLGHFGTCPGQNFIYVHLNRIICERKLSMFYVCGPGHGGPAMFAQTYLEGSFTERYPDISKDEEGIGKLFKQFSFPGGFPSHAAPETPGSIHEGGELGYSLSHAFGAVFDKPDLIVACVVGDGEAETGPLATSWHSNKFLNPAKDGAVLPILHLNGFKIANPVVLARIPEEELLSLFRGYGYNPVIVEGSDPAEMHPKFAAELDYAVDTILSIQKEARTHLEEGLQLRRPTWPVILLKTPKGWTGPSEVDGVKIEGSYKSHQVPVSNPSENLEHLDILEKWLRSYQPENAFDDNGKLLPELQALVPPRHLRMGSNPYTNPVISPLLLPSYEAYGVKIDKNSRGKAKASDTFTLGTYLRDVIIKNVKHKNFRIFSPDETASNRLHAVYEATNKQWMGSLNSDDDTLADHGRVIEMLSEHQCEGWLEGYLLTGGHGLLNSYEAFIHIVSSMFNQHAKWLKICKETPWRNELSSLNILLSSHVWRQDHNGKAIPTVRCWIDSDALIQSYLLQFFVGFTHQDPGFLQHVASKKPGIIRIYLPPDGNCLLSVMDHCLSSRHYVNIVVAGKHPSHQWLTPAEASEHCTEGIGIWKWASNDIGREPDIIVACAGDVPTLEALAAVSIVRKKMPEFRIRFINVVDLMKLTNTSHHPHGLSNEKFDSLFTTDKPVLFDFHAYPELVEQLIFCRSNRNFTVRGYKEEGTMSTPFDGCVMNGVDRFHLVIDICNIIEHHCRTVTEKTRWLAPYVSQDMRQLLAKHKKYIHGNGVDLEEVADWEWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0V3</accession>
    <name>B7G0V3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HSP70B</name>
        <name evidence="5" type="ORF">PHATRDRAFT_46333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180736.1">
        <property type="nucleotide sequence ID" value="XM_002180700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0V3"/>
    <dbReference type="STRING" id="556484.B7G0V3"/>
    <dbReference type="PaxDb" id="2850-Phatr46333"/>
    <dbReference type="GeneID" id="7201514"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46333"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404123_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0V3"/>
    <dbReference type="OMA" id="ITIAEMH"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="681" mass="73311" checksum="C53829F75333E6BC" modified="2009-02-10" version="1">MLPRVVDGPSIGIDLGTTNCAVAVWDSTRGHPKWMRLANIATPPRNSSKIGRVVPSAVLFLTRDAAALHNLLDEAQDVDGILERSDLVALVGNSAVKILEKSQAREIEMPFSPAQVSAAFVASVKRLIGAANSIAFRNSDFLDSLPYRVVSGGTEENNLYLEITPLGSSETVLVTPTQVSAVLLQSLRLSAGRYLRLCAAKKQLKVPGDAREPCCHAVVGVPAQYGRAQRSLIERACRIAGFTGRVLLLTESTAAAIAYGLTVGITIATTKTILVFDMGGGTTDITIAEMHPPALEAPTSVNADFEVKVTFGDQRLGGDDMDAALSRLVWQRLKVHPSDCSLHTQREVLLHGKQAKEALCGNAEHGDLQPVNSYSMTVHGRSICLTRKDFEAVIEPLIHRAKKLIQEAIRQYKATSCTSIMTDQTDAAITFDEVLLVGGATRVPAVRSLLKQLFPPPVPPELCLSLNAMAAVAQGTAIQAALWSGLIPRYDIESALMLDTVPHAIGVRLSEAHFIEVIKKGSPLPATGFAPFQLADARQAGVTVQAVEQVDIETYESIGDFTFLLHRMTKAQLANLGNDARLVDVGMKLNAQGEFVVSILDPHDPEHVKRRLNHEKIRAASADGSKAGHSVLNTYTATAEVCEGEALLTDQLVLCFVCILLFVVYVMVKLLVAEPISVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0V4</accession>
    <name>B7G0V4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180549.1">
        <property type="nucleotide sequence ID" value="XM_002180513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0V4"/>
    <dbReference type="PaxDb" id="2850-Phatr46335"/>
    <dbReference type="GeneID" id="7201393"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46335"/>
    <dbReference type="eggNOG" id="ENOG502SB3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_557226_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0V4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="490" mass="56068" checksum="0122EF09FD7D6DC7" modified="2009-02-10" version="1">MSSWTLQTRRRSHRILPLHTESTDAKRTSTAPRHHDSRTSQSLRSFPNTDGRNNSLTSFDRLSPEDDSLKRSKKARSKRISRYLVGCFSLLVILGKFTTNFRGQSSTQDVHFTSTHGSVKASPDAVFSVNGTSSYKLDTLPLIPEDHHRHKVPNIIIFTHYRDFLHEDLPYSMPNVSAAHHQRSHNLTEDQIELLALQANVRASASLHPKAQVRFLTDNDCIESLSHLLDSAEDNADLVAYFRRESIGMFKADLCRGAALYETGGLYFDVDLGVRQNVFEVLKETTRFATVLVHSASNHKGSFFQAFIASTPQHFVLKRYIELFLSYARHELDIDGPLGVILLQRAYNEMVEERPDIVDSTELWQEVMYRPGFQTNILSDVPPPTWGYRRACKFIVLANKALPLRVPFYSRIAGSRMCPFGFDSRYKTKPKKKKTGKKAKTTTSESDDNQHHFERINRKFAAGSEKQFDELWMNQSNFRTKNSAFVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1L8</accession>
    <name>B7G1L8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_36531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180881.1">
        <property type="nucleotide sequence ID" value="XM_002180845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1L8"/>
    <dbReference type="SMR" id="B7G1L8"/>
    <dbReference type="STRING" id="556484.B7G1L8"/>
    <dbReference type="PaxDb" id="2850-Phatr36531"/>
    <dbReference type="GeneID" id="7201693"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36531"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_2_1"/>
    <dbReference type="InParanoid" id="B7G1L8"/>
    <dbReference type="OMA" id="WIPLENG"/>
    <dbReference type="OrthoDB" id="43781at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="228"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="432" mass="48819" checksum="210D36E55F582171" modified="2009-02-10" version="1">MEDLIESGVVEDGTNQGRYAVIDATLEIPGRALSVTQTPVYGRHDHLTSDEVIARIERLIETVVLALERGRMPILETLWIPLENGSGGEDAVLGAQQGDILRKTFHLHQCRSFTSILLVLDFCHSLLRARRTTTTREVYYYHVTHYRSQKECDSAIQDTAILLQVPRSSLGLKASPKGWFCGDVQLVSNGQVVLDGRHLQSIHGAPISGEWLAPTRDFTIHSCAATCILVIEKEGVYNRLVEDRFFDRFPCILVTGKGFPDLSTRALVHVLHHTLGLLPVRGLCDCNPYGVMVLHTYQHTARKGVDGGHRFGVPISWIGLRPSQVQQLQRQPNTKHGQSKLPDQVFQSLTALDKRRLEHHLLSEQHGWTTFGPDERRVEELEEMLKNGYKMELEALNWLGMDFITKWLGDIFHYQDRAGHGHEGNSCWMDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Z7</accession>
    <name>B7G2Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181700.1">
        <property type="nucleotide sequence ID" value="XM_002181664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Z7"/>
    <dbReference type="STRING" id="556484.B7G2Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr47334"/>
    <dbReference type="GeneID" id="7202395"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47334"/>
    <dbReference type="eggNOG" id="KOG1778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_793356_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Z7"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="350" mass="40911" checksum="EB7E59F726C720F8" modified="2009-02-10" version="1">MSTPSSNPAGVAAPVTKVTSNEEDLRAELRSVMLKLRKREPLDPTYKRLLMNGVVTPRRPVLPKGRIYKRVGTRLRERVENYIEQNRGKDLYDRISQRQPLEEDKMRAALTLREAKDHEQQALLEATLSSLPRRNGMDEMSRRRHMEGIAMGLQNREKVPPRAFTPVPTTAAEQIEAARQQAELEQKREQARAQEETRRKREDDDRRQREEEIEQRRNTVETPQQALRRIYYPIFKKLWDMDFPHLGGINPFRIVIDRENCASVGAPDYFDVIETPMNLSYIQQKVDSLTYENLGGFFSDVELMLKNALKYNSDPSNPYRIAAEEMRKRYLKMAKKVMAVLKQNQRRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G316</accession>
    <name>B7G316_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181710.1">
        <property type="nucleotide sequence ID" value="XM_002181674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G316"/>
    <dbReference type="STRING" id="556484.B7G316"/>
    <dbReference type="PaxDb" id="2850-Phatr37532"/>
    <dbReference type="GeneID" id="7202619"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37532"/>
    <dbReference type="eggNOG" id="ENOG502RXSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071188_0_0_1"/>
    <dbReference type="InParanoid" id="B7G316"/>
    <dbReference type="OrthoDB" id="5732at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34060">
        <property type="entry name" value="POLYKETIDE CYCLASE / DEHYDRASE AND LIPID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34060:SF1">
        <property type="entry name" value="POLYKETIDE CYCLASE _ DEHYDRASE AND LIPID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="2">
        <location>
            <begin position="98"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="322" mass="35864" checksum="27DC501D1462F95F" modified="2009-02-10" version="1">MKETRSQRLSLMSAALILTLSFFSTDAFLTGGLQSSAIRHSRLDRSAFYSPTSLNIWWFGGAESEQTAQGDDSCELVPVRIERTSGNSRKIYGEIVAPVPLKDVWAILTDYDRLSTHVPNLVESRIVRPLSGGEMGDGNFQCRLFQKGAQKIVGFEFGADLTMEMKESIKPAPTILPSKPDATRQDANGASYPGNERRIQFKCCESFFFKEFDGEWKVTERTGETGLMETVLSYTVDVRPNGPVPVAALEWRIREDVPTNLRAVKLAAMTVGYKGVQASRQQGMQPASFGKSYRRNGARPGLIADLRVQWEPEETMAAYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G329</accession>
    <name>B7G329_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181546.1">
        <property type="nucleotide sequence ID" value="XM_002181510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G329"/>
    <dbReference type="PaxDb" id="2850-Phatr47358"/>
    <dbReference type="GeneID" id="7202411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47358"/>
    <dbReference type="HOGENOM" id="CLU_1006332_0_0_1"/>
    <dbReference type="InParanoid" id="B7G329"/>
    <dbReference type="OrthoDB" id="201321at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852947" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="168"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="277" mass="30891" checksum="B91347A53B16F715" modified="2009-02-10" version="1">MDVRFSGRSRAVLLLASALCCAVGAFLPATPLPSCGRISHLKYSDQTEYQEVNDSTKEVLLQLVQSTPPNAPTPAYMTNEILRVVRQLEEECPTPDDEVLSELAGNWELIWTTQDKTRPEAKRSLGRSWINPLENQSYSNNPEGRSNPFLPRPIQHRLEKLGLVTNAAVVQSTQAVDLKKQKVSNVVAFGLARVRQRASLTVKVAFRPSTIDVRRIDVKFESCRIKLPGTPIDTTIPLGLAGPIGWLQTNYIDENLRITRGHKGSVFVLKRPRRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3K4</accession>
    <name>B7G3K4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_1199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181805.1">
        <property type="nucleotide sequence ID" value="XM_002181769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3K4"/>
    <dbReference type="STRING" id="556484.B7G3K4"/>
    <dbReference type="PaxDb" id="2850-Phatr1199"/>
    <dbReference type="GeneID" id="7202278"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1199"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3K4"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF105">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="2">
        <location>
            <begin position="260"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="486" mass="53293" checksum="F8545E520A47A6D3" modified="2009-02-10" version="1" fragment="single">LPQDVVDDILQSLIRHSALNATTLRILRNCELGVLSLSGCRGVTDEWLEALSAESSDSPPHLRTALMWHPCAASSALTNTTLLDLRGSQRLTDRGLMQLHDLGRLEVAKLDNCHSVVGRGLVVLSSSPRLHTLSLTNCRRLTDEAIVNISHLQSLQALSLDGCRCITDFSLAALADMYNLRKLGLSQCDLITNEGLKALEHLQRLQEISLGWCRQVSDAGIQTLTAQPGRSSNLQILRLARCPITDEGVQYLGKIRNVKTLELCYSAVKDIHLTKLVNLPMLEELNLDSCPIGDLAIQHFANHNVLPNLVSLDLADSDISDLGMVQIAKFTKLKRLSLFYCSISNRGLRHLSILTELRVLNLDSRDISDDGLRHLQHLKQLKSLDIFSGRVTDLGCTYLSKIKTLESLELCGGGVRDAGCASLAKLENLTSLNLSQNERITNRGAAALAALSKLKALNLSHTRVNASALRYFSGLMNLQSLALYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4J2</accession>
    <name>B7G4J2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_37960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182082.1">
        <property type="nucleotide sequence ID" value="XM_002182046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4J2"/>
    <dbReference type="PaxDb" id="2850-Phatr37960"/>
    <dbReference type="GeneID" id="7202877"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37960"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_1_1"/>
    <dbReference type="InParanoid" id="B7G4J2"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57122" checksum="45BD1ABD37A39F5B" modified="2009-02-10" version="1">MAEASTIHNPDLFQNFMSTKGTYYLNGLASCQVGDRIMHPFEAHGHCKSMVFDGQGSLHLTSHLIETPLTQKEIQTNQPVARGVMSTLADPTTLWGMLQNALSPTERDTANLVASLWPPPSEATGITTNPLLITCTDNGEPYVLDPKTLKTKGKLTEVVPKLGSILDGKKCLAHTRYDPVRKHWILCVNEMDIPGENYMGNSTMIFYELDINFDVVSSRSYTTRFMVFHDWVITENYYVVPQNPARIKWAELGKFLLGATVGTDIFGMEEATNGAFLLIPRHDPNQPVRVVETDAFFNLFHFGPCFEKDNAIVLHGSVFDRYEFGGEMGFDGPTQTFDPIAWGSSGGKAPPPRLDKFVIDSTTFELTAKTRIPIVDPFSGQDIPVDMPTFRGDAIECRYAYFLGACRPEGWFPFRSIVKLDLETYETHNWDAGEEQVVSEPMWVPKSSEENKLDEGFVLSVVHDAETKSCRLNVWDAVTFDQGPIASVPLGALTPWCVHGSWTPEYNPGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4N4</accession>
    <name>B7G4N4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181943.1">
        <property type="nucleotide sequence ID" value="XM_002181907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4N4"/>
    <dbReference type="PaxDb" id="2850-Phatr47721"/>
    <dbReference type="GeneID" id="7202714"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47721"/>
    <dbReference type="eggNOG" id="ENOG502SR6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724548_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4N4"/>
    <dbReference type="OMA" id="WIAYKEP"/>
    <dbReference type="OrthoDB" id="42397at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="382" mass="42720" checksum="5AB844A9EACC6BCB" modified="2009-02-10" version="1">MKEKELLLIPEPGQKPAFLATIRVVDPSPAVVNLWNAIASDKIVLEGYTRDGWAWKPSPTLTNLTVESTDGRKKVRGFAEHLKERQKSAYGRFGTTGVWVVSYIQKKTDNDSRMDCRVSLDFTKVPHCSLKLRSLAVPPSKNEPPAKPIEARPAGKKSGFLGKLVGAQQRTNHHVAMASTARKSASPSLSSNSAHAGSIGESAATKTAQKVLAEFRQACQDKMLDFDLAAEEKLEVPVTLATYTAGLSFEDKAKVTMEILKYMVYEAAEEVNEEWIAYKEPGGFMDEATFAIYKEGAAPPEVLEELNKGELPDEVIGQQRAMQDERVRQANQAEQRHKTQLELAAHRQTDEEENDDFAALNSNKRDRRTIEDYEREKRQRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Q8</accession>
    <name>B7G4Q8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182116.1">
        <property type="nucleotide sequence ID" value="XM_002182080.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47739"/>
    <dbReference type="GeneID" id="7202911"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47739"/>
    <dbReference type="eggNOG" id="ENOG502T0M6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245068_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Q8"/>
    <dbReference type="OrthoDB" id="49523at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1582" mass="178232" checksum="903BEF8CCC9D5403" modified="2009-02-10" version="1">MDLRSLIYGSNPPPKPNTDVPLSDADAHEPHNHSAFSSSSARPPVGKVEEVDGNDVDEHDVPPGFASHSVSALDSTNLPSDVPSAGNGPLHDTHRTNAVPPSLPPTDDRNTGPTDELYQNPYLDESNAAARLNALYQAANVHDIPKQSRSTHHGFPKSSRPRPSSPPPLPAQQQTIDSRAPLQKLVQSATHYIPARLETVRGTAATLPPVATVDIQSEPQNQRRRRRSRPPPKPKPPKTPEYYAVKQRKYELTAEWAVVRNRWQKRKYDYRDEPDVGNVVSRTIERVWRIRPEPHINNPTNTRANQIDSATSVFAKRQADPVLEEEPKDDENTAMVKKERGSVDPYVDTSDEEQDAIYRRLVKSSLREQRNHAMAASEGGTKDLRPWSERLDFYSLGYAVPRDHEIPVNYWEYVKKHGFVRVPDQVLEQDNDTDDQEIVSGSSNTVTIGTFHSNRFSDALNKLPPVPRNFPYRQPTCSTNLPFHFHRCYALQMAAQLTVGMAGLFDDGALALSTRTLRLLCQKTLYENDQSSLVRLWTGIHGDMLQLFVRNTWKNRREVAELLGLTPDRNSTGPLDLIGFQTDLGKALPRAADRIRQELQKKYKISAVPWDATTSLPRVGSIRANNRTRSFAPQTPYVFLPGTIPPKPTLPMDVTGIEFGTADRNSTVSYWSKVDHKCVVLASALLVAQIATARLSTTTKTTYKKSCALLRKLLQETITSNTSNWYKRYAIAWKEPVEVPLVALNYAVMDFINMSLNGVATVSNQRGEGVSDKENESMSGEVSDEESILSNANPEEAEIGVDAIAERLVNYLGDRIEHNGLEFFSRPHLSFGLLQIAKVLPESAARILGSPLDHDVFRTPFDVFRSTLQHLEDNGLLFDQSVASRSIGINVAQLEHAIYQATVSFSRCVDREPTNTEYHAWYIGGLASALLLSSGNKIGSGARCYPSQLTSKEREQRALVLLTGHVAESSDTHGVRQMLSKFNQLRRETAKAFKLLCGLVQRQETSRSHLVMKSFLEWKQALALMIGAPAQSKDTFRVIRQMHQRHLMMWSRKEQSLEARNILYEMEVCKDARLEAAASALEQDPTDLKNWRWLIQEIGNLAHRVSQQKQGKCKFCLDCALVRKDLNIDHQHRERVVREGWMKHRHGIWEGLFNSLSSKRIRALTSDSVRICRILSQRPAARQVPVESPEETNQQNTTKRLTFSDPVDWLDEVITEVVDRKEQLSAQMRNRTYDNDLPGQEFISTGQFTTDCEKLVNVSDDMELLCYKIYLLCYMYGPSHAAVEPAIISLVNKCWNVKSPRLVLMSNKDECKCLDWLSSRGLNIAAIVEKRCLDQVYETRSGDPLVRGAVTRQMREAIKDSIAWKGYFSVAFTLTNYEAFKPHTRNRCMTVFTRMVQVGEVEDVRDGARSLKTAYKAGFVEHADGTRHSRDPLVESDRFHSYEAPESSAPRDWTWASVYGFWVPQGYGWDPVEQKLVEGRPLPIAKPKKMTKKTSIPNLKSGIKQGNKKCASKRSPTHRLSKPATKRRKREVESLDDGQGKTPIQPSLETTVVCDINPKPGTSLPANTLTDNVMTSADLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Y9</accession>
    <name>B7G4Y9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_14444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182322.1">
        <property type="nucleotide sequence ID" value="XM_002182286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Y9"/>
    <dbReference type="FunCoup" id="B7G4Y9">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4Y9"/>
    <dbReference type="PaxDb" id="2850-Phatr14444"/>
    <dbReference type="GeneID" id="7203047"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14444"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_2_3_1"/>
    <dbReference type="InParanoid" id="B7G4Y9"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="180" mass="19955" checksum="887EB7C1CF3C0E7B" modified="2009-02-10" version="1">MKKKTPIRTMVVLGSGGHTTELLALCKRLDRDRYELVYVKASTDTTSASRVQQQNSDCSTTVTIYDIPRSREVGQSYASSVGSTLYATVYAFRLVFAVRPDLVLCNGPGTCLPIAVAAFIGRIFCVMGGRIIFCESFCRVQTLSLTGKLLYAWVDIFIVHWPDLHRKFPMSVLGSSFVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5K3</accession>
    <name>B7G5K3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PCNA</name>
        <name evidence="10" type="ORF">PHATRDRAFT_29196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182261.1">
        <property type="nucleotide sequence ID" value="XM_002182225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5K3"/>
    <dbReference type="FunCoup" id="B7G5K3">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5K3"/>
    <dbReference type="PaxDb" id="2850-Phatr29196"/>
    <dbReference type="GeneID" id="7203226"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29196"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="B7G5K3"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="29084" checksum="96C902218DFD3D7E" modified="2009-02-10" version="1">MFEARLVEGKIFKQIIESIKDLVTDANIECTEEEIAIQCMDSAHVSLVDVTLSAAAFDHYRCDRNLSLGFNSANMSKIFKMMNPDDVVVMKAEDNGDALTMMFESTKTETIADFELKLMEIDSEQLAIPETPYNCTIQMPSTEFQRIVRDLQVLGDTCQISCTKEGVRFSVTGNIGTGNVLIRSNAAAEKEDDRVVIEMQEPVELTFALRYLNFFTKATPLSGHVIISMAPDIPVMIEYPISETGHIKFFLAPKIEEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G614</accession>
    <name>B7G614_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182496.1">
        <property type="nucleotide sequence ID" value="XM_002182460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G614"/>
    <dbReference type="PaxDb" id="2850-Phatr48114"/>
    <dbReference type="GeneID" id="7203471"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48114"/>
    <dbReference type="eggNOG" id="ENOG502RRCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519248_0_0_1"/>
    <dbReference type="InParanoid" id="B7G614"/>
    <dbReference type="OrthoDB" id="79455at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="213" mass="24177" checksum="62635DF5D985E168" modified="2009-02-10" version="1">MGEIDIKKMKVAELRTELERRGLPVSGNKPDLINRLQARLDEEEFGLIDAPATTINTTMTNLNETGEATGDNPSDSATEREKKGLVPTKTEEMGEESKTDKFISEAHDANNVKVSAQPTFDEIKRRRANRFDIPVVETKVQSPQKRGRDKKKSANLPILQKGSKRARQQASEKDDVLLPKEEIEKRLKRAEKYGTGNEENILKLKAMLRKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7G649</accession>
    <name>B7G649_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182662.1">
        <property type="nucleotide sequence ID" value="XM_002182626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G649"/>
    <dbReference type="PaxDb" id="2850-Phatr48144"/>
    <dbReference type="GeneID" id="7203488"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48144"/>
    <dbReference type="HOGENOM" id="CLU_1242211_0_0_1"/>
    <dbReference type="InParanoid" id="B7G649"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="25497" checksum="ACB50BC17E112111" modified="2009-02-10" version="1">MHSLRSAVRNISHNLDCGASAISAITESLQCEPRPWEAIPTNDRAKPSSFRTPKNLQSKRRRVHFFVDENDCVWPDLVVGQAPISMDEAARLWWSPQELDEILQYTRYTAEFHRVVRPEFSELVAELFGACLKSNANEIAVRINTAVTAIVNSVARGLELAVAPQLSHRRRYCIDEVLKTQKRLNHWPSDRRIRILAKQYQRIGKYAHIMARVLADGDALEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6F4</accession>
    <name>B7G6F4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="449" mass="49585" checksum="382FCCDC9ED92D47" modified="2009-02-10" version="1">MEREEPGSPNEGSEQDATEGIDTNHSESSSPLPSATQNQDQHESAKPATSVWKGLSEIMSIVLGRIDDGRDTKSKERPDTVLRPKGAEEVGDPSTLEANEEKVAAKPQESEMPNATFPNSGKLVRKFAVKRSLGRALSQIDNPEKEQQNKRLGEQTTQPDDRISANFEKEENLLEERNSTARELLEQEWNDDQDEDDDRIAPSSVERTIEEANDTASDAEMTTADPPQSNQDRQMNQITAAVDLVIDSLTTGPWPSPPRCVDPASVSRRALDMKRAEMELDLHEQHLSMVSVSLHQFATDVIAPAMIAGGVTKDDDLRVFLGTLLILREVLTTNARAIFGASAIVSGSEPDFSHRFKKTNTNLGRREEFALFGARILATSVILAGLDGLDDEDSESLAAEFLRRAKMYDNGDEEFSDNLIRIDGSNRAYLPNGSPLPPEERIAWQVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Wyrwicz L.S."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">CCAP 1055/1</strain>
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    <reference evidence="13" key="2">
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                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502RRCD">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0012505">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
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    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855829" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="149"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
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                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002182566.1">
        <property type="nucleotide sequence ID" value="XM_002182530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6F9"/>
    <dbReference type="STRING" id="556484.B7G6F9"/>
    <dbReference type="PaxDb" id="2850-Phatr14702"/>
    <dbReference type="GeneID" id="7203350"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14702"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283502_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6F9"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="273" mass="30321" checksum="2B99782E3DC18CC8" modified="2009-02-10" version="1" fragment="single">VEQDYDIRDVLGSGTVGQVLRAIHRQTGHERAVKIIKIKSNYTTASEPAASSATLQAEAAILQSLAHPYIVQLYDVYVSTTAIYLVMELLPGGDLFDRIVDKGIYTETQARQVMRRLLAAVHYLHESCNVVHRDLKPENILLCTSDNDVHIKLTDFGLAKTIDEQGLRTFCGTPQYFAPEVLHRQHTVAGRGRYGKEADLWSAGVILYILLSGTPPFDVQSEGIDAVANSTLQFPTAQWWGVSPAAQDLIRRLLVADPAARWTVVQACQHDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6W2</accession>
    <name>B7G6W2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182800.1">
        <property type="nucleotide sequence ID" value="XM_002182764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6W2"/>
    <dbReference type="STRING" id="556484.B7G6W2"/>
    <dbReference type="PaxDb" id="2850-Phatr48365"/>
    <dbReference type="GeneID" id="7203635"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48365"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370682_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6W2"/>
    <dbReference type="OrthoDB" id="47254at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="91"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="751" mass="83808" checksum="2E17E3C327FC854A" modified="2009-02-10" version="1">MLSALQSSRRPDSSESASLGPSSTLGNVSHGFRSRFEMLFYPENSPLSDQGFHTKQEDIQACLRGKVDESTGNEMVNLWQLRELSLSKGGLLSADLRKRAWPTLLACHEQVFPELAQQDDYVAPRRVQPDPGNIRSLQHDVSQTIWNVQDCLVASRQHRQIQNEKMDRFLEEQRQQSQKKVTFAPSLVQASPKPHTPAPKAPETPPVVIATSSPASGARAHQDDTTSVLSHDDSATGLFDDSSWSVRTHETAFTLSSRVIRWRKASSQEQKILYNVISSVLQTGPPIHGNDEVYFHYNGLQDLTALLLINLESPSLTSIVLEKLARWHLRDALRPDRSHIEIVLECCFMPLLESVDSGLYNHLVNKGLTLPSFATQWIACWFAQDIPDAPMASRFLDAFIVGHALLPLYVAVAFVASHREWIWSECENLSSLYATLRGIPFRALTHGLDLQDEEDVQQGMMRVERILETALLYMKRLPPSDLLEISRNRVVSGEVLEQISTISMFGPENVPIFVTGPHSPTDYAVLQQAKWFRTKLSQPTFSLKQIGGAKNEELPGLANSPTLEEEDEPEGSHTPGPESYTLTCVALGISNVTSSTRSRRALGSLWMLLFVGVLFAYLAVVLPPQFHLFGTQSTAVPLHLSRGSEPDSRRASDLTNPKLQGTLGLSQLKFTFQGFATSVVTENVLMEGDYSDMIKESRALPSLSSVFKINWFAVFRQQFHLLQAVWRDLLSPFRHRKASAESSKEDLTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G767</accession>
    <name>B7G767_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_22453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the divalent anion:Na+ symporter (DASS) superfamily. Na+/sulfate symporter (TC 2.A.47.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182977.1">
        <property type="nucleotide sequence ID" value="XM_002182941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G767"/>
    <dbReference type="PaxDb" id="2850-Phatr22453"/>
    <dbReference type="GeneID" id="7203628"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22453"/>
    <dbReference type="eggNOG" id="ENOG502QPZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G767"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1450:FF:000009">
        <property type="entry name" value="SLC13 family permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="entry name" value="Regulator of K+ conductance, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051679">
        <property type="entry name" value="DASS-Related_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652">
        <property type="entry name" value="BASIC AMINO ACID ANTIPORTER YFCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF2">
        <property type="entry name" value="BASIC AMINO ACID ANTIPORTER YFCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="TrkA C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="622" mass="65897" checksum="D0E351B3624C0DB2" modified="2009-02-10" version="1">MFAALASDRLGADSIILAALTALMAAQVITVKEGFQGFANEGVLTVLALFVVAEGITKTGALDWYIGKVLGSPTNASSAQLRILAPVTFASAFLNNTPIVVVMIPIIQKWARNIHIPVQQLMIPLSFASILGGTCTLIGTSTNLVVVGLLEERYPNDPDVSIGLFDIGLYGVPVALVGMAYILFASPYLLPGGGGQSQDALNSLEKNEEILLGARLTSWSPAVSRTVKRSGLRDTGGIYLVSVVRAATGHAYQSIAPEEPLQHGDVLWFSGSASSVGDLRKIPGLISYQNDEVEKINEKVHDRRLVQAVIARKGPLVGKTVKEVQFRKRYGAAVIAVHREGKRVHEHPGNVKLQAGDVLLLEAGPSFIAKSGENDRSFALLAEVEDSAPPRLSLLIPALLITAGMLVVFMADWTSLLVSALVASMLMVALGILSEQEARDAVNWEVFITVAAAFGIGTALVNSGVAGGIANFLVDVGTALGIGEAGLLGAVYFATFLISNVVTNNAAAALLFPVALNAAEQTGTDRVLMSYALMLGASASFMSPFGYTTNLLIYGPGGYKYKDFLLFGTPMQIVLWVASIAFLAIIEPWYISWIAAAAILGIIIALRLFCLSRTALRAGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G772</accession>
    <name>B7G772_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182980.1">
        <property type="nucleotide sequence ID" value="XM_002182944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G772"/>
    <dbReference type="PaxDb" id="2850-Phatr48457"/>
    <dbReference type="GeneID" id="7203747"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48457"/>
    <dbReference type="eggNOG" id="ENOG502S3NZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708764_0_0_1"/>
    <dbReference type="InParanoid" id="B7G772"/>
    <dbReference type="OMA" id="WTEIMEL"/>
    <dbReference type="OrthoDB" id="272750at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF17">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855509" evidence="2">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="42734" checksum="FC8A267C2CE8F938" modified="2009-02-10" version="1">MISLLPFLCMLASMASPSRSFTISATRNLYQNPNPFRCRSTPHRVPTLLGSSFYGNFDADEDEEEDDDDEDDDFQDLDDDAVADFRSKMSNLFGDGTGSSSSENAPTTAGGTDSSSVESKIDDLITFARSQDGSTGSVSTDWSEPVSSIQKGMVLLANPEQFCSDFGGGRRKMPSPKLLAKFGLTLPPPADLGPDRRADLLPVLIVVECGEGSRVRAVLLNRRTGYLLGDLEQADTNLGSTSSKKAPTPVLEKFCIQPLWFGGVDNVSAGLDMLHQCPTVPDAEPLSDEGLYWGGDPALAQDAMDEVTDKVLTGFDFKFFVQSTVWGSSKELQKEIDNGTWFTARVSKEVLFKSRDRMGTRRAKPLWTEVMELLGGKYKDTRDMLYDQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7C2</accession>
    <name>B7G7C2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">subtilisin</fullName>
            <ecNumber evidence="8">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_38966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="8"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183005.1">
        <property type="nucleotide sequence ID" value="XM_002182969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7C2"/>
    <dbReference type="STRING" id="556484.B7G7C2"/>
    <dbReference type="PaxDb" id="2850-Phatr38966"/>
    <dbReference type="GeneID" id="7203772"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38966"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_1"/>
    <dbReference type="InParanoid" id="B7G7C2"/>
    <dbReference type="OrthoDB" id="47834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853060" description="subtilisin" evidence="12">
        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="137"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC45741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="555" mass="58895" checksum="E3FB1DCC2723A1EB" modified="2009-02-10" version="1">MKYLNAITLLTFGWMPSLSAQVLTHRKLQRLPQSQVIPGQYVIELDPSIPDSQGFAEKVLKRTFRKNIIETYDYAMKGFAVKDVPDMVLNFILNMDDVLSVSEDGIVEIEAIQNNPTWGLDLVDGSDDNRYTYTYTGRGVDVYIVDTGIQANHPDFEGRVRSCVSYTGESCGSDLNGHGTHVAGTVGSKTYGVAKQVSLHDVKVLNQRGSGSYSGVIAGVDYVTKIKENNRSRRIVINMSLAGGVFARLNSAIDSAAAQGVVVVVAAGNSGADACNASPASASGALVVGAINDRNQRTSWSNWGSCVDIFAPGTGILSTAKTGGTSTKSGTSMASPHVAGVAALYLESGRNTNSITSDARTGQLGNLEGSPNRLVRTSRLPARNTPQDDTDAPVRAPTRPPTRAPVPAPTRRPTRAPTRAPVPAPTRRPTRAPTRAPVPAPTRRPTRAPTRAPTRRPTRAPTRAPVPAPTRRPTRVLTRAPVTPRTREPTRAPVPAPTQPPVAPQCLPAADPGHRLVDSTALVDLNLAGGATSSLALGDNCFLAMLSLAKVSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7W3</accession>
    <name>B7G7W3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AP2sigma</name>
        <name evidence="12" type="ORF">PHATRDRAFT_54935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183216.1">
        <property type="nucleotide sequence ID" value="XM_002183180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7W3"/>
    <dbReference type="FunCoup" id="B7G7W3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7W3"/>
    <dbReference type="PaxDb" id="2850-Phatr54935"/>
    <dbReference type="GeneID" id="7194825"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54935"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_1_1"/>
    <dbReference type="InParanoid" id="B7G7W3"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC45434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="152" mass="18079" checksum="11DFB06083CFAAC3" modified="2009-02-10" version="1">MIRFFLLQNRQGKTRLSKWYVPPPSTQNGSTVSPEAEKVRIEAEVHRLVTARDKKYTNFIEYNNYKLIYRRYAGLFFTIAVDLQENELSYLETIHLFVELLDSYFSNVCELDIVFNFNKVYSILDEFMLAGEIEETSKREILDRVKLLEKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8F8</accession>
    <name>B7G8F8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183338.1">
        <property type="nucleotide sequence ID" value="XM_002183302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8F8"/>
    <dbReference type="PaxDb" id="2850-Phatr39364"/>
    <dbReference type="GeneID" id="7195069"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39364"/>
    <dbReference type="InParanoid" id="B7G8F8"/>
    <dbReference type="OrthoDB" id="44357at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="203" mass="22683" checksum="1DAA9FD32528B2E6" modified="2009-02-10" version="1">MALEELFQDVGVPTHMHTDGAKALTTGQWRKVCQSYGPVKQMVSEPLNPWQKRAKAEIRELKKQVLRIMSHKGIPRRFWDYVAEYVSEIQSRTAHPLYNLKACVVLGPWGLSGGKEIAWPVVGSCSSSWTGFCWIVPQLGRVIARSMVQPVSEEERGLDSFKTRLKDLDKSVQDFLNRGDTHVPDGGVGWKANCVTGVHHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8H5</accession>
    <name>B7G8H5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_48819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183346.1">
        <property type="nucleotide sequence ID" value="XM_002183310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8H5"/>
    <dbReference type="STRING" id="556484.B7G8H5"/>
    <dbReference type="PaxDb" id="2850-Phatr48819"/>
    <dbReference type="GeneID" id="7195077"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48819"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275778_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8H5"/>
    <dbReference type="OrthoDB" id="1743979at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050060">
        <property type="entry name" value="Phosphoglucosamine_mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE (ALPHA-D-GLUCOSE-1,6-BISPHOSPHATE-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946">
        <property type="entry name" value="PHOSPHOHEXOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855893" description="Phosphomannomutase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="6">
        <location>
            <begin position="159"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="350"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="448"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="74178" checksum="198FEBDD19EDD09F" modified="2009-02-10" version="1">MRVCTTQYSSLFRWLFWTTAIPAAFAWSPMIPSEPRRSHHTTRPKFGRVASVLAATVQPDKDQAFTTKSSTRIAQSRTGRNDQSPPDFLTLAFASTECDNVNRPPSLNVLIRSIEHLTTASDGHMLTDVRGVFVDHARLGSIAAVAHAIGQLPVGSVPPLTPLAVYCLGHAFASQLLEDTPAEENVTILVGRDPRIHGMRLADALGRGAEAADPRIRVVYTGIATTPGCASFVRSGRADAAVMVTASHLPRDRNGLKFFRRARTLDARVGDDSASAVSIADLGARAIQCATEWHSAGILPPASGKDSVMCSAWVDWMPYYAKELRQAIVDQVGHQSCDKTSANDQISQQPLRGLKIVLNAGNGSGAFFHKILQELGADTTGSLHLEYNGEFPNGVPNPESPAMVSETEQACALVKADLGILLDTDADRCGFVVPSRHDKNTYEPLNRNRLIALLGVIMSRSSPGSAIVTDSVTSEGLATFLQGSLGLQHVRYLKGYANVIGKARSLSESNVVAANLAIETSGHCAFRENDYLDDGTYCAVKVLSLMARERAANAKSNLLDLIADLVELDEVAELRMATLDDSLDTMQQVFDLCALELERHAQNSDIEWEIDVDNLEGIRIRIGDGQFFMLRKSLHDPIISLQIEASSKDIARRRIMVPIIELFDSLEQIQAQLDLSVLRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8P4</accession>
    <name>B7G8P4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_15310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183378.1">
        <property type="nucleotide sequence ID" value="XM_002183342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8P4"/>
    <dbReference type="STRING" id="556484.B7G8P4"/>
    <dbReference type="PaxDb" id="2850-Phatr15310"/>
    <dbReference type="GeneID" id="7194956"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15310"/>
    <dbReference type="eggNOG" id="KOG1865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464229_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8P4"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="190" mass="21507" checksum="7E29A86F15080A74" modified="2009-02-10" version="1" fragment="single">EDAHEFLRALLGTLTMSGQNKSLSSLFDGLLESAVTCQTCRRPSLTRDRYMDLSLDIQAEQIETLTDALHEFTKTELLNGENKVNCGRCGTKRIATKGLRLATAPSILVCHFKRFAFDRFGNVARLSRKVQFPLRLEIGAYMSRVNKARPPPYDLVAVLVHQGQSCERGHYVAFVKKHGEWFECNDERVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8U8</accession>
    <name>B7G8U8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183408.1">
        <property type="nucleotide sequence ID" value="XM_002183372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8U8"/>
    <dbReference type="PaxDb" id="2850-Phatr39507"/>
    <dbReference type="GeneID" id="7195183"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39507"/>
    <dbReference type="eggNOG" id="ENOG502SVQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G8U8"/>
    <dbReference type="OrthoDB" id="56766at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="607" mass="68601" checksum="3F4F19F2C74A9C08" modified="2009-02-10" version="1">MSMRHVARRHTVTLLSYSDMTLIIKPFVRSDENAEKYVPIFSQMIRSTGNQFESKIRQLILQYSDQEATELQMAKLAETADDWLTQYARIEVAEVPANLRASLMLYEGVEINQVAQNTTFSMRENINVLSKELQKLLHFLWKQDAADTVLFARRKTQISDHLKLNDSSTQIIQMGLIGKLLVDVLLENPCSTSQYPLGCSYAASRCFFISKGKLVLRSADESASQVATIMHLFRLAYCSVVGTMSNPLGYMEGGKVLVKTVMERPMMNTFGPMIRQLREIQMQKPKIIDRHFSRNGEIVVQGLIFKPEVWKTLIPRVVGAARLVLSQIFDGKDWEVFLTTTLPLLNVRISGGADDGVHFQVQQASGDVSSDSLELSPQLNEMDQDHLSSIVEFCLHGLGLGSMRHSETLGLQDFQVLWGNGALYFYAKSTKKWKAQVPDDLQVRHFFASLSNYLFPVQDDGKATTSDMVAMQSHHAPSTHASTYFTHRKTHLEDYYDAYHFHLGDKDTQWTYDIPLDVLPEQTIVAALKILYGGEANWLSETQRSMVLTWSTLSKNVVANLPCGGGKSAVWEVTAYTRHRVGLTRKCTVVVVPYKFLAYNHYHSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8W1</accession>
    <name>B7G8W1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183660.1">
        <property type="nucleotide sequence ID" value="XM_002183624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8W1"/>
    <dbReference type="PaxDb" id="2850-Phatr39520"/>
    <dbReference type="GeneID" id="7195350"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39520"/>
    <dbReference type="eggNOG" id="ENOG502SZX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603375_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8W1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="454" mass="51206" checksum="D1F0CEC67649012F" modified="2009-02-10" version="1">MSSSLQGANATSNGAMALLQKFAALNNHIEEIRRQQNSVLREIDSVQQQLVDVGEDREKMCEKTDEAGKSLIQLEQRTKDALDSQLQVEKGHSEALLTNQVCARRLEAARQDTLESQQAFLERTRNFRHSCRRLQLRAQHMGIQHASLRAWIAAKGETISGTDLVGDQRHQTYGSRYRNSKFDIRDPDSWGLEVVQGDEELHELFLKYESKKSDLDLAQKNREIARIAWQEQLTNADTRRDRRTRLEEQLRRIEGDNDALESQMRELEWQTARVRETATVPELLKSTVQLISRSTNSTKTQQSSAAVTPTTGCRSTTGLSSRVAFHRTNPYANTGKNQYKNRISSTDSNVISTPEIRLPALHSEASDFRDSASASIGRRGRRLGGSEFGLSMEIVGEPSITSMNYKKATDTCFNDPHISLPADDSLKRTIASLQDSDGEDFSYMPFTKKSNQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G995</accession>
    <name>B7G995_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3">4.1.99.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_15625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183598.1">
        <property type="nucleotide sequence ID" value="XM_002183562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G995"/>
    <dbReference type="STRING" id="556484.B7G995"/>
    <dbReference type="PaxDb" id="2850-Phatr15625"/>
    <dbReference type="GeneID" id="7195286"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15625"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_0_1"/>
    <dbReference type="InParanoid" id="B7G995"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="335" mass="37620" checksum="563EE8F950198578" modified="2009-02-10" version="1" fragment="single">VLTDTFQRQHTYLRLSLTERCNLRCTYCMPEAGVPLQPASHLLQTPELLNIATYFRQAGVTKFRLTGGEPTLRKDLLDVVKGLKRLDPHQIGMTSNGIKLHKELPDLVEEGLDSLNISLDTVDADKFATLTRRPAAYLDRVWQSIDVAHDLLKDHGSVKLNCVVMRGTNDDEVANFIQLTETYPALSVRFIEYMPFSENGWNWDKCVPYQELLDQLETGMLKAVPVKDPHDTTKWFRTASGGKIGFITSMSSHFCAGCNRIRLAADGSLKVCLFDGVTEISLRDAVRDYDFTDTELGKLVHYAIQKKKFSLGGHKDPQDIMNDAANNRPMTLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9I1</accession>
    <name>B7G9I1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_15641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183776.1">
        <property type="nucleotide sequence ID" value="XM_002183740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9I1"/>
    <dbReference type="STRING" id="556484.B7G9I1"/>
    <dbReference type="PaxDb" id="2850-Phatr15641"/>
    <dbReference type="GeneID" id="7195455"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15641"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_3_1_1"/>
    <dbReference type="InParanoid" id="B7G9I1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="349" mass="39011" checksum="6F291B053C1B03C0" modified="2009-02-10" version="1" fragment="single">NIIGPQGDFVTAPEMSQVFGECLGIWFYDQHKKLQKAKADGKRLDWQWLECGPGKGTLVSDLLRFACYGKIRHEFGATCKHVHLVESSPILRQVQKETLQRDLRDVAELEFVEESGIPENRNPNAVQVHWHDSFASFRAWQKQSTSRLTTYAVGQEFLDALPTYQFEKTADGTWRERLIDVALKHLPNAKKPRLRIVLAPLVTVPLKTLLQVDGDGRMLNEPNFAQTGSVVEVSPEAILLVKDVATLVDEQGGAALFIDYGQEGSADTIRAFAKHEQVHFLSRPGQVDLTADVDFSALKHAVNALQTRHQTRAFGPVGQGHFLMSMGASDRVLQLIERDSTTDKEADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9R2</accession>
    <name>B7G9R2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183933.1">
        <property type="nucleotide sequence ID" value="XM_002183897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9R2"/>
    <dbReference type="STRING" id="556484.B7G9R2"/>
    <dbReference type="PaxDb" id="2850-Phatr39832"/>
    <dbReference type="GeneID" id="7195668"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39832"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531551_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9R2"/>
    <dbReference type="OrthoDB" id="202844at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57957" checksum="726D0936C3D8E66D" modified="2009-02-10" version="1">MKATSVSTPNIHLWSSRHTVVSGTTGTDPSVPNQSGSASLPPRSAWVRTCLCARNLLMFAIVALHFSSFLFVLQSPADRDPESLVPDERNVRRRHQNQSVSIPVFIPTTSTPAAAATSWLATGSSQPRAPSSPYAYTFVIGAIHEDRPAYKGFIYDILVSFHSLQKLGSQADFWVLAQLAPDSNLTELPAEDMRALHTLGVRVKMLPQSESDSFAEFVYNKFLVFRMTEYRRVLFLDADLIPLANLDYLFHLSDQGEASLIRPNLIIATRGEPCNAGFFMVEPHEKAWQRLQGIVARHHEEAKTLPYPHFDWRNGWGHNFQKAGDEWRAVLRNGQAWRFHAGHSDQGLLYYFLKYAQQDVTLVIGERVENWVPGTVDGQPQMAANLTTPFNNYTTDEARAKKSSCLVQNTAYECVPPYRDFMHFSGSSKPWQGMLPRAFVLAHEGLDRWEKLPTPLWPSLLWFKELIEVNDLLQLGLDVENWNEQHLPRMKDSPMGYIAKFADHANHVHGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Y3</accession>
    <name>B7G9Y3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183970.1">
        <property type="nucleotide sequence ID" value="XM_002183934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Y3"/>
    <dbReference type="PaxDb" id="2850-Phatr39906"/>
    <dbReference type="GeneID" id="7195702"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39906"/>
    <dbReference type="HOGENOM" id="CLU_704888_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Y3"/>
    <dbReference type="OrthoDB" id="47806at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="403" mass="43794" checksum="5E1D2027C91193E2" modified="2009-02-10" version="1">MNLSFLPFSSNSFAILATTPTVKVGQEQGSYKSIKIVPGKNDILLGRVPQTHRLALSTGGKNNQHSGNVQLRNLARSFCSVYHGAKKKEKPAIAQSLVGCVRNLSPPGRFLKHTVEGWEEATESVAQEKASQSLRDTVASVLKEAAIQDGTELPTEIFTQACLKGPCPVSSRRHATAKTPISMHLQQSNEQLTQNDSASLFTTAFSSHTSISDSPAVHYGNRLLPPIDVTLSAFSLESSVGKQRKISFPGRNPNTVNQHSQTKRARYTAAETGNYTFEWGLIPKLQSMSSDGFYMSCHGLPKLLSGIGTGNGGISLNDVAQYAHLATQREKNSNMSEFSVSDNFEEGKPIGADALDAIVWDEDDIDLDSSSSFPIAPSQHQEGASWDDEDAFRRNILSLLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Y4</accession>
    <name>B7G9Y4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_8181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183971.1">
        <property type="nucleotide sequence ID" value="XM_002183935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Y4"/>
    <dbReference type="FunCoup" id="B7G9Y4">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G9Y4"/>
    <dbReference type="PaxDb" id="2850-Phatr8181"/>
    <dbReference type="GeneID" id="7195536"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8181"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_3_1"/>
    <dbReference type="InParanoid" id="B7G9Y4"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="77" mass="8754" checksum="707206053D8C0B44" modified="2009-02-10" version="1" fragment="single">QVQTKKRVKLSKRFKCPFCANEDTVECKMDFRAGVGSLNCRLCAAAYQMPIHHLHEPIDVFSEWLDDCEAAANPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA40</accession>
    <name>B7GA40_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SDH2</name>
        <name evidence="18" type="ORF">PHATRDRAFT_52539</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="15">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184001.1">
        <property type="nucleotide sequence ID" value="XM_002183965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA40"/>
    <dbReference type="SMR" id="B7GA40"/>
    <dbReference type="FunCoup" id="B7GA40">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GA40"/>
    <dbReference type="PaxDb" id="2850-Phatr52539"/>
    <dbReference type="GeneID" id="7195465"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52539"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="InParanoid" id="B7GA40"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13 15" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="16">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="273" mass="31173" checksum="98F0547186EE92C3" modified="2009-02-10" version="1">MLSSSSTRTTKTLFSRFAARSFATADLKANAIPKQAPRIKYFKVYRWDPEQSQKPYLSTYPVDLANCGPMVLDALIKIKNEQDPTLTFRRSCREGICGSCAMNIDGVNTLACLSYIDQKDTSSATKIYPLPHMYVIKDLVPDMGNFYEQYRSIEPWLQPEKGKEPGQAEYLQTREDRAKLDGMYECILCACCSTACPSYWWNADKYLGPAVLLQAYRWIEDSRDGSTKKRLEELDDAFKLYRCHTIMNCTKVCPKHLNPGKAIAQIKKRLADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB47</accession>
    <name>B7GB47_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_30471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184308.1">
        <property type="nucleotide sequence ID" value="XM_002184272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB47"/>
    <dbReference type="STRING" id="556484.B7GB47"/>
    <dbReference type="PaxDb" id="2850-Phatr30471"/>
    <dbReference type="GeneID" id="7198201"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30471"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_0_2_1"/>
    <dbReference type="InParanoid" id="B7GB47"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="376" mass="40423" checksum="D129D6FD5DCCAD8A" modified="2009-02-10" version="1" fragment="single">MSSSTPVTMSPEALSCVVPGTTPDPRIGDVIAQPRPDGKPFVSLEYFPPRTAEGVQNLHARMHRMRDTLQPAFTDMTWGAGGSTAELSLQLALYAHNTGHVANLHMTCTNLDSGKSSTSTSSSSEHNGNASDDVASADPRETLRRALQQAHDGGIRNLVALRGDPPAGQETWTATEGGFTCALDLVEFIRSLPDIGADFHLAVAGYPEGHPNAISEIADPTTLTAAEAARASVTDGKTYCCLDADYHKEMEYLKKKVDAGGDMIMTQMFFDAAVFLQFVEDCRAWGITVPIVPGLMCINAYAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAFGVEFGVEMCRTLLASGHVSVLHFYTLNLEKVVYGVLDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC07</accession>
    <name>B7GC07_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184635.1">
        <property type="nucleotide sequence ID" value="XM_002184599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC07"/>
    <dbReference type="PaxDb" id="2850-Phatr49837"/>
    <dbReference type="GeneID" id="7198663"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49837"/>
    <dbReference type="HOGENOM" id="CLU_521262_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC07"/>
    <dbReference type="OrthoDB" id="206874at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="523" mass="56842" checksum="E557C980EA2EBFE5" modified="2009-02-10" version="1">MAPFLRFLCSSRQQQRFLVKTLLVSKSYCSRSTNNNWCKSAATSSWISSKSSDSASLAISTASATTPPTAEPSLASDPVLSESTSSSSFVPSLSSWGWTVSSTSPTSYVIAVCLAGVASLALATRIALIDGTGTTTFCERATTARSVPQQPKDHERKDSYIPTSESKQDVDTAMLSSYPNDSREHFILENIAPQAEGTDEEISDQTSQTRSATPLPPNPLADGFSSQTVDELVNEWLQDPSINIRALPDALERQVYRSTVQLTLNAVYRSLASLHGKALLGHELRLRKTSDRSPFEFLSRSHHSTHTIEESVLGQVADRLLQNKAINRPLIPDMVERQLYVNCLKLIFRVLDLLAASLNLTICGHDVFVGLEPAKHQGGAILQDSLNRTTSSLTKLDPEVLREFARQAGVREALSNQSWWQRFWYASQKELLAQLHGSLYSLVLGIVDDILANTSLRLLSENVQVDICQTSEPASPYIPPGGAVVEENLNRANTTGRFLAAFTTGVGVGLATMAALGGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD88</accession>
    <name>B7GD88_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_23830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185010.1">
        <property type="nucleotide sequence ID" value="XM_002184974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD88"/>
    <dbReference type="FunCoup" id="B7GD88">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GD88"/>
    <dbReference type="PaxDb" id="2850-Phatr23830"/>
    <dbReference type="GeneID" id="7198959"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23830"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GD88"/>
    <dbReference type="OrthoDB" id="67021at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="497" mass="53917" checksum="3D14EB5A304B75BD" modified="2009-02-10" version="1">MSVDMSPFLWIAVLGGICGFGYGFFIGANDVANAFASSVSSKSVTLKQAVIIASIFEFSGAFFLGASVTGTIRSKIIDINLYIDEPELLMFGMFTSLLSAVIMLAIATRFGLPVSTTHDIVGCIMGFSIAAKGFDSVDWDVARKLFMSWVASPLISGCVAAFLFGMVKYFVMKTDNPYQRAYYTFPIVLTIGLGIDIFYILYKASSNFSGFSDKLELYWVLPTSFGIGLFAGILWIFVFGPCAKKPEDRKASNSREEIHDLDDSGHPMKESTDEPSSEEKSPSTIVDNLKLLSKKFGDSTYNQDLHAQSMHENPRTAEIWEQGEVYDPDAEMLFSYVQVFTACLNSFAHGANDVSNTIAPLSAIIQLYQDGVVEKKSEVQKWVLAYGGIAIVLGLALYGYRVMKSVGYKLTRLSPSRGASAELAASLTVVTASFLSIPVSSTQCIVGAVSGVGLIGGWKNVQWLFLARVCVGWVVLFFVAVLLSAGVFSFGAFSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDL0</accession>
    <name>B7GDL0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GPI_2</name>
        <name evidence="5" type="ORF">PHATRDRAFT_53878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185232.1">
        <property type="nucleotide sequence ID" value="XM_002185196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDL0"/>
    <dbReference type="STRING" id="556484.B7GDL0"/>
    <dbReference type="PaxDb" id="2850-Phatr16722"/>
    <dbReference type="GeneID" id="7199127"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_53878"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_4_0_1"/>
    <dbReference type="InParanoid" id="B7GDL0"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000060">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="601" mass="66612" checksum="86700A4186A8E650" modified="2009-02-10" version="1">MPPSTATTSWTLKCTDLPQFDALEAEADLFRTDDKLHLRNLCNNSARCAGLTVVYTTPGHRKIVYDYSRQRVTGETIALLFHLADAVGLAERREAMRTGQRINLTEDRPVLHHVLRMPADFHFVRHDPMAGKEGGAQATDGATTLRNVHEVRERVRDFAERVRSGAYKSVKHKHFRNTIVIGTGGFKIGPQFVADALQADPAAMHGSAGRRLLFLSNMDPVDFSTVVGDLDPAETLVVVVSKTFTAPETILNARTAKTWLVQNMAVGGITENEIVGKHMIGITSNPTLCQKFGIRRENIYMLWDWVNPRFSVCSAAGLLPLSIHFSSEVLSEVLNGAHDMDKHFFHAPLGDNIPVIMGLLGVWNSTFLGYHCRAVLPYSHAMRSFPNFVQHVDMESNGKRVALDGSSLLHRSAEITLGEPGTNVQNVLMQLMHQGRPFPADFIGFMEAQQHIHLENEALSNHDELMSNFFAQPDALAYGKTLVDLIQEGIPEPLREHMVFNGNRPSSSILMTRLDAFAVGQLIAMYEHRTAVQGFIWGINSWDQFGVELGKVLATHIRSQLSASRKTGASVQGFNSSTSSLLEHFLAHGKHPEPTSTEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDL9</accession>
    <name>B7GDL9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_51271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
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                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">CCAP 1055/1</strain>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">CCAP 1055/1</strain>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
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                <person name="Maheswari U."/>
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                <person name="Verret F."/>
                <person name="Berges J.A."/>
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                <person name="Choi C.J."/>
                <person name="Coesel S."/>
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                <person name="Jorgensen R.E."/>
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                <person name="Armbrust E.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grimwood J."/>
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                <person name="Otillar R.P."/>
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                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
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    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185311.1">
        <property type="nucleotide sequence ID" value="XM_002185275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE32"/>
    <dbReference type="STRING" id="556484.B7GE32"/>
    <dbReference type="PaxDb" id="2850-Phatr50428"/>
    <dbReference type="GeneID" id="7199227"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50428"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231962_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE32"/>
    <dbReference type="OrthoDB" id="432756at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="504"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="92186" checksum="74F94F68D1FDBDCD" modified="2009-02-10" version="1">MPYCIFSYELTGNRALYLGDGDRHETAFNQYEVVVPFNAYRDPELAANTDGHCRYSLHIYPSQQFAQGYKSSLPIVFTSLVAATFFLMALTFLVYDRFVHRRNIKVVNAAARSNAIVSSLFPSNVRDRLFEDAKARSDVNQAAHSRLKTFLHNGDSSDTAITDENAHHSDFFKTKPIAELFPHTTIMFADISGFTAWSSSREPAQVFQLLETLYHSFDETAKKRRVFKVETVGDCYVAVAGLPDPRKDHAVVMARFAKDCMHQMHSLTRKLEVSLGPDTADLSLRIGLHSGPVTAGVLRGERSRFQLFGDTMNTAARMESNGIRGRIQISQETSDLLADAGKTQWFVAREDTIVAKGKGELNTFWLSVGDVGKGRSTTDTTHSSDDVLAPNNYNSSVALDSLMTTSAESDQQVYNLVSNKTSRLIDWNVDVLSRLIKQIVARRKASKVPKKDSSKQYFCPGDNRGAGTTVLDEVTEILALPEFDADAARRQQDPENIELDDSITSQLQQYVSNVSAMYRNNPFHNFEHASHVTMSVVKLLSRIVAPVDVVVSDGKNQKRSFASKLHDHTYGITSDPLTQFACVFSALIHDVDHSGVPNAQLVKENSKIATFYQGKSVAEQNSVDLAWDLLLDDSFKDLRAAIFATDVEKARFRQLVVNSVMATDIMDPDLKAIRNARWEKAFTASPNMQEDLKDLTNRKATIVIEHLIQASDVAHTMQHWHIYRKWNERLFLELYQAYIASRAEKSPETFWYKGELGFFDFYIIPLAMKLKECGVFGVSSDEYLNYAMRNRKEWEDRGQEVVREMMEKIKGRVKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2024-11-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3R8</accession>
    <name>B7S3R8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_bd1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999269">
        <property type="protein sequence ID" value="EEC42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176206.1">
        <property type="nucleotide sequence ID" value="XM_002176170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3R8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1209"/>
    <dbReference type="GeneID" id="7204865"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1209"/>
    <dbReference type="HOGENOM" id="CLU_001771_12_0_1"/>
    <dbReference type="InParanoid" id="B7S3R8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="23103" checksum="1494B11C1BF318B5" modified="2009-02-10" version="1" fragment="single">GCCETETKTLAVSHAACQKNCFDTEKTAPAARQGASQKGYRKAEKKATTAAANQAACQEGCGDTEKAATAAVSQSACREGCCNTEKATAAASNRAACQEGCSNIEKAATEAVSQVACQKGCCDTEKATTAASNRAACQEGCGDSKRVVLAVDNCCGSKVVKDAEAKQSSVIEKCCSGSKSPNVEIDDLKKGCDGSHLVACESLATSDYSSGHNHAHSHKSVVRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3U0</accession>
    <name>B7S3U0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_bd417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="DS999272">
        <property type="protein sequence ID" value="EEC42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176231.1">
        <property type="nucleotide sequence ID" value="XM_002176195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3U0"/>
    <dbReference type="STRING" id="556484.B7S3U0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft417"/>
    <dbReference type="GeneID" id="7204986"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd417"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S3U0"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="288" mass="32022" checksum="1CE5AC4B7B62001C" modified="2009-02-10" version="1">MSATDCHNIKTVDVLSLDSIRSSLIRQEETIIFALIERAQFRQNEIVYRKGGFGNLGTPVGSTSVEDHDLSFMEYMLVGTEALHCGVRRYTSPEEHAFFPERLPYGQMDALPLLEYPQELLSSVGGACDLNFNKALLQNYVEKIVPSVSKQGDDEQHGSTVLCDIAALQALSRRIHYGKFVAESKYRSDPSGYQQLVDANDADGVMKLLTNRVVEEKVIRRAKLKAATYGTEPLLSEMPPIKGADTTSIVAAAAAVYRDIVIPLTKVIEVAYLFRRCGREPPPEYQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3U6</accession>
    <name>B7S3U6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_bd1619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="DS999275">
        <property type="protein sequence ID" value="EEC42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176236.1">
        <property type="nucleotide sequence ID" value="XM_002176200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3U6"/>
    <dbReference type="STRING" id="556484.B7S3U6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1619"/>
    <dbReference type="GeneID" id="7204892"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1619"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529451_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3U6"/>
    <dbReference type="OMA" id="NCREWEL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="366"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="515" mass="58841" checksum="43C2A752BE1B4E2D" modified="2009-02-10" version="1">MPNFDERAFRLSIEPLELEPVVVKQLRNFVDVVCSMYHDNPFHNFEHASHVAMSVTKLLSRIVAPRFSGANIRNSTKIWESFVLMVASLEAMNWKQLKVKIDPSQTMLGPRIQQLFQDQAQLHDHTYGITSDPLTQFAVVLSALVHDVDHGGVPNFLLVKENEALASFITTRVLLAPEFDALRACIYSDLSELRRFRQTLVNSVITTDIFDKDLSTARKARWSKAFHTLCSDGSQTNEEKQEKLLDEDPSRERNRKAIIVIEHLIQVSDVAHTMQHWHVYQKWNAKLFEELYNAFLLGRSYQDPSLNWYNGEIGFFDNYIIPLAKNLKDCGVFGLSSDEYLNYALQNCREWELKGRELKLEHLLASCRIPPAINQVERHPYLAQPDMMEYCARKNIHVTGYSPLGSLDRPAGLKGPDEVNLLTDPTVTSVANKHGISTAQVLLKWAVQTNASTIPKSIYPTRLAENLMVGRDDFPDLDQRDLEMLQSLDAHRRYVTGAFWALPGGPYTVENLWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7S416</accession>
    <name>B7S416_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_bd477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176320.1">
        <property type="nucleotide sequence ID" value="XM_002176284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S416"/>
    <dbReference type="FunCoup" id="B7S416">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7S416"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft477"/>
    <dbReference type="GeneID" id="7204824"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd477"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="InParanoid" id="B7S416"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9130" checksum="E84DF397555092C1" modified="2009-02-10" version="1">MPVDLLHPSPEQELHTHKLKRLVQTPNSYFMDIKCPGCFQITTVFSHAQTVVLCSGCNVHLCEPTGGKARLTEGCSYRKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7S472</accession>
    <name>B7S472_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176350.1">
        <property type="nucleotide sequence ID" value="XM_002176314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S472"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft144"/>
    <dbReference type="GeneID" id="7204845"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd144"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_1_0_1"/>
    <dbReference type="InParanoid" id="B7S472"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="343" mass="38301" checksum="98558B4AD5788846" modified="2009-02-10" version="1" fragment="single">FRILQLTDLHLGENAWEEWGPEQDRKTYQALSRIFIHEHPNTIDLVVLSGDQLTANNVDANATAYYQKLAFFFEQRSIPFAVIFGNHDDAPLERRHADGTVTIIPSMTSRQQLLQSLQSFSCSLTQSGPSSVPGVSNYVLNVFRDSSAATEGKELSPTLRLVFMDTGGGTLNQTLTKAHQHWFRNQVDLFVNVPHVIFQHIPTAEFQFFSPGFEVPSSHATDSAVACRGLHEDGIAPVTTDFGWLPYLYGSRLPVSLVAVGHNHGNDYCCPYPAKSSRDGLHLCFGRHSGYGGYGSWERGARVYEFSLPVNATSSYNHTFPDILSSLRWKTWVRLESGSMVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4C4</accession>
    <name>B7S4C4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176370.1">
        <property type="nucleotide sequence ID" value="XM_002176334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4C4"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1734"/>
    <dbReference type="GeneID" id="7204876"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1734"/>
    <dbReference type="HOGENOM" id="CLU_394571_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4C4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="699" mass="76071" checksum="A7D32B370711D218" modified="2009-02-10" version="1">MEASTSPRTASKKIGLALAAFEANIDKNNSIGETRSGLYLTNFGGSPKRNGYASNVLLGPQTSPGSWSSPTSSKQTLLKHIAAPDLSLASPRKKEAVETEKRLGKKEKSSDRAGFEVKNTDPSVRVARECGYVSSDDDLSVIVPLADDLSMDSSYAAGAAFTSQTNNNYPPTHFAMRPGTIRGYSFDSDDVDSSQRELSHKSSGGFSMFPGRPSTVRGNSFNSSDSEDLSEDEVQRPNRRAPRRGTRPIKSKGCEKEAREYPHIQSTQNPELHTASPESKSRLVYCPPHQEGGYTEELMHQPLSLQSTPEPPKNKNGIAVVPDKLVASPKDFNSERANSPCARTGRIVVWPPRREDKDSITNARSFIPVVEDPNMAAVPLSPPTTPVLVSSVTLQGRSLRPSAVRGNSFDGMDLEEEEAHAEKRATLRRVVKNSDETRAQDDSCTQLIPSPANEPDTIASKGDQRVDNEVSPVLATDSERSWTAKQSQAHPSSRKPEAFHEDVLSNFADQRRAMLARNPRKPIAAVSPTKLKDRMKAFQFQQSSVSLSTPDLESTRSPNSSQARRVVTNKPGAVPATPTSAPVLEFNEPCVTNFTSPVSVASPITSVDGTASFSSGGDRASPRYTTRDFSNSPTRSSTLHCSPTYPTFEKYRLLPTYEEQHEALLARSPRKEINIDSPTKLKERMTAFQGGGPPSLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0K8</accession>
    <name>A0T0K8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent clp protease ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">clpC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="12"/>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874483.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0K8"/>
    <dbReference type="STRING" id="556484.A0T0K8"/>
    <dbReference type="GeneID" id="4524686"/>
    <dbReference type="InParanoid" id="A0T0K8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF155">
        <property type="entry name" value="CHAPERONE PROTEIN CLPC1, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 12" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 12" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="866"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABK20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="926" mass="103580" checksum="602BA428D72695EB" modified="2007-01-09" version="1">MFEKFTEGAIKVIMLSQEEARRMGHNFVGTEQLLLGVIGQRHGIGAKALKKLKVTLKKARKEIELYIGRGTGFVASEIPFTPRAKRVLEMAVHEGKDLGQNFVGTEHILLALIAESDGVAMRTLDKLNVDIHKLRNLILTYIEETQEEILRPLTQAEKFLLEREKKGSPTPTLDEYAENITKEAIDGNLDPVIGREKEIDDVIAVLARRTKNNPVLIGEPGVGKTAVAEGLAQLILTEKVPDFLDGSLIMALDLGSILAGTKYRGEFEERLKRIVEEAQNDSAVIIVIDEIHTLVGAGAAEGAVDAANILKPALARGKFRCIGATTNDEYRKYIERDPALERRFQPVHVEEPSVGTTIEILRGLRSKFEQHHTLSYHDKALEQAAILSDKYVADRYLPDKAIDVLDEAGARVRLENRRLPLGLRSLMHELQETIKDKEDCIKEHDFEAAKQLLDHEMEVRTHIRIMKQSALTSEARGFSRRDVDMVTETDVSDVVSNWTGIPVTKITGSESARLLKMEDTIHERIIGQKHAVVAVSRAIRRARVGLRNPNRPIASFIFAGPTGVGKTELTKALSDYMFGSEESMIRLDMSEYMEKHTVAKLIGSPPGYVGYNEGGQLTEAVRSKPYSVVLLDEVEKGHPDVFNLLLQILDDGRLTDSKGRVIDFTNTLIIMTTNLGSKIIERESGIKSKTEQGEGGFKITPDAVIGWEPAPEPIKDPEVFERVTKLVNDELKNFFRPEFLNRIDEIIVFNHLTRIDIWEICELMIKSVQNRLKDKGINLIVELSVQAFLTDEGYDPIYGARPLRRAIMKYLEDTLAEQCLSKTLYPNTKIHVRRKKVEGTLMTYTNELEVEVDFSDVDPSLLDEEANETAMSSLDKSNNEKEKVGSIVSKDNSSGINEDEPSFGLGSNDSKPTIAGRAAKFFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0M1</accession>
    <name>A0T0M1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem I reaction center subunit III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">PSI-F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psaF</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="6"/>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria). This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PsaF family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874361.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0M1"/>
    <dbReference type="STRING" id="556484.A0T0M1"/>
    <dbReference type="GeneID" id="4524638"/>
    <dbReference type="InParanoid" id="A0T0M1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.110:FF:000001">
        <property type="entry name" value="Photosystem I reaction center subunit III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.110">
        <property type="entry name" value="Photosystem I PsaF, reaction centre subunit III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003666">
        <property type="entry name" value="PSI_PsaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036577">
        <property type="entry name" value="PSI_PsaF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34939">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT III, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34939:SF1">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT III, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02507">
        <property type="entry name" value="PSI_PsaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81536">
        <property type="entry name" value="Subunit III of photosystem I reaction centre, PsaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2 4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002630245" description="Photosystem I reaction center subunit III" evidence="5">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABK20584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="20557" checksum="43751771D7531FFE" modified="2007-01-09" version="1">MKRFNLITLLFLALLTFTPGQAVADIGGLTKCSESPAFTKRLNASVKKLEQRMSQYQADSPPSLALQQQIDRTKARFDKYSRSDLLCGTEGLPHLVADGRWSHAAEFILPGFGFIYISGWIGWVGRKYVRAVSTTKNPAESEIIINVPLAIKIMTTGYIWPISAWQELISGELIAPKDEVTVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3G8</accession>
    <name>B5Y3G8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_13511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185839.1">
        <property type="nucleotide sequence ID" value="XM_002185803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3G8"/>
    <dbReference type="FunCoup" id="B5Y3G8">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3G8"/>
    <dbReference type="PaxDb" id="2850-Phatr13511"/>
    <dbReference type="GeneID" id="7204604"/>
    <dbReference type="KEGG" id="pti:PHATR_13511"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3G8"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="10">
        <location>
            <begin position="815"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="939" mass="102312" checksum="773A5ACB1666B1D1" modified="2008-11-25" version="1" fragment="single">PWNMSLKLRDLIRKVRQCKTAAEERAVIAKESAMIRTAIREEQAHYRHRNVAKLLFMHMLGYPTHFGQLECMKLTASPHFPEKRIGYLGMMLLLSEDADVLMLSTNALKNDLTSSNKFVAGLALCAIGNLATADMSRDLAPEVDKHLKSPMPYIRKKACLAMSRCLSKCPDMVEDFIDRVITLLKDKSHGVLITVAQLMTQILMIDFRNAEEEGEDPFATPCRQAFLRLVPTLVKMLRNLLSTGYSPEHDIGGISDPFLQVQLLTLLRLLGANNEEASEEMNDVLAQVATNTETSKNAGNAILYECVQTIMGIESEDGLRILAVNILGRFLLNRDNNIRYVALNTLARCIIEQKRSGDMIETGDGEETNSAMSALQRHRTTVVECLKDPDVSIRQRALELIYHLVNDDNVESLTAELLNYLVLCPREHRGDICSRILRVVDRYSPDDRWRVDTLITTLTIAGREAARDVQSSAVVYISRGGEDIHSFATHKLIKAIRDDDGSQHGLLAVGIWCIGEYGDLLLKPYTYTHQASDVANFSSNGGLITFHALDSSSVIDTIEHVAKRHACPEMVKQRALTAYVKLSQRLANSGDQAALDRLRQLLKNQNMSHSLELQLRSCEYSALVNASRGVTASAPAPVTDDIFGMTNDNAGGSVSDGVINAAKEALARMPVIDMKVLQKRLSTSDWDDDSTPRIPRGAAKKDTSGGDLLDLNDIFGAAPTPETTQNGATSVSGAGETGKSDLDLLSDIFAVQAATGSAAAPVSNGTFDLFAAPVSQPAPAPVDPMDLFGQSIPAPPHMSQPMDDLFGSAPALAGPSGVKVSGPSHAGLSIEFECTKPDTFNQQKSVLTAHFKNTSGDTIYGMNLQCAVPKYVTMEMEPPTSTTIPVSGGSSEEVTQKITVTNSMLGTKNLMLKLKLSFTATGERIEHMATASGFPAGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Y7</accession>
    <name>B5Y3Y7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYCH1</name>
        <name evidence="2" type="ORF">PHATR_36892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185745.1">
        <property type="nucleotide sequence ID" value="XM_002185709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3Y7"/>
    <dbReference type="STRING" id="556484.B5Y3Y7"/>
    <dbReference type="PaxDb" id="2850-Phatr36892"/>
    <dbReference type="GeneID" id="7204566"/>
    <dbReference type="KEGG" id="pti:PHATR_36892"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967929_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Y7"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="272" mass="31070" checksum="2B02D457279FEBDD" modified="2008-11-25" version="1">MKHHSSPALRPPFPLFHELDRPGIHDERIRPALCALQVACHVLKVSVECRFTASCLLHRFVAVQVVSIDQDEWQWITMACLFLAGKVEEEPRRLRDAINCASMITIPAQVLNEQETIGDSTQTHEELKTINENLGSFKKVRVQWNSSPPELDDAYWDAKRRIVEKEQFVLRWLAFDVSVSHPHRGVAAIVNHLVDCSPQWFGIVTPEQLVHQAWTHCNDALFSSQALSYPVMTLACAAVSITLRDRNIEESMEEQDWWKHFSVPKDKAASNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y474</accession>
    <name>B5Y474_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185788.1">
        <property type="nucleotide sequence ID" value="XM_002185752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y474"/>
    <dbReference type="STRING" id="556484.B5Y474"/>
    <dbReference type="PaxDb" id="2850-Phatr46921"/>
    <dbReference type="GeneID" id="7204749"/>
    <dbReference type="KEGG" id="pti:PHATR_46921"/>
    <dbReference type="HOGENOM" id="CLU_498284_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y474"/>
    <dbReference type="OrthoDB" id="49001at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="262" mass="29185" checksum="03E372B36F98C21E" modified="2008-11-25" version="1">MTLDGPWKRLYSSALKDGLSFLTLQQALWNYVGPTVLLIQSTGGARFGYFTQVPWKSSTKWFGASPDGPSKDAFLFALEPSWQLYSRIGDSYWQYLHVPSRSRQGILSGLAVGGVAEDSPRLHITATLEGCRACTTDTTFESGPLLGAGQDFTFDIEAMEVWAVQLQHSTDFPACQAEGEMRASIREETRLRFAQVDKSQFVEDFSSGAFMNHVYQHRAQTRGRADFVAADTGELGYYVEDKAPSVPSICDDDYELDFQNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4E6</accession>
    <name>B5Y4E6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185998.1">
        <property type="nucleotide sequence ID" value="XM_002185962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4E6"/>
    <dbReference type="PaxDb" id="2850-Phatr43814"/>
    <dbReference type="GeneID" id="7204254"/>
    <dbReference type="KEGG" id="pti:PHATR_43814"/>
    <dbReference type="HOGENOM" id="CLU_535978_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4E6"/>
    <dbReference type="OrthoDB" id="48490at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="468" mass="51476" checksum="13D16195571B8A38" modified="2008-11-25" version="1">MTETGGLTRAQSRLELLSNTASVMESSNNLLEYHHHPPPATELTVRPTSSSCVSPAVPSEPPALVGVARPSRPPVTFPSRTTVPSLLSSVSLDKETTNHRAHSFDESVAFGTEARFGSNSVHGPQHTTHTHGNHHLIQYSPYKTADSTGTFLEASAHVPIPSLATSRLSLPPHPHTAFRPPHSVGRTRHPLSEGNVRNSGDASIESTLAETLTHRTTSTSSPPLPPHTVSIGDTQNMLRHHRDESPVTREPFGLPRWTQRTTYPSLPNGDRDAASPVGLPSHEDLLRENQDLKQLLHGRDGIVLALQQRVMELERKLQSQVLPTRKISQIPVEDMMNLMREYGSEISDVVMPPRKLSIQKASVVRQFRRWNPNFFEYFSYANGRWEPKLGRQGELARRLQSRNEHALEKKQAEHNTPSSSTTPLASSTPTASPRIRPSNGTHPPPAPSTVTDGSDTFPMPSGDAQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4M6</accession>
    <name>B5Y4M6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186319.1">
        <property type="nucleotide sequence ID" value="XM_002186283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4M6"/>
    <dbReference type="STRING" id="556484.B5Y4M6"/>
    <dbReference type="PaxDb" id="2850-Phatr43880"/>
    <dbReference type="GeneID" id="7204294"/>
    <dbReference type="KEGG" id="pti:PHATR_43880"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549178_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4M6"/>
    <dbReference type="OMA" id="FCERENH"/>
    <dbReference type="OrthoDB" id="6500038at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="497" mass="53391" checksum="1698805D7270152D" modified="2008-11-25" version="1">MAGAWSGSSGWGSSYEALMLRVEANDPTLRDLVILPTKSWSASQVDRLAAALAHGTNTHLCAIHASGHAVPPESLRSLGQAIAHCGHRIQHLAVGDVTMGDAGAQALLDGLTDNGVTSAYAESKSHALLDLSYKGLGPASFCRLVHFCERENHPWSRWCLARNVGLLTSPVGNDIPHAAVLLQRLHELDLSDCDLDEDQCVSLFALDTTSGASTLRSCRLSHNPRIGPRGARAVWHFLLSSSSSSPRLHQEPEPQYGYTNNIQELYLNNCGITDDGMRGLADGSRDERAQCPLRILDVSENQLTSASASSLVHVLSPSCGNPDAHVPFPDLIELNVSQNPLREGVLVLVHQGLVPRHTHSLASPHGTTRLQSLDLSATHCTVPGAHAALSSSHVTTLRLFDNRLGRGPDGWNALDLRTAAPELEMLDLAGNGADQAAVVRLLQVLVDDTDPDTLILPLLKTLVVGGNQGGTDLEDLCAQIRKVRPDLDIARDKIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4P2</accession>
    <name>B5Y4P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_43891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186046.1">
        <property type="nucleotide sequence ID" value="XM_002186010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4P2"/>
    <dbReference type="STRING" id="556484.B5Y4P2"/>
    <dbReference type="PaxDb" id="2850-Phatr43891"/>
    <dbReference type="GeneID" id="7204346"/>
    <dbReference type="KEGG" id="pti:PHATR_43891"/>
    <dbReference type="eggNOG" id="ENOG502RXHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447979_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4P2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045281">
        <property type="entry name" value="CONSTANS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319:SF77">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCT" evidence="4">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="760" mass="84179" checksum="6D16A0C24A01613F" modified="2008-11-25" version="1">MVPSEVQNIAPFSVPSSDTSSVPSSIPSSEPSMSGNDPERYQRWKQESLRHSTPITEKWGWIGADSFDTKKDAKRGKVHDTSWSRLAARFARRSSPIVYRMGVWSVVDWTAAPFSHGNETTSIDQRQPTPPRAELGSYGEFPSIDLPLTIMEDARARFFSSMEGEMEVHESERTSDGLDIDFSITESGRTVAHMVQQDHKTHHDDMDFSITSSGRTLDHFDAIQGENNTAHTNDFKNFHLPEGFSTQHGRHYPASTASNPTPPARSIPIPQPHQTYPPASLLQQIPSSQASSQGSSGSAFLSSMLNQGPLSHTPPVASSYEVSHFGKRARSGSVSGRLRSASDYLEEKGLLDRQTKGILKDLIIIGDEELQVALDRYEAGDPSTLERMISSGALEERLPKDLDILGDLDLDFLTVHDDGLDLTGGDSIEPLLPSAESYHQHASQSQSLSANGGSYRHRQAVGPGQAPNLVSPAYDDGIGDLDFSGEFVEQAEFGFQPQSYGSSKQASVAASPTDHPNNMMSEYERRMRSNSLFSALLDPRGGGNSSVNTATAAVASKHGSSETDRTDGGLDYGQWMDRTLANNAKATGIQIGHRRSSAPASSVRSGISASLEQADRKKQDKKDRKEQKALEKLEKKQRKEEEKEKKKQQQQQAVEEEQMEEEHVPGSGRPRALSDPNLHTSLDQHGLMNVTRPDGWVGAYSPESRKVRVDRFMEKRNHRVWTKTVKYDVRKNFADSRLRVKGRFVKKEDELLMRELMSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4W9</accession>
    <name>B5Y4W9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_43960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186081.1">
        <property type="nucleotide sequence ID" value="XM_002186045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4W9"/>
    <dbReference type="STRING" id="556484.B5Y4W9"/>
    <dbReference type="PaxDb" id="2850-Phatr43960"/>
    <dbReference type="GeneID" id="7204182"/>
    <dbReference type="KEGG" id="pti:PHATR_43960"/>
    <dbReference type="eggNOG" id="KOG2074">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028711_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4W9"/>
    <dbReference type="OMA" id="HNSTLVL"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="641" mass="71731" checksum="6ED37842C83C09DF" modified="2008-11-25" version="1">MTMREAMDVDSVETSYTPVRYKKQSGSLQLSTSSLTFLGEGSSKVVKWMHIAKHQVSPASYPKPLLKIVLSSGTNLTFQLPDRSALDQIRLDVTRRLQFRSSLSSSSPAGGSRKRPLTDLSQTSTFGDLDPTALAVTRSALLAAHPSLRQQHQQLVQESETLSEEDFWLTHKDLLEEEYARISGLAKAGTSSLLQSHLPTAGKVTLGVEEMRQIFILYPAVHKAYEEKVPLELSDEQFWRKYLESEYFHRDRGRMGTAAQNHSAIETKTAKSKDGVKGLSMEQQDARAAAVGTDDLFSRYDQKLSQENGENHETSHRRWGRQLAVGQFDLASTFETERGKVLEQANRDNHPPNIADDGRGTRVIQKYNRHWAMVLHPEDAIAGSDLMQVARKSVRDVLPGDDDAAAGGGFDQETRRLVKYAEASTEAANHASCLGEDEGAYEPLTLSNVEAYYSGQLRNGHTAENDEEATKRHIVLARMVSQKVGKLVDSLEKNFDLPESCFPPPSLGRELLSALTRKMAQDSRTEAASLEMVNKLPEDFRKRLHSHFRRSSELLRHFFGLRRMEAANAGNGQKLSRIVLAMESFYREMESMRRELPQTETGEMMRKMCLPIMDQLDWAFKLHREGSGGGVGGGFVAVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y537</accession>
    <name>B5Y537_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186402.1">
        <property type="nucleotide sequence ID" value="XM_002186366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y537"/>
    <dbReference type="PaxDb" id="2850-Phatr33369"/>
    <dbReference type="GeneID" id="7203987"/>
    <dbReference type="KEGG" id="pti:PHATR_33369"/>
    <dbReference type="eggNOG" id="ENOG502SGK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607613_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y537"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="30794" checksum="B40ABFA0B439CEAE" modified="2008-11-25" version="1">MSLISMIPLELRKRRIERAVLTQFGDQLDDAALRELATGPVIQRLHLSANRPDGLDECTREMFSLAMLVRLGKVSDRDIKQTFAAFQRLDLNDEGVLNSKSIIAAMIQKRRLVKQNQQFLQASHLPYQPPPPPPFVAPPLPQHVQQDPIGSMPLGHNKDMQHLWFGQRGSMHVDTAEGHHYRFQRPEFVPTEQSALLPHYPTHPPQLVHQHQYQSPAFPPTYAMPQSPLYRYAEPHGIVPEFAPRSYQQPHQSRWHDRNRMTHESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y553</accession>
    <name>B5Y553_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_4821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ACI65593.1"/>
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    <dbReference type="eggNOG" id="KOG1344">
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
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    </dbReference>
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        <property type="entry name" value="HDACs"/>
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        <property type="entry name" value="His_deacetylse_dom"/>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF19">
        <property type="entry name" value="HISTONE DEACETYLASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="324" mass="36054" checksum="898DA3E9994E59CB" modified="2008-11-25" version="1" fragment="single">PIVYHEDYSFADWPSLHTFPMDKFARTAHALLTTCKATYPESSLPRPLVRQELDFFRPLDFGDVPRSWLSGPIDSVFVDRFLNAQLSHEECRVIGFREQTGRTELIRRTVLEVAGTVLTSQLACRYGIAAHVAGGTHHAHVTGGAGYTIFNDLAVATHVVTATEPSVERVLVIDCDVHQGDGTARFSAAPDGPLHSKLYTLSLHCASNYPRLKAHSTWDVGLPDRMEDDEYMDALVRAVDVALAAAQPDLVLYDAGVDVYRKDKLGRLHLTLDGIRRRDRWVLDRCVSARIPVAAVVGGGYDRDVDALARRHAIVHEEASYVWR</sequence>
</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186441.1">
        <property type="nucleotide sequence ID" value="XM_002186405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5C0"/>
    <dbReference type="PaxDb" id="2850-Phatr44098"/>
    <dbReference type="GeneID" id="7204031"/>
    <dbReference type="KEGG" id="pti:PHATR_44098"/>
    <dbReference type="eggNOG" id="ENOG502SFZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316762_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5C0"/>
    <dbReference type="OMA" id="VYHESAH"/>
    <dbReference type="OrthoDB" id="193078at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACI65911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="820" mass="90956" checksum="78F49922B9AC5877" modified="2008-11-25" version="1">MPIRSDGKPLECQKSRRGSWSSDEGSHPDHKNCKSSSATLDPPILVYHESARSIVFRDHLRRAVRRSESSRSDSAGIEPTVPSAVVAQTPSNQAANKKMDHISQCHTNLDPLTAFVENVEEEFGLKKAVIPAKTTIPPTEQIIGFLPKIKPLPPMLLGPNDQFGLLLNAPDGLTNPAPDDWTADEREVVELLRTQHACVKTLKNADWTPFLRRFCFPLPTRGTKPKSHDDIPPDEEHPFNSFVTSTTMLPSLGLKMRAYGSSTQYTTGVVFAMPRVFPDDDTEDEAQARTETWSWPAGYSAKTEFNIDSRGRLMNGRQEALRPFSVLREYNNDYITKSEYMISTRMVSGLSVIPYNEIFIRVGGFGRIVNNKDVASGKDCSEGGGIGRSFCRGIGLPIALFVRTATYGHLISLLRTRSRIVHAFGEHHVKGIPLLLIDPDHGVRVLTENMQLELWKIASTNLNPFQNPAIAYKTTLENTEHVSFQQKVDELIDLDESIQDKLTPGELAHLAGGFGATDESVANILKRVMMEDRRKNKKGEKEESHKLQDVVNEGLTSAVRSGDYHTSRQLLILYSLVACRAGQIIDEDDETSEDSETEKGECNTNWVGARGRQSSMGNDVDIMRRDIELVSKAKNGTKLSSGILAPPPPPPLDTDRLRSATNSDGLLAVLGAAQVLKSMQDGSAKHRTLEAVSAIEEWVTYGEQNMAFRISSWYDQRAAQGDLKIATEDKTSFLAFVSNKAITNRKSFAQKLRSAVSSTDFTDIHFLRGIYEILGHMHSPCLRLELLQYVLGLDNRYSVAHVARSVELAATCLGISMEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5U1</accession>
    <name>B5Y5U1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoadenosine phosphosulphate reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_25956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophycidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186247.1">
        <property type="nucleotide sequence ID" value="XM_002186211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5U1"/>
    <dbReference type="STRING" id="556484.B5Y5U1"/>
    <dbReference type="PaxDb" id="2850-Phatr25956"/>
    <dbReference type="GeneID" id="7204140"/>
    <dbReference type="KEGG" id="pti:PHATR_25956"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627736_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5U1"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF2">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838423" description="Phosphoadenosine phosphosulphate reductase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="272" mass="30837" checksum="B55B976668467EE6" modified="2008-11-25" version="1" fragment="single">MKYLVAVTTLLSTVSVSAFVPQKAAFGALTPFGSRTGVKMADTETIFDQEQYIAESKEMRLKHLEEQAMFALKIAVENYGNAVFPNAMIAGDVVITHLLSRLGYLENGKAKIMVVDTFHLFPETMEFLEKLEEHYNFKADVFCADKIPVGDKDAFDKRYGANLWKEDIDEYDRVCKVEPFQRGLKTLKTDCMINGRTRWQGFERAWIDLFENAPIGGGLAKCNPIAYWTLEDTFDYIAKYDVPYHPLHEKGYPSIGDAKDTIPVPEDGSVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5W3</accession>
    <name>B5Y5W3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186259.1">
        <property type="nucleotide sequence ID" value="XM_002186223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5W3"/>
    <dbReference type="STRING" id="556484.B5Y5W3"/>
    <dbReference type="PaxDb" id="2850-Phatr43788"/>
    <dbReference type="GeneID" id="7203936"/>
    <dbReference type="KEGG" id="pti:PHATR_43788"/>
    <dbReference type="eggNOG" id="ENOG502SA27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474524_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5W3"/>
    <dbReference type="OMA" id="AIVQTPY"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="482" mass="54273" checksum="70CF94250B705E2F" modified="2008-11-25" version="1">MQEHGGHVPEDKVQYLVKTPYGRGLVVRSRIDPHLDGTIKSRELELLDWKNLPSENDTNSASAARLVRSGPVRPATLFSSADFPSIDPEEQNDVETPYGRGRVTAMRPETNQVVVRISSWRLAGRSTVTCHLNKNVVNVVRSKQIYEMSTIEKIEYAQELKQEANRLFSGKRYQDALQFYAKAVDAVRYVQHKADSTNEMRADLLVVMVTCSNNAATSCTKLHQWDEAEKFARNALVLMDALEDKHGKRIHGILLKDGFPDIKLFGEWRVKSCIVIARALAEKSSTEDAIASLKKAHSFIEKYTGEENIKNTSLQSSIKQLQSLEREIKKLHKACLERRKVERKMERKRAQAMFGAKNATPKEDEKKDGNFSNNPSKLPKLSAPGLEDGNPVTKHSAKTCSPSIRSVRSDVSEKSTQSLRGDLKRRVSFATKIDDRDDDKDAASDVLEWYQDSEVLIGLAIFAGMALTTFVGLNYFLFSPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP30</accession>
    <name>B7FP30_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_8663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177144.1">
        <property type="nucleotide sequence ID" value="XM_002177108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP30"/>
    <dbReference type="STRING" id="556484.B7FP30"/>
    <dbReference type="PaxDb" id="2850-Phatr8663"/>
    <dbReference type="GeneID" id="7196318"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8663"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_935270_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP30"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF62">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20244" checksum="8E5158DB4968C1E5" modified="2009-02-10" version="1" fragment="single">LPNFITYTRCLAIPGLVGLFYVPGKHVETGSLFAAAAFTDWLDGFLARKWDISSSFGAFLDPVADKLMVSTSLILLSGRYGSRVAIPTAIILAREISVSALREWMAQRGQRDLVKVGFQGKLKTAVTMATLTLLMLIPFGEEVGILGKEVVLKAAFSFLYFCAGITITSGSVYFRAAIPVLLKANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPJ9</accession>
    <name>B7FPJ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_9147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176727.1">
        <property type="nucleotide sequence ID" value="XM_002176691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPJ9"/>
    <dbReference type="STRING" id="556484.B7FPJ9"/>
    <dbReference type="PaxDb" id="2850-Phatr9147"/>
    <dbReference type="GeneID" id="7196157"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9147"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_755384_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPJ9"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15393" checksum="5B9DE8B67BA8F015" modified="2009-02-10" version="1" fragment="single">IQRANTDPVVWIVPGFLSESECDALQRKASRRMTSCVTKNADTSRVYKDLSRTSTNTNVPRREVPTVVSKLKNLTLCDDEARFEILQVLRYQAGQHFSPHTDGFSGPITACGFWDSGRLVTVFCYLNDVEKGGTTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPP1</accession>
    <name>B7FPP1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_50671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176747.1">
        <property type="nucleotide sequence ID" value="XM_002176711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPP1"/>
    <dbReference type="SMR" id="B7FPP1"/>
    <dbReference type="STRING" id="556484.B7FPP1"/>
    <dbReference type="PaxDb" id="2850-Phatr50671"/>
    <dbReference type="GeneID" id="7196483"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50671"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPP1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="64"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="407" mass="44473" checksum="05EFACB273678C87" modified="2009-02-10" version="1">MGVMEKIKEIEAEMARTQKNKATNSHLGLLKAKLARLRNELFVEQSGGGGGGGEGFDVARNGDARIALIGFPSVGKSSLLNSLTTTESEAAGYEFTTLTCIPGVLRYKGSKMQVLDLPGIIEGAAHGAGRGREVIAVARSADAILIVLDAGKEGLQKHREILERELETVGIRLNQRAPDVTLTKRKAGGGVRFASTVPQPLLGVEPEKLVTQILREYRITSADILAREEITVDQLVDVIQGNREYKPCLYLYNKIDTVTVEEVDQLARMPYSIVGSVAQGFNISGPFEDDRLKQMMWDYLGLTRVYTKRKGSPPDVDEPVVLSEIRKGTTVKSLCSNVSSELLRDFNYALVWGTSAKHAPQRCGLNHILDDEDVVQIVSKTPHSKPARVADRNRMATSHLTDAKPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPS8</accession>
    <name>B7FPS8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="2">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_31948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177266.1">
        <property type="nucleotide sequence ID" value="XM_002177230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPS8"/>
    <dbReference type="STRING" id="556484.B7FPS8"/>
    <dbReference type="PaxDb" id="2850-Phatr31948"/>
    <dbReference type="GeneID" id="7196444"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31948"/>
    <dbReference type="eggNOG" id="KOG3099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034742_2_0_1"/>
    <dbReference type="InParanoid" id="B7FPS8"/>
    <dbReference type="OMA" id="QTEADRC"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="33933" checksum="8499181039D097DC" modified="2009-02-10" version="1">MQQINEDACVRGCHEIRDVQEERDQGSSFHVEFKDSSDPRSALTEADSRAQKAIVAALKQDWGPELRIIGEEDPKDGFLSVATNKTALRINLCSSIFKEDCDMQTLSDIIVFVDPLDGTREFVEGRLQNCQVLIGISVGGIASAGAIGIPFPTGNLDESPTVVYGKVGLGHGIIGSPLPNAHGRIPLSQPLLATGDTILPIMAEARRIVQEHFGGINCLYGGAGNKILAAALGLVDCTIQHKFGGPWDTCAPAAVLKSMGGEITDLLGEDLSVYQEGEQEQSTRRGFVATGRNSLIPHKVLVAALQESKRITTYING</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ64</accession>
    <name>B7FQ64_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vesicle-associated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SybA</name>
        <name evidence="12" type="ORF">PHATRDRAFT_17683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176826.1">
        <property type="nucleotide sequence ID" value="XM_002176790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ64"/>
    <dbReference type="FunCoup" id="B7FQ64">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQ64"/>
    <dbReference type="PaxDb" id="2850-Phatr17683"/>
    <dbReference type="GeneID" id="7196789"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17683"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="InParanoid" id="B7FQ64"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25756" checksum="E661DAF9820F3830" modified="2009-02-10" version="1">MTIVYALVSVGKTVLAEYTATSGNFPTVTRVLLSKIPSQDGRMSYAYDEFLFHYVVENSICYLCMSDEPNKHRIPYACLQDIKQRFVAQYGLEEPLTANAFAYNEDFSKTLEVRMNFYNSTDAESSVDNIGMVKSQIDEVKSNMVENIEKILERGEKIELLVDKTDRLNQQAFRFESSSRNLRRTMYWRKMRCYAGAGVAVVFLIFIATASLCGGLSFHSCRRQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQC5</accession>
    <name>B7FQC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_43016</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177376.1">
        <property type="nucleotide sequence ID" value="XM_002177340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQC5"/>
    <dbReference type="FunCoup" id="B7FQC5">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQC5"/>
    <dbReference type="PaxDb" id="2850-Phatr43016"/>
    <dbReference type="GeneID" id="7196229"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43016"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="B7FQC5"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="94"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="776"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC51839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120020" checksum="0A3ABC65B3C76286" modified="2009-02-10" version="1">MSEEPPVGVNPNAEDETPAPEGEKKLSKNQLKKLAKGKDKKKKDKPQWNAPSKEKVKAPVATTSFVNTTPKGEKKDLSAPMDAAYHPSAVEAAWQDWWEKCGYYSCDPKDAVDRPVDEKFVMVIPPPNVTGSLHLGHALTAAVEDTLTRWHRMKGHATLYVPGTDHAGIATQSVVEKMLMKSEGKSRHDLGREEFVKKVWEWKKDYGSKITNQLRSLGSSVDWSRERFTMDEMLSKAVVEAFNRFHEKGLLYRADRLGNWSCALKSAISDIEVDFIELEGRTFLDVKTHKGNPNDPNGRYEFGTLTSFAYPIEDSEEQIVVATTRLETMLGDTAVAVHPDDPRYTHLHGKHLIHPFNGRRIPIVCDKELVDMSFGTGAVKITPAHDPNDYECGKRHELEFITMLTADGSINENGAPFTGMMRYDARIAVEDALKEKGLFKGKEPNKMRLGLCSRSGDILEPMITPQWYVNCDGMAKRATDAVRNKELTILPEEQEKTWFHWLDNIKDWCVSRQLWWGHQIPAWFATKKGESLEKNDMANNDRWVVARSAEEALEKAAKLLGCPAGDISIERDEDVLDTWFSSGLFPFSVMGWPDDTSDLKAFYPTSLLETGLDILFFWVARMVMMGLELTDTLPFHTVFLHAMVRDKEGKKMSKSLGNVIDPLEVINGCSLASLQERLEGGNLPAKEVERSKKNNELEFPDGIPECGSDALRFGLMAYMVQGRDINLDVKRVVGFRLFCNKLWNATRFALQFVADFTPTPTLLDDLMASGKMATRDKFMISRLMKAVEAVNDFFSSYRFGDAQQAAYALWIEDLCNTYLELIKPVVYDMSVNNIDNRWAAQATLWIAMETGLRLLHPMMPFVSEELWQRLPGRGTLGKTEPETIMLAPYPETHNSYKNEAVEQSMMNTMAVVNACRSLRQSYNIANKVQTHFFVNVSGLALHAVLDQLDDIKTLGKASAIDINLSPADTPETVGTAIVNDQLTVLIDLQGLVDYKVEIGRLQKNLRSTLPTISTLEMKMATDGYTENVPNDLQKANLEKLDSLLKKKCDLEEAIANFERLALLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQU5</accession>
    <name>B7FQU5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177466.1">
        <property type="nucleotide sequence ID" value="XM_002177430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQU5"/>
    <dbReference type="PaxDb" id="2850-Phatr43160"/>
    <dbReference type="GeneID" id="7196762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43160"/>
    <dbReference type="HOGENOM" id="CLU_529450_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQU5"/>
    <dbReference type="OrthoDB" id="38164at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="225"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="490" mass="55509" checksum="CAEB1CD67B41AF80" modified="2009-02-10" version="1">MTDSTHHRAMSSINDFTLLELDRPDHGNGDGTLKELSSTSMIPRSTLVIVTETEKLHEDPTHGRSGSSTSLVASLSDFDFAFSKLQVKDWDMQTFYSDYIQQGREYLKETNNNVIMLFESPSSSTADSSFHNKTKYKFHDWPPPVSTRSKGILGPCRYALMNGTSYPAFLRDGQAPDGLFAHWQKTVPGVVVPTLVPKVTDNDVVYAYLPVEQIQHHVNDPNTHYHLAGKDAIHLMTQKTTKLLPDTRTSRPCVVKTTHSMGSKGIFIIRNDDDEAEFEQFLNDSGHPTFVVTDFVDIARNVACHFFLHPDGEHLTWFGSNENKRLPDGSFSSDSYLEWQDQEKLKKMQLPFVEEVAQYCKSLGFWGFCGVDVLFDSRGRGYLVDINPRVTGSCPALMTLQLLRDKYAFTLGLFRRSGDINYYGDAQSLWKQVDEYNFANEGKIRIVIHSMYEAETGDRVRINIGVYGTDMEDCKAVLNQFAEPKREESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQW3</accession>
    <name>B7FQW3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_43176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176938.1">
        <property type="nucleotide sequence ID" value="XM_002176902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQW3"/>
    <dbReference type="STRING" id="556484.B7FQW3"/>
    <dbReference type="PaxDb" id="2850-Phatr43176"/>
    <dbReference type="GeneID" id="7196769"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43176"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589850_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQW3"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
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        <property type="entry name" value="Not2/3/5"/>
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    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="328"/>
            <end position="437"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="464" mass="47487" checksum="B1CD70EFBCB73F9E" modified="2009-02-10" version="1">MEGASTTSSATSSVDGRSAGGGTSHNTTASASDYLNIGMFASGNTPGGSDLLGNSNAVFLGNGFGNIDSTNTAAVSALVNSTGTSFDLTDFPSLAGGIGGANASVAGNGLAAALRQQQQQQQQQLLAHQQMLQSKGGVSNASNLYRLAMSGANGNFNMATEDFPALGANAPQPAPSGSSALNPSSLLSGSMPVSRGGNANGNVGGLYADIDTNKNNTASSGSQLDVSGGLLGGTGLGGLGGIRGLQQAGMTGAGNAMGRAPSSTVPGAGAIGSSSSGGAAAGGALTGDYGLLGLLGVIRMTDDDRNTLALGSDLTMLGLNLGSTEQIYSTFSSPWSDNVATKEPHYQLPVCYYMQPPALKTGHLSKFQLETLFYIFYALPKDVLQAYAAQELYSREWRYHGELKLWFKRASPSDGVSSSSSGSPQYLYFDINSWERRLFNGSMNQNITSGFITEDEVQVKFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR02</accession>
    <name>B7FR02_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176958.1">
        <property type="nucleotide sequence ID" value="XM_002176922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR02"/>
    <dbReference type="STRING" id="556484.B7FR02"/>
    <dbReference type="PaxDb" id="2850-Phatr43211"/>
    <dbReference type="GeneID" id="7196575"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43211"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR02"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="640"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="826" mass="92452" checksum="3C63A42A4EFD50D3" modified="2009-02-10" version="1">MSRPPSNFSRFPHGAPQMGGRGPTHFGRGSRERPFMGRGAPPPDRPPFVLGSSGPMRNGPHPGRGPYGSASGPPMMSGRIPGRGDARGGATYTMHRRPLPGRGPPPPPPQPPQGIRAGPGPTLGRGGRKEGTYPQPGSFQHWPPGPPNGMGNRIPPPPSRTDPAVRERPLPHPPYPTNHSVGLSPGPLYSRPNGMLPPPPPPPAIIQHHRETHSTMPVSIIGRAPPPAMPHQHSSHFINGKVGLSPYHRPQPPPPYPPAAASTQQQPQAAPLQSTWNHPSLNSTPRNSHQLPLPTTSPAIVAPLSEDQAWTEHTAPNGMKYYYNSVTKASAWEKPEALKKAQAATTKPRPWTQYTDAGTGKTYYSNGITTSWEKPADFEPVDRRTTATATIEEVSSEPPQKKKKPEKKNTNFASKDEAVAAFKGLLLAKDISPIMKWSDVVKVVSSDSRWENCQDVLTIGERRQSLAEYQTKRANELRTLERQERQRSKEAFQQLLAEVLPTVSGFSAWKSRFHEFRDSLAKDDRFHAVADDATRDSLFLDFCEESRKRDERRKRNKKREAEESFIMFLKEKQEIGKLTFASTWNSFASLLDELEHNDARFVASVELSDADRQLHFADFVLELQTSEDDKRRRIRDARRRAEKAQREAFRTMLQHLATEGKLLPSSRWRSVEELLTTDPSFAPVQEQDRDAPRELFEDFVDEWNELYRRDRALLSRLVNSKSDNARKLLVTSTMLYDDFVNALLDEAADSPEIYGEVKAIIFHEVPVSSARLYFNELHFRAKGIARPILRLPHQREEDSSEDEGEIIEDGEAPESVNQLARDASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR32</accession>
    <name>B7FR32_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176974.1">
        <property type="nucleotide sequence ID" value="XM_002176938.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FR32"/>
    <dbReference type="PaxDb" id="2850-Phatr43236"/>
    <dbReference type="GeneID" id="7196957"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43236"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251251_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR32"/>
    <dbReference type="OMA" id="HEVCERI"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="225"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1452" mass="162992" checksum="F5CBE1E6A1E43BEC" modified="2009-02-10" version="1">MGLLAELDRLVESDYRVEINALEADKKLAEIALVTGLSVRDLNIKNGKPVFRPPTSKLEVLASWKKLMAVLKKHEVFLEYLKSLREAFVQFSAIQSLEFRHLKTLISLLSHTAENSQRDNSTECRFVTLLEVLLSYGNGWQPSEQITRFWVRLMQRIPADVPKVNFRRKAYRVLVSLSWVPSSKGLLGACSFEDNRQILDSEKAPAAVRGHLKRIRNTPLPRYDCVNQLLDRLKDETDVCVAIRSELEGTGKTTLAALVASHPSILRVFRVLWLPMDQRDVTYTAYAKLLSNLCDQLGVAPSWPEYVTRFEEPALRQLREKEYMEEARAQMSEILLNVDENILLILDDVQNASQIKNFRFNDRQSIIVTTPDPNLAGVDWTVELDPMSEEEAIELFLAEADLPPAHILGCTDEMKAIVRKCNCHPLTVRTTARWYHLKQVTAGLPKAMEELVIDVNRISMLTSVAASKYVGNYQILFGILSQMLSPARNDGQGSSSLFILCLAAMVVVFPDRVPLDSVLLLWNQLMQNKPQAVAELGLEGEPLPIEIQKHAWLIAEGLTHLGIVSVIDYQNTAWVEAHHNLYSRLAVHLAEEMNFGVSEAFEDIAEEWNRAFVTSYFVHRIQSGDPTDDDSMAYAIDKLPDHMFRAKLFTVGETILVDENFFHARIDALGWDEAIEIHVKDCVRLQRAIEADDETGSAVIIASPVFARLSALVEATAMGDQSPNNSTIIDVSSALFQVAFALAETGFFEEALMQFDRAQRLLPHSQPLCASILYGASWTLLASGEIEQASKKIKACRKAMNDCPGIHVLFTETLQLMADIWVADCEYKPALECLDELIEVLMGSLPRSRIELGTALYKKGRLLFSMGDLELARATLHDSLNWKVEIGEFSKNRAAAYSTLGDLLMETRQLTVAKEMFENAIVTFDALETSSDSLDRLLVTGKLRFLQGNTQGGLKFLKDAHKSIQKLPILLMDQSAYYLRSIARVYQDSGETAEAIGILYESLSLTDSRPLSIERSAALFDLGNCSLDQEKTSEGLTYLEESLKIRVLKLGECVQVLDTLKLIGSVYMSLDDYDQSLKIFRKVHEVCERIAGSEIERIAGALYSIGEVYDCLGLFDLAMDNFTECKLVLERGREKDHPDIAKALHRLGDLVASQNNLDKAEDYFSEALRIRRMNFDDVLLAESQYSMGVILRKLGRLEESEGFLVDALETRNKLECNRETGQTLLEIGNLYRLQGEPANAVSLYEKGKEVLGNESDLLGSVYLASGHAMVSLERDEEALLCYLKAREIRLGAYGKDSAKYGNACRSLGYINYLLRNVDEAIVCLNEFVRIYEACAEDEREDSSENFDYALGIVLLGDLNIARGKPDQARKLWIVAKEIYEEDEGLTTQLPALVDMVQRRLKGKELTPSSPGKGLLSRFHGAVRLSEESTLKSTLELDPKEVGILRNIAFIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRR6</accession>
    <name>B7FRR6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177849.1">
        <property type="nucleotide sequence ID" value="XM_002177813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRR6"/>
    <dbReference type="PaxDb" id="2850-Phatr43287"/>
    <dbReference type="GeneID" id="7197064"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43287"/>
    <dbReference type="eggNOG" id="ENOG502SSNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513378_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRR6"/>
    <dbReference type="OrthoDB" id="54544at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="58804" checksum="6B003EE878E8D1AA" modified="2009-02-10" version="1">MGSGNDYSSSKGTRSSIGRRQSRLAMSKLHEAVPKSPTHVLMDPSVTKLALDDRMRRDYLSQRFQAYQRARPPKNNSEIPADEEFWCGATSVERSLVQCCESSRGVADDDDVVPGALAKDKVLRFVGLVAAHCHTLVTRSISLNILERGLEADEKDPPIPVEPKDESPETAAKTTRTTRLAASHSASPEAVASADEHAVTLPSIPTWMEYARITSFLEAGGLRLLSQWLVDCTTPGPTPPPVKPPPGSKPPTRKEPAPPVYSKPSATSPLLLPLLIFLRRIPFNRQAVTESKINKHIRRISKTVNIIVKQAQDRSASSRKPPIAQVTDILTGPTPIVEVQAALNELKETWEAKSQAATAFAIPLDPFAALRAQIQERVSQVAQFEKGEISRPHWWTNEPTGAPAKKRPRISTEQMARKERENEKAALMRESLKQAAAERAKLLKKLRELKHKQSEGMAHESKHLMRRRVQWKDAMGPTSLQRNRAVLEEVFIFTKDKIESKESSATAMPAEAAESSSVETPTETETSDIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRX8</accession>
    <name>B7FRX8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_43342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177877.1">
        <property type="nucleotide sequence ID" value="XM_002177841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRX8"/>
    <dbReference type="PaxDb" id="2850-Phatr43342"/>
    <dbReference type="GeneID" id="7197395"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43342"/>
    <dbReference type="eggNOG" id="ENOG502S2UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_22_1_1"/>
    <dbReference type="InParanoid" id="B7FRX8"/>
    <dbReference type="OrthoDB" id="2017960at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF5">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855349" description="EamA domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="47749" checksum="F1BE5E74FEDC7BAF" modified="2009-02-10" version="1">MSSFKRQISLCHFLLITLLGSESAAEAFATKAQLVPSTRARNARHHATVPVLLRSIREDSAEITKQPGSSDSGRIGFEDSAVSRYLQSKLAVTDETVGLLVLLTVPVVWGTYVPVVRFLYEIDPPIPGFVFSVCYFALASLTTLSMLAFGNTNELFRSQPTNSEPIGSLGREEDYPETSAVFDMPILGGLELGGYLFLGNCLQVVGLKTVSADTAGFLVQLTTILVPLFSAITAGNLFSVSARTWIACLIALGGITIMGIDLPERVDSLTSLLASFSTPTVVPSLAQGEYLILAAAVSYTMHVVRLGQYARYTTPLKLAAAKATVETVLSGLLVLVLVLVAGDGSSTATGVLGYAQGAGREITAFFADVQERMAEGTLATSSIQKAVGATMWAGWVSTAYVVYAQSFGQQRVGASNANLIYSLQPIFTALFARRIDPLGGLAGCLGPFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS65</accession>
    <name>B7FS65_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177927.1">
        <property type="nucleotide sequence ID" value="XM_002177891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS65"/>
    <dbReference type="PaxDb" id="2850-Phatr43420"/>
    <dbReference type="GeneID" id="7197432"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43420"/>
    <dbReference type="eggNOG" id="ENOG502QPN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365046_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS65"/>
    <dbReference type="OMA" id="IDWHEAS"/>
    <dbReference type="OrthoDB" id="38640at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855259" evidence="2">
        <location>
            <begin position="23"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="765" mass="83770" checksum="190A319BAE66380A" modified="2009-02-10" version="1">MIRSRDVVAIVAIVLLSRMAWRDPAESSLTVTTFLSFYVPWQEDRGRGAAAPTLLDVDGDGVSEALVTIVQTTTGDVANGNAWTIQILDLKPAANTDQTHLAPFSPKLMYASSSMSMEDTHMSPLMITTGHVLSEAHVEAKPNGSDNPSKQNSGGDRTRHYYCGIDWHEASDKCGKHCPKGQADECPPGEKCYADTPCDASADEQHRSILDEKDMYQTPVGSVPTVFVLWNDGSVSAHSLTGEISAGAKGLELTHLWTRNVYREKNRTLTDWEDTTLNFFNALDAGDAHGKLVFTGYIDFQTPDDDIESAKIAVALDAKTGQTQWEFFVPDDGEVLDDEAPLLLPLKRGSTSPARRRSQIPSLVALHESRGVANCLHAYRRSLLTTGVLPHSYWSNDDATVTAVHFTHQKMPAEAKLKGKDKLKPKMGGGLSKGITIKPKQTLSAKLLPTKKRRRKRLPHFGRPNVLVLHNQHGIHVRSIKNGMSLCHVSLSDDTLYADLNHDGVLDSVQVLVGGHADNLEDSTDDGYKFVSQLVKRVGDLGQEDAKVEIASRNRVRSRLCHAMALSGIPTKEELFSVSLCSNKDDRDESIAGSPPLAIESLNGKGYDLIVALSNGQISRFRGVSGSRVWQISGRRFEDFPTWDDTTLVSIDRIEAEFAQPATRPILIAGENSMALLASRKGTVLATASFPQPSMRKPLLMDFNGDGTTDVMVMTQDAIWGYRVVVKTGTSILFRITVGLLLVAMMMAVLRNRFSPQPGKRSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM0</accession>
    <name>B7FSM0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_43552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002178005.1">
        <property type="nucleotide sequence ID" value="XM_002177969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSM0"/>
    <dbReference type="PaxDb" id="2850-Phatr43552"/>
    <dbReference type="GeneID" id="7197582"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43552"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305556_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        <location>
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            <begin position="452"/>
            <end position="899"/>
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    </feature>
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        <location>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC50819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSN5</accession>
    <name>B7FSN5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hRad23</name>
        <name evidence="9" type="ORF">PHATRDRAFT_43564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEC50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002177976.1"/>
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    <dbReference type="FunCoup" id="B7FSN5">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSN5"/>
    <dbReference type="PaxDb" id="2850-Phatr43564"/>
    <dbReference type="GeneID" id="7197590"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43564"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSN5"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="434" mass="44650" checksum="36DD59CD74605F7B" modified="2009-02-10" version="1">MKLLVKTLKGEKFEIHAEESQTVADVKGIIEATKSELSAGTLKLIHSGKVLKDEDSIASAGIKENDFLVVMVTKAKKPVAAKPAATPTPVPAATPGPPVAAAASIETPAPTAAATPAAPTRADDVSAEAVANLTSMGFPEAEVKHCLRAAHGNPDIAVEFLTNGIPEGVAEAAAAMNTSAVTSPSASSESSSGSGQPLQALRNHPQFNDLRRLVQSNPQMLQQVLTQIGQQQPQLLQEINANQALFLQIMNEPVESSASVSAAPAVSGSSDAPSLGGLDSGAAAMMEGMGNPAQMAQMIQGMSPEELNQMAAMMGLSPDQLRQTAQMIGQMPPEQLSQFMMQAMGGGEGPESMGGSQVLRLTEEEMAAVDRLAEMGFDRSEAAQAFLACDKNEALAANLLMDSMGDGGGAFGFDGSGNGNGDNGDGGDGDDMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTG4</accession>
    <name>B7FTG4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178148.1">
        <property type="nucleotide sequence ID" value="XM_002178112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTG4"/>
    <dbReference type="PaxDb" id="2850-Phatr43782"/>
    <dbReference type="GeneID" id="7197288"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43782"/>
    <dbReference type="eggNOG" id="ENOG502RWNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290790_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTG4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="24130" checksum="DCE45088851B38B2" modified="2009-02-10" version="1">MFIERNSFFLRVGVKFHAAPTAELAAQRSGEILSLSEKDRDEGRPAGAAIAVVQIAKQVAAFLLRHMAFDAQPDVALERTMKDVHDRLPSTIPAILWSAAARKLHLIDSAGFDNRLTSLLRLTTGNSDREHTSEVMRYRRTLVVKQKALRSRLPFPCVDCFDPELNVDPIIRLSSSANECLIDELNQLDNILARSERWVFFQKARLQVNPSPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTK0</accession>
    <name>B7FTK0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178429.1">
        <property type="nucleotide sequence ID" value="XM_002178393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTK0"/>
    <dbReference type="PaxDb" id="2850-Phatr44277"/>
    <dbReference type="GeneID" id="7197951"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44277"/>
    <dbReference type="HOGENOM" id="CLU_1126372_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTK0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="27016" checksum="3C4054D5C0EDFFDE" modified="2009-02-10" version="1">MTTSQENGTDVGLVSGKPNDKAAARNDCRRQRARGMLAFLHPKVWYFPYDAVKVHKEMAPNTTVRQRKRHRREQQQQYIPESTAIRIPLAELIDTTTQLVVLCFLDDSQSFSIRIRNRLVELAANYPSEILVVGVGSVDCSDDRELASSGTHWNATFWNHTGLVLTSRTAALRAVLPTVQSRTPALVLLQAPSGQRVAGASAYEELALEGNASVHETALRWLAGESALSKTQQVAAAAGLVPACALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTM1</accession>
    <name>B7FTM1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178439.1">
        <property type="nucleotide sequence ID" value="XM_002178403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTM1"/>
    <dbReference type="PaxDb" id="2850-Phatr44299"/>
    <dbReference type="GeneID" id="7198009"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44299"/>
    <dbReference type="eggNOG" id="ENOG502TN4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718596_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTM1"/>
    <dbReference type="OrthoDB" id="47884at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855428" evidence="2">
        <location>
            <begin position="26"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="385" mass="42547" checksum="0A215FAC54F0A63F" modified="2009-02-10" version="1">MNSRTTSSLIAAAIVWSVVTGLGLAQNICSPQVCSAFVGRTGFRCVKRSCGVRRRCVSPGLQTRPTVVKATTQEDDDENLYVTNNGSGSSNNSGSVSLRRRAQFSFVTVSPNGFWVILKIGDNRFLPMQITDTTMDQASATTPEALTVLQLLSDVDMAGAILPPDALAQLVVRHCEEKVELQKNEVCKTSLQIVKAVKEELPPNNDSYSSLHQWFRSRMRLPVSTLDEVVVCLTENEDKAILNLQVAVKDFGILSVRPSEDTVQEICYDYRPATSAYFLGLALALRYKSPVVLEAPSDAQAFLTMQQIEERFPMYTTVDRLQQTSSRVTANIEKSFQINQLQAALRIALEKGDAQAAVKIRAQLDIQDSMEDLPTQPESETDKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUC6</accession>
    <name>B7FUC6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178572.1">
        <property type="nucleotide sequence ID" value="XM_002178536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUC6"/>
    <dbReference type="PaxDb" id="2850-Phatr44507"/>
    <dbReference type="GeneID" id="7197726"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44507"/>
    <dbReference type="eggNOG" id="ENOG502SYIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1859172_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUC6"/>
    <dbReference type="OrthoDB" id="204467at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852698" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15090" checksum="25D221221FCA1B86" modified="2009-02-10" version="1">MLVPFQNCCAVLLLWSSLAVKDTAAFAPPRPQRSPSALYVHVPPPPLVVVVPSDLSTVAAGSTVDAVTYGIDNYLQRPSVALSSSSSTTLLSLEERKPPTAEEIAAKKRNFNLFFWGGGFVAPFLATFYYFGFKFWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUN6</accession>
    <name>B7FUN6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="3 7">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HemD</name>
        <name evidence="10" type="ORF">PHATRDRAFT_44610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>hydroxymethylbilane = uroporphyrinogen III + H2O</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3 7"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178352.1">
        <property type="nucleotide sequence ID" value="XM_002178316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUN6"/>
    <dbReference type="STRING" id="556484.B7FUN6"/>
    <dbReference type="PaxDb" id="2850-Phatr44610"/>
    <dbReference type="GeneID" id="7198106"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44610"/>
    <dbReference type="eggNOG" id="ENOG502QST9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_2_1"/>
    <dbReference type="InParanoid" id="B7FUN6"/>
    <dbReference type="OrthoDB" id="443551at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042:SF1">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855343" description="Uroporphyrinogen-III synthase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="296" mass="32171" checksum="9E9C3896AD0992B1" modified="2009-02-10" version="1">MWLVVVLVGIVTSTSNAYEFSLPRIPRRSKSLSPRLAMTSTSSAEDSIAVAVTREDGNNKKLLKALESRLAGRISVLEVPCIAHADGEDYALLAEKLRSERWDYVAVTSPQAAIILNSAWDSVRDDPIPVTAVGKATSEALEEYGIAVSFCPSKAIATTLMLELPATRVTDATRVLYPASAKARTTLENGLRERGFEVVRLNAYDTVSAHWTHIQRTNAEKCQVACFGSPSAVDGWLRNSNNNTTVLAACIGKTSADVCRDRGWPKECIFFPDKPGIEGWINVVEEAVDALVSETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUU1</accession>
    <name>B7FUU1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178378.1">
        <property type="nucleotide sequence ID" value="XM_002178342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUU1"/>
    <dbReference type="PaxDb" id="2850-Phatr44656"/>
    <dbReference type="GeneID" id="7197647"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44656"/>
    <dbReference type="eggNOG" id="ENOG502SCQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368633_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUU1"/>
    <dbReference type="OrthoDB" id="48314at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="598"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="81968" checksum="E38EB152B5E31F27" modified="2009-02-10" version="1">MSVCVDDIDNDDDESSTGEKSIGNRCASPPVHAMLDTPDVVEQTIQTMETKHLCVPAQHGHAFQPIHFAFGLRTCAACRGRLGVVVFGHNEAQGIVKCVTCQVLAHRRCALAPNVLWQNHCVGTIRQLADTSKENETGKTESTSIGNLDTASTVTDTVQPNPLNEAVHERDNGDTKDASKRHLDNPTDWGLTWTDQGPPHHWASSPQNISLAIPTISLQSRTSSSSSSSTTTTSNVANDGEDSATGVESTTTPALHYANHPFASVSRALQENVVAHFRRRGASTDSTTADQADENGIVPKALQVDAVPDSKPVDDHDQHHPLLKLASGTYEAAKASVTLPRRIGVATVAGGIAGGMAGIVLAGPAGALAGYKLGQACGMLGVILEGSVSIGVFVASVATAGYTAQQLQEMNERRVLTMGEESTSLKVLLVRPNIQIDPIWAQICTDAKRDAPKESTQPFHMFSDGFNVRYRRDEDIVKADEDEIPTNDKILLLVSRILNDKSSMPGYVYRALIEQFCIRGEERARVLQESTSVTALSTRSRRDDAHAVIKHVTATLLEVRPGFGHSRAITELTAAAVESLVFGKLYDSVFGEIAFETEEIDTKLLDRVAEFEASEHSINKELVSEQALAALCTLPEAHSAVDKLHYGVKFLELLSSHFSESGNPICADSLLKMACQHILAAKLPQMNAEVAFLEEFARDEQLLKGREGYALVTLQASMHFLNLSQDFYRDIFAQEDTEDNIPLEPSEKGTYKLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUW0</accession>
    <name>B7FUW0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_10674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178665.1">
        <property type="nucleotide sequence ID" value="XM_002178629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUW0"/>
    <dbReference type="SMR" id="B7FUW0"/>
    <dbReference type="FunCoup" id="B7FUW0">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUW0"/>
    <dbReference type="PaxDb" id="2850-Phatr10674"/>
    <dbReference type="GeneID" id="7197912"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10674"/>
    <dbReference type="eggNOG" id="KOG1466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FUW0"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="290" mass="31615" checksum="65A9F91669217268" modified="2009-02-10" version="1" fragment="single">VAAIKTLLGVVQRSRAETMMGLQDDLKQAAQLMMDNFATHRDSGAGRSHIALQSGCAMFLKYVTRTFLELSDFEACRQAVLERGERFQMISLAARDRIAKAAVDFIPPNATVLTHGYSRVVAAILSQASQSRHFSVIVLEGRPDASGPKIAQFYAREAHIPVKIVLDAAMAYIMEQVDIVLVGAEGVMENGGVVNKLGTYTLATCAQAAGKPFYVAAESYKFARIYPLHQADLPLHPMAPLEFAIALDESIQVVNPPVDFTPAKFITLLFTDLGVLTPSAVSDELIRLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUY9</accession>
    <name>B7FUY9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_10852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178403.1">
        <property type="nucleotide sequence ID" value="XM_002178367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUY9"/>
    <dbReference type="STRING" id="556484.B7FUY9"/>
    <dbReference type="PaxDb" id="2850-Phatr10852"/>
    <dbReference type="GeneID" id="7197926"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10852"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041178_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUY9"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="167" mass="19249" checksum="7207BAE4F6D15141" modified="2009-02-10" version="1" fragment="single">MPYVIPGPYPTLPNLSWLELVCQILAILIANDFLLYWGHRIQHESDYLWQFHAEHHRISTPRPLTTANIHPIDGTLQGGLPLILACAWFKPHPLIFYGLIVVRYGENVLNHSGLDTWWTRALKGSWFVPFVRAGVNHHDRHHKMSNHAKGATNYGESLVIWDWLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV48</accession>
    <name>B7FV48_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179077.1">
        <property type="nucleotide sequence ID" value="XM_002179041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV48"/>
    <dbReference type="STRING" id="556484.B7FV48"/>
    <dbReference type="PaxDb" id="2850-Phatr44975"/>
    <dbReference type="GeneID" id="7199652"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44975"/>
    <dbReference type="HOGENOM" id="CLU_621833_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV48"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="5">
        <location>
            <begin position="264"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="441" mass="47536" checksum="C784FCBBECD0A89C" modified="2009-02-10" version="1">MENVRSRGSKAMIHEDSSGDLDALDESSRCENGVFFKPSFTVEPSAFSSSSSSLSTSSIPPFRRSLLSMSSDSRQDPRSVSAGKLRRRVESSPSPEPIVCNGIAIGLDLSTDFGAEGRVLERSPADDDYSPKENSTNALGVSGFLSATHKSWRQHRRSLTRLHAIGMLSLGLVALLGVLAGVAAPQVRTRKLLGGRAPSPRESRRVLRQIESGTTGKASVLTVRLHGHRIDLIQRSLDQHARCNVVAEAQIDWSDRNLPDSLLNHFSNKVSPVQDVPDGAVLFLDESVLLSCAEIERALGEWRQDPTRLVGFSTLQVAYGPSVLVSSRAVVAHNLYVDNFKTHTHFQADVCDHLVLSARVAAISGKSPVVVAAHPRVVAQTMSAPVVSTKTSTDDEVYDSSDELQHSSTDARCVSRLLKAVGLTTLPADPEGAGITYIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV70</accession>
    <name>B7FV70_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178874.1">
        <property type="nucleotide sequence ID" value="XM_002178838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV70"/>
    <dbReference type="ESTHER" id="phatc-b7fv70">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr44989"/>
    <dbReference type="GeneID" id="7199510"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44989"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504804_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV70"/>
    <dbReference type="OMA" id="WWDSSSH"/>
    <dbReference type="OrthoDB" id="41686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="216"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="540" mass="58308" checksum="B53F671F730AC8D2" modified="2009-02-10" version="1">MSGDAKNGKHAKNVTRATRIIKTEAGGECTDNQIEISTELSVGENGLAPMSSIRRLARNINRQLSRRQSSLQEALPDTYPGWAALLATLSAAAVGYEIRLQKRLTGPPLVFGQCQTSPRLSEIYARLTASPSAILRRDIQPSLFVGTRASVASTFAYLLPGPSRLDSHPRFREILTMPADGAKVAIDWELPPSRGNRDRPLSIEESAVRNGPIKVPIVVILHGINNHANFGYIRSLMRVCTDKGWIAAGLNFRGCGGLPLATPRGYNGAYTGDLRAVVQTISGRLAPDAPLLLVGNSLGANLVAKYLGEEGLSNTLPPCVIGGVTLGNPMRMNAGTMDPALSSLLALGAKKTLLENWPSMKHMTNSSFRGAVKGALLGYSLADFDSSLAPLYVRNDPIFPYALRLGFQDGEAYWKDASSYRFLPFVSVPLLQIIAGDDFLVYHPFTSKVNHAITNPNVMVVETKCGGHLGWQESQLDVNAWGVGTSWADVATVDFLQAVMDTRIIAAKKSANGKASVHDGNALYNRMDATDEAVRLRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV79</accession>
    <name>B7FV79_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178878.1">
        <property type="nucleotide sequence ID" value="XM_002178842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV79"/>
    <dbReference type="PaxDb" id="2850-Phatr44997"/>
    <dbReference type="GeneID" id="7199515"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44997"/>
    <dbReference type="eggNOG" id="ENOG502SIHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332747_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV79"/>
    <dbReference type="OrthoDB" id="193473at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="879" mass="97063" checksum="FC509F15DCC41B01" modified="2009-02-10" version="1">MEETESFLDASVKSSPALASFSSSRSGAAPKAQSSHPLDRRWIFYVAAFGTLLVLYFGNWSPAQDDTATPLLPNGGAEAVPAPAPGAPSSSQTDTVSPIKPQGPLLYSKMATIVPDPEHVPVNATAQAALADAWGRWHFWDGDEDSRPTADYCAEYENRDIPGDEFPDEAWQVDAVFVNHLLNDAEQLLQRAQEAIFTEYGHGKPLPPEGLAARLKMFAWEKLDLLDPNETPPEGYGGRARNRGSNGGWTTESGFDGLVRRLLHAMHTNDQFVVVLGGHSAAAGHGNHFHQSYAMQFHRVVAPVLARLGVKLVTRNLAMGGLGTVQQSLGSQSLYGSDIDLLWWDSGMTEPQSSLTDLFVRHALMSPGKVPVVWGGGFDILQPIFQQTGADVGEFGTGMLGIPVVTSEEQAMTIPYPARYMLCDKDVTPLCQEDRFCGMCWVDRDDVDKSQFTEIHEIPGARVKWHPGWRSHQWQGRVLAYAVLEALQVAIQRWSDGTMGGPPLEDALWHVTAHYNSIRDKVRTVQGGECRALDDLVSPRVCSTPMKGATLFTPRANPEETSLTKLIKPAPNGYVPTNQRKVLYDGPDRHNECYDVKEGGIDILAIISGRRRLEEQVTPSGPTFSDWRSTHESGTDTEKPLVAIISPQRNASRSERRAASDAIVPGKGWQVVSEMPGQCDGEYHSVCGRHVDISCPMLGHHDGRGVLVGNEYSGWIVLNLPKVTEGLIIIKLFTWGGEGMNTITQGWTTVNNEGGRRLRGSSNFLQKEENLSRWNESSTTIESEKERYGGELDERRLDPKSIENYPNAFEFDYAINGKITTLNRDQFRDRVKDLARVVEVMTLLDDPDFVSGPTDVEIAFRMRNCGHLCTVSLTHVYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVC4</accession>
    <name>B7FVC4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179113.1">
        <property type="nucleotide sequence ID" value="XM_002179077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVC4"/>
    <dbReference type="PaxDb" id="2850-Phatr45029"/>
    <dbReference type="GeneID" id="7199692"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45029"/>
    <dbReference type="eggNOG" id="ENOG502RRBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405727_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVC4"/>
    <dbReference type="OrthoDB" id="49585at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030657">
        <property type="entry name" value="TERF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46833:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46833">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2 TERF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="619"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="678" mass="77545" checksum="F6C1BF314C602240" modified="2009-02-10" version="1">MSFLLSLFRSPEEKETPLASRDDTNNNNNDNSDNESDNGVLQPPVVPHSPSLTTAHASSKSFASIPPMPSRQTSGMNRDRSFSKVFNQLPPHLPTLQEMQMDLMEYLCHLILLQTNVAKALLYKTQLTQVLESHQIHKYGRFYSRLNLTALGCDLLCLPESETPETWTTPQDWAHMREQLVLTKSLLLRRDANVWVPTAMEESESPTPADAALETTPSLPQPNDAIDHQLETHEMFQDTYQQVYEFVHVQEIIARLRLSLQEVIVTPDENDDRRIPRAREAVELYQQQLGALFHGPEHIPKDLTHFLLRDLYRNHHDWIRTVPTHLEELILHPRSVFSLAKLQQKVRSLLIKWSESILEIPTLVKIGYGGVMAPVVGDDGDDDVSAWGDDDEHAPTAQELLTQPPPSMDEAHEPLPASTRPLNQRSSVTIEDAETLKQLVLAPPPHRTRTRVTTTTPSQRPTPSKDLRRVARQNVRREQELLTQPEMDRGESDHDRSDEEEKDDDVEHAQSEGEKENDPDERKILTTLSREQEERLFEDSSTDEEEEPERSTEVATRDNRQIEVLSSSQKRKRHPRVSTSPATPVKGRSTENKLHKLSRWEDSDVEEFDALFVTEKQPLSGHKKRPFSSLETASIRHGVRQFGMHSWAQIRDTYPALSSRSGQQIRDKFRTMTKHGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVF7</accession>
    <name>B7FVF7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_1473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178698.1">
        <property type="nucleotide sequence ID" value="XM_002178662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVF7"/>
    <dbReference type="PaxDb" id="2850-Phatr1473"/>
    <dbReference type="GeneID" id="7199711"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1473"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FVF7"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="137"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="312"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC49396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="476" mass="54518" checksum="30930D42E5361503" modified="2009-02-10" version="1" fragment="single">LTPQYFHWVKVCFYLSDEEIINRIGYDALVFLRFHRLALRCIVKMSVFSFIVLLPLNFTGGGHANAQDLKEYVGSLFFTDFLRFTMANVQSGSPRLWVHCFAAYLLTGIVVRELLIEYEHFALIRHRYLLSSEPHLRTVLVTNIPRHLRSASKITSYFRHVYPDAVKSVFLCQNLIQLEKMVQARTTLLSNIETELLVLCRTEKKKLYEQSYLRRSILTFRLRYCSAEDGTQERLADYYSQLETLNEEIEKEQRRRLTDKAFVVMRTYTAATIAIQSMHSSKPGAMHVVTAPEPRDILWYNIYMSKGAQRTRSYMGEFLVLLLISFYAIPVALISLLVSENALISNSPRLAQLDQASTFFSAAITLVQPLCIVGLQQLLPPLFMVIGRAEGRIAFSDAQMQAFSRYFLFQVLNVFLVTTIAGSIFDTVAIIIENPESAFEMLGNSLPRMSSFFITFVTVKTFLALGLELVRCVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVI1</accession>
    <name>B7FVI1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178709.1">
        <property type="nucleotide sequence ID" value="XM_002178673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVI1"/>
    <dbReference type="STRING" id="556484.B7FVI1"/>
    <dbReference type="PaxDb" id="2850-Phatr44750"/>
    <dbReference type="GeneID" id="7199724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44750"/>
    <dbReference type="eggNOG" id="ENOG502SQ1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730512_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVI1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001611">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="379" mass="41642" checksum="3C401DD837495F4D" modified="2009-02-10" version="1">MNAYSTLQVSSLQTWNVPQLNQSDGCGPTTIRYPNPVPSPHSSTAVASVTIPASDAAPYAISPETSPRDLTLRHNEIPNLDDIPDIAKEALRITKESLGSECQLLHQDTTNTRKLPTIATGSRLNKFVRRLHDMLKQEQASGVVEWRKGLLVLHSTNSFAKQILPQYFNTRNFKTFRRQLNYYGFVHVRSFTTAGSATTALWVNQHLAENGSDDISSVLRLKRVEPCDAAKTAESRRERKELAIHTVEEDLGVSARTLQVEQIRSMALRGSREQVQAEILRGLERTPAIIVNAATTESALKVVKQVTKSVKPPVPREIHCTSMAVGGDLQQSRDSSSNQGSTESISSYGSGVNHDDPTQISLDEDSGAANLLLFLSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVP9</accession>
    <name>B7FVP9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178744.1">
        <property type="nucleotide sequence ID" value="XM_002178708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVP9"/>
    <dbReference type="STRING" id="556484.B7FVP9"/>
    <dbReference type="PaxDb" id="2850-Phatr44804"/>
    <dbReference type="GeneID" id="7199757"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44804"/>
    <dbReference type="eggNOG" id="ENOG502QS7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872842_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVP9"/>
    <dbReference type="OMA" id="TTWCCRI"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="320" mass="35509" checksum="369B48CB1A5AE186" modified="2009-02-10" version="1">MVAAKSRQDDELTELLTKLYTIQEEIGAKPKSSEDEKRAKAENVAVMGQGKKAQAKGSKFLDLKSTILDRLKTIHGLLKATKEKEQAGFGGDNAKDIIKMQANVREHLRQATDEWKEMDEIYKKEARKKKSKFTPEELEVQSELVRRLYAEIDKVKEVQMRGYTRSRQPDAAVSLNTKALYTDSASSSRKGGSKSASWAGTGGGGGVAMTDNQRQQMLQLEERDADFDKQLDEIGEGILDLAEIAALQGEEVKRQSVMLDGVNNKMDKVGERMTSVNSKMKETLDEVGRSADKLCVDIMCVVLMVGFAAVIYNMVSNDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVS4</accession>
    <name>B7FVS4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4954 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178982.1">
        <property type="nucleotide sequence ID" value="XM_002178946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVS4"/>
    <dbReference type="STRING" id="556484.B7FVS4"/>
    <dbReference type="PaxDb" id="2850-Phatr44825"/>
    <dbReference type="GeneID" id="7199547"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44825"/>
    <dbReference type="eggNOG" id="ENOG502R9XZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030321_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVS4"/>
    <dbReference type="OMA" id="GMNQITP"/>
    <dbReference type="OrthoDB" id="118763at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032533">
        <property type="entry name" value="DUF4954"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16314">
        <property type="entry name" value="DUF4954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4954" evidence="1">
        <location>
            <begin position="45"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="686" mass="75138" checksum="84D454AC2BD7636A" modified="2009-02-10" version="1">MNALNEFEACRAEREAQIACIHRLRECAAQSLRRVVEVSDRQVIRSLYREEVDALQHHCGCHCSDWTQTRLVLSKDERSVDQSVRLRREVSKTAFDGMVVLILDRPSLRPTTSDYAKLPLGIHNNALVSNSILSLGARVYGNGLVCDTFVGSGAILLRCGSISCKTSRNYQDLTVTVGPESGGGRKIRLLCEATMIEVGHQLKHPSADLRDTVSDSPDKIGFRFNVVSSECIVRETPTIDGIYLYPAARLDAATNVSNAVLFSGASICNASAVSDCILQWDCTVTDHSIVTSTFLMEQVVAGPKAIVASSVMGPDVHVSAGEVHASVLGPNTNAHHQSLLISVLWPLGRGNVGYGANVGSNHTGRIPDQETVAGEGVFWGLSTVITFPVDLSFAPYSIIAAGTTLGPQRVCMPFSLIASNPYGGPNNIIPGWVLKSSPYAIMRSEKKFSIRRKAKRHSYYTGWKIIRPELIDLCLSARSMLRYGLDAQSSNQSEKSISGIGDSKLNEKSRLSGIKAYTECIHRFILSGLVSFLFDATSDGAPVVETVVSMAGEVMAGSRKSSLDKSIGDVPRWGEFPWETDVSSLWKYQRALLLNEFPFSTTVPESWIRDRVEAFLLLEQQHATAVFQCKNRDDVRGLQIIPGYETSHDAAEKDSIVADVREDLVLTEANVASLLERLDEQQRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWG1</accession>
    <name>B7FWG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179151.1">
        <property type="nucleotide sequence ID" value="XM_002179115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWG1"/>
    <dbReference type="STRING" id="556484.B7FWG1"/>
    <dbReference type="PaxDb" id="2850-Phatr45096"/>
    <dbReference type="GeneID" id="7200176"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45096"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361510_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWG1"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="408"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="765" mass="85045" checksum="6658479DD07C3E97" modified="2009-02-10" version="1">MYKLASGARTLTTQQLLLLQIPTLFSGPTVTHGPLAIAPSSTTTTSRRMTSKATATYDGRIVARILPPNACNAAFDLHHDIRGPRMDPTLLKAGAGYLAHRASVPITQSTDAAVGASLLGTEYSSEQNWTTLDVYVYPQSARGGMDTTGSSGESSSVVAATATHIHMQRHSSETLEKTLARMGLSLFKKLSESTKHCHKRTRAYKARNTQLSCNATIWKVDPESGVPTTPWDCQSLTNYNAWSEARYTPLAIQISLVDVELSEMDGSSSVPQTLTFAVESCPPTVTTVRTFSDWESYLYPSVPIVVQTETMYKSDQCMVDWYVNGQLLQSNSHSYTPTEADLGKSVAILVTPIRKGQHDGAGCQEAYQFSTLVQPLPENLILSLRPKWIAPRCDRSSGEASDAPLRIMTYNVLADQNAFDFGVSGKVAHSYAEYLTPQVLKRERRLPLILHEILAHQADVVCLQEVDEYVYETLFKSALRYAGYDGFFTSKENEGSREGCATFWLTTRFDPVPESNKKSHLIRDMFPFESKTDDQEWTALNDIAGLLGKRRDLRYIVAAKLGHILHLVPLQVKGDTKTIWVANTHLFYHPDASHIRLMQMYLICRELSESLKTKDGGIVLCGDMNSSLTNSPGKLLIDRIVPKNFRNLRTDLNGFRWSRQWRQPDSPNAFDDDFPSLSLPDSFPILRSALSETPAFTHFIGGLERGFRGTLDHILVSPDLIPLKSGPMPSMRDVTRDTAMPSERIPSDHVSLICEVDMTKMSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWZ6</accession>
    <name>B7FWZ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_11608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179249.1">
        <property type="nucleotide sequence ID" value="XM_002179213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWZ6"/>
    <dbReference type="STRING" id="556484.B7FWZ6"/>
    <dbReference type="PaxDb" id="2850-Phatr11608"/>
    <dbReference type="GeneID" id="7200118"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11608"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328040_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWZ6"/>
    <dbReference type="OrthoDB" id="36727at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="76" mass="8519" checksum="2769DD453C8384E5" modified="2009-02-10" version="1" fragment="single">RVLYLDNVVQSRLLGETAYHESLVHPAMFSHQNPRRVAIIGGGEGAALREVLKHRTVEMVTMLEIDEAMVNASRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX54</accession>
    <name>B7FX54_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179280.1">
        <property type="nucleotide sequence ID" value="XM_002179244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX54"/>
    <dbReference type="PaxDb" id="2850-Phatr34949"/>
    <dbReference type="GeneID" id="7199940"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34949"/>
    <dbReference type="eggNOG" id="ENOG502QS8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FX54"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909:SF2">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="318" mass="35326" checksum="BB56A8A26C67507C" modified="2009-02-10" version="1">MWTSEGQPLAVVSKSPSSKRAIPNNVKLVVLPGFGNNSNDYFLPEAPQGSLVRSLQNRGWRDDQIRVLPMERLDWLQVFVNGLFDLRFWTSNMAATCPSFRWYLKCVAGEIAEICEESSDTKVVLVCHSAGGWLARAALGYFSQAQADEQDVPRIELERVLGMVTLGAPHIPPPPEVMDMTRGALRITNEDFPGAYHIDDGLFYITVVGNAIAGIKDQRRSPFERTTPTGLAFNSYEAVCGAGTSMGDGLIPRMSAHLDDAIQINLDGVFHSINAPDKWYGSDSLLDRWHDTMLEQIYSSRNMSVRTPNRDFGNVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX68</accession>
    <name>B7FX68_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">H4-1b</name>
        <name evidence="14" type="synonym">H4-1a</name>
        <name evidence="13" type="ORF">PHATRDRAFT_26896</name>
        <name evidence="14" type="ORF">PHATRDRAFT_34971</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179286.1">
        <property type="nucleotide sequence ID" value="XM_002179250.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179505.1">
        <property type="nucleotide sequence ID" value="XM_002179469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX68"/>
    <dbReference type="SMR" id="B7FX68"/>
    <dbReference type="FunCoup" id="B7FX68">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FX68"/>
    <dbReference type="PaxDb" id="2850-Phatr26896"/>
    <dbReference type="GeneID" id="7199948"/>
    <dbReference type="GeneID" id="7200159"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26896"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34971"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="B7FX68"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="36069at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC49328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="103" mass="11383" checksum="84E4A9C498B9758F" modified="2009-02-10" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDSVTYTEHARRKTVTAMDVVYALKRQGKTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXG9</accession>
    <name>B7FXG9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179333.1">
        <property type="nucleotide sequence ID" value="XM_002179297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXG9"/>
    <dbReference type="PaxDb" id="2850-Phatr45376"/>
    <dbReference type="GeneID" id="7200001"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45376"/>
    <dbReference type="eggNOG" id="ENOG502RZFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_557224_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXG9"/>
    <dbReference type="OMA" id="YAEMNDH"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855144" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54548" checksum="202DBAA79A074197" modified="2009-02-10" version="1">MGQQPGGILLLLVWLSVSVRGSLAFRPPTPVRPFPTRCSVASSDNNDSAERSTTAATSTARQHNDIDDDEVPSDAMELGLDAKQLALLEEEQQKFLATCKVLCEQRNFPLEKVKNARDLSSVQNSPVQRNRILRMGRVSDASQDDIQLLFHQLNITTLIDTRSPTELKDDTTLLREQVFGNFTNMMWQEQGRGRDGCVKELEPGQQPVRPRSLKRFWEKDQGVAAATTAISETEISPSVSTEIIAQEHLEAELEISAEEDVCGLDCDEDDPETMQESTVLRTYQGNRKERHFVSLMNEFKYVKGTVGKLRKRDLAKAALRSPSAIFSKKARTAVKKPFLDEINDGGLPMLNELLLRFGAPGIKYVLELCADRTRHPVAFYCTAGKDRTGMLTAIILALCGTKAEDIVEDYSLSANVYAEMNDHQAMVGALSQRSLDPKTFLGAPPQVMRDTLLAIEENYGSVEGYCTWIGFGPEKQQKLIQACTQPDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXL7</accession>
    <name>B7FXL7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyl transferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_12031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179790.1">
        <property type="nucleotide sequence ID" value="XM_002179754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXL7"/>
    <dbReference type="STRING" id="556484.B7FXL7"/>
    <dbReference type="PaxDb" id="2850-Phatr12031"/>
    <dbReference type="GeneID" id="7200534"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12031"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_1"/>
    <dbReference type="InParanoid" id="B7FXL7"/>
    <dbReference type="OMA" id="QILNIHH"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13740">
        <property type="entry name" value="ACT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="297" mass="33631" checksum="4F242694827802B4" modified="2009-02-10" version="1">MSFSNAKQTKTPIARPQLGTLRIHGPDQNGIVAAFSQLLYGHGCGIVDSEQHTDHSANLFFQRIHFDYSKMLTDRISLGNGVDEVCKRFDMKSALNWGDVRQQVAIMVSKYDHCLWELLLRHRAGELDCDICMILSNHPDLQTVADAFQVPFHVFKVTKDTKEAVEKEELELLATHKVDLVVLARYMQIITDNFCESVSVINIHHSFLPAFIGGKPYHRAHERGVKLIGATAHYATADLDEGPIIEQDITRISHRDEVDDLLRKGRLLEKNVLVHAVKAHIEDRIIVYNNKCVVFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXP6</accession>
    <name>B7FXP6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179804.1">
        <property type="nucleotide sequence ID" value="XM_002179768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXP6"/>
    <dbReference type="PaxDb" id="2850-Phatr35145"/>
    <dbReference type="GeneID" id="7200549"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35145"/>
    <dbReference type="HOGENOM" id="CLU_820068_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXP6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="339" mass="37974" checksum="2E271FB7583CBF3A" modified="2009-02-10" version="1">MSNSFSSDASLSSSSFLVTESMVRGDDCSIASSVPPIVTPVRATMDPVPTAVHVETAKVSIKRRFDSMNYCIEEAIKASKHQYDAGPSGLYLEVARGSTKRRFDFATENAKKKEFYMQDRQPYYEQAELQKIVKPIPVYATKEGQAHLVALIEAGDMKPRPSRATPASLFHQRVVEWETTQPFQTEVIHDEQHENASLLNGSIHSIELSDDEDDVDSLYDPLEIFDDAAPDLPLLEVDGHFIHTMAGQMDFNHPLLFAGNQAAASLIRYNGNCNNEDVSLPILAIPKVWDAKDLLYSVRSNRGSHVHESSKFTDKFQYCQSGQRLYNRRSRGLPPLYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXR9</accession>
    <name>B7FXR9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_41129</name>
        <name evidence="2" type="ORF">PHATRDRAFT_45457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179605.1">
        <property type="nucleotide sequence ID" value="XM_002179569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185194.1">
        <property type="nucleotide sequence ID" value="XM_002185158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXR9"/>
    <dbReference type="PaxDb" id="2850-Phatr41129"/>
    <dbReference type="GeneID" id="7199088"/>
    <dbReference type="GeneID" id="7200561"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41129"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45457"/>
    <dbReference type="HOGENOM" id="CLU_1071419_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXR9"/>
    <dbReference type="OrthoDB" id="45334at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24174" checksum="54D67AD475C12827" modified="2009-02-10" version="1">MNWRAASSASLRNAKQELVRLLFGARYTRVGRYEHRRLDYAVYCYTDLRTAFLQRAQVLHPDKLQCSHKHARGREASKKEFVALMEAWNRYDEIAKTVKGVGSSETSANFTMFGVGCSFSDNDDERLLREKIMDQACRGWFSSGPLGVGGCETDQTARKDLRVEHTISFITDDDFVEEVKENAFRENSVKPSSIRSMKHLVGKFYPGAINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYS6</accession>
    <name>B7FYS6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formidase</fullName>
            <ecNumber evidence="1">3.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_54476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.49" evidence="1"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180029.1">
        <property type="nucleotide sequence ID" value="XM_002179993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYS6"/>
    <dbReference type="STRING" id="556484.B7FYS6"/>
    <dbReference type="PaxDb" id="2850-Phatr54476"/>
    <dbReference type="GeneID" id="7200825"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54476"/>
    <dbReference type="eggNOG" id="ENOG502QRMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="InParanoid" id="B7FYS6"/>
    <dbReference type="OMA" id="ATWNKRE"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004328">
        <property type="term" value="F:formamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="451" mass="49265" checksum="C2B07E54F6E693B5" modified="2009-02-10" version="1">MVKTLISVDPKRLPWEQETPLHNRWHPDIPPVASVEEGEIFRVECVDWTGGQIKNDDSSDDVKNVDLSQVHYLSGPIAIPTAEPGDLLKVELLNLGCLDGDEWGFTGTFAKENGGGFLTEHYPRASKAVWDIEGIYCSSRHIPGVRFAGLIHPGLIGTAPSAELLKMWNVRESALCEEEGTPNEKTLCRCLYTRPLACLPDPKGAMLGQLGHFKAKQGNDETWDKVAAEAARTVPGRENGGNCDIKNLSRGCSVYFPVFVPGANLSMGDMHFSQGDGEVSFCGAIEMSGFLDIKCSVIKGGMEMLPVVGPSPLSVNPIFEIGPLEPRYSEWLVFEGVSVDERGMQHYLDATIAYKRAVLNCIKYLAKFGYTEEQVYLMLSCIPCEGRISGIVDVPNACATLAIPLAIFDRDVRPPKTMAMLEQLANGIKVLNKDVCLSTEGGAEAKDSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ55</accession>
    <name>B7FZ55_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_45917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180290.1">
        <property type="nucleotide sequence ID" value="XM_002180254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ55"/>
    <dbReference type="STRING" id="556484.B7FZ55"/>
    <dbReference type="PaxDb" id="2850-Phatr45917"/>
    <dbReference type="GeneID" id="7201132"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45917"/>
    <dbReference type="eggNOG" id="ENOG502QSQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_7_2_1"/>
    <dbReference type="InParanoid" id="B7FZ55"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57126" checksum="7C162C3E31EDF144" modified="2009-02-10" version="1">MWSFRSQNELSHTNRKRPREHRRWIAGMWIILSSLASSSMAFAPFDSPYSKASRRMSTWQAQRILVQETYHEDNYGEGPKSKWFQWFIGGKSRGTNKIIMREAEALGGLPRSNRYASRDWFHSAITLPNSAILRDIRNPVIAITSWASFLSILHRKLVKVNPLAAEHMYFPTAPHSLMMSALGLLLVFRTNSAYQRFTEGRTIWEQIINSSRDLFRLMMLYEKEIGVEKRRRVQTLCAAFPYLLRHRIRPDLVMKTVDDEAYKREPENTILLYQDSGPTDDDAEAAAVANAEEDIGRSRRKTRPLFWVDKRTLPWRLLPPGALEKCARAQNRPLWVCDRMAMELRAVPDQVGFTNRERLALISHVDKLSRCIGGSERIHQTVVPLNYARHTLRALTVWLFSLPFVVVKDLKLLTGPVLFLVSWMLFGVFEIGSAIEDPFQGTLRLSILCDTIRRDVVGDEYVRSTAFFLEEEDAATQGPNGASANKILDSVSSPGEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZE1</accession>
    <name>B7FZE1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precursor of dehydrogenase pyruvate dehydrogenase E1, alpha and beta subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PDH1</name>
        <name evidence="6" type="ORF">PHATRDRAFT_20360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180334.1">
        <property type="nucleotide sequence ID" value="XM_002180298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZE1"/>
    <dbReference type="STRING" id="556484.B7FZE1"/>
    <dbReference type="PaxDb" id="2850-Phatr12375"/>
    <dbReference type="GeneID" id="7201049"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20360"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_1"/>
    <dbReference type="InParanoid" id="B7FZE1"/>
    <dbReference type="OMA" id="PIALYPM"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855215" evidence="4">
        <location>
            <begin position="18"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="483"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="814" mass="87797" checksum="726676D9598A272A" modified="2009-02-10" version="1">MKFSTATLALCVATASAFVPVALRPQSNGVTTYSRTGHALPVSRMSTTVEDTTTTEEASFAPMRPPVDLPWHKITKQLQDAFGYTDTEIEAYNSLDGDKEALLKLYKAMMLARGFENACNQQYMQGKIRGFMHLDNGQESIPGLVDYAVKTQDKKFSYYREHTHALASGCDPGAIMAELMMKDTGSCRGAGGSMHIFDKEKYFQGGWALVSEQLPYAAGAAKSILLDRALGLSDDEKIVKGNVAPPADDDRISVVFIGEGGAQNGRMAELLNAASKDNLPLLIIVIDNGRAINTFTPDIARNSNVYQQGLHYGVPGLLVDGLNAVDVAKGGKAVVDYIRAGKGPAILQVHTYRFNGHSPADPEHERGRKEEKAWARNAQDPIKAFEDAYTANGVFTEDDLKAAKKEILAQVKASVEFADKSPMPPVELAKELEYPDKPSTDYNVRSGPAWADEVNQRTISSSQMETIQAHIAALQQKAKDGEISIGDAINLAIHEEMLRDPTTTIHAEDLQAGSSYDIPKLTQQTYGQIRAADEIIDEGHFIGKALGEALNGYRPIVELMNTNFGIYGMAELSSAGNTFATTGGQFDMPMTIIGAGGTAPDQALGAEHSQPFHAYVMGIPGLKIGTAASPDAAYGLTKSMIRDNGPCFLFAPVKMMKESKGKVDIGKCMPLNKAALLHEASEATVKAGKAVTVLTYLHGVKEATASIDAIREEGFDIDLIELRSLKPLDMETITTSLARTNKMAILDESTKSGGVGATISAQVSEELFDLLDAPVKRLCMDDAPVPYASSMEKAVVKRGSDLIEGVFNLCTKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZP7</accession>
    <name>B7FZP7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180184.1">
        <property type="nucleotide sequence ID" value="XM_002180148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZP7"/>
    <dbReference type="STRING" id="556484.B7FZP7"/>
    <dbReference type="PaxDb" id="2850-Phatr45755"/>
    <dbReference type="GeneID" id="7200780"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45755"/>
    <dbReference type="eggNOG" id="ENOG502QRUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZP7"/>
    <dbReference type="OMA" id="HIRESIW"/>
    <dbReference type="OrthoDB" id="39656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="50"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="486" mass="55715" checksum="A258B2F1B03D47E0" modified="2009-02-10" version="1">MNMVSLDISKRSIGLDSVNVSFLRDEGTQAGKKPFPLVITPRWESSLSFLTTWMEANRAWLDERLLQYGAVLIRGFEIDSGADMQKAMRSFQPKLNNTYRGTSPRNLIPGTEYIFSAAEVPVNYPIAQHLEMSFLPAPPKQLFFGCLQPSQSTGGETALADFRKVYQDLPCDLRQKLLEKGVRYTRTHYKQGARFTYDVASMLSWSELFGTSDKATVERMCAAEGTPVQWTGDDTFVSITQASPYQLHPVTKEPVWFNHIQVFHWTTFTAELWFSWKRTRDWRLLIHCFFVTCFCLIKYGMLGHRMSLHSTFGDGEEISVAEMNKIRHAIHRNMVFSRWEKGDVMLIDNFSTSHGRQPTYDKGRKIVVAWADPMVKTNEFVTNTTAVAIQNEARIVVNESEFVHMENPQERTPPSTLTKEESDVLQEQLSTKNSILQNYGGMNPQDEIFESTILVMKRIVAEAERKSHKKSFSQPSLMHLSQVWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZS3</accession>
    <name>B7FZS3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180199.1">
        <property type="nucleotide sequence ID" value="XM_002180163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZS3"/>
    <dbReference type="PaxDb" id="2850-Phatr35562"/>
    <dbReference type="GeneID" id="7200914"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35562"/>
    <dbReference type="eggNOG" id="ENOG502R9NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853821_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZS3"/>
    <dbReference type="OrthoDB" id="45880at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="29360" checksum="89885E87258B1CC5" modified="2009-02-10" version="1">MVATSQTGTGLLTNILRHTIFGIVTVYLVFAVYEKTSTRSSVVEATAFVSHTRPASVAMNTTNPRLHRVLCFGDSLTAGTSGRQFFPYATYLESKLRSMGRRVQVQHLGMPGWTAPQMLEHLDSNRTGLRRAIRAAQNPGFSLVLLLAGTNDMGRGYGQAETVENILQLHQVNYDSGVPRTVAIAIPPSGYQSVNELARALAGRINQDLRAFCDTEDRATFVPFPFDFERGGANWFQDTLHLSETGNKGLGESLAPIVEKILQEIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G031</accession>
    <name>B7G031_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_5702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180405.1">
        <property type="nucleotide sequence ID" value="XM_002180369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G031"/>
    <dbReference type="FunCoup" id="B7G031">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G031"/>
    <dbReference type="PaxDb" id="2850-Phatr5702"/>
    <dbReference type="GeneID" id="7201443"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5702"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_3_0_1"/>
    <dbReference type="InParanoid" id="B7G031"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="227" mass="25257" checksum="92E6B5AD80CC6026" modified="2009-02-10" version="1" fragment="single">MKFAALVSGGKDSLYSILECQRQGHELVACVHLGRPDDETEESFMYQTAASEVIKTLVEECLGVPLILHVRTGLSVNTALVYEATDHDEVEDLCLALQTTLARFPNIQGVSSGAILSTYQRTRVESVCSRLGLTSLSYLWRRAPQRELLARMIDDGIDAVLVKTAAPPGLMPRKHLGKTLAELQSHFHTLHNRFQFHICGEGGEYETLVLDCPFYKKRLVLDATEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0N9</accession>
    <name>B7G0N9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_54547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180513.1">
        <property type="nucleotide sequence ID" value="XM_002180477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0N9"/>
    <dbReference type="PaxDb" id="2850-Phatr54547"/>
    <dbReference type="GeneID" id="7201478"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54547"/>
    <dbReference type="HOGENOM" id="CLU_290622_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0N9"/>
    <dbReference type="OrthoDB" id="44112at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="900" mass="100509" checksum="90213B100C908B5F" modified="2009-02-10" version="1">MIGFLLPNSTDQINPTYGVVNESTLIRFMSLFRAFLAAICSPSHPIVLFLDDLQWADDASRKLLSSFFMDLDLENFLFIGIVRDGEETTFDPPADTLIPCHQLVCGSLIESNVNKIVAVATGLKEEETKQLGWIVFRRTYGNPFFVKQFLESLHREELISYNAKDERFDWDVDIIAKRMSPSSNVVDLLVDEISSLPRDSQLVLVIASTLGYTFDASVLETILESVDLMSLFPRKLLLDEENAAADPVEAPLLQSHDAFCNVNLQKSLRKASKAGLIQQIYPGKYKFTHDRVQQSATRLLPGGRRGERIKSNLGLLVLELSRSNKSEDWMLFTATNLLLENSIDIDNDKVAKLCLEAAKKASLQAAFKSSATYADSGLKKLGSSGWKSNYELCLDLCSLSAEMHYSNGNLKSTKKRVKIIEKKASKAEDRFRAYNVLIDMLFSEDDFSGCIEEGQRGMEYLGVKTPKNPGLLNVASNLLKCKRLLAGRKASDLSSLPTMDNATVEEVLRLMSTTAMASWHNGDNNHCVVLCLIMFQTTLKHGISVHAPYALVAYAVCLSHLGEMKEAVEYGTAALQLLKLPGMEPAVAKTLVVVHSFLWHLKFPMRESSAELTKAYEVGVKAADSLQSCMALRVAGALGIFVGAKSLPEHESVVQKFCVTLREYKQSGVLKMLLPWAQLIENLRGNAELSTVLRGTFADETAIVEQFNSSSANEVNHRHAALATHYARMVLLYLCGEHQLAELDRKKYSKVEGEMSTYVQKLFHFVFAALNCFALARESSKKAHISKAKKYMSLAKPYVKEGSTSVLALMALLEAELLAAHKKYSPANDQYKRAMKMLKREDFQLLHGIAMERAALCLFDSGKKKDGEVYLKRSWRKFEEYGAKVKLEQMEKLHGSMVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Q6</accession>
    <name>B7G0Q6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_12737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180715.1">
        <property type="nucleotide sequence ID" value="XM_002180679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Q6"/>
    <dbReference type="SMR" id="B7G0Q6"/>
    <dbReference type="STRING" id="556484.B7G0Q6"/>
    <dbReference type="PaxDb" id="2850-Phatr12737"/>
    <dbReference type="GeneID" id="7201488"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12737"/>
    <dbReference type="eggNOG" id="KOG3070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089169_3_1_1"/>
    <dbReference type="InParanoid" id="B7G0Q6"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF20">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CSD" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="71" mass="8025" checksum="B12340726B7482BD" modified="2009-02-10" version="1" fragment="single">MRFFATLNGTVKWFDVKKGFGFIVPDDGSEDVFVHQTSVHSEGFRSLAEGEPVEFSIKEDDRGRKSAERVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G136</accession>
    <name>B7G136_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6816 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180968.1">
        <property type="nucleotide sequence ID" value="XM_002180932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G136"/>
    <dbReference type="PaxDb" id="2850-Phatr46403"/>
    <dbReference type="GeneID" id="7201654"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46403"/>
    <dbReference type="eggNOG" id="ENOG502S9WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_910488_0_0_1"/>
    <dbReference type="InParanoid" id="B7G136"/>
    <dbReference type="OrthoDB" id="195555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049213">
        <property type="entry name" value="DUF6816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20670">
        <property type="entry name" value="DUF6816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6816" evidence="1">
        <location>
            <begin position="78"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="29056" checksum="347AB2C07CC3013C" modified="2009-02-10" version="1">MPVDSDLQLLDCGGSGWRCVDSVASVPSWVLPTSTHAVSTKSGESLATLSALETRLERDILQQLPLTGLSERTGSVDNTYYPDFLEGTWDVTQTLVNVQAPLGANPTPWGIAEDRVYNAIHRLDAFAGRVVVASADYADVAAANRATVLALGGTVQDPLPTVVVRFKGPAAQKTFVTMHAAERVSPTSWIGVEGNRAIFALTNQSTAPPVFTDSELVWKFERLGEGRVRGKLRIVGYLNAQSDKLYFEARNRAVSIQDYTLEMKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1X2</accession>
    <name>B7G1X2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181109.1">
        <property type="nucleotide sequence ID" value="XM_002181073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1X2"/>
    <dbReference type="PaxDb" id="2850-Phatr46625"/>
    <dbReference type="GeneID" id="7201749"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46625"/>
    <dbReference type="eggNOG" id="ENOG502SP2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069475_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1X2"/>
    <dbReference type="OMA" id="CHEHANQ"/>
    <dbReference type="OrthoDB" id="39247at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852911" evidence="1">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="36160" checksum="02F4CDFCC251D6BE" modified="2009-02-10" version="1">MPSTSIVRLLISVLLVMGKAAFAEDYVFIGVSGGLQDGFPDHVKLDYHSGQDDEVRAVFVGRALVRGTKAYLDVMQDGWRQYTSEPGQPLINSVVVVSGCHEHANQYWIYAVDSRQVLAVLNNEPRFLSITPDTGLVDLTVAETDKAVKVLAQSQIQKQGKRNTTHVSFPIVVATWYHESFLPSPPMRHLPDGTAITNFPASLALWAKVNDADRVTGCDYTPTDSSSSIGSNNTVEECEASSRTLAAQRRYWDGIRSAVRAAEADRPSRDVWRANGPPFACERLARLGVDADTARINYSFSAEELHSVFRDTEYRLDLNQAVLTVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G282</accession>
    <name>B7G282_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181333.1">
        <property type="nucleotide sequence ID" value="XM_002181297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G282"/>
    <dbReference type="PaxDb" id="2850-Phatr47033"/>
    <dbReference type="GeneID" id="7202119"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47033"/>
    <dbReference type="eggNOG" id="ENOG502S32Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283937_0_0_1"/>
    <dbReference type="InParanoid" id="B7G282"/>
    <dbReference type="OrthoDB" id="37975at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="35800" checksum="E94AA176F1598354" modified="2009-02-10" version="1">MKSIGQSAESTAAIRRLFAFIESRYGGLPMDSGLMADVITSDKLCERDLVRLVKHEATALHIKGFYHTEAAKKLGSSLAAEASHGKGKNWRVSTSRGLESSDVFTLGEHAPFNIASARGNSSDQDEYFTGVLRELHQRRRSRDDGMQLWPLDLLRLELDEAWPAGAGLARETSGEKRPFSGGLPRVMKGPTRWSKGFIHVDEMGPLDSSKGLFSANIYLQLPSDEVTEAQRVLDIWPMGIRSRWDWYRNALLLTGLSSQDAEAQMRLRKQLGPPASITVEPGDLVLLCVQRPHCAVGFQTGTRVSLQCFLQFNGISERLLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B9</accession>
    <name>B7G2B9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="9">2.1.2.2</ecNumber>
            <ecNumber evidence="10">6.3.3.1</ecNumber>
            <ecNumber evidence="11">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Trifunctional purine biosynthetic protein adenosine-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PHATRDRAFT_47067</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="30">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the GART family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="9"/>
    <dbReference type="EC" id="6.3.3.1" evidence="10"/>
    <dbReference type="EC" id="6.3.4.13" evidence="11"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181182.1">
        <property type="nucleotide sequence ID" value="XM_002181146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B9"/>
    <dbReference type="STRING" id="556484.B7G2B9"/>
    <dbReference type="PaxDb" id="2850-Phatr47067"/>
    <dbReference type="GeneID" id="7202153"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47067"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005361_2_0_1"/>
    <dbReference type="InParanoid" id="B7G2B9"/>
    <dbReference type="OMA" id="EVMQACC"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000013">
        <property type="entry name" value="Phosphoribosylamine-glycine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="21" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="372"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00021140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EEC47105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1237" mass="130343" checksum="077F65038EFB7BD8" modified="2009-02-10" version="1">MSRSCADFVRTASSWKDRIQNRNLIWKFFTGQDPSIFSLGRRRFGVSPSFCYAPCAAVSFTEADTSHPPPTFTSANCLLEFVRVCLTRMSNGMATATALGFGGRAPALVLDLLSRAVHEEGIVTVSPRRSQALPLALMEAPFRTFLSNDNNNNKTESGGGKSPLDLLVYCLPTSVTEYLNAAQEATLVRSKLLYGSSDRQIVVVIYDVHKNAFVGGETAQILDAVGGNNSYRQKLAMASLASLAELDQKAAAQLGPDRQQDSVIVVGAGGREHALAVALAQSPLVGRVLCCPGNGGTAVEGGKIANVPNGQQDNESVVALVKETNAAMVVVGPEAPLVDGLVDALAKECPGTMAFGPTQAAAELEASKAFSKDFLQEHGIPTAKYRNFTDVSEAIAYVESLDESDRQVVKASGLAAGKGVLLPTNKADTIAAVKEIMSDKAFGNAGDICVIESFLVGPEASCLAFCDGKTARLMPAAQDHKRALDDDQGLNTGGMGAYAPAPCVTPVLQRTIEEMCIKTVQKMAERGTPYVGVLYAGMMLTPNGPYVLEFNCRFGDPETQVVLPLLETDLYEILTACCSGNLDAIDVRFKEGQSAATVVCAALGYPEVYPKGMEITGLDAANSSNGVKVYHAGTDVDNAGVTRCSGGRVLAITGTGSSLKNALQSAYNGVKSIQFIDVHGKHQLHRRTDIGKKATQKNLRIGVLGSTRGTALIPVVEACRSGELDAEIVALISNKSSAPILEKGRALGVTVLSKFISAKDLSREQYDSECTAALVAAGVDFVLLVGYMRILSKSFTDFWKNRCINVHPSLLPKHAGGMDLAVHQAVINAKETESGCTIHQVTEAVDGGPIVIQKRVLVDSGDTAESLKVKVQLQEGPAFVEAIKQFSQGATISYADAGVSIDAGNKFVDLIKPLCKATRRAGCDADLGGFGGLFDLAAAGYDSANTVIIGATDGVGTKLRIAQATGKHETIGVDLVAMCVNDLIVAGGEPLFFLDYFATGHLDVHEAAAVVKGIAEGCQQAQCGLIGGETAEMPSMYAPGDYDVAGFAVGAVPRDKILPCSISSGDVLLGLASSGIHSNGFSLVRKLIEKEGLNYSSLCPWEESGVTIGDSLLTPTKIYVRSCLPMIKNGLLKGLAHITGGGLLENLPRSLPSGVSAEITAHPKLPPVFKWMKKASGLSDTEMLRTFNCGIGMVLILSQENVGEARDLLTASGETDFFELGVLVEGVGEVVMKTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2E1</accession>
    <name>B7G2E1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED4</name>
        <name evidence="8" type="ORF">PHATRDRAFT_47085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181362.1">
        <property type="nucleotide sequence ID" value="XM_002181326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2E1"/>
    <dbReference type="PaxDb" id="2850-Phatr47085"/>
    <dbReference type="GeneID" id="7202006"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47085"/>
    <dbReference type="eggNOG" id="ENOG502R963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113240_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2E1"/>
    <dbReference type="OrthoDB" id="47661at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25439" checksum="144EA8A952EB282E" modified="2009-02-10" version="1">METPEVVVRAVDGEVEAMDVEVPNVEMDLLWKTQKAVEMERALTATMRKVEPWLRSSKVNPNQPRVRPIPTSMEQVHQVLAVARNLASRTSAPAGWNPNAPVVGFTTPNPLPHQLRGGALAALQLERARQSERDKKRQREQQKSAELEQAAAAAAARAEQEHQRQLPSELNDPTTGRDPKRREVAHHEVEIRPTSSRPPASALDIASRPAPPQVDVSMNLSDSSSEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3J1</accession>
    <name>B7G3J1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_21682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181799.1">
        <property type="nucleotide sequence ID" value="XM_002181763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J1"/>
    <dbReference type="STRING" id="556484.B7G3J1"/>
    <dbReference type="PaxDb" id="2850-Phatr21682"/>
    <dbReference type="GeneID" id="7202594"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21682"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_2_0_1"/>
    <dbReference type="InParanoid" id="B7G3J1"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="85"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA wybutosine-synthesis" evidence="12">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="416" mass="47258" checksum="2DAD272F7928BD2A" modified="2009-02-10" version="1" fragment="single">MDLEDMGDAMLATQAATVKSKEPREMVTPSQAAALKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGKEWRWKTDDPYFIVDQAVNTHVQMIKEAKGIPGVRMDRWQEAHTVRHCALSLVGEPIMYPRIGELLGDLHRRKISTFLVTNGQHPHAIGTLRPITQLYVSVDAPTQESLIEIDRPLFNDAWDRLKQSLVSLKDKGQRTVARLTVVKGWNSDEIEGYAKLIVLGQVSLVEVKGVTFCGKSDASNLNMTNSPWHHEVVELTRTLKDEIQKIRDKGGDDVPPEYGLACEHKHSCSVLLARVDQFSKVDPATGQRKWQTWIDYDRFQELAAMYEEDPTFTFGVEDYVADTPAWALFGAEEEGFDPTDKRHRRPKKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3T7</accession>
    <name>B7G3T7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181669.1">
        <property type="nucleotide sequence ID" value="XM_002181633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3T7"/>
    <dbReference type="STRING" id="556484.B7G3T7"/>
    <dbReference type="PaxDb" id="2850-Phatr37440"/>
    <dbReference type="GeneID" id="7202359"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37440"/>
    <dbReference type="eggNOG" id="KOG4696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3T7"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="2">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="271" mass="30455" checksum="85E5B8F4C6C7E822" modified="2009-02-10" version="1">MVNKAKEWYPKIGGTYRLMDDVPRGLAIAMRPVLKKRKFKEVIDLCSEDESVETGKRSACSTVKSGVRPTVPIDDGDLIEMSYKKDRINHRPLVYIDTEGGDDSIVSEDCYYPLMEWNKGAARTCAGGDETIKRPSFYLLHIQQRDKWSCGFRNLQMLLVTLVPSLPPEHIYFDNGSLNGQAFRVPSLQQLQASLERSWRAGYDPDGAQHYQNRILGKNSKIGAVEVSTTLVSGQVGAFLLYVLWKGSGLLSLLPDRRDPIVFNYCQAGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3X7</accession>
    <name>B7G3X7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_37482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181516.1">
        <property type="nucleotide sequence ID" value="XM_002181480.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3X7"/>
    <dbReference type="PaxDb" id="2850-Phatr37482"/>
    <dbReference type="GeneID" id="7202382"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37482"/>
    <dbReference type="eggNOG" id="ENOG502R831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251601_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3X7"/>
    <dbReference type="OrthoDB" id="40822at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1253"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1398" mass="155593" checksum="A9721A3546C02FA1" modified="2009-02-10" version="1">MEGRKSRSLSWTLPLWYAFFGACHEFAHLLTAVILGLGRDVWVEGITTVLGRALIERHCVLPGLEDSNASDFNVGVVRHIGWFFSVLLAFGVARTAIPTSKEVRFASFVTALEALSTDLFSLNVLPILTKINSSGSISSVLFCGNFGIILLHQAWLSDNGKSAMDILERMIKVTMMRGAQSGGVVTFQPLKNSLRGMRSRVVNKKRTDLSVLVRKEVERDAIRSVSRPFPESFVQSFSGHTRFATSSKASLDGTHPHLWTPASNRRLYNFSVRRSGPHQYMPETTKVENYITHNGDFDFYIVNGQTFDLEVIQKWLPVVTGFPMPSSVDSCAVAGVIDLLRTQGRFGLSARCAICFGLSTSKMEEELFSFPTYEQFEQIGLVFEEAMDVMLQTTTFSTLCDDPNMRHSFSLCVLSKLKPHRVSLLQPIQRYICDEEEGGANLLSFCLCTINAFFDNDLLMATTTFLKNAKGSFGLCVTSSIDAHRQICLAARGQKMSIAFYPSKGLVCYGSEQASVKAGMNTAFPGAVDELGTSRGDIDADVLRLDLDDLGGEIMCLDWGGKAFRSPAVSLPHRHLIEHVLMKGSVKVVLVQESKTTMQRAQLFHRMTRLSRNPLIKMLAEESKDLVLSDINDTPRACQAIQDDWDSNQTGKSMNRLTAYNLSCCLRKRLEMHLNGPVHNRAVDILLTGCEVSLWLAEQFATDLQKAFPRLRTKAISSNKLLGLYGQELAVPSIGFPYSPRTYDLNDAIVVIVSHSGGTFAPLACSNLLQSTTKNIFVVTSEWDTQIGKQLRTMDGLLDASWDHLFSSRIFSTEVGMRPAEPCSVTVAATQQLLTNLFQYISAVILSDERFRQVVAATISEQDLRILEKCNRENIAALSDIVGVNECGFAIKKQISAEIDLRKAGNLWAEHVLENAKAYIMTFVYIFVTVVSGYHLIYAISYACGLDDTSNFVHLIRVLDAAIYFWLPQINVALLRLFQSRELLHRMGCRTVAIADIPWVAQSAEAFLSKIFACSYSIAGINVLSGNPNDHFVHRHTHRVVRGALVLCGRPDGRLSALATAEATVCLSVNQASSIQSLGGTCESITVGHNPFKLPLTKFGIFLKSNRPQFLCERMLVEKDAEGKRNEDDLAPSPVDQSLQCEGVKNFTQDGQERHSELNMALSSSVHLLPQKTRSASALLGAYTNIAEQADRNRGCNGSSEHSSIDEVLYSAIQERSWSNEGKKLFEALDVNSDGLLSEDEVIDGLYRLETLFLEDHTRAMFKVADGNSSGHVDFDEFLKLLDLADIDGDIKVPSASRDERGNIRIEPSHEEYFGETLRKFNAGKTQNNVEFRLAHSQHFSQELYESRIASLQSGADVRHRMNQLQLQSKIHYSIHVISMAYLRYRARKQSCYPEPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3X8</accession>
    <name>B7G3X8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_42123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181686.1">
        <property type="nucleotide sequence ID" value="XM_002181650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3X8"/>
    <dbReference type="STRING" id="556484.B7G3X8"/>
    <dbReference type="PaxDb" id="2850-Phatr42123"/>
    <dbReference type="GeneID" id="7202383"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42123"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275515_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3X8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="343" mass="38378" checksum="09E244B7E92CF09F" modified="2009-02-10" version="1">MRQRLSVQYFNEAGAREPGIDAGGLFKEFWTDLCAIAFNPNYALFSVTDGAGNCLYPNPSSGAAHGTPDHIVLFEFLGRILGKALFEGITINPRFAHFFLSFLRGDYNYLHMLADLSTVDPQLYNNLMFLKAYEGDTTDLCLTFSIMHDQFGGNKDVLLIPDGANVEVTNVNKQRYVELVAKHYVVDRVKDQSEAFTRGLWEVIDRSWLRLFNEPELQVLISGVSDGKLDVEDLRAHSRYAGGFTGIDRTVNRFWSVLSSMSSKQQADLLRFVTSCERPPPLGFGSLNPPFTIQRVGILRDGDKLPSASTCFNVLKLPTYSSEKVLKQRLLYAIESGAGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3Z1</accession>
    <name>B7G3Z1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hUba1</name>
        <name evidence="12" type="ORF">PHATRDRAFT_54754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181983.1">
        <property type="nucleotide sequence ID" value="XM_002181947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3Z1"/>
    <dbReference type="FunCoup" id="B7G3Z1">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3Z1"/>
    <dbReference type="PaxDb" id="2850-Phatr54754"/>
    <dbReference type="GeneID" id="7202783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54754"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3Z1"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="11">
        <location>
            <begin position="914"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116125" checksum="DDB1E54615F9889D" modified="2009-02-10" version="1">MSAERMEATATAEVDEKLYSRQLYVMGHEAQRRMMASNVLLVGCSGLGVEIAKNCILAGISSMMLVDPTPPTSFDLGGNFYLQESDIGGTKGRAALCKDSLAQLNQYVSVTTADVPDLSVDSVLPLIDGSLTCVVVTVPLPKALVIQLNEACREQKVSFIYSLTMSVFGMAFCDFGDAFVVADKDGEAAATSQIESVVHENPAVVKVLEDHGRHGLEDGDKVSFARLHGVPGLEEGREYAIKTTGPFTFELPEVDLSGIADGDGAGHAVNQQGYITQIKQPVTLKFESYAEKLEKPGELMMSDFAKFDRPPLLHLAFQAVAAYLDEKGELPMPGDVNTAKEVLALANTLDKEGILKSNFQVAERLLMHFASGARACLSPMCAALGGMVGQEVLKACSGKFTPIPGFFYLDADETLPDTLIDSSLVQPTGTSRYDSQVAVFGSDMQENINNLQYFMVGAGAIGCEMLKNWALMGVGCSSKGHVYVTDMDRIEKSNLSRQFLFRNTDIDKFKSATAADAAKAMNPKLNVTAYQEKVAQDTEHLFGDDFYDKLSGVCTALDNVEARLYVDQRCLFYRLPMLESGTLGTKGNTQVVVPHLTEHYGATRDPPEKSIPVCTLKNFPNQIQHTLQWARDWFEGAFKQSADEVNAYLSMPPSQYLETLQPNTKTESLKLLRRTLVDERPLTFEDCVTWARLTFENLFNNQIRQLLYNFPPDQVTSSGTKFWSGSKRCPKPLVFDIDAVDEDAGMRNHFDFVVAAANMRAQLYGIKGRTDEDYFRQTLKDVIVPDFSPAEGVKIAANDEEAKATDGNGMDTGDAEADELWGSLPKPSELAGFRLQGIDFDKDLDEQMLFVTACSNLRAMNYQIPTEDTHRSRAIAGRIIPAIATTTALVTGLICLELYKMVGTARKKLSIDAYKNGFINLAIPFMTLSEPTAPAKTKALVKGKEWEWTPWDSLDMSLGDITMGEFMDYFENEYNLEISMLSHGVSILYSFFANKKKVEERKSMKMTDVITSITKKEFPSNQLFIILEIIANDKDTDEEVDLPYVRFRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G488</accession>
    <name>B7G488_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182033.1">
        <property type="nucleotide sequence ID" value="XM_002181997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G488"/>
    <dbReference type="STRING" id="556484.B7G488"/>
    <dbReference type="PaxDb" id="2850-Phatr37858"/>
    <dbReference type="GeneID" id="7202657"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47601"/>
    <dbReference type="eggNOG" id="ENOG502R0I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048963_0_1_1"/>
    <dbReference type="InParanoid" id="B7G488"/>
    <dbReference type="OMA" id="FYQFIWK"/>
    <dbReference type="OrthoDB" id="1502398at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13960">
        <property type="entry name" value="PT_UbiA_HPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044502">
        <property type="entry name" value="AtHST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009525">
        <property type="entry name" value="PRK12887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43009:SF7">
        <property type="entry name" value="HOMOGENTISATE GERANYLGERANYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43009">
        <property type="entry name" value="HOMOGENTISATE SOLANESYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="404" mass="43487" checksum="A599D76FDA2C58AD" modified="2009-02-10" version="1">MQVIRKMRLELSLLAALWTYLSVGLSSGYALPQPRALTAWTIGSSVVPELRSESYLQALSTIKDSERPNDRELKAATVSAADLSSKENPPFPIVLWRFSRPHTLIGSALAIPALHSLAAPSLQAAMSRINIQAMAYAMFPALLMNIYITGLNQITDVEIDKINKPFLPIAAGILSKKDGIATILLALFGSLWLGAANPVFSTQGLNVALWGSGILGTMYSLPPFRLKRFPLLAAFCIVAVRGAIINASFFAHAKAAAFGGSGVTVLNCLATDPRCYLSSIFFAVFGIVIALMKDVPDVAGDRNSNVRTFSVRLGQGRIFQASRRLLSGLFWTVGVGFGKAAFQAPTAGLAASRSLTAVAAFLGGCSVRKDAQGVDPENAGQVYSYYMHLWKLFYLSYLVLPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4I0</accession>
    <name>B7G4I0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_37949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181919.1">
        <property type="nucleotide sequence ID" value="XM_002181883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4I0"/>
    <dbReference type="STRING" id="556484.B7G4I0"/>
    <dbReference type="PaxDb" id="2850-Phatr37949"/>
    <dbReference type="GeneID" id="7202690"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37949"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_2_1_1"/>
    <dbReference type="InParanoid" id="B7G4I0"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="170" mass="19645" checksum="5605BEE1A3D18A50" modified="2009-02-10" version="1">MSNSNGGYDIRQETINARYRTNPREQDRRERSRSRSPPSRLNDDEEIVRVRLQAERRARMARLRAENDVEEENISSLEGTGDESKKARKKLKSREDSLQVEAEELEGLEEDEQMQLLLGFGGEFGSTKGNKVEDNHSSSARGAAAKHKARKYRQYMNRKNGFNRPLDKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4K8</accession>
    <name>B7G4K8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181934.1">
        <property type="nucleotide sequence ID" value="XM_002181898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4K8"/>
    <dbReference type="STRING" id="556484.B7G4K8"/>
    <dbReference type="PaxDb" id="2850-Phatr47698"/>
    <dbReference type="GeneID" id="7202705"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47698"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335088_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4K8"/>
    <dbReference type="OrthoDB" id="41771at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="548"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="852" mass="96213" checksum="40B60071B093B5AC" modified="2009-02-10" version="1">MPDPERTKSPLRPHSCKAETGDQTSQMHSLLSWMQRSTESSTPTTVASTPDCSDSTQQQTPPSIYDLQDRYVTTGSLAIPEQTEDYDDDDDVMLEERFGGRDLDREISPVCRTGLTVRTRSLPGSPSEVDNSWESRESYASYPIGRKLRSRRKSSTQGIVLKNRRRRRSSRASRDDDDNSLTTLSFSDDPPSPNNDSLPRTIPYRRMSSRRYSPARSLGESTTFRNFVWKLGHPRGLLWLMCVIGLVSISMTYMSTRNMAGRPGEIGRIQVLYAGNHHVPLRTSRLKGGGVSGNFLRGFPAPTSTSIAARKSVPEQGRKSAVTLNHAIVDSRKISEVGVDEHLAKNYALKKNDDRKHLEVHKSKHDEGKHHHSHDEHKHSGNMKDKHHIEHKSTDKNDDRKDPANPEIQHEKRHDSSATNTELENHNEPKNSLTSVAMPLVPLSIPKSDYEAQDWRLYRAPAHSPSNVTHHRMVFVDPSLAHAPLRHRKVVSYPSDYTDPTQLYSILDSGDERIKRMEPRDPYVQGECVPMQPWQTTYHPLCNGVHELGIDQILGEETGSDMRLFGTKGFWRNAWRADILNGHSHLHERDTIVIKTLKLQHNFEEAHFEHDRIDAVAMERLTSSPHVINVFGFCGHTVMTEFADGKRLGELADRAKKQPLERLKIARDIAEGLADVHGIDGDGNVSFVHLDINPANVVSIGGRLKLNDFNIGVPRRWNTTSNEPCGFPTQYPNAQWRSPEEARQEENLTEKVDIFSLGHIFFRMICGHEPWSSFEPGGKPSADELHEKVGRGVLPTIPTNVLESKDPEVVAIRNAMIQCYTFIPSERPSAKQIARNLQKALDKAELVQEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5I1</accession>
    <name>B7G5I1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182418.1">
        <property type="nucleotide sequence ID" value="XM_002182382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5I1"/>
    <dbReference type="SMR" id="B7G5I1"/>
    <dbReference type="STRING" id="556484.B7G5I1"/>
    <dbReference type="PaxDb" id="2850-Phatr47958"/>
    <dbReference type="GeneID" id="7203142"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47958"/>
    <dbReference type="HOGENOM" id="CLU_892713_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5I1"/>
    <dbReference type="OMA" id="HEVFITK"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855439" description="PDZ domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34120" checksum="8D04B3577D4A41A1" modified="2009-02-10" version="1">MMRIFLPTLVAIWAVHAFAFVTPPYPVFLQASPTVLRTASQGATLDQHLMDLAQKFKLEIFDLDEGLFGFDSKDNRYGLEVVHTNIDVGNDGLGLVLTEMAGSPDGRGLVMVSKITGNAAKANPQAIHVGDTITGVMANDGVLKERVTAFNYDKTVEAIGRAKESSTDGTITLELNRLIKRLPVRVEIDDGSGHVQVIEALAGENLRRMFMRKQLKLYDERTRRFDQPFNTGNCGGDGVCGTCLVNVLQGMDLLNPKDSHEVFITKGRPPSWRASCRTTVGFNNVGGTLRISLHPQSELPEELSPGVKSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5I8</accession>
    <name>B7G5I8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182422.1">
        <property type="nucleotide sequence ID" value="XM_002182386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5I8"/>
    <dbReference type="PaxDb" id="2850-Phatr47965"/>
    <dbReference type="GeneID" id="7203206"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47965"/>
    <dbReference type="eggNOG" id="ENOG502S79Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595124_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5I8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="465" mass="50721" checksum="3FC8115091556599" modified="2009-02-10" version="1">MRSTTMSQGFRLALVCYTAVFTPSFQFQGKGQLAFRRRGPQSLPTPIGNSLRAAGSDDNDAPSSDKNLDKNQGMSWTESFNARKEALREEKLAQLKKWCKADCSSAVSVTLPDWIRRLDVAEWPFAACGSSSGSVYIANLETGNLIASNVVQKENDSAHQKGDAVTPIGLEETLRLLYGDHDGGGTFAMTFSGNLICEAGRSGGVNLWRLDSSSQHLVSQGSMMAVQNKLVTCLELDDDYLWVGTSDGLVQAFALDHELPLALQSSPELKWDFGSPVLSLSLLPDIGCGVVSTVSGVRLFSMEDDEEATPIMQPPFDINRQESSVTFALCSTIVCSTENDERTFSVACGGNDGSLFLQPLSMQSHDEVDWKKPFVQPVWQLKPRHSGAVQCMTSPAPGLLVTASQDGTMRVWDIAQRNCMYQFIGYKVWLGSVWSDGVRLISDGSDNTVIAHNFDPAVSEKTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6D2</accession>
    <name>B7G6D2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_2607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182553.1">
        <property type="nucleotide sequence ID" value="XM_002182517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6D2"/>
    <dbReference type="STRING" id="556484.B7G6D2"/>
    <dbReference type="PaxDb" id="2850-Phatr2607"/>
    <dbReference type="GeneID" id="7203336"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2607"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G6D2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF140">
        <property type="entry name" value="INACTIVE PROTEIN TYROSINE KINASE PTKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="103"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="370" mass="41891" checksum="F4D3C20D1CC4B316" modified="2009-02-10" version="1" fragment="single">VNQGDYDKRTALHLASGEGHASIVLALCEAGADPNVEDRWKRRPLDDAFAGGTDGAYEECVAILQRFGAARGLQRSTTSNVNLELDKSSKRQSDNLKINFGELEMIDRIGAGAFGEIYKCRWRGTLVAAKIIKTAKIRKEWNERDLAIADFHQEISVLKSLRHPQIVLLLAYSTTADYEVMISELMKCSLLDVFKSHMVQGTRMRKRTQIIYATQLARGMNYLHTCSPPIIHRDLKPANLLIDHSGVLKISDFGLSKIRPDPGKKETEKYTMTGETGSYRFMAPEVFRHEEYNETVDIYSYAMILFYLLVGRPPWPTISGMNAVKKAAEEGDRPNVPRDMDLRMQSLLKECWDENASMRPAFQRILANLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G794</accession>
    <name>B7G794_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182868.1">
        <property type="nucleotide sequence ID" value="XM_002182832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G794"/>
    <dbReference type="PaxDb" id="2850-Phatr48471"/>
    <dbReference type="GeneID" id="7203699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48471"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G794"/>
    <dbReference type="OrthoDB" id="43002at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55347" checksum="451D5DEB3A500508" modified="2009-02-10" version="1">MYAISDTSSQLNSDPAMGTKSLKLFQPRAPLSRPPLAPPVSASCQPPNLEDPAPEHLNVVEENDLSHHFIPDFNLVSATNFSQESSSCCVSSLGGFLEEEQKSYDERECIPVGFFWRNKQKVSSADVASVGNASDTVVSVDDHQLHLSGRDLHESAKMALNAGDFTKSLSMFEAILMAQAQRFGPCHPSVAAAMHNVGGMHIMNRLNMLFQAVDSSSFLCSLLLVCRQRMGQHDTAENLFAEAVQVRRQTLGSDHLEVAASLSKLGSTRVALQKFDLAFGDLRNASKIATKNLGHEHKTVAQIQSHLACLYFEGGELFAAQATFEDALEIYRAVWSSQESNRDTTMMQLTDTLCNIGSILNRRKRFGDAIHSFSEALDLQRGIFSHNHPRIVQTLDNLGYSYSKNKEYGRALTCYKTMLRMQFSHYGTFNNFCLETFRKEIIMYEKLKRLPEAVNETKETLKLEISVLPRDHTIVVQTKQLLEDLVKRCKRKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7J0</accession>
    <name>B7G7J0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="13">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_15186</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="13"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183027.1">
        <property type="nucleotide sequence ID" value="XM_002182991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7J0"/>
    <dbReference type="FunCoup" id="B7G7J0">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7J0"/>
    <dbReference type="PaxDb" id="2850-Phatr15186"/>
    <dbReference type="GeneID" id="7194700"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15186"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="B7G7J0"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="8"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="959" mass="105395" checksum="8187D17F34334867" modified="2009-02-10" version="1">MDTDTVVWTTDKVRSTFIDFFEQEPRSHTFQRSSACAPLNDPTLLFTNAGMNQFKPVFLGQVDPNSPLANVQRAVNSQKCIRAGGKHNDLEDVGRDTYHHTFFEMLGSWSFGDYFKKEAIDYAWQLLTEVYRLDPDRLYATYFQGDDALGLAPDFEARDLWLRYLPAARVIGCDVRDNFWEMGEVGPCGPCSEIHYDRIGNRDAAAFVNADDPQVIEIWNIVFIQYNREPDKLQTLPAKHIDTGMGLERLVSILQNKDSNYDIDVFQPLFAKLATHTDRGPYTGRVGTDDVDLKDTAYRAIADHARTLAFAIADGAVPNNEGRGYVLRRILRRATRYGQQILHCAPGFFATLIPVVVETFGETYPELRAAESTILEIVQEEEQAFGDMLDRGIKFFTELEGELKENKVLEISGEKAFFMYDTLGFPVDLTELMAQEAGLSVDMAGFANAMETQKTRSRQAQKTARAGNAPVLELVAEQTAWLVDQNVLPTDDGFKYKWDVQLPATVMALYGKDGFLTGDSTADQGDFVGIVLDKSSFYAEAGGQEADVGTLEFLDEAGTITGRFTVTDVQVYAGFLLHKGAVEEGSIAVDQAVNCKVDYERRRMIAPNHSMTHVLNAALRNVLGEKCDQRGSLCNNEKLRFDFAHKRAMTMLEIKAVEEFCQKSVADAQPVKSKVMSLADAQAIDGVRAVFGEVYPDPVRVIAIGDSSSVEFCGGTHLENTAEAEAFVLVEETAVAKGIRRVTAVTKDAAKRALAGGVKFQALVDKIEQLPATTSGLYKQAGSARKDLDAAFVSAVLKAELRTRLEAIQKKANDAAKKALQQRVDLVLNDVKKDVAVALEEKMQTLVLNVDIAADSKASQRVMNTVKEIAPEMAFLGVSEAESGSGGKIMAFAVVPDRLMEEFDLRADEWIRATLESCGGRGGGKPGSAQGQAQDCADVSGVMDAANAFASSKVQSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7L2</accession>
    <name>B7G7L2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183038.1">
        <property type="nucleotide sequence ID" value="XM_002183002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7L2"/>
    <dbReference type="STRING" id="556484.B7G7L2"/>
    <dbReference type="PaxDb" id="2850-Phatr48535"/>
    <dbReference type="GeneID" id="7194777"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48535"/>
    <dbReference type="eggNOG" id="ENOG502SDA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232520_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7L2"/>
    <dbReference type="OrthoDB" id="2276795at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124868" checksum="F29642A62BF5C39A" modified="2009-02-10" version="1">MFKSNASATHRTASMISDISHEFEEEGFGRVRLLAPLSSSRRGPFYEFRLNEMTVNKLQFASLGLYGRDEEIRKLQEVFVKMKSQSRELVMISGAAGTGKSALAQNLQKSVQKAKGFYISGKFDVKQRDEPYAGIVTACRQLCDDVLSLTEPLPEIAPEQTVEPCTGFLPPQSSLYRWNFSFEEMKAKLQQELGQEAEVLSTVIPNLKQIVGGDYLLAPESGVGRLEARNRFNFAFRRFMRVMGSFGPLVMVLDDLQWADLASLDLVQLLITDRENPSLMVVGCYRDNEVHDAHLMTKMIRDIKTSSDEDGVSLTSITVGNLEVPQVDKMLEDLLSSTPKKTMELAEVVHKKTLGNVFYVIQFLSQLAEDELLSFNIGSLKWTWDIEKVLLSTASTANVVELMQKKLNKLPKGVSEVLQLIACLGSTFNYGLFQLVVHHLHAIKPPKIPIESPQVDTSSENPTSNGFRAIDCLNISVNEGIVECCGEYSFRWVHDKIQEATYSLIDRDELVGIQYRIGQLLMNSLTPDDIDTIIFVVVKLLNEGAAAGLATDYAMCDRVAKLNLRAGVKAIETSAFLTATVYLAKGIELLSNDHWNSQYDLSLELYSTAAEAEFCVGNFDRMTNLCNEVLDLSNRPLLDKRRAYNVLLDSLGAQDRMSEASELCLYALYLLNCQLPKYLIKMFVVAGFLRTKVLLKRLTSEKVSDLPTMKEKSKIWAMALLGRLTTFSYLEELDILPLVILKSLRWTLRFGVSEFSPPAFALVGLSLVAHLNDFTGGKVYAQHALSLLESIHSRKVESRTIFVTQAFVMHWTDPIQSTRKPLLHGYQVGMAMGDTESAMWCIYFYLENSMHGGGTLPCLAADLRIYSNQMREFKQSKQLASTLLLWQVVLNLMGESENSVVLTGEAVNQDLTLRQAHDNVHLYAALRRMQLYIACLFEEFELAVGLIKETGINYFEKVMPAVFGLCPLAFLNGMACFAVASKRCGRKYRMLGKKFLRKISGWVEKGNVNVRHYESLLEAELAALDGRRSIALKHYDISILLAGRQGFIQDQAMAHQKLGEFHLKSANMQDAEYHVGEAIKLYEEWGAFQKAHHIKVKHEKLLAPPSEILVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7X0</accession>
    <name>B7G7X0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183089.1">
        <property type="nucleotide sequence ID" value="XM_002183053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7X0"/>
    <dbReference type="PaxDb" id="2850-Phatr39131"/>
    <dbReference type="GeneID" id="7194828"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39131"/>
    <dbReference type="eggNOG" id="ENOG502SCYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1707710_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7X0"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16253" checksum="FD4411C191C078AF" modified="2009-02-10" version="1">MVFYECVLTAKNTAQVVKGGGIVRGIHNHGIRDLPHRFQARYADSQGNRYYQKGRFISIYYDSNPTTMRQVEQTLSMDENVLRNTHLKARSVLDYVNIAREERNPYIKKVHGSQKLKAKAVHERNETVEKVIDDMRTDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8A8</accession>
    <name>B7G8A8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_48767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183312.1">
        <property type="nucleotide sequence ID" value="XM_002183276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8A8"/>
    <dbReference type="STRING" id="556484.B7G8A8"/>
    <dbReference type="PaxDb" id="2850-Phatr48767"/>
    <dbReference type="GeneID" id="7195043"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48767"/>
    <dbReference type="eggNOG" id="ENOG502SWD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1002832_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8A8"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35518" checksum="B7DED10FFDA28654" modified="2009-02-10" version="1">MKRSKTAASDVQQQRWQKTQDEDTLHSLFERKKASIPKTKITLHLIYSLEMLTARTFLRSTLSLPQQRHAWESTGVRTLSSKKPVAPATAKAAVEEDVISPVTVRRAKMSKIDRNMVFGTTGKFLAPVLPENPAEISALDPADQGHRLKMDGTARVVMIRQERASNRQSPLKHEKYWRIFFYEDGMVAEKWTNSLMGWTSNGDPYQSAPPLIFPNAADAVYFAKKRGWNFVVKQPIMRDPREDGAQYQDNFLPLAVAARVQKEGVSCDQWARDHAGTSSYFRPLKYHGDGLVPQHGPNGNAPIAKHVPGYYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8F6</accession>
    <name>B7G8F6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183460.1">
        <property type="nucleotide sequence ID" value="XM_002183424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8F6"/>
    <dbReference type="PaxDb" id="2850-Phatr48806"/>
    <dbReference type="GeneID" id="7195112"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48806"/>
    <dbReference type="eggNOG" id="ENOG502QQJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407412_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8F6"/>
    <dbReference type="OrthoDB" id="43873at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF41">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY (PH) AND LIPID-BINDING START DOMAINS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="411"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="675" mass="74096" checksum="72AD02689F94F87B" modified="2009-02-10" version="1">MAKDTIEPGPSPLLIAFSDHHVSASVTELDHYRIRGGMAVETDYIVTITPLGEESCFDSFTISKTYSAFRTLSHALKKIVDKHTSANEILPQNVIKTAKYCELVKHLIGSQRTEYLGKVNYMYVKIQAKQRSKLLDDVLEATCNYFPADPSVHPLVSEVATLLETFFLTDHCEADETADLHRGASTSSVGSKNAEKGKKNNPLGFLPTLPPFLGKTKKKSARNNMASMVVPITRKVRRPKATRDQDEEELALVGDDAKLLLDDDRPTTELLPNYARPVPVVRTGGTRIGNLIENNPVVFLGIAGGAITVLHFASEAKITMDVDIALLVIFAAFCLGLHTPRPMVGGFDRPPTMKGTFQADGHRKLMRRSMIVAVPVPGEVREEAEEPDIILGSPLPVFPLGAKIGSHNNCWSEPDPATFQVRGDKYLQDKKKMASGEFMFPVRGVDLFLTDTCPENVGSNSSVFGGRLREKPTFLINFRLPWGVLIFYFEIPEKFVPFLQACYEDDFDKSTLAELGPMSAADRTVCRFLMKNMAHKNKTLKIVPVVVAGPWVVKSVVGGKPAIVGNKLPINYLYAPAKDDKACYLEADLDIVASSAARGILSVARTYTQDLTIDLGFVIQGNTEDELPEQMLVGCRLHGVDPLNAASMPPMKDDLMINSSLSADDDSVTPTLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G905</accession>
    <name>B7G905_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_48955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183557.1">
        <property type="nucleotide sequence ID" value="XM_002183521.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G905"/>
    <dbReference type="PaxDb" id="2850-Phatr48955"/>
    <dbReference type="GeneID" id="7195238"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48955"/>
    <dbReference type="eggNOG" id="KOG1171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237953_0_0_1"/>
    <dbReference type="InParanoid" id="B7G905"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF52">
        <property type="entry name" value="CATION EFFLUX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="CRC" evidence="11">
        <location>
            <begin position="1507"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="796"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1447"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1649"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1473"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1852" mass="203138" checksum="C160C88499E97421" modified="2009-02-10" version="1">MFASGDHSRDAAKLLGDYGSVDSDTNANVDVAIDTNERSPHRHQKHHHPHHASLSSFDAPEIYRHGHPHPHYHHSETESATTSSDEPLDEGFVLFGITCPSLRRVALELSLYVNLIITLAKLVAYVQTLSLSVLAALLDSILDVVSQIILNYTEKHSSLQRSSAFYPAGASRLEPIGVLTCAALMGMASFEVLKQSFTALVYHGSHDNDLAPTVGAFVSMLVIVVVKLLLLVLCHRAANKRVTYKGGNTAIGTAAAAIGDGAVITTTTMASKAVVQMADPTLEALSLDHWNDALSNLVAAVALLFTLRSPKFWFLDPLGAILISIYIIYSWYSTGFEQIQHLTGKAAPEDFIDEIMEIAKTFDERMEVDSLKAYHFGPKFLVELEMVMPKNTLLFESHDLGMELQYEIEGLPEVERCFVHVDYETRPYDEHVVSKVPELREKYRPGSNVRLRSTQPARDGVTKNGAADYRATKPRFRVGRMGARSLPLLVLFHYYYYYYYYYYYHHLQFTLLLLSPTLSVGTAARNADLIVRSGIDATVGLACRARLRREERATMLAATHWERGTGACRVDTRRLSLWRGLGSKRVRCSCTRRPFHSVRKSGTRATETDFYRNLTLLCKIRTYSLIGAPLFPRRNVPKPVRANLAGSAHKKGANRDGWRSTARSLRHRGIGGTDCGDPDTFQRLGTTVLALVIAVAVVVPVPVTPPVVTIGIARSVVGVVVWIATVVIGIAGAVLLPLPATARGVLIALLVFAATVASVTFGRNLGVGFQRGDCVPIASHPFQAPQYRCHVRHCRPGTSSRKTHTIRTSPGLPRSVRPNVRSPGTDTPRGPYRTSLRRPAQHLPIQSIWFRVSRDGARYGPGNRLPGTMRVLSSNVPFVWYPTNHCSSLEPAVGSFQYCTVSCRLDRISAWPGLAKILSTLDSPNTFAFFHSLGTFFSLSVAHHSKFPFLPPLAPSLATNHILLFCTIVPTYTHTPPSNTYVSVRIRDLFPINGSDRDSTGNGYRYVSVCNHDSPTPPLPSTTSLFRQRPRPASSTMEASRQSGKDPFAGANLEATFEVDEETDYGFPHHVGSFTDDEFPPRSDMKKRKRRSPMSSPPYVPYASMPLQPFYPPYNSTLGPPQPPGYFPGNVASAAGNTYYGNTTDYYPPLPSNPGYLGPPGHTAWNSPVPKEYSPHRPTALDDTLHAADHELTPEKDQQTRPVFRSPMLRDSKYKRSPLGSPLDQYGSFGMVDTPRATLEDAFSPLGPSFENDLGLSRAERFRGCLELSRSGSSGEFETHPTPQSTAYRPPEPSPFSRLVNEFSPSRGRRGLQGVSRTPVRSAVSDRYAPSHSSRPLAPSMAASMPKAVPRSSIQASPMAPQSGAKPLKLYQGSPAEQQPSTVRMKLDGRGLHSTQRTLNDINSMMRSGSMDRAGVTPYGQSARSPYAHAGMPYHPSYANMVPETSAVKAPRTAHSIRPSPMGSHYGPPPPSSSTSRPSRFPSSIVKTPLAVPGKENPNGITPMSTPRNRCNCKKSQCLKLYCECFSAEVMCEGCNCTDCRNLPAFAAVRAKAMTDCLNKNAHAFKPRIAAAPGAADLQGHSMGCKCKKSECLKKYCECFQAGVLCGLKCKCESCKNIAGSQKLIDKRRQMKDTSGAEFAMRVSQEAWKTGSHTKGGLPGQHVPAPPPAMNRNIRPAAASHHSGGTLAPHPQMPMGYSMGMHMPPFAAMYPGAYHVPPPMHQRLPSPPTVAVAPSAPETVIREATKPEASMITPGDTPRIAALRITFDIEHSRKKRVMNAADEETVAYFGSLPRQPKTTALAIFSYLSNTDVYQCALVSKLWKNLAFDEDLWQFPKSSEKAEPTRDNALTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G969</accession>
    <name>B7G969_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183718.1">
        <property type="nucleotide sequence ID" value="XM_002183682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G969"/>
    <dbReference type="STRING" id="556484.B7G969"/>
    <dbReference type="PaxDb" id="2850-Phatr49009"/>
    <dbReference type="GeneID" id="7195401"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49009"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292950_0_0_1"/>
    <dbReference type="InParanoid" id="B7G969"/>
    <dbReference type="OrthoDB" id="39895at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117237" checksum="3079DEB8A5063578" modified="2009-02-10" version="1">MKDLIVLTSRLSYKIRTYPSNHTLCLWQRCYHETSSADDSIDTQAETCSVASKMSSRNSQLKGHTLQFEEEQCLSSAEVKVSDKKFEPGLTLSALPFLQSSESSGGRSLWKSHKVDDSTPVTVWRQLTLRLLQSTEELTRHECYLMEECLQWWTRRRVKFDVVDPEASEVVWKLWYKLLTESNGKPSSLLLNSVLDHWRLSIKQNIKVPYWPDGVISHVQSLAPELVDVKSFALILGAMAYWYDVDPWKAQALLQELPSHVKPNAIVWNSALTVWAKADALRWPDAALRAEQLLERMKQHPDIQPNEVSFTCVLEALANSPSAKAPEKAERVFQDMEDAGFLSPIACLQVMQVWAKSDSHHGADKAYALLHEMVQLYLKDQSTVKKPMKHCFSVVMEGFARRGKPEKVERILLELQDLYQRFHDDDFVPTAATFNSVLSAYARCALPDRAARAEQLLMSLREMAEWSGNTACLPDTTSVNTVVHAWAESNDKGAVEGAEALLNAMQLWEGVQPDAYTYTAVIKAWARSDRNGAAMRCESFLNAMWAAFEKGNHQVKPNDVTYATVIYAWSRNKGKEAPYRAEALFREMMERHKNGDSTLKPRESSYVSLMTTWNRSNLREAPSRVQFYFNQMRGSHLAGDKSLQPSAKLYNAALFAMKRAGDGAGAENILEVMYADFERGNNKAQPNTHVFNTIISAWANTRTHIAPERAEAIVLRMLELHSDKGWDCKPNAITYTCILDCWAKSSRSDAPDRAEEILRHMQHLSDKGDENVKPTTYAWSTVLTAWSRSTSLDAPVRAQQLFDEMLRKFEAGDKSLRPSGPAYASVLSTWSRSNRHDAPQISSEILKLMKERHLADTLNEKPNRYHYSAVISAFASKGDVQNAEALFEEMKLLKDVEPHDGCYNGLIKAYGRSSLPDAAERAESLLRTMEKESAVGADCSPTMITYTSILDIWQRSQRPDAVDRAESLLKEMLKLAEQGRDKLSPNASTFLAFLRVISKSCATDKAARAEEVLSLMKAFKCAPTDAVFRELNKCRADAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G999</accession>
    <name>B7G999_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183735.1">
        <property type="nucleotide sequence ID" value="XM_002183699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G999"/>
    <dbReference type="PaxDb" id="2850-Phatr39660"/>
    <dbReference type="GeneID" id="7195288"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39660"/>
    <dbReference type="eggNOG" id="ENOG502SZX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404661_0_0_1"/>
    <dbReference type="InParanoid" id="B7G999"/>
    <dbReference type="OrthoDB" id="46311at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853035" evidence="1">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="396" mass="43479" checksum="65681625030C1509" modified="2009-02-10" version="1">MMVFRICFLLALSSSSLLCQGTDCAATSFQSVRRDYHDDQMCDRGTFNKFKESLNRNFQYLQLKQLGNALVPDQKTVVCPSHVHNLHNENDIIGFDSVWIVENTASSPIVLSFVHGDGRESSALNPKISPAQVDPRAVVMPGDYRAVNTFEGHVFHAREMLPDGGAGRVLLQHRVGYIPIGLNQSNAACSGQDLEPVITDALTDETRIAPEYARTPPKPFLDCNALHVGFRNKVGCPVHGFFVEATENDDCHENFKFHLGVNPMTDDFMWSWDSPTKFETSYIGHTFAFRLADRPGVLVDKVTLGPTQISDCPGLAQSFAIPIGADGQLLPVARMLWDASHKTSVYHVNNPGLYRHSNSTASSVLVNTNASLPSAARCAGASSVARERSPLFTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA09</accession>
    <name>B7GA09_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_15757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEC44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="124"/>
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    <dbReference type="GeneID" id="7195552"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15757"/>
    <dbReference type="eggNOG" id="KOG4655">
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    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
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        <location>
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            <end position="173"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="181" mass="21075" checksum="0286154D5A3E56CD" modified="2009-02-10" version="1">MRQLKHHEKKLLRKVDLYSWKGEDNLRVAKVMRRYHIQNREDYTSYSRIVGMITKLSAKLKTLPADNSFRIAMTDQLLAKLNDMGVITTTKSLQKAEEVTVSAICRRRLPVIMVRLKMAESIKNAVTWVEQGQVRVGPNVVTDPSFLVSKSMEDYVTWVDQSKIRRTVQKYNDKLDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA30</accession>
    <name>B7GA30_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
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            <taxon>Bacillariophyta</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183876.1">
        <property type="nucleotide sequence ID" value="XM_002183840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA30"/>
    <dbReference type="PaxDb" id="2850-Phatr49279"/>
    <dbReference type="GeneID" id="7195462"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49279"/>
    <dbReference type="HOGENOM" id="CLU_840622_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA30"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853124" evidence="2">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="331" mass="37156" checksum="12897948B8D9C538" modified="2009-02-10" version="1">MRSFGSVFVAVATVSASSPVHQCPAAIGVAASVRFPDERSVPSLVSQFPRGGSSRQPTWLRKASQMLRPSYRTASNYQKLLQEQRDLLERQLRQTREELAHLRKQVKSNASKSIAVRASNVKAQQGEALRFEETKMLNQQLTELETAMAKLQEMKDRLEALLLEEQEKMAALQVKLEEAETSSEELKAKHEKELELLRAELEAKASTQLAELKKMMKEQMKLALDQQKATAERERQKAILETEQKLQKQAELRLQTEQKKAEEAVEKEKVKMRKLVKALAEREKKLLAAAEKEAAKRTSAGGASSTQASSSSANQKATVTRKTGTVRNPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBJ7</accession>
    <name>B7GBJ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184542.1">
        <property type="nucleotide sequence ID" value="XM_002184506.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBJ7"/>
    <dbReference type="PaxDb" id="2850-Phatr49814"/>
    <dbReference type="GeneID" id="7198383"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49814"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236434_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBJ7"/>
    <dbReference type="OrthoDB" id="47780at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="425"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2034" mass="224536" checksum="2E7E68122BF88A61" modified="2009-02-10" version="1">MVRLLVVSITPKESTHWTISFHTFDLFKTEIRRTTNLIVRACSVQLIAVSSSEDENEIAVWSARPHPGCLLEKGGGKEHVQDISWDYFVFLLRVSPNSVGTTSDKTKIIDFSFLRSGFLDASPSLICYSGKSVSIYQRCGGGRDWEQRTEIYYSNSPTSSSTTMTASAFGSTAPFGVYSNPLDVFPHILPALQCAFASSDESTFLRSDWHPDSFLAEICLDDRGVKAALDDRLRSLFLWLSSVGKDLSDEDLEGPLRVAPLLIVEENFSEDSDGQDQPRARLTLLTGPATDQTLPSQNVAREVSKLKSFRDILLCSIDQAIPESSSTVQSLDCDLGIKKEELPPLLRTLSSEDLEIIWALYDMLVKPPCFDKLDKLGQLFLFTREIFHRLAAITNKIESSISTRIPMPSMHVKITSKSGGSQSCEETYVASSGCLAALMSRSQNKILDCCRANGHKFDWPFARDLRIAFWLRSDRELAKISEEIGQTLYRAKKEIMECALFFVIARKTRTLRNLAAADSTDSGRKLFQFLTSHDFSDERGRRAAEKNAYSLLRKNRYGIASAFFLLAEPPFLKSALEVIVTKMRDSDLAFAVARLTESSVAALQPSLNASSVGLGGILGGGGGYAIPPGSDSSLDGEDGERFDDWQPDLGMYSKKLLVERLLPQAERDNALSAIQLLWLGKIEEASWWLSGFIEPSHDSDTGYRLVNDIDHRVFGTRTDAKRQCAGSMKLSNAIGKVNLLVDFISAPLLLDALGGSQRAQFASCLAVSSALIARGVEMPTIRSLLHLAGSQMLLKHPITCLSPREDAKHGLSPSSAAVKPSISKSLSSSLQPKRSCNLAVAASSGVMSSSVFDSFDTPPTHNSKAKVSDHFERSETVQSSIFDAFDAPPTQNSNPKVSTQEGRSYGMQSSIFDSFDPPPLQNISVTAGRDETSGNIESSIFDSFDVHPGPTVKGSACDDRSGDVRCTAISFDDTRQLFSENDAQESKVLCPVDNRPTIDNQEAIKKSEIAISLSICRKGIPDLWSEWRYNMLLLCAGRRLLREVASVVAQFHGDPRPQSMVSFYHSEHPLVPSRASEVLQLRCDSEKIIGRVKRSLEQLSTASGLETLVVVSCSVQLLGHSQQRRRTLFTVILYAAAQQDDMADLIVRAAASDLIQMAKSMVFCNDVFVLKQKSRSHASTQHIRRLAARLSWQLEICMWLQRGGGLYLSASTIKDAIAAVRVGILIASWNRNTECLEAMIRNQPDCSLDDEAGHPLWTNLKSFTAPEREVKKNRKISSGGWEFLVDCRRTEATKMLRCRPTGCFIMRPHPNDHGVFTLSFKTNLASEEGMPKDGEQQLSDHGELVNRPEQPSSTVMSSRASKRDDIVQHAVVRLSESGFRCGSFGPFASLIGLLEAVSASLPFNLRFDQPPVDRVIQEGFQPSPNAVFFRKLALSHADSGAYPQPAKVQSCQVPSSPKEERTSSTFRTGSEDTRSEKKISFAYFLELTTLSKIHRQLSAVVSVHVDEAHQSDGEVMTTDESYEAASDSVLSLMTFHGVSTPYASSRRLLSPLICWGRSLEILSVEYVAPELNGSFDPRLPVDFEESAEEIEIFQHESATTVEQGDAVLRQMIKRGSGVDFSTLRLSDGGDCTMVVVFGKKEGIEWLLSSGLEASETGALRRLKIMEHENIIEPIEMQRLPLKHKVPEHGESDVRYRIVDPWEVEALPNREGETRGASLGRESFSRFSIGQVALSSESTLRDIGGHSLLELWTSTKGGVLLTKALASIDTPWERAGAGDLLPGNGIMTSVPPYLNSIRQHLYRNALFRRLDLPQRFVALMQVELLDLKNLSSPGGSVSLSTYALLRLKRDGNRAGLTNKTRTLDTAKTHATKLGKSSGPNAPASWGSVVRFRFPLPEDVSVEGSSLDDDRETLFKGPPCVLQITVYEKKLIVDNSLGTADIRTDGLWSGGQLEEWVPLRSDKQTITWFARIRLTLRYELMCHACDAVSMDTISGTSSVGLRRMEELIRAGASAHEDNKQATSSPDLLTYFESMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC91</accession>
    <name>B7GC91_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184758.1">
        <property type="nucleotide sequence ID" value="XM_002184722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC91"/>
    <dbReference type="STRING" id="556484.B7GC91"/>
    <dbReference type="PaxDb" id="2850-Phatr49902"/>
    <dbReference type="GeneID" id="7198527"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49902"/>
    <dbReference type="eggNOG" id="KOG0573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012368_1_1_1"/>
    <dbReference type="InParanoid" id="B7GC91"/>
    <dbReference type="OrthoDB" id="47104at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="466"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="593" mass="65661" checksum="140DAB9AE133423A" modified="2009-02-10" version="1">MRDVLVPQPVDIDIGVSNIVDDDEEGQQHSGTHSCGSCVLAWNGEVFRVVTQTPLGTDTDDLSGSHHSDTTLVADWIRQELTQTVSICREGTTIRSVQLQQQMALARVLERLVDADFAVTLVTPHSVFYARDRFGKRSLLVQDGLSTVTAAGTATETSRSWKLSSVTDGTESAVWTEVAPEMVHCYCVATKQCLPPLSYHQRETMDVAPAQVLHQPLQDEYDKDNIRRAWTTRRINDQSFSSEPCTATSFAPLPSQPTKLETAVATLYVLLRDAVRRRVTGPRVAVLFSGGLDSVVLAALALEILLERYEHTHELVLCNVSFVEDAAPGATDFARTDASALPSRTDAPIPPQAADTRAAMVSYRELERLFPQARICFLAKQATWGDIVRNEAHVRQLVHPQTTTMDLNIGMALWFASLQSTDSKSQHVSAKKVPLGDDCRVLLSGLGADELMGGYGRHRQAWKDGGNEQLRRELDLDLTRLWYRNLGRDDRVLSDTGREARFPYLDTAVVQFLSRLDLDVVCDFKRPPGEGDKRILRVLAAQMLGLEAASTAVKRAIQFGSRIAHVSDKRRFGSRRRASGTARAIHQTAVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCG2</accession>
    <name>B7GCG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184705.1">
        <property type="nucleotide sequence ID" value="XM_002184669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCG2"/>
    <dbReference type="PaxDb" id="2850-Phatr49962"/>
    <dbReference type="GeneID" id="7198651"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49962"/>
    <dbReference type="HOGENOM" id="CLU_301788_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCG2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="288" mass="32765" checksum="B7B437D9F18AD65E" modified="2009-02-10" version="1">MSTEKDFPMPPSQVYNEQQIADSFGTAFDQPKVLEGYVDDNADAEPFRYLSHWYVTDRASPTPMQRVALPADYVFAQKSLSIAGWLQPSTSASKSPASSNLSITAPEPIFVTLDAAEYLAFDRTRRYRGYWVGTADALYWLQQPETMRWNGALSQQDLHVEWRAALALLSNLLDLVFTDERTAAVYARSTMLDTYKALTDQRGYEPFDKELLVHLRKLVKPHLLEAHPALLQDCKFLRSLMTYKPPKLDSLTPERILESIAVAEARSQIHPWVRKDQVKPATPLQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCN4</accession>
    <name>B7GCN4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_16442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184835.1">
        <property type="nucleotide sequence ID" value="XM_002184799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCN4"/>
    <dbReference type="FunCoup" id="B7GCN4">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCN4"/>
    <dbReference type="PaxDb" id="2850-Phatr16442"/>
    <dbReference type="GeneID" id="7198722"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16442"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GCN4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="99"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="168" mass="17073" checksum="667397BA81B4F2EE" modified="2009-02-10" version="1">MDFDQCPAIAPFFGFLGVAASTVFANMGAAYGTGKAGTGIMISGISSPDLIWKNLIPIIMAGVNGIYGLITAIIIINQIVTPTQDGLGTYSLYTGFAHLASGLCCGLCGLGSGMAIGLAGDAGKKAGGGDQLFVAMVLIQVFAGNLALYGLITSIILTQTSYVCEYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCY7</accession>
    <name>B7GCY7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185037.1">
        <property type="nucleotide sequence ID" value="XM_002185001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCY7"/>
    <dbReference type="PaxDb" id="2850-Phatr40979"/>
    <dbReference type="GeneID" id="7198822"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40979"/>
    <dbReference type="eggNOG" id="ENOG502SRU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1009945_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCY7"/>
    <dbReference type="OMA" id="YTDAWIL"/>
    <dbReference type="OrthoDB" id="43192at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853143" description="N-acetyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30941" checksum="2656E5F498F34D71" modified="2009-02-10" version="1">MILLKALACLLILLATCVFYTDAWILSGPEPKRKRIPYRVYLDHLDPSKLIINDESSSPSFRSEIADGKHKNSCRKLDLSWTHNDVLWKIRPPPETPWYQHILLRFAANGIRLDCALKGAPEPLLLCPKGGQAVLEAWTKDGSTKVGRFGITTEPGPLTPPIQETVQTIYGLDANVAVRTAAIIYMFVEEDFRKRDIGVLALQVISLIHAYQGCDFTVLVADDKGSGRLIEWYGRNGFALAPNLQDIMGSPDRIYGTTMIGPTNQTLPYDCQIKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD39</accession>
    <name>B7GD39_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transport protein Sec61 alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Sec61alpha</name>
        <name evidence="13" type="ORF">PHATRDRAFT_56443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184983.1">
        <property type="nucleotide sequence ID" value="XM_002184947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD39"/>
    <dbReference type="FunCoup" id="B7GD39">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GD39"/>
    <dbReference type="PaxDb" id="2850-Phatr41031"/>
    <dbReference type="GeneID" id="7198846"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56443"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_0_1"/>
    <dbReference type="InParanoid" id="B7GD39"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="559" mass="61889" checksum="0D20641CC33D630D" modified="2009-02-10" version="1">MVCRKVKIPECLRAAWQDFDGQTDRIRSAASTRNDFVPAFPGNKLLPRPQLWRQRQAPHAHTIPNRCGLLPSPRLVCCGCTLAFVATMRFLHLIRPVMCVLPEVASPDRKIPFREKLLWTTITLFIFLVCCQIPIYGVQSAKSSDPFYWMRVILASNRGTLMELGISPIVTSGLVMQLLAGSRIIEVDYNVKEDRALFSGAQKLFGILITTGEAIAYVVSGMYGDLGSIGAGNAILIIAQLFCAGLIVLTLDELLQKGYGLGSGISLFIATNICENIVWKAFSPTTINTGRGTEFEGAIIALFHLLITRSNKIQALREAFYRQNLPNVTNLLATVLIFVIVIYFQGWRVNLPVKYQKYRGQEGNYPIKLFYTSNMPIILQTALVSNLYFVSQLLYNRAPTNILVRLLGKWQEVEGSAGNKIPVGGIAYYISPPQSFAEIIYDPFHAVFYLVFILTACALFSKTWIEVSGASARDVAKQLRDNQMVMKGHRDSALIHVLNRYIPTAAAFGGMCIGALSVIADFMGAIGTGTGILLSVTIIFQFYEAFVKEQKEGTGAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDF3</accession>
    <name>B7GDF3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185202.1">
        <property type="nucleotide sequence ID" value="XM_002185166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDF3"/>
    <dbReference type="STRING" id="556484.B7GDF3"/>
    <dbReference type="PaxDb" id="2850-Phatr41150"/>
    <dbReference type="GeneID" id="7199097"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41150"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800411_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDF3"/>
    <dbReference type="OrthoDB" id="189234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF142">
        <property type="entry name" value="FAM86 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855782" evidence="1">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="39410" checksum="36C2C23A9B605B1A" modified="2009-02-10" version="1">MNIVVFNVTFWLVTLTYPIRDHSQSQQLRGREELRKSTRNVIRRPHKTSLDFGSQSIVPPSLYCANFCNGIMRHLAEADWIERLDPPSHRFRIYQSMDDLSVYEPEYEPEEVVIANGKVRLQVLSVVPPPLEYMATLHADRQEISGRQVWTGSLALAHVLEQHEPAKRDLQAKRILELGSGTGILGMSVSKLFNPEIVVLTDGDPKAVELLEQNLDNPFNEIDLAKTRLETLVWGNVKPSFAKSCRAFGPHWLEAEKVQFDSILGGDVLYKNELPVLFFITVKCLLKPNGVLWLCHIPRSTVTQEVVVNAAKMAGFQWEVVDFNSKIQGCPVEDANRARVYRLKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDK5</accession>
    <name>B7GDK5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185145.1">
        <property type="nucleotide sequence ID" value="XM_002185109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDK5"/>
    <dbReference type="PaxDb" id="2850-Phatr50287"/>
    <dbReference type="GeneID" id="7199042"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50287"/>
    <dbReference type="HOGENOM" id="CLU_601983_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDK5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="455" mass="51501" checksum="40885D43999C25EF" modified="2009-02-10" version="1">MARKRARASLQQGTATILFRDHHSPHTDTAMESLPSQDSPKHPSGRRVRHCRICGVPQKGHACPYKDERRSYAVADADDRHHEPMFRAGSKVYNCQLCGVPKKGHVCPQRRETNSSEYVRSTAVGHTVNGNAKPSQKRRRLSLLEQLPFCDQASEKNGTTVAADILPRPARIYQCTRCHVPLKGHVCPYKHPSISFQSKPPASFARPAARQESTDWESDSDGNEEKLSLVHHLSSAPNDKLSDEASLSSSSSSEILGMPMSGKGSDDDESFSDRPSRTKTNSFRKSPARYANGKKVRLCFRCGVPRRGHTCPYASHNREKSLYRNEWTEAMAPGHVLYDQVCAYIDRQGHGLADHDRAFLIQWAGNVNSSLFEEDKLIWENIELVLERRRQSKATRKQQDTLIRMQSSIRHIQSTIKQLEERIAMQRHETNKRRSASRFLDALERIQGRNKTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDR4</accession>
    <name>B7GDR4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_4708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185175.1">
        <property type="nucleotide sequence ID" value="XM_002185139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDR4"/>
    <dbReference type="STRING" id="556484.B7GDR4"/>
    <dbReference type="PaxDb" id="2850-Phatr4708"/>
    <dbReference type="GeneID" id="7199070"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4708"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_9_1_1"/>
    <dbReference type="InParanoid" id="B7GDR4"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24138">
        <property type="entry name" value="TtcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="24846" checksum="EE11FF9C1579BDCD" modified="2009-02-10" version="1" fragment="single">KREKSKHIKPPPKMMRLVTQAVMQWEMLEEGDRLLLGLSGGKDSLSLLHCLLEFQKKLPIKFEIEVCTIDPMTPSFDPSPLIPYINTLGLKYHFIKDNIVSRASSSGKDGKVVSSLCAYCARMKRGNLYACARRNNCNKLVLAQHLDDCAESFMMSVMHNGFLRTMKANYQINAGGISVIRPLAYCRESLMTEFARSANLPVINENCPACFEEPKERARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3L2</accession>
    <name>B7S3L2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_bd1558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176149.1">
        <property type="nucleotide sequence ID" value="XM_002176113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3L2"/>
    <dbReference type="STRING" id="556484.B7S3L2"/>
    <dbReference type="MEROPS" id="S08.050"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1558"/>
    <dbReference type="GeneID" id="7204906"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1558"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_1"/>
    <dbReference type="InParanoid" id="B7S3L2"/>
    <dbReference type="OrthoDB" id="47834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002860780" description="subtilisin" evidence="10">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="146"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="526" mass="54546" checksum="0982A549D270DCC2" modified="2009-02-10" version="1">MTLSQSFALLVAANFVGVAFAQQLSEHRKLNRIVGGQAIPGQYIVQLDKRIPDSKGFATKVLKRALKSKVINTYDYAFKGFAVANLPDTVLSVLLNLNEVRDISEDGVVTIDAIQSKPVWGLDHIDGVDDDMYEYAYTGLGVDAYIIDTGILASHADLEGRVASCISFTGEACGFDLHGHGTHVAGTVGSKTYGVAKQVSLHDVKVLNVNGTGSYANVIAAVDHVTKIKQENSTRKIVMNLSLGGGISTALNTAINSAVDQGIAVAVAAGNNNQDACNYSPASASKALTVGAMTITNARSSFSNWGSCVDIFAPGSSIVSLSSTGGTSTKAGTSMASPHVAGVAALYLEAGRPVSKIVADAATDRLSDLSSSSNSLVSTALLGESIPPVIAPTQQPTLGPAKESISLTKGPALVPTSVPVSPPSKAPVRPPTKAPVRPPSKAPVRPPTKAPVKPPVRAPVKPPVRAPIKPPVKPPVRAPVKPPVRAPVEPPVRAPVRAPVKPPVRAPIKPPVRAPVKPPVRAPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7S487</accession>
    <name>B7S487_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cysteine synthase</fullName>
            <ecNumber evidence="4 12">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CysK</name>
        <name evidence="14" type="ORF">PHATRDRAFT_bd542</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 12"/>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176406.1">
        <property type="nucleotide sequence ID" value="XM_002176370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S487"/>
    <dbReference type="SMR" id="B7S487"/>
    <dbReference type="STRING" id="556484.B7S487"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft542"/>
    <dbReference type="GeneID" id="7204863"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd542"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="InParanoid" id="B7S487"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000067">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000130">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 10 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="336" mass="35114" checksum="85992F698A320509" modified="2009-02-10" version="1">MSSSTSRSFSLNAKIAENVLGLIGQTPLVQLNRVTEGCVAQIVAKLESSNPANSVKDRIALSMITEAEKRGDIKPGKTILVEPTSGNTGIGLAMVAAAKGYKLKLTMPESMSMERRVLLKAFGADVVLTPAAKGMGGAIAKAEEIVNSLGSDAMLLQQFNNPDNPKVHRETTGPEIWSDTDGEVDIIVGGIGTGGTITGCAQYLKPLNPKLQVVAVEPTESAVLSGGKPGPHKIQGIGAGFIPGNADTSLLDEVVQISGEDSMAMARKMATEEGIFCGISSGAAVLAAIQIGKRPENADKRIVVIIPSFGERYLSTALFQDLWDEMAALKPESVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4D8</accession>
    <name>B7S4D8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176433.1">
        <property type="nucleotide sequence ID" value="XM_002176397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4D8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1463"/>
    <dbReference type="GeneID" id="7205037"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1463"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_0_1_1"/>
    <dbReference type="InParanoid" id="B7S4D8"/>
    <dbReference type="OMA" id="QNAHYID"/>
    <dbReference type="OrthoDB" id="38169at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="322" mass="36604" checksum="CCF925626A176967" modified="2009-02-10" version="1">MKDNTVSPTTTPNLESLRLEDSILLPEVPENGIMSKMASNVTFYEGMTEDEEDAIWESRRLGTGHHQRQLSFSLPEDMQAVNRHATDLFKSLAQRVVTTYQSRKDDLQNGQLFIAVAGGPGSGKSTLCEKVAQRVNARLEPGIAVVLPMDGFHYSRESLRKMAETEACVYTYEQLLQRRGAPWTFDHDLCAEKFKQARHHGEGSFPVYSREKSDPVPDGVQLMMTHKIVFLEGNYLLAWDDPNWSSLQGVFDEAWYVACTTLEEQRERLINRHLSNWTEEKIQMWGEGHIGAGRKADSNDVLNSAWIDHHSRKHADLIVESK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0J4</accession>
    <name>RK18_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL18c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>50S ribosomal protein L18, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpl18</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; contacts the 5S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874469.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0J4"/>
    <dbReference type="SMR" id="A0T0J4"/>
    <dbReference type="STRING" id="556484.A0T0J4"/>
    <dbReference type="GeneID" id="4524644"/>
    <dbReference type="InParanoid" id="A0T0J4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000003">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_uL18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_uL18_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000276393" description="Large ribosomal subunit protein uL18c">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="135" mass="15414" checksum="02949138DF9C52B8" modified="2007-01-09" version="1">MKFSQRTLLKLKNKNKKLRPNKYKKLKRETLRGRIKGTVERPRLSVYRSNENIYAQIIDDTNSKTLISCSTLDRSIKLVISTGRTCDASRLMGEKLAKLSLKKNITKIVFDRGPYLYHGRIKAVADGARAGGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3B8</accession>
    <name>B5Y3B8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_13399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185622.1">
        <property type="nucleotide sequence ID" value="XM_002185586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3B8"/>
    <dbReference type="STRING" id="556484.B5Y3B8"/>
    <dbReference type="PaxDb" id="2850-Phatr13399"/>
    <dbReference type="GeneID" id="7204575"/>
    <dbReference type="KEGG" id="pti:PHATR_13399"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224718_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3B8"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="252" mass="29192" checksum="9B14004630686C4A" modified="2008-11-25" version="1" fragment="single">MSNWKAKVIADWRLGKLSNFDFLMHLNSFAGRSFNDLTQYPIFPWIIADYDSDEIDLDDPNVYRDLSKPMGAIGAERAQQFQDRYEALASCCTDEDPPPFHYGTHYSCAAYVLYYLMRLEPFSRLALALQGGKFDVADRLFHDVGRSWKSASTENLQDVRELIPEFFYLPDLFVNANGFDFGQTQAGKSVHDVLLPKWAKGDPKRFVRINRQALESPYVCRHLHRWADLIFGFKQRGPEAVRCLNQFVHLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3H6</accession>
    <name>B5Y3H6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_28147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185657.1">
        <property type="nucleotide sequence ID" value="XM_002185621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3H6"/>
    <dbReference type="FunCoup" id="B5Y3H6">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3H6"/>
    <dbReference type="PaxDb" id="2850-Phatr28147"/>
    <dbReference type="GeneID" id="7204609"/>
    <dbReference type="KEGG" id="pti:PHATR_28147"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_1_1_1"/>
    <dbReference type="InParanoid" id="B5Y3H6"/>
    <dbReference type="OMA" id="CFRQCAK"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7266" checksum="9CCCA7FB7272C14C" modified="2008-11-25" version="1">MAESRKPNKLYATHPKNYGKGSRQCRVTGRMGGMGLIRKYGINMKRQVFRERALDMGWEKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y508</accession>
    <name>B5Y508_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186100.1">
        <property type="nucleotide sequence ID" value="XM_002186064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y508"/>
    <dbReference type="PaxDb" id="2850-Phatr33339"/>
    <dbReference type="GeneID" id="7204202"/>
    <dbReference type="KEGG" id="pti:PHATR_33339"/>
    <dbReference type="eggNOG" id="ENOG502S1N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117906_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y508"/>
    <dbReference type="OMA" id="WSDERII"/>
    <dbReference type="OrthoDB" id="45866at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19055" checksum="D7DEEB28277DB0ED" modified="2008-11-25" version="1">MSSNYRRVPTASDAASTASSDMGEAGTNPSPADGDNRAYLSRSPADRMADKAIALAWVLVAWLVAKWTRFFHVLLADERANRPLLQVAALSFGINTVLLLYLTVYLPKIKGLTDSSAWEVYCPRVVPTMTFVGVVTGLLLIRATWPVWGFLAPLVLGVEFLGLLFGLHFVPWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5G4</accession>
    <name>B5Y5G4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186464.1">
        <property type="nucleotide sequence ID" value="XM_002186428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5G4"/>
    <dbReference type="PaxDb" id="2850-Phatr33499"/>
    <dbReference type="GeneID" id="7204052"/>
    <dbReference type="KEGG" id="pti:PHATR_33499"/>
    <dbReference type="eggNOG" id="ENOG502TAHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113165_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5G4"/>
    <dbReference type="OMA" id="FRIAVYM"/>
    <dbReference type="OrthoDB" id="10262585at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841156" evidence="1">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="250" mass="27217" checksum="6B91FC76F4C6ABC7" modified="2008-11-25" version="1">MGTGSFRYYLLLSVVLAKACVSRSFGLVQNSYRIVGIPGAGTQLLPESYIKGIRRWTLDDSGNDLVVVPNSPGLTNPKRDLQGQRIQIRPTLDVLVKSGVPSYVMAGLQVRHEKADEEDQSSQALEPPLTAEQWTTFAMAVDPSFRIAVYMGPSDGTDDRVAMADHDLIQHALERLGLFLSQATEELSGGFHIVALPLEVSWTRCSVNSVDDILTCLATAEPDARELLTLDQGLVEMTASSVLQVTLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5U2</accession>
    <name>B5Y5U2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_10518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186248.1">
        <property type="nucleotide sequence ID" value="XM_002186212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5U2"/>
    <dbReference type="STRING" id="556484.B5Y5U2"/>
    <dbReference type="PaxDb" id="2850-Phatr10518"/>
    <dbReference type="GeneID" id="7204141"/>
    <dbReference type="KEGG" id="pti:PHATR_10518"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627736_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5U2"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="125" mass="14188" checksum="094BCDFC97C127AB" modified="2008-11-25" version="1" fragment="single">VDGAERTWDRDLWEEENSVVKKISSSADALEIKKSGKPAVIAVYAPWCQFSQAMEDQFEEFAKAVGDDVDVYSFRGDEEREFVMANLNTNSFPTVNVIKADGTAVKYESEERTVEAFKKFMEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNT8</accession>
    <name>B7FNT8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SSDH</name>
        <name evidence="5" type="ORF">PHATRDRAFT_31599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177097.1">
        <property type="nucleotide sequence ID" value="XM_002177061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNT8"/>
    <dbReference type="STRING" id="556484.B7FNT8"/>
    <dbReference type="PaxDb" id="2850-Phatr31599"/>
    <dbReference type="GeneID" id="7195958"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31599"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="InParanoid" id="B7FNT8"/>
    <dbReference type="OMA" id="PFGGEKH"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07078">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="471" mass="50995" checksum="F15CDA242954BF53" modified="2009-02-10" version="1">MVQGVAVVDGSIINKNPATGEVISRVPCTPLDELDVMIREAKLAQKSWATTPVAKRIQLLRDGLQAIEAKSGQLARCITTEMGKPIAEAREEVEFAVGKAEYLTLLEASLQPQQRGSCTVIRQSLGVVTVLSPWNFPADEILLLLLPALGSGNTAIVKPSEVSPETGAIVVNCLAQFLPENVLQLAQGDAQVGAHLVSHKDVDMVAMTGSSATGQKILTAAAPHLKRFVLEMGGKDPMVVFDDADLNQAAKDAVSYSLSNTGQVCCSIERIYVAQTIYREFQERVTRCAAEYHVGNGMDENVNVGPMVSIRQRDHVKRHVEDVIAKGAKVLHQSKIPSTASTESSFFPVTVLADVKENMHMYHEETFGPVVALTPFDGSEEEAIRLANDTEYGLASCVYTQDMDRAQRVASAIEAGQIGINCYSLENMDVACPWVGHKKSGFGYHSGQEGFHQFSIPKTLVYVPSAHSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP50</accession>
    <name>B7FP50_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176646.1">
        <property type="nucleotide sequence ID" value="XM_002176610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP50"/>
    <dbReference type="PaxDb" id="2850-Phatr31713"/>
    <dbReference type="GeneID" id="7196017"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31713"/>
    <dbReference type="HOGENOM" id="CLU_1573690_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP50"/>
    <dbReference type="OrthoDB" id="45198at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855236" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="170" mass="19002" checksum="8314C983A2E30412" modified="2009-02-10" version="1">MIKVQGRITLFLLVLVRASSFASWLRCYIDLDDSEIIMNYQVLLPEDAPHLVHIEVSADGETWTDSFSFPAEAKTSIRARLRVPEELIRRDVQYVIESTNGGTFHDPAMCDGVRSHASAHDESVGLVIDGSVSERIELWAAWASGHEAVSLTPRLLLRRDDLIATEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPE3</accession>
    <name>B7FPE3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_42751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176697.1">
        <property type="nucleotide sequence ID" value="XM_002176661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPE3"/>
    <dbReference type="PaxDb" id="2850-Phatr42751"/>
    <dbReference type="GeneID" id="7196131"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42751"/>
    <dbReference type="eggNOG" id="ENOG502SQK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPE3"/>
    <dbReference type="OrthoDB" id="48488at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="572" mass="63167" checksum="5F434745109DAA86" modified="2009-02-10" version="1">MKLEQEIRIVSGNADSSAESDILDTHEISIQLSGTTSTNESDHSSFRPSVDDTSVEGCSIEQEDQLPIMKIKDKDNVGSRCYLIFCRGWYGCHGYSRVIEAWPRTSAFVFGVVVPLFTLVAVALLFGFFLSKLEGPPEIEANDHLLAAHTEAETLVTIVSNFTGLLPQLCIKLYFDNHSILELGPALFDRLVDGALDESEDLKVEQLVNRSLLSIDTEELYTYMEACGNDAKPITSFLAERAANASKRVSGDLSFNWVRCYPGADGLGGTGQSDIWATGQSIEEIRPAAQVQHFQRVWELDRQRIYHETLRESLKDPHYRGSAGALRLAAFDYSIAQASGAVGCELNGVSATWFWFTVMTTIGRAQNSIFLGYGNHAPVTDGGRTMIFTLGFMSVILFGAVLSQAGAVVSAILDDSVKRIRLQVLSWPSVSCLIWGSLYYAWMLVIAFVTQQWKVGRLGEAFPFNEGYWFAFISTTTVGLGDVFLEPEVIRGDDLIVFPPLFLIGFVFFAAFLRKFAEMVLFALAKENKKTLIQSLLSRLESTNGLPTVLIAPGMDPDADNERKDPQESIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPF2</accession>
    <name>B7FPF2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_31816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176704.1">
        <property type="nucleotide sequence ID" value="XM_002176668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPF2"/>
    <dbReference type="STRING" id="556484.B7FPF2"/>
    <dbReference type="PaxDb" id="2850-Phatr31816"/>
    <dbReference type="GeneID" id="7196133"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31816"/>
    <dbReference type="eggNOG" id="KOG4436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492179_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPF2"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="129"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="554" mass="62502" checksum="699CFE6061CFC3AE" modified="2009-02-10" version="1">MIFAQEAGDSTEIVRAIYEALSTLPDVSLLSQPETDKEEASPPSITFQPEICRSTSSNLSIGKRYNAPCEQPSPFEISLSTFPAFLSFVLDFLGDPVAVCRFKMVNRLCLKYVDEHEHVLMRDAVRLGGLQINVRPSFWLWVTLEKDSRESCHRKEDPDDNVIMGARNELTLLERKGREGKWNNVIHRDVLRSFGNLPPHKSGARLRTDSIVRALATWGRSRILKSGIRGSGDPPPPSHSFYEEDDDDVSLAPTDTVSDWGAVSPVGSVTGSFCSTRLDGRHTKKFERQAEAQELALGGSALSDIAKARLQEKLSFILHVLAATYSNVGYCQGMDYVAAHLLRILEDTIRWKAVTGNLPSVIQFEPSSMIGHDNPDQSLSDMYAEVDKSSVVEETCFRVMDSFFTTYGLRHFYWPELRCLKTCCLVFEKLVQIKLPVLADHFEHHELNIGLFALGWFQTLFLYLPSMPAATVCHMWDIWLVERNFKIFFRVGTAILFLCQPVLLNNELEGMMGYLNTFPDATLLSPDILIACALQIKVTNRMLTQIECDLYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ14</accession>
    <name>B7FQ14_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176803.1">
        <property type="nucleotide sequence ID" value="XM_002176767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ14"/>
    <dbReference type="STRING" id="556484.B7FQ14"/>
    <dbReference type="PaxDb" id="2850-Phatr32036"/>
    <dbReference type="GeneID" id="7196550"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32036"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_1_1"/>
    <dbReference type="InParanoid" id="B7FQ14"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90797" checksum="F170CFAEC5E9C9B0" modified="2009-02-10" version="1">MKTALDKGTVTKKGKLRKRKKQTVPSNLSSNSKRPAETTENLTSHPDDFTSRENLGDLDLDDFFATVAESIEKEEEENSVSSVEGEADLESDDEQAVGASKKPKQEDSVSDSDRSNSDDEDVDNAEARMKEEMAKMEKADPDFHKFLKENEESLLEFGDAHGENGEDNVDTETLDDEVIENEKEGEHRKGQPAVVLTPVVLKALYQGTFVSHGVTSLKKLVSAYRAACHLADSTSEDDKKAPREDGKDYIIESSKVFDQLMLLCLNRCHEEFRFHLLGEEKAENEEEITIETTRQESDENKPINPSKLSKSGKWDNIRPIILSFFRSTLHVLDEAKEPELVTVIVKALSKYIPFLSAFERIAEGMLKALTALWSAPLDSSEDYQVVRLNAFFRIRQLALTQPFPFVETCLKKIYLAYARRAKLGVSSSATTAMPTLTFMGNCLVELYSLDYHSSYQHAFVYIRQLALLLRAAMQKKTKESFQQVFCWQYVHCLKLWVAVLSQAAPTDDGAMMRSLIFPLTEIIQGTCRLVPAPVRHVPMRFHCIRLLQQLAAASESFIPTTSFLLECLDWKEWYLSPKKVKGGGGATRGLQMQYLLKLGKDDALRTQEQLEPAISEWFVLMQREIELYRYSAGFPEFSIRIVQRLKLFCKETRNARWRTYARGCIDTCDRYRVEAVAGRAKLQEAPKDVNRLECLRPHGVPAMGNRLQADIDKEAKALQASQSAVPSVKNCNKRKSDDGPEQDAAGNEEDKTESKSTKRRRKKKEAAAKKNQNQEYEIVGEEVLEQKDQVKEGIDWSDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ56</accession>
    <name>B7FQ56_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177334.1">
        <property type="nucleotide sequence ID" value="XM_002177298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ56"/>
    <dbReference type="PaxDb" id="2850-Phatr42960"/>
    <dbReference type="GeneID" id="7196202"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42960"/>
    <dbReference type="HOGENOM" id="CLU_600613_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ56"/>
    <dbReference type="OrthoDB" id="46823at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852542" evidence="1">
        <location>
            <begin position="21"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="456" mass="51107" checksum="1D8222A21BA50870" modified="2009-02-10" version="1">MAIKHSVLAVALYWLTPAQSFQLKPMSPKNRISLSSINHVIRKAAVVSTNEAAETRPKRGWKKLKRIFRRGKSEQPVHMQTPSALHPRTVQARNLACWSPENTPAIDDFLVHPDESVDRPHHTQDKRIKALEPFEQPYVVPEPNWGKSKSISDRYFASLFPALRQILLKEKSIEEKPDSIAPLAKVLRTKSRTVLFELLNRWSLGAHINMQVQCDPQGSLLDIVRQGVFCCNASVDVDRIVFGAIRLSGCRLEAKSMSLNLHRLIRPSQRNIKRFPRAFDFVANNATFTQADLFESSCVTNGLRRLVVRILKGRGLEPANVFMDAIKILPNGKLSCQGHATTIFDAAVPFEVRTHIETSCRGHILNFPGLQMSVGPTTGVFLPVIPDVSLDLGHNAQVLDVNLDGAKAQLIMSARVTIAPEHTRKLQNYTQRANAYGALFSVDLGRWLTRVGRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQK0</accession>
    <name>B7FQK0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_43081</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177416.1">
        <property type="nucleotide sequence ID" value="XM_002177380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQK0"/>
    <dbReference type="STRING" id="556484.B7FQK0"/>
    <dbReference type="PaxDb" id="2850-Phatr43081"/>
    <dbReference type="GeneID" id="7196865"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43081"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_630865_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQK0"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="43633" checksum="D16E61F7F63ECD50" modified="2009-02-10" version="1">MNNMAHAAMESMDMPSALPSSLLAAAAVPANATPASARRRRTSRRERGLHPATLKLEIVHGTDIVYAVHGTSAAFDGLEDKDELVRTMQRWGCDHLKLSPPSVLINWDVTHEECLNVVGKQLPAVESNKDANVVAVLKEPMGSQGQGIFFVKNAEEIHVVIEEHRQRAEAEPAFLDNLIEAKGRIPSWVLQAEVVPSLLIFDGRKFHIRTYVVAVENLDHPDLVDVFVYNRHEVRVAGVPVPPDGGTERDRKAYITNGALSTTTQRVLIDQVEELMSRNLKSATEAFVAETFGKHLLPDFGGRVRCTQLDNDGPTPIRKFAMAGLDLMVTEDNRLYLLEVNANPAAPRENTITEDFANHLKGFWRDLVNLVTDVDAPNFVPVKDILQQHGLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR73</accession>
    <name>B7FR73_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176991.1">
        <property type="nucleotide sequence ID" value="XM_002176955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR73"/>
    <dbReference type="STRING" id="556484.B7FR73"/>
    <dbReference type="PaxDb" id="2850-Phatr43274"/>
    <dbReference type="GeneID" id="7196981"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43274"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788631_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR73"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="39046" checksum="DAF4B2209AE1A455" modified="2009-02-10" version="1">MKGWADHSSSEDEDEAPERFNLTVEEIGKPPEEPQERQAQQEAKVHKSRPPKTYVYPTEPPFSAFVGNVAFSIVDPNDLANELVKITKEKLGVDVVIENPRIVMDRHSEKQQHRGFAYVQVQNVDQLKALIQLNDFETVLAGRKIHLDTANGSGHERSRGNNRRGPANDIDGSKFRGGRYNRDRRGNSKDFNHEAGDEVTRDADSNIKSGPPAVRPPLKLQPRSKPLDVANQSTPTNSSIFGGAKANDAGNWRSNRKSEEQSNSRARSNHGASNKTSRDSRRGNTATSAISSSSTQTGPRKQDRKDRDVDRKKAAVVKKSPVAPVPPVQQEPKKEDKVVNKFAVLDFDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRM8</accession>
    <name>B7FRM8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_51345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176567.1">
        <property type="nucleotide sequence ID" value="XM_002176531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRM8"/>
    <dbReference type="FunCoup" id="B7FRM8">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FRM8"/>
    <dbReference type="PaxDb" id="2850-Phatr51345"/>
    <dbReference type="GeneID" id="7196699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51345"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="InParanoid" id="B7FRM8"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="149" mass="17697" checksum="BF08B267B024DD46" modified="2009-02-10" version="1" fragment="single">MVNIRQASVHDLLQMQTTNLWCLPENYQMKYYFYHLLSWPQLLWVAEDFDGKIVGYVLAKMEEDERQPRHGHITSLSVLRTHRKRGIATALMQRSQKEMAEVFESEYVSLHVRKSNRAAFHLYSVTLRYEVNDVEKGYYADGEDAYDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS64</accession>
    <name>B7FS64_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177611.1">
        <property type="nucleotide sequence ID" value="XM_002177575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS64"/>
    <dbReference type="STRING" id="556484.B7FS64"/>
    <dbReference type="PaxDb" id="2850-Phatr43419"/>
    <dbReference type="GeneID" id="7197431"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43419"/>
    <dbReference type="eggNOG" id="ENOG502T0MJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810046_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS64"/>
    <dbReference type="OrthoDB" id="49060at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="343" mass="39105" checksum="36A0DC32BA48A8E4" modified="2009-02-10" version="1">MFPINPNGDATKKGKPRGRKKKPRKWTKPDGMPKRPLSAYNLFFRHERRKLLDASSPSIEDNEETNAIVAESKIGFAVLARTIASKWRDLEENEKIPYVQQAEIEQERYKREVEEWQRLGLDPRQKNPEASNACNAELFIDNQHNLDSYRKPNASFSVQRHTSSHKANISPFNVPQSSRTSNSSTFSLQDLVQSSATPEFWEKEGRADLPSSQNKFATSVESALHQHQPYQFRQLHQEKDFFETVESSSYDQAYAPLQPFAASINKSPKTQKVKDTARGDNLAEGTEAFWSEATKNFALPSQVEDQKLPANDEYQTTHATQASLQQLQEKLSSEEISFLKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSD0</accession>
    <name>B7FSD0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_4936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177642.1">
        <property type="nucleotide sequence ID" value="XM_002177606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSD0"/>
    <dbReference type="STRING" id="556484.B7FSD0"/>
    <dbReference type="PaxDb" id="2850-Phatr4936"/>
    <dbReference type="GeneID" id="7197180"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4936"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_2_0_1"/>
    <dbReference type="InParanoid" id="B7FSD0"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000117">
        <property type="entry name" value="Probable papain cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="256" mass="27928" checksum="D2C279045C2048BA" modified="2009-02-10" version="1" fragment="single">LPDNFSWANVNGVSYLTHSLNQHIPQYCGSCWAHGALSALADRIKIARLGQGDDINLSIQYILNCGGGLAGSCHGGYHTSTYEFIQQVGYVPYDTCMSYLACSEESTEGFCPQLDTSCTPDNTCRTCDTFAGMGGACSRIDYFPNATVAEYGLIDLDDFVVHKIQTELYVRGPVAATINAEPIVEYAGGVFGEDGHSQRTNHIVSITGWGTDEDTGKLYWIVRNSWGQYWGEMGFMRIEAGKNLLGIEGEVAWATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT15</accession>
    <name>B7FT15_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_32929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177759.1">
        <property type="nucleotide sequence ID" value="XM_002177723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT15"/>
    <dbReference type="PaxDb" id="2850-Phatr32929"/>
    <dbReference type="GeneID" id="7197513"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32929"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_1_0_1"/>
    <dbReference type="InParanoid" id="B7FT15"/>
    <dbReference type="OrthoDB" id="44832at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="794" mass="88589" checksum="E6C43B0CB25EB063" modified="2009-02-10" version="1">MYKNSTGVASAPLEEEGNIPPLVAAHVPSYGTGDESEPDPVRVMIDEDVASEEVPLVVTHDDDKDAIPQFRDVPFAVLFLIHATLMVWLGIFVAPKGYSKINIDFDMIEKEMRKGDDMSEQDIADFERFVAFVGKYAQVYPKRILLSFVFPTALLAFVIALFTTIYVVKPCPKTLTYASLVGSFAFTAIVMISSSVLNNSLFGAVMTIVALGAVAYYVCAAWRMVPFAAVNLKVALIGMSRNCGVYLVAFFASELGFLWPIYWVYVLIGVSVDRNDKCEKAHPGANFDMSSNDFDDVCHPPPLVFLLFLLSLYWTSTVLLNTVQVSVAGVMATWCFDKRDADHCCSPAVFGSVYRSMTYSFGSICLGSLLQALISVFRYIVESARSQRERNDGGGACGNILLCILECFAKLLEDVIDYFNQWAYVFVGIYGYSYLESGRRVIELFRARGWTAIINDNLVGYVLGFTTVLIGVLTGATALLLEFTVSRSKLEANSEYESYIFGPIPGWRWWAFGIGFFVGIWVSSVVMNVVKAAVNTLVVCWADSPAVVEMNHPRLTSEMADSWLQLRYRKVWQLKDEKSSICYDADLDDPVSNRHRLVIKTTESSKATTLFSTFHATLHRMANACISGRNTRRYQISCRRFIQLLFLLAAAVSAISGHRQTFVRVHNQPQISSALSWNIEAGSYDEKIALRIASFPRGGSDTDVEGGESDEYDEDREVEEDEYDDESDEGDDDEKVVPIEISIEKYDEPLVASPMINLYASFGVMMLARRIDLFNPIVVRVARQNLPMIGLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT30</accession>
    <name>B7FT30_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Insulysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_18335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177765.1">
        <property type="nucleotide sequence ID" value="XM_002177729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT30"/>
    <dbReference type="STRING" id="556484.B7FT30"/>
    <dbReference type="MEROPS" id="M16.008"/>
    <dbReference type="PaxDb" id="2850-Phatr18335"/>
    <dbReference type="GeneID" id="7197229"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18335"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="InParanoid" id="B7FT30"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000132">
        <property type="entry name" value="Protease of the insulinase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="196"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="392"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="801"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="112286" checksum="DF762B4BE11805FD" modified="2009-02-10" version="1">MATANFLDILKPPLDDREYVAYTLENGLRVLLCSDESSNEAAVAMDVHVGACSDPAEVPGMAHFNEHMLFLGTKKYPKEDSFEAFLASNGGSSNAYTASEDTVYFFDMAAEANAKFAEGLSRFGAFFTAPLFTEGATGRELNAIESENAKNLQSDTFRIFQIDKSRANPDHPYSKFFTGNKKTLLDDTKAKGLSLREELIKFYNNYYSANQMTLAIVAPQSIEDLKNMVTEAFLDIPNRNVDTPESSWAGIPPFIDESSIPSFKNAIEIVPVQDLRQIMISWPIVYSSEDQRQDDLLNKPTTYIAHLLGHEGPRSLLSYLKSRGWANSVGCANSEELSDFEVFEVVVGLTTQGLAQVDEVVESVYAYINMLRDRKIPNYVFEEVFRLEELQWRFLTKGSPRSYASSLSTAMQKYPPELYVAGPRRLAEALERSRKQAELLADNLTVDNALLTVMSKDFDNKTDRKEKWYGTDYRVRPLSVETLSRWRRGIRAEQIKIDFPRPNPFIPTEQGLRRSFESRMMPVPPPSLLRDDGPDGRWKVYFKADDRFGLPKGYIVFQVVTGEAFASPRSAALSNLFEVSIADKIGEYAYDASLAGLTYDVKIMPRGIRLTFGGYNDKLKRFASYISLKLTTEIRDVLPTSESVFDRYKDQVMRGLSAFDVKQPYFHASYYSQIALQPPRFQYDNTALREAIREVNLSDLIEYVNTLWKSGRGEALIQGNFDQKEAMELVKNIGDVLPFRPIVQEEYPSRLEALPLPAYGPKKLPTKLIVAEPNPDNENSVATVMLQSLGTSEKDHVLIELISSIVQEPFYNELRTKKQLGYIVSSGIRAVGNSRTLSFIVQSSVAPADKLSIEIVKFLNTVEDRFLNKLLKADLAVYVKSLIDRKTEPDKELATEVTRNWAEIASGRFQFDRIQREAAALLDVQKEDLLDFWRRIYTGDNCRVLVTQVVPRQGPASSPVPAKSTGYNDKDPLPEGLVLGIDDLDQFRADRQMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTC5</accession>
    <name>B7FTC5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracycline resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177818.1">
        <property type="nucleotide sequence ID" value="XM_002177782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTC5"/>
    <dbReference type="PaxDb" id="2850-Phatr43754"/>
    <dbReference type="GeneID" id="7197271"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43754"/>
    <dbReference type="eggNOG" id="ENOG502SMZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551554_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTC5"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="493" mass="54099" checksum="BF9D50FBDE538DAB" modified="2009-02-10" version="1">MSPYARPLMDRIGSFFYSSEDSTDIDKQRAKQHTPANHDKLGKSHLQKPKFPRSWRRKIPPTVSLPLLVLLDMLAVSLVVPLLFQYYQTAGVTRAHERELLSALFSASQIIGGLLVGALTDAKLVRRKSILFLSFGGSALSYALIVYGGLPALIFSRVLVGLVKHTMTVATTMLSNCTTKDTRAKHMGRLTASSTAAWIVGPSIGALAYQYVDERAPALFACAIFATNMVLAAVLLEGDTFESSHPKNDNPDEQSDHTNVEHDEKKKAVGGNTIFNRLKSCFTSKALSSVVLTQLVVTWVSKATSFSQLGSFYEDMYDLPSYHRGYISSFQQLLHFAAQATLVGPVMQQLGGERRTTCLCTAVLSVAVLFKAQGSLWFFLIALCPVLALCSTMIHLSLQTLVTHVAPSESIFSVLAALDVLQNAVSVSVPFYRTILFRLLSADNSAAMQGDPDPMSWIVTSAMHWAVATVAITYLLLWNEGMRTENIQHKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTK7</accession>
    <name>B7FTK7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="8">DHBP synthase</shortName>
            <ecNumber evidence="8">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_6454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="8"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178168.1">
        <property type="nucleotide sequence ID" value="XM_002178132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTK7"/>
    <dbReference type="STRING" id="556484.B7FTK7"/>
    <dbReference type="PaxDb" id="2850-Phatr6454"/>
    <dbReference type="GeneID" id="7198001"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6454"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407986_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTK7"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000001">
        <property type="entry name" value="Riboflavin biosynthesis protein RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="194" mass="21087" checksum="1925F8BF33B0969E" modified="2009-02-10" version="1" fragment="single">AIASMKRGEMVVVVDDMDRENEGDFIMAADQCTELDMARIVRYSSGVVCIAMEGSRLEELKLPPMVTNNQDPKGTAFSVTVDATKKHGITTGISASDRATTINLLANPSTAAIDFHRPGHIFPLRAQEGGVLARDGHTEAAVDLSRLAGRSPAGVLCEIVSEDNPTEMMRLPEIRRFCKRHGFVLTSIVDIAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTQ7</accession>
    <name>B7FTQ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="7197981"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44327"/>
    <dbReference type="eggNOG" id="ENOG502S0B8">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 1, MITOCHONDRIAL-RELATED"/>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="75"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002178467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTY1"/>
    <dbReference type="PaxDb" id="2850-Phatr44392"/>
    <dbReference type="GeneID" id="7197857"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44392"/>
    <dbReference type="eggNOG" id="ENOG502SPQI">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855003" evidence="1">
        <location>
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            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="254" mass="29661" checksum="F4DE063C4CE6F0B0" modified="2009-02-10" version="1">MKRRLCCLELMRLGFVVSLTGAFMLPELPLNSMRACSICPLSPFANPTAVSARNSNPAHSSTSLNLLLDVPDGFFTITFPTLGILLSLSKNFARIRMEENAWEQRLAEARKERLRKDPTLTEIDLRRKEAAIEWSAYGKPRMEEEQLERDLKEIQRSRTRVMDRSEDEEDVVGTEREYCMTDEEIESFELEYGVEYDSYYDDPYSEEELPEGKFSLDRMYGDRVYDNGEIFYKDKESGLYYRQGAKPRNLSFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUF6</accession>
    <name>B7FUF6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44536</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178586.1">
        <property type="nucleotide sequence ID" value="XM_002178550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUF6"/>
    <dbReference type="PaxDb" id="2850-Phatr44536"/>
    <dbReference type="GeneID" id="7197788"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44536"/>
    <dbReference type="eggNOG" id="ENOG502SRGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502026_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUF6"/>
    <dbReference type="OMA" id="ERWHTTH"/>
    <dbReference type="OrthoDB" id="49032at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59304" checksum="62BA429106CC82B2" modified="2009-02-10" version="1">MRPGPVRDGIEQIVCESGNQPQLVLLSLSSPSTDDVHDGLRPIPVPCVHSHRPLHCSHERLLGEKVGMDAWDKLFSSIKGLPSSAAFETVSSTLSPILDDLDAGYKDDPPRLPLERARVNALTLACDLGQAEVVRWIVDRWEAVSNSARDDPVVLSLLGSPCDASPEEHGGNFPAHHAALAGCVPVLDMLARLLLCTSTQDAARTFVDTKMWARRMDCVRYLGSQTNAHGDTPLMMASVSGHVTFLQEWVYLASEDTEPAVDPCLQKILQVRNASHDSALSLACGHGREDVVQFLLHGDGMKDWESLATFEDVCIARAVLKRLDGIVRSREHEGSDQGLTDLIMKRASIQVCLEWVEASLTRKANNLAAELSLDECRRKNTLPAARKPRSKRRTAKSQVTKDVCVAGASPRSSSIETDEAASVNLTQLADGTRAVVVEGTLEDIPPDVLPMSNETALSKSVNQLLRERWHTTHQDSEIDAVMDALCLDVSMLLLTPHGMALHLSPSQLDAVDRILEKQQLAVQQARCIQDRLHGSGSSVQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUG2</accession>
    <name>B7FUG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malonyl-coa decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_10799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178317.1">
        <property type="nucleotide sequence ID" value="XM_002178281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUG2"/>
    <dbReference type="STRING" id="556484.B7FUG2"/>
    <dbReference type="PaxDb" id="2850-Phatr10799"/>
    <dbReference type="GeneID" id="7197791"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10799"/>
    <dbReference type="eggNOG" id="KOG3018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023433_3_0_1"/>
    <dbReference type="InParanoid" id="B7FUG2"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="36845" checksum="F9A8E4B1F7896F6F" modified="2009-02-10" version="1" fragment="single">HLKQLDTFLRRLLSTWFSPGLLEVQRITYDGTPASIIEQIVRQEAVHPVKNLDDLRTRFGPDRRVYALFHVLLPERPLVVLHTSLQPEIPAYMNQVYNEGSLRSDARVAAFYSISNLQAGLSGVGLGEHLIKTAVHRLQGRIGLDTFVTLSPVPRFRKWLEERVQHVTGKFASNDLVVGEDLAKLSHFLQCREDEAVSRMVETLRQEGPSCLDDNAVEVENLVAPLLRGTLAKLAARYLVTETHRRKPLDGVARFHVGNGAILHRINVNADTSRKGWHNSFGIMVNYRYDLEQLPTNVTQYEAEYRIPLGEDVQALLDESLPPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUT9</accession>
    <name>B7FUT9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_19191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178655.1">
        <property type="nucleotide sequence ID" value="XM_002178619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUT9"/>
    <dbReference type="STRING" id="556484.B7FUT9"/>
    <dbReference type="PaxDb" id="2850-Phatr19191"/>
    <dbReference type="GeneID" id="7198132"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19191"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FUT9"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="32220" checksum="58EC8CEF0DEF67F2" modified="2009-02-10" version="1">MPCLIITGHPSAGKTTLAHLFAERARARNLACLIINEASTSPGRTQAACYATSYDEKKSRGALKAAFDRAVAASRETNTLVILDSLNYIKGFRYELYCISKAVGERHGVIWVLNDVSLVQQWNALRRQSSADSEAFYSDALLQELMQRYEPPDSRNRWDQPLYRVDVRPAELRKTGLALNLLEKSPLLEGMSTKQHAASDANTLNNVDSVSQEICTLISAAQNKSTSAGGKLPIPIYGTTLYFQCARRIPPTEIKRLRRQYILWIAGHPPEDSSERGIAQSFLDYIQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUU7</accession>
    <name>B7FUU7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_44661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178382.1">
        <property type="nucleotide sequence ID" value="XM_002178346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUU7"/>
    <dbReference type="STRING" id="556484.B7FUU7"/>
    <dbReference type="PaxDb" id="2850-Phatr44661"/>
    <dbReference type="GeneID" id="7197649"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44661"/>
    <dbReference type="eggNOG" id="ENOG502SC4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544556_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUU7"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="326"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="501" mass="54932" checksum="40D458D448371868" modified="2009-02-10" version="1">MSLVASNGAVWEYMMLRRRPLPLPGTTVPVVHNSADEEEPRDSASTLKIHGKRQQTPFALRFPTYTSKLSVCVTVSVAGLLYLAFLWCETAQLLKAVTLLPAVVCAVLAIVCPGSQRILPSTIVATTLGAQLPQYIAAALASAALLWFGITTARDAIQIKRFKRTVAPPPTQVVISVLVLAGVMLTENFMIWVVSATFFPGQNPKTEPPPLQDNGQRLFQSLMQGFTKHQVVQLRRVWNVQWGLVSALGASFLVLDRYHPTRQLYAVGTRAIYTLSASRFVRTVSFLLTVVPSQVSGCFAQRFPSPPPTDVWEWIAVGFLPAAHGGCNDLIISGHATVTSTLACVAVSAHPSKVFGGCLVCLLLLDYSVEIYEGFHYSVDMWLGLVIVSLFWKVFSFWEDLPETKPANAPTSDATGFPQPEASLSNRDLAVYFASSTVSYLQVVVFPRSIVNGWIVVFVLSVAVCFVFMLRAKTSAEASTFQYYAQHILLCTLHMAFGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUX1</accession>
    <name>B7FUX1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178394.1">
        <property type="nucleotide sequence ID" value="XM_002178358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUX1"/>
    <dbReference type="PaxDb" id="2850-Phatr34164"/>
    <dbReference type="GeneID" id="7197890"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34164"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="B7FUX1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="133" mass="15117" checksum="4D444F5E4D296367" modified="2009-02-10" version="1" fragment="single">MTRSQTTLAYGTQPLKVNAEHLIQRPAPLRLFPFRPYVVHAAPLEIEIFCREEAVPSSSLASCSSMNYEVYDDDANVIETVSDEELHEEMDTEQQPTEAESNNGNRNSNTRRGNRLSDQVNMDDEPEIPGYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVS1</accession>
    <name>B7FVS1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178753.1">
        <property type="nucleotide sequence ID" value="XM_002178717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVS1"/>
    <dbReference type="STRING" id="556484.B7FVS1"/>
    <dbReference type="PaxDb" id="2850-Phatr44822"/>
    <dbReference type="GeneID" id="7199770"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44822"/>
    <dbReference type="eggNOG" id="ENOG502RDAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272433_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVS1"/>
    <dbReference type="OrthoDB" id="26487at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46566">
        <property type="entry name" value="1-PHOSPHOFRUCTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46566:SF2">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE ISOZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="400" mass="42269" checksum="75BCC01A9AECE670" modified="2009-02-10" version="1">MHLPSLVMTGSSVIVGLNGALQKRFVLPRSTELIPGNVLRAAEVQSGVGGKGQDVAITLSCLQYDANLQVAQFIGMGAEGDTVHKMLSDLLGNDAMKLTVRQDSGMRTCTSIVASGTTTELVEPSGMIQVDEMNELMKKLENLEASALCIMGSMPPGCDEDTYAKIYEKVATPSTLCLIDSMNGLEPLLQRIAATPNHGPTILKLNASELCKLANVKKSNNEAGGVLPDELVRAVLNFLEIAHPAAARALSAIAITDGAHPGYMAVMPVAEEAEFRLFELPVTNLMDKSPRNLSLTLYPIGAGDAVAAGTLAAWKSLTAEKDAPPCVHTDVHYALAGNESPTSRVMLAAFAFGLACGSASCLQEQNSVLKIDDALLLYNKEGRPSFVSSNPILTSSKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVT1</accession>
    <name>B7FVT1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_44831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178986.1">
        <property type="nucleotide sequence ID" value="XM_002178950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVT1"/>
    <dbReference type="STRING" id="556484.B7FVT1"/>
    <dbReference type="PaxDb" id="2850-Phatr44831"/>
    <dbReference type="GeneID" id="7199550"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44831"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372352_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVT1"/>
    <dbReference type="OMA" id="AKWKANI"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC49684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="747" mass="81727" checksum="F499D6BF74FC3E23" modified="2009-02-10" version="1">MGLKDAYLVLYNSACCAGWAYVWYAACTTILDKVANQSPFGDASAQVYAHDDTATMLTYAQSAALLEILHAALGLVRSPVMVTAMQVMSRIVALVALVFSSQAQTQWGAGLMIISWASVEVPRYAFYVTALLTGDATKKTPFPLFWLRYSLFAILYPTGICGELTVFLAASKDQAFVDKFGPLSVTLYSIVLPIVYFFGSPFMIMNMVANRKSAFKKRFAKPPPPARGLCWPVDAKGQRSSTNVNKTIIAAAVGAVNEQKAEAIRSCKAWRFQYVKHLRAMVEEQCQTPESALKIAQAGLDSAYDIFEFVAPDGSATTFREAMAAKNTEQFFTHVIKGEGNKLTKELEIPYKGGILKGDALKKQVQSWADYGTIEPSAGAAIVKCIEHPEWLDISNRYFVLLGAGSAMGPLLVLMALGANVIAVDLDRPNIWKRLIDIARQSSGTITFPMKMDPSKCKNDEEMFAQAGCNLFTDTPMIRDWLMNVYPGKSLTVGCYAYLDGALHVQVSLAMDAICRDLSEKRKNTSLAYLCTPTDLHLIPKEAHDAMKANYKSYSGKLYCMMMNLLSGGKFLRQNSKKPVSGKGGEYYLVNGISVAQGPNYALAKRMQHWRAITARNKGCIVSSNIAPSTSTVSVVHNRTFAWAYEGMPYFEPFEIFAPETSNAVMSALLFYDLNDSGSWATPNTSLGNPNQLFSHGSFHGGVWRCAYEVDSIGESSVLLYFGRVAKPYMVAAGAVAAAGAAYVYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVZ1</accession>
    <name>B7FVZ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_34413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179015.1">
        <property type="nucleotide sequence ID" value="XM_002178979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVZ1"/>
    <dbReference type="STRING" id="556484.B7FVZ1"/>
    <dbReference type="PaxDb" id="2850-Phatr34413"/>
    <dbReference type="GeneID" id="7199581"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34413"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374103_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVZ1"/>
    <dbReference type="OMA" id="FANPYYH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="595" mass="65487" checksum="7F538E7FCE54AF24" modified="2009-02-10" version="1">MTSTSSYSSSSSATHSFDYVIVGAGPSAMGLLLGLLDAAEHQSIGLLSIAIVDHGAFSPHSQPHRIVRDLRHWYRAAHDETSSVTNVYHGTTRSGRVLDVPVGRGRGGTSNVHAGLCLAPTRDDLAAWPAPWDTRLPQALQYVQKTLRRHGCVHDSDTARPRLRDGQGSVVAGDEAINATNVPSLRTILPCLARNNGTHIERCNYYQALVAPLLSRNSSRAPKLHWFDGWQAQRLLFDEKQNIDKSSLRVSGVVCERNGILQILYARREIILCAGAIETPVLLLASGVGQRNDLAAAGIPSTVSEHYRGAVGHNLRDHVLIPRVYVTWPCWKPTLSLNGVEAIWQLAVHQAQFQIVVMDAAVYSDVLPYVVTNVLRGSRAWPVVGCIQSWLLHALRVLLQCVIAYTPMYWLLRSCVTTVGIFHMNPASTGKITVTLARTRSTLTSPPSAEGVQRRNLDIQIELPYLRDPDDVAVARVGWVTCTALVSQLIGGLSLPPNGLVHKRWFERFALATCQPYFHWHGTCAIQRNQQETNWVTDWQLRLRDVGGVRICDASIMASPISVPPGLTLAALGYAFAALLLEDRRQVHEFADSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWK7</accession>
    <name>B7FWK7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179399.1">
        <property type="nucleotide sequence ID" value="XM_002179363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWK7"/>
    <dbReference type="PaxDb" id="2850-Phatr34754"/>
    <dbReference type="GeneID" id="7200324"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34754"/>
    <dbReference type="HOGENOM" id="CLU_1172645_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWK7"/>
    <dbReference type="OrthoDB" id="10523790at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="237" mass="26598" checksum="F16C87D8DA1EFCE2" modified="2009-02-10" version="1">MDHLKVWVESHSRSRDEGAALTSSTTSNGFRPPSLRTSSTYDNDETFNKVALNLLSWHEGLNLSVQETIMAILLSPRERSSFFEGMHIRLSRSAHFSPSTASLVQTIESKFGTELKQIVEEESGEKNLHPFYNRQESSDSLPPTTPRHIRSNSSVDFSEPVSATGSKHTSNRRRFFSETTPGPASFFRAPKVRNLDWKLAETIEQVQSLRLDGTFGLQSRSGRGEYQPPSPLARLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWM4</accession>
    <name>B7FWM4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MsrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_7666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179407.1">
        <property type="nucleotide sequence ID" value="XM_002179371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWM4"/>
    <dbReference type="STRING" id="556484.B7FWM4"/>
    <dbReference type="PaxDb" id="2850-Phatr7666"/>
    <dbReference type="GeneID" id="7200333"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7666"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_1"/>
    <dbReference type="InParanoid" id="B7FWM4"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="14725" checksum="BC738B2D22860F0B" modified="2009-02-10" version="1" fragment="single">TESMWRGLLTREEFRVLRSHGTERPRSHRYDTWYPDTGCFACRACGLPLYAARAKFDSGSGWPSFGTHVQGAVATTVEQSPVMGKRVEIHCARCQSHLGHVFADTNTAKWDRLKTFSERHCVNGISLMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXE1</accession>
    <name>B7FXE1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179321.1">
        <property type="nucleotide sequence ID" value="XM_002179285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXE1"/>
    <dbReference type="STRING" id="556484.B7FXE1"/>
    <dbReference type="PaxDb" id="2850-Phatr45354"/>
    <dbReference type="GeneID" id="7199985"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45354"/>
    <dbReference type="HOGENOM" id="CLU_066293_3_0_1"/>
    <dbReference type="InParanoid" id="B7FXE1"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14546" checksum="6307AB1C00EC1588" modified="2009-02-10" version="1">MEDATAFGSTDESEQPVLIPIHSDGDLPEWAVLELNGELIRPKESPDGKENPTSDCLVGPGQVELGSVQFVDADPVMVMGSHRLKGKVETLKQPFCVLRKDVDSDNDTTSYQVTGIITKKLLFNQYPKTIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXN0</accession>
    <name>B7FXN0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179797.1">
        <property type="nucleotide sequence ID" value="XM_002179761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXN0"/>
    <dbReference type="PaxDb" id="2850-Phatr45426"/>
    <dbReference type="GeneID" id="7200540"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45426"/>
    <dbReference type="HOGENOM" id="CLU_566815_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXN0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="482" mass="53502" checksum="1104EFB66471D070" modified="2009-02-10" version="1">MAGTTCMGQELVGAGVEKNNPGKRKRNENGEPAPVDSNPNDTEFESQAMMLIPSLRSNKARQHAFVAPKIGNYMHTSIASVKASNEMDWHISEDQQSEHSFSNAGSCVATAKATRVNLAGNKTAGIVSDNAQINFLHKVSTVCAMSELKGATTSKRASPIVISTLKHDDPEVGMLTRSIEDNRSLDAAGKESVIDTASVGLPECRKTSLNHFRAEAKTKLRIALLAKKQALEEAREGIVQQQGSERVRRKFQQTLRPINALLKGGNASLLIRNISTSGPAKLVRFSDCTMPDLETDDIDIEKKQLSSALPSSLSSPPLQRRMDLLKRKIELQKRLVEAKDRAKLLEQNQIDASKSVVPSTVNDEMNKPSRLELLERKKNAERKRVRAQTAHLLLKQKHLLEEQDVQIEQTKLSVEDYNNEITTMKAELAASALHVEDLTMRRRVLRELKGKAVAKQIQFRQQLHELRQKINNDGREIAPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXP8</accession>
    <name>B7FXP8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179805.1">
        <property type="nucleotide sequence ID" value="XM_002179769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXP8"/>
    <dbReference type="SMR" id="B7FXP8"/>
    <dbReference type="STRING" id="556484.B7FXP8"/>
    <dbReference type="PaxDb" id="2850-Phatr45443"/>
    <dbReference type="GeneID" id="7200550"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45443"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="InParanoid" id="B7FXP8"/>
    <dbReference type="OMA" id="GWVFDIH"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF51">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855469" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="273" mass="30080" checksum="1649103B3865DEFD" modified="2009-02-10" version="1">MKFATAATVTLLALSTVDALNVKKLFRFGKTSLPKDSSPKPAAKGGYDLDVSELFDGNNKFIADKLAGDPAYFDTLGTVHSPKYLYIGCVDARAPPNMIMGTEAGTMLTVRNIANMVVNNDLAVMSAIQFGINVLKIPNVILCGHYECGGVRASVANVDHAPPLSIWLRNIRDVYRLHAKELDAIKDPEERHRRLVDLNVIEQCVNLFKTGVIQAKRIESYKDGGVAIPQVHPVVFDPKTGEVKKLKVDFDKYMAEINGIYDLYDLENAKVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXR0</accession>
    <name>B7FXR0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179811.1">
        <property type="nucleotide sequence ID" value="XM_002179775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXR0"/>
    <dbReference type="STRING" id="556484.B7FXR0"/>
    <dbReference type="PaxDb" id="2850-Phatr45451"/>
    <dbReference type="GeneID" id="7200556"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45451"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071797_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXR0"/>
    <dbReference type="OMA" id="REARICW"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004328">
        <property type="term" value="F:formamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033388">
        <property type="term" value="P:putrescine biosynthetic process from arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07565">
        <property type="entry name" value="aliphatic_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01243">
        <property type="entry name" value="Formamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022843">
        <property type="entry name" value="Formamidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009803">
        <property type="entry name" value="PRK13287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF15">
        <property type="entry name" value="FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="37703" checksum="FA683DEE44138149" modified="2009-02-10" version="1">MSGCGLGGLNKSASGVVLGMVQLQLPVIVTPGDLAEQTTRICEIVGKARRNMRTMDLVVFPEYSLQGLSMDTRAKFMCHMEGPEVAAFKEACKKHFIWGCFSIMEKNPDGNPYNTGIIIDDKGEVKLYYRKLHPWVPIEPWEPGNIGIPVCDGPNGCKLALIICHDGMFPEMARECAYKGAEIMIRTAGYTAPIKHSWCVTNQANAFCNLMVTASVCMCGSDGSFDSMGQGMICNFDGVPLVEGSGRADEIITAEVRPDLVREARVGWGVENNPYQFGHRGYVAVKGGARDCPYTYMKDMVHGSYALPWESEIVHKDGSLYGFPFPEREYKGEEVSPDVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY10</accession>
    <name>B7FY10_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179657.1">
        <property type="nucleotide sequence ID" value="XM_002179621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY10"/>
    <dbReference type="PaxDb" id="2850-Phatr45536"/>
    <dbReference type="GeneID" id="7200729"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45536"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017424_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY10"/>
    <dbReference type="OMA" id="NCERFRG"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF128">
        <property type="entry name" value="UBIB DOMAIN CONTAINING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="309"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="839" mass="94241" checksum="7082642EB8B2E0A5" modified="2009-02-10" version="1">MDDGTLALRQESKQNMPLLRSIAWVSSSTPFSLCSLIVLFAVSLTLDNTEAFVLPDHIPHPPSSQSLLFASQEIEHSRRTWAQRKSPREKVTLIPVDTKWSGGNKLEKTGHSSRAGSPSRFDQLPSSSTTTIVSSQRRQKTKPMPVTGYDAQSIEVHYDRRPLEVGWRLNSLGIPLLGWYMRLLLDRAMGLDGDENVQRKRGQELREHLIRSKSVALIKSGQAASLRPDLIQNRFWAEELGKLVDAVGSFSDLQAMKIMRNELRDIRPRLDVTRTSWQTASRARRRKGRMNRVEKMVEADDVLNLFEFYNENLAVASASIGQVYKARIRSGPQLEAAIGPEQAAKWGGKVVAIKVQRPDVEASASLDMYLLRRTAMWLSKIRGGDLPKVADCFGMQLFGELDYVREANNCDRFRELYEGWSDIKVPAACSAFTRRRVLVMEWIDGVKGPWDGQRGIDMVRIGLRCSVDQLMTTGLFHADPHRGNMLSTPDGRLALIDFGMMADIDEKDRYGLFGLVIGLQNKDLALVTENLLELGFLKDTTQIDQLIPRLRAALMNATGGSGKASDVNFARLQAELDDISRENVLRFSTPPFFTVIIRSLTILEGVALSVDPAFKLVRGAYPYVLRQLLSPEDQVRMPAALQKLLKRLLTVNGEEREIDWERLRDFLRLAQKAARKYDPSMSEVDDKASLSRQTIELFVQFLTSRAGIFLKKPLVHELAEAIDGMASIGEGNLYRMSRGLLPALPGMNGPVNSRRMDEISMMLNTFEDALVMENNDGGSRARMEAIMELFREVSAALGDERLRQDAGPLLVELQSVIQMVAVEVLEIRGSRAMRSILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY57</accession>
    <name>B7FY57_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear pore complex protein Nup155</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_35311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179681.1">
        <property type="nucleotide sequence ID" value="XM_002179645.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FY57"/>
    <dbReference type="PaxDb" id="2850-Phatr35311"/>
    <dbReference type="GeneID" id="7200364"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35311"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229226_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY57"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="112"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="316"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1849" mass="200254" checksum="DD835ACFAA94F16E" modified="2009-02-10" version="1">MVSSQSNRPPGHVPYAPPQQTLDAYWRDDFRPLHAAGRAVLRALRDDEAAPDADLYRRVASSGSPGAAGYYHAGGGGVPTSPRPTTTSAYAPTHGAVAPPVAALRHLRSVPLSPILRQQLQKTKRGSLMGLLREANLAWMSSDDKLFLWSTRAGANGSSFCSFVTPSGQSIVSVGIAPPKKGVFKSNVQWCLIVTTLDEILLCALARTTETDASGAASFDHGPDRALQLVPTSFTMPTDMVRMLSVVGTPTGRIFLGGEDGCVYEVTYEIGPLSDPQQLPLHDRLELFYDGDLDLPSVVEDHHETAGTSFLARGKRLWFSDDRNHQTTARPRKCRKLNRSSNVSAVANALLPDFLLQGTSALLGGKNATGGGKIVQMVVDAERQCLYTLASNGWIGAFDLAKNDALPLTAAADVAKTARLYLEAVSRGQMLPPSSHQRSVAKISFPGGGSAAQAGVGGMEGARTILKLAEADAPRRARQDTTGGILLPRSIHVITRRESSRLTLVAVTEGGLRLYLSSLSSQVLASGPVDGFGPIRPLAPSTRLTLCHVRAPPPADMKASQDNGAVNLNINGSVAPKIARDKIPRVDASFYSQGVFVVAMEPPLSSNELAGRQVGDQILATCPDAIARLPETNDTNGIRELQALSTVSLSSQSSQQLVAPGGICETFSVPTTSSYGETARNVDAMLPGGLVWDIAPITDETSDLLLMLSRSQTPSDSELDLGIPPTFFPPSKIRADVSTSKEIQQATKGTMVHSNSVASVALTVATTAVWNLMLSRPLRYGITYDTSSPLPSLGKSQGPEYRLSKRNASQGFSATASERSGRYNISPSATSSATSIPRSARLRSWLLQPPVAPLNQFATQHLESGREFVVLNVGGLHFFGFKSLMSSLVSVLMAAGENIVHDSSITSFFSSYGYKEGCAMCLAIAIGSGPTPQETGVSEQLRRRACEAALARAFVPKLVPHADPNLNTSSSIGSMPVSKDALVPPGYDFKPSALSEGLTLLFARLVRPMWHKPGVVITEGRSVKSTWSMGKGTRWTPAKVEVLFDPDGLERIKTPLRNLLVLVRNVFSRAIKTVPGKQQNQDSSMDIDDSEGHHQYLTQALEYQSHLRSGNTLVSAQLSPREAEHLAHLIEEKNIHSLYRLLARTIQLLNLIALLHRVQEMTELREIDWGLLHGLTIAQLVETSEGQDRLENLLNSLVTASVSSKSAFVVPSAQTDRIANLFAEQCYLFFSPGSRFAYMGLRLAAEALSSSQLLSSRRLALTQQAASNFRSAAGHWYSAPLITGRILHQRRQESHSEIANRALQYGSPLAKAAQSLMQLEDVASIVEICLLTAANFKSEVPSTSSSSVLTSSTTGSASSLSWEQHLYHKRRESDQAASAQATSSTSSTFAHGTSVTAKDAIDTCYALVFHHMTVLLNTQPELADRMVSASAAASDRQFLAAFFRQLVDSNHVNTLLRLDSPDLEKWLRERDDPDLLWRYFNVQLKHIEAGQISWDHASNNNLQLSLTERIESLSRALNSFKAALSDGQRPTHSSLSSEDIAQKVKEVSETLDLARIQSRVLRAVDSSKPNFPPEVTSEKYSQLCYTLTPVSDLYNDFTSAIPLWDLCLHILHACRHTEMSTIQKAWTFLICEDVLPCATRDEVAYRFLNSFAADVDLGDGVQLLRGEESMDDGILLFENGDWANLLRQRIVELGRELYGTGADYVFPLDFLMLALEGLASHCSSISSAGWALAVMADAGVPYIAILGSYEVLTESQDQVVVGGDSRHRLRNLEATLDLLQHWATSAQSSGLAASNDVETALSELRRATASGRLRPKIEALKGKLEASSGTANLLDRLSSIEEAFQYMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYK0</accession>
    <name>B7FYK0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Long chain acyl-coa synthetase</fullName>
            <ecNumber evidence="8">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACS1</name>
        <name evidence="8" type="ORF">PHATRDRAFT_20143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179946.1">
        <property type="nucleotide sequence ID" value="XM_002179910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYK0"/>
    <dbReference type="STRING" id="556484.B7FYK0"/>
    <dbReference type="PaxDb" id="2850-Phatr20143"/>
    <dbReference type="GeneID" id="7200471"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20143"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="InParanoid" id="B7FYK0"/>
    <dbReference type="OMA" id="PLFTYFM"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="721" mass="79033" checksum="BCCF8749FF2D6704" modified="2009-02-10" version="1">MKYLLFLPVKILLIAIDLLLTIVTFGWLGIIRKITSADQLRTVPVADDESHRVDPRFRAQLITTPRPGMETLYDITKVAFERFGSRHCMGTRHFLGWRTPKIKEFGPDTTWKTYAQVGQQANQFGAALRSAGVQPAPYSTTLEQVTTPCRIAIFENTCAEWMIAAMGAFTQSVTVTTVYATLGMDAVAEAVVDNIIPVIVCNRKDVSRLAQKCSSMPSLKYIVYTDDLVAPNETIEMPKAPKGVTIVSFDEFCASGDTKAYPPTPPKADSCAVLMYTSGSTGKPKGVIVTHRQIVGACAAGDVALQVVPGGETYLAYLPLAHILELMAEFLMITMGCTLCYADPKSLSATGAYPIGALEQFSPTIMVAVPKIWDTIKKGIEAKVHQASPVAQMLVETGFAWRSFALKHGFDTPLFKALVFKKFAKVVGGQLRLAVSGGGPLNTEVQDFIRAAFGVTFIQGYGLTETCAGLTIQDFTDTRGNIAGVPIASVEVKLESTPDVGDKAGQSYLSTDRRDVEGNPIFGRGEIVVRGSNITCGYYMMAEKSKDEFKEDGWFHTGDIGQFMADGSIRIVDRKKNLVKLKGGEYIALEKMEMTYGNSKFVDAVQGGICCYGDGDMDRPIAIMQLSQPYTTKWAQEKGLKGDWEELKTSKEVYNAVLDDMKKEHAKSDLSHLEKLVAVALLDSPWTPENGCLTAANKLQRRAVIQQFEKEFEDVKKKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYQ1</accession>
    <name>B7FYQ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_35594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180213.1">
        <property type="nucleotide sequence ID" value="XM_002180177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYQ1"/>
    <dbReference type="STRING" id="556484.B7FYQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr35594"/>
    <dbReference type="GeneID" id="7200928"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35594"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_1_1"/>
    <dbReference type="InParanoid" id="B7FYQ1"/>
    <dbReference type="OMA" id="KGYLCEP"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="99"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56091" checksum="41A4EEA914C6FD66" modified="2009-02-10" version="1">MKYTSTRNGSIVTSFEDAICSGYAPDGGLFVPECLPPITTTHLQNWSALTYPELSQTILRLFIAPDEVPEHALQNICTSAFEGFENPAHAVPVIQVGSIFVAELFHGPTFCFKDLGMRTVVNLLSYFSQKRQRSITLLVSTTGDTGPAAVRAVSDIGNPLLTILVHYPEGQISEFQRKQLTTVDSSCVRVATFQGGGDDMDRPIKNLLSQQSYTDSNTLLTGVNSYNIGRPLMQMVHYVWTYLRVLEELGKIPGDPDVKLDIVLPTGAMGNLAGGYMAKKMGLPLGKLNAGVNANDITHRVVQTGEFYKSETMLKTLSDAINIQVPYNFERLLFYLTNGQHDLVRAWMTTMDATNRLNLDREWLTVLQRDFNSARLSDEEMCTTIRSTQEQFGYLVDPHTAIAIGAAQKLGCGLDRVTTVHPTVILATASPCKFEESVTAAITGAGWAAYLQNGFPAAARGITELPERSPIVYLAKAGGTLSSWQAEWEERARAIVADLGAANGYRCVTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYQ2</accession>
    <name>B7FYQ2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180013.1">
        <property type="nucleotide sequence ID" value="XM_002179977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYQ2"/>
    <dbReference type="STRING" id="556484.B7FYQ2"/>
    <dbReference type="PaxDb" id="2850-Phatr35595"/>
    <dbReference type="GeneID" id="7200929"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35595"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061917_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYQ2"/>
    <dbReference type="OMA" id="KLMFRCN"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="379" mass="43817" checksum="711937F82B94F70B" modified="2009-02-10" version="1">MNASALSSSKNTRTWILLAIATASAAATVWIIRKRRRHETAEECRITKKAKNLDFHGDTNQHPGVAGARRTIALPTHMERELYKESRRKRMIPKLAMKKPMYDNIRMCDPDGILLSSISLKKARWYVKKNLASWISDDCIQLNFQPKKGLTRHDQNQQEHRKIYNQNFKINQCVVCGADERYMRHYVVPYVYRSQFPSAYKTHLPHDVVLLCPECHVTVEKASQRRMRNLEQALRQQLSVDPKLTSQPFFVDPRLHKVQSSAFALLRWKHTLPESRVAEYESLLREWWDLSADESLTVDHLERAGAVDDKIVNVQYVPGSDLVIDSLGKDDPERIATFVRGWRRHFQATHRPRFLPTGWNIDSPVVSDVRPSTDLASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYT2</accession>
    <name>B7FYT2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_35625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180033.1">
        <property type="nucleotide sequence ID" value="XM_002179997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYT2"/>
    <dbReference type="FunCoup" id="B7FYT2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYT2"/>
    <dbReference type="PaxDb" id="2850-Phatr35625"/>
    <dbReference type="GeneID" id="7201076"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35625"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052717_1_0_1"/>
    <dbReference type="InParanoid" id="B7FYT2"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852826" evidence="6">
        <location>
            <begin position="22"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="167"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="261"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="36618" checksum="94B32624FC1BE98C" modified="2009-02-10" version="1">MKGSAILPFALLSCLVAQAIASSFGGTTWAPIFAGRSHKAISRRTLTHGSNHRPSPSIQAGLGFLDGADCITQVYPCRSIGNTLLRGALLRIASDLSGGTAFETVKTRVTIFPESPLEALNNIVKEGGVPALWTGSQSRTIEGALVGAVFMLGSVLTKAQVKAFGGGPTMAALAGGLVGGVAQAFVMTPAGMIFTSLNYNRGRKGFENDNAMNVIHRVVDEKGLMGMYSGFRPMALRQATNWASRAGFTEICRSVLGLSQYGLLGELLSGAIGGVGSCWNTPIETIRVITQRDIAAGRPQLTMKEQWDDIVDAQGYPGLFRGVTPRALQAIWQTIFLVVVPNMMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYW6</accession>
    <name>B7FYW6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_12267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="8 10"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180239.1">
        <property type="nucleotide sequence ID" value="XM_002180203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYW6"/>
    <dbReference type="FunCoup" id="B7FYW6">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYW6"/>
    <dbReference type="PaxDb" id="2850-Phatr12267"/>
    <dbReference type="GeneID" id="7201094"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12267"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485294_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYW6"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000008">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="51"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="227" mass="24905" checksum="2DD3DB19DB10684C" modified="2009-02-10" version="1">MASLTEQTWKEKLSTTFESESFAKLAAFLEIERKMGATIYPPKEDIFSALNLCPFDKIKVVIVGQDPYHGPGQGHGLAFSVRRGVKPPPSLQNVFREAIDDVGIATPMHGNLEHWARQGVLLLNTVLTVRRGEANSHAGQGWERVTDAIIHVVNAKSDGVVFLLWGNPAHKKAASVDSANHFIIRSSHPSPLGATKTKSPFLGSRCFSRANDALKKMGKDPIDWNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZJ5</accession>
    <name>B7FZJ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179958.1">
        <property type="nucleotide sequence ID" value="XM_002179922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZJ5"/>
    <dbReference type="PaxDb" id="2850-Phatr45721"/>
    <dbReference type="GeneID" id="7200754"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45721"/>
    <dbReference type="HOGENOM" id="CLU_981641_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZJ5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31544" checksum="C9667B5B4AF809F3" modified="2009-02-10" version="1">MTFTSICTATPHNANDLTEPLLPQGSGVKAPPASAVIGRNGEDDRDPDTTIVESNDSYHKEDTDDPACSCTISMGLDRDKLPHQHQHKYQYKQSHTNSGDVSVVTCQDTTFLLLIFPALIAIQFGIVFWSISNNNATTNSESTSVPKITVALVDHWPVVNATIALFAISTWLYRLTLQECRVTNVVLLLVPEILLNIVLGLVLFGQALWGFTVLLVSLLALCSLVVLHGVYQLFCDTRDVDDVVELRDDEMYHGEQPKVNDKKPESQDEEEDYGYYCRCHAIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZR9</accession>
    <name>B7FZR9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179994.1">
        <property type="nucleotide sequence ID" value="XM_002179958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZR9"/>
    <dbReference type="PaxDb" id="2850-Phatr45772"/>
    <dbReference type="GeneID" id="7200790"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45772"/>
    <dbReference type="eggNOG" id="ENOG502SA6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZR9"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="378" mass="42243" checksum="AB8FB641C90FFA38" modified="2009-02-10" version="1">MGSTGRNWEGLGGPVRVDRANLNDIDPSLDECCQREEESNRKGNALRRTLQRYDVVAEKERRRRQLVNTTNFSGCRCCYDPNSDGGEYLALIELRTSRKQKEEDAEETEHQAMEEKKKDDTVDVASDPSDDEFDYLLDEELPGQGEELKALEDLRRAELEMSIFSREVALSHGYGTHRQMHPTRVLKAAGLAPGTRDPSPAVVLHLVDPDSIASASLDLYLEELAQKEAKGTKFLRSGGRSTLLMDAELATKVLPRLKPEKDMPAMVAIRDGVATNVCPRLQGLTDRDGQVVTRAVFEWLDRCGVLLEHPPLLEAVCRIRPEEEALMDCLTSPKPTPPEEPRFDCGVHECCKTFPHEHIGIQNEQQDGLVISEADVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZT1</accession>
    <name>B7FZT1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180361.1">
        <property type="nucleotide sequence ID" value="XM_002180325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZT1"/>
    <dbReference type="PaxDb" id="2850-Phatr46024"/>
    <dbReference type="GeneID" id="7201399"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46024"/>
    <dbReference type="HOGENOM" id="CLU_543461_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZT1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="489" mass="54515" checksum="DE0EF197082039F3" modified="2009-02-10" version="1">MEEGSSEMHLGGYEIETGKVDVDSPEGFVIPTESWLKYAVPFLAQNQLLMRSDVGSFVVITLPDAVAVLERARSSRRWTFRRAHLCRNRAILPRDNLTASFGSAMVGVEGYRGRWTPFSKEVTRIHLSKSLIGRDLSDVVNFHLTCGVPVLGNSLDWKKKTPTTAAMEPSCQIEDKRRSRVLVAIWDSMSKIPKAALRHVQDCKSIRVSFQPKTGNPSELTMEMRNEIPQVQEAHNDVRAGGAWVPVRDSSENVVQGFDPKQQQQSPHSIPDTVKDMEDANLERCLLQSIKSDTDGTVSKERLIVEAPNRVLVAVTEKETSDWILLQHAGILIPPRTKQPSLTPVEGQILHSSRHPFDLAKKMSREQLGLVSPHTSQLYASREQIQFDVEGILDGTLPSKLQDDTHWKYLGRYRNDADYGGGFTFVYFLKNAVTVKSNSVNTSRLLPDPWSRIPNQISLSTAQVRNALTAGEFGTLASALAISLALQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZW0</accession>
    <name>B7FZW0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_12779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180374.1">
        <property type="nucleotide sequence ID" value="XM_002180338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZW0"/>
    <dbReference type="FunCoup" id="B7FZW0">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZW0"/>
    <dbReference type="PaxDb" id="2850-Phatr12779"/>
    <dbReference type="GeneID" id="7201396"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12779"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1630271_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZW0"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="89" mass="9616" checksum="51818379B1E2F555" modified="2009-02-10" version="1" fragment="single">SSRTFCIGDEDHTLGNAVRHVLIRNNSIGFAGYSVPHPSEPVVQIRVQTVAPAGSRGQQPPTATGALKTACQTLYDQCDIVLERLEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7G015</accession>
    <name>B7G015_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_12732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180396.1">
        <property type="nucleotide sequence ID" value="XM_002180360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G015"/>
    <dbReference type="FunCoup" id="B7G015">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G015"/>
    <dbReference type="PaxDb" id="2850-Phatr12732"/>
    <dbReference type="GeneID" id="7201334"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12732"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_1"/>
    <dbReference type="InParanoid" id="B7G015"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="228" mass="24874" checksum="3020B03115A765DB" modified="2009-02-10" version="1" fragment="single">LILFGPPGAGKGTHGPKIESMLGVPQLSTGDMLREAVADKTDVGKKAEAVMKAGGLVGDDIVVGIIRDRIQHADCKFGFILDGFPRTLQQAQALDAMLAKEGAVVTKVVELDVPDSVLEERICGRWIHKGSGRSYHVKYAPPKTMKKNSKGEPIPESMKDDKSGEALMQRKDDTAQALTKRLQGYHNETVPILEHYRPNGVVRSVNANQGMEGVWKEILQALERPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G017</accession>
    <name>B7G017_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-adenosylmethionine-dependent methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180602.1">
        <property type="nucleotide sequence ID" value="XM_002180566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G017"/>
    <dbReference type="STRING" id="556484.B7G017"/>
    <dbReference type="PaxDb" id="2850-Phatr46093"/>
    <dbReference type="GeneID" id="7201335"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46093"/>
    <dbReference type="eggNOG" id="ENOG502S365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339046_0_0_1"/>
    <dbReference type="InParanoid" id="B7G017"/>
    <dbReference type="OrthoDB" id="40071at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.80">
        <property type="entry name" value="RNA methyltransferase domain (HRMD) like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43042:SF3">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE YWBD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43042">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852870" description="S-adenosylmethionine-dependent methyltransferase domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase" evidence="6">
        <location>
            <begin position="616"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="839" mass="93039" checksum="48FDAE7E421287BF" modified="2009-02-10" version="1">MKRGSRCVQASLLALGFVALSDGFSMASKLPTSRRTFEPFAALRAGTEGGGKRKQITIKELQEKMLKSPSKYSAMGTEPSRKKKATRRTRRRVESPKQQYLYASQRSAKQQAVAPAKKDIGKEEGENENENETVFTVDTRNPLLQAKEFGMVPATQHCDPLVDGLKPRLVGQIRISEEAGSGSFAYLVEKPAGWSILGSQASKSKKTTAKGTVTDTEESMPAVQEQRRRKTKTQVKLVDEDGNIDILEYSEEDILALLTPEELEEMKEDLGTDFQAPARSKRLAADLIMPPKDDDPDSSVRSHIKDEHRDLDEETLSNLRRIEGRKQRASEIATFAEAARPSVITWLKDVKAGEGVPIRGGNFWTAIAGACEVDDSGLVLLCPKANTERIFVEYAEYVTVVGNGGHLVPRSKENRNAASSSNDVIKFEIVSKVRKGRGDDAIQTVRVLIPDKTSTCSSIVELCQKQFQDGIRGDPAGNPFDRRARRRLIHCESMSVSSLVFDETCEVETDMFPDDIAVLADRRNHLEYTTGSFLGRASLQQNEMTNAYREVNGAADGFPGWTVDRYDKWLLVQHDPKEPRGPLPSIHDGNTLGIYYIESSPDRSSMGASTNARARLLEGKPAPEFFPIVENGVKYVVNLDRDLSTGIFLDQRPQRAWLSRNCCVDTQVLNCFAHTGAFSVAAASTGASTVSIDLSKKWLDRLSTHLEANDIEFDERHDAIYGDCFDWLSRLAKRGEKYDIVILDPPSSSVGGRKKKRWSIKNDMDELVALAANLVKKGGLLWTTTNSASTHPIKFARLCQKGLDDAGIENAKLERIQPMPADFQTIGPQPVTNLVWRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G035</accession>
    <name>B7G035_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180610.1">
        <property type="nucleotide sequence ID" value="XM_002180574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G035"/>
    <dbReference type="PaxDb" id="2850-Phatr46110"/>
    <dbReference type="GeneID" id="7201343"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46110"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432454_0_0_1"/>
    <dbReference type="InParanoid" id="B7G035"/>
    <dbReference type="OrthoDB" id="43306at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="6">
        <location>
            <begin position="332"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="718" mass="81683" checksum="7CA5A913E7247943" modified="2009-02-10" version="1">MIRIPYAVSYLACSAPFIGNHSQWEGDPVAAISSAVIYHLKPTKEEGRIRACQRPVGNEVRHPIGKVSSIDVKTPTTFLDRKHTLTSINHARVFATAPTDALPLTDGKLVHLTDSNNPMVLSEAFVSVIKGLEASLQISLNLPTLRSCRWKGTDLTIHNVCDQAGSEQKNQRPKTVVYYNRFSQERIICGRSIPPNTHLQLDELCEEPSRLYAVLPDRTAKGLPPTTVRFNDPQRRKSATEFQPCDVPCFHAGEYRLVSQRTIDGTPWRFVFSMEGPHYFSSLFLDRSAYQIDRYYATTSFQSDVPLPYFSWSEYSIQKPMLDFDQAIPAALFLAQNCDSRNDREGIVRALRTSFRVDSLSSCLHNAEPPAGVDMDNKIQIQRHYLFYLAFENQNEDDYITEKLWSALESGTLPIYFGAPNVLEHVPENSVINVNDFDSIDALAAYLTKVSKDRALYELHHAWRLQPLPGAFHRKYDFTNVHGTCRMCRWAVAKRYGWGWNHANQTIVDVAVPRTICVDERGLLQQPLQESWTLKMNDVDTKLQPPKIRFQQESAKVKDSCNVGRDTATIVVGEKEDVFERLIVEQDGVLDIYLRMRTSVKSVRTSRESALLWQFRTPLQHGNATTFVFQTIEEGHMRLQDSTNRITFLTWPRVNVALASFVDGGDHRVIVQVPILPLLRLRVIVEDVDTFHPGAAALENYFGKTMKADFWNPVETFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G094</accession>
    <name>B7G094_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180638.1">
        <property type="nucleotide sequence ID" value="XM_002180602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G094"/>
    <dbReference type="PaxDb" id="2850-Phatr46163"/>
    <dbReference type="GeneID" id="7201248"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46163"/>
    <dbReference type="eggNOG" id="ENOG502T94H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_9_0_1"/>
    <dbReference type="InParanoid" id="B7G094"/>
    <dbReference type="OMA" id="QDIRYWG"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36439" checksum="5A7B9AAC829917AF" modified="2009-02-10" version="1">MTSIDGCHPSSQVTRRGEECRQRGFGFAVDILKREDANACLSMFERYEERLGGKPLSGDDRFKLHLLLPWVWALVHNERIVQLACRSLNTVDVWCWSSDVNVKERRSDAYFPWHQDSTYAGISPVHTAVTVWLALTPSNEASGCLQCIPNSQGRQLEHVEGHVQDSSNALSKQQEIVDFPDTIHPGQAVSMILEAGQASVHDFWTVHSSRPNTSEHRRVGLALRFVSAHAHKTGCRESATLVSGNGHGLFDEEIAPTEELGQAERQRHKQAMAKEKSNYLLTVKSHYCLGEQPEATAVLFIDLLISGLHADVSNPFRAQQYVNSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0H2</accession>
    <name>B7G0H2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180677.1">
        <property type="nucleotide sequence ID" value="XM_002180641.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr46216"/>
    <dbReference type="GeneID" id="7201287"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46216"/>
    <dbReference type="eggNOG" id="ENOG502STWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512413_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0H2"/>
    <dbReference type="OrthoDB" id="49093at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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            <end position="90"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="532" mass="58437" checksum="9F57C4A7539F0529" modified="2009-02-10" version="1">MPERRLRSTTEIILCYPDSCVSLGRTHETMPFYSDTEGAKSNRSPANRSVTDGSECKEANLLLSLASSHNRDHRASSSAVTPSPMFGNDDRSFISTEKQISSLGSTSGRNFHSSPFELPGRRSFPTNINRSLAQPNSDDDEPSPNRKLKAEVAGILSQSAKKRRKQKIQGESLSDSSYIESEIHPNPSPGQRVISPTFETGRYDDDMTIPPHAMAPYPPHYASIPYPAPYGMMPIYPHGYGPPTAMGFAHPGYAPPYYGLMPPPLPAAHAAAAAAAHYHHQQQLQKRNEASVASRSSPLSRPDSSASSESESVSSASSSPTPCTRIRGESMKCIKIDRPFPGYEYASGRKATPLDTPKMPDFQRLVNFPDFLSKKQSEEDSVGRRPVSNRNSASPPPGKKYCVMCGRLRLCSTTGRSHNSNDAKKEEIAHIIPRQNKGVCTSCDVAVWSVTEVPGLDIKWCKGCKNFLPWEKFGEKGLATKCVRCRDRQKVKYAIKKYGKTKGQKSKNLFLTVGGEDDLLAARHLSCLRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0M7</accession>
    <name>B7G0M7_PHATC</name>
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        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PHATRDRAFT_46265</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Bacillariophyta</taxon>
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            <taxon>Naviculales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002180467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0M7"/>
    <dbReference type="PaxDb" id="2850-Phatr46265"/>
    <dbReference type="GeneID" id="7201212"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46265"/>
    <dbReference type="eggNOG" id="ENOG502T09Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_904524_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0M7"/>
    <dbReference type="OrthoDB" id="45856at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855260" description="RING-type domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="308" mass="34808" checksum="0D7B61ACA8A04C0C" modified="2009-02-10" version="1">MFWLLFWAIALILFVVGPIIIDAQKRRKFLNYFPCFNFVEDETEPRSSPYHGNTSFHYVLSKIQQDEIRESFILENVRSFTMTLDSEKIKVKEENERQNDVADVEQAIPIGKTSPTMSVSKKYALRDNDASSGDDDDDGGDLQIAVTLDDGDGTGFIVIPQPGMCCHEDLPKDMLPQPTRDVRNGCAICLCPYESDDKITWSSNTSCPHVFHHDCIVDWLMASGRKHLKRLRRQEEGADGAAQTDPIERVIHFPKLCPCCRQDFIITDRDEDEKSVLLSPTDSTMGQSQPEASANRLEMDPPTGEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G108</accession>
    <name>B7G108_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_36322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180955.1">
        <property type="nucleotide sequence ID" value="XM_002180919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G108"/>
    <dbReference type="STRING" id="556484.B7G108"/>
    <dbReference type="PaxDb" id="2850-Phatr36322"/>
    <dbReference type="GeneID" id="7201639"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36322"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037815_0_0_1"/>
    <dbReference type="InParanoid" id="B7G108"/>
    <dbReference type="OrthoDB" id="48388at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="466" mass="51854" checksum="7F25532B0A07C02D" modified="2009-02-10" version="1">MRETTDEVLDALVLDSSFFGQAQQSFTTRPIPAFEPSGTGEFGVVSEVVQLCLSEECICDSPLLGGQRNLADVLPQQDQVPTTIALVENSEPYAISVIPTSVGHSRAHSVTFADDTKDAAPQTFESPPATVTVDIAKGDISVYDGHSCCDDEEDLSATRDRMASNTHRKGVARYAIKRLRRNLDKELMVDAAIDLACEAMFLQSISHSNIIRLRGTVGTPGTPQFALMLDRLTCTLEGKIGEWRARQDRSSGFLGRFGRDKNAIAALIAEQFTAALDLARALRHLHGRKIIYRDLKTDNVGFDVRGYVQLFDFGLAKELRSRDLVEKPDGYEATGLTGTRRYMAPEVVRCRVYGLSADVYSYSLVLWQIFALQTPFPSYNANQHYENVVAKGKRPPRIPWLPSQTHAMMEEGWSEDRRQRPGFLQVCQILQVELASRTDNVSTTDRSTHLMDRSARSGRSRVDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G113</accession>
    <name>B7G113_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180770.1">
        <property type="nucleotide sequence ID" value="XM_002180734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G113"/>
    <dbReference type="PaxDb" id="2850-Phatr46382"/>
    <dbReference type="GeneID" id="7201641"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46382"/>
    <dbReference type="eggNOG" id="ENOG502SIHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309842_0_0_1"/>
    <dbReference type="InParanoid" id="B7G113"/>
    <dbReference type="OrthoDB" id="40803at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="928" mass="102753" checksum="487D92740962EF4C" modified="2009-02-10" version="1">MERNSDMDALVNSHIQRTRGTVRNRGEHGVLCRPSYLFMTVLLLVVFVATFLTESIEININLKKVDGSGDSKPESSEAKKATSPSSKPSPSSKPSTTGEDANSYENEVASGKFSIPNVEDDPANADNSNVERDVDNISDSTVPGGGSTSEEVPVSPSHVDEAVVPETLVQDTVIDNLESISNNRTPVSTGDAPSKSPTFGAEDLPPGFKKHPSAISDVYVRRGKPLDDAEKAKLADTWGSWTFVDQNANNRPSADFYADYPHRDIPFDKIPETSWQKDPAYLASFLPEAQALVERAMEAILAEYGHSKFDEPQMDFEKRSDMFSLTMLDLEKGEKFPKTASNAGCTTKRSFDGLVRRILHAIMSEDTFNFVMGGHSSAAGHGNHFQQSYTLQFQKVMEPIFARLGVKLTSRNIGMGGLGTLHNSLGAGSIYGSELDILMWDSGMTERGAPIVDLFSIQGMIGGSRVPFIIAEGSLAELHTHAGADVGKLGTGMRGIQKTDSVKTLEQIPWAARYMDCSPEMRTECGNNKYRGTCWIHRPDFNPKLAQKAVPGGRANWHPGDRSHQLEGRVLAFLVLRAIKQALDLWASAENYRLPDEYWHVAGYYQSIRSKLISLNPAIGGCHQNEGIIQRACSTAMKSRTEFTPRNNPSETSIRSILKGNYDFKILPNVYDPPDVFVPDLSVPDGVFEYLAVVENGEDFQPELSRVQRFSSTRRLKSTHHRSLANPSITPGKGWFFTGNSAPDNCDGTYDSFCGRSQDNPCLLYGHNDGRSGLLFDSLSGWLIMDLVELKEGIIILKIEDWHGAKSNKATEGWRCENGSAECSGRRLSSAIRRGNYTSTQLDRNLKAKPPEYCEKFVFEYAIDGKVTQMKKDEFMKKMIQAQRVVQLWVLLDDPNFSSGDPKDVELAFRITGCGREKTMHLTHVYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G142</accession>
    <name>B7G142_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180786.1">
        <property type="nucleotide sequence ID" value="XM_002180750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G142"/>
    <dbReference type="PaxDb" id="2850-Phatr46409"/>
    <dbReference type="GeneID" id="7201657"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46409"/>
    <dbReference type="eggNOG" id="ENOG502SQQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724544_0_0_1"/>
    <dbReference type="InParanoid" id="B7G142"/>
    <dbReference type="OMA" id="CECILRT"/>
    <dbReference type="OrthoDB" id="47859at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="382" mass="43899" checksum="9EC857E49E036A75" modified="2009-02-10" version="1">MRNRRARSIDDGAAVASFDVDGASPVEKRRRPHRNDRSQISTPLKVLRMLQVCFVVGLIGAMLGRHYELWGVVSDEYDPGSAAGDAEADSAANDICTGYLGQYLDPYSAPVEKKKVQTIHLIGERHQGTKWITAILEQCFDNSVSVVPAFGDRHKHWFMLNETAEHGVIVAVFRNIYSWVHSMNYVRPHHAPAHFNIEWREFVTRPWTLRGHANFTTTFPGSASLRDTTPCWQRFLPNEIEPCLESERLVMVNYSHFDSPEVQYVPELSAYELRNDGSGEPYGSIVEMRADKIRNFWSLRDLVHSFYPVQYEYMMHNGLETLVAELESALHLRRSHRCLLDTPRPPKVKHYPTGYVDWMRQHVDWDAEALIGYHRDDVNSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1R1</accession>
    <name>B7G1R1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_36575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181078.1">
        <property type="nucleotide sequence ID" value="XM_002181042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1R1"/>
    <dbReference type="STRING" id="556484.B7G1R1"/>
    <dbReference type="PaxDb" id="2850-Phatr36575"/>
    <dbReference type="GeneID" id="7201719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36575"/>
    <dbReference type="eggNOG" id="ENOG502SGB3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444455_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1R1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="134" mass="15341" checksum="A7AE5FD19E252446" modified="2009-02-10" version="1" fragment="single">MAWHFRLLDTAQQGLAVPFSSYSFDPEELGELWKPMKVPSNWMMQGYDKPIYTNMKYPWPCQPPLVPHENPTGVYRLFFDLPDAIHGGNDDEDDTHWKNVLLNDYSLLLHGVESCCQVVLNGAIVGFSKDSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B6</accession>
    <name>B7G2B6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein SA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181180.1">
        <property type="nucleotide sequence ID" value="XM_002181144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B6"/>
    <dbReference type="STRING" id="556484.B7G2B6"/>
    <dbReference type="PaxDb" id="2850-Phatr13682"/>
    <dbReference type="GeneID" id="7202152"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13682"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="B7G2B6"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000017">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24932" checksum="933DA60D816BA128" modified="2009-02-10" version="1" fragment="single">MSAFASLPEILQPKEEDIQMMLSAGVHTGTRNSDSNMQEYIWRRRNDGVHILNIGKTWEKLVLAARVIVAIENPEDVIAISARPYGMRAVLKFANYTGAQAVAGRWTPGTFTNQITKQFKEPRLLIITDPRTDSQAVKEASYVNIPVIAFCDSDSPLQYVDVAIPANNKGKYSIGLLYWLLAREVLRLRGSISRNEWEVPVDLFFHRDPEELKKNEEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2F6</accession>
    <name>B7G2F6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181200.1">
        <property type="nucleotide sequence ID" value="XM_002181164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2F6"/>
    <dbReference type="PaxDb" id="2850-Phatr47097"/>
    <dbReference type="GeneID" id="7202172"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47097"/>
    <dbReference type="eggNOG" id="ENOG502SNUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971335_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2F6"/>
    <dbReference type="OMA" id="KSSHHEN"/>
    <dbReference type="OrthoDB" id="40160at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855749" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="117"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="287" mass="31498" checksum="EAAE0FAE7FF94BC2" modified="2009-02-10" version="1">MVSMKASLAFLWLLLASNRFCVQSFRPDWSNHQTRLSGSCVFSAKNIDRPNTTDNKAMAFLRRMGRVGGNRDFTHAIGIDEGPSTKSTGSGKKKKKAAFQSCALTGVIDDLSEPFPTTSSGTQWAGYTDQVMGGVSTGHLCREDFDGRTSNVLRGKVSLRNNGGFIQMATNLAHDAKDSRLVDASSFDGIEVDVQYQGEQEEETFNIHLKNVCCPLPYSSYRARFSVPKGSWMTARVPWTDFRGHGPGASDIPFSSNSLTRAGIVAIGKEMEVLLAVSGLRFYREKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E9</accession>
    <name>B7G3E9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181775.1">
        <property type="nucleotide sequence ID" value="XM_002181739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E9"/>
    <dbReference type="PaxDb" id="2850-Phatr37667"/>
    <dbReference type="GeneID" id="7202471"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37667"/>
    <dbReference type="eggNOG" id="ENOG502QYGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_1"/>
    <dbReference type="InParanoid" id="B7G3E9"/>
    <dbReference type="OMA" id="REETYES"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="365" mass="40846" checksum="EA3DDB907BF7083F" modified="2009-02-10" version="1">MDDVLRTSSIRLLQVGEALGIRNLDPESGKIFVTGGVGVIGHRVALRLLRAGYPDVRLGAHHASSLEEENKMGAEIADFAWDREETYESALKGVKSVLCTVAYTKEWQKHFPVFLKACEKAQVRHFVKLSFYHARIAGDPFQEIPLVKAHGDCDELLIESLSPTIESFGHGDMDVAVDFAKPHMSYTILYASHFMSNAFTMQGKELHNSANLATFFGASGNRGVNYVSPNDIAEVAVRVLLEPRQYYNKELTLTGPQAITDQQVADLISKHLNKPVMYVDQPLREFKTEICMSGDPEWMVQDLVCLEKIKATGTEDSLSFVTHDVEKVCGHEAESFEDYLRETDYMTVVERGAEPELKPLKPTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G444</accession>
    <name>B7G444_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_5811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181852.1">
        <property type="nucleotide sequence ID" value="XM_002181816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G444"/>
    <dbReference type="STRING" id="556484.B7G444"/>
    <dbReference type="PaxDb" id="2850-Phatr5811"/>
    <dbReference type="GeneID" id="7202632"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5811"/>
    <dbReference type="eggNOG" id="ENOG502QR7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693438_0_0_1"/>
    <dbReference type="InParanoid" id="B7G444"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22320" checksum="7B21A70D6F020AC8" modified="2009-02-10" version="1" fragment="single">SLASSTSAAAVGADVSSRPVLRGVVFDMDGTLTVPNLDFAAMYRRCGVDPQLDILAELATRPPAQAQAAYAVIEEMEQQGRDTLQLMPGARELAVWLAAHQIPTALVTRNTRRTVDVLDRLLQTAAPTLTLDVVISRDDERYPPKPDPAALYAIAERWQTSPTNLVMVGDSPANDIGFGRAANAVTALLDTGRRYHEQQSSESHATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4J0</accession>
    <name>B7G4J0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182080.1">
        <property type="nucleotide sequence ID" value="XM_002182044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4J0"/>
    <dbReference type="PaxDb" id="2850-Phatr37958"/>
    <dbReference type="GeneID" id="7202696"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37958"/>
    <dbReference type="eggNOG" id="ENOG502SYGW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1605916_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4J0"/>
    <dbReference type="OrthoDB" id="48430at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="210" mass="24412" checksum="BFFA264F0426D8E9" modified="2009-02-10" version="1">MCDRYSAKQEKWERVERHEPTLAFARQRSTRRHRRRIAVDLILIMGLSFQNYASAFLPADFCQVHRRVGLNMAESVDDIGRLQERARVILEKSKAKLANEPIKSELEATGNALPFFASQDRGKMKRNEVIKSKNDEGLITTDGEKMAELSEKEEWEVRGLLDVFESEIKSSDGLKERDVAASIYNLRKTLQNEDYRRIFDKRNRFIGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4M3</accession>
    <name>B7G4M3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diacylglycerol kinase</fullName>
            <shortName evidence="9">DAG kinase</shortName>
            <ecNumber evidence="9">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_14202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="9"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182098.1">
        <property type="nucleotide sequence ID" value="XM_002182062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4M3"/>
    <dbReference type="STRING" id="556484.B7G4M3"/>
    <dbReference type="PaxDb" id="2850-Phatr14202"/>
    <dbReference type="GeneID" id="7202893"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14202"/>
    <dbReference type="eggNOG" id="KOG1169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G4M3"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-NAD_kinase_N"/>
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        <property type="entry name" value="DGK"/>
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        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
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    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DAGKc" evidence="10">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="34695" checksum="95EF52EC2C01B1BB" modified="2009-02-10" version="1" fragment="single">DFSKWTPLLVFVNSRAGPQQGHLLITQLRRLLNPIQIWDLANGGPDPVLDSFCAFTRLRILVCGGDGTVAWIISALEGLNLQRKWPPIAILPLGTGNDLARIHGWGGGYNNESLITILEQISESYVSLLDRWEVTIEDVSKKKKETKSFFNYLGVGADAQAALQVHYLRESRPEWFFSRLVNKAWYGVFGAEDILKATSVNVRKDITLIADGVEVLLPPDSQGIIVMNIDSYAGGVPLWSHGFKADSCQDGILEIVSIRGAFHLGQIKVGLSNAQRLCQCREATIQIRQKMAVQVDGEPWRQSACTLRVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4V6</accession>
    <name>B7G4V6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182139.1">
        <property type="nucleotide sequence ID" value="XM_002182103.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr38073"/>
    <dbReference type="GeneID" id="7202753"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38073"/>
    <dbReference type="eggNOG" id="ENOG502RW39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884170_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4V6"/>
    <dbReference type="OMA" id="CTEINQY"/>
    <dbReference type="OrthoDB" id="45756at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36209" checksum="F551C2CE76998D79" modified="2009-02-10" version="1">MSTSSVTQAKSVRFGKVHVREFLRMLGPSVVPGDGGWPLGISFDLVNEGEAEVSVDSFESRKQERLRNRWRSQYPDSEPPLLLESRQWDYKQSSKNPIFRLIYEKERMSLLLEDTGTTCKGDRSQSSLSHDFEQKSSKNTLRTRSGSFSEQYNDIYTQVKVHHIRNELEQLRNSRSGEGSTGCTCRKLHVYLPPPNAGRKAAHRRTKPAKVKEELRKRHALPEGTVSREELERRLHDLVEEEPCCTSDCPCVRAGIVCQIDSCSCWMISHQMDKGKQFVRNPTTEQIQQRCGNRYGMTTIDCTEINQYRKKFVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4W2</accession>
    <name>B7G4W2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182143.1">
        <property type="nucleotide sequence ID" value="XM_002182107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4W2"/>
    <dbReference type="STRING" id="556484.B7G4W2"/>
    <dbReference type="PaxDb" id="2850-Phatr47781"/>
    <dbReference type="GeneID" id="7203033"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47781"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032959_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4W2"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
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            <begin position="42"/>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46084.1"/>
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        <property type="nucleotide sequence ID" value="XM_002182147.1"/>
    </dbReference>
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    <dbReference type="InParanoid" id="B7G546"/>
    <dbReference type="OMA" id="NDEHSEM"/>
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        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="116"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="26048" checksum="5BE984AA048BEC8E" modified="2009-02-10" version="1">MSGERWGDSTSEDELDLRITEPVHTGLNDGTISTQSLLDPIPQGAKVTVPPSRYSAEAEEDDGNDEHSEMEEEEESSDDEEDPKERERRLVAARELAQQKKEEKKKKQESLNDQLDDLDDILNELGIEAKVVEEESGVDATTEDVAVSSGANSKRRKKKKKKGEGSAPASAEQQEETKVEEAAAADISTVLKAKAKRKSSKSASSTSAAVAAAKETSEAKKGLEVKKKKKKKDLHFPR</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182215.1">
        <property type="nucleotide sequence ID" value="XM_002182179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5B1"/>
    <dbReference type="PaxDb" id="2850-Phatr47902"/>
    <dbReference type="GeneID" id="7203109"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47902"/>
    <dbReference type="HOGENOM" id="CLU_1386574_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5B1"/>
    <dbReference type="OrthoDB" id="10627920at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="197" mass="21942" checksum="80F4F796677AF11D" modified="2009-02-10" version="1">MLDALGSDSRLDMKKDQDQREEIPGSTPVPSSLLSTSAEQASIDTIAGSLDFDLSNHVRVSRPILRVLTQEESLQLCHLKHSSMISSARPPHHVKFDTVEIRAYPIILGCNPAVTKGPPLTINWDHCCGVIEPVDEYEAKRLPRKSAILLRKSSLERQSLLKEEGFGSDDFRMAEAAVDEIKNRESFPSMESLTYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5D4</accession>
    <name>B7G5D4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182228.1">
        <property type="nucleotide sequence ID" value="XM_002182192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5D4"/>
    <dbReference type="PaxDb" id="2850-Phatr47925"/>
    <dbReference type="GeneID" id="7203179"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47925"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485290_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5D4"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
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    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="562" mass="62661" checksum="A6AA394F7DA907B1" modified="2009-02-10" version="1">MGKKRQSRPRLDPGAHIAIIGSGLAGLSTALSLEQGGFTNVHIYERDGSHDARKEGYGLTLTYNPTGVLHQLNVLEEIAQSDCPSRSHYMFNANGEIQGYFGNAFARNRGWGQRGNLRVPRQRVRQILASRLKITETHWDHKLVGVSGCENGENICLAFQLEGAAEEKLLVGADLVVAADGIRSAVLQHAYPQAPPIQSLGIRLILGISSSFTHVHLKERGFYTLDSGKRLFVMPFARTAEWAVIDDNATSCSQPTGEQYMWQLSFASSDDKTYSSTELLQQALFHCRDWHEPVQELMLSTSQESIWGTLLYDRNPEILHKHLQINDTLPRRILIVGDACHAMSPFKGQGANQALQDGRVLVKHLTSARVEIAVSNTQREIVQRTASVVAASRQASVYWHEPQLVMPKDGQDTQKFAGVCSQDIPALLHALQKKNIKANSANDLDKSVQCTIDELQLIGPPEVRRKAESELKEAHFVDLARQAILSSEMNNLAFLRKLSWEYPNLIRNVDVDDMTCLQKAAKSGHIRIAHWLITEAGCLVDARLLNDLSIKSYMKALLKMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5E2</accession>
    <name>B7G5E2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_54818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182399.1">
        <property type="nucleotide sequence ID" value="XM_002182363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5E2"/>
    <dbReference type="STRING" id="556484.B7G5E2"/>
    <dbReference type="PaxDb" id="2850-Phatr54818"/>
    <dbReference type="GeneID" id="7203183"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54818"/>
    <dbReference type="HOGENOM" id="CLU_607608_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5E2"/>
    <dbReference type="OrthoDB" id="48387at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="9">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="451" mass="50623" checksum="5E274AA3DA903698" modified="2009-02-10" version="1">MASTKKNLLSRPRKKPIILSLYGLLAKSAIASSTITDGYSVQLRPDLWLHWIVSVERDELRTVLEYDGEAWIGLGLSKFGKMVGSTAIVGLPDQNEVTYNHVEHQKDVSGLRRESANVLHNLSLIQSDGETALSFTWKLLPTSSIREGGPVTFIYAVGANNELGYHRHRGAFTIDLQNCDEQLPKLQIPSIDKEHKLAFALHGFFASLALGIAVPVAVASAWLRKLIPRQWMYLHVSGQMIAFIFLCISLASVVSGIVLKKSSHFRHGHHWTGIFLLSIFAFQGINGFRRPPLHQVAKMTDNLHAIHGNLDGADDVVNVAAWWLVTLPRTNREKWLLMHRALAVFVISLGIIQLRSGILLYSREYENAAIDLLIVFRGYCIFLVFVAVSLYATQYVNLQKNTIGYDGRIASAWRRDQFPQTTANCRFDTKDECLDGEQSLMETSVMRINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Z1</accession>
    <name>B7G5Z1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_54855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182485.1">
        <property type="nucleotide sequence ID" value="XM_002182449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Z1"/>
    <dbReference type="STRING" id="556484.B7G5Z1"/>
    <dbReference type="PaxDb" id="2850-Phatr54855"/>
    <dbReference type="GeneID" id="7203264"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54855"/>
    <dbReference type="eggNOG" id="ENOG502RRCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087769_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5Z1"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15861">
        <property type="entry name" value="SNARE_SNAP25N_23N_29N_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044766">
        <property type="entry name" value="NPSN/SNAP25-like_N_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF79">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="259" mass="28962" checksum="62D898AFE0A2A5E8" modified="2009-02-10" version="1">MADIQYWDDTLTEEIENVQSMLDHISKMNGHNPMERQSAIDRAKARLRSATGTKRSFKMECRLVQDVNGRRKYEKRLASLDQTLKMLSADLKALESEQARGELFVSADYDDDNPFKRQEMDGAQAGDSMLKEASGIQDKTQESLMNTRNRITESKEVGISTLEELERQRDVINSIEKETDRIDDNLARAEVLLKQFGKRMASDHFIQCFALINCLLLLGVVLYAVIKGGGLGLGNSGTPASPVDGDSGTARLLFLRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6C3</accession>
    <name>B7G6C3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_5465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182701.1">
        <property type="nucleotide sequence ID" value="XM_002182665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6C3"/>
    <dbReference type="STRING" id="556484.B7G6C3"/>
    <dbReference type="PaxDb" id="2850-Phatr5465"/>
    <dbReference type="GeneID" id="7203523"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5465"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G6C3"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="234" mass="26792" checksum="231F0D91916810EE" modified="2009-02-10" version="1" fragment="single">CPHYDRKCTMIAPCCGAAFGCRICHDDYTHHAIDRFAVQEVICRECFTRQSSRTNHCINCSVQFGAYHCNICNLWMSDEERPYHCEDCGFCRVGGAESFLHCHDCGMCIDKNLYDNHNCKSGKYKSNCPVCQEYLFSSRSASHEMPCGHAIHWDCFRQLAAHDSRCPVCKKTAETRERMMPTWSCMASNIAMQPIPPELSRVVNITCNDCEQRQDARAWHFLGIQCHTCSSFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6V0</accession>
    <name>B7G6V0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182794.1">
        <property type="nucleotide sequence ID" value="XM_002182758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6V0"/>
    <dbReference type="PaxDb" id="2850-Phatr48356"/>
    <dbReference type="GeneID" id="7203629"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48356"/>
    <dbReference type="HOGENOM" id="CLU_420087_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6V0"/>
    <dbReference type="OrthoDB" id="47065at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855492" description="DUF11 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71122" checksum="F8E49DA34F19BDD0" modified="2009-02-10" version="1">MKFYRAIASFQMALLGTASVAVAQQLKPRPMQTYFVPLPETDIFYETFDRINAIATAPVMSIISVSISTDNTIVWYDEWEDDYDQSVDQPGSTTKIWGDGIASNGCAPGVTPCTNTNDRLRAGQAIILENWVDLPRNNKQIRFDGGDRIQASFPIAVTRAQYPKEPGSLLAGAAEVFDTMRWGREFVAPVGQDIRGANYRDAFEYTALYMMAEEDDTIVTLPDGSKIFLDMGKSHLVRVNMGAKISADHNIQVHVLAGDIGSTYEMRWFALVPAAIWSSEYITPVGDSTAETKVVCYNGGTSSITVDYQYFTGTTLQRKTMTLAPNTVGQSLFIPTNSGARFNSTGKFIALSTSDTLSSTSGQIYDWGFPVMPRSQLSSQVLIGWGYGCTGKVCVGGQGSRSVVWITPTANADLYIDYNNDGVVDSQVAANYLSSTRITDTDNDMTGAMIWATVRNTGPFGTAVDIAAAWGQDGSHGVVNPGDTLLYTIRIQNLGQVDVNINGLTIINNGVPPLTTYIPNSVWYKPDGGAAPIKVPDKTTGTPNPLDAEGIPNPVKLTKRGGTHEIVFAVTTQGTVDRIIPNNGFIVQSDNRPNLPFAVDIPLVVPTAQPKVANNNNGTVCIPLTARREVRRQLREEGRRERRRLAEEAIYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6X4</accession>
    <name>B7G6X4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_48376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182806.1">
        <property type="nucleotide sequence ID" value="XM_002182770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6X4"/>
    <dbReference type="STRING" id="556484.B7G6X4"/>
    <dbReference type="PaxDb" id="2850-Phatr48376"/>
    <dbReference type="GeneID" id="7203641"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48376"/>
    <dbReference type="eggNOG" id="ENOG502QYP6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720545_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6X4"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="43055" checksum="95FEE3172D7878E1" modified="2009-02-10" version="1">MEAASTSSNSSDGEDEDSTTAPARLAVAEARTRTNRNRPTGSSRTASNSSSSESDSDSEAPRRFPDLASSSEDEQLGEEDSSVEERNSNDKFAQAESDCEEESEEGDIVEDVPLAQRIEKQREQTIDLTQRRKRKSEALKIATRRLADLKKAKRVKDEHGKEAPQSEVKRSKHAPTEASSKRSDFYNRHGPQLNESGIGVEIGAHRYKPRDPRISSLSGRLNVEHFEHNYEFLQEIREKEIALLKQKITARKTSGRKGHTMRQRLGITQEQGGGSGDLLEEDQAELKRLQHEKAAMERQQIDRAAKRSVKKKLQQQVEEGQRRGPFFMKRRELKKLHVEAKFDELRKRGGDQAVQKAVAKRRKKNKSRDAGLLGGRDGNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7L9</accession>
    <name>B7G7L9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC45385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF41">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY (PH) AND LIPID-BINDING START DOMAINS-CONTAINING PROTEIN"/>
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    </dbReference>
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            <begin position="752"/>
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        </location>
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            <begin position="310"/>
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        </location>
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        </location>
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            <begin position="315"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183210.1">
        <property type="nucleotide sequence ID" value="XM_002183174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7V0"/>
    <dbReference type="PaxDb" id="2850-Phatr39109"/>
    <dbReference type="GeneID" id="7194818"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39109"/>
    <dbReference type="HOGENOM" id="CLU_1463979_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7V0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="20693" checksum="F995F960695D1C16" modified="2009-02-10" version="1">MNKRRQSLVGRAKDPISFGLRLKFIDLPLSHAADDEADSAQPETVPWPCLAFTSIHELLGILSVENDGDYISCTRRQHRLTVELLRHIYERGGSYTDPVYFLFGSRTPGGNRLFFADVNNCCFRGRRLVANDYRSHITTAVDCMEQEAAFLDALNETAPILTNLLAEEALRQDYLPGPGEHAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7W6</accession>
    <name>B7G7W6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39127</name>
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            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183218.1">
        <property type="nucleotide sequence ID" value="XM_002183182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7W6"/>
    <dbReference type="PaxDb" id="2850-Phatr39127"/>
    <dbReference type="GeneID" id="7194826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39127"/>
    <dbReference type="HOGENOM" id="CLU_938328_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7W6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33514" checksum="4BC4514DC8F96152" modified="2009-02-10" version="1">MAKAVAPSATTLRWRSRVTKVAASSVDEDEEDDVRVGSNMTHNHNNSAIFGTLESKTSRTSVSANRALIWTALAALAVGCNIYNLRLLHTWFVTITCALNVVCALLSVWQRQRLRRLGNLRSIHNKARMRVQQMHSQNERLYRHLTSLDRSVDRLQAVQASLDQIVGEQRGQEDWNRLGRVVTEYRDTQDGIKMRLQQQAQERILRVVLQTDSNANFELSGQETERLVLQLSNLPGLSLHELQLREVIANSDKSLSTIVRLLKQVVEDGKDPDHASVFEFDARSAVSESHDANLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8F9</accession>
    <name>B7G8F9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_22739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183461.1">
        <property type="nucleotide sequence ID" value="XM_002183425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8F9"/>
    <dbReference type="SMR" id="B7G8F9"/>
    <dbReference type="PaxDb" id="2850-Phatr22739"/>
    <dbReference type="GeneID" id="7195070"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22739"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_1_3_1"/>
    <dbReference type="InParanoid" id="B7G8F9"/>
    <dbReference type="OMA" id="VQNCSKN"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="396" mass="42491" checksum="BD38A4EE74BDC09D" modified="2009-02-10" version="1">MAMEKRNNSARRAVETKSSIDGIEEGLAMEERESLVEGSSPASGDRTHIGANQTNPDTAHSTVDAGDKKKEVPAGVITSTALMVLILLAVQNCSKNLLMRYVMKDQPKFLTSAAVLGSEFTKLSLSVGYILFVQHRSPQTIFRYLKEDMRNTMLLAVPASAYNLQMSLEYVALANLNAAAFSVLVQTKLIFTASFAAAVLRKRLRYAQVISLVLLTAGVMLCNYKGGSVDVDTNGNSTKGILATLGIALSSGFASVYTEKVIKGQGSTKRSVNIEDYGLAYTQVQLALMSLLTIGVYAIASDFAAIVRDGLFYNFTSAAFASVLMSALGGLIVASVLKYADSVLKGYATAMSVILTGLLSMVLFGTTLSVIYFMGIINVVMAVLLYNAKDLDRFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8H9</accession>
    <name>B7G8H9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183472.1">
        <property type="nucleotide sequence ID" value="XM_002183436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8H9"/>
    <dbReference type="STRING" id="556484.B7G8H9"/>
    <dbReference type="PaxDb" id="2850-Phatr48822"/>
    <dbReference type="GeneID" id="7195124"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48822"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_1_1"/>
    <dbReference type="InParanoid" id="B7G8H9"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="4">
        <location>
            <begin position="169"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="256" mass="28318" checksum="45B66E363D227CAF" modified="2009-02-10" version="1">MSGSANGYTRNKHCLANRVTRCVSEGLFSPQFPLFCFLQFDVSSDKGAAAFNGFMGSKSYIEGWSFSPADSEMFAKFESVPDAAKFPHSYRWYIHVAALQGVRGLNLSPPAPAAAAAPAAAKADAEDEFDVFGDDDEEDDEPKESRADMLARLKKEAEERTAKKEANQRTLVAIEIKPWDVEQDLMVLWKKITETIVQDGLKWGESCNLADVAYGIKKIQCTFVMGVNNSSDDVVEKILEMEDEVQSCEVTSMNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8I6</accession>
    <name>B7G8I6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183475.1">
        <property type="nucleotide sequence ID" value="XM_002183439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8I6"/>
    <dbReference type="PaxDb" id="2850-Phatr39390"/>
    <dbReference type="GeneID" id="7195083"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39390"/>
    <dbReference type="HOGENOM" id="CLU_010444_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8I6"/>
    <dbReference type="OrthoDB" id="41786at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34310" checksum="D3170973F3C161BC" modified="2009-02-10" version="1">MSANAPLRAAHQVGFDTDSKQIHVDNCATRSITNSEADCIGPMKPIMRKVKGIGGVKVTEMFEVTIEWTIADDHGKPHKIRLPKSFLIPSSPTRLLSPQHWSQSARDIRPLPRGTRCVTYEDCIVLEWEQRRHRRTIPLDARGSNVATFATAAGYEKFNAFCTDCSIDNEALDVKPLILNSSYVSDSEEGDNGDDLDDQYHEAHSSFDNEVADFKTGAPSTLRPGPINTDFSLDGPEQSNKADGTEATTSVIEDEGDLESQRNPSALFLRWHHRLGHASMTKIRMLAKVGLLPASLKECQIPLHSQALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L6</accession>
    <name>B7G8L6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_7867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183363.1">
        <property type="nucleotide sequence ID" value="XM_002183327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L6"/>
    <dbReference type="PaxDb" id="2850-Phatr7867"/>
    <dbReference type="GeneID" id="7195146"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7867"/>
    <dbReference type="HOGENOM" id="CLU_328040_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8L6"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866:SF2">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8687" checksum="E11D0966087E0DA6" modified="2009-02-10" version="1" fragment="single">GQHLLIDIEDVDTEFLDSEQHLAQAMVDLITLSGLTLLSYHCHALLPTGVSCVGVLLESHISFHTWPKSGVIALDLFTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9A8</accession>
    <name>B7G9A8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183603.1">
        <property type="nucleotide sequence ID" value="XM_002183567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9A8"/>
    <dbReference type="STRING" id="556484.B7G9A8"/>
    <dbReference type="PaxDb" id="2850-Phatr49040"/>
    <dbReference type="GeneID" id="7195294"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49040"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_1"/>
    <dbReference type="InParanoid" id="B7G9A8"/>
    <dbReference type="OMA" id="WERPWDR"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="68"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="248" mass="27806" checksum="2A90C92B7FCF5A9D" modified="2009-02-10" version="1">MVIRLTVAGCLKTRQSFSLQSKVNLKSVWPLLCKRFEAFCKGSGKFPLMTPQQSDCFMKTLDWTKGDQREAAVLLLLANVEDKPSIVFTLRASHLPQHAAEISFPGGHFEADKDASLIHTALRETKEELLPSDALFEEKVRILGMTSRILSLKGTPVTPVIAALWEDIPLKSIEQLFPGNPSEVNTVFTISIQELLEKETFQGLPKNRFGMKRTPAFPTLHGTIWGLTALILRPVLHRLLKPIFFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9K5</accession>
    <name>B7G9K5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_39772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>urea(in) = urea(out)</text>
            <dbReference type="Rhea" id="RHEA:32799"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183652.1">
        <property type="nucleotide sequence ID" value="XM_002183616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9K5"/>
    <dbReference type="PaxDb" id="2850-Phatr39772"/>
    <dbReference type="GeneID" id="7195206"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39772"/>
    <dbReference type="eggNOG" id="ENOG502S2GD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635336_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9K5"/>
    <dbReference type="OMA" id="IGQVMFQ"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464:SF4">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="45159" checksum="125725EC539AD81D" modified="2009-02-10" version="1">MRSLDGRYGRRIFGSLWPHQPQAYASVTTETINSKKREDFTARTRWAVQIFSRDQRLAHLGSSSLPRLFTVRNFTTTSSSTPKPPPQNSDDNQTDNPTNEPDTTWDLTTKSLGQVIFLNSSHSGTILLASLALGDPYLAFLAGVGTVTANATARNVLQLDAQVYGNGLWAYNGALVGCATAVFVAPLADSANTVAMLSPVLTGLAITTTGAAVSTAVTASLSRTITSMPQWTWAFNVVALSILLRTQPLRPTFDPNSVGATEMVAPSTTSLLELATGPLKGVSQIFVVESAWTGIGILAAIHAYSPLLAGHALLGSTVGMLTGTVCCSDAATAELAAGLFGFNAALTSLGVGVFFRNNTAAWVLSGTGAVATTVLFGALQNVLGALHSPCLTLPFCITMSACYQLGGRVGGPEGVVPSLELATNPHSPEQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9M4</accession>
    <name>B7G9M4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_30140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183918.1">
        <property type="nucleotide sequence ID" value="XM_002183882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9M4"/>
    <dbReference type="STRING" id="556484.B7G9M4"/>
    <dbReference type="PaxDb" id="2850-Phatr30140"/>
    <dbReference type="GeneID" id="7195645"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30140"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072710_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9M4"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="128" mass="15053" checksum="BD1FD16A442FE19B" modified="2009-02-10" version="1" fragment="single">MTPTGDEAEVLRRLAKTINGFLSRPDSGPFQEPVDWRGLELWDYPEIVPNMMDLGTVKRKLDREQYETAYACASDVRLVWNNCMAYNAEGSDFWLLAKAYSKRFEDRYRKLKAEFKIVEEETEEEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9N5</accession>
    <name>B7G9N5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183806.1">
        <property type="nucleotide sequence ID" value="XM_002183770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9N5"/>
    <dbReference type="PaxDb" id="2850-Phatr49151"/>
    <dbReference type="GeneID" id="7195651"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49151"/>
    <dbReference type="eggNOG" id="ENOG502QYGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_1"/>
    <dbReference type="InParanoid" id="B7G9N5"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="38493" checksum="A9365D4D13409B2A" modified="2009-02-10" version="1">MSFMKKTGKALADVIPGLGKFTFDSDLGTVFITSGTGVIGYRVALSLLEAGHKSVRVGIWYGDRQIGGDDKSFAQKCAETLEAKGAEVVDFDWGNEASFENALSGAKTVFCTIPHMDHWSDVFPTFLKKSKEKKVEHFIKVSFLRKGAAAERYRSNVQFAEFHGTCDDILEHAKSDSRISYTILCASHLMSTPLIHQGKMLREDHKFITASYGMGVNYVSPNDIADAAVVVLMDRKTHRNKVYNLSGPGPITDRQVSRLLTEFYGTNIQHIEMGYHDYKKDVKARGLPDWLVRDSAEFEKMKASGVDELSSSYSPDLEKIIGKKPETFKDYLQNKSCMRPGATFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Y8</accession>
    <name>B7G9Y8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183974.1">
        <property type="nucleotide sequence ID" value="XM_002183938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Y8"/>
    <dbReference type="PaxDb" id="2850-Phatr49241"/>
    <dbReference type="GeneID" id="7195703"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49241"/>
    <dbReference type="eggNOG" id="ENOG502SDKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333583_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Y8"/>
    <dbReference type="OMA" id="YLLMASN"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="857" mass="95207" checksum="F5E9CDEA3117F754" modified="2009-02-10" version="1">MADDPTAISPSEDFSQTVAHVLLACEELRRPITETPDEPTVLQAVERIRSWQADWDHVILPSLERLERHTDDASSSSWPQGGVAADLLAHCLQKAITVAQQVLTSATRMPEPTQEDLDTHEVIDASLDQIQRDIQGGVARLMEVNVLLWVRYRTRFGNLAEEQILNDLQLIELYVTYQKDVFRRRVTPAVARLKRARTSGNLGAQIPPVSLLPGARVQQHEDDDDDEATQASETVPVVEQHHAPVMANILGQALTLIHPLWSWFVQLPPPPSETQGPSEDDPLVSVIRAVCVESIQILDNQAQTIVKTLSDWFWVDQPQAETWMQQSIDSTTVHLDPAELGRLDGLVEEMAFGCKVQARYSAFLESTSLAGLQSTIASQLLPEWTWKYAALERFLATQQWQSALLLAAPVHIVIGTDIQVPSVVEDAQYLSTRALERAASTQSAQAMGTVAHALAHDVWSTEVNDNEAGAGVYVALLEQRASWKESSTHRNEKGGEEGIQPKTQEKSGFASALLDALDEDLSPDSPQPYTTSPEKGHRTPTAPTSGNFLRSFVGRNDESLQQMELEMQFCVLNGIHAASGACRSLVSLLDSLLLPLGDEEEEDVAATNAITPSRGDSKASSMVQLAREDLDRYASAYESLLAIKIKQSLVEWCGYRPDSTAPDLRRRRNNLCLLQLETFFTDENYELDSHSIQELEGDERLERNLFGPLKESSYLVQLADRIEPQVLHKVGEQLASAIVNLILNSLWNGQKRVTEWGSLLLSKEVRMLKEYIHKTVSPMVEESTLPPLAPELLDIWERLSQVVAVLQLEKPSDWIIYATSSVLSATDLQRTLSLRTDFSADAIQSVVRTVTQTTNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAJ5</accession>
    <name>B7GAJ5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184207.1">
        <property type="nucleotide sequence ID" value="XM_002184171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAJ5"/>
    <dbReference type="STRING" id="556484.B7GAJ5"/>
    <dbReference type="PaxDb" id="2850-Phatr49425"/>
    <dbReference type="GeneID" id="7195913"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49425"/>
    <dbReference type="eggNOG" id="ENOG502SDKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643266_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAJ5"/>
    <dbReference type="OMA" id="GHENENS"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855954" evidence="5">
        <location>
            <begin position="34"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="56311" checksum="B87B65E98A9B9042" modified="2009-02-10" version="1">MSLLSKRRMSPVLLCLLPVWLPLWLSSPTPCAAFWNVQTENGAAEVVDHDSGTHNRDADTPAEYGVDVSFPMHHHQVSNNYAWLPHNTDSSVPTPPEYRDMSVQPLGNMQARYDTFLQECVEYYGKKGERCVSTEQDRIAMSLRQPQSMQNYTELGYKKIRAPEAVYKLIREFWDRNNKEQKIEQWGVGNTYTNNWKAPTYMVSVEDKGLRGGGYVLKQKIWDAARDTIQEWTGEELTQCSLYGIRVYKDGAVLAPHVDRLPLVSSAIINVASEVDEPWPLEVIGHDGRAQNVTMEPGDMVLYESHSVIHGRPFPLKGWVANLFVHFEPTGHSLRHSADVEDLGQKDVHERYKDALARGFGGHENENSGLPPYLLPGTPEENHWRKQHPSGHKSQQKSFATGTTTAHVAAQKGSLGELKAEINRKKDAIHARDENGWTPLHEGARSGHLDIVKYLVELGADVNATTSSGGGTALWWAKETFGAEGNPVIDFLESMGALNAGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBV2</accession>
    <name>B7GBV2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184510.1">
        <property type="nucleotide sequence ID" value="XM_002184474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBV2"/>
    <dbReference type="STRING" id="556484.B7GBV2"/>
    <dbReference type="PaxDb" id="2850-Phatr49776"/>
    <dbReference type="GeneID" id="7198453"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49776"/>
    <dbReference type="HOGENOM" id="CLU_699201_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBV2"/>
    <dbReference type="OrthoDB" id="6500038at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="395" mass="44777" checksum="0EDABEDA9C5160BB" modified="2009-02-10" version="1">MELMMPTTDKTEEEVLSARAVEPSVNERLRTNDPSLTRLDVTSATFKDFSLYRKMDFLHSLRANSVVKTVHLSASGLQQVWTRIHLEELVDAICCLPRLEELFVFKADNHVFTEEILANALLRAEQLKVLMLWDFSDFRPTLAGAIRQLPMLERITISLPHDLPWAAMDVYVMGLAEHETLQCLSLRCQGGKCREAVVSPEAMHLLLTSTSIHTLYLENLGLTDDHTDAMADELRHSNRVLKSLDIKSNYFSDDALYTFAGMLPHNKTLTSIDLSGVVVTEGGGRKLAEAMQHNRVLTNLELEGYAERYVDEFHIPEASENTDWHRALDFYIRLNRAGHDCHQRPAFVESLNSVSDHLGCLYHVLRQHPEHVRNAANELQTTPIHIGSNFSIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC31</accession>
    <name>B7GC31_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184732.1">
        <property type="nucleotide sequence ID" value="XM_002184696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC31"/>
    <dbReference type="PaxDb" id="2850-Phatr49854"/>
    <dbReference type="GeneID" id="7198493"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49854"/>
    <dbReference type="HOGENOM" id="CLU_954619_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC31"/>
    <dbReference type="OrthoDB" id="41906at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="99"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="292" mass="32496" checksum="3CF9841B35F08D0B" modified="2009-02-10" version="1">MDNLELRMALNSEIAAQALTDDLKNRNAPMQLEKKKQTIANTTQTEWNIGSSVADSGSSGGGRFREHWPEHLPQPPSQRKLNAEELSAAESSKNPNMPKVIVFNANTHEGSSMVRVLSEKGLHVVAIVRIVTSRNTKNLMKLRNVEIKVADLNNKDTVMMAAKGCSQAFLLTKYWERFENPIEEQMAQVVLAASATVGIKRLVLATFEDTHELRTRGRKSQLMPTPEGKIYPNFEPMNSINTAAKKLGVQVSHMFTSFLDEPNSKKSLILIRGENGKILSQPYIQDTPGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC62</accession>
    <name>B7GC62_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_6756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184663.1">
        <property type="nucleotide sequence ID" value="XM_002184627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC62"/>
    <dbReference type="FunCoup" id="B7GC62">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GC62"/>
    <dbReference type="PaxDb" id="2850-Phatr6756"/>
    <dbReference type="GeneID" id="7198593"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6756"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="B7GC62"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066468"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="151" mass="16601" checksum="BDF3E8E5F54B0EBC" modified="2009-02-10" version="1" fragment="single">QVDLPEIQEVDTMAIAKDKALLAAQLANGPCLVEDTSLKFTALGGMPGPYIKWFQEKLRSEGLYNILAAYEDKTAVAVCTLAFCPAPHADPVLFTGECHGRIVEPNPGRGFGWDSIFVPDGCDEPFSQMSLAEKNHLSHRGKAVRRWADWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCE8</accession>
    <name>B7GCE8_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002184663.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="7198643"/>
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    <dbReference type="eggNOG" id="ENOG502STSY">
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    </dbReference>
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    <dbReference type="InParanoid" id="B7GCE8"/>
    <dbReference type="OrthoDB" id="41091at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
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    <name>B7GCK4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184887.1">
        <property type="nucleotide sequence ID" value="XM_002184851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCK4"/>
    <dbReference type="PaxDb" id="2850-Phatr49996"/>
    <dbReference type="GeneID" id="7198781"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49996"/>
    <dbReference type="HOGENOM" id="CLU_1513430_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCK4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="19611" checksum="9429E0B263271542" modified="2009-02-10" version="1">MTKRKIPQHRTFGDHSFWDTHCQSYPVFRRRDAVPDPVRLSSDSAIGVTDSVVANTVPVNPYRRIRPESIPAQRRAGDGSSDSCTSREHRREPSQNKTQAVNARLSKASLSRTGRSAPTSIPPSAESRDTGMKKPFPGTAYPSEQSSPTQSVQALFVHSESIPSNSSPRLLHSNGPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCL4</accession>
    <name>B7GCL4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_16509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184894.1">
        <property type="nucleotide sequence ID" value="XM_002184858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCL4"/>
    <dbReference type="PaxDb" id="2850-Phatr16509"/>
    <dbReference type="GeneID" id="7198784"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16509"/>
    <dbReference type="eggNOG" id="ENOG502RZU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1879466_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCL4"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47484">
        <property type="entry name" value="COMPLEX 1 PROTEIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47484:SF1">
        <property type="entry name" value="COMPLEX 1 PROTEIN CONTAINING PROTEIN, EXPRESSED"/>
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    </dbReference>
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        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="68" mass="7974" checksum="0D47EB2AB854C2D4" modified="2009-02-10" version="1" fragment="single">RAEVLSLYRECLRTARHFHWADPDTGQPWNARLRDAARQEFQQARNETDPLVIARLLVTGRDCVQQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCW4</accession>
    <name>B7GCW4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184951.1">
        <property type="nucleotide sequence ID" value="XM_002184915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCW4"/>
    <dbReference type="PaxDb" id="2850-Phatr50090"/>
    <dbReference type="GeneID" id="7198686"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50090"/>
    <dbReference type="HOGENOM" id="CLU_593797_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCW4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="461" mass="51355" checksum="90290D944941D3D9" modified="2009-02-10" version="1">MGEKNVSLKGNSTAVTINTLAGFLVETNTFSQKEIRKSSPLAHMPELVQPALIGGGERDIKEAHVEALVDQISILQLKSRNQSVEKDNLEKQVSIMNEVVCRTEMDHKKQIQILEGLAQEHQSVVRTVMQEKVILQVQVDDLKEERESLKAGIVQQRMTLEVALEQLAYFEKFLNEKGPISLVENDSQQKSKDIVLNAKLVPARDGPFSEDLGTISMENRKEVVSIAGECEKFLSSEGAEAGSLLTSRGHQEADSIKNRQNTQPDNKSLATSTEFNSSRPTLNQEAPYHPMRPSFRVTPSNTEGREIEDGRPDVTEKTRPEQTAFLTLPISSDSFSKPANNSVDLTLSRSTSDTLGLSSSESDTFQPFLDTGSQNLQSQHEPLGANITDSKEKTLSYSKGSSGSSVSSRMSYSSSTFSCRLHIPYQPRTGRRLLTGTVFMRNIFYRWQPFYAILYQCQSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD80</accession>
    <name>B7GD80_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_50182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185006.1">
        <property type="nucleotide sequence ID" value="XM_002184970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD80"/>
    <dbReference type="STRING" id="556484.B7GD80"/>
    <dbReference type="PaxDb" id="2850-Phatr50182"/>
    <dbReference type="GeneID" id="7198955"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50182"/>
    <dbReference type="eggNOG" id="ENOG502S563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_2_1"/>
    <dbReference type="InParanoid" id="B7GD80"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050406">
        <property type="entry name" value="FGGY_Carb_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095:SF2">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="4">
        <location>
            <begin position="326"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="60254" checksum="B0353C47210D00FD" modified="2009-02-10" version="1">MHNQNRVIVAIDLGSSSIRASAFSLVEADNDLNVVEAISGTSTSSPLALVEPNTGRIKLYLERDKKDETVFDAIDQCVDETLVKLRARLGRLAFEVVGVSFSNFVMNLLGVDEEGTVIGPEASISYACNSPDIAEEVATIRKQIGEENVRIHYQKSGCFLHEGYALAQLRVFYNRSVKNVCPEVTKWQTLASICLCRWLDQKSFPISYSEASWTGMLNYRTCEYEPDILNLLPNCCRRALPELADFDEPITLQKGIPSSSTYACRWPELRHARFFLGVGDGACANIGSKCSTMDQIACTVGTSAAARVCIPMEIGAADFKILPGLFCYRVDRHRVLVGGALTDGGSVVEWARQMLNIKESGAFDECMHKVSMLLDARYIQSASEDASFARTLTVVPFLSGERSTGFRGGATGAILGMTRDTTPAHVLLGCIEGVTLRMNAIIALIRQATEGDRKQRLIASGKALEVNELWRQMIADCSGLDVVLDMGTSEGTSRGAACLAAESLVSSKETSTAALPEQSTMSVVSTPDQNGAAYWRRATTSQEVLINALSPIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDW8</accession>
    <name>B7GDW8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185330.1">
        <property type="nucleotide sequence ID" value="XM_002185294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDW8"/>
    <dbReference type="PaxDb" id="2850-Phatr50370"/>
    <dbReference type="GeneID" id="7199192"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50370"/>
    <dbReference type="HOGENOM" id="CLU_682358_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDW8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="266"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="404" mass="45052" checksum="9F3B5B551A890546" modified="2009-02-10" version="1">MTKDCLDGDSGLHGAFSISPTRFTVPTSRFRHNAGTVGRQRPWKSHPWVASTMEPALGRGPARSLSCPHKHHYHYHTPSVEGQFDNALEEDPVLPPARARFASVPPPPRSGNNSLRHDRSQPTSLRLRLAPKENSTLPQHLVPSHTMNRPTPVRTVTTTHVQQPPPPPPLIHSTVVVRAISPPSPWTHTPPLPPPTGARLPLSPRPVPKLVPKLVPTSHYHHLSHPSLKIIPDYRMDPAMRLPIARTVPSDWEHQTSPVVTLAVRDILLGRGGGTNQHAGNLWYRALLQHYRLAYTQAPKFDKAQLARNLTNYIRLCGGRFLQKGTLAQPPGAVSVHRHGNGGDCYYEVGDVRARLKVTQVLREEPPNTRKRRRTRTEEETTNAPLTAAAMFEQHQQQSSAQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE75</accession>
    <name>B7GE75_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185388.1">
        <property type="nucleotide sequence ID" value="XM_002185352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE75"/>
    <dbReference type="PaxDb" id="2850-Phatr50470"/>
    <dbReference type="GeneID" id="7199316"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50470"/>
    <dbReference type="HOGENOM" id="CLU_576808_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE75"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="395"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="54098" checksum="2176811B0139DCBF" modified="2009-02-10" version="1">MVKAKKSKKSKPRKEAASNNGTVVYTPSSSHVSAVSGSYKGTKEDLDALDWLRNVENRRSQGEPVLQLEYQEDDVLMTTLQDFLETSAATHEVIDEIYQIWQQTVLSTLLASSALWKQETVQANDQRVLKDCLKTARYKINFALHHVLGAILTSPEPKWKRLQPYVIDVCWQTLALLPRLAESVPHHPTDLRSNILHFEGKEFLASVACETWDTLYDFDISLDPTRFVPILRKLAMLDILDKDWNMLGGWEDILKGLEAKCFHGSVLRLPCDSVLHEHTTLLRNARNSMQCKFFSVRFMRYTEDQAPQRWRYFPKCAAPACAHVETPESPHPHRCESCWYFHYCSPACQEYCDVVLGLHPKFCRDTPANKAASCQRETEAYLGWSDPQSGQPLVCHACGVVQEEVSGADSLVDAQYAIVSNGIPTSSMKRCSKCQKVYYCSRQCQEWDWRVGGHKRVCLFEAAQKQQQQIKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7S450</accession>
    <name>B7S450_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176339.1">
        <property type="nucleotide sequence ID" value="XM_002176303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S450"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1686"/>
    <dbReference type="GeneID" id="7204894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1686"/>
    <dbReference type="eggNOG" id="ENOG502QPS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432455_0_0_1"/>
    <dbReference type="InParanoid" id="B7S450"/>
    <dbReference type="OMA" id="IEHETME"/>
    <dbReference type="OrthoDB" id="206902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="633" mass="66597" checksum="BCF6CF39A336AAD4" modified="2009-02-10" version="1">MSSLLIHAAQSAAQADGLSVPGHRLEAAHSMAAPPQQPHPALDVIPNNKKKGPPLRRGKWTPEEEAYANRLILEFKSGLLPLTDGTTLRTFLSKLLNCDPMRISKKFVGSNCIGKQVFRRRTADLNRLTPEQIQQSRAELSELERRFLERVAQTNRVKSSGVGGAASAAPEAIIMGRPKIEHETMEPPSPPWLQPPFGYKQGAGAAFAAANLSGSNSRAAAAGRAMLAGTSGLNGDRRASGMSSQELLAMAEFQRQASQSTMMQNPFHQGSATNLLAATRSGSSNGLSSAAFSQLAQSVSAARLSGLQSNNASMNNLMLKTGLSREQLTQLARDRGLSSDSLSNMIQRQNSFDALMSLDFQSLQSIDNLANLIQTGTAGSHSNIPESGMKNADFGYSSRQNITGASSGDLSNAARRLASAGRMESLLQSMSNNNFHNNGIGGNNDTPDSNVNLNNLLQSMHGGSMLGMGDRSSAASLLGSGNGPSAVSLANLLRQDSSTGLTALRMQDGLNQRNSSVDDFLSLVAAGDIPHQDPSLLNVPLMHQQGPPGSSEAAAKLMAQQQMLQASGNSALANALASRSFGNLQNSHHSGGMHSTTSAAALAMAQARAAANGSKRNLDYLSGGYIGQGDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7S453</accession>
    <name>B7S453_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176341.1">
        <property type="nucleotide sequence ID" value="XM_002176305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S453"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1366"/>
    <dbReference type="GeneID" id="7205060"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1366"/>
    <dbReference type="eggNOG" id="ENOG502SB5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1392603_0_0_1"/>
    <dbReference type="InParanoid" id="B7S453"/>
    <dbReference type="OrthoDB" id="410714at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002863534" evidence="2">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="196" mass="21415" checksum="04CE1C95821C77CF" modified="2009-02-10" version="1">MSLFYVGTLFLMLHSMMQHVFGFASLHTTTCSELLRKTQGPQLITQLSLVPNSVDHVEMFNIASHHLYSFSIADAATQLQKQQSPQELGQTKTETTLIFVAGLVPFVWATVEFWRRIAVGESFGTGSDSIVIIGEDDAPESSRGRRVLGKGALFTAYVLFTISAAVLGIVLFSVLATDTVSFEEYSAGLGETITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4C2</accession>
    <name>B7S4C2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176368.1">
        <property type="nucleotide sequence ID" value="XM_002176332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4C2"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1443"/>
    <dbReference type="GeneID" id="7204943"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1443"/>
    <dbReference type="HOGENOM" id="CLU_777227_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4C2"/>
    <dbReference type="OrthoDB" id="48765at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="41341" checksum="945D8CE4D34DD423" modified="2009-02-10" version="1">MNMQCEVRPRYNKFEHEADPFVPLNRPSPVLQKVQERWGNGKSSSPDDLKNTVLDESQHGRNRGKGGKTEMGVNEKKFRTSCKPRAPQKWDFGKRRTFALPQINRKNNDAATQIQRISRGGWQRIQYKVLLLQHRLNTRTSRTEASMHRVREKTEKRKLALRQKLEAQAQRELEKVTTEEATAQEGQQIIHYLRKENKKLRSKNQKIFAASHALKNNNDRLENANQTTARGFGTLNDHAKQIKETHDKLNNVVPKYKESVDKLREAVEERRQYCLSEHTIKLLYIKLIGRVVEIVEDSCKDAKLVDEIVGYCLEMEGEENRLELPKPLAEVSKEKDDGSVASSESDNYDEYTVATMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3E1</accession>
    <name>B5Y3E1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polygalacturonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_46668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185635.1">
        <property type="nucleotide sequence ID" value="XM_002185599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3E1"/>
    <dbReference type="STRING" id="556484.B5Y3E1"/>
    <dbReference type="CAZy" id="GH28">
        <property type="family name" value="Glycoside Hydrolase Family 28"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr46668"/>
    <dbReference type="GeneID" id="7204408"/>
    <dbReference type="KEGG" id="pti:PHATR_46668"/>
    <dbReference type="eggNOG" id="ENOG502QS6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_0_1"/>
    <dbReference type="InParanoid" id="B5Y3E1"/>
    <dbReference type="OMA" id="VGDDCIT"/>
    <dbReference type="OrthoDB" id="38244at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50861" checksum="F2BF4E51E20E5224" modified="2008-11-25" version="1">MGSNAHRHLELDVQDYQSSQNGGRRDDTAAFEQAIDIIRSNGGGRLIIPGAPDGSFNLYRIRPINLTSHLVLFLQKNAVITAIADESVWPLIPPLPSYGQGRDHVGPRYSSLLHGEYLTNITIRGEPDSPGIIDGQGRYWWDRRRHNRDRYTRGHLVEFMYSSRIRMYNLRLQNSPFWTNHFYDCDDVHVQNVHVKAPWSSPNTDGWDPDSSRNVLIEDSTYRGGDDCVAIKSGWDCFGIDYDTPSENITIRNVTCQGPYAGIAIGTEMSGGVRNVTVENVTFTYANKPANIKTGNTRGGYVHDVVYQNIRITGHIDQAIHVDMYHYHNTPNPSCSNNYQPNQLPHLRDLYFFNFEGTQALTESHEVFHFVGLPESPIEYVFLENISFPTPVSSLGWNCSNVQGSVKNNSVTPWPPCPEFPSVTVENSETMSPWNAFLTFLFLTTAVLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3J2</accession>
    <name>B5Y3J2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185666.1">
        <property type="nucleotide sequence ID" value="XM_002185630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3J2"/>
    <dbReference type="PaxDb" id="2850-Phatr46708"/>
    <dbReference type="GeneID" id="7204500"/>
    <dbReference type="KEGG" id="pti:PHATR_46708"/>
    <dbReference type="HOGENOM" id="CLU_266229_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3J2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138400" checksum="10CE2F7669AB88DA" modified="2008-11-25" version="1">MLSTTNESTKQRSWWSRYTFKMHPIHQLVLLAVGRILVHRDSVVLGVNAYARASAPPTYRSGPPPAPVSASSFTYTPQSTNPRIELLLDRTVLLYDRASSQQRQSYEWMIDQLTSLIVYLGQLLSTQSMAQSAGPTAQQMALQIENALLRDMDEEPIESLVESLGSLRQTSRDLPYRDISSELQAVELQIQAFQRVLVSTQPLPDTGDTPSWFREYSGQGRGMADMGGTQTLVDGNANRDKQWSDIIRVGMQIEEASQRGVDPSTIESLVDAYWRGDEKQIDTLFETMEQEVEAAERRRPAKFVVPASVSAVAKQIEDALLMEGDSDPIEALLKANRQKTASVSSLSESATIEVPESDVAAAPATTPGNLTGAPQLTTDIKAKPGFLVATKENANTQFDAQSDELNVFVEKYYDSKYDFTKADPKDSVKMIGLALEEAMEKGYDYDQIRALVEAYAVAKQLNCREEERKATTLKEYAPTSIAPGTLSQPKGQAKRAIYSPFEDLIRQTQQYLGAGGNSQSIVNKATGQAPATVRSKSLFPSFFGSSQVPSRNFKDRKVSVPNGIISTSLSPKPKEDGASRTTIQAPREGKKASFDARTMLGIKPATNSRRVKPVSEESYAVQQFRIEVEKAERAMRTARINKPRMSKEEEDRRRAADRRRRRRQRASPFYFAEVSSTETAPPGRRSGPGVRGQKSNRNNPEVIQYARRMKEIMRARQRDANQRAQRKLMEKRVEERKKLEQMQQFSSDISWTVKQGMGTIEDFVVSSGAFIQKVMNTPKEVNALLEQKRGISQSMRPPKFATTIGPSNIRTQDPSPYFFAEVVGIERSTTEQIAEAVFRAIRLKDAVVDVAVKSGPILKNGAELNLWAWKQLSEALDKINQGEPIIPKRRKNLGTDENIDQAAPTEGTQAVNLHGEPWSNLAREWDERNTDSDDHFPLDPAPPVTQPPLPKFDVAPMESQEWAASESNRDPVLSNGVHSTSYRDAATDTGEWGWLAGPWANSELAGNQEGGGQQVDVTYNDLAKEWAARNSDENFDAPFGRSSSVLAPDSMGNRDANGRNAKYSDSRKPSTSSYLGDLMECTTEEEIVQMWGQVYRVEYIQRRANYVAEKSFPESIDESDDFCADAVCSPESLRELDSATNGDSSCQAGAASAEEVDFTTNASVRAPQQPLWKNLANEWLTMNQDSAEKQIDVYTQREKGRNEELSPSGSKSGSGHQGSALTYIETPWQELAEEWNSINNDSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3N1</accession>
    <name>B5Y3N1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185867.1">
        <property type="nucleotide sequence ID" value="XM_002185831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3N1"/>
    <dbReference type="PaxDb" id="2850-Phatr46743"/>
    <dbReference type="GeneID" id="7204518"/>
    <dbReference type="KEGG" id="pti:PHATR_46743"/>
    <dbReference type="HOGENOM" id="CLU_1306974_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3N1"/>
    <dbReference type="OrthoDB" id="49707at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838758" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="211" mass="22994" checksum="347793FA46CFC825" modified="2008-11-25" version="1">MKIFSSSFTTVIVLLAISLSTAEITGEFDEILAKELPRQVEIPDVFGGRGHRRSCAENGKVAAWCNTEHTPSLACGILPDFDEYGCACLGDASSCPDECISGFTPSAKTHYGIRCQGIPPDEPNYVLKENHALNRCENNAVVSSWCDDFVNMHLTCKLHEDVDEYSCHCGGKHSACPEDCVGGLTPIETTHNVIRCKGIPLDQPNYILKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3S7</accession>
    <name>B5Y3S7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_36830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185891.1">
        <property type="nucleotide sequence ID" value="XM_002185855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3S7"/>
    <dbReference type="PaxDb" id="2850-Phatr36830"/>
    <dbReference type="GeneID" id="7204661"/>
    <dbReference type="KEGG" id="pti:PHATR_36830"/>
    <dbReference type="HOGENOM" id="CLU_932098_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3S7"/>
    <dbReference type="OrthoDB" id="48156at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33105" checksum="453D3BCADDB35894" modified="2008-11-25" version="1">MMNQTSKCNANLSKNKERDTEEVACFLLSLKHNSDRSATVSPDPEQNQVEVIQTSNHKPPQFSFASLSDSSIGSKPYASSNFDDLIIDSNLVYPKDRDLVPDALFVAMAQMNPCTLTHADRVGCYKAREIGFVGMSCKFCGGQPGFGRFFPASIRSLAQTTTSQTIMKHIAGKCRFCPPQVRNTVLDLQREQALRESMSSGRPRYGSRKIFFQRVWARLHDVKDAIDEDNKTIATADESASNSTPSGTDDISLSSISFGEEDGGISAGLLRQKRPRFGMLPTQENKRAKYGEEASLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4A1</accession>
    <name>B5Y4A1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185802.1">
        <property type="nucleotide sequence ID" value="XM_002185766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4A1"/>
    <dbReference type="PaxDb" id="2850-Phatr13320"/>
    <dbReference type="GeneID" id="7204466"/>
    <dbReference type="KEGG" id="pti:PHATR_13320"/>
    <dbReference type="eggNOG" id="ENOG502S9K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063787_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4A1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="163" mass="17549" checksum="3A4D462A4F5CE6E0" modified="2008-11-25" version="1" fragment="single">NGGVAWFQKQNYDKVGPDVKAAYEFLKTKIDGKPVGGLGFCYGCWLLSKASSTGDIDLVAGVGCHPATVLEEAVFGGSEVGMLKALKQPTRFLWAGNDSETYLADGDGRKAVEATGGDVIEFPDMLHGWVSRGDVSEAKVKRDVEKAMELILIFLDEKMNSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4B5</accession>
    <name>B5Y4B5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185808.1">
        <property type="nucleotide sequence ID" value="XM_002185772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4B5"/>
    <dbReference type="PaxDb" id="2850-Phatr46954"/>
    <dbReference type="GeneID" id="7204770"/>
    <dbReference type="KEGG" id="pti:PHATR_46954"/>
    <dbReference type="HOGENOM" id="CLU_807675_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4B5"/>
    <dbReference type="OrthoDB" id="90541at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF251">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="391"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="720" mass="81636" checksum="85042D30E8E14BC8" modified="2008-11-25" version="1">MASSLAKFTDALSQLLTTESLQKAIDELKNDLQSWDALIAFPVVLPVLPGMPATLSYCNNLLEYTKSKYKGQKVYFCQSKYPLHDGWEVLKNDLESAALEQGSAIISNGGGTGNARNSKKLICKCGRVYQRGLTDKDKVKTFRNGSLHSDRKNSRGPNGKRMPRRTSSMRPDNANSVCRMSFTIKWDKNGYYLYCGYGNIKHTNHVKLAGKHMTFPKRLVADAERDVVESIGAAKALHAVARNVHFQRTGRLLSHSQVRYMHNMAEKITMALLVDGSSINIDALSDSERMFEHFKLHGVNYSLLYNHVPTELASNSTSTSCQATVDNNSLTSCLLGMTDAVKLPPKENEDMLRFANEHRDSYKLENSQKLMIGCAWIHPKEKRLFQLFPEVVHVDSTADTNKEGRPLLTMTGRDSSGKHFTILRVFLPNERAFVFRWLFRLVLPSLLGTKWTKRIKVIITDGDSQETSQLDIAIALLFPDVLRVRCGWHIVDRGWKRKCPGYQLVDVCNRNKFEVVTKIIKSWLYSWMQPWQCETEKEYNISKSLLFAYMQSLEVVSVMGQQNASRIFQFIRENVEPHESHYCFHKRKTVRHYDTFVNSAHEGTNNGLKNSAAPVLPQYTIDQSASVLTKNASVNTLAKELAAGQQSIRHKLWSDLPTSKHLNTLGESLIVKEWKLHKAYGLERVALDTFHVKHCNPKPVMVKQSAPIPLFQRAAALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4D2</accession>
    <name>B5Y4D2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M11 gametolysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186271.1">
        <property type="nucleotide sequence ID" value="XM_002186235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4D2"/>
    <dbReference type="PaxDb" id="2850-Phatr33107"/>
    <dbReference type="GeneID" id="7204246"/>
    <dbReference type="KEGG" id="pti:PHATR_33107"/>
    <dbReference type="eggNOG" id="ENOG502SRDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538037_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4D2"/>
    <dbReference type="OMA" id="NECSADR"/>
    <dbReference type="OrthoDB" id="48545at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008752">
        <property type="entry name" value="Peptidase_M11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05548">
        <property type="entry name" value="Peptidase_M11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841257" description="Peptidase M11 gametolysin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M11 gametolysin" evidence="2">
        <location>
            <begin position="195"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="507" mass="55021" checksum="59167E73A712FBCC" modified="2008-11-25" version="1">MKHGCLFLVASSLFASNSNIIAYASSVRGALASSESEMTGSSNSRRPFAANDVLTCRVTVVGTMLDINDDRSQANQDEQISCIPIVDEKELDNVFPLDLPAKVLAVHMSSIERASLYVAVKGAYVTEDQLVVSDKAAYEVFNELPGHLRRLEEQRRDLFTTGTKTLGVVRISTTDAQPMFSAAQLEDGIFGNGLKNDGVTVVSQYEECSFGKLKWGKTREGVVDIKVNQSIKSFKSASDLVTAVQKQIKAERGISTVASLGDKVLMCLPPGTGSWAASAGVGHWRAQFNNEWCLSLTGLVHELGHTMSLGHSAEDGIEYGDVSGMMGYGRRNANGPRKCFNGYNNFRLGWYSDRTMKVDPSTSPRVYKLATFVDYDKTNSKEPVLINVGDEYFLQYNRAKAFNSGTEEKQNLLTVTTDTANTSGSTNLGGFRSGETFNKVSNYQSSRKRLVVKVCDQISGNGSSPDALMVSIGLDGSACGQVQQPDDKPSFSIDKAIILTAAKTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4G8</accession>
    <name>B5Y4G8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186289.1">
        <property type="nucleotide sequence ID" value="XM_002186253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4G8"/>
    <dbReference type="STRING" id="556484.B5Y4G8"/>
    <dbReference type="PaxDb" id="2850-Phatr43831"/>
    <dbReference type="GeneID" id="7203963"/>
    <dbReference type="KEGG" id="pti:PHATR_43831"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609018_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4G8"/>
    <dbReference type="OMA" id="DWDSLFI"/>
    <dbReference type="OrthoDB" id="3510at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35279">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35279:SF1">
        <property type="entry name" value="ARABINANASE_LEVANSUCRASE_INVERTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841260" evidence="1">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="450" mass="50067" checksum="55B56569EF0B1E07" modified="2008-11-25" version="1">MKWIACTCFGWAVIGPTHAWLSSPQTSPNLLHRRRSHSRLAATSSNQNVVLQPSDDPARFDSFQIGNARVHRYSLNTDPESQTEYVMWYHGRDAQFDSDRALPPLSTGRIGRAKSKNGLIWVKDEQGNFSEDVPDVSLGLNKESWWGFDTAHVGLGNVLLPMSTPAVMTEGGVYLMYYMGGSFEETRMADYLDDSKIPDNLKDATIKGMNLRIGVAVSQDGVSWGRVEGDDPTGACMVPYNKADPNQAGEPVPANMPEELYCGWPEVVVNLVSGNKAEAFLMFYSTMLKETKEKVIAYAISEDGFRWFKKGLCLQPDKDGMDAAGCARCCVVRDASFDEETLRWTEIDSWKMYYEGISLEDNKHRIMMATSIDAQNWHKKGVILDVGAEEDAWDVAGVGSPHLVRMDDGSLRMYYTGQGKDGSTAIGVAKFVPRETDGEWIREQATISFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4M8</accession>
    <name>B5Y4M8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Timeless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIM_2</name>
        <name evidence="6" type="ORF">PHATR_33206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186038.1">
        <property type="nucleotide sequence ID" value="XM_002186002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4M8"/>
    <dbReference type="STRING" id="556484.B5Y4M8"/>
    <dbReference type="PaxDb" id="2850-Phatr33206"/>
    <dbReference type="GeneID" id="7204296"/>
    <dbReference type="KEGG" id="pti:PHATR_33206"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008627_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4M8"/>
    <dbReference type="OMA" id="RIACECK"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="5">
        <location>
            <begin position="72"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="944" mass="105998" checksum="B4A98A72AE4DD4FB" modified="2008-11-25" version="1">MTSTIGVTDRRALAAAQSSPPPRSSAASRRVTPPRDALSVEPSVVDELLLVCGVIGTTVSDTDTPDRIVPVADCLNWLQDLQRALRRDDDQYRPISLLMAQWKIVPQKLLPLVDSCRYDTDLVLTVAKILVILTKPLAESTERAGKLPIETKTKTTEAVIREQIRLRENAVQQAEARMEYKRAICHYHHGHTHDSNPTKSGGGILSIFVSLLAEPLSKSGTARTEADHLKIELVLHLFRNLLSAEPLLHSSAAAVAQAQTLHDDCVVLLDQELVLEILLVLGADIEQRENLQYNLLLMELVHHLLRHYDPAVVARAVPSPTGAAAALPPKPRPGLLSQSLQREKQKFHAPIMSRHAHFGGTLVVKQAHNPTQQQYVSTAALGPGHRSAPLASKRKTKKSEPFIGSKSHPSHHTRTAATLTPSRQKAVAVLQAFCQRWVQDCYGPVTKSLKHEFRRDSVRLEESDRITFFRMVWFFARWWRLSPAAVRSRQVQQDDTVSNQSAVGQLIFTMDVFAFNLVLNATDTFQQHKKYARLALTVALLGEMMHLLTAMYSSQESTEQIMAMGLMDRLFYGSEPLDRLPKLLSSWQPGSSTRDYLCDLVEVVHVQLKLLDTHAQACRNVDTSQAKHDTVAKMKLAAADFDTTHYLTRRIISNHVVYMYTQLLTQYDVNAAHVNHRIVAFLLRLTKLQIAGTVEPEDVVLPAQKLLTAPNVTLQPMLYNFQVLRVFQTILNDKSIRRDKDYVTLLAFAAGIVHDFAQAAERNPVLFVEALFKHPVPHRFCEYSANLYVTEELRMIAERELLLEEQRKFEEQVAAVRDDDDSEDELEFEDLEVESEVATKTVSLGSKRKVLYDSDSDEGETDPAPSLPAGTTSSREVETGDSEDSSDDDEKIRESLEQEHSSILGDFAKTGVVDPDHSSDEEEFDRWVEEPPLKKKRSVDEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y568</accession>
    <name>B5Y568_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_10418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186131.1">
        <property type="nucleotide sequence ID" value="XM_002186095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y568"/>
    <dbReference type="STRING" id="556484.B5Y568"/>
    <dbReference type="PaxDb" id="2850-Phatr10418"/>
    <dbReference type="GeneID" id="7204231"/>
    <dbReference type="KEGG" id="pti:PHATR_10418"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_1_1"/>
    <dbReference type="InParanoid" id="B5Y568"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF5">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="375" mass="41462" checksum="F4FD023A3AAB3471" modified="2008-11-25" version="1">MIGQYAAEWEAKGGIFSLAQGVVWWREPTSSTQALISALQEKDSMLHMYGPDEGLIDLRDALQEKIRDENGLEHHQVMVTVGANQAYVNCVLTLVEEQDKCVVFKPYYFNHVMALQMTLPKDCLMVGSSSDDGIPDLKWLESNLRQDSSIKMVTIVNPGNPTGTLLSRDFLQKAVDLCRYYGCWLILDCTYEYFVPRGSRFDGCFKDPHVLHIFSFSKAYALAGYRCGYVTVSRDAHGVYEEMTKVQDTIPIAPSRISQIAALGAMKAGSSWVEEKVATLDTGRSAILKALEPLDQIMGGSGAMYIMGKLKDGSDDQEVARRLVQEFGVAVIPGSFCGSPGWIRVCYANLPPEKCLEAAVRLKKGILAVEEDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5G5</accession>
    <name>B5Y5G5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186181.1">
        <property type="nucleotide sequence ID" value="XM_002186145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5G5"/>
    <dbReference type="PaxDb" id="2850-Phatr33500"/>
    <dbReference type="GeneID" id="7203888"/>
    <dbReference type="KEGG" id="pti:PHATR_33500"/>
    <dbReference type="InParanoid" id="B5Y5G5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="21641" checksum="5B26BF3C3BD3F70E" modified="2008-11-25" version="1">MTTHGKSLGKNRRLLHLLPAGSLKSTIFDNLIASLNWTALSPREDTGSKSNLTTSWNMKRSHCMTSIFQVDGKQLKDTVPYQEFDKEATGNKKWMGMGVVVGIVAAAFGLILHPFESTMTEVVQEMALQAAQHAVVSVLTAMATSVGAGIVGPVTEAIARDLTGMQTGIVVEIVAMAKVMVSMGVVISNKATLLTIFQPQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5K9</accession>
    <name>B5Y5K9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-Nucleotidase or metallophosphoesterase</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_44174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186201.1">
        <property type="nucleotide sequence ID" value="XM_002186165.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr44174"/>
    <dbReference type="GeneID" id="7204094"/>
    <dbReference type="KEGG" id="pti:PHATR_44174"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256393_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5K9"/>
    <dbReference type="OMA" id="AVVEISW"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1370" mass="152684" checksum="FB1BB520D89D1EA2" modified="2008-11-25" version="1">MKIPSRNRWRSRPGWAVAILVSCGSNRVDGLAFQQSVRGGGRAASTPDKVDRVETWEASPCQDSECRLILCHITDVYTLEHLAHFKTLVEETKKNSEGSAVVSVLTGDFLSPYLLSSVDRGEGMMHALGRIPLDYLTWGNHEADINHRTVCQHVRNFAGTWLNSNMIDHEAMDAQKEYDVIELTSPDGSNHRKIGLAAVLSSDPALYAQFKAPGPFGGATVTDPWEALAKYKRLLEKDHGVDLVVPLQHLYVPDDHKTCHKFDFPVVLSGHDHHRVDEVVDGTRLIKPGMNAAYAAVVEISWKTSSSEKPVIRSRFLRFLAEENERAYDALIPLRNTELARVPSNFEPLTSNNSRGSVCTMGSFICSLLRSSLNVSRRQRDNKVDAVLLMGGNVRGNADYPEGSFFSLEALEAEIKSDEVIAVVNMPGWLLAAGIEATHAGDPIPGWMQYDVGIRQDENNVVTQVAGLPIDRERVYRVATKIGDLTNGQSIPLTQYYTENRHLLPPKGAYVNIQSELMAYFARNLWRKLWDAVSLELAETCDTDNDCNPVGRLEVLDKTGDGEVSVAEIQTALRDLLGYSVDDRETSLAKFVHSFADTTSTGRVTLRDFEIFCDEMEQTYERDSWRLSYPKPSSFEIVCDARAPRGSQKFCKFGFFVVVTNFPSGPILPLPSTISIFTVFMRSKMIIREHIPVKIVASSPNDSAQILKKDDFCTKGTMKTLQGLLPPTFYLMGFVPFWSPVRTAESFSVARQPHAGGGRAPGQPNKIDTTESWEVSPRSDSECRLIICQITDVYTLENLAHFKTLIAETKKRAPGSTVVSMLTGDFLSPYLLSSVDKGAGMMHALNSIPLDYLCWGNHEADIEHHITCRHVRNFHAKGGKFINSNMLDHDAMDAQQEYDVIELKSEDGTNTRRVGLTAVLSDDPALYSHFKGKGAFGGATLTDPWEALTKYKKILEDDEKCDVVIPLQHLYVPDDHKTCEQFDFPLILSGHDHHIVDEVVEGTRLIKPGMNADFAAVVEISWNDATEEKPKIRSQFVRCKDWAPDPVMAEENERAYDSLLPLRNTELARIPSYYEPLTSNNSRGSVCSMGKYICSVLKSAFNMNRGKKNRVDAVLIMGGNVRGNADYPIGSYFSLEALEAEIKSDETVGVISMPGWLLAEGIEATHCGDPIPGWFQYDVGIQQDENNVVTHVAGLPIDRDRMYRVATKIGDLTNGQSPPFTEYYQTNPKSLPPKGNYVNIQSEMMSYFARNLWKRLWDAISHEVEDTCDIDGNCSPEDRLDVLDSNGDGTVTVEEIHNALRDLLDYSVDDRETTLAEFVHAFADTDGSGKVTVKDFEVFCDDMAEQAVINRALAREAMERQREIAAAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNZ3</accession>
    <name>B7FNZ3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177127.1">
        <property type="nucleotide sequence ID" value="XM_002177091.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr42624"/>
    <dbReference type="GeneID" id="7195988"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42624"/>
    <dbReference type="HOGENOM" id="CLU_237042_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNZ3"/>
    <dbReference type="OrthoDB" id="57475at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1819" mass="205414" checksum="44B85BC5B6AB89C9" modified="2009-02-10" version="1">MTTSALQGLARYLNDGFEYVRANLWNVAVALILLHFVQRKFKDYFVSRGAAYRLTHTDAVRASTGSDTTSAGSSTKSRNEQLRAARERQQEFANQKAREAAVERKRKAEADRTRKNRIVADQAKIDRAGGRTIGEATSTEAVNNMGYNTVQPWTGSTGGYRILGPYDYQYLPASTEILGKQTRYLLNSLNSQRKYVTVNSQLLYFHTPNCMCDDLPHDLLLNLIDAAKKNDTASCASLLGHRKLASKGLNCSLLKCSASARKIQRRLFPLHQEKECTTYSPDNFENLVEALMLSPSAYETPYIVACEVLEVGSSLGFSTISTILVHIQTFLRREITSWLDRDRKLVQNSRIARSVQPLGGESLAKRSPKFWILKLVKIISGVFNYQLPESAECDGVYEEVESADDWTAPLKLLPLLISYTRQIDFSVHEDIFDAVFSDSCRSDRLLVWIHLASDHRLHLRDREWDRIEGAVESTLEMQQFSVHFRQAAELSKFILSFCSFFCATSSQVRLLRWQILLLRLLSEVAHDVQLYFSVEAEIETGLLLLQSSNLRKLSVSFSSSSFETPSFVLVNVLLLFIRACQLSGLKLVGDILSNTAIKEVQGLVFPVCWNKIVLLLSPKRIRHMKTENNQNMFNAVFDGAKYIGGGVFKKSELPITELCASGAIVFQSLHLFGQANTFGSDMEYISKSMTYRKWLGAVEQALDLMVASKKRLHCMAVAVVIVVLFCEISASRKFIIEILLNTLSADNVRIPLEQSVQELQSLFACDIITVILESQAFGLLVRTEECDLKNLVAIFDQELRLPVFTHIITTIFPLPAARKVMFDRAKRILDTCSATVRFSRCGFPSTNEAKEKLSFLSLEKKFEEDEASIKRSLVIMCNLICLKNGEDSGGWDVLQQIIVSNRPVLPASVRGWLFVLLRSIVRKNQINQEYRCRLQAACVLRFWKFCLEAIDTGSGGRLKVSSALDGWSDSMGLAGMRSILVEDLPKLLQLILTMADEYSVRDKKHNAFLVEFWRKNFWTMLHVMQNDCTQDRLFTLRATDFGGPGDLMTDASMRCIALALNAILNININVVFSGLNFSEAATELDFRLRKQTDVLSETTGMFACKAEGHIDSKLHPEVSQIELALFDQILRFLLGRKDVDGELNGETSTPATYHCSLCDLLVSRQRIAAGIPSGQESCWVYCPDAECVCDMIDGFLRVCAPSIPSLFETEEDMFAAERIFRIIPDLCSQAVSACEEASPMETKDCHRMLRIVWNLYCIISKEDKAKNLITFFERHRCLNEAAKIKAVTPPEWLEALQCSADVDCAVQDMRRSVLEPLRLCLIALCSSGKSDLSGTLDVHLVIEYLMSVVVGCSDDLLVGLRGESGGVTTDMFSLFIDCIRYAAESIGRIPLFFLDKQEMLKACYVCKASTQAIWKLLKEYSVCTAALFTKSASQCFYHLPAVCRKIKRASFLKWGTCVYEFDETASLLEAFHSCHKALLKNTASDNLIVSEPPTLGSGSSDDSDFDPRHTEKDCDKRWLELQLDSELVCGQTFCCIFDSLEWTWAEYQDLLDSTSNDWLGHSQFAVYCPQQISARQLAFWLVSLLFSSEYLDPNDAHKVAHACALSPQAKLRLVFLLDRIVSVQLESLKILGAMDIDMLESKLNGCFVEAFCCSVPWLTFEAKVEKGFFQTKNVFLQRLSKLASRLDTLETELNHLKQLGLSFQTINKLFDAERKEFVREKKDEGTSIFDLTLLIAEKLDVLERGRLELEGITLIDEHRRKKHKESKEIHVNLRKECRRKILRSRNQTVDLWLQQDREAGEDEANGDTFADLEDFLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP76</accession>
    <name>B7FP76_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_41667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176659.1">
        <property type="nucleotide sequence ID" value="XM_002176623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP76"/>
    <dbReference type="SMR" id="B7FP76"/>
    <dbReference type="FunCoup" id="B7FP76">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FP76"/>
    <dbReference type="PaxDb" id="2850-Phatr41667"/>
    <dbReference type="GeneID" id="7196102"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41667"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027518_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP76"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33985" checksum="CE90DDFA016896F6" modified="2009-02-10" version="1">MMGHFWAAREYLTPTLKTSAFLEKGVLTPDEFVRAGDELVFRCPTWSWQGNSRGSGSQASATKTYLPAGKQYLVTRNVPCQARVASMETAMDLQRGEDDEGDWLISNFIQHKERCIEDEFDILDETGEIMDVPKTATLEESDGNDEYADMADFEDDNVIRDDVATAVVVDRDDNLIKTRTYDLSITYDKYYQTPRVWMMGMSAEGQPLSGQEMMEDVISDYANKTVTIEAHPHVSGPHASIHPCQHGKVMKTIVRNLMQSSTDGDEGPSVEMYIFIFLKFVSSIIPTINYDFTMDVTASTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPG5</accession>
    <name>B7FPG5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="4">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_6934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176710.1">
        <property type="nucleotide sequence ID" value="XM_002176674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPG5"/>
    <dbReference type="STRING" id="556484.B7FPG5"/>
    <dbReference type="PaxDb" id="2850-Phatr6934"/>
    <dbReference type="GeneID" id="7196140"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6934"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278321_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPG5"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="121" mass="13580" checksum="2BD4D8F40FEFCF19" modified="2009-02-10" version="1" fragment="single">GTDFKAGQTKFKTAAVEYIRTMGLKPKVIASSNHLGNNDMRNLSTAKTAASAKLRVKHDIFSAWQEDDLDHKVSIMFTEFINDEKRDFVEYTSLGFLGQTHTMVTYTRASDSVLCVPLMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPJ5</accession>
    <name>B7FPJ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">APC3</name>
        <name evidence="4" type="ORF">PHATRDRAFT_9475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176724.1">
        <property type="nucleotide sequence ID" value="XM_002176688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPJ5"/>
    <dbReference type="STRING" id="556484.B7FPJ5"/>
    <dbReference type="PaxDb" id="2850-Phatr9475"/>
    <dbReference type="GeneID" id="7196156"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9475"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_1_1_1"/>
    <dbReference type="InParanoid" id="B7FPJ5"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38375" checksum="FE871733147734B5" modified="2009-02-10" version="1" fragment="single">VRHILELLCSMGKAYQCLRSYNCKEALQILQTLPLRQQATAWVLHQEGRAYLELNEFASAERCLEQMQIVDPGRMKGLELLSTVYWQVKKEVELAHLAQRVTDWDRESPEAWCVVGNCFSLQKDHETALTFFSRSLQLNPNFTYTHTLSGYEYMANEDFVKAIACFRQALRTDDKHYNAWYGLGAIYQRQEKFDLAEYHFGKAVALHPTSSALRCNLGIAQFSNGKAYQALDTLSEAFHLDPRNPQARFQRASIYMALHRPEEALSELCKVRDVAPREATVHFSLGKVYKKLGRTKEAMKCFLTAMDLDPKGSQTIKSALEKLEEPDIDEGTGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPN0</accession>
    <name>B7FPN0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_31898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176742.1">
        <property type="nucleotide sequence ID" value="XM_002176706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPN0"/>
    <dbReference type="STRING" id="556484.B7FPN0"/>
    <dbReference type="PaxDb" id="2850-Phatr31898"/>
    <dbReference type="GeneID" id="7196173"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31898"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269058_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPN0"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="251" mass="27793" checksum="658AC08C9046340B" modified="2009-02-10" version="1">MTINANKAVAHGAALQSAILSPRFKDANDEAQGMEVDAITGAQPTNAVVMFDRSLSFTIVRRMTLKRNQGTFAVLAEYNKKALEYGLLAFGNAIATFSVQAPISEEAKKICVNVKEDIHGIIQLSLAQLMEEIANKEESEMSDPSPLKDGEEDAAPENKKKVKKTNLVFTTTRPLDWTDGKIQKACQVELAMALKDKLVQGQTRARTVRQTLQTQGLYLRYAGQGWFGFGSGIVWYRRGKGRLYYPKRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPT4</accession>
    <name>B7FPT4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177270.1">
        <property type="nucleotide sequence ID" value="XM_002177234.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr42856"/>
    <dbReference type="GeneID" id="7196446"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42856"/>
    <dbReference type="eggNOG" id="ENOG502S7IM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280987_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPT4"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855257" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="150139" checksum="628F9D198E69F33B" modified="2009-02-10" version="1">MKTENGRKLNSWYVLFCFVSSTMAEYTYYDNEGYQEGYNTSHTITGGDGMEYYSNTSNSATNSSGGDIDYWTNYAIFPKRCIVYKKTDYIMYEMFDQQYCQEENRLGTYISRVPDYMTGHLQQLAEQMSDLGVDDYTKPEVAQYIECTPFQIQGAYYYFQIGCADGVTQKLAVNIYSDNTCSKKSTVDGFDDSVIDVSALNIPFKQCQTCVNWVNVDGADDQFYIKRQQNAPLCKTAWTYKKHCGRQCQSVGRNAEVEGWNASDKILISVLSSFALILLGSIAFRRQKMPNKDILLEQAFINSAGLRQSQIFVIIIIVMAVIAVLIMLGLKDATWALLLVLNTALFAYLMKLTLESSVNTGEIIIGPDGTILRKDSDDSSIESTSFVPSTDAIPRGPVDPFVLARSPLVSVIKLNKASCKENALVTPLLRSDHHHELSLQANSEASGHVAEADIEGEEVGGTSMSSTYHDPRFIRNPVIRGLLLRLLRMQSAADSLPHLVQMIVSNGKITTVSFVALYLVCLVLWLPFWLLALLVTEWGVYALSVAGGYFIGRCIIRMIAFPGASRKVSTDIEKEFAKYSVRMLQSGVQSFAEVASIMSANPNHPQRVSVLKGYTLPSLWSRAKTYRNRVLGVYLEVLLHIYQQAPESSTGAQRGFTKYGNNVLSGDIGNIAGLSAQAQNDGLGLIEQLKTVLALVDTLEEQAHTFLEGRAAVVTPNDLPEDARRTAQHLLARSQELTNFVSSLKPPSDSSNEDIEDESEEDLTVDAVRRKLERQHGSTREAIKKGIASVIPLLDPPPHNSIFSFDLQRGCMLSRYRGARQLWVRRPSGGMLDVLHFPARDRCADTQRNSKALLYCNPNAGLVEVAAGMSLVGGNVPSNEGNEQASDGSWVDFYTSVGIDVYVFNYAGYGRSFGSTTCLKGNSAIDSYTPGILPRLIRIIRSTFLTFTPNPDTLRDDGFAVAVHLLKEVGIKQLIIHGESIGGMAASSTARRVSHEPELQDKLALLICDRTFCNLEAVAQRLVGGWTGNAIRMLAPFWSTDVAGDFFATNCPKIVANDAADAIISNEASLKSGISLWKELHRGIASTKGIGWMTEAPLQYRMADWENVCVNDSKYVTAPGVLRSQAPTWPHDKHISVEEAFHFAACCKRIGKYAKAFRKGSEGGDLSGLHPGSRRALMEAWQSLACLDGLTGAPLGVAVKQGFDTTVAWLCSFLIFGAQSIVAVAERRTEGDVGLREQLAIVPSDFDSRPAGFAAAEEGGMVHPKPLPEVIESLLSFQESGDPSLRDLSHEFQFVVGVLKYLQGRLSASTSIEAAQKSRKLQVFKEGVGFLLNLHCGHNNPFSKEEQLQLKGLLDRAIGVKGGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ13</accession>
    <name>B7FQ13_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_8891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177312.1">
        <property type="nucleotide sequence ID" value="XM_002177276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ13"/>
    <dbReference type="STRING" id="556484.B7FQ13"/>
    <dbReference type="PaxDb" id="2850-Phatr8891"/>
    <dbReference type="GeneID" id="7196549"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8891"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_1_1"/>
    <dbReference type="InParanoid" id="B7FQ13"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="24338" checksum="067A02B2592FFFC9" modified="2009-02-10" version="1" fragment="single">MGYIDGDTFLTTESFDVCLRATAAWIRAVDLVAASSGSASMALTRPPGHHATKSVSNGFCIFNFGAAAALHVLQDPNKRVSVIDWDVHYGQGVADILENCPRARYVSIHQSPAFPYMGEKLTVEGKHENVYTIPMPPETSWTCGYEQLFEKAIHFACEPGKWEPDVVIVCAGYDALDSDDLASACLTAADFGKMTSRLYEHLANTRPDRMPSIVIGLEGGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQC6</accession>
    <name>B7FQC6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="6">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_43018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177377.1">
        <property type="nucleotide sequence ID" value="XM_002177341.1"/>
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    <dbReference type="AlphaFoldDB" id="B7FQC6"/>
    <dbReference type="STRING" id="556484.B7FQC6"/>
    <dbReference type="PaxDb" id="2850-Phatr43018"/>
    <dbReference type="GeneID" id="7196826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43018"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024722_3_1_1"/>
    <dbReference type="InParanoid" id="B7FQC6"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="426"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="509" mass="54956" checksum="A4CC272AA6E4A9DE" modified="2009-02-10" version="1">MVITGSFLELVVHQKTLVTRFWLRNGASSLKKSALLSSPVPGTQRMNGSSSRFLSYRIAIVGSGPSGCYTAKYLTSALEKQGIVGNHRVDVIERLPTPYGLVRYGVAPDHPEVKNVQNDFDQLFEKGVQFYGNVQVGRHVTVDELRQAYDAVVLAYGCESDRKLNLPGEDLDGVLSAREFVAWYNGHPDYVHIGQQVARALGSNDKTRNAFLDASVVVVGQGNVALDCARILAKGGNGLYETDMAAHALPVLAGGAKDVSIVGRRGHVQGAFTIKELRELVKLEEEGYGASFVVRNDELDLGTTAASLEELASASGRPKKRIDKLLRDTAAKESNSAAVRAVVCERTRLEGSAGQQVAVGTGETETIPAQLVLVSIGYKGMPLAGTEQWFIASRGLISNEHGRVSGAIDDLGGLYVSGWLKRGPNGIIGTNIADAKDTVASVVEDLAGTDAKKDAFCLDSMLRARAVNFIKWDGYQRIQQIENSRRRSVQQPREKITSIAELMEAAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQE4</accession>
    <name>B7FQE4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dsCYC4</name>
        <name evidence="3" type="ORF">PHATRDRAFT_43034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177388.1">
        <property type="nucleotide sequence ID" value="XM_002177352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQE4"/>
    <dbReference type="STRING" id="556484.B7FQE4"/>
    <dbReference type="PaxDb" id="2850-Phatr43034"/>
    <dbReference type="GeneID" id="7196837"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43034"/>
    <dbReference type="eggNOG" id="KOG0654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553756_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQE4"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="211"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="493" mass="55680" checksum="EE07AB2610AC7D9D" modified="2009-02-10" version="1">MTGPWEINFGEDHNSFLAASVDEISGRAKLGKSNKSQHQKNSHIFSAVSFLRRAVEFAPGAPSNFVRARSQTNSPLPERLFFSHSQHPIPLTTRPPGELWQIVPYGIQVSIFCRIRGNTTTGSTMMLKLTMNPRRRSKRHRSIPHRLRLPTNPTAMETGDDEEDREKDMLAENIGVIIKQEGAAKYSCVDYLSLTVWQQSVYQLMKKSKADPITHHANTMIDEYCREQIVEWSFRVVDYFRIDREVVALSMSFLDRFLATCRCDRTSFKLAATTTLHLAVKLLYPCKLADLGILSDLSRGEFDMHDVTEMESHILHALEWNLHPPTSAAFTSLFLDYFFATRAVHVSNADLDDIYDVSSFFCELAICDYFFVPTRASAISLSAILNSLEGMYGPDNRLSHAILEAALELQVCGSGLIDLSAARNRLWELYERSEECALHNDKPAQEDIRQHGSCTYIKKLSATASPVSVSKPCHSSTDFSRTSHSSALRNESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR10</accession>
    <name>B7FR10_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176964.1">
        <property type="nucleotide sequence ID" value="XM_002176928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR10"/>
    <dbReference type="STRING" id="556484.B7FR10"/>
    <dbReference type="PaxDb" id="2850-Phatr43218"/>
    <dbReference type="GeneID" id="7196945"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43218"/>
    <dbReference type="eggNOG" id="ENOG502S5F4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431181_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR10"/>
    <dbReference type="OMA" id="DTAHYRD"/>
    <dbReference type="OrthoDB" id="414322at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="635" mass="72644" checksum="5A90F4C5C5D06B6C" modified="2009-02-10" version="1">MHEWHALSLTSPVAKDLGQADQSTISVSNPEFPLPQGLSFHRCFVDQVTQQVLVKDIQTREFVWEGFDQRRRVQRYHLSDVETNPHDLDELPPESLLRLRDFLESATGLRPTHAAVEEFSIRKMKRSGEYASNHTVTTFESVQLPALDVDQDSGSYFVAQIPLLQSAVQHVNKPRRRQANCWELESNRHSTDIDMPARSLLIKRKDFLWNWRSQMMASETTTDLVLVVKLYTLPESRNEASHIADDDLFGYIPSPQDRIPKPPMPSLEEVLTIVITTSPIKSHPSTELLERTMETFVRAGTDFAYRCRKVIVCDGYRQDAADAKVTKKHTNPKQAMRNGIVNQNQAENYQAFKNALKEKCAAAPVDTVFQNCTVEELDSRHGYGFALRHALRECVTTPFVCVIQHDRTFMRPTPMTHVLNAMWHHPRIKYVGMSMRSNLLYRDIFLGKYGRAYLDELNACIERPPELLVDAAEYGPNSRSTELMDFATDKLRDNILALTETYRASAQAILEVEHRQTLTSLPTPGKHQMSLTPTLFWYDNIHVVDTAHYRDFIFHEPYQMVARGGFVEDKLSPVLKRTVERLGMRQGHARFGCYLLDDHAGMFFTGHLDGGSYMTAAAKETFVLAQTDKEEKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRB4</accession>
    <name>B7FRB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176515.1">
        <property type="nucleotide sequence ID" value="XM_002176479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRB4"/>
    <dbReference type="PaxDb" id="2850-Phatr31431"/>
    <dbReference type="GeneID" id="7196629"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31431"/>
    <dbReference type="eggNOG" id="ENOG502S9I4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740734_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRB4"/>
    <dbReference type="OMA" id="FASYFYL"/>
    <dbReference type="OrthoDB" id="43579at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="221"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="374" mass="41214" checksum="4410DE5C66335588" modified="2009-02-10" version="1">MSEGDSRRKIGAQVTAKACHVVHLSECARRYGALRTTKVVVGTVVEVNNTRKAPNNRVSTFITADFDIGGGSVKRSTLNIRSVKLFKPDQSTVPSSPAAPIPAVDNADTDLAVPEQEEGEAVLQETSPDEELEFPAQPMMEIGIAAGEQVAGPTAQVAMQVWGVEDASFVMAHETKWYADKQATLIDINGSVQSKQFGINTPIGDLLGPDSDIDGKYSRLQYFLLMFPPDQLSAMCQLTNVQLVQQNKHCMSTGELLRFFGILILATKFEFSSRSQLWSTTAPSKYIPAPAFGKTGMSRQRFDDLWRNIRWSNQCPERPEGMSSHTFRWQLVDDFVERYNNHRANTFKPSHLICVDESMSRWYGQGGGGGGGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS38</accession>
    <name>B7FS38_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_7718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177911.1">
        <property type="nucleotide sequence ID" value="XM_002177875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS38"/>
    <dbReference type="STRING" id="556484.B7FS38"/>
    <dbReference type="PaxDb" id="2850-Phatr7718"/>
    <dbReference type="GeneID" id="7197421"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7718"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1028410_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS38"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF57">
        <property type="entry name" value="PEPTIDE-METHIONINE (R)-S-OXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="134" mass="14461" checksum="AAE63CB98C00F628" modified="2009-02-10" version="1" fragment="single">AVQKTENEWKTQLSSMQYYVLRQGGTEAPGFSVLQGEKRPGVFECVACGTPLFDSQFKFNSGTGWPSFARGMPGIEVEQLNPVQASLGGAELRCGTCGGHLGDVFQDGFLFIGTEAQKSGQRYCIDGAALLFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS39</accession>
    <name>B7FS39_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177601.1">
        <property type="nucleotide sequence ID" value="XM_002177565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS39"/>
    <dbReference type="PaxDb" id="2850-Phatr32597"/>
    <dbReference type="GeneID" id="7197129"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32597"/>
    <dbReference type="eggNOG" id="ENOG502S4WB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095464_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS39"/>
    <dbReference type="OrthoDB" id="38535at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852565" evidence="2">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="20371" checksum="402869D50C61627F" modified="2009-02-10" version="1">MAHKLFLALLAFVTVLNASAFIAPARTRNPLSSVTVNAGYVPDGLTEEQYRKIKVSDAKKNKGKDLGRLGPTGFKSRSMQAWQEAFDQGKTGHSFAPLNYKEKMKKGLMKREDVPYMVRGGSWDNSDVKGAKKLKWSKEDKEYAKGGYKKEQSASILGSGPGFDWTGNGSKSALEKIKKNMPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS84</accession>
    <name>B7FS84_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177937.1">
        <property type="nucleotide sequence ID" value="XM_002177901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS84"/>
    <dbReference type="PaxDb" id="2850-Phatr32645"/>
    <dbReference type="GeneID" id="7197155"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32645"/>
    <dbReference type="eggNOG" id="ENOG502SZMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1153619_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS84"/>
    <dbReference type="OrthoDB" id="160518at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37067">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37067:SF3">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="241" mass="27623" checksum="5CDAAEEC04B15B20" modified="2009-02-10" version="1">MPSSASPYKRGLTFQPKHQLEYGLRITARSGPEGKASTVHCKFCHFFEREQVAGKKRRTIEHEKVFVTGCFIPFQYRQHLLTQHLTRWEAYKTLSISEKKVYFCADDPDVVDYEDEMPEEERAVTYNDLYPALPNVGMAGTENATANPGDDALLQASIADEKKRKRLFEVGALSVDHYARARVYRRQIEDERFRGGHSAPPWAVAMQNQLIGLTKKLGKRLDAMEERLEVIEDALQQTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM4</accession>
    <name>B7FSM4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178006.1">
        <property type="nucleotide sequence ID" value="XM_002177970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSM4"/>
    <dbReference type="PaxDb" id="2850-Phatr43555"/>
    <dbReference type="GeneID" id="7197585"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43555"/>
    <dbReference type="eggNOG" id="KOG4383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FSM4"/>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139791" checksum="92B3145DB8418129" modified="2009-02-10" version="1">MSRHIQDKSTIRPLSWVDARSRLRLLLKSYLQESTNISKKEETPEDSIREKESLLSQWVTRDLDLYCGALMLSTVIFILACFSLKERHDGVGEGPLEPGASLGVYRSQVTAGFFLVVGSIVSIWTVHRRRFLCQNDGENAKKREISKFLRAWECMEGKASADSAETNTGNIDIPLELAGTALTDIYPVYRRNGVRKASKASWKRIPSLLMAEGDLIALQIGDVAPADCVFVSNPEKQMEAGERITLQTFDQSLDDVISRLPKGRTTLEPDSEHLLSMCNKMQIFRVLKAPLAKFIRPSYGKSRPSQIVRQLKAIRKCLAVAAPVLLILTAGIVFSRPGIVSGNLSLILPLPLLASVGVLPVVGPAFMFFLEVLGTARILRTIHPFSSTSLDEKFQAESFFRSRLLLQYVVVTGLSRLSLWKYADRIVHFYRRFYPDRSGGSDVFKLVRVPPASINLLEKLGIATVFALVDDELACEPHAIPQQLLIPSGKGLKLLDLCPTFDEDSDDETGSARGRTVDSDSDSEGGESTFHSTLRRKVLRRPLLRARKAKQHDSENETDGTDATSLDVQFEDPLWWQFLPSLKCIGLSCLLMEKTKIPTEIPHTSTNPNADDYESCELDGAESALVKLLCTERRSYQFRSLAECIGFSTEPNALGSVGDISPFVERLRLHILSNGLFKERLKSDAHERSSGQSRWWGVIRPDSTSVIVEDKRSNAYQLLTVGDPLVVTNLCNEAWQGETSTILPLAAQDRNTILETSKNWKLADLDVAAFGYSPVPRTLESRLSQEKVQNPSYLLDCGQPGQSVLKGKSASEEWGLVRNQIFLGVLGSLVVPRREIHKLLSTLGDAGVRFVYFSPRNMRRQKELASQMGIDVAWNCAISLRALASGEEDPHRMVSNYADWDINAKLPHGVEDVRKHLKEVDNVPLLVSLFTDATKATTKDMVDIFQEYHETAITVGLSHLPWNNEIFSTADIAVGIDILTDITDTLPAAWGEGGEASMTRNHVLPSELEFVCAIASHSCAFRFQGASSLSHLPEILEQGRAALEAVTAAARVPPKNDQTVVFPSRNEGVRLYRTMLLKALLPAIFPQLMHLIVFGELMLEMEPALIEMRCPSASSWVDVVRCDSLEEYSGPARISAGVIVFALFVFCNIVVSTSFVRRFELITDYPPWRDNKIVIWALVIGVLITIVYVILAVDEAASGSQLPWYFYALSVLIPLPCLVWNEWCKREEAKQERRADKLRRLQFETRLGAWSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSU6</accession>
    <name>B7FSU6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_1341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178042.1">
        <property type="nucleotide sequence ID" value="XM_002178006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSU6"/>
    <dbReference type="SMR" id="B7FSU6"/>
    <dbReference type="STRING" id="556484.B7FSU6"/>
    <dbReference type="PaxDb" id="2850-Phatr1341"/>
    <dbReference type="GeneID" id="7197330"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1341"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="InParanoid" id="B7FSU6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="540" mass="58466" checksum="707A97702C83400B" modified="2009-02-10" version="1" fragment="single">YDYIICGGGLAGCVLAERLSQDESKRVLVLEAGGSDYKSLFIRIPAGVLRLFRSKYDWQHETGGEKGCNGRNVFLQRGKILGGSSCTNVCLHHRGSAEDYNSWNIPGWTATDVLPFFKQSQKDETGRDATFHGADGEWVMDEVRYQNPLSKLFLEVGEAAGLGTNDDFNNWSHPQDGVGRFQVSEVNGERCSGATAFLSKAAKRSNVIVRTGTMVRRIDFDETKTAKGITYDLMGDDTCTVPCLKEGGEVLVTGGAIASPQLLMCSGIGPGKHLRSLGIPVVHDNSAVGENLQDHPAAVVSFKTPQKGVSVTSKLRLFGKTNPIPVFQWLFFKSGLLTSTGCDHGAFVRTSDSLEQPDLQIRFLAARALGPDGMTTYTKFRTMKTVEDGYSFQSVACRAKSKGRIRLSSSNSHVKPMIDGGYLSNQDDLATLRAGIKLGRMLGNRPEWGEYLGQEVYPGPDVQTDEEIDEYIRNSLHTANALTGTCKMGTGRGAVVGPDLRVIGVNGVRVADSSVFPCIPGGQTATPTVMIADRAAVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT75</accession>
    <name>B7FT75_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178107.1">
        <property type="nucleotide sequence ID" value="XM_002178071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT75"/>
    <dbReference type="PaxDb" id="2850-Phatr43715"/>
    <dbReference type="GeneID" id="7197247"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43715"/>
    <dbReference type="HOGENOM" id="CLU_1411300_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT75"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="193" mass="21467" checksum="BA6FBB5C07CB85C4" modified="2009-02-10" version="1">MCIAQDRRQKSPKAIPLIPAVSKANHVSNVPSFHINSKQAMQRTESYDTNSTTLSKESHTSGAQNSANFVEDSKLGKGEKDLEFDAPGFAFLDIPVGGIIRLPRDRHAESLDHPAKTCLEIASRMFRLSHDEDTSETSEFDSKAHALLGGYRTPPVDVDRFQVVYPPATPQPCKVIHSEFQQIPENLLLPIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTK3</accession>
    <name>B7FTK3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_54217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178431.1">
        <property type="nucleotide sequence ID" value="XM_002178395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTK3"/>
    <dbReference type="PaxDb" id="2850-Phatr54217"/>
    <dbReference type="GeneID" id="7197953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54217"/>
    <dbReference type="HOGENOM" id="CLU_1096072_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTK3"/>
    <dbReference type="OrthoDB" id="47315at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="254" mass="28633" checksum="7553D4A0B3BBF9B0" modified="2009-02-10" version="1">MQASKRVRFPDDDQHGPLSILLCTVPHREDFSKEEQENLYFSRGDYHMSRSAAKVVSKESERLGYSKTLRAVFQEKSKEAQDSLNLWAASGHSRRGLERWANKEHGEIRQREQFNAVMAVLRAQDDMLCNKGQVSGEALRKVSYKATKTSRHFARMMGKADSYAVAATLKGSDDGSLATAITFLTMQSEEDNVSKRSLSWDDQSVDVTITGGDELKDSCHGDRRSGSRLRRFGFGRKQREPKVPATEPRVSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTY6</accession>
    <name>B7FTY6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FABFb</name>
        <name evidence="12" type="ORF">PHATRDRAFT_18940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178506.1">
        <property type="nucleotide sequence ID" value="XM_002178470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTY6"/>
    <dbReference type="STRING" id="556484.B7FTY6"/>
    <dbReference type="PaxDb" id="2850-Phatr18940"/>
    <dbReference type="GeneID" id="7198057"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18940"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="B7FTY6"/>
    <dbReference type="OMA" id="DVMVCGA"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000018">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="13"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="457" mass="48683" checksum="8ECB5A3D9D97757A" modified="2009-02-10" version="1">MASPLSAAASLRSCRVVVTGIGAITPLGNTFAESWQSLLRKETGVTSLTEALSWQGLSSEELLHRELTVAATLPCQVASPVRWQHKDSRTNRFVQLALVAGREAMLESGLDKWIQAGEGQIDRSTTDNPRRHRIGACIGSGMSGVREIAQAVNSMETSGFRKLSPHFVPKVLSNSAAGRLSIEFGLQGPNHSASTACAAGSHAIGDAFRCIQYGNADVMLAGGAESCIDPLSMAGFCRLRALSTAYNDTPEKASRPFDRDRDGFVMGEGAAILVLERLEHALARGAPILAELSGYGLTGDAYHVTAPDPLGCGAQRAIQMALDQSFGDRRYVEEMPVGYVNAHATSTPKGDEIEARVIHDVFRDSSPNLIVSGTKGATGHLLGAAGAIEAAFTVQALNTRQIPPTLNLHETDAETEHFGFQHARDTMHVPTLQVALSNSFGFGGTNASLLFKRISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU23</accession>
    <name>B7FU23_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_33857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178239.1">
        <property type="nucleotide sequence ID" value="XM_002178203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU23"/>
    <dbReference type="PaxDb" id="2850-Phatr33857"/>
    <dbReference type="GeneID" id="7197882"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33857"/>
    <dbReference type="eggNOG" id="ENOG502SSA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260969_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU23"/>
    <dbReference type="OrthoDB" id="43720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852641" evidence="3">
        <location>
            <begin position="23"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="601" mass="66853" checksum="C4481ABCAB293786" modified="2009-02-10" version="1">MANPTPLRQSILLAWLVLNGRAAVLRNAKTKEHLLRAEFLQAMQQADVERHLERARSSLNDELLTAATKVQSSRDLANNYEDGSNSMSSSNQESSLDLTKLALKYVGCQNIHTFSDSQASNSSAKSPFLLNRFVILRLCTSTSCSSFNKLGCNSNYGEYTLPMDDYLQIMATYHFRQFDQYCEICTECMSFDSSGSGSTDSNSSQNEYDDDTYVDDLYSTDDAGAAKDDDSVYGDDDRDGTDESYNYYSNGAQEDDWEGYNRYWDGGNRQLGNGYNQYTGDYHNGYYSSNGSGEYSNYNNYPWYINSSGKCSFKSVCSSYANVCKSYSAYSVSHEKYFQCTAFQVASGTVHLGPHCEQDGHAIGMGIYSDGECSNYIGDIAHLNKYTGTTFDNIDMSAYYDNTCISCSASEGYGLVTDDAIATNEFTYPLCNVLYEYSAKCNRHISSQSTYGSKEASQESDEDAVCTFITSLVENNYNEHGEAIVGSGFQLSHWNRPQEYSKIIQRASSLQVFGLFLSIGAVLGLATYCFYLTKKLKYRKPWQPPTRVAASYNGGRMWIDARSEAGRISRINSGVVMMRSRSKSPPRESGALVCKGSSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV02</accession>
    <name>B7FV02_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178685.1">
        <property type="nucleotide sequence ID" value="XM_002178649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV02"/>
    <dbReference type="PaxDb" id="2850-Phatr44709"/>
    <dbReference type="GeneID" id="7197934"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44709"/>
    <dbReference type="eggNOG" id="ENOG502QRHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493928_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV02"/>
    <dbReference type="OMA" id="YCDFVVR"/>
    <dbReference type="OrthoDB" id="2015991at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="60800" checksum="34F1CAB406B0CC02" modified="2009-02-10" version="1">MIRRRPTTNDANSYKADDDKLGKQLLFTTSSQQHSTQTPKPMVSNLVVCIIVIVFVGAGVVQNRYQESHNDFHSGSGTDKTVAQSSQRRKTSFLQQSLLTPEEDERLQTDERGNRYHLVFSTDCSPYQHWQSFLVYYTALKVRQPGQVTRIASGCDPEQAKAMQRWFDQDVQFMSKRYHLQMTPHFSGVKNEAGETVADYKFFNKPFGFLYWLEHSPQLHYSASHSEFPKDFQNDIVILIDPDMGLLRPITADFSDERETVVSPRRREHGVLATNVGPGHPFAQVYGFGTQWARLDLEKIAGAGSQARNISKEDGQLFYPVGPPYIGTISDMHRIALKWTAFVPRVYEQYPHLLAEMFAFCIAAADEELPFQLIDSLMISKTDASGEGWPLVDRIPPDEVCDFASDLDPSKYAVPSVVHLCQRYWLGKDWFFSKRKIPSDIYDCETPLFEEPPSDLGVLYDYKWAWNGRKQMVTPTEANREAFLLCFLFRLLNDAATFYKQNTCPPDSINLEKSRNLVAYLKAKSRHTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVH1</accession>
    <name>B7FVH1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178930.1">
        <property type="nucleotide sequence ID" value="XM_002178894.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr44743"/>
    <dbReference type="GeneID" id="7199718"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44743"/>
    <dbReference type="eggNOG" id="ENOG502SH9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256100_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVH1"/>
    <dbReference type="OrthoDB" id="49087at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150713" checksum="951B9C4F5B4F1CC6" modified="2009-02-10" version="1">MEKSQVGKISFRLALSRQVSSSCQAGRKRKTPTSVNETNAEAKTLQAAHDTNSVAIVGWIFTPLNSSQEYLLSVSMTLAKKTCDAARFQQTVRLDRYVQFFLEAQPASAEHPDPMNVVLLEVPDDALSIVDPGSPCNTFFDSAIDVWTLQQTRRLEVMNRQENVASSRTDAYTIRAKVHAVSPIIAMDTSNPFVLMELFDYHDDESILSCVAVIRHDALLCVEALYPGDDLVLHKVLRQQWRIPDMLEAKGYRWGQKIRVNSYVYVVDKECQIIWCQSNPDHVHMNRLPTTELRNIQGCIQSVHYTKTGSQIHIQFLTLTNIMDVASNPSTSKCLVLLLTYFPMSSALQLSLREGASVEVYNVHAIDNDQTYAACLRSKICLRRLAIDGPAPGAKIPPTMKKENCRGKGLPLPIPYSFLKIRRSYHEWVLRIRLENWLSQARWRVPIGCRMPFLDELISFWFPESFPQKRPARNPYAEFFDHAFLEYPCEKRTKPQPIYGCHLSTNTKPFSMPSFLDLAAIQTHAFNALSSKLDRLFEIGTDLQVGWHAAFVLEPWDLSSNSQPFSKGEHVYTSGFGHGKHHNNFTSLSLTTGGVILPVSGLCINADVRTLAAATEFFIGRLRSIVVSCLCVGFSSNDSRSDRHCRKVLLPPPESEQNNATGCCAILEIQGLLLIASFCLDCDEMRTINSGCSVFDANDEPIGTEHSVRDLLDPLSAKSQVPGSAVGLLVRKSMKLAKIRNCEFNGLMLTLSQAPLISSIDEFSCIQSIEIKPPVRVNESWRIQIRRWITSGLGATVTEDQLSLILVWWTLASSASTCALLSGGWDEFQGISAPSIASTCGVLVRFPSASAQQDAKRGYVRLRCAVDDLSASFFFPISNAAPTDANLSEDAFHFSGGERFLTGMLNRRVTRTRSHLASSEDETRLLPILGDLLLPPTASEIPSCTLADLHLAICRDLRQPGSAHLAPSLVREIRNATFLSVSYCSAQAQCSKCFQTLVNPSANGDGQKEKKGDEGNGLVRTLSRNLDREGVIGPSYWDRPLPNEPMVCPAIPPTSPPISAPRPQVNSREGTHLRCPNNCNVNYHGSIKWECSGVLDDGTGQAKLYAEREAALSLLGMSAIAMQAVEAGAWVSDRGIVFVKTAPPAPHIRSAVVMARSLAREALRLRSGGRHHRVVLQESDVLPYLTPSTQAAYCLERHGRSSVLPLREVSYLVRCKPLSDHVSHLNHTEVDLAVPGPDGSRASRPTPSYALPPLKLTLVDTCDTVGCLRPYINLGVSARTLRPIRKLLLGLHKLFEIFCGSEAHAFFGVNVDGCSRAGIAAGPFLGTHGGEDTKLGYRYGLALGQCLQQEDRISERQKICMGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVY1</accession>
    <name>B7FVY1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_34403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178785.1">
        <property type="nucleotide sequence ID" value="XM_002178749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVY1"/>
    <dbReference type="STRING" id="556484.B7FVY1"/>
    <dbReference type="PaxDb" id="2850-Phatr34403"/>
    <dbReference type="GeneID" id="7199799"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34403"/>
    <dbReference type="eggNOG" id="ENOG502S79E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1196866_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVY1"/>
    <dbReference type="OMA" id="NIKRVCC"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14494">
        <property type="entry name" value="PTP_DSP_cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022778">
        <property type="entry name" value="CDKN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05706">
        <property type="entry name" value="CDKN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="232" mass="25820" checksum="BEE285E70D74A2D5" modified="2009-02-10" version="1">MTRPSANTCCPGNSASCPQLEDGTKCESDLPATAPAQQQLECDSHSLILVQKNDTIRTKGLARHNFGPASSRDCIVFTSERPGNPACKMNPISVEATQPWIEFMLRKGITNVLVLLDPWELETYTEMSLENIYKQAEIKCFFEPMKEEGACDRIFQILYDAEQRGEKIVAHCTGGCGRSGRIAAGWIIYRYGVSVEEATDEVVRCAIRNSVCRKGNCYMLAEWLNAPHLNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWL5</accession>
    <name>B7FWL5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2254 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179403.1">
        <property type="nucleotide sequence ID" value="XM_002179367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWL5"/>
    <dbReference type="PaxDb" id="2850-Phatr45143"/>
    <dbReference type="GeneID" id="7200328"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45143"/>
    <dbReference type="eggNOG" id="ENOG502SWVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032303_1_1_1"/>
    <dbReference type="InParanoid" id="B7FWL5"/>
    <dbReference type="OrthoDB" id="205122at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018723">
        <property type="entry name" value="DUF2254_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10011">
        <property type="entry name" value="DUF2254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51113" checksum="B2F2E6B392D6E085" modified="2009-02-10" version="1">MHTLLQHFCEQLKASVWSAPAGCVVLAIVLSQFTLFLDDRYTQDASGWFFITNSQGMSDLLSTIATSSLSLAGLSFSSIMVTMTLASGQFGPRLLRNFMKDRTSGYTLGTLMGTYTYCLFIIRGPPVEEVDDKPFAPQISAFVATVLALLSLGIFIRFVQHTLLIIQAENVVADAHLGLLETIRNVFPNPDDGKVQERIHDPDDDEGWPIKSGRSGYVQAIDKMSLVQIASSESAKLYLWVRAGDFISSAETIVRVIEGEPEEKLTKETIQRIQQCIYVGRNRTSEQDYEYGIRQLVEVALRALSPGINDPYTAIDCIDYLGSGLQTIFERQLPQSVYRDAEDSIRVIWHVTDYEGLVCAAVDQIRQSARTNCAVSCHLLKMLKTTALVSDREDQRRALLRQATMVKRDTTPAMFNDHDKNAIETRYKAVVKACRLPDPEDTKSDVKSNKKTREATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWQ7</accession>
    <name>B7FWQ7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_3046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179421.1">
        <property type="nucleotide sequence ID" value="XM_002179385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWQ7"/>
    <dbReference type="SMR" id="B7FWQ7"/>
    <dbReference type="STRING" id="556484.B7FWQ7"/>
    <dbReference type="PaxDb" id="2850-Phatr3046"/>
    <dbReference type="GeneID" id="7200352"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3046"/>
    <dbReference type="eggNOG" id="KOG2718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034788_1_2_1"/>
    <dbReference type="InParanoid" id="B7FWQ7"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF30">
        <property type="entry name" value="SODIUM_METABOLITE COTRANSPORTER BASS6, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="33101" checksum="165B6ADBA927D1F5" modified="2009-02-10" version="1" fragment="single">YEKTANVATTLFPLWTVLFTGLALKSPSSFAWFTTEYFTAGLAALMLSMGITLTPNDFKKVAARPNATLMQFALCYGMMPMLALGLGKAFALEPALIAGMVLVGSINGGQASNLCTYIARGNVALSVLMTTATTLGAIVMTPLLCKSLLGAVVPVDAAGIAKSTIQVVLAPIVIGMTTNKFFPRFVEKILPFAPVVGVVSTCLLVASAVAQVAEPILNAGLRLQIPIMLIHLLGGLVGYILPRLTGFGETSARTMAIETSMKSSAFGFLLAKLHFGDYAARVPSAVSVVWMALIGSLLAVVWRYIPVETTGKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX43</accession>
    <name>B7FX43_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179273.1">
        <property type="nucleotide sequence ID" value="XM_002179237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX43"/>
    <dbReference type="STRING" id="556484.B7FX43"/>
    <dbReference type="PaxDb" id="2850-Phatr45279"/>
    <dbReference type="GeneID" id="7199936"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45279"/>
    <dbReference type="eggNOG" id="ENOG502RRBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1158320_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX43"/>
    <dbReference type="OMA" id="AHIGVEY"/>
    <dbReference type="OrthoDB" id="311468at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="240" mass="26203" checksum="11FEFAC438231143" modified="2009-02-10" version="1">MGRGALLFKGDSKTKKKKSKSKHTPKTTPDVHCTLSIGEGNTTSAVSASSSTSTTVTKQELSRSSMNGEDEPTPAASTPNIVTGTGKITSSGTVVTGYGTRFTKEIGVGDALLVSMTDKKGQQQQEMRVVTMRLSDVSLNLSSSFSESIRQPTEFQYIPKPRNVAKESRMAKERALQSKHEEAILAFGTYGSTNTEELVYREKTEHGSYRIKRVQVQGSGKVTRGDLLDLRSKKKHDKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX45</accession>
    <name>B7FX45_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179490.1">
        <property type="nucleotide sequence ID" value="XM_002179454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX45"/>
    <dbReference type="PaxDb" id="2850-Phatr45280"/>
    <dbReference type="GeneID" id="7200144"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45280"/>
    <dbReference type="HOGENOM" id="CLU_1558259_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX45"/>
    <dbReference type="OrthoDB" id="54209at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="172" mass="18652" checksum="83E3FC1D8D6E2473" modified="2009-02-10" version="1">MVEVDYGYGDATPETDYGYGDGAPETDYGYGDAAPQTNYGYGSAKPDTDYGYGDAKPDTDYGYGDAAGTDYGYGTEEPAGNSERQPVKRRCSVTKYSLQTAQPPVSETEQQAQRTPQSDEKSTARTAASSCASSTDGMDHHSSLHKNDVVHKKHHPKTGMLKKIRKRLSIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXL5</accession>
    <name>B7FXL5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179576.1">
        <property type="nucleotide sequence ID" value="XM_002179540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXL5"/>
    <dbReference type="PaxDb" id="2850-Phatr45413"/>
    <dbReference type="GeneID" id="7200505"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45413"/>
    <dbReference type="HOGENOM" id="CLU_116159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXL5"/>
    <dbReference type="OrthoDB" id="41610at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20135" checksum="8EC34D87118C0C39" modified="2009-02-10" version="1">MLRSVFSGTWHWQWTARRLQTLMNWYPPFVGAGVKVVTLANDFRYAKVQMPLTWYNRNIVGVHFGGSLYAMCDPVYMLLLMHALNDTNRHGPHEFVVWDQAASIQYLQPGRGTVTAEFILNDALLQRIQTMEPGTKQTLDLGVDVRDEAGNVVARLVKTEYIRRLRMPLRPNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM1</accession>
    <name>B7FXM1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_56510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179580.1">
        <property type="nucleotide sequence ID" value="XM_002179544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM1"/>
    <dbReference type="STRING" id="556484.B7FXM1"/>
    <dbReference type="PaxDb" id="2850-Phatr45418"/>
    <dbReference type="GeneID" id="7200536"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56510"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436473_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXM1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852789" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="664" mass="75681" checksum="48DC2FBA10BCEFB9" modified="2009-02-10" version="1">MHWTPLLLIRSVTFLSKALVESREYTFVQESHFISAIMNDRVTAHASSSGTIPKRTHKKQQAPTNVDPKKWIRGVNLGGWLVLERYITPYQFAITSCHIQGDLCWYEGQLSAPPTDHPDYKLCPAINAIPKTNNTETTIERETCEPILSTSVFDELDYPIDEWTLAQAFTDRSIGEKWLNFHFDNFISRSDLVALRNAGLSHLRVPLPHWILQQRQDPRSASSNHTDWDVDEDVWIAGDRWKYFVRMCGWARELGLEVWPDIHTAPGSQNGFDNSGVQKVEHSCQPWSSNPAHVERSLRSIRDVVRGVVEEGLSDVVTGFGLLNEPFLDCDFDVYKKFMEDGLDIVRDGLGKETAVFVHDQFSASKYNDGSWWLPQQGSNLESEGLQHQRYQNTYLDSHYYQVFAEQFRALSPRQHIAFTCQGETHKDGAASCCYSDPPHNRQPSLSQGKGVQRLVSEWSCATDTLVVDMLRLVMKAIRRNGTAAFSDRIISPERMAFLNNFAQAQMVVYETANVGVSGGWFYWTAKMEGGAFAEWDFLRGVREGWIPKLPSKENSSQAVFGTCQEIIFRTDDDMDIIHEYPPREEDPPAWQLDDDVVISHGESLLENGPWHAIARIHFHWIAVAIVACSALVVLRLCVKRGKRHSYEKIDSNGFSLHKTREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY79</accession>
    <name>B7FY79_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_3137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179688.1">
        <property type="nucleotide sequence ID" value="XM_002179652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY79"/>
    <dbReference type="STRING" id="556484.B7FY79"/>
    <dbReference type="PaxDb" id="2850-Phatr3137"/>
    <dbReference type="GeneID" id="7200379"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3137"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022783_1_0_1"/>
    <dbReference type="InParanoid" id="B7FY79"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="167"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44517" checksum="E4F871AE962653E7" modified="2009-02-10" version="1" fragment="single">VSDPVQHADGLNKYTSYRVDVRPPSATPGEVPQDVHLMNNTYSAVLRRYSDFLWLYERLHHERAGAIVPPVPDKQPVGRFSPAFVEDRRVQLERFLRRVATHPELADSTCLDTFLRADDVIFQAAKHAKTGTVLASHSQSMMMVMAPNAVSPNKKDGLKRWFAEAKTSMTGDLVRSPDDDLFEEIQRYIHGLDNQMRNVSHQASGLVRKGKEIANGMFEFGLAFNLLGQSEADALGDALSKMGQTADRLSVLSAEHAEKEMAQFEEPLQDYIKTIHAVKLALQRRHEKRLTYSTCCSEVDSKQTSLSKLRAQIGQESKAYTTEMSMRRAQEAAEAAREDFAATSQRVLREVDRFKREKAEDMRRTVLDYIALQVDYNKRMEEVWANLIPQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYB0</accession>
    <name>B7FYB0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="3">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_45621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the globin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="3"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179706.1">
        <property type="nucleotide sequence ID" value="XM_002179670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYB0"/>
    <dbReference type="SMR" id="B7FYB0"/>
    <dbReference type="STRING" id="556484.B7FYB0"/>
    <dbReference type="PaxDb" id="2850-Phatr45621"/>
    <dbReference type="GeneID" id="7200392"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45621"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="B7FYB0"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="13">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="166"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC48692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="426" mass="47295" checksum="0029B181AB4281BE" modified="2009-02-10" version="1">MSSIISDESFQLVRATAPVVAEHIEEITGTFYPKMLGRHPELYQFFNESNQRAVPGLCPAASGVVTTRQSKTLGDAVVQYALNIDKLENLNEAVLRIAHKHCALGVKAEHYQIVHDNLMEAIGEVLGSAVTPEVAAAWSEAVMALGKIFIEQEQKLYNEAEKVQWSGPKEFIITDIIDETPVVKSFRMKSKDGQKVCPFKPGQYLSIYEQPNNKKYFAPRHYTITSQPEDDFYQITIKKLIDPAVPDDRTHDGILSHYLHSKNVNDVIKLGPIFGPEVLLQGEKSRVAAFISVGIGITPTMGILPTAVKERPRTAVFHGDVNGSNHVSREALEEFGNEQSLFSYSYFNPDEADTKLQHYSEGLLTGSKIVDKLKDAGVNFATGTDYFICAGPTVAPILVNELRELGVDKKLLHLEFFGPFVSLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYL1</accession>
    <name>B7FYL1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179761.1">
        <property type="nucleotide sequence ID" value="XM_002179725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYL1"/>
    <dbReference type="PaxDb" id="2850-Phatr45706"/>
    <dbReference type="GeneID" id="7200477"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45706"/>
    <dbReference type="eggNOG" id="ENOG502SZ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514371_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYL1"/>
    <dbReference type="OrthoDB" id="48284at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="417" mass="46655" checksum="3EF0586161839B66" modified="2009-02-10" version="1" fragment="single">MNSYAVTAAFDAEEARRNARAASQVALRFQKEGFATTDQDPILKNLGISLPGHTTTDVTLASLAHSSTADSDFYRSDSPRKRKNISFPPTQTQFSNGTVNGNGQPAQTHDEDMGSLSLQLERSKQNLQCERRLHDETKSALTQAYFQNSKLQKQIECLLKDLESQRESSLHKTETLEEELERSHVRIQAAEEDAQLALDLAKSNSESREQLESWLQRALQEIEYLRESLTLPHDDRESPSPKHVRFANTPSIKLYSPSPDRPLATHHHDMVGKSARSVISAGRKVLRRSSLYQDTEDEIARKSMERRQQLRKKLLAPTSSDHTSKDAPPFSPPHSSTASTMAPVATTLANTTPFLVSAEDRLNEMARTATKIICSSGRRMSLNGRWWNTENKDSDLSSTVPDVPLDALTKHYCSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZI2</accession>
    <name>B7FZI2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180152.1">
        <property type="nucleotide sequence ID" value="XM_002180116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZI2"/>
    <dbReference type="PaxDb" id="2850-Phatr46013"/>
    <dbReference type="GeneID" id="7200869"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46013"/>
    <dbReference type="eggNOG" id="ENOG502T2IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373634_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZI2"/>
    <dbReference type="OrthoDB" id="513629at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="450"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="744" mass="83339" checksum="7F37DA77A6F21F01" modified="2009-02-10" version="1">MNRSPEDSFDQATADRDAERLRIDALERTMSFSSLLAVFEHPLSANLKAETGESTSGVGGGIVVTGVSGTTSLLAKKLARKTELEIVKESPTKPIPPIEVDFYRNPTILSRLILNQKYEAAIRRLHKNPEEAHVWVCAKRKPSKGDIPNSQIPFSLRQLPVHIAICNLQRCRGQACRDILNLLITNLVVVNPDSCRFVDHLGKLPLHLAIADGATPETISVMLMAHPASTESRDKQGRTMIALNQNRSLDDGRDQVHQVLSLGVDFWNEAHQEAVLRLKHAAPSLPSKDDKSVDSVSVMASSKAEEETLLSSVEQNRDPEPLPLLRQEGVEAIAWEQLEERAIALEEILAEVNERNYALNIRLDAVAKSKKELLDKLDEVHGDELVSDISQLEKQNLELQAKVIKMERLIRSSVIRQDLGGDGRKRRRQHEPNRSFHPLLDGAQKGDLASDDLALQNRRLRQAYEDLNAMYDKQQERLDRLEVIIETLTSEADEDYDDYSYHPSSNSVWSDLSAPSERILLERQAMRNVVQSHPAFDITWVPPQILVAESDDLSVIFQEAAIQESLLLARRDNRNRPQAWAPKFSTTNMTAATKSFRSNRDSIDQKQMKDLEIPVLHDSPHSSMSDSKRSDNARLKRAGFDTKISRSRGRSPRRAQELAVGEEAFANASVAQDSIGYDSSIYGSSMHLSMHESIYSEAGDMNELEIPALNTSTSNSVYEPIDRINLSRIGLFEDDDSEIVEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZN1</accession>
    <name>B7FZN1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179976.1">
        <property type="nucleotide sequence ID" value="XM_002179940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZN1"/>
    <dbReference type="PaxDb" id="2850-Phatr45741"/>
    <dbReference type="GeneID" id="7200892"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45741"/>
    <dbReference type="eggNOG" id="ENOG502QT92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360369_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZN1"/>
    <dbReference type="OMA" id="YEARFAV"/>
    <dbReference type="OrthoDB" id="206869at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35482">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35482:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="777" mass="86857" checksum="D2F06C4DA48F676F" modified="2009-02-10" version="1">MRSIRTRLTFEGRPSCQWTKVKFGTLLLVSLLWDGLVSLTRTFHNGSISTTTNHRLPLLVQAYVSVPLKPRTRRDEAFPSSTTTPPPRIPCSLSAQPNPREAEIRRKIAQLRRQGKLRKQQQPSEWDLDDDLDGDGNTSTENETAPQTSPRDTYATKVRDRLGPTKSKLLGFVDDNESASDSKSDELTVSSSSSSSSTSGRVQIGTLEPSQFDDERSSSEKYQRANMESTQSPNWIDPSLFDEDEDTQYEADQDEESLIDLVAEKMMEQQLREKSEKDRALMEETRARLQALELERRVETAEPPLSSTSVTQLTSGVGGSWDRNETAATQDVYQPKMGSWGAFPRPRDISKAYGGGRRIGPGFSNEQARVESTAATRERLQRYREKVGIEVESEKLHADEIAEALRIGSLAMERGIYSTAVSALEKVTRYCSSNSKVGSKVFLELAMAYEAVGRTEEAIAVYTTLSKCRMEDIKHNAKRLLYGLEAMQFMQKNVKSSEFSRKRAKNVFVDTTGLANIAEAFDDKYNMAYLDLEKGNYYKKLTEAVVRSPREARQILLKAVGAGEVPRLRIVQALRSLARQFDDLLQAEIESSTIQEPVAIMDGKPILKRRVEEKGDVKTMIAGMDDFLLGTPEQMMTNIDGEWRLQLLADKQGDGVKFFNNTVSWQQVDIKKMSFRASSSAGLVTIQQAGEVSFNEKRRVLRRTSVQVSGGGVFTGLFGGMNTGAPAAVSLPRQIITVDSTLLITRGVPSKLGRGKDDERDYFAVWRRVESGTFSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G032</accession>
    <name>B7G032_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin homology 2 containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_54518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180608.1">
        <property type="nucleotide sequence ID" value="XM_002180572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G032"/>
    <dbReference type="STRING" id="556484.B7G032"/>
    <dbReference type="PaxDb" id="2850-Phatr54518"/>
    <dbReference type="GeneID" id="7201444"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54518"/>
    <dbReference type="eggNOG" id="ENOG502S1HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304120_0_0_1"/>
    <dbReference type="InParanoid" id="B7G032"/>
    <dbReference type="OrthoDB" id="196074at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733:SF34">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="570"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112899" checksum="9F9C761AF852FCE0" modified="2009-02-10" version="1">MRLYNANTCTPAVTSSGTRSCFQRSEPRIQSLAVKVNNKPPPTTTQLDTQSLKLEAPTQRKVKEKFQSPIPSSHDEYHITRNPPHFLSRNTTADTSVSSGTFCGIFNRNSSRSFHFDVDGATCNDLDERCRGASSPFPSDFSASTLTTVSAFETYQDLLEKGHPPYQPIESAVSSSVEKSCLGQELIWPSPCRVRPRPRLSDVEPKDFGIEEIENVAARAKPNPDHKTPSQWKLHENCAFLPRNLAASVPEPKRTQSKKWNTFGASRRSNVDANNDMPDPQCLTPLTWVPFVTRFESSPASIEDSISTLFEPIEFPKDAPSKSMIVASPKPKGYFSKDRGRGVSGRDSFKGHRQKLHASDADSQTLEKAEDGILSRERIGGKVFQRIPGLSKCAKMTTPQIYSNRKYIAASSGYSETTGTFSVLDEQLHSPDLGAASLEQIFQKERLRKFQTNGKEMKQFKGKVDVEQKHSEIVVNLENQPTNYAHKSAFSATKKAVKAVPSSDDLEKANMLDLTNKGPSDKMIPDLPEKYTKMLKVGLSRAATENSMRRDGIDPDDFRPPETTSSKLLPTVAAKDPFRRFRIHWEAHTNVRSNTVWAMIGRDDQWLLNLAIDHDEMFTLFSETRDSAPHTRKPGQRKNNANAVKVIDSKRAKNGGIILARIRMSYKEIVRAIDSMDETALTLEQIKGIGFLVPTLEEREALKRHIERSGEELTTECEKFMSEIISVEDPARNLEAMLFMKKFPFCVLELKNGKKDEVKGHRWQPRLLNVSSRFTDAKTIQKVCDEILGASKLRRVLGVILRLGNELNQADVAAPKGAVDAVTVKSLSKLNQDKAFDQKMTFLQYAAQIIRENNEELLLFKDDMPSLKLAEKISWEESMQNVESIENSLTRLRKIALGRAEDDSAEKERGELPTENEFRVLQRTSIGRFIFNSYVEINSMYKEIEAAKSAFESLLNYFGEEATEPEVQHFLHFLFEFCNDFENAAERAVDKGNHYAKSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G081</accession>
    <name>B7G081_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_12562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180632.1">
        <property type="nucleotide sequence ID" value="XM_002180596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G081"/>
    <dbReference type="STRING" id="556484.B7G081"/>
    <dbReference type="PaxDb" id="2850-Phatr12562"/>
    <dbReference type="GeneID" id="7201241"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12562"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_1_0_1"/>
    <dbReference type="InParanoid" id="B7G081"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="49"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="384" mass="44271" checksum="9BC4866FEF16328D" modified="2009-02-10" version="1" fragment="single">LDFDVKRQWFKTQMRRLRQQASRRHGSLRLQIRRKYVFEDAYHQLRLRNADEMRGRLQITFRNEEGVDAGGLSREFFAILAKEIFNPNYALFTSTEDGCTFQPNPNSSINPDHLSYFRFVGRIVGKAVSDGYLLDAHFTRSLYKHMLGLKPTHHDMEAIDPDYYKNLKTILEYNLADIGLDLTFSIDDHSFGRSQVIDLISDGRSVAVTETNKEEYVRMVCQHRMTTAIQSQIKAYLDGFYELVDVDHIAIFTARELELLISGLPDIDVFDLKKNTDYVGWKATENEIEWFWNIMMSLSRNEKATFLQFVTGSSKVPLSGFSELQGMRGIQKFSIHKVGRPMGSLMSAHTCFNSLDLPPYSSEEEMREKFLLAINEGASGFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G087</accession>
    <name>B7G087_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precursor of protein violaxanthin deepoxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VDL1</name>
        <name evidence="4" type="ORF">PHATRDRAFT_46155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180635.1">
        <property type="nucleotide sequence ID" value="XM_002180599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G087"/>
    <dbReference type="SMR" id="B7G087"/>
    <dbReference type="STRING" id="556484.B7G087"/>
    <dbReference type="PaxDb" id="2850-Phatr36048"/>
    <dbReference type="GeneID" id="7201244"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46155"/>
    <dbReference type="eggNOG" id="ENOG502RY6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523270_0_0_1"/>
    <dbReference type="InParanoid" id="B7G087"/>
    <dbReference type="OrthoDB" id="10258187at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010028">
        <property type="term" value="P:xanthophyll cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044682">
        <property type="entry name" value="VDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010788">
        <property type="entry name" value="VDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970:SF1">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07137">
        <property type="entry name" value="VDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855561" evidence="2">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="VDE lipocalin" evidence="3">
        <location>
            <begin position="136"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="48694" checksum="2758259E7340926F" modified="2009-02-10" version="1">MRFAWVVAAGVVLTTTTQALVPLDCTGMGETRTSGIRPIRGLESNMARYATVRHGTDQTNHGITSSSERQWPFPRGGSSPRAVARSVATFGLGFSIALASVFGVAAAPVGADTTPAVKYDGFAEYAQDNQMEQSDVGCFINKCGDQTKALFSNPRGIKGVSCLGRCKGEQSCATRCFAEFGSESLNAWLSCTIEENECVKVPKNVDNSAEDIGYSTTLRSFDPQSLVGTWYKTDGLNPNYDLFDCQKNTFTPTSDKELDMGIFFRVQRPPESGGGYWENALTEHMIVDVPVQPPTAGTQLVASANAATGDLNDELNPTGRTMHTAGKMYGLEFTENWYILGESDGKGSVPPFKLVAYKGHTLQGNYEGAFVYAKEATVPEAAKPAIREAATKAGLDFDAFTRIDNTCSVGDSLNDAQAGTGTSTTDWINLVVGEGGVIDWISPGWRGEYKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0F0</accession>
    <name>B7G0F0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_27696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180462.1">
        <property type="nucleotide sequence ID" value="XM_002180426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0F0"/>
    <dbReference type="STRING" id="556484.B7G0F0"/>
    <dbReference type="PaxDb" id="2850-Phatr27696"/>
    <dbReference type="GeneID" id="7201176"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27696"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_1_1"/>
    <dbReference type="InParanoid" id="B7G0F0"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="211" mass="23592" checksum="5BD1FF30BE00D2A2" modified="2009-02-10" version="1">MSITASKAASRLFVGKLQPESTALLLCDMQERFRPLIHNMETVVNTCRYMTSVGKALNVPVLATQQYTKVFGETVPDCFADPQDLQTIPNFDKKKFSMLTEDVDRVLDEWKKDTYIIMGIEAHVCVQQTCLDLLERGANVHVIADAVSSQQAYDREIALQRLQAAGCFLTTAQSAAFMLLQSADHSNFKAVSKLTVEHMKLPNEFNLALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G114</accession>
    <name>B7G114_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180771.1">
        <property type="nucleotide sequence ID" value="XM_002180735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G114"/>
    <dbReference type="STRING" id="556484.B7G114"/>
    <dbReference type="PaxDb" id="2850-Phatr46383"/>
    <dbReference type="GeneID" id="7201642"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46383"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644700_0_0_1"/>
    <dbReference type="InParanoid" id="B7G114"/>
    <dbReference type="OMA" id="CEHHDFP"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855275" description="Fatty acid desaturase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="454" mass="51078" checksum="70A6E48BDEDD8A98" modified="2009-02-10" version="1">MRQLRNIILVASSALWAGQQICFAFAPLCCQARRWSTALPNKGQRRQLEVYCAPPTTSTQIQERAPLSDAATWHRERRRQMLKKYGQQIAPLERQASSQDVAVPLLALANLSLLGMSIWSGSLPIAGVVALAAFPGSMFSLWQLQILHDVLHGSLLKKGVSSFWGIKRKTLQDQILFWGSMPSVFGYYLYLKFGHLSHHKNVGDPHQASLSQLFASDQVDFEDGDVLFVAHRMNLKGDIGPVFNMPFGKKIKMSISKSGFNSWRQGHAMWNAIMFTASFMYERLMLLLNDAIVAGTGYNLFFPNKPQIFHDECAKYARWATALRASLWIFAGWQSLLFLYLAETLWSIPPHPACAMFVTNHPSSKDGESGKCIPSQSTYAGAWYSIFTLGTNYHCEHHDFPTIPLHKLGELREIAPEFYRHGSNDNLAQVMIKAFDDPDFYACMDTGIGSTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G131</accession>
    <name>B7G131_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180780.1">
        <property type="nucleotide sequence ID" value="XM_002180744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G131"/>
    <dbReference type="PaxDb" id="2850-Phatr46398"/>
    <dbReference type="GeneID" id="7201771"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46398"/>
    <dbReference type="HOGENOM" id="CLU_898526_0_0_1"/>
    <dbReference type="InParanoid" id="B7G131"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="310" mass="35130" checksum="A1CF417105F759E3" modified="2009-02-10" version="1">MLTLLDLHEGPLSHVLSFLDTPDLTSIQQTTRWLAARTPLAWNSLDAAVVQGPSTYHHIHAVSGARIRCQRYFKAQRYARTMDYWAVRHYDYDKPVRSHTLCRECTHWVSTLRPQPIHNPQAYEFFVRMAYRKPPAIKVLHDPDDPSLIWQGFVPSIPSRGHRVFLDTQRVALTWPAMDAYLAVVDTHGADISTDHPDVLASLYEAVDNLQITVVALDRVSHHASLVVATGGFHDAVEQEEDDGAAIPAHGYLLNPRNVRTHSLRKDQDWMQVEICTTGGWTCWDTGTELCTRQAHPARFRGISVTHECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1B2</accession>
    <name>B7G1B2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180824.1">
        <property type="nucleotide sequence ID" value="XM_002180788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1B2"/>
    <dbReference type="PaxDb" id="2850-Phatr36423"/>
    <dbReference type="GeneID" id="7201559"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36423"/>
    <dbReference type="eggNOG" id="ENOG502S6H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_832774_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1B2"/>
    <dbReference type="OMA" id="VYVQRRC"/>
    <dbReference type="OrthoDB" id="10055554at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="334" mass="37253" checksum="23D25D432565653F" modified="2009-02-10" version="1">MARVNGRIRRGRPRVVEPMSSFRVIAFSTMSFLGIIAILVVFTLVRNFHGAPIKAESNFFSVADEIPDSVVSRLDVILVLGGGVPSSLDSPPVYVQRRCDDAAAVVSRHQLLPATFSKKSTKPVSSKSLPILCLSAGTAHLPQLLSANGLPIWESTSSAAYLEQKHNIQNVFVETTSYDTIGNAFYARTSHTDIVGWRKLLVVTNEFHMDRSKAIFEWIFGIDSEKRAGYELYFLSSLDGDLSEEALRARQNKEAKGLSSVRKYSTKYRTLSDVWSFLNNEHDLYKASKLVERGRSNASISLATVLEKESYGAHRNLHRNIFDRISSSIHRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1S5</accession>
    <name>B7G1S5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181083.1">
        <property type="nucleotide sequence ID" value="XM_002181047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1S5"/>
    <dbReference type="PaxDb" id="2850-Phatr36590"/>
    <dbReference type="GeneID" id="7201724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36590"/>
    <dbReference type="eggNOG" id="ENOG502RWQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1819599_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1S5"/>
    <dbReference type="OMA" id="ANMNGAQ"/>
    <dbReference type="OrthoDB" id="46546at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="142" mass="14157" checksum="489627B6775489C0" modified="2009-02-10" version="1">MSSYGYSCNNNQNHLVQKGRTTSRVLAPPGGPTSFSLGVAPPPAPKAPVVKPAIAPGPENSSTTSSNSLPSVTNKASSVESTTESPAGVVKIQSYGSSTVAGPVSSNAFASGANMNGAQVMTGRPTSRVLAPPGGKTSWTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2T9</accession>
    <name>B7G2T9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_56476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181443.1">
        <property type="nucleotide sequence ID" value="XM_002181407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2T9"/>
    <dbReference type="STRING" id="556484.B7G2T9"/>
    <dbReference type="GeneID" id="7201970"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56476"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="InParanoid" id="B7G2T9"/>
    <dbReference type="OMA" id="WREPRSF"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855759" evidence="4">
        <location>
            <begin position="20"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="116"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="408"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="632"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="818" mass="88336" checksum="2BBCEC721B927ED6" modified="2009-02-10" version="1">MKFSTAALIFAVSATASTAFVPHAFVSPKSPRPALFSTELRKTDVTADLKNGVTVNPFDQSALAAGVSPLTETGTATTSSSQHWDPQADAELAKLAAIEARAGAAAYMGQYEAQSGASLIYSKLVEHGVTVVNGFSGGAVLPLLDQFHEGHPRHETSGVTPIRWITNSNEASSGHIAEGYAKSMPINGPHKPVGVAVATSGPGVTNLITPLQDAICDGVPLVVLCGQAATVAPEDAFQSSPAVDLTRPCTKWSYQIKSAAEIPLVMDYAFYIARNGRPGPVFVDLPKDLLNQILTGDLINSFIDAENPGDETSFARLQKMYRPDGEVFQALHLGTGGKGLPFEIYKDEAAPQNTPTYKLKPVTHANTVDSYHADHHPSDRVIRTGKVVAGEHLPNEQGPLQVGGEMTKKITDLIMKAKKPVIIAGQGCNDASAELKIFADRLQIPVATTLHGLGCFDERSELALNMVGMHGHPTPNFMVQEADLIICVGSRFDDRITGRMSDFVPEARVAEEEGRGGVIHVDIRLTENAKQISPTFFVHSTGKKFLETMIEFLAGMDSKPNTSAWIKRMKELQKEYPVKIPSFPSETVSVTNEDGSTTETTRTRASAQSVVAELDRQLLAADAMDDAIFTTGVGIHQMVAAQLITWTQPRQMLSSGSLGTMGVALGYSIGAKLANADKMVIAVDGDGSFNMTFTELKTLAEQGIPVKIMILDNDGQMMVEYWQRLFHDNRLIAVRNSANPDYSTLAKAFGIKSVYCDCEEDLEARMKEFLFDDPDEPVLFHVRIERTPCLPLVAPGQPLQDMILEDVEVDVDKSAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2X9</accession>
    <name>B7G2X9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181462.1">
        <property type="nucleotide sequence ID" value="XM_002181426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2X9"/>
    <dbReference type="PaxDb" id="2850-Phatr47234"/>
    <dbReference type="GeneID" id="7201989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47234"/>
    <dbReference type="HOGENOM" id="CLU_1059451_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2X9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="262" mass="28034" checksum="2164B6EDA596D92D" modified="2009-02-10" version="1">MCLDQPLAQAFQLSVFTTPISSLYNLGMKSPSITMSDLWTRGLVVLATPEPWEQHSVTKKTLRRTRKRCTYALVVLLGIVGLLGVTLGITNRTNSRTESQTTAITATDGTTTGDANGNSDNLDGDTNNALSVSQTSHVIAWPVATSCLDEPFRPLVRVSCGATETVRIRTVQNANRTLTSDRTNVATCVPNQLANSARLAVAFGTVPAPCRGPSAPSKRCCPRRSLPTPPITLRTNPDQSCEGMLTEILDPIMGLNPANPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G304</accession>
    <name>B7G304_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_37519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181704.1">
        <property type="nucleotide sequence ID" value="XM_002181668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G304"/>
    <dbReference type="PaxDb" id="2850-Phatr37519"/>
    <dbReference type="GeneID" id="7202499"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37519"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_4_1_1"/>
    <dbReference type="InParanoid" id="B7G304"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF61">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35066" checksum="1F274C39A3DE4522" modified="2009-02-10" version="1">MTATVVPCLGFTSPAETITSQKELHDKIMKIQRKKLRKCGAMDVKRPFVIKTQLVSPDSSGKWTGGDENATSNEEKVHTKIIHFQRHGQGYHNFIGNTWRELGKTVDIDSSDPDKNPFVHPEVLDAPLTALGRQEAIEKRSVAALMNPDLIIVSPLHRAIQTAHFSFADHRSRVPWIAHEGCREDLGFLVCNKRRPLSQTKEEFPYIDFSYVVSGEEDTLFKHEEMECLLAQADRVYDFLANFVRTRPEQEIAVVGHSAWLFNMCNAVVECNGDENLMAWFGTSEIRSMRVSFIESSSMSSKECKTCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G360</accession>
    <name>B7G360_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_51058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181561.1">
        <property type="nucleotide sequence ID" value="XM_002181525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G360"/>
    <dbReference type="FunCoup" id="B7G360">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G360"/>
    <dbReference type="PaxDb" id="2850-Phatr51058"/>
    <dbReference type="GeneID" id="7202526"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51058"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_0_1"/>
    <dbReference type="InParanoid" id="B7G360"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000026">
        <property type="entry name" value="V-type h-atpase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27891" checksum="D22223C924608615" modified="2009-02-10" version="1">MSEVPPTRMNQQIFKAKKKAAEGGHKLLKKKADALKVKFRDYAKSIAETKSSMATDAASAFFSMTQAEYAAGNFKRKVAEGGMTARVRVGAGVDNVAGVKLPVFTKYETGATAENQSLGLVGGGKKILAVREKFTVVLEMLIKLASLQTSFQTLDEALKVTNRRVNALENVTIPRIEGVLDYISRELDELEREDFTRLKLVQGKKQEEAKEEEKAKAIAAKLAAESGKPVLARGKENDEDITAQYDADDDADVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3F5</accession>
    <name>B7G3F5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_6789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181779.1">
        <property type="nucleotide sequence ID" value="XM_002181743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3F5"/>
    <dbReference type="STRING" id="556484.B7G3F5"/>
    <dbReference type="PaxDb" id="2850-Phatr6789"/>
    <dbReference type="GeneID" id="7202473"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6789"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805261_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3F5"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="132" mass="14488" checksum="1025A69937B82716" modified="2009-02-10" version="1" fragment="single">MEPKDSPQHIGLKRASVLIPLFRRPSSGIHVLLTQRPKNMRTHAGEVCFPGGQQDPEDEQDDVVTALREAYEEVGLSPEHVRPICRLPTIESVNHLCVTPIVALVEPSSAAEPHQLKISQAEVDAVFSVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3P7</accession>
    <name>B7G3P7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181472.1">
        <property type="nucleotide sequence ID" value="XM_002181436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3P7"/>
    <dbReference type="PaxDb" id="2850-Phatr37400"/>
    <dbReference type="GeneID" id="7202338"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37400"/>
    <dbReference type="InParanoid" id="B7G3P7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="107" mass="10799" checksum="926986AF70A0B4E9" modified="2009-02-10" version="1">MFGRDKRTGRGGSGHGCAAGEPRKGVGNTFGRCFGDPDAVATVVVQGWAEIPTFDSVGGPSFASSRLDVNKDASAGRSLGGAVKVKGAVELGMSRQFGIDAGAAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G460</accession>
    <name>B7G460_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_14380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182016.1">
        <property type="nucleotide sequence ID" value="XM_002181980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G460"/>
    <dbReference type="STRING" id="556484.B7G460"/>
    <dbReference type="PaxDb" id="2850-Phatr14380"/>
    <dbReference type="GeneID" id="7202802"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14380"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_1"/>
    <dbReference type="InParanoid" id="B7G460"/>
    <dbReference type="OrthoDB" id="47834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000016">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="25603" checksum="1BA5859E5370C1F6" modified="2009-02-10" version="1" fragment="single">NVDIYIVDSGIRPTHIDFHGRVSCGLNLVPDETCEDLHGHGTHVAGIAAGQTHGVAKEANLISVKVFNRHGVALISQLLGAVEFVIRSRSLRGNGTAVVNLSVGTAKSWSLNWAIEKASKEGLVFVVGGGNNGGNACSYSPSSAEAAITVGATTIADNRASFSNIGPCLDIFAPGETILSASHTSDTATATKSGTSMATAFVSGAAALYIEQNRSLNAFEIKSSILESTVPGIVRDLPEFLATPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4N7</accession>
    <name>B7G4N7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_38005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182106.1">
        <property type="nucleotide sequence ID" value="XM_002182070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4N7"/>
    <dbReference type="STRING" id="556484.B7G4N7"/>
    <dbReference type="PaxDb" id="2850-Phatr38005"/>
    <dbReference type="GeneID" id="7202717"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38005"/>
    <dbReference type="eggNOG" id="ENOG502REAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298338_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4N7"/>
    <dbReference type="OMA" id="MEWIANI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08255">
        <property type="entry name" value="2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF19">
        <property type="entry name" value="D-GULOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855831" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111706" checksum="52C2FADBA65F5CC8" modified="2009-02-10" version="1">MRREVRLLLRPMRGLCFLVSVVYVVAVSGPSSSTTTPGYVPPDRLWLDVDNTLYSESILSGIGRGIEAQIVRGVHEFYERFESDDTDKVAASASPQERADALHQQYGSTIEGLRQTRWKNLLPNELSAKMRNFYERVYQDVDVTALLDTDRSRHSHGGASSTGYSHNAVAQQQTLLRDALRYSPVPVGLASNSPKRHISKVIQALGLTRIPWHAVCTPDCADAPSLGANIPFRSDTGCKEDFPTKLSPNFFPNVRGICEVLLDDSPTILRSVEALQKNLQGILVSEKSSLLQGLGQAIGWTDPAFEFSQMEYLRAKNVVDMESIHEGTWQRLGMELRAQRKEEFNNAKGTLSTGSPLCVVDVGAGLLSMLRLILHGHGARLPSLVHLLRENQHPGVSSLEYYAYEPNRELGYAATVELERLGFGLQQTLQWEDSSSPTPQSCQEFIMVKPANTTDDQPKVTVYLRFWDYQREMHRPQPTPHVIVGCCFADLMDPYELSRSLLRRFLAPPSLSHFDHTLVYFPITFCGVTQFLPPQPMEWIANIPSDTTAFALYAKALREIHGHSLDPYSLEQALGDYGATCLARGQSDWQIDPSRDEYLWETMLYFFGTVTSSVLEKAAWNALGWLERTRGLRPSIQVSNTDLLFRFPHVGSWQVKSEQSSDTSRNQTHTFQEIQFTAPFKVKAISRKLVALGPNQVRIRAIHSLISSGTELKIFKGLFEDAALDLNIEGMTEERMSYPLSYGYCSVGRVVECGMDISNPGDILGKLVFTFSSHASEVVTDRDAIQIVPDGIGALDAIFMPSVETALSIVHDAHIRMGENVAVFGQGLIGLLVTALFSKQGFDTSGRLRALTVFDMLPDRLAMSALMGATQALLPSEVKTAGPFDVAIEVSGNGRALQAAIDNVKEGGRIVIASWYGSTAVDLNLGIEFHRSHKILKTSQVSKIPAELGSTWTKERRFALAWELVREYRPSRLVTKRTKLEDAQEAYDALENGSEIAIAFDYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Q0</accession>
    <name>B7G4Q0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_38018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181951.1">
        <property type="nucleotide sequence ID" value="XM_002181915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Q0"/>
    <dbReference type="PaxDb" id="2850-Phatr38018"/>
    <dbReference type="GeneID" id="7202909"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38018"/>
    <dbReference type="eggNOG" id="ENOG502T10D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781822_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Q0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="355" mass="40758" checksum="6AD4535AE326BF7C" modified="2009-02-10" version="1">MATPEPYFACDRRLSRAARALVQQRLQKAPMHRNHALLDHSSSSSNNDEATVWEWLDRTLVQPSSACPLLHDALQEQEQAVVLVPPVSWRSGATPDWQRRGGGRQKRPHRTRPLHWFQCGLCWKTFGTRYYLDRHLERHHGEALGTHADDLDDSCPAITWCAFLGAHSCQDTALEEEPYYDRGSGGLGDDRDVVRRKVARRAHDYVCTAETIRHAQNACHAMVHECFGGTESELGTYLTESYCSTLACPHLLYQLWSKTLGGTQAAALVLKQVHEWEEDWIYWSKEHHEMGKWGFALLLVLVLFYGLAFWNRRHRDTFALAPFSSTHAPGRPRRRPCETPQLWPVPSSPFKQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G529</accession>
    <name>B7G529_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_14529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182345.1">
        <property type="nucleotide sequence ID" value="XM_002182309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G529"/>
    <dbReference type="FunCoup" id="B7G529">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G529"/>
    <dbReference type="PaxDb" id="2850-Phatr14529"/>
    <dbReference type="GeneID" id="7203070"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14529"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_0_1"/>
    <dbReference type="InParanoid" id="B7G529"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="232" mass="25988" checksum="143C42014BB4BA81" modified="2009-02-10" version="1" fragment="single">VATETAGEAATESFRLKFKDGEKAMSPWHDIDLKNDDGSYNMVVEIPKMTKAKMEVATKEEFNPIAQDIKKGKLRDYHGPIFWNYGCLPQTWEDPTVKHPELGCFGDDDPIDVVEIGSASLGMGSVKSVKPLGVLAMIDDGELDWKVLAIATDDPLAEKYNDIGDVPESVQAGIREWFRWYKTPDDKPINEFGFDEKYLDKAEAIKVIEETNDAWKKLKAGETEAGKLWIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G589</accession>
    <name>B7G589_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182202.1">
        <property type="nucleotide sequence ID" value="XM_002182166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G589"/>
    <dbReference type="STRING" id="556484.B7G589"/>
    <dbReference type="PaxDb" id="2850-Phatr47885"/>
    <dbReference type="GeneID" id="7203100"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47885"/>
    <dbReference type="eggNOG" id="ENOG502S3Q6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083053_3_0_1"/>
    <dbReference type="InParanoid" id="B7G589"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="127" mass="14066" checksum="39BAFB49B818FF4F" modified="2009-02-10" version="1">MQLSSRLVRLSRSSYCFAIRSGSSAPPSPPQPSPHAMNHPKNHQRTPEDKRLENHSGKESIYKLGKHRSNALELVHKIAPIEVDGEMAICDGGGGALGHPLEYISLARPGTVEYCKYCALRYTQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Q7</accession>
    <name>B7G5Q7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182295.1">
        <property type="nucleotide sequence ID" value="XM_002182259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Q7"/>
    <dbReference type="PaxDb" id="2850-Phatr48029"/>
    <dbReference type="GeneID" id="7203246"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48029"/>
    <dbReference type="eggNOG" id="ENOG502SBFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5Q7"/>
    <dbReference type="OrthoDB" id="496858at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF15">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="315" mass="34237" checksum="3F60A6B19DDA551D" modified="2009-02-10" version="1">MSETSRKRTFGTLVTKKSASAIVVVRLDIRFPELPDQYPRKALLLDHEVGRRRNGLKKDPTRKGYYAGLENEHARTSTALFQRNALPEEGDEGPSSLPQQDDLFDGRTTLILVGGQSLLIVAAAIAAAILQTPNWGFGPNIVFDLKSIGGGFLLALPLGGLAAALDLIEDRFPALQDVTKATQRSILALMGGTFKPLFAFFTALALGLAAGFGEEMLFRGILQYELANRFGPVLAVGAASIVFGALHAVTPLYAFLATLASVYFGAIYLAFDNLAVPIWCHTIYDVGALYYAHWTVCQLTQQERNEIAFWEGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5W3</accession>
    <name>B7G5W3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_14736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182614.1">
        <property type="nucleotide sequence ID" value="XM_002182578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5W3"/>
    <dbReference type="STRING" id="556484.B7G5W3"/>
    <dbReference type="PaxDb" id="2850-Phatr14736"/>
    <dbReference type="GeneID" id="7203451"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14736"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5W3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="279" mass="31541" checksum="521FDCA259D4FF79" modified="2009-02-10" version="1" fragment="single">MKPGSRPPVILPWVGFGTYKLGKTQAMSATLQALQQGYRGIDTAFIYGGETTERLVGQALNQAFQKGIVHSREEIFLTTKHWRKYHGYDLTMECLRLSLNRLDTSYLDLYLMHWPGPAWTTMCRNKDERAETWRAMEDAYRQGLVRAIGVSNMTVQHLRKLKESASIWPPACNQVEVHPLYPQTDLLEYCQREGIVVQAYASLGGQDTGNIATSDLLHAEPVLLLAKIHSVTPAQVLLRWGLEKQCAMIPKTTKVTRLRENAGALRFALSISEVEQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Z3</accession>
    <name>B7G5Z3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Membrane alanyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_29309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182486.1">
        <property type="nucleotide sequence ID" value="XM_002182450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Z3"/>
    <dbReference type="STRING" id="556484.B7G5Z3"/>
    <dbReference type="MEROPS" id="M01.005"/>
    <dbReference type="PaxDb" id="2850-Phatr29309"/>
    <dbReference type="GeneID" id="7203265"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29309"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007993_2_0_1"/>
    <dbReference type="InParanoid" id="B7G5Z3"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09600">
        <property type="entry name" value="M1_APN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000002">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000002">
        <property type="entry name" value="Putative aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="entry name" value="Peptidase M1, alanyl aminopeptidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322:SF1">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="199"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase Ig-like fold" evidence="10">
        <location>
            <begin position="418"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase C-terminal" evidence="11">
        <location>
            <begin position="512"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="94634" checksum="8AF962D4B89F4334" modified="2009-02-10" version="1">MTLVANPRYVGEPIPLVLDGDETCLQLRSVRMNGQELREGVDYELAPGRLLLKTPVDGAVVQTVVDLVPEENTQLSGLYKDEASAMYCTQCEAMGFRRITYYPDRPDNMATFTSVRLEADKERYPILLSNGNRLDQGTVPEDDSRHYAIWSDPFPKPSYLFAAVVGKLGSIRDSYTTVSGKKVQLEVFSEPRNVHKLSYAMESLQRSMQWDEQRFGLEYDLELYNVVAVDSFNMGAMENKGLNVFNTAYVLADEGTATDTDFERVEGVIGHEYFHNWTGNRVTCRDWFQLTLKEGLTVFRDQEFSGDMNSKPVKRIEDVRVLRARQFSEDAGPMSHPIRPESYISMDNFYTGTVYIKGAEVIRMYQTILTPEGFNKGMKLYFECHDGSAVTCDDFLAAMADANNVDLTQFALWYSTPGTPTVQYETSYADGTFTLKLSQSSRSVTPMHIPVAFGLLDKATGQEVVPTTVLELKEASQVFTFDGLEGDVVPSLLRDFSAPVKLEPVSGEVDESDLAFLAARDTDGFNRWDAGQRLYTSLIFQTLNDQISSTTQAFVDEAFRMALEQKTTDYSIQAYALTLPSESTLSEEMKIVDPVGLHEARGKVKKALARKYESEIRTTYDGLTETMQAETEFKVDAEAIGRRRLRNTLLEYLCSIRETDQEQIAAAELAMKHFQNAKGMTDKIAGLGALASMDGEGADARDEAMQTFYDDAEGDALVLNKWFMTQAVADLPDVLNRVKKLKEHPDFTLKNPNRCRSLISAFAMNSAAFHDESGEGYKFLGSTIAELDKLNPQISSRMASSLIQWRRYDEERGQLMKAELEKLNAMKLSEDLFEIVSRGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G655</accession>
    <name>B7G655_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_1129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182516.1">
        <property type="nucleotide sequence ID" value="XM_002182480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G655"/>
    <dbReference type="FunCoup" id="B7G655">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G655"/>
    <dbReference type="PaxDb" id="2850-Phatr1129"/>
    <dbReference type="GeneID" id="7203490"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1129"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_3_1_1"/>
    <dbReference type="InParanoid" id="B7G655"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="420"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="562" mass="62076" checksum="264BE34EFDD41C30" modified="2009-02-10" version="1" fragment="single">QEAGVIFDVLVVGGGATGAGTALDAASRGLSVACVERGDFASETSSRSTKLIWAGIRYMGTATAALLSPKLWQHPVDTVHQFVGEMKMVWHCHVERRYMTSVNRHLCNWIPIAVPFNSWHISPPPMGHPLFGYFPFLAPVVFKFYDALSVFTCPPSYVLTKSRAQRDFPQLDPDGLKYAAVFYEAQHNDSRTNLAIAMTAAEKGAAIANYTEMVDLIHNEAGRVVGAVVLDRMTGKQWKVYAKKVVLAGGPFTDQLRSMEAGKIPPAVRGSAGTHIVLPGYFVPHNMGLLDCNTSDGRFLFILPWLGHTLIGTTDKKGPAETLQNPPEDEVVWLLKESQKFLRKDLKVRRSDVLSAWRGWRPLAVDPHATADSPVSRDHVISENPESGVIFIAGGKWTTWREMAQEVIDRVVGPSGPPSLTLDIPLHGAEGYENNLAIQLIQRYGMDTTVAEHLVKTYGGRAWEVCELMQPTGKAWPKFGNLLVEGFPYIDAEVLYATREYACTIEDVLSRRTRLAYLNRDAAVAAIEPVADILARELGWTAKAKEQQIQAARNYVESYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7B3</accession>
    <name>B7G7B3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183000.1">
        <property type="nucleotide sequence ID" value="XM_002182964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7B3"/>
    <dbReference type="STRING" id="556484.B7G7B3"/>
    <dbReference type="PaxDb" id="2850-Phatr38958"/>
    <dbReference type="GeneID" id="7203708"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38958"/>
    <dbReference type="eggNOG" id="ENOG502S2WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540219_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7B3"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169:SF1">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855910" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="363"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="502" mass="55339" checksum="124C22E93205174A" modified="2009-02-10" version="1">MSASRFVVAVLVLGVVRLSSGWILTQNHPHLRFFRTTTTPTRSDFRHGLTLQQAVRGVAAAGVEPDEWEALRPRLAAVCRDCIDQDLESDGILFLPSLTGDPESQFAGIAGRVLLLSIDSWVAEDGVVLLFDAATAAIDELLQDETVRTTEGHAQPILLYIQPENVTSVVQSDSMQMENLLQTLISNDIDQYGLADIVGGDVGFGLPLTTVVPTDQFEVDGATVRDPLQRTEFWDTSSVLVFDGLVTRDLRQRLLELILDETNSDEKWDDVANGPNPSRWVRGGLMDIPAGQGSTDEAEESDSLGGYGLTDEAIDELCFEDHEAIEEFESIVSALFPHMRIARLPEAVLGSSVSPLTANAPIHGHSFKYHIDADPNLVPQSPWADVYGRYPNRTPGKPRFISCLVYLNDEWDYDAWGAPTRFLDYATESACDIQPKPGRIVFMDQDVTHTVVAPMSAAGLRPRYSLVWKLILHPTRYNQDMTDLAGPGRNWPAPTLIGSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7I2</accession>
    <name>B7G7I2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183022.1">
        <property type="nucleotide sequence ID" value="XM_002182986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7I2"/>
    <dbReference type="PaxDb" id="2850-Phatr48509"/>
    <dbReference type="GeneID" id="7194761"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48509"/>
    <dbReference type="HOGENOM" id="CLU_1463978_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7I2"/>
    <dbReference type="OrthoDB" id="39328at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="20027" checksum="FBB005063B7A0592" modified="2009-02-10" version="1">MKLLGMSMESEKVPKGKQYMISTRENSEYKWQNEPGIIGALEVPSQPGLNLQEEYIQRTIEGKKEAFAAALRVWEHWKLRDEFIRACENVPKETCCCGLVPDDDSTMKSMIPALNKGWMKAVNERLSKDGKDFHLDSFVWNWHNAVGKSETNVLMIRFHEGNVEPSSWGLNHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7W7</accession>
    <name>B7G7W7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_48620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183219.1">
        <property type="nucleotide sequence ID" value="XM_002183183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7W7"/>
    <dbReference type="STRING" id="556484.B7G7W7"/>
    <dbReference type="PaxDb" id="2850-Phatr48620"/>
    <dbReference type="GeneID" id="7194882"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48620"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7W7"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="200"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="645" mass="71369" checksum="296F6E27F5817595" modified="2009-02-10" version="1">MPFNLRTSFSAYLIVLFSAICFVKVWGFRSVAIAQTSMSLLQVRCASSRISPSDGSMSVRSSQRNKASSKRRKSVSDETIISKRTAFLKSWLLHNENEFHSFSKDEADAIRESLLVWYRSNRRKLPWRGDEPPWGGSTIAFAAKASAVSSNKKQASLKEFFATSVVNLSATKRDEDVDAPDDHKKSFPVTAYGVWVSEIMLQQTRVEAVVPYWVRWMIRFPTVHDLALADEDAVNAHWAGLGFYRRARLLHSAAKYIVNDCNGALPENVQELLHLPGVGRYTASAIASIAFNVNVPVVDGNVCRVLARLRGIANNIKAPALKDNHGWDLAAQIVSAGDGSAPGEVNQAIMELGATYCAPGGTGLDENDPLKDFYFSTRIGREVLRAFDGNDLKQISELRYASSNAQQCSLCAHGGVAEVFDILEVELSKALESKASVSRENIASKCGHSSFPLSPPKLAKREEVLAVGALKWLGPNTMEPAWLLHRRPEKGLLAGQWEFPSVCVWTSETVKPKGKRKNSSDRVPIVSACVRRKALESLLRDVASTDKKFLDCWASAMSLKQCPVGEGPIEHIFSHVRHTMWIESVDLSQALSLSIMDGVQLACAGREMRWMTESQMKEVGVTSGVRKILKSLEQKNPKKRKNMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G844</accession>
    <name>B7G844_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_22658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183411.1">
        <property type="nucleotide sequence ID" value="XM_002183375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G844"/>
    <dbReference type="FunCoup" id="B7G844">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G844"/>
    <dbReference type="PaxDb" id="2850-Phatr22658"/>
    <dbReference type="GeneID" id="7195186"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22658"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="InParanoid" id="B7G844"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="7">
        <location>
            <begin position="218"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43680" checksum="65451F7F0BBD5BB9" modified="2009-02-10" version="1">MSAAAATTSSAGTLRFEDGAVQFRQRIVVSILSHRSLLIRNIRAEDIDAPGLRQYEASFLRLIDSMTNGSRIEINSTGTQLRLSPGVLTGGSIEHTCPVPTQPTDSRPDEESMDSSRSIGWFLEGILPLAPFGKEPLSVSFFGITDGTCDVDPTSDYLKASALPLFQKFGVGVTDAEDFLSPQAPSIRVVRRGAAPAGGGRVELYSPVVQVLQPIEFTDPGKFKRVRGTAITCKIVSSSMAARVAFASKGLLHRLLPDVWIHTDAHTIKHHKCGPSPGLSLVLTAESTNGVVLTAECCLDYRKDASRELPEDLGTRGSALLLNEIRKGGCVDTGMQSLALLWMCLSPEDVSRIRVGTLSQYAVESLRLFKQAFGVEFKVKPDHATKTVLLSCLGSGYRNMSRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8J2</accession>
    <name>B7G8J2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_15286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183479.1">
        <property type="nucleotide sequence ID" value="XM_002183443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8J2"/>
    <dbReference type="STRING" id="556484.B7G8J2"/>
    <dbReference type="PaxDb" id="2850-Phatr15286"/>
    <dbReference type="GeneID" id="7195085"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15286"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287783_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8J2"/>
    <dbReference type="OrthoDB" id="45345at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12300" checksum="6272D36A2240EAD0" modified="2009-02-10" version="1" fragment="single">MRTELLTDTSIPILFFDEIILFEDDLHDNGQVEFSVKLRVMPSCAYVLARLWLRVDNVVVRIRETRLLVDFFGIKPKIFRDVTWRECYWGELGAHGLPTDVRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8W7</accession>
    <name>B7G8W7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_15666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183664.1">
        <property type="nucleotide sequence ID" value="XM_002183628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8W7"/>
    <dbReference type="STRING" id="556484.B7G8W7"/>
    <dbReference type="PaxDb" id="2850-Phatr15666"/>
    <dbReference type="GeneID" id="7195218"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15666"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G8W7"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="235" mass="26582" checksum="A5F02910E333DCA8" modified="2009-02-10" version="1" fragment="single">LQIVYHDSDIVVVNKPPDVLTVPGIHSRSCVLDLVHDRFGEAVQDKAHMIVHRLDMATSGIVLFGRTLNITKRMQAIFRDRLVLKTYQALLMGHFPIDKGTIDLPLQRDHEYPPFMRISTPTSEADAVQAVKDLQQHGWKKLIRKKPKPSQTSFRVLARSFRNGLPFTRMELVPVTGRTHQLRVHCAALGYPIVGDPTYDEYVPNEKAMCLHAALLQCEHPTTGMPIVFEASPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G973</accession>
    <name>B7G973_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pt-KIF13</name>
        <name evidence="7" type="ORF">PHATRDRAFT_7359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183587.1">
        <property type="nucleotide sequence ID" value="XM_002183551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G973"/>
    <dbReference type="STRING" id="556484.B7G973"/>
    <dbReference type="PaxDb" id="2850-Phatr7359"/>
    <dbReference type="GeneID" id="7195275"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7359"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317007_0_0_1"/>
    <dbReference type="InParanoid" id="B7G973"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="138" mass="15520" checksum="B8CB71016B6E054C" modified="2009-02-10" version="1" fragment="single">LFSYGITNAGKTHTVLGNISKKKEAWGLVPRAVSDALDRLPPTAHLTMSYFEIYNENVYDLLPQSLQNENVAKFADPLKVREWHGRAVVSGLAKHRLHSLQQGLDLIVMAKQRRHTATNNINRDSSRSHCVCQLTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9P7</accession>
    <name>B7G9P7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Longevity assurance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LAG1</name>
        <name evidence="8" type="ORF">PHATRDRAFT_49163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183929.1">
        <property type="nucleotide sequence ID" value="XM_002183893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9P7"/>
    <dbReference type="STRING" id="556484.B7G9P7"/>
    <dbReference type="PaxDb" id="2850-Phatr49163"/>
    <dbReference type="GeneID" id="7195657"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49163"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838013_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9P7"/>
    <dbReference type="OMA" id="RYNFLRY"/>
    <dbReference type="OrthoDB" id="43800at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="112"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="332" mass="38211" checksum="A2D0866AA676DCFA" modified="2009-02-10" version="1">MDTFRRTALAFESFRKLSGAFVTTVTEDTGADTYSIDNDATCPTTKFYLELRSDGTEPCSGTDWIILFLLVCLIHCISWGGRWLVWEPLANALAHHGQKHSAWNRADCQRLSTSMTACSFFLFSAFSVWRILFHKPWLWNARQWTQDLEAKHIDADFKFYYLLYAARFCSDSISLFFEDRRKDVFWTSAAHHLITLGLVLGSATAGLTRMGGVIMFFFDWADPPLLLAKSLKYLSRHPQDLYQTLANRLFEVFAVVFILTRNVLYNYVVYIGVRDLPPWAWISRLLLVLLAVLQTYWLSLLVQAILRQKQNNGVVEDMREKDVSAVATKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9R5</accession>
    <name>B7G9R5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183936.1">
        <property type="nucleotide sequence ID" value="XM_002183900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9R5"/>
    <dbReference type="PaxDb" id="2850-Phatr49182"/>
    <dbReference type="GeneID" id="7195628"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49182"/>
    <dbReference type="eggNOG" id="ENOG502S188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1051548_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9R5"/>
    <dbReference type="OrthoDB" id="4311at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.90">
        <property type="entry name" value="Protein of unknown function DUF1823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014952">
        <property type="entry name" value="DUF1823"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08853">
        <property type="entry name" value="DUF1823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="35522" checksum="329A412277F5CB32" modified="2009-02-10" version="1">MYLISFPNETSVKKPSSSRGHSDAIMPKLTVLRSFQGNGSLIIATKSMRSSGRAMIFYSGIGISLLISSLSVGEAFVLSRKQSKSACNCFQLYSLSSEEESPERQLKKAVKPDILKPFLPAADPNYMNEGPVGENDFILSRDGEPKELELSNENLLRILRVECSDLEVNTLVWKCLGYRFDPHANLWNNDKCFPKWKEKYPTPPDLIGMQRIYSPEIDKPSLRANQAIVRSIPVDNKQSLKTHLKPYGFTGYQFAELTPNKTRRAQCANWLLYFREELFGFTVEELRKRRQAKKEAGEGQGDEWKPPVREVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA58</accession>
    <name>B7GA58_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184013.1">
        <property type="nucleotide sequence ID" value="XM_002183977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA58"/>
    <dbReference type="PaxDb" id="2850-Phatr49305"/>
    <dbReference type="GeneID" id="7195477"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49305"/>
    <dbReference type="HOGENOM" id="CLU_512410_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA58"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855616" description="Membrane-associated protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57993" checksum="FA892851C40E13CD" modified="2009-02-10" version="1">MARTSLALLGSLVLLMVTQFLMLPLLVTTVLQDASDRNSLTNALTHSLQSNAIGSTTATGVATSNTSRKRPIPDRGPPDGAFNGVPLYLQTATPDLHSNVHCVGRSCRFDFLCFNVSENDFVVFQSAREQALSTATIPRPFVHTSDTMLRWGPNHTQTVSIGGINQKWGANGLRRLEWFPKVVPLPDSGSPPFAYYALPEEMVWTPLHSLNAANPGHLVWDDFFPVYTLLHMFDLLDRHPLLLRYVLKDGLRGLWASCDFRPDKEEACQHLMTKFAPLMWGTESSWRFTASNNFTFVANGDVDGKDRVDLVCARTGVAGMGSLTDHGVTKSHGWMPEDYVLTQNHGRGGMLREFRHYLLSNMGLALPQSVLQERPHRVVFSVKSSSIRNRKMDFERQMGVVSAIEGVAVESYSFQDLSVREQVEIASRTSVFVTACGGAAVTASFLPAGGAVVLYYSETGGYKNNLNTKLPALLDWDVFNAMSYLRVHWMPRNTVDSEIDDQALMLLIEHEIYLMESNALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA87</accession>
    <name>B7GA87_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_15848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184027.1">
        <property type="nucleotide sequence ID" value="XM_002183991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA87"/>
    <dbReference type="FunCoup" id="B7GA87">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GA87"/>
    <dbReference type="PaxDb" id="2850-Phatr15848"/>
    <dbReference type="GeneID" id="7195596"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15848"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA87"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="206" mass="23479" checksum="8BE0E9BC14E94E8C" modified="2009-02-10" version="1" fragment="single">KIVVAKERFSKAYRHPVLDERLTKQRCRAEARILEKCQIKAKLDVPSVIRMEAPVLYLEWIEGITVRDFIESMLSEETDSSRKACKYKTLLSVAKQIGTIIGTLHSFGMVHGDLTTSNMMIRQRTGIRLVLIDFGLSKNTESAEERAVDLYVLERALTSTHPSLPEGFYEETLLSSYAETAGTKHEATLTRLEQVRQRGRKRECFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAK9</accession>
    <name>B7GAK9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184095.1">
        <property type="nucleotide sequence ID" value="XM_002184059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAK9"/>
    <dbReference type="STRING" id="556484.B7GAK9"/>
    <dbReference type="PaxDb" id="2850-Phatr49437"/>
    <dbReference type="GeneID" id="7195802"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49437"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_8_0_1"/>
    <dbReference type="InParanoid" id="B7GAK9"/>
    <dbReference type="OMA" id="THIICCT"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853155" evidence="1">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="308" mass="32070" checksum="CBF40D253BF709A5" modified="2009-02-10" version="1">MRLSLAVTLISVLGLAAGFLEVAAFSRTTQLVRCESPRSVADAVRNTRLCAALQSGDGVLVIGGTGGVGQLVTQKLAAAAYDVRVASRDPARAAAVLANDNVRVVSLDLLSATPADLDAALQGTAAVVISVGTTAFPTMKWRGGNTPQAIDQEAVTNIAQSARTVPGLKKVVLLTSVGVDRTGEMPFLILNLFGVLDAKKAGEQAVVDAAVHSGFEYAIIRPGRLVGGPYTNPDVAKLLQVQGGAENGVDVQPGDSLLGDCKRDACAEAVVQCLINEECRNVDFSIASNDQPALTNEAWNQAFRSMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP8</accession>
    <name>B7GAP8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_52561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184232.1">
        <property type="nucleotide sequence ID" value="XM_002184196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP8"/>
    <dbReference type="STRING" id="556484.B7GAP8"/>
    <dbReference type="PaxDb" id="2850-Phatr52561"/>
    <dbReference type="GeneID" id="7195822"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52561"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAP8"/>
    <dbReference type="OrthoDB" id="422555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17706">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="260"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="675" mass="73699" checksum="E03C403DDEA17B57" modified="2009-02-10" version="1" fragment="single">MALAIVNAYAQKQQHQQQSTTDEHCTSYETEVDRFIGSTQIHVRFVHVQPTVQMMDIKTGLVGKLLTVQGHVVKARPKRLRIATADFACGKCGVLVTHAFTAGRYSLPTRCSGTSCTSRTFSLVRPTTRYTNVQELRLQEAQEESISHAGRTPRQLVVECVQDLVDVCRPGDLVMLAATVAAVNTAVAAGKTGKRAQETSTYQLFLQAHSITTLSERGSRSQTSKTTAQVVYTSQQLQAITQLCHADHRYFGLPERRAFPFDLLVRSLCPSIIGHDEVKAGLLLCLLGGTPPSSSGGGMDKGQSIRSNSHILIVGDPGMGKSQMLLAACQLAARSVYVGGNTSSTTGLTVTLTKEEGGESGIEAGALVLADQGVCCIDEFDKMAKNHQDGLLEAMEQQQVSIAKAGVVASLPARCSLIAAANPKHGSYNMNKTVAENLNMAKPILSRFDLVYILRDRANKEQDRMVSSNIMNLYRNGSNNNPLMHSDIDLSQRVMTAGNGKVRDYIAYAREYCKPKMTAEAATVLKDFFMDLRYPADGGRRPRDTVPITTRQLEALIRLCQARAKACLRDFVLKEDALDVVELMSKSVEQVHRDESGVLDPIRGGAGGKSNKKMKKAFVQEMQRLIGAGAECSLDDLRRIADKVNCGLSEFQPLVEDLRSNGIILRKSNGNYQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAR5</accession>
    <name>B7GAR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RpoT</name>
        <name evidence="12" type="synonym">rpoT</name>
        <name evidence="12" type="ORF">PHATRDRAFT_49483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 9"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184121.1">
        <property type="nucleotide sequence ID" value="XM_002184085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAR5"/>
    <dbReference type="STRING" id="556484.B7GAR5"/>
    <dbReference type="GeneID" id="7195832"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49483"/>
    <dbReference type="HOGENOM" id="CLU_003364_4_0_1"/>
    <dbReference type="InParanoid" id="B7GAR5"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1188" mass="135684" checksum="C2BFE735AA60844F" modified="2009-02-10" version="1">MQSHLFRRSRPWGRPYPLHCGARASSAQPCFTVTIAARLRYSSVSFGNIGGMPSTPWQSRPRYYRSYSLTFHTGNTNFNSNNYHQALAGVRSFRSTAGAWAPTRTAIQALSTDALHDEQNDEAMSESVEDLFRAELERYTFHAKARMMPGYEHYNPTKYDDIDNDASVSASQDLQVELDTGNESLFASNNEHARKLGSEVTWEEELVDLEQIDLDEAVRSPEAANAHQPNPPTSNHKTQKSAVELLLAFDPQNPPSCDDLEELQLWLECEAQQESITRYQHVIDSARTRKDYASLSLVQRHVLQWYQPLKHEIESLQKAYIFKEQDPEGVVLTKRAANVYGPFICSLPPEKLAVICAHEAIMSGLSNPGVDGRDGTAFTAVARRIGDAVEQEVVIQRMLHRRFKESQARHSTQDPNRILPKPEEEVEGDVELSTDKIDEDMNDGNATTRSKSSTGTEDVHKWAYAASHLKNYLDEISYRKPSVKKRLVIEYAIRRARTILENDEAWTESQKIQLGAVLFQVLLNKANVRIDGKQEKAFTYEKFWISKQKVQSIVSMNDRLHKMLVSDKLQSFGTTTTRQKPMIVPPKPWSRPDEGGYKMLRTELLRYHGCNMQKEVLQNVDLSIVFDGLNALGRVPWRINQRVLTVAQRCWDNNIPLGDIPSKDDNPLPEEPLHPKRQEQFWEPETPGYESYVEEYRLYRESWNKFRRVKQRNMDLRSLRCSAMLKLDQAEKFKEFEEIFFPYNMDFRGRAYPVPPHLSNVGSDLCRGVLKFAEAKPLGPRGLYWLKVHLANFAGKDKMSFDDRVKFVDDNLEQVRLSAEDPFAGERWWMSLEDPFQGLATCLEIIDAIDCGNPESFLCSLPVHMDGSCNGLQHYAALGRDSVGGKAVNLCAYDEPQDVYVGVMHEVVRRVAAEAERQLDFDTSDLESLSRKQKKELSYNRAAKLVNGLIDRGVVKRTVMTSVYGVTYIGARQQIQEKIISKLEAQGHDVDEMSNEIFQACGYVASLTMEVMGDLFTGARETMNWLTTCARMITQHGFPLAWVSPIGLPAIQPYRQKKAATIVTLLQTVTLINESDDLPIHKQRQVSAFPPNFIHSLDSSHMLLTALEMDRRGLTFSAVHDSFWTHACDIDEMNEALRDVFVDLYSQPLLERLKQTWEMRYPELEFPDIPKRGDLNLAEVKQAKYFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB83</accession>
    <name>B7GB83_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184421.1">
        <property type="nucleotide sequence ID" value="XM_002184385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB83"/>
    <dbReference type="PaxDb" id="2850-Phatr49616"/>
    <dbReference type="GeneID" id="7198259"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49616"/>
    <dbReference type="eggNOG" id="ENOG502ST0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1581583_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB83"/>
    <dbReference type="OMA" id="WTMESSY"/>
    <dbReference type="OrthoDB" id="42467at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856041" evidence="1">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="169" mass="18742" checksum="35885511A11A5146" modified="2009-02-10" version="1">MRVINPLLSLILLPIIKGWVPSGISSGTSFLQRQRAASCLRSIEVDSLLEMDVVVYSLQNDENKTERLGAVQEDGTLSPLSVWSVEPAFGDSLEFLVDEEDRFPGLTAEDVIVHRIVPQESLAYGSRQVGGGMGPSNPHGEESELLYYVDENIITNIELIVKPELEIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBB5</accession>
    <name>B7GBB5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_23371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184338.1">
        <property type="nucleotide sequence ID" value="XM_002184302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBB5"/>
    <dbReference type="SMR" id="B7GBB5"/>
    <dbReference type="FunCoup" id="B7GBB5">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBB5"/>
    <dbReference type="PaxDb" id="2850-Phatr23371"/>
    <dbReference type="GeneID" id="7198296"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23371"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_0_1"/>
    <dbReference type="InParanoid" id="B7GBB5"/>
    <dbReference type="OMA" id="DFHDLCE"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="426" mass="46811" checksum="72A7B001D0A2D6DC" modified="2009-02-10" version="1">MPPKSKKKDDGEDPNMRAARFGRVKNTLTMGFVGLPNVGKSSLTNLLAGAMHAEAANYPFCTIDPNVVQCIVPDKSFKYIADCWKPPSVVPAVLKVTDIAGLIKGASEGAGLGNAFLSHIAAVDGIYHLVRAFDSDEVIHVDDSVDPIRDLETIQGELCAKDRESLVKVLQLEKETVRKAKGMAKAAEPTLSDTFKEAYAKCEKLIAENTPIQTHEDFTAAEVEIIRDWGLITTKPQIYVVNLSQKNYIRKGSKWLPKINAWVKEHGGGQILPVSCDFEQVLFDLKDDPEKQKVFLDQCTEEAKAAGLKGPQAEVKSMIPRLIRAGRSALCLQSFYTAGPKEVRAWTIMKGTLAPQAAGVIHTDFERGFIKAEVCAFDDFKALHAGQPSMAKIKEAGKYRQEGKSYVMNDGDIVVFMHNVTTSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBE8</accession>
    <name>B7GBE8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184356.1">
        <property type="nucleotide sequence ID" value="XM_002184320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBE8"/>
    <dbReference type="STRING" id="556484.B7GBE8"/>
    <dbReference type="PaxDb" id="2850-Phatr40431"/>
    <dbReference type="GeneID" id="7198157"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40431"/>
    <dbReference type="eggNOG" id="ENOG502SDWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_0_1"/>
    <dbReference type="InParanoid" id="B7GBE8"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="152" mass="17219" checksum="DC2A5FC9697E043C" modified="2009-02-10" version="1" fragment="single">MSPTPTQAHDEMSDTLLELAEEFQAQIEIKDRKYRLKTYKDTFVGSEAVDYLVSSGKAATRTEAVSLGQVLQVNFHLFEHVTRDHDFADDGLFFRFLTDNERGGLSRDESGNSLRWQNFLGTPDGLTNQNGLQPSFPKNDILPDKDQHVVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBL3</accession>
    <name>B7GBL3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184625.1">
        <property type="nucleotide sequence ID" value="XM_002184589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBL3"/>
    <dbReference type="PaxDb" id="2850-Phatr40624"/>
    <dbReference type="GeneID" id="7198484"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40624"/>
    <dbReference type="HOGENOM" id="CLU_344706_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBL3"/>
    <dbReference type="OrthoDB" id="55634at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="266" mass="29212" checksum="AFD1E73C99215B9C" modified="2009-02-10" version="1">MLASTGQMTSSTVFSHFLDNVFSIPQGHPIRLSFAQQGYDTVEDLLGICENELGTFGYVPPTSLDTNDNPQWTPLLMAHRQILRHFLRWQASLERKKGSSLDNSELVELTSSDFAFYKRSALGQVSSVLTTATSSSSAPGIPNKPRSVFYGQKKPVYCKEDATTLSVNNTNAITYCSSVHSALRSGATNLDLMPQDGESIPKPISFVKPLGTETHNSCAFKGLPGFTPDNLIGKTFLTDSQDDGELFRERQTFPTDTQDDGEQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBL6</accession>
    <name>B7GBL6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49826</name>
        <name evidence="3" type="ORF">PHATRDRAFT_50348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184628.1">
        <property type="nucleotide sequence ID" value="XM_002184592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185314.1">
        <property type="nucleotide sequence ID" value="XM_002185278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBL6"/>
    <dbReference type="PaxDb" id="2850-Phatr49826"/>
    <dbReference type="GeneID" id="7198487"/>
    <dbReference type="GeneID" id="7199176"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50348"/>
    <dbReference type="eggNOG" id="ENOG502S5TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067229_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBL6"/>
    <dbReference type="OMA" id="THIVYIF"/>
    <dbReference type="OrthoDB" id="6352234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="133"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="36339" checksum="A6D8D0EB76675112" modified="2009-02-10" version="1">MKVSRSDSRSFSPRSGWFALPNRYSALFPWALFLIGCFIGHLHGNFIARSENSQIINECLRHDNPLCVTSHVHTDGGVDRIGDGWHSIDVFYGHTDLLKKTLPSNRTWFSQASQDELVASLFKGKRDGYFIDLAANDATDLSNTYALEQEYGWTGLCVEPNPMYWHNLSYRDCQIVGAVVGQARLEQVHFRFEAGDHGGIAGDGFDNGKRWQRYSELKYTVTLLEILERYNAPTQIDYLSLDVEGAESFIMMNFPLDKYQIKVITAERLRGPIREFLKGHGYVFVKKLTRWGESLWIHNSAKDELDLQLIQQFNFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBM5</accession>
    <name>B7GBM5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184474.1">
        <property type="nucleotide sequence ID" value="XM_002184438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBM5"/>
    <dbReference type="STRING" id="556484.B7GBM5"/>
    <dbReference type="PaxDb" id="2850-Phatr49708"/>
    <dbReference type="GeneID" id="7198394"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49708"/>
    <dbReference type="eggNOG" id="ENOG502S2TJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541308_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBM5"/>
    <dbReference type="OMA" id="KYFRFRA"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="158"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="349"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="55307" checksum="EE8E28BCE984013C" modified="2009-02-10" version="1">MDVFGSKLVEALSVYHASWLLGLSVTVAVAIAIKMSSNQKSRSPLHRKFSFTSVGMAIGIFPESVKAPTTIINAAIYFSTCPAEKDLIELAVKPMLAFTRLSTIPVPETANCRPSTRSFAPSELIRKVEISGKCIKSTNDVIFKHLQESLSTERDDLPWWEFLVVENVGEGESAVVLRMHHALADGISLVHVFEKFITYEDGSPVLSIILSNMAQKSKVEKTHKTNPFRLAWMLVRDATKVLTLGLSRSDDPTIFTEPNQTYVHSQHRECVVFPTFSLAFVKRLKTAANVTVNDILMTAVSQAVHEYCRAESCSVLMGKGASLQSRALLPIALPRSASDLEHPSTALRNKWCLVSANMSIGCVDLVDRLNSIHQTTVHLKGSPIAMVQLSLQNKLASRLPKIVARQTMLDIFRRHSLVFSNVPGPDRPCQLAGQTATGVQMFYSNLIPQVGLLSYAGNIYGNIVLDTGAVPNAESLAGHYAKALVDMATLLNVDKIPTNLQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBY0</accession>
    <name>B7GBY0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_55108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184603.1">
        <property type="nucleotide sequence ID" value="XM_002184567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBY0"/>
    <dbReference type="STRING" id="556484.B7GBY0"/>
    <dbReference type="PaxDb" id="2850-Phatr55108"/>
    <dbReference type="GeneID" id="7198370"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55108"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385198_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBY0"/>
    <dbReference type="OrthoDB" id="49610at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="621"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="718" mass="80758" checksum="69197F679063A4E4" modified="2009-02-10" version="1">MHKLPYRDCSYYCGRVGSAVPNQSTRSSWKAPLLPIYPTPVFVTPTQTDNPLFTYPPKTDNVHCIHLSLLRSPLPTGRPTRASWRLVYKNLEALSSVRLRLSMDNHNHNNNPSHVRNAFAPGAWTPWRVPPSSHEPRRDDASDTLRNQPLFSASRTSTTTRSSTTITTTNTTTGGTVSMSDKKRRGRPRTSKEGTASSTASPSTVGSKKLPQSCRCNFGLFLDTMVREVSLTRPDLVHWTRDGSGFFIHQERSADVSQILAKYFLHGNFDSLRRQLNVYGFRKQKKPGPNRGSFHHPDFHRDRQGDLDETNQPRAPSIKPSKRERRKKKESESESASDTRGGMAHRVRHTPTPQRKDDPIPPSVVAATISAVPVHEQSTGEPEPKKKKYTRKKDETNTVACVKEAMPPPPLVLPEGSADVTSLNAIIADALHESTAAAKTKSRRRKKARRLNQNYATFHHLYTTPVFSEDYSTGVYTGAVPNCAVYGPPYLPVIPEDDTIGHGIWLDGVAQEEPLREGPTKVDSDVVPERKPRKTYTRRGTAATKDAAKQAKHKDNKTVKSKPPRQKSGQREPRVRPRLEFQKRVPRAEKLPVKKDSRNIARRPVMDVDMGEIDLTDISTLPRGVTMRPSGKWQAQLYFNGRSRYIGVFDNARCAAFAYRIVHQRLRHDKYHFLSSDVATEVFAKVRIEANDAVDNLLRGKTTEKEALDRLAESESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC41</accession>
    <name>B7GC41_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184739.1">
        <property type="nucleotide sequence ID" value="XM_002184703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC41"/>
    <dbReference type="PaxDb" id="2850-Phatr40676"/>
    <dbReference type="GeneID" id="7198585"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40676"/>
    <dbReference type="HOGENOM" id="CLU_2101690_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC41"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856008" evidence="2">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="116" mass="13129" checksum="93B2A069030C0E9E" modified="2009-02-10" version="1">MKTIIATILALIACVSLTQGFTPSFSLSRPTLGLSMTGEAGQNQEGWKGQRGGQDKHDEMWEAQQELLQSRREHSGSKEERMDKYSNPDVDHHEELKNPWSKSNDKDDHYSQNGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCN1</accession>
    <name>B7GCN1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_50021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184905.1">
        <property type="nucleotide sequence ID" value="XM_002184869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCN1"/>
    <dbReference type="PaxDb" id="2850-Phatr50021"/>
    <dbReference type="GeneID" id="7198719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50021"/>
    <dbReference type="HOGENOM" id="CLU_609016_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCN1"/>
    <dbReference type="OrthoDB" id="48611at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853123" description="Calmodulin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49167" checksum="BB401EB24AF092A4" modified="2009-02-10" version="1">MKSSVLSILSLIVLARAQDIDPDLIDLPPEGIDFEGCFSDLVTADVNGDGFVKQNEYLNFINTYGKRICHYQEKLTLQQEIAFSSLACNCRSQENASPDCCLRENARIPTTGVSSPSQRTEEQSQYLTSVCVVTDDTIDGECPPVIRDRSTPPPILIAPVLADIVNDDGGLSNAAKWGIIVAAIAAALLLLLLCCCCCVVRRRRGKAVEEEEEETGVLATKSLNGQEMAPDDAAPHGNRDGPDLENGVPFAAASTPRSREDSEYTEEEDASDDESGDGRGKRGCNYMEEEDEAGRRRLRGAGEIPEGGGGNSHALRPIPPKIPEEDPDWDHPGRNIDYPKPDPDEDSVQEFDPYNPGGGVDWPEREKKPPVTFKNNWERLKKDDPDEIDNRKHRIQTGLGEGEVWDKLNEGDEPEKTNSGASGDVFDWVVQSALGVLDNSEAQGHVGHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCV2</accession>
    <name>B7GCV2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_16455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184866.1">
        <property type="nucleotide sequence ID" value="XM_002184830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCV2"/>
    <dbReference type="STRING" id="556484.B7GCV2"/>
    <dbReference type="PaxDb" id="2850-Phatr16455"/>
    <dbReference type="GeneID" id="7198680"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16455"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GCV2"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="129"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="414"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="7">
        <location>
            <begin position="593"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="683" mass="75036" checksum="4BDF902D2B31C5BB" modified="2009-02-10" version="1" fragment="single">PFGKDLKRTLVQAGKLADQMGSTTVGSQHVFLALLEYSEGGWAVLVKMNVLDDTVTALDVCESLLQNMADQPDQARRELVTGAGGSGKMPTLTECGVDLTQQAEDGLLDPVYGRDDETRACVRTLIRRRKNNVCLIGEPVGVGKTAIAEGVAQILVDEKLCPARLKGHRLFSLELSNLVAGTKYRGEFEERLQSIIKEVTDPKAPPTILFIDEIHNLVGAGAAEGGMDAANLLKPALARGELQLIGATTIMEYRKYIEKDAALERRLQPVMVKEPSVVQTIDILQAVQSNYEKHHGVTYTSAALNAAATLSDRYMTDRFLPDKALDLLDEAGAIAHLEEPDEDVTPEVTEHTVAMVISEWSGIPMGKLETQEMDRLQALEGEMGRRVKGQGRAIRGVARAVRRARSGLRDPRRPVASFLFCGPTGTGKTELCKTLAETYYGSEKDMIRIDMSEYMEKHSVSRLTGPPPGYIGYEEGGQLTEAVRRAPHSVVLLDELEKAHGDVLNILLQVMEDGMLTDGKGRTINFKNSILVMTSNVGSRRILEVARSGRDSIVQKDHYLYAELAQVVKEELEREMKPELLNRIDEIIVFSPLSTGDLWMIAELIVAKISERALKEQKLELKIDRSVIERVMAEGSANADQFGARPMRRAAQRFVEDSLSDAIIQGFLQEGEGATVSLASKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD30</accession>
    <name>B7GD30_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184978.1">
        <property type="nucleotide sequence ID" value="XM_002184942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD30"/>
    <dbReference type="STRING" id="556484.B7GD30"/>
    <dbReference type="PaxDb" id="2850-Phatr50137"/>
    <dbReference type="GeneID" id="7198841"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50137"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_0_1"/>
    <dbReference type="InParanoid" id="B7GD30"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052745">
        <property type="entry name" value="G3P_Oxidase/Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720:SF1">
        <property type="entry name" value="GLYCEROL 3-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="437" mass="48419" checksum="E0BBE1AF394CD012" modified="2009-02-10" version="1">MASNDDVYDLVVVGGGIVGLAILRAATLEGWRCALIERESDLLSWASGSNSGIICTGVDATPGTLERALIRDSISRIRLFCAEMNVPNRPCGSLVCHWPWDMEDRLQKVLLESHEAGDTHACYLSADQVKRMEPNLNPDCLGAIHIPGEIVVDPWLFSIAFASHARENGASIFTNFCFDAESSQYNDGVWTICRVRESIDATRNVPDKLKAKVLVNASGVWADLIDRDICNETKFTVRPRRGQYQIFSSNYQTTITHPIQPIPTQRTKGVFVFSSLYDQVIVGPTALDQDSRTDRSIDREVANELAKNGKRILRELDLSNDQIGEYAGIRPGTDRRDYQISFDYSRRWISAAGIRSTGLTASLGIGHHVARLLQSVLPEPTVLSESMETTPLPPVPLLVEEFHNRSDGSVHIGGHDYKVTHPITRFGWEARTGLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD37</accession>
    <name>B7GD37_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_3366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184981.1">
        <property type="nucleotide sequence ID" value="XM_002184945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD37"/>
    <dbReference type="STRING" id="556484.B7GD37"/>
    <dbReference type="PaxDb" id="2850-Phatr3366"/>
    <dbReference type="GeneID" id="7198844"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3366"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331910_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD37"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="24553" checksum="31E388DA36710044" modified="2009-02-10" version="1" fragment="single">MTFDQVGGLDVQLEAIARRVLASRANPAAARRLGVSHVRGILLSGPPGCGKTLLARELARILGAREPQIVNGPEILDKYIGEAERRVRDLFAPAEQEYKVAGDDSALHIIILDEMDAIARKRGTMTSDTTGVRDSVVNQLLAKMDGVREASNVLVVGLTNRPELLDPALLRPGRLEVQLRIELPDKTGRRDILRIHTSQMRKAGGLSEKAVYLMEDLGENGLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD53</accession>
    <name>B7GD53_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185069.1">
        <property type="nucleotide sequence ID" value="XM_002185033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD53"/>
    <dbReference type="PaxDb" id="2850-Phatr50158"/>
    <dbReference type="GeneID" id="7198856"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50158"/>
    <dbReference type="HOGENOM" id="CLU_504802_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD53"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="60105" checksum="1995D35C48E00D49" modified="2009-02-10" version="1">MSTLRRTPSGHTHRRKLSRNVDNDTDLAVAASLTNATTPIHQPSPSRLSLPSSPLILNSTAMSDMALPFLDTDSQESKSASTSRGGPRCGALVVWLGRVRALPRIGRERLRSVPPRYRWAVFVFWVLWKVVVFCLVVYLVHPSEKGVARPQRLLYTVTSWHDTGFPRTTNGTAFATDTDAAPSFDRFRHRVVPLLVANVQSLTIIKDWDVHVVLITAYPISPSQRSFLSEWIPPHVRWTVWDGACPLGYSHDDDRTLRENCHALARQHRYVIKDQLLQHDVFIALDDTVRVTARHVQQYLRLSHELEDWRSAVSGPVLGTDGAVTTTVLSKHQLDRLAPVVIPVQKRGNESRGMPRLRASSDVEPCCNHGNWDPGDELTSSRDYVFQQSNLFQPSTLHRLRPAVDPPHNTTTASEGIFVLSNMDTPRLEFMRLSPFPSEPTLQLVRWDGDLCLGPLLPPWGETTFPKDGFSLNAEYWLGGFQTLAKIDCPWQRLVDFGHIVDHLWYQIESGYDRGHWTAVADLVRTWKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDY2</accession>
    <name>B7GDY2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185288.1">
        <property type="nucleotide sequence ID" value="XM_002185252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDY2"/>
    <dbReference type="PaxDb" id="2850-Phatr50384"/>
    <dbReference type="GeneID" id="7199200"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50384"/>
    <dbReference type="eggNOG" id="ENOG502RZE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060657_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDY2"/>
    <dbReference type="OrthoDB" id="443672at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855803" description="peptide-methionine (S)-S-oxide reductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="6">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="29337" checksum="37903214FC64C246" modified="2009-02-10" version="1">MIQFPFFSTLLLFSATTALTVLPSESGFRPETSISRRVVLATLLGTAAATPFAAQVAHAADDEAVYFGAGCFWHMQHEFIQAERDLLGRDLDTQLSATAGYAGGTKTDGQGRVCYHNFQNVADYGRLGHGEVVGLTLPSDKIAEFGKVYFSLLDPKTKDRVDPMDRGAEYRSLLGLPGGTSHPAYPGIQEAAEAAGVTLKRGQGNDGDTLGKKLVWVYDTQTFPFYQAEVYHQYHNDFQSAPYGKAYNQMGSQAFEDGRLKLTGCPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE27</accession>
    <name>B7GE27_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyrophosphate-dependent phosphofructose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PFK_1</name>
        <name evidence="12" type="ORF">PHATRDRAFT_51286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185307.1">
        <property type="nucleotide sequence ID" value="XM_002185271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE27"/>
    <dbReference type="STRING" id="556484.B7GE27"/>
    <dbReference type="GeneID" id="7199226"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51286"/>
    <dbReference type="HOGENOM" id="CLU_020655_7_4_1"/>
    <dbReference type="InParanoid" id="B7GE27"/>
    <dbReference type="OMA" id="VIHEEIR"/>
    <dbReference type="OrthoDB" id="40818at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050929">
        <property type="entry name" value="PFKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005301">
        <property type="entry name" value="PRK06830.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45770">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="563" mass="61107" checksum="F22DCDD7B1AD0D50" modified="2009-02-10" version="1">MNERRNRASWLVLAVTGGPLLLSVSSRCFVDAFSIASSVSSRSSAHIGDSSSVRFLFADECSLNTFDAEECIATAGYVRDPTEASSVDNVLVAEIETLRDKFTSFENVDAHVKTTNMIKYCRRREGKRLLASDTIAPSVNSRIANIEYNHLIEDRELVLVDTVRVPGMDKSSRAFHRAGPRKLLHFDPSLVNAAIVTCGGLCPGLNNVIRELVHSLHNLYGAQNVWGITGGYHGFHNPEYAPVLLTNEMVENIHHEGGTILRTSRGGFEIDAIVSFLRSKSISQLYIIGGDGTHRGAYKIHEACMEAGLNIAVAGIPKTIDNDIDYIDRSFGFVSAVEAAQASIRSAKTEAMCTVPNAVGIIKLMGRSAGYLATFAALGSGDVDLVLVPEVPIVLDGPGGVLPFLRQRVKEQKFAVVVVAEGAGEELLEATNVVDRGGNRLLPPIGEYMRDRIKEYFVEHGEEATMKYIDPSYTVRSVPANGADSLYCMELAQNAVHGAMAGYTGFSVGLVNNNVVYLPIPQLVASSPRQMSPCGTTWERVLAMTGQPNTTPYVRSEEQPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEI2</accession>
    <name>B7GEI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="8">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PGAM_4</name>
        <name evidence="10" type="ORF">PHATRDRAFT_51298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185492.1">
        <property type="nucleotide sequence ID" value="XM_002185456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEI2"/>
    <dbReference type="FunCoup" id="B7GEI2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GEI2"/>
    <dbReference type="PaxDb" id="2850-Phatr17086"/>
    <dbReference type="GeneID" id="7199357"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51298"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_1"/>
    <dbReference type="InParanoid" id="B7GEI2"/>
    <dbReference type="OMA" id="MLPYWYD"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853273" description="Phosphoglycerate mutase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="306" mass="34627" checksum="5B91472C36FE8085" modified="2009-02-10" version="1">MMLRSLVLALSWTVASAFTHQSTFWGRTAATNSRILSLSPPTDASSSALCMKYTLVLVRHGESTWNKENRFTGWVDCPLSEAGEEEAHKGGQLLREGGYHFDKAYTSTLKRAIKTLWIVLEEMDLMYLPITNNWRLNERHYGALQGLNKQETVDKHGKDQVLEWRRSYDIPPPDIDEDSEYFPGNDPMYKDVPKEDLPKAESLKLTEERFMSWWEDTLVPEIKSGTKILIAAHGNTLRALVKHLDNISPEDITGLNIPTGVPLVYELDEELKPIPHKDAIAPLSGHYLGDQEEVRNRIGAVAAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3M5</accession>
    <name>B7S3M5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999261">
        <property type="protein sequence ID" value="EEC42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176168.1">
        <property type="nucleotide sequence ID" value="XM_002176132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3M5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1155"/>
    <dbReference type="GeneID" id="7205090"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1155"/>
    <dbReference type="HOGENOM" id="CLU_981641_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3M5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31615" checksum="DAB02D454F90BC6A" modified="2009-02-10" version="1">MTFTSICTATPHNANDLTEPLLPQGSGVKAPPASAVIGRNGEDDRDPDTTIVESNESYHKDDTDDPACSCTISMGLDRDKLPHQHQHKYRYKQSHTNSGDVSVVTCQDTTFLLLIFPALIAIQFGIVFWSISNNNNTTNSESTSVPKITVALVDHWPVVNATIALFAISTWLYRLTLQECRVTNVVLLLVPEILLNIVLGLVLFGQALWGFTVLLVSLLALCSLVVLHGVYQLFCDTRDVDDVVELRDDEMYHGEQPKVNDKKPESQDEEEDYGYYCRCHAIVC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0G4</accession>
    <name>RK27_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein bL27c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L27, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl27</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874439.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0G4"/>
    <dbReference type="SMR" id="A0T0G4"/>
    <dbReference type="STRING" id="556484.A0T0G4"/>
    <dbReference type="GeneID" id="4524562"/>
    <dbReference type="InParanoid" id="A0T0G4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_bL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000276456" description="Large ribosomal subunit protein bL27c">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="83" mass="8914" checksum="3E95A863C4337FCC" modified="2007-01-09" version="1">MAHKKGAGSTKNGRDSNAKRLGVKRFGGEQVTAGNILIRQRGTKFKPGINVGCGKDFTLFALTNGIVKFDYANGTQKCINIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3P9</accession>
    <name>B5Y3P9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65347.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr46762"/>
    <dbReference type="GeneID" id="7204528"/>
    <dbReference type="KEGG" id="pti:PHATR_46762"/>
    <dbReference type="eggNOG" id="ENOG502QWFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574250_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3P9"/>
    <dbReference type="OMA" id="CTGAPLE"/>
    <dbReference type="OrthoDB" id="74158at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="215"/>
            <end position="235"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="241"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="303"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="461" mass="49583" checksum="A5B998E7F877D84D" modified="2008-11-25" version="1">MNKNEGNLDASELDALLAHLPQEDLLEALGDEAEYESSSRPGHRKAQSLFVFPTGQRKRGRHHRHKSSMGQLFDSISGELLSIAEGVQAEAQVLKGTFREELEDADRGKTFFLDMSMTRSMSVLPEDIQDLAEEATGVQQQDGAPPDASVAGRYASLFTAVLAVSSNGTALALLDGVNPALKLQWRMTATALVLSFFASRTLLKEGFPKLSTLQLFTLMGAIICFFFMTLLLYTALEYTSIGNAVIGANSQALLLILGKFLVGQKVLALEGLGVVVAFGGCILCSGDEASDLNDEKKASTALFGDMLAFASAAAGVLYLTFAKAVRSEISVTVFMFLVTSCGSLLTLFYLILSGADLSWSTDPHIGAFGWINLSGQRLWILIHVALVCNIMGTMGFVRAMQYFDNIIIAVATLLEPLTATLIAYSLHVGDLPGPLGWLGNTLVILGTLLVVYPSIDKPMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3V4</accession>
    <name>B5Y3V4_PHATC</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">PHATR_46813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185905.1">
        <property type="nucleotide sequence ID" value="XM_002185869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3V4"/>
    <dbReference type="STRING" id="556484.B5Y3V4"/>
    <dbReference type="PaxDb" id="2850-Phatr46813"/>
    <dbReference type="GeneID" id="7204674"/>
    <dbReference type="KEGG" id="pti:PHATR_46813"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658007_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3V4"/>
    <dbReference type="OMA" id="ECCKLEM"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053772">
        <property type="entry name" value="At1g61320/At1g61330-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145:SF28">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145">
        <property type="entry name" value="OS02G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="418" mass="47101" checksum="5BF4E7313620BC08" modified="2008-11-25" version="1">MDAEKVVAHPFCQKTSDSAVQLDVLPRDALDVILSFLELDSYVILRPLSKQLRESVRNASHLRFPESDVLNGGFRKRFVNFSSYRPSSTSLTKLLHSFASLTELHLNTVHVLGDDLVAVLNAAPAALTIETMSIADPNLTYWCTDPLAFPRLRNLRFARGSIRSSLSLLLRETRNLKCLIFEHCCPIRDDQVRAVASLLGDSLVDLKLLQCLRLQSPVLRFSKLTRLSLMGCYHLEKLPEFACPALRYLNLSFIFRLTSAQVQTVLASLPCLRELIMTKCPSLSNLSVVSSSLEILDVQFCNNLHALRLRCPRLRQLDTHGCDGIQTLIVATKALENLSVAGLPVRRLEIYAPFLQTLNVSGCRRLDHCVIRCSRLETVHYHGSRLVALRFCKEVRKVILTRWSRSPVVPLRLPPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y417</accession>
    <name>B5Y417_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_46869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185761.1">
        <property type="nucleotide sequence ID" value="XM_002185725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y417"/>
    <dbReference type="PaxDb" id="2850-Phatr46869"/>
    <dbReference type="GeneID" id="7204719"/>
    <dbReference type="KEGG" id="pti:PHATR_46869"/>
    <dbReference type="eggNOG" id="KOG1934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002359_4_0_1"/>
    <dbReference type="InParanoid" id="B5Y417"/>
    <dbReference type="OrthoDB" id="190529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="856"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="335"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="956" mass="106063" checksum="09C047A9CFBF45CB" modified="2008-11-25" version="1">MTTTPENPPVPRTEAQKDSVIFATPEIVEDPHRNDPVLHIASDSKPKTTKTNVTQNAEENLTATTGGEGKGFSARWTGAINTIHGPIMKGLLWTSGTAARNPRKTVAGVTFLSFFLLIVGFLTNFSVDVDEDVLWTPENARPVKQGAWISTAGYPEENRDMLLFFHANTENVLGQAQTRKVFTALDTVRNLPGYRALCAQSSYVDPRTGQRTCEISGATAFWNDTAALFESQVDNDNDAIQQLSAPVYPDGTPVSDNDIFGKPLRNEVSRTLESAQAYVLVIGLPDTEETEDFELEALDAILDLRNNIWNGNEFNVEVTTQRSFPDEFTRGIVRDIPLVPTVFIIMSIFTCIVFAKRDKVRSRSLLGLSATICVLLSIMSGYGLLFIAGVPFTSMTQILPFIIFGIGLDDAFIVSGAYERTDPAKNPVDRIEATIEDVGASITLTTITSTFAFGLGASSDVPSVYWLCYYAFPTVMLVFLYQITFFVATIVLDEERICANRRDCCIWVTVQKREGTDEDVVSDVSHTDIAETVNDTRVSPVDYWMGVYSRQLLRPAVKVFVVLFFCGLLGACAYSATKLTQEFKFTEVLPDDSYLSAFQFAFDDNTFRSAVAPYAYFRFVDQSDPMIQAQMESYVNELVSISAIEEQPSFFWLRDFQQYRNETGLTNTNNTMFASQVQSFLSTDVFAALYQDDIVLDDTGNIVTSRVRLNMDNVDLEDVNEQIKALDDQAAVTAAQPVNQQGADWSFFSYDSIFNIWEFYAASVDEVIFTTVMGISAVTVLTLLFVPHWTAALFILPIICVLYIDLLGVMQWAGVHINAVSYITLVMSIGLTVDFILHVLLRYYESPGNREEKTLYTLQTMGTSVLIGGVSTFLGTLPLAFSTSEIFYTVFVSFIGLVTLGCGHGLILLPVLLSTIGPEDQIWEVENRAPATEIHEALVTFPASEEDKVGKELDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y475</accession>
    <name>B5Y475_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_46922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185959.1">
        <property type="nucleotide sequence ID" value="XM_002185923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y475"/>
    <dbReference type="PaxDb" id="2850-Phatr46922"/>
    <dbReference type="GeneID" id="7204453"/>
    <dbReference type="KEGG" id="pti:PHATR_46922"/>
    <dbReference type="eggNOG" id="ENOG502S0D4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025546_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y475"/>
    <dbReference type="OMA" id="CIYDEEM"/>
    <dbReference type="OrthoDB" id="1861862at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469">
        <property type="entry name" value="OS07G0633600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469:SF8">
        <property type="entry name" value="OS07G0641000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="72320" checksum="11B79FA851CE6AA9" modified="2008-11-25" version="1">MARAVGISVSGSSSVKASGGSSGGREGPKHSSSWTYTQILTSLLGTSVLLISLFNIYQVHRSSDALLQSKADQSVNNVLKDFMEMKPSNPNPFTSDRDEKGTVHQVSVAQYDRMHEADEGEPIERDYSGAEESDRSTLAGLSCADHGGPLDEFAREMVYWQDISSDSQYTSPFRSKSGQPRRYMTFEPDGGGWNNIRMAMETVLGLGIAMGRTVVLPPEQRMYLLAKDRGRQKTDFGFADFFPMHELATENAGLEMITMQEFLQAEAMTGNLRDKHTGQISFPPENRTDWDGQDVKPLKEWLHNVTHTPFWAPEKCMAAFPASGNHKDVEVLKSMLEQIQKDGGPLQEHVLENPTPVDATPIERMRENLARRKELCVYDETMQKEPVVHFMCNHRLRVRMLVHFYAFLFFEDWREDLWMKRFMRDHMRYIDAIQCPAARIVHALREYARQKDPVNNPRGDFDTFHVRRGDFQFKRTRISAEDILSNTRDELTEGAVIYIATDERDKAFFDPLKQFYDVKFMDDFKNELANVNTNYYGMIDQLVASRGQKFFGCWHSTFTGFIARIRGYHSVKDNLAGFEKGTLPTTFYYATLANKYVMHEYAPLHGAFFNREFPISWRDIDKSVGNLPISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4E8</accession>
    <name>B5Y4E8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186280.1">
        <property type="nucleotide sequence ID" value="XM_002186244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4E8"/>
    <dbReference type="PaxDb" id="2850-Phatr33124"/>
    <dbReference type="GeneID" id="7204255"/>
    <dbReference type="KEGG" id="pti:PHATR_33124"/>
    <dbReference type="HOGENOM" id="CLU_000850_0_1_1"/>
    <dbReference type="InParanoid" id="B5Y4E8"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="773"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122734" checksum="B57BD94FE7CE9F35" modified="2008-11-25" version="1">MDPLEHVLVNLLGATTLDSSYRRFFEEYGITQASELASITEHCLAMVSYGVLTPAVGDGPASIVRTFLPPAQQDRILKIVQWFLLKGTNVTNNTWLELTSDVLEYWQPASAIVAPATPVGSDARSSFAESAAAKFRKTIKNHSVPYPKFSEDRFWVTWNTNIRIKLRIHGVQFVLDPDYLPQTVDEMDTFVEMQNFVFGVFNDILLTPRARGILHKHVDELDAQSVYRDLVASYGKGINAQITATSIETKLTLYSFATSKSKTCVTFLTTWRNLIYDLERINKFPLPDHQKSVRLKSAVRSHPQLKLFLGNVQLYSCTHVGKSSDDSDFEYVYDLMLEHATNIDQTDFEDRGNNRGGRSANNAKSQSSSKKKTNKPLGKKHKNYVPPEKWNALSPEEKRTIMDQRGPCPAAAPASALSVNAAATQPPPTVYVSDSTAVDNQSLASTQVPNAAASGHLLRSLISNSAARQPSNGATSDSFSVNGTTYRREVNHASVRYRLSTHDVSLTKDSLIDGGANGGLSGSDVTVISQSLSQATVSGIGNSELTNLRLSTVAGLIHTTDGPIIGVFNQYAHLGTGNTIHLCNQMRSWGVTSIVTSDGRFVIPLSVSGGLTYLSMQAPTEEDLDNFEWVHFTADNEWDPNGVSSLLLRPMMISVCSFLPTMFRDERFNNFGLLAHSTVVSRSPLNADVLQPNFGWVPSARISRTFENTTQFARADARLPLRKHFKSRFPAANVSRLNEIVATNTFFSDTPAADDGIFNHGGGGGRKSQFAHAFEDFICTHGAPNALLSDNARAQIGKQALQILRMYAIDDMQCEPHHQHQNYAERRIQEVKKMVNTIMDCTNTPPEYWLLCLFYVTYLLNCLAVESLNWRTPLQVAYGQRPDISALLLFRWFEPVYYYDPDHASFPSQSREKTGRWIGVAEHKGDALTYWILTDNTHQAVARSVVCSANVDNGLKNHRAANSSPDGGEPSNPKPIVLALSDLRNPAAINPSLFESPAFSPDELIAPDGQSHRALVARKIVDADSDNRQAIRFLLQIDEKDADEIILYNELCDLMEAQQTDRVTNGNVEGHFKFTGVIGHQGPLQPTDVNYKGSSWNDLVQWEDGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4P1</accession>
    <name>B5Y4P1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATR_10409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186045.1">
        <property type="nucleotide sequence ID" value="XM_002186009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4P1"/>
    <dbReference type="PaxDb" id="2850-Phatr10409"/>
    <dbReference type="GeneID" id="7204345"/>
    <dbReference type="KEGG" id="pti:PHATR_10409"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339957_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4P1"/>
    <dbReference type="OrthoDB" id="441412at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="5"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACI65515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="40212" checksum="6C93C6BA627006CF" modified="2008-11-25" version="1" fragment="single">CILNFSLNKLPYTAVMFFIGTVMGIGAELLDDSEDQLNESIRLWIPIDSEVLLLVFLPGLIFKDSLGQNVHLFQKSIVQLLIFAFPLVLAGTVLTALIAYYIFPYGWSFNLAMTFGSILSATDPVAVAALLEEVGAPPRLKVHIAGESLLNDGAAIVFFSIFVARYLFELGIEGVGEDVDWGRGVAMFCQKAIGGVCIGIFFGLGLLTILFLLKRRFNREENVVEVTATIAIAYIGYYVADAVWATSGVIATVTLGLMIKFLGRAMFNDAKLLEDFWTLVEHLLNTILFTLGGTVWAVIANGGKEKLFTGRDWGYLVLLYIFLTVIRAFLFASVYPLTSRIGLKGSPQETIFSIYGGLRGAVGLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Z6</accession>
    <name>B5Y4Z6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186094.1">
        <property type="nucleotide sequence ID" value="XM_002186058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Z6"/>
    <dbReference type="PaxDb" id="2850-Phatr33327"/>
    <dbReference type="GeneID" id="7204394"/>
    <dbReference type="KEGG" id="pti:PHATR_33327"/>
    <dbReference type="HOGENOM" id="CLU_872807_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Z6"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34732" checksum="A86ACC2323A956F0" modified="2008-11-25" version="1">MPATECCKPISVFLVRHGERADELLKLKGIQVPREDKLDPFLSSRGYEQARDSLSILIECMNKEGTARKIGVFCSPMRRTCGSALMLSATDITSYPALEWGFRGSVDDNTIPVIVLNGLSTCATQVKKQGPINKLVQEGKIPCADCPANDGSLQGPMVMAARSMLRHQPVYDCSYLPYGWVQFCSIEAKTGIVAPMAPRMSTAKIDATMIPVVNATAENLRLQDLPTEQDSWRDSLNLGIQWADVEGCNTVIFLAHREAILGLLDICGQSMESSLVSTPHCCIGSFVAISTGEGKVRWQAHSVVDYNSFDVGMIPGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5B6</accession>
    <name>B5Y5B6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_33450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186439.1">
        <property type="nucleotide sequence ID" value="XM_002186403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5B6"/>
    <dbReference type="STRING" id="556484.B5Y5B6"/>
    <dbReference type="PaxDb" id="2850-Phatr33450"/>
    <dbReference type="GeneID" id="7204029"/>
    <dbReference type="KEGG" id="pti:PHATR_33450"/>
    <dbReference type="eggNOG" id="ENOG502QVMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5B6"/>
    <dbReference type="OMA" id="FLHQADW"/>
    <dbReference type="OrthoDB" id="10262702at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07783">
        <property type="entry name" value="ASKHA_NBD_FGGY_SePSK_AtXK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF80">
        <property type="entry name" value="D-RIBULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="343"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="53833" checksum="B8AEC5D6D82F24DA" modified="2008-11-25" version="1">MKTSRGFSIPNNTPKGPSAALVRQFVGLDLGTSGARISIIEPAFTTTDRSYKEVYTQAVLWNEGAYDDPKAWMEAVTSLLQSANDDFGLERVASICVSGTSSSCILVDAADGGKVTRSPARMYDYDVVTSSIHTPTQEPVYGVRALQKLQQFAPDKHTCQSPTSALAKLLSWNEEKPLTSSERLCHQSDYISMNLLSSNKACGSNHNNVQVYSDWHNCLKLGYDVRQLSWPPWLLDCLHDAGLAQSVLPFTVVSPGEPMGTISADAAKRFGLPEHTIVVGGTTDSNAAFFAATGTRTAPGTAVTSLGSTLAMKQLSDTYVEDASCGVYSHRFPSVLLNDTMREAWLVGGASNVGCAALRQQDFSNEDLVAISAKIDPFVDSNLSYYPLTKKGERFPIADSTKEPVLEPVPESRNEFLHGILQGIADVERDGFVILGSLGATPSRPTLVLTAGGGSKNDVWNQLRQRRLREAFGDDSLKVDKAENVEAGFGAAVLAAGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5I3</accession>
    <name>B5Y5I3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186188.1">
        <property type="nucleotide sequence ID" value="XM_002186152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5I3"/>
    <dbReference type="PaxDb" id="2850-Phatr44152"/>
    <dbReference type="GeneID" id="7204081"/>
    <dbReference type="KEGG" id="pti:PHATR_44152"/>
    <dbReference type="eggNOG" id="ENOG502SRQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065488_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5I3"/>
    <dbReference type="OMA" id="NGWISTF"/>
    <dbReference type="OrthoDB" id="44178at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="270" mass="30584" checksum="43EA11FEAB9AC9D0" modified="2008-11-25" version="1">MTSIESPRKMVQVVAPCTMQAGYTFMTQYGDAVIPVTVPPGGVQEGQLFTIPFPSKGDLSSEITPFILNHSVADEDSQLGKWTDSLFDCFRYGPCHVHLLNAVFCPQLLMAQILTRLKMNWLGERSPDNEWQQTFRVVLLMTLSYWTVYALLAPPSPIWIQDEQGRIVRLPNQQQVPALQVILYNLLSLLFGLYTLIVLTKLRRIIRLRYEIPVQFPRLGPWEDFCCAFWCGCCSVAQMARQTCEYDQQSSACCSPTGFGTSLHHPILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5S8</accession>
    <name>B5Y5S8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uridine kinase</fullName>
            <ecNumber evidence="5">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_10398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="5"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186518.1">
        <property type="nucleotide sequence ID" value="XM_002186482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5S8"/>
    <dbReference type="STRING" id="556484.B5Y5S8"/>
    <dbReference type="PaxDb" id="2850-Phatr10398"/>
    <dbReference type="GeneID" id="7204134"/>
    <dbReference type="KEGG" id="pti:PHATR_10398"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_1"/>
    <dbReference type="InParanoid" id="B5Y5S8"/>
    <dbReference type="OMA" id="PQSTVCE"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="209" mass="23654" checksum="93D4DB135A269902" modified="2008-11-25" version="1">MIPITIGIAGGTGAGKTTLARKLFEALGGEENVNYLIHDSYYKCLKHKSIEERAKTNFDHPEALDTDLLIEHVRCLKQGVTCDVPTYDFTTHSRTDETKPMVTRKIILIEGILLFCHPVLAKEMDVKVFVDADADIRLARRLQRDTKERGRTFEEVIAQYQKTVRPMHEEWVEPSKKVADLIVHSNGHSMVVAVDMLTNHLRCKANISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5V5</accession>
    <name>B5Y5V5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI66002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186532.1">
        <property type="nucleotide sequence ID" value="XM_002186496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5V5"/>
    <dbReference type="PaxDb" id="2850-Phatr33641"/>
    <dbReference type="GeneID" id="7204147"/>
    <dbReference type="KEGG" id="pti:PHATR_33641"/>
    <dbReference type="InParanoid" id="B5Y5V5"/>
    <dbReference type="OrthoDB" id="44133at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI66002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="263" mass="29101" checksum="073B4AF3F4AA62ED" modified="2008-11-25" version="1">MALRYLRTKPLCSPLRPPSHSGLLPSCAVNATPDPYHNGTAPALLRGAPGTTRLPICIDPKEENHCDVLQQTMLVAKHKRAQLEQQYVSLMAHYVDVAQALQHATQNQQSPGNVLDAGQNTASLTTVVVTEEEDKSEVVDQLRDTVTALSNELEQGQAQNAAIASKLWESCLAQDKWVAMMNILRQETEGILHRRNVLLESDVALERLAAKELARKGQTKTTDPGWTGRVWSLRKSPRRRHQPAKRTKPMMGGQRGQSGRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNU3</accession>
    <name>B7FNU3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_42585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176595.1">
        <property type="nucleotide sequence ID" value="XM_002176559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNU3"/>
    <dbReference type="STRING" id="556484.B7FNU3"/>
    <dbReference type="PaxDb" id="2850-Phatr42585"/>
    <dbReference type="GeneID" id="7195961"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42585"/>
    <dbReference type="eggNOG" id="ENOG502R8V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617479_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNU3"/>
    <dbReference type="OMA" id="EWWVQVK"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19671">
        <property type="entry name" value="UBR-box_UBR4_5_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="444" mass="49272" checksum="0392662F6B692441" modified="2009-02-10" version="1">MEKENVSDSEQLCCTFAVTGESESFQSIFICRTCSLDAKDLLCVCQACAETCHEDHEGLEYVGIGPSYCDCEALLEGGCKIIGRSAKTAHRLGIFKTVFENSITKRPTGEDGKYVQQTFSIPALDDDDLCSALCLQSEELVKHSKETFWLDASTDLEHCCLLEKLAWHIYRNQINEYKLQGDDLAGGAEWWVQVKSVSLPEINGAQTDPDAQGNEAIDIHFDKDEALAEAFGLGAFPLLSTVTYLTDSPYSPPTIIFPREYGESDDAPISEVFVSRPRKRKHLVFDGRLLHGAPSHFGLRPQRRPSSKCGIGPRITFLVNLWAKHCPAGVSPLPETIRCRIVDLAPSDLRVFPNMFENSGFHRMGTDIVHLDESTESKYNESSSSMIELPFLGKGTTWESSDSNDELSTNVFVYPPPDVESDTYIVRFGSGMEGFIDVSSETQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNY7</accession>
    <name>B7FNY7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_31649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177122.1">
        <property type="nucleotide sequence ID" value="XM_002177086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNY7"/>
    <dbReference type="PaxDb" id="2850-Phatr31649"/>
    <dbReference type="GeneID" id="7195983"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31649"/>
    <dbReference type="eggNOG" id="ENOG502SG9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048643_2_3_1"/>
    <dbReference type="InParanoid" id="B7FNY7"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28908" checksum="484D0770FA516532" modified="2009-02-10" version="1">MAAPVRDLRQALLKGSLGPLNPFPWTMQTGNCLGWVIYGYYTRDPYVVAGNLPGLILSIWLNMGAAKLQYLDIHESQKAHQHQRPSQEHWDASSRTESQEGLDEVPGLFQSEEELVVAPQERALLRILAGWAVVATYVGWFSKDDAAAVVGVVVNANLIFFYGAPLQTLQQVITERNSESIHLRTMFMNWTNTSFWIAYGLSRRDPVIILPNVIGLSLGLIQGVLCLVYPRQTHDLVADLEPLTSVASIVASGEVAPSSPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNZ4</accession>
    <name>B7FNZ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176618.1">
        <property type="nucleotide sequence ID" value="XM_002176582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNZ4"/>
    <dbReference type="STRING" id="556484.B7FNZ4"/>
    <dbReference type="PaxDb" id="2850-Phatr42625"/>
    <dbReference type="GeneID" id="7195989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42625"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011791_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNZ4"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="393"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="502"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="77880" checksum="B8C930095C1864FF" modified="2009-02-10" version="1">MQANWELSQSLTCDGQGIRCACVLPAPDGTADGFQILTGTQGGSLVAYGIPSGNLESSAYRHDNAVTALATNATGTHYFTGYKDAVVRVFDVQHNLIAQLKGHDKAVTSLAYADGGKDGEFLISGSWDGTAKIWRLANSSLVATLPNHENSVCVCVQGVDTGGMLHIATGSAGLAQNNTIQGHSIRIWTVDVRITSDVKLLHTVANDHDGPIRDLCLAPPDASCLASCSNDGTVKLRVAETGDVLTTLTMLTSSHPPMLLSVATTTDQSCIVVGAEDGHAVVWDLSATERSPQILLHAQCVWSVVPLPNGDFATCSDDGVIRIFTHCTERVAPLAEREAWEAEVAATQQKKSNGPSAEEIAALPRWDQNYEKRGRSEGDVRVFQKNGVAIAAQWSAASQTWIEVGQVTGSNENTGTLNGVQYDHLLPIEVDQSGGGVAKLQIGYNNGENPFVAAQRFIDDHVLPQHHLQDIANYIQQRAGQQGPTIGNDSTVASGSPMVSYEYLPAPGYKQFGLPVKTASTTLAKVKSKIIEFGLLSDIDVEHLTHLLDTLSASSRYHSSKILDEELAVMEKMLSWQQPSQVFPALDLARLVLLHPDAASRERYGYWSRVVPKTIAIMAIESVEGPAAVAIPMLGLRLFSNGLKGGPGSCEAIANNVDAILEVTTRLVPSSNKNVRLALATLLYNTACYVRSNPGTDISDKFFPILWLALTQKKQRMHLSCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPQ6</accession>
    <name>B7FPQ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_31925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176752.1">
        <property type="nucleotide sequence ID" value="XM_002176716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPQ6"/>
    <dbReference type="STRING" id="556484.B7FPQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr31925"/>
    <dbReference type="GeneID" id="7196493"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31925"/>
    <dbReference type="HOGENOM" id="CLU_1191896_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPQ6"/>
    <dbReference type="OrthoDB" id="202518at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855256" description="GST C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="24953" checksum="6A6CBBD1AB47A83C" modified="2009-02-10" version="1">MAPFLSICRLLFVPLMSFTLIDLANKPAEFETKYATVSDERSKVPLLEHNGKIIIESEVVAKYVAVNIVGKNDIDLLGDDSEVEGFLKVWQPVQLAFTNTLRAKNDDEVKVAIDSFFQSIEELENYLDPTTVFVCKSFSLAECLVAPWVHRMFLTLEHFRNIKLGNMLTPYPRTALWMTAVRDRPSVQASAIPMDKLLPSYRKFFVTYVTPGAPAASAESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPR5</accession>
    <name>B7FPR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_42841</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177259.1">
        <property type="nucleotide sequence ID" value="XM_002177223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPR5"/>
    <dbReference type="STRING" id="556484.B7FPR5"/>
    <dbReference type="PaxDb" id="2850-Phatr42841"/>
    <dbReference type="GeneID" id="7196438"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42841"/>
    <dbReference type="eggNOG" id="ENOG502RRBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310468_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPR5"/>
    <dbReference type="OrthoDB" id="48940at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="639"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="784"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC51722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="915" mass="99087" checksum="D4ADBA4FA75EC48C" modified="2009-02-10" version="1">MARFSLTNVNSDEEETLNGVDVELEYSSDDDDEEDEPPHPLGFRSSTRISLHSPTETMEQYKRRWGYFYPIDDAHDENFFDTPIDSKIQSFPPLSTYMNPNTVSTRALIGYANERKPTDDCVDQVIQLLQAAALVDERDLTTPLLLATNTHLDATNRLTQQKLIEIQHEIDVERRRMERDHLEAAEALQLILHRNQETAELISAEQRRLDSVAQEGEDIRARADKEKQTALKDEERQKEKDAQENAKRENLDSQRAAEKEEAVRSSKYEFIAKAKKLVAQLVLIRASVESFEKSKAVGKRRLQMKKIVNGKVNTLSENTQKIREVANNVSQAIEKARDEDKQAKEQGEEGNKGFLPEMARGKRYFVDLLSSKVIVRVQAEGFNGQRGDGFPLANMLAQVSTDHKELGPNLAAHIYTVCPTAIPSLPDPAPDASEDDLMRSLGMLQHADGNFESFERFLGRTEGIISMVANIMSSSPANHTLLGGHEGAVKWMTRFLSLLPSSTDTALPLIVAPVLDAFLTGAGHMLANIHAEEFKLLLKAIDENVLPRLDDGPTGKPSAMRLEKTMSGGYEKFQSTLPSRALAEFYNGSSFLRSHGSTSTPSPFGHSVFAGNAGTTGVPPFGQSSTNSLVEAGTSSDAFGKPPLNASPFTGSGTTSHTTSGISKMDQSDSFQPKQTQALPFGVASNTSTFGQVASSSPALLQKSSPFGNTFPSPSPFGTAASVPFGKPNAVPLSVSAPNPSTSPFGNSLQTVVPFGGQNMSLPSSGSSIPNTFPFGNPAQAASPFGKPTPMLSSYGISHPNPSPFKNPSSGSSPFGSVVASSSPFGGTSKVISTFNSGSSSPFGSQTGSSSPFPSVGDFPPNSNGRPSHTTKTQPCKFFAEGRCRFGDNCRFSHEPPNSTRIPSSSPFMNTTFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPR8</accession>
    <name>B7FPR8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177261.1">
        <property type="nucleotide sequence ID" value="XM_002177225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPR8"/>
    <dbReference type="PaxDb" id="2850-Phatr42845"/>
    <dbReference type="GeneID" id="7196439"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42845"/>
    <dbReference type="eggNOG" id="ENOG502T0EM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740735_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPR8"/>
    <dbReference type="OrthoDB" id="47659at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="423" mass="47961" checksum="A1D43B3A1D6EDC75" modified="2009-02-10" version="1">MDLCFGTKRSRSECHTETKRAKLTDHQDEVMPRGRIAWRGSHVSLEQRPMPLDQDEEPPNTGKIAPDPHDRSACFSNSTLAKRKSTDPDESEHNKELQLRWDKYSDDRNLDSSRLTGSPDSNFGLFLYIPPRLSAANLPRIQSEEACLLNSAPVPKFIESLQTPPRETLRCYMSSLVNCVYHGDFFRKRLSRTEFTLRALFTLIVALTLPSVMFALATKDFMEQNSVYVPGGGFSGFWFTLGRLQSLPTPTSMNYYCYSAGCLGVVATLVNRSMNEMLDSALEIQSKWDHAEISRFSVVPLFLDDLLQEPNPLSENTDLLSLVHIITSVKAGWFGLKPVTRTPLNYVELREMLIQTTWIPLVVGDDVWYLDHMDGAFTMKHHPTCDFQLGVPFIPSILLNTINVNLGRQKASAFWEYGLKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPU1</accession>
    <name>B7FPU1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_9070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176768.1">
        <property type="nucleotide sequence ID" value="XM_002176732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPU1"/>
    <dbReference type="FunCoup" id="B7FPU1">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPU1"/>
    <dbReference type="PaxDb" id="2850-Phatr9070"/>
    <dbReference type="GeneID" id="7196512"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9070"/>
    <dbReference type="eggNOG" id="KOG0879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="B7FPU1"/>
    <dbReference type="OMA" id="GEFLQNE"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="192" mass="21096" checksum="3A28B03BCBF772CE" modified="2009-02-10" version="1">MASTSPDPTVMEAIERGNVVVFFDVSLGESGDNETPLGRIKIELFQQDCPKTCENFRQFCTGEFLQNEQPTGYKNSIFHRVIKGFMIQGGDFVNHDGSGKMSIYGATSFPDENFLHKHDRPGLLSSANSGPNTNGCQFFITCGKADWLDGKHVVFGQVLDADSMLTVRKCEAAPVNGSEPRLPIRIVQCGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQP7</accession>
    <name>B7FQP7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycolate phosphatase, PGPase</fullName>
            <ecNumber evidence="2">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GPH</name>
        <name evidence="2" type="ORF">PHATRDRAFT_43120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176905.1">
        <property type="nucleotide sequence ID" value="XM_002176869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQP7"/>
    <dbReference type="PaxDb" id="2850-Phatr43120"/>
    <dbReference type="GeneID" id="7196892"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43120"/>
    <dbReference type="eggNOG" id="ENOG502S1S7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_0_1"/>
    <dbReference type="InParanoid" id="B7FQP7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852528" evidence="1">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="31521" checksum="7DE59DC89BC382CF" modified="2009-02-10" version="1">MLPSFMIPRSFLLYCLWAQQTISSFPLHSTTPQTISSFRSFRLPASSVPAANDDANNSMYQNIKGIIFDVDGTLADSWKLGYDATVVILDKHNLHPITEQIYHEHTVYCTPERLARHAGLVPGDETYAEVGAKLGKEFDDLYVGLVSSQTAGFYPGVAECLQAIPSDIAFGALTNAAVNYAHAVLQVNDQNKNLVNRFVSIHGADSVPEPKPSPAGLLQVCRDLNLRPADCVYIGDSPSDGKAAEAAGMGAIAVLWGSHKEDTLKQAPFTHYCRTVQELQALLPKTSAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQV6</accession>
    <name>B7FQV6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precursor of protein zeaxanthin epoxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZEP2</name>
        <name evidence="7" type="ORF">PHATRDRAFT_56488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176935.1">
        <property type="nucleotide sequence ID" value="XM_002176899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQV6"/>
    <dbReference type="SMR" id="B7FQV6"/>
    <dbReference type="STRING" id="556484.B7FQV6"/>
    <dbReference type="PaxDb" id="2850-Phatr5928"/>
    <dbReference type="GeneID" id="7196921"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56488"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_16_2_1"/>
    <dbReference type="InParanoid" id="B7FQV6"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="BRENDA" id="1.14.15.21">
        <property type="organism ID" value="4707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496:SF1">
        <property type="entry name" value="ZEAXANTHIN EPOXIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855311" evidence="5">
        <location>
            <begin position="20"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="396"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="604" mass="67014" checksum="E8C911F09FE0F465" modified="2009-02-10" version="1">MGLSFLSLCAVLTASSAMAFVTTRSPACNDVTRSLHRINTRHMTYPFYPASSLRISTRVASTAVPPEDVAFDKLSLPAREGRPLKIAIAGGGVGGLTTALCMLKKGFDVTVYEKTAAFARFGGPIQFASNALSVLKEIDETLFERVMDKFTFTGTRTCGIKDGLRADGSFRMTEDRLDYLWNPDAPADWFVKFPLKQCADLFGLPYTGVIDRPDLQEILIDECRKLKPDFLINGNPVVGYEDLGKGQGVTINLNDQTTASADVLVGSDGIWSAVRDQMYKEGGVKSTSANKKKRQGCDYSGYTVFAGETILKTPDYYATGYKVYIGPKRYFVTSDVGDGRIQWYAFFALPPGTKKAPSGWGGSTRDGQTDPEENLVDYVKGLHEGWSDEVMMVLDSTSPDSVEQRDLYDRAPELFRSWANGNVVLIGDAVHAMMPNLGQGGCQAIEDAYVLTETLANTRTTEKLQDALQEYYRKRIVRVSIVQFLSKLASDLIINAFDTPWSPHDNLGKSWKSYLTFFWKPILQFAIFPMQFAYLYSYYPTGNMGDLPAKLEAIWKEKHKTDAEAVFEQASKEGFVMEHEASFFKKAEVELSPTALAATKEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR37</accession>
    <name>B7FR37_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Violaxanthin deepoxidase-related, chloroplast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VDR</name>
        <name evidence="4" type="ORF">PHATRDRAFT_56450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177513.1">
        <property type="nucleotide sequence ID" value="XM_002177477.1"/>
    </dbReference>
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    <dbReference type="STRING" id="556484.B7FR37"/>
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    <dbReference type="GeneID" id="7196960"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56450"/>
    <dbReference type="eggNOG" id="ENOG502QUXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033125_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR37"/>
    <dbReference type="OrthoDB" id="420426at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010028">
        <property type="term" value="P:xanthophyll cycle"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calycin"/>
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        <property type="entry name" value="VDE_dom"/>
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        <property type="entry name" value="OS01G0716400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC-RELATED"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854908" evidence="2">
        <location>
            <begin position="24"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="VDE lipocalin" evidence="3">
        <location>
            <begin position="296"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="587" mass="65375" checksum="3A7504AC760A5EF0" modified="2009-02-10" version="1">MKLHRKGRYRLLVTAVLLGTVCSFVPENLRSGSVRIPRKNANAGSVPGTHTVSKQPSASATRHKVSQTSIDANALPIKNDLIQGPVSANKSIGSITFLLPSSGADEIKTNFGSSSPVGNPSLDEAVRHLANKSQYFSDGRVETRIVYVPIEEQDESVWKDLLETDVLLAMGLQYEADLAFARKLFQQRHDRDAEHRFRQCHFAIDCAQSFPTMVGPYDSENPSFRAKLLPWTKHASGKRLSQQMVALLQRGNSDDFVFAIMLFLNQFSGSSVDWVKHSIDATWEKGPLRNAQEVVSMVSKCGDCVVKCVQDDNCRECLEVLTALDTRDQVASYRTIVSYESDLLKDFSFCILQKNNIFNCDASLPTLPNVQPVATWREQPLTEDIARSLLVGHLNDEAAPESSLRTDISWKVACGANEAYDKFPSQNQLFYPAARGRDLWYDPVFRVETLDGRNVWCKRHYKVRPADIPGTFRFSVLDNGITSNEFWTIVGVADDLSWIVFHYAGAASAVGQRYLGGLLCTADGSLPDESQRPEIWRVLRSAGIQPWDLYTVNNDLTSPGAQEAGPPPLDYFRREVLAKRAASSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRY6</accession>
    <name>B7FRY6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_43350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177883.1">
        <property type="nucleotide sequence ID" value="XM_002177847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRY6"/>
    <dbReference type="PaxDb" id="2850-Phatr43350"/>
    <dbReference type="GeneID" id="7197397"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43350"/>
    <dbReference type="eggNOG" id="ENOG502S27S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_1_0_1"/>
    <dbReference type="InParanoid" id="B7FRY6"/>
    <dbReference type="OMA" id="VASFMTF"/>
    <dbReference type="OrthoDB" id="46116at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="36465" checksum="5AD0009B5123AF71" modified="2009-02-10" version="1">MSLKALLGGAMIGSASGVLLLLTGNIMGASGIASSALLKPTQLLTDQSQHWKLVFLASFLLTTNVFFSVPFDRSDPAAATLSPLGYGLAGLFVGFGTKLSNGCTSGHGICGLARLSKRSMAAVATFMASAVATTYLTQVSPLLTKFTSVLQVEAAQQTHSQPLLGVASALTLLSVVASAVAPWFRQKKDENGQARILPAIASGSMFASGLYIGQMVYQSRVLGFLNLAGMTDGSWDPTLVFVMGGGVMVSLLSYQFLEGYRITRSTTPVKHPLALKPDAPFCIPTNTHIDAQLILGSVAFGIGWGLGGICPGPGIFLAGAGVQNVILHWWPSYFVGTYIANEIQNQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSB1</accession>
    <name>B7FSB1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP2mu</name>
        <name evidence="11" type="ORF">PHATRDRAFT_18142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177952.1">
        <property type="nucleotide sequence ID" value="XM_002177916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSB1"/>
    <dbReference type="STRING" id="556484.B7FSB1"/>
    <dbReference type="PaxDb" id="2850-Phatr18142"/>
    <dbReference type="GeneID" id="7197526"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18142"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="InParanoid" id="B7FSB1"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="170"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="425" mass="48796" checksum="0BB0B0B2592217E6" modified="2009-02-10" version="1">MISMIMVLNQKGDIMISRQYRDDVGRAAADSFRLQVVAAKETGTEAPVKRIENCSFLYTRHLNMYFVALTRSNVNPALVFEYLFQLIKILKAYLGEEFDETAMRNNMTLIYELMDETMDFGYPQNCAVDVLRLYINLGTAKPQDEPEPSKLTSQITGAIDWRREGIRHKKNEVYIDVLESVNLLLSSTGNVLRNEVAGSVQMNTKLTGMPECKFGLNDKLVIEKDKEDRKPSVDIDDCTFHRCVRLGKFDADRTITFIPPDGEFELMRYRVTDNINLPFRIIPAVQESQNNTKVSIDLKVIANFSDQLFATHVVIKIPVPKNTSKTKIKHSFGRAKYEPEQQAIVWRVKRFAGKAQCIINAEVDLMPTVRSQPWSRPPINVEFQVPMFTGSGVHVRFLRVYDKSGYHTNRWVRYITKAGSYQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSB8</accession>
    <name>B7FSB8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177636.1">
        <property type="nucleotide sequence ID" value="XM_002177600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSB8"/>
    <dbReference type="PaxDb" id="2850-Phatr32681"/>
    <dbReference type="GeneID" id="7197174"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32681"/>
    <dbReference type="eggNOG" id="ENOG502RPC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060657_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSB8"/>
    <dbReference type="OrthoDB" id="443672at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855372" evidence="1">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="30485" checksum="23D77C43A2BF63DE" modified="2009-02-10" version="1">MRRTLTTLVVAAFVSALVEALTSDGIHHSETLSRHAFFKKVATTAAIVTSGSLSLGPNIAVATAGEEEDIAVYFGCGCFWHVQHELVEAEKTILGRSDNELTARAGYAGGTKGAKDGKVCYHNAAQIADYGKLGHAEVVRVNIPPSAFPLFAAEYCKLFSKEGYRADQWGDRGSEYRNLVGIPGGLNSVYAKQLVETSIKEGDKLDFAKGKGDDPDARALSFIMDTRDFPFFTAEQYHQFHDGFAAGENYPNSYNALASKYAKEGNLGNSDCPNGLLGIGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSD3</accession>
    <name>B7FSD3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177964.1">
        <property type="nucleotide sequence ID" value="XM_002177928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSD3"/>
    <dbReference type="PaxDb" id="2850-Phatr43480"/>
    <dbReference type="GeneID" id="7197182"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43480"/>
    <dbReference type="eggNOG" id="ENOG502RR8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859178_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSD3"/>
    <dbReference type="OMA" id="SRRVLWC"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="40782" checksum="34111C1BFCEB23AE" modified="2009-02-10" version="1">MASSCRSILRIGGADELSAHVLQTAVTDFFDQRLERNFELFQGQSNSQSVAPQTSGLDKDEHCITESLTANKTSPEAVCINNRYFSAHVHFRPIEHVAAADEKEDGIVLVWNSTTSMDTLSPIHDRAVDYGAGDLLRLCVYLNSTSPSREVVSEQAYADRVLFCLDRGYEYVSVNLNETQVGHNDRDKEGFARVVEALETTMWSSAVMAKTTQRRLQTSLDQTRDSVVGSFPDTKENHTDPTSVDESSYSAYEPPNPDLLTPLAVRDDPEGAEREDRAKQSLLSTIPALSATAKQHTGETNFEAEKTMNDLENALRDAARIREISQKGAMSDAERRQRAGDAALILMNLMGQFDDSEEEDDNSSNCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSN0</accession>
    <name>B7FSN0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178010.1">
        <property type="nucleotide sequence ID" value="XM_002177974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSN0"/>
    <dbReference type="FunCoup" id="B7FSN0">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSN0"/>
    <dbReference type="PaxDb" id="2850-Phatr43559"/>
    <dbReference type="GeneID" id="7197298"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43559"/>
    <dbReference type="eggNOG" id="KOG1423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433804_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSN0"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="391" mass="43970" checksum="0E2092815553F6DC" modified="2009-02-10" version="1">MRPTFIRTALVTFRWSGGPKISRSDRVRLSSTTIGSTPSLEDRKRLDVAIVGLPNAGKSQLLNVLTQSTVAAVSRKRHTTRDGILGARTVDDTQLYFVDTPGFLRQSQAKKEGLNRDLVVTASSEMENVDFSLLVVDAARRMTDDYEETLVALMLAALRSQGRLEFDVHSAEEVQSIRTPKGGTNPAKFAVVLNKVDLVHPKSNLMDLAVNIGTLAEQCIKFDAKESGKEELFLDSAYLQESLPMFFYISALKQRGVQDLLEFLLERATPSTSWEVEAGEATPMTMKERIEEVIREKIYRCLHKEVPHSIRQENRVLQQGKDEDGNIVLVIHQDLIVRSKSHQELVHGGGGRTLERIRETAARGLEKIFFCNVVLHLHVKLPRSKNQRWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSU9</accession>
    <name>B7FSU9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_43611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177728.1">
        <property type="nucleotide sequence ID" value="XM_002177692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSU9"/>
    <dbReference type="PaxDb" id="2850-Phatr43611"/>
    <dbReference type="GeneID" id="7197333"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43611"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544553_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSU9"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="50907" checksum="D94AD39CB86A5272" modified="2009-02-10" version="1">MSETKPLVPTTDDAVDHLRRLKAYQPWAFFITFGGYFMSHFSRKCYSTVKQQLQTQAGYSPLVLSEMDTIFMATYAAGNIINGKLGDTFNPTTILAIGLLGSGACLFLINVAIWFDFEGFSQTLGNFFILAVYFLFGFFQATGGPVGTAVMGNWFCDTGSVKNRGTIFGFWTCHQYMGDITAALCTAWVLGIGLPYWWALLIPAIANVAWAFLTAQLVADPYTVGIITPEVRIRQAKHEAKRKEMAELGESVAADEGPQPITYLAALKIPMVAQYAVAFGFFKLTNYVLFFWLPYFLGKAFDPVTANLIAALYSVGMMPGGIIVGYVSDLFGGRRAVVIGVFMCMLIVFLGVFAVYSEAGLSPGALLVMLGCMGILVGGPNNIITSAVAADLASHPSVLGNNKSLGTVTGLINGCGSITASIGLLAVGPLQESYGWGSVWLYLIFCTATGTLLMATKIYSELFPSAANATAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTI2</accession>
    <name>B7FTI2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178156.1">
        <property type="nucleotide sequence ID" value="XM_002178120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTI2"/>
    <dbReference type="PaxDb" id="2850-Phatr44262"/>
    <dbReference type="GeneID" id="7197989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44262"/>
    <dbReference type="HOGENOM" id="CLU_521264_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTI2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="523" mass="58393" checksum="DAA6D52BE605664B" modified="2009-02-10" version="1">MPSNVRDLLSRIGSFRHCKADRQQLGEESYTTDLHLGAFPLCLKQASLSSQSTRPGDFPAYLLEERVLDGVRESGFPVECDTSSKKDASVTEAIVLDSSERHKSQCSFAERGTKINSCPSRSRRRSSKIDDEALQKIRELVVRTTMNARSHRKVLRSSSYDGQRSSSECREFFKPSSEASRKASSNVVERRLQRHGSSRARESISSSSKDTGVKFFPELEVVPSKSEAASRKKLKEKVGRASTVRQGKMLHPSRGIFRSKSLNTNPGEEKRLDQSAHKTGTLLYDQRRSVNRTDNDLSVSDNEKNPSDVSERLQAARRAMRDLYVDEKVQIRSQAAPLSQSLHTGSHRGNHRHPSSGRCDHRRRHKENGLSQSMHVPKPVQGLKRRDEFVHHRCSNNGTKNSATYSSVLEDLVSVAAKSPGMLSSNTVSRLARQYSSGSSKSGAEAQKLPGRSRCSRSHHLREKPHIASLRSSDLKTTAPEYYQLDILDGSYHREHASSSVWSTVFHDDDSLTSAAEASDFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTX8</accession>
    <name>B7FTX8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_5546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178501.1">
        <property type="nucleotide sequence ID" value="XM_002178465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTX8"/>
    <dbReference type="STRING" id="556484.B7FTX8"/>
    <dbReference type="PaxDb" id="2850-Phatr5546"/>
    <dbReference type="GeneID" id="7198054"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5546"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_2_1"/>
    <dbReference type="InParanoid" id="B7FTX8"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="172" mass="19692" checksum="A0E8309AFB98092D" modified="2009-02-10" version="1" fragment="single">EEQAQYVAMDCEMVGVGALGTKSALARVVLVNWHGNVLLDRIIRPEQTVTDYRTFVSGITEADLAHAGDLESCRQEVKNLLRDRVLVGHGLKNDLAALSLRHPWQQTRDTAKYEPFMKIRFEDGVLWPRKLKDLCADKLRKTIQEPGIPHSPYEDAMAALHLYKRVRDKWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU57</accession>
    <name>B7FU57_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178540.1">
        <property type="nucleotide sequence ID" value="XM_002178504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU57"/>
    <dbReference type="PaxDb" id="2850-Phatr44450"/>
    <dbReference type="GeneID" id="7197742"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44450"/>
    <dbReference type="eggNOG" id="ENOG502SWJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878443_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU57"/>
    <dbReference type="OMA" id="HHALLVW"/>
    <dbReference type="OrthoDB" id="44565at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855014" evidence="3">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="34876" checksum="7871A5E6AF09ACCF" modified="2009-02-10" version="1">MRQFSIHHALLVWFIASLSLPWTAAWNTPLAVRPGISRQFLSSRPSLALFLSDSQKSSRDSSQPESGANDSDSEQAERTSFDDAGRSLIEEQDQERMDQMGDFDSNPEYQTDNIEKMRAAIRARTESMGIEKSKVSADYIAAKTKAATAAGSASAASENSDMFGGLDLSQINSEKTISKSEWNEDLPSMFYDPESELSKEEQEQVDPVMSKNLVEQAMAEFSNAKWPDFASALREVGLMLVVIAVTGALIISWDKVLRGAYMSLGFIPTADDLANYASRFDGLDLPKGWMDNMNEQDVARIAEKVNTVTGSKSLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUK3</accession>
    <name>B7FUK3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178334.1">
        <property type="nucleotide sequence ID" value="XM_002178298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUK3"/>
    <dbReference type="PaxDb" id="2850-Phatr44583"/>
    <dbReference type="GeneID" id="7197603"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44583"/>
    <dbReference type="HOGENOM" id="CLU_509504_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUK3"/>
    <dbReference type="OrthoDB" id="49650at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="535" mass="59853" checksum="0A25081843C33DAC" modified="2009-02-10" version="1">MPGIHRDLSGDSGNFSDDELLSILNQLGVQPRSSARHEERGMYLFSENRDSVARERPASAASASILARPSVPAKRQASLYEDLLQCQHDIGRAASNPEQQLISAWAESRPSTSTRVRDRPGRFVSDSRQSPLTVNSTKANKGSFRHPIPRDYFRRSDSSSNDNSSGSVAPTNWESTYKTKELSEVTSSSDLSNCSSLHKNSDPEDFSFRRSAYISECLSRVGEPSVLEGNFHERGDAVNDEVRAQQHILCKIQEEQERKMLELALAQSAADVVITTSQCHSRHTCNLNQRSEAMTQRPVSSIDLSFEQDQLELVLKLSEQESSVKHCNAGFQISEGEERLLQLVTRASGIIVSSSKTVDTEEEEQHMMQLALTLSKQEYQASYPTKPYQRVAFLPRELSLRDSTSGLLLDKLTTEETTINTNHHKDWSESAADTWKQSQSLALAEFKTMVGSTAFKDTIALAKYQVDDDSERTEMLRRGQLETIGAIRTGRAHVIECHGCNERLQAPIHYSLVYCISCGVVSPGKTAKFIWRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUU2</accession>
    <name>B7FUU2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178379.1">
        <property type="nucleotide sequence ID" value="XM_002178343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUU2"/>
    <dbReference type="PaxDb" id="2850-Phatr44657"/>
    <dbReference type="GeneID" id="7198133"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44657"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FUU2"/>
    <dbReference type="OrthoDB" id="10265925at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="69452" checksum="27DB073C67A7E702" modified="2009-02-10" version="1">MSSSYDNRGVTPPHAHRGDDEQKQNKRKLPPDHGSNYVPGAGDANQAPQSMDHFRRGRRERTEMRRREVYCPNENPRRQEEDSPRKNPRQEEHQSLRTDRPPSLKGIDLNRFMDDLCNQRLNVFKSLDSARQEYWELFHSGKVMTAVIAAAARRRQVRLAQQCWEWMDRVGMEKNVYHYNSMISVMEKDKNFREAMNLLKEMESRNIPKNEDLHFLSLGGGEIALGWWFEECMVPYMKNTEKLQDITAISIVTGYGKTRTRGRRHGDDGMKKRVLAMLRFMNIFELPQKNAGRICIDKDRLIEEVNRNGGKIIFDLASYVAWKEKETTANVIPDEPQKIRARFKPQAPRSGRPPFSRVESESTSMEYRLETMRHNGNDVNFSVALPLVVCRRGNDGKVERLDGHYERKISGEHHGIGCVEDNDARLSPKTDRFLEPKGYRRGDGSVPSVRFSESRKGNLVRKGASDHRPKGRYSDSRGEPREIGFSTLLSADVCRSVGTIDRGPRGSPEAARGGGYELENRSSYAHSGHPQRNDELNRPRGWNHDFSGDRRSPYSSSRHRHAGVPHQAIFHHNEPSNRDGGLVSSQRVTEERRPLNRGYCLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWD5</accession>
    <name>B7FWD5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179365.1">
        <property type="nucleotide sequence ID" value="XM_002179329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWD5"/>
    <dbReference type="STRING" id="556484.B7FWD5"/>
    <dbReference type="PaxDb" id="2850-Phatr45073"/>
    <dbReference type="GeneID" id="7200161"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45073"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285532_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWD5"/>
    <dbReference type="OrthoDB" id="44496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF23">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="249"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="673"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121666" checksum="AC4C12DBCF2591D4" modified="2009-02-10" version="1">MQSSLRARRGVAPRRKAAVGRYQLVLAITLSVALTGLVTTQFVLSTSLYSTQEKQQRQQHKSHAKGPNPSNLRTDSFPREQLHVVVPEEQKQSERRLNESSREHESRENDHEDEQKTRPDSEKKDDLLTQQDQKTTKRNEHGPAQEGIRKHKTDHEAPEKVESPVDEDHEVQKAHRETVQKFVDDRRVRLKHRISRPKVARAASPPEVEPQIEVAPPPEKRPYDILDDPLQNPDFNKPSKPLNFTAAVPYLGVLIDGGRHFFPMDWMKRAVDRLSDLRYNLIHLRLTDDQAFNVLLDSHPELAYPAAVNNPHQQVWTASELRDLTAYAKSKGVSIMPEVNVPGHAGAWAGIPHLVVHCPEFICQRGYGLPLNVTHHDLKPILTSILKEVVDIFDDPPFLHLGGDEVNMAGPCFNEVRSPVFNYTAFEVVLKEIIADVGYPEKQVVRWEMTGQANLERAGGVEQFWESYPGERHKAAGPFFISNRLYFDTNQDQNAYEVWQNTRRFYVNDYQPEAVPTAIIAGTFELSTTWWYDRNILGRLLAVALGARNETLPKTMKDQDHEKMVLDQYQVFCDQLGYSQAICETNGGPIIPTPEYKKKWGDGWVVWKAHICERMTTTEVTKAMRPRSSDRVATQANSYFWNVFGFPAHTHTRVGQHPTLPDDLQALQRHLIPHCGVMLDTTRSLVPADRLGTILTDTVAKLGFNIAQLRLVSNKGFTFAPSSLPHTVGHSLLATKEIKVYTRSDLMGTVAKASAVGIQMIPEISMTTGSAGWYESGYLANCPNRLCEIGDASIDVTNPFLPPTVYSLIYELRSIFSSSPYIHLGSDERQDAAACYQEANPTFHADVGAFERKMVKVLEASGIANDSVLRYANSQGEVYSDRTGGVTHYGPDHATEIPADAPIFVSVDLLRDDGWTLYQRVKELVSKKPLGILAEIRTLTAPRWEGLEIPERLLVYAMAVSELPTYANAAALGERYGELCRALSDRLPGLGRRHDCALPGVVSGKVTFLADTSTFVQQQCQMATYPVTQHHAKLVAPRYNATEWEQLRGAPRVFPAAGRDPQRHHPVVIGHGKSGDESPVESVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWN7</accession>
    <name>B7FWN7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_26780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179195.1">
        <property type="nucleotide sequence ID" value="XM_002179159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWN7"/>
    <dbReference type="STRING" id="556484.B7FWN7"/>
    <dbReference type="PaxDb" id="2850-Phatr26780"/>
    <dbReference type="GeneID" id="7200207"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26780"/>
    <dbReference type="eggNOG" id="KOG2492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_1_1"/>
    <dbReference type="InParanoid" id="B7FWN7"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="152"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="413"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="516" mass="58679" checksum="8EFD44A36A14ED18" modified="2009-02-10" version="1" fragment="single">MHPFKFHLRTFGCQMNVNDSDIVRALLLERGFTETLDETDADVLLTNTCAIREGAEQKVWHRLRELRGKFKSRKVVGVLGCMAERLQTDLFRDGLADLVVGPDAYRDLPRLMRDLLREPDDDDAELGRVNQAFNVQLSLDETYADVTPVRRHGNSVSAFVSIQRGCANRCSFCIVPFTRGQERSRPFASVVGEIQQLYEQGVKEVTLLGQNVNSYHDTSETALSVRPDSGYRMSNDGFRSRIRRHDGGYYFADLVAAVSDISSELRVRFTSPHPKDYPPPLLTLMAERPNVCNHLHMPAQSGSTSMLQRMKRGYSREAYLELMDTVHEIIPDVAISSDFIAGFCDESEEEHLDTLSLMERVRYDQAFMFAYSMRGKTHAHRTMQDNVPEDVKKRRLIEIIDTFQRHVQEKNESLEVGRLRLVLVEGESKRSHPGARAWQGRTDQNKRIIFPVDETVTVHDHAALAPVWTTLLRPHAKSERGFDPKVQLAELPRVSLSVGDYVVVQVTEAKGHTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWW6</accession>
    <name>B7FWW6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <source>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
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                <person name="Falciatore A."/>
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                <person name="Haruta M."/>
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                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
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                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
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                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
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                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
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                <person name="Shapiro H."/>
                <person name="Siaut M."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
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                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="7200149"/>
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    <dbReference type="HOGENOM" id="CLU_974748_0_0_1"/>
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    <dbReference type="PROSITE" id="PS51998">
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        </location>
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            <begin position="1"/>
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    </feature>
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            <end position="149"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC49316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    </evidence>
    <sequence length="274" mass="30579" checksum="9A2BAA5E48352F21" modified="2009-02-10" version="1">MLAQRSSSALALSASRQAARRNLSSQPKMHKVKDHWQNLKSKRPIDQDDLHLWLGFASASETIDTTLDRAKLRSKRQEPLLKQHDIWRRARIRRDVLNMDSAGLPVDEVEDAEIGTSNSMKETGSQKRASKRKPTNDSNQNDPSLTSSASEKRARKSTELFIPANPHDTDRSARIVDGRGQTLQSIPLCKGGGGGKNTTKAAISLTNKEEDDDLPERGTMPDTGQLRKWTKAYICCFNMEKVTIKHALEIAGDKFGVDLSSKKSELKDLLTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXH9</accession>
    <name>B7FXH9_PHATC</name>
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        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179561.1">
        <property type="nucleotide sequence ID" value="XM_002179525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXH9"/>
    <dbReference type="PaxDb" id="2850-Phatr45386"/>
    <dbReference type="GeneID" id="7200006"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45386"/>
    <dbReference type="HOGENOM" id="CLU_023767_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXH9"/>
    <dbReference type="OrthoDB" id="51274at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="226"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="454" mass="51486" checksum="F5F80E5D314C8D80" modified="2009-02-10" version="1">MTTRNDPRREVGSWVETKATAVTCEAECRRRYGALWNSKMVQGVISEVLVTPGFRTNRSTTNIKAQYYLGGGTFRVKTLNIRRVKLFAPSALNITNRNCEISNLDQASLSLLPREEAHSDYPKETQTPIPYTPIPPIPMDIHPGLAQVTGNNNGDENTGLDSEDQPTDRDVAPDADAHGTFWYNDSNATKCQMNGEVSFRPWGVKNTVGEIFGQGTDSRRSVSCLDYFLMMFPTTTLNTMSDETSKVLSSMGQKEISNGEMLKFFGVLILATRFEFSARASLWSTRSTSKYVPAPAFGRTGMSRERFDKVWQCLRWTKRADHLSAEMGNESVRWTMVDGFVQQFNAHRENRFRPSDLLCVDESISRWYGQGGHWINHGLPMYVAIDRKPENGCEIHNTACGRSSIMLRLRLVKTAAEEALNGERHRETLHGTMILKYLVQPWTMSDRIWLQQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXJ2</accession>
    <name>B7FXJ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_6847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179777.1">
        <property type="nucleotide sequence ID" value="XM_002179741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXJ2"/>
    <dbReference type="FunCoup" id="B7FXJ2">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr6847"/>
    <dbReference type="GeneID" id="7200492"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6847"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_1_1"/>
    <dbReference type="InParanoid" id="B7FXJ2"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000004">
        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="167" mass="19213" checksum="65A9EE41A7FC4BFE" modified="2009-02-10" version="1" fragment="single">SKTSKTPRRPFEKERLDAELKLVGEYGLRCKREIWRVQFALAKLRKAARTLLTLDPSDPKRIFEGAALLRRMNRYGLLADDELELDTVLQLTTQKLLERRLQTKVYKQGLAKSIHHARVLIRQRHIRVGSQLVNVPSFNVRTASEKHIDFSTNSPYGQGAPGRVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYC0</accession>
    <name>B7FYC0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179909.1">
        <property type="nucleotide sequence ID" value="XM_002179873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYC0"/>
    <dbReference type="STRING" id="556484.B7FYC0"/>
    <dbReference type="PaxDb" id="2850-Phatr45630"/>
    <dbReference type="GeneID" id="7200667"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45630"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045047_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYC0"/>
    <dbReference type="OMA" id="FAITWFN"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="355" mass="38897" checksum="D6895772AACB2FE7" modified="2009-02-10" version="1">MNLKSEVFLSVVAYSLCSGTLVLLNKLTLHHLPYPSLVVSFQLLAALIFIYGAKHTGRLQVDALEWQYVLPYLFYILLFSVGVFCNMKSLSMSNVETVIVFRALSPCIVAFLDVLFLGREYPSLQSWTGLSLIALGAYGYASFDAQFQTQGLAAYAWPGLYLFIISLEMAYGKRIIQSVNLKTLSGPVLYTNLLGLPPMLMFAAMGHEYRSFVYDHMVEQKPVGGVAVSLLLLGCAAGTGIGYAGWWCRGNVSATSFTLIGVINKCLTILLNVMIWDQHAPPKGILSLALCLVGGSIYRQSPLRNNTLKTSSSVAVDDGDDKNGRDDSDSVATDAEDINEQVELLEAEKGMKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYD1</accession>
    <name>B7FYD1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_20082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179716.1">
        <property type="nucleotide sequence ID" value="XM_002179680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYD1"/>
    <dbReference type="STRING" id="556484.B7FYD1"/>
    <dbReference type="PaxDb" id="2850-Phatr20082"/>
    <dbReference type="GeneID" id="7200403"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20082"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_2_0_1"/>
    <dbReference type="InParanoid" id="B7FYD1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="511"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="716" mass="78952" checksum="3B3D147ED82943E0" modified="2009-02-10" version="1">MGYARANQNGHGIHQRLRARAFVMSEPYARTVCFVSVDIGMGSDLLTQRVIARLEELLPIQDGFDKRLCHLDNLSISGTHTHSAPGGFLQYALYQITSLGFFEEVLEVYVEGVAQAIRRAYDNLQVGSIAVAQERLQGASINRSPSSYLLNPVEERDLYVEDGDTDKRMLQLNFLNANEKPIGALNWFAVHGTSMNSSNRLITGDNKGYASYLMEKHFNENGTLPGKGQFVAAFASTNLGDVSPNTAGPRCIDTGLPCDYYTSTCNGRTELCIAFGPGKNMIESMEIIGRKQYVLASALLGTSNVKKLKGRVASRHSFINMANLTVRMNNTTFARTCPAALGYSFAAGTTDGPGDFDFTQGTNTSNCIWDIIGGFLSTPSTEQIQCHAPKPILLNTGEASLPYAWDPNIVPISVFRIGSLFILNVPGELTTMAGRRLRKAVYEVVRSNGVADPIIAIAGLANSYTHYVTTFEEYSGQRYEAASTLYGPHTLNGYIQEFRRITLDLLINRASASTKAPTDLTRKQITVIPPVELDTIGLGRKFGSVAVDSKDQYIRGNDTVVVSFRSANPRNNPRIEGTFLSIDYLDNDGNWQMQYNDGDWCTRFIWKGGIVRLGSSFAEIHWKIPSDTMRGIYRVCHYGTRKSLLGSAESAIYYAPEWIISNLLGSITANMILQSVKLAIAVSDQIQRFTAGSLGHSRYKEFYGCTRAFLVHDHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYJ3</accession>
    <name>B7FYJ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_27263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179942.1">
        <property type="nucleotide sequence ID" value="XM_002179906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYJ3"/>
    <dbReference type="FunCoup" id="B7FYJ3">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYJ3"/>
    <dbReference type="PaxDb" id="2850-Phatr27263"/>
    <dbReference type="GeneID" id="7200468"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27263"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="InParanoid" id="B7FYJ3"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000035">
        <property type="entry name" value="Fcf1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="196" mass="22259" checksum="97382C38EA60C35F" modified="2009-02-10" version="1">MGRAKQTRKFAVTKKLLSPKDTRVRENAVQAQAQAAQKKAREAPRHVEQAVSALFFQYNTQLGPPYHVLVDTNFINFSIRKKLDMVRSMMDCLLAKAIPCITDCVMAELEKLGGKYKIALRLAKDPRFQRITCGCRGNYADDCLVQMVSSWRCFLVATCDKELRGRIRKIPGVPCMYVSGYRYTVERMPEAFGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYJ8</accession>
    <name>B7FYJ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179945.1">
        <property type="nucleotide sequence ID" value="XM_002179909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYJ8"/>
    <dbReference type="PaxDb" id="2850-Phatr45693"/>
    <dbReference type="GeneID" id="7200432"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45693"/>
    <dbReference type="HOGENOM" id="CLU_1484768_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYJ8"/>
    <dbReference type="OrthoDB" id="43916at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="207" mass="22979" checksum="DD436A74E8A323AC" modified="2009-02-10" version="1">MNSMSKAYGKRRQARLVLLTQTGLHMSFLFYSVSGVYGWAPSSFVIAKRDMSVVPLSIQTRCSAAAGSDSSSENQTSEAREMKDLILSLSKERTDDSRRQRMQCIFTEAFSRPNGDPQRFTHLFDQQLIILGDQVKAKAAAMAIDLEQEADTHAISTEQSLADNEAGKMREKSAEEKQLWALVDMMVQSKTIVKRASGDLGSKGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYR6</accession>
    <name>B7FYR6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_12544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180219.1">
        <property type="nucleotide sequence ID" value="XM_002180183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYR6"/>
    <dbReference type="STRING" id="556484.B7FYR6"/>
    <dbReference type="PaxDb" id="2850-Phatr12544"/>
    <dbReference type="GeneID" id="7200818"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12544"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYR6"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IPNS-like_sf"/>
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        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="258" mass="28189" checksum="EEE0604BC993FE02" modified="2009-02-10" version="1" fragment="single">LEKALGANGTGLIAIRNVPGFVEAKQAFLPRAHDLVQLPSSQLLALEDPVSLYNAGWSHGKERMGDTPDFAKGSYYYNPVTDCPGSAADRQAYPVSYPCNVWPAEASLPHFQTQANTMGAILKDTVVALARHIDQLAAQKVPDYPQDFLYTHMQATEKVKARLLYYFPLTNMSREDSWIGWHNDSGFFTALAGDLYVDHETGQVLDQSPDPAAGLYVIHRSGQTQKVNIPPDCVAVQMGECLQIVTGGAVTATPHCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYR8</accession>
    <name>B7FYR8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory proteasome non-atpase subunit 11</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="primary">RPN11</name>
        <name evidence="8" type="ORF">PHATRDRAFT_20227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180023.1">
        <property type="nucleotide sequence ID" value="XM_002179987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYR8"/>
    <dbReference type="FunCoup" id="B7FYR8">
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    </dbReference>
    <dbReference type="STRING" id="556484.B7FYR8"/>
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    <dbReference type="GeneID" id="7200819"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20227"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="InParanoid" id="B7FYR8"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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    <name>B7FZ58_PHATC</name>
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        <recommendedName>
            <fullName evidence="3">Beta-carotene isomerase D27-like C-terminal domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45919</name>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180091.1">
        <property type="nucleotide sequence ID" value="XM_002180055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ58"/>
    <dbReference type="STRING" id="556484.B7FZ58"/>
    <dbReference type="PaxDb" id="2850-Phatr45919"/>
    <dbReference type="GeneID" id="7201007"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45919"/>
    <dbReference type="eggNOG" id="ENOG502RKQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607614_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ58"/>
    <dbReference type="OMA" id="QLGPWFY"/>
    <dbReference type="OrthoDB" id="416096at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038938">
        <property type="entry name" value="D27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025114">
        <property type="entry name" value="D27-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33591">
        <property type="entry name" value="BETA-CAROTENE ISOMERASE D27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33591:SF2">
        <property type="entry name" value="BETA-CAROTENE ISOMERASE D27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13225">
        <property type="entry name" value="D27-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852833" description="Beta-carotene isomerase D27-like C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-carotene isomerase D27-like C-terminal" evidence="3">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="451" mass="49425" checksum="9071BFEB4D299930" modified="2009-02-10" version="1">MVGRNQRRSVLLVAIAIVPYTECLTSVSLAKQRNCVLSARFAENEGQQVTPPVQRSTIPEESIVSSTDDTATALSAGIVHEKSSSMLSDLNWESIGRVFLSEVKETADCVSLAAGPLFQSDALVQAEAIVKVCDELDTVKPVENMFVSEKLGLRRRALEFKRHELLVKLMRQNYDSYVATAAFLSPSRIPRKDLPNIQDVPYEKDAEPARIVIGEGGEDLVADCRIEDMKYNESPLDKLLLSIFRNLVTKNTGGVTSPKEGILGLVDQGRTFMLKPGQTPEAQHKMVSDTLAGLMTPVLPPFYGIFMSGIVPKIGTEFDGKQFGPWFYAPWLTSVVTPTFFGFLVGPSRPNHRKDGQLGGLVVEKCKFLQKSGCKGLCLHQCKLPAQQFFKDELGLPLTVSPNFVTQECQWSFGESPLPASEDPSFPTGCLVGCESRKTLVATGSRVDACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZB0</accession>
    <name>B7FZB0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synthase of glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GltD</name>
        <name evidence="11" type="ORF">PHATRDRAFT_20342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180120.1">
        <property type="nucleotide sequence ID" value="XM_002180084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZB0"/>
    <dbReference type="STRING" id="556484.B7FZB0"/>
    <dbReference type="PaxDb" id="2850-Phatr20342"/>
    <dbReference type="GeneID" id="7201030"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20342"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_1"/>
    <dbReference type="InParanoid" id="B7FZB0"/>
    <dbReference type="OMA" id="NRRIEQM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000124">
        <property type="entry name" value="Glutamate synthase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroprymidine dehydrogenase" evidence="10">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="218"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="458"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="580" mass="64707" checksum="B0E19A27985D8EBA" modified="2009-02-10" version="1">MLSSVSRRVLSHHQARRFKSTHVKGSSSAGHGPIGEDGRHEIWREGIYDHDNEPKIKRRDGSYSSIEKLRGFLNYERNPEPYRKPLERVMDWGELNPTEEDELHHTDLERKVQAARCMDCGTPFCQTHTGCPVNNLIPEWNNLVYNGQWEEAIDRLHKTNNFPEFTGRVCPAPCEGSCVAGLVDSPVTIKNIEYAIVDRAWKDGLITPRIPKERTGMTVAVIGSGPAGLAAADQLNQLGHKVTVYERADRVGGLLMYGIPNMKLEKETVDRRVNLLREEGIEFVTNADIGNNVDINELRSNHDALALCMGATKPRDLPVPGRELKGVHFAMEFLTANQKRLLMTKEGTLESKWEKDNFITAAGKDVIVIGGGDTGTDCIGTSMRHRCKSVTNFELMPQPPMDRATDNPWPQWPRVFGLDYGHAEVQAVFGKDPRVYSVMTKEFIGDDQGRVKALITQDVEISDKGPKAIEGSEREFPCDLVVLSMGFVSPEDYVVGELGLDTDQRNNIHATYGDFRTNVEGVFAGGDCRRGQSLVVWAINEGRGMAASCNEYLQAKRDTKFSPSHQTGVFHNLSSLSPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZI8</accession>
    <name>B7FZI8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180155.1">
        <property type="nucleotide sequence ID" value="XM_002180119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZI8"/>
    <dbReference type="PaxDb" id="2850-Phatr45714"/>
    <dbReference type="GeneID" id="7201074"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45714"/>
    <dbReference type="eggNOG" id="KOG4621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_875691_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZI8"/>
    <dbReference type="OMA" id="VQDIQKH"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36055" checksum="65C6E97B8A9CD633" modified="2009-02-10" version="1">MSWKNWWRPSICRQDPPSASSTSLDGETRTLRSFDCELPDPDADSQLEEKAENAAVRDFDVKRAELLGIRRRRMLHRTEPQSTSDTFPHVCQGESWDCGIACIEMVYLWCCQSCRVDAFPLSAVRDWMVRFASTQSIWTVDLVILLQGLKDKLQLPINLLFCSDTLRVNTALAALDYYQSTFDKDRKRVQHRLQAVSKMNIPVHQGELRVDDLVAILSDDNAVAIVLVNNAMLMDQDVPGQLGRESCYTGHYLVLSGVSSKPQHVTACHDAWRENSPSWCFIAHNPASDEKVTFLNPVTLELAWDSIGTDHDIIFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZT4</accession>
    <name>B7FZT4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180554.1">
        <property type="nucleotide sequence ID" value="XM_002180518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZT4"/>
    <dbReference type="PaxDb" id="2850-Phatr35895"/>
    <dbReference type="GeneID" id="7201518"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35895"/>
    <dbReference type="eggNOG" id="ENOG502QTBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080299_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZT4"/>
    <dbReference type="OrthoDB" id="9973624at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="30553" checksum="9C85FBC8722E1970" modified="2009-02-10" version="1">MFDPSAGCRALVVATRLHLGKASAPPLQKDLDAKVASFIRFCSHSCQAAVGVVAVDATERIAGFDLVKAVQRSCDKALEDTSVSTEIILLPVSPWGKFVPALNALVTFATTHACKAKQVLFVSAETMASPESIDVLLSHITAADDVLVAGALLPGHLYEASVDGNEALEVELNGRTAPWNTMAVWNLKKLALTGFQLVSEGHLTDDQTQPSYGVEEVVAIAMLQALLGKEMAVAKLVRLPGVDWDQSFCDPERQKWHVAKMESKRIRSQVQLDLLGLKGSVIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZX3</accession>
    <name>B7FZX3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180576.1">
        <property type="nucleotide sequence ID" value="XM_002180540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZX3"/>
    <dbReference type="PaxDb" id="2850-Phatr46062"/>
    <dbReference type="GeneID" id="7201417"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46062"/>
    <dbReference type="eggNOG" id="ENOG502S355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370279_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZX3"/>
    <dbReference type="OrthoDB" id="40547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="752" mass="85296" checksum="2C185E7DA8028B61" modified="2009-02-10" version="1">MSNDDASLREQHLDWSSKQGRILTANGTASSLYTSERGFSFRSDELPHHFLQLGTIHDVHPRLPNTQVLLPIVGAWKRTFFYGGWEYTCEADEITFNLQTHSLFIDLRVPRSRNELLRNRVTASVPPTSLDDLDATQLRYYARQHCFAGYTHGSFTDDAASRTGMDCCCTRHHCIDWNYVGTGRDRPNKWWVQLHENQSGNTWKEWAYATNDCAQHYYCEQWERLPQDDPPSNVPVVAFRKRRNQNSPERDGVLVIVGDHFNYCVDRQSMAGFEKYAACTSLVATVDAAIKADDLVSARAWLSLRGGHGRISEGWIVDNAIEFWTEGKALWEKEDLSTTGNALEDFCLVWNGEPWDLYESNVQNTHDLKVLLHTGLRKRTTLKSGSGAPKKPDLTVTVTNHERMNTRGRFCPTNFPSIPIIGLLHQAIRTGIESLRVLTSPSLLNYHFAMNHSRTIQAKFSALSVEADTFRREADKATQERLRVEQELQALHAKQKEITHQIRVGQDALGSFDREKAALLNEKKRLDAQLQQERTLLEQCCAESDALVSEEVQAKQEFVKELSQANKDLSDLLLGQEDRRLRSLLSVQTVPALLATIQEVSSPDSSDSSSGSELEAAIASLKEETEAYNRNLEHQKHLEEQIATFRQRFLSISASGKNQVMCRRRIHSRASKLVSPPSFYSSEPQSIAEEQLNELESVWSQNREDEEDSDPNSRLTNVADVSPVHLQLFYGTEKHEENMDVEGSGDVDAMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Q4</accession>
    <name>B7G0Q4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180714.1">
        <property type="nucleotide sequence ID" value="XM_002180678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Q4"/>
    <dbReference type="STRING" id="556484.B7G0Q4"/>
    <dbReference type="PaxDb" id="2850-Phatr50959"/>
    <dbReference type="GeneID" id="7201220"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50959"/>
    <dbReference type="eggNOG" id="ENOG502S5G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Q4"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="146" mass="15492" checksum="5396F8234A9CBFF5" modified="2009-02-10" version="1">MAFCNSESTIRKVLHNSKSIALIGASHKVERPSNEVMAFLLSSGYVVYPVNPGLAGQELYGRQVYASLREIADPIDLVDIFRASDAVGPIVDDAIAVGAKAVWMQIGVVNEEAAAKAQAAGLDVVMDRCPHVEMPRLGIDGPSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Z6</accession>
    <name>B7G0Z6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_36310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180948.1">
        <property type="nucleotide sequence ID" value="XM_002180912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Z6"/>
    <dbReference type="PaxDb" id="2850-Phatr36310"/>
    <dbReference type="GeneID" id="7201634"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36310"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009133_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Z6"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="211"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="536"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="882" mass="98123" checksum="604439946B23D53D" modified="2009-02-10" version="1">MNENFIIHPLRPEYHRLQSSGGTGSSAGGETEFDDSQVLRQTFMVYLPILVVVVLLFSLIRRKYRRAFNVRSWLDPIKTPLAYNQYGFFSWFWKLKSISDDKLMDECGMDALCFVRVLRMGFKISLLGVLCSAVLMPLYATADDSQNTRSITDNIAQLTISHVPEGSPRLLGAVIAAWIIFGYTMRLILKEFVWFIEKRHKFLATIRPRNYAVYVRNIPNELRSDAELENFFRQCFQSESILEGNVALKVPELSKLVAQREAAITKFEHAVAVEDRTGEKPQHAPSLASAIRGSLKGGGEKVDSINYFASEIKELNQVISKHIDDLNENKTCFSHDVEQPHASGSNRQISNGVRKTRSDSENERYGNMERTGLLSVSEGRSDHSVKEDCSTSPRNDIDTPNGDPGKIETAENAGYNAYRATNDATPGDSEGKTNPGIVLKNATKKCRESASSIGGAVKDSAKAVAENSTSLLKSAEDGKPESAGFLSFRSLRSTHAALQLIHHGTPFTMEVQEAPAPDDVFWFNVGRGHKELQVGRLMSFAATAVLCLFWTIPVSFVASLSTIESLRAEVGFVDDLLDTLPFLAPFFEIAAPLLLVVVNALLPMILRVFSMMEGPVSGAVVEASLFTKLAAFMIIQTFFVSAISGGLLQELSSLVQSPTSIVDLLSTSLPAQATYFIQIIFVTTVFSCGMEILRVVPLLKAMLRRFLGPRLTERERQQPFLTLRPLSNPLDFEHAGFSSNIVLYYIVFLVYSVISPLTSIVVAFCFAFMDSIFCHQFVYIYPNRSDSGGKLWLNFMRVLIACMFVAEFTIVGLLALKRAPIATPLMVPLIVVTALFSVYINEQHFKVTKNQHSSTFDSAFLKDAYLQPELQTKEARFGFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G129</accession>
    <name>B7G129_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_1859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180779.1">
        <property type="nucleotide sequence ID" value="XM_002180743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G129"/>
    <dbReference type="STRING" id="556484.B7G129"/>
    <dbReference type="PaxDb" id="2850-Phatr1859"/>
    <dbReference type="GeneID" id="7201650"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1859"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457496_0_0_1"/>
    <dbReference type="InParanoid" id="B7G129"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="33064" checksum="2EC92CB52F5C152E" modified="2009-02-10" version="1" fragment="single">LKSGSFATVCRGTHRATGRKVAIKCVLRKDLPPADDAAIYDEVAILASLNHPHIVPLIDFFDEKDCYFIVMELMSGGDLFDRIGTKKAYSEADARDLIVKMLKAVSYCHARKIAHCDMKPKNLLLMSDDNDSFIKLADFGFAARVHEPKCLSKQCGTPFFVSPEILMRKGYDQQSDMWSVGCIVYLLLSGNLPFMGRTQKELFRKIVSGKYEFVSDDWKDVSDDAKDLVQKLLVSNPDSRITANEAVRHKWLKASRDRLGLIMLQGTSQRLKTFNARMKLRSAMIAVDWISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1F0</accession>
    <name>B7G1F0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Choline dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_46493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180844.1">
        <property type="nucleotide sequence ID" value="XM_002180808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1F0"/>
    <dbReference type="STRING" id="556484.B7G1F0"/>
    <dbReference type="PaxDb" id="2850-Phatr46493"/>
    <dbReference type="GeneID" id="7201826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46493"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_0_1"/>
    <dbReference type="InParanoid" id="B7G1F0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="232"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="656"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="85986" checksum="B644C91C93CB265E" modified="2009-02-10" version="1">MGPNAAEDAEATALLPRRKGNEIGSYQYPTAPSSTLEEGHYSSPESNGSRSDGRDHAVHFSFTRRDISNKFVEESWCNRLGRSCLSWTLLLIFFILVFEGCLIYLSYRTMSPAAVPMLNLYDYIVVGGGPSGIIAATKLAQSFPTLQILLLESGTDSQSSVLKQQSILKEGATVSAAESGSTLWQEDAYQLNKFDVPLLWSGVASSRGRRDVLHLQAPSWSSSHHWPIDKTLMGRGLGGSGLHNAMIYVRSLPTDLEAWNVTGWTYDDILPHYVALEQYVEDHIPSQPFWTNDQGSTISKANWRGTTGPIRTIPAGSAVDALAPLFVQSAVISGERLAKRGFNHPSPAARLGAGYYEFNIRHGVRDSVAHALLGGHKAVPRNLIVRTGLTVTRVTTKPRRNEVPRVTGIEYFHSATGRMGKFLLRSDDVSEVILATGAIMTPQLLANTGIRPGGSVVHLPGVGRNLQDHPVVALKFKLVAEMEQDASSIYTLGDEMEDYVLSVAGLEDGQAKHKKLSNSSLSLQQALYSRLGTLGTAGFSAGAFLQSPFAKHDVPDLQVTVFPREIEPHVTRKQNANERAQMRCRSMLITVALLQPDARYQVEPLLSDLTSANEIFEQTAETERSMNASESSVPLTHYLGYNLPSIELPAGRSEYLSKRDVRVLAWGIERVRAIQKMPPLSQATGDELVPGAELVGEYLENHIRVESMPNSHWVGSTKMGPDSDTLAVVNERLAVRGVQGLRIVDAGVIPQVPNGNTHSTVCVVASRGAELIEQDRRKASQQSNNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1N3</accession>
    <name>B7G1N3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180886.1">
        <property type="nucleotide sequence ID" value="XM_002180850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1N3"/>
    <dbReference type="PaxDb" id="2850-Phatr36547"/>
    <dbReference type="GeneID" id="7201703"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36547"/>
    <dbReference type="HOGENOM" id="CLU_889848_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1N3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="313" mass="34696" checksum="C15B83DC0F6388BD" modified="2009-02-10" version="1">MSWFSSRRAKPAKESAFNTDDKPQNAFGGFGAVAHFDDGPLRDPRMANDFLERGTKNENIHTHSDTSSDGDDAGSEAESGSLSDDSFVGGPLMYESTCSDDSITVDTADPDSQDWNLRKANNFLQDFYDKEDLERVSQEQHRLRSTDDENDAESASSSDQSSEEGESDSETLEKSHSPLYKTCKDADICHEDQDLGTAKIDTATTLSSHDAKKFPIAPEIFDEGYGAEHDGYDVAPNESQIHECSETETSSQHVVVHDFSTASALRPAVAEARSTQRSCEAISMKNLRRARLMDASTGQMHEYWSRTKRHKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1P4</accession>
    <name>B7G1P4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181067.1">
        <property type="nucleotide sequence ID" value="XM_002181031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1P4"/>
    <dbReference type="PaxDb" id="2850-Phatr46571"/>
    <dbReference type="GeneID" id="7201851"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46571"/>
    <dbReference type="eggNOG" id="ENOG502SZQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G1P4"/>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="30424" checksum="9727B74BDA4B7D74" modified="2009-02-10" version="1">MGCCCSCLEKQGSPEKETEMKPCSSRDSSSEKSLSISRVMSAPSIEIKDRTTVSGYGLALLGVAVEQDAAYWEGHVDLPEGKGPQEIMLGVATKKDRKFYTALEQQEEELPDSTGTDLMRKITVSNEDTRGGYPKSFFTSSIPADAATIPPTLLAKIYEAALVVCPCANHVAISTEKVENVVKDPQKPTPSISFVRGVRPKTEGVEPGWEGPETSGAPVTPPRRKLPPTLIAAVCQPWYLPRRLGSTAIHSLAKRPAWCRDMAPKNAPAPIARASFGIVPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G226</accession>
    <name>B7G226_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_37077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002181137.1">
        <property type="nucleotide sequence ID" value="XM_002181101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G226"/>
    <dbReference type="STRING" id="556484.B7G226"/>
    <dbReference type="PaxDb" id="2850-Phatr37077"/>
    <dbReference type="GeneID" id="7202229"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37077"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_1_0_1"/>
    <dbReference type="InParanoid" id="B7G226"/>
    <dbReference type="OMA" id="GWSVATI"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="24872" checksum="457D46680A5A17E3" modified="2009-02-10" version="1">MATDICTRRLTKELRALQKDPIRDPKITVAPNESNLLEMHYVIEGSKDTEYEGGVYHGKLIFPREYPLKPPGVMMITPSGRFQPGRRLCLSMSDFHPESWNPMWSVSTILTGLYSFMIETKPTLGSIETTARKKRQMAAASLEYNVKHNPHFVKLFPEYVNRYEQERASLSSQPTSESSATSSYSVSTAIRPVDGLVLPQGVIATIAGVVALLSILMAVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2R2</accession>
    <name>B7G2R2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181425.1">
        <property type="nucleotide sequence ID" value="XM_002181389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2R2"/>
    <dbReference type="PaxDb" id="2850-Phatr47171"/>
    <dbReference type="GeneID" id="7202064"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47171"/>
    <dbReference type="HOGENOM" id="CLU_1921193_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2R2"/>
    <dbReference type="OrthoDB" id="44591at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="132" mass="14816" checksum="3A7C1FBA7EFC70EC" modified="2009-02-10" version="1">MYGRGERHLTAVLDENDVVVYQTGTWLVDGVSVGEGRAGFAYAQVETIQLVWTHNCEHGVVRGLALELVHDKDNADSPPIFVRHQFDQIEFGPEQLLAKIPVEWVNDSQGETKASCRALVSVNDQHWQDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2U4</accession>
    <name>B7G2U4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_51040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181264.1">
        <property type="nucleotide sequence ID" value="XM_002181228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2U4"/>
    <dbReference type="STRING" id="556484.B7G2U4"/>
    <dbReference type="PaxDb" id="2850-Phatr51040"/>
    <dbReference type="GeneID" id="7201972"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51040"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224836_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2U4"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="220"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC47187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="607" mass="67830" checksum="389FBF51C77C12DB" modified="2009-02-10" version="1">MYRLIHLWFSCEDEGSSNGSLVEIMAEAVTRLPSFRFVPATSQLLSRVEKRNTGSFQETLHTLILRMCHDHPYNCLVQVVSLANGKTIGSGVSGRQAEVFLENTSDTKVDGANEILASLRTSERKPLGRLMEGYISLTDAYVHLAMYPTHDFQKAKNKKFPFSAVSKSHAERLDQCLGVGRRKVPHPPCVLTKPPPIRPASDYTDETGQLIGSESVVGFEQAFSITESGLHRPKIVYCLGSKGGRFKQLVKGEDEIRQDAVMEQVFGYVNELLSNGDLSDSLDEIRRTTGAGHLRLVTYNIVPLSPASGVLEWVDHTIPFGEFMMDKKGHVGAHSRYYPGQWSSLVCREQLRKAPKKEKLQAFNAICLNHSPVFRYFFVERFGHTPELWHEARMRYTRSVAVNSIVGHILGIGDRHCSNILIHEGTGEVVHIDFGIVFEQGKLLNTPELVPFRLTQNTVDGFGPVGLDGTFTKSAQRTLSVLRKNSNALLTILSAIVSDPLYKWSVSPVKARLRQEQQQHQDEEEQGENKRTSMTTTTSSTKVSRSQGQENEAASHAIRRIQEKLQGYEDGTSGEQQSVEGQVQLLINSAKNKDNLCLMFCGWAPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G353</accession>
    <name>B7G353_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181557.1">
        <property type="nucleotide sequence ID" value="XM_002181521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G353"/>
    <dbReference type="PaxDb" id="2850-Phatr37569"/>
    <dbReference type="GeneID" id="7202523"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37569"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089140_0_0_1"/>
    <dbReference type="InParanoid" id="B7G353"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33597" checksum="F9CD5C841CD1AC47" modified="2009-02-10" version="1">MATSHVIPPEFLPRENPKNIDENTDNETCIGSLFADDKDQDEQDDHPERLIQVVTVGHDQTYTLSLPPDVGTLFAHCVWSGSLYLSDFLARCAKDFLLHQKTVELGAGTGLPSLVALAHGSDLSILTDYPDELVLQSLRETVGLNWDAICDRRTPYFPRPPPVAVVGHDWGTSVDPVVREAMRLSHGVDKSNFDLAILSECLWMHRSHAALARSVDQLVHPKHGRVVLTYAHHVPGYEEEDDAFFELCSTHHRLVTVHQEFRLCPYMWDDTKTITVYLRVLARPSGAQVVTGRWHFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G392</accession>
    <name>B7G392_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181577.1">
        <property type="nucleotide sequence ID" value="XM_002181541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G392"/>
    <dbReference type="PaxDb" id="2850-Phatr47400"/>
    <dbReference type="GeneID" id="7202442"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47400"/>
    <dbReference type="HOGENOM" id="CLU_450171_0_0_1"/>
    <dbReference type="InParanoid" id="B7G392"/>
    <dbReference type="OrthoDB" id="45845at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="607" mass="68009" checksum="0EB0D65C9065E0FE" modified="2009-02-10" version="1">MPPYAAKDMGDKNNDNLPSAGFLDESRFSTGEPPLRMPGYANSLLSQSPSPNTPVENLVRHGNLETNRIIAALATKRRAEEDWTGRSPKRHQYQRCFDSSESKTSLAIILKDRTIDALARQQFQEALRFMSSSGTVASRQRQFDPSAFACLESQRDYNAFLSSQLGIVQGLEAYNLPTQAQLLSQPLQHRDLTDVSLAQAHYLPLPNLQASLSSRHLNLPLLFQPRFLPGSSLHHFQRPMQASLATRLHNIEGELGLQAQSFGVSSLTPRLGQTVPIRGFPTEKLASQSRLSLPPCDEGQVLPYTSRGNFALGIDEDSNWLSEFHCFVRSELIEVFRAGREDCNSRNNSISYQQVGIRCRFCAHMSSSARAGRSSAFPSSLRQIYQSFTMMLRDHFGNCEAMPAAIHRRFLSSKEMPSQGATDSKRFWVYSAMKIGMADSSDGIIINERTVAVGSSASSFGTNPNEPWADDALASIALVLPRDRSLVSEFLVVLMSQVQLVRLTESERIGNRRSLHIGLTGFGCRCCCEHRRLGLCRVFPARRRTLPSKVNDLYDHIRRCTVTPQQVKDRLMGLKYQRDADSSPGRDEEKEFYDRIWTRLGHSSNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3J9</accession>
    <name>B7G3J9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_8111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181629.1">
        <property type="nucleotide sequence ID" value="XM_002181593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J9"/>
    <dbReference type="FunCoup" id="B7G3J9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3J9"/>
    <dbReference type="PaxDb" id="2850-Phatr8111"/>
    <dbReference type="GeneID" id="7202276"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8111"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_954613_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3J9"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="99" mass="11541" checksum="69CFB113F2D2356C" modified="2009-02-10" version="1" fragment="single">MVYLDGPQVYACAQCRTHLTSHDDIISKSFHGRHGRAYLFDQCVNVRNGPSQERWLMTGMHQVCDIFCKRCDSMVGWTYLKAFEASQKYKEGKYIIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3V3</accession>
    <name>B7G3V3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181502.1">
        <property type="nucleotide sequence ID" value="XM_002181466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3V3"/>
    <dbReference type="PaxDb" id="2850-Phatr37456"/>
    <dbReference type="GeneID" id="7202323"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37456"/>
    <dbReference type="HOGENOM" id="CLU_817523_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3V3"/>
    <dbReference type="OrthoDB" id="46870at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855375" evidence="2">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="340" mass="36216" checksum="7204CC9558D74345" modified="2009-02-10" version="1">MLNLRCARPLAILSLVTLRQLAFARSWLDVADVALFAVSPMDPNRLLYSGESDPFLFPTPNPTTSPFSGPIATPTSRPVANVVAAPSTSEQRSNAPSARWENRDGNGGCQPGRVLHEVVLQDFGGDEQYNNSIAFWTMPDILPDERSETSSTAHISGPNPTSDGLDSASEGGIELFKGSWKAGEDSFSYICLQPAKCYQMEVEGGLGSSDATWEVRKVEMDINENMGAVVAKGFVPEKCEFSILNEETDALACPLRCNVSPETPAASFSSAPASALPTALLSDATEKPNLLRSTAPSDGPSLIPSDVPSYVPSYAPSIVPSEIPSSNVQSGFGTDQRIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3X0</accession>
    <name>B7G3X0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181512.1">
        <property type="nucleotide sequence ID" value="XM_002181476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3X0"/>
    <dbReference type="PaxDb" id="2850-Phatr47298"/>
    <dbReference type="GeneID" id="7202330"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47298"/>
    <dbReference type="HOGENOM" id="CLU_563202_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3X0"/>
    <dbReference type="OrthoDB" id="10677228at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="485" mass="55025" checksum="BCA0ADB2571044B1" modified="2009-02-10" version="1">MILLPRPQLCGIVGKSSFWCVLFSLILAMAGSPPVIEATGLRHGPWFSSSIFYDAAEGGIIGIDFPVTIHAPQMQKFGAILVILMLCALAYRILLQYLNAMAWPAAVQRMKVQGTSGAKADPFTVTPGWTFLSQSPAYWGIENTFHCLVHLPVYVWRYIALICYYLPRDAQRRYFRGETVSDKVLWDFITDTVLMLLCDIDSSGEILTYRCEGCSKGIFTNGTRDDCMIDGTTLVLKMKNGIVLSAKTKDGPVLDGKWITRNEILADALARTEALWGHTLIHYSGERSAASIARLEVDILKPCALHTHSIHDALLHSPVGPLTKTWTPFTSWLNRMEDVANGLEGMMPHQLHRIKDPRKFKVFNYMLRAHGVVSKILLKYNLAQEINVDDFFALVIMHDLDHITGYRAFWNEVPLRPSNETSFFMFFVSMYQNCVQQQLWTPPIINPFWSMYIKDSTQPFFQELYRGLEKIDKDLAGLARFSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G463</accession>
    <name>B7G463_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182017.1">
        <property type="nucleotide sequence ID" value="XM_002181981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G463"/>
    <dbReference type="PaxDb" id="2850-Phatr47586"/>
    <dbReference type="GeneID" id="7202804"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47586"/>
    <dbReference type="HOGENOM" id="CLU_378789_0_0_1"/>
    <dbReference type="InParanoid" id="B7G463"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855397" evidence="2">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="36223" checksum="B93C94D5831C04AB" modified="2009-02-10" version="1">MVSTTSKVVAAVLVMGGLLATQLDLTKDASVATPHANAPSKTTARGLKGARRLASGATDGYGSIDAVSTTGVSGSAGAGVTKQEALVNNKGSFVVTGSAGSPGGSTGGSAGVAIDQAGVESKGNAANYGVVDPAIVAVTSGGTGYFVGSFDTEAVATESPDVTEAPTVTPPVTISPTSGKAGKSSKPSPSGKAGKSSKPSPSGKADKSSSPKSSKSGTHSPSGTPSPKSSMPPVDDSHDSPDDAEMNFEVPSKLLVDLAEEEPTPASESGTSYAAAGGSFASVISGGTNTGVAPANAVAPGYATGSGGVESVTVEAGGAADSTANDSTVSAAADGGAEQDGSFYAYIGASASPGATVAPVGDAVISAGIEGVFGTVGEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4H9</accession>
    <name>B7G4H9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
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                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181918.1">
        <property type="nucleotide sequence ID" value="XM_002181882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4H9"/>
    <dbReference type="STRING" id="556484.B7G4H9"/>
    <dbReference type="PaxDb" id="2850-Phatr47675"/>
    <dbReference type="GeneID" id="7202871"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47675"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539146_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4H9"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="491" mass="54438" checksum="DC51007CB27C5830" modified="2009-02-10" version="1">MFKREASKRAERLIELLRKESNLNWIARRTFAVYAVGSGWTGAFGNGRFDQEISGHNDEEEAGSPLKIYDGSVKDISLGWGHTAILTEDRRLLLAGRPHDFSVLLRLRRLPLWVRNYAINSSINEFRGLDSRSVHPIALIGRLITWLAIRFKYPTTELEAARRHSIFPELAEIALPDSEVPSSVSCSAALTAIVTESGKVYAFGLNGFGQCGIGMTSNHVWNPSSPLRGLTSEFANQPRGEMEQSYPVVDVALGLQHGICLNEVGEVFCWGKGERGQLGQGLITTEAHTALPVKRAFTLGEKMKPQYQTIGQVTQIDAGMIHCAALTKDNEVLIWGKHVLPLLPGDENKKVSSDARLPYILPGLPKGVRVERIACGSHHTAILLDDGSVYAAGIATHTKEPIHEAVQILPPGVVNRPVRQFDAHMDRTTIVGADGRQVLQLHLWKDEELREFAAFTPAWVDHILDENPFAKISMIHRSWIHSVVVTEEQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4V1</accession>
    <name>B7G4V1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182138.1">
        <property type="nucleotide sequence ID" value="XM_002182102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4V1"/>
    <dbReference type="PaxDb" id="2850-Phatr47774"/>
    <dbReference type="GeneID" id="7202933"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47774"/>
    <dbReference type="HOGENOM" id="CLU_664752_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4V1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855414" evidence="2">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="414" mass="46004" checksum="AD029452CF1EB98B" modified="2009-02-10" version="1">MKLFFSVATTALLAGGARAVNLRAATAREAAVEGTQSSFASQAASQLAKKNKRKKGKKYSPSSDSDDPIMHGHLQIGHVLDVSSTDAKADMDLIESAFVNAYNNANPNGKYEVTSMTLEREVVIPEDLEATLAIIKGENVGQLRPGVFIDWYYFFGFHCRLCRDDDDYAALSATELPVLEASAHRVFEDQFCLTLHQSGLEEYSALADCSILFDYDGDGNDIDSGDQLELQKKNKRKNKKKGKKKHANNDEVMDGRLLIGHVLDLSDVDSQAEIELIQTAFVDSYNGANPEGKYELTSMILDRERIIPEDLEGAIATIKGENVGQLRPGVYIDWYYFFGFHCRLCRDDDDYAALSATELPTLSVSAHRIFEEKFCISLKDSGLTEYSEISECSIIFGGDSTYENIIEEKKQMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5P2</accession>
    <name>B7G5P2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Bifunctional aspartokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PHATRDRAFT_22113</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:23777"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182284.1">
        <property type="nucleotide sequence ID" value="XM_002182248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5P2"/>
    <dbReference type="STRING" id="556484.B7G5P2"/>
    <dbReference type="PaxDb" id="2850-Phatr22113"/>
    <dbReference type="GeneID" id="7203242"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22113"/>
    <dbReference type="eggNOG" id="ENOG502QQBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5P2"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04921">
        <property type="entry name" value="ACT_AKi-HSDH-ThrA-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049638">
        <property type="entry name" value="AK-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
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    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
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    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
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    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
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        <property type="entry name" value="HDH_cat"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000727">
        <property type="entry name" value="ThrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="25">
        <location>
            <begin position="448"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044938"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EEC46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="870" mass="94485" checksum="70A394A15A4E4902" modified="2009-02-10" version="1" fragment="single">MTPAPTMAATTTPGEGDSDAVHTGFAELPWQVHKFGGTSVATAECFLAVARVLEHELEIDPVHSCIAIVVSAVGGKPKVTDLLLDTVKAAAQRDAQGVDSLLEVVLQKHHDCLAALFVKEPSERDRLMEIIQGDIIDIRDILKTVALMKWQAARISELVSGYGELWSAQILTALMRLQYVYLDARRVITVDEEAIHNGAVVWELSQEKLDRVYREELQKLPQAAILHFVITGYVASNTEGVATTLQRDGSDYSAAIMGRLLQAHKITIWTDVDGVLSADPRRVPLAQILPEVSYTEAMELAYFGAKVIHPKTMQPAISSSPQIPIFIRNTFNPSFRGTRIYAPGLNKDKDKVVTGFSSVEDMALLNVEGSGLVGVLGVDRRLFATLERIGVNVVLISQGSSEHSVTFATKESQANSAKLAIEEEFRRELLQHRISKIEIQAPCSILAAVGDNMALTTGVAGRFFSALGDAKINILAIAQGSSERNISAVVLTSESSRALRAVHAAFRLSHSTVRVAIVGMNELGISLLKLLESQRSSLRSTFDIDLQVCTIFGGSNSLLLGAPATNASQTSFRDDETTFLEDGGRDVLLNRLIRNECPSHVIFDCTNDEELGQSHAAWLRAGVNVVTANNTGISGPAAQREEIAEAERAQGKNGAKYLREVTVGGGLPVINTLRSLLHSGDKIRRIDGILSVSLSFIMFRISPATDIAKCTVKEAIALGLMEEDPTKDLNNEYTSRVLMVLAKELNMDKGVEVSDIRDSSDKLLELICGETVDYTKFSPAVDELVQARVDAAKSRGCVLRHIASVDVKAKELSIKVVEVPEHHVLAVTPPSCECVRFFTHRHQRYPLIVQGPSAGADSTASALLAELLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G638</accession>
    <name>B7G638_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_48135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182656.1">
        <property type="nucleotide sequence ID" value="XM_002182620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G638"/>
    <dbReference type="STRING" id="556484.B7G638"/>
    <dbReference type="PaxDb" id="2850-Phatr48135"/>
    <dbReference type="GeneID" id="7203483"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48135"/>
    <dbReference type="HOGENOM" id="CLU_338743_0_0_1"/>
    <dbReference type="InParanoid" id="B7G638"/>
    <dbReference type="OrthoDB" id="49540at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15568">
        <property type="entry name" value="PHD5_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="840" mass="92094" checksum="F0D3725BF4B41D00" modified="2009-02-10" version="1">MEKSRTNQCVELPSSERSPETNGTHLTMSATQRYPTANKRRRMSNTMKDDARTQSKDGVLSGNDSSVASNFSGNHKNTGTDHYDDVDVLQNQGVGEMSKSMDWKHEIDPCNGKASDFTSSSVVINPSGTGGKQPNALFADRQSFTSSKNDFAAKNGKHSPSLSITTQIPNDIDTCVLSVSEIRHDAPKDWYHNEAMYTEKVCPGSELRHGNLNSPDEANIGNESQMLHSPAPRPYQERLRTPGSGGMGASPQRISHKYNKRSYPSQNHFGDDDLHSPCENPGSRIGPNFQVTELPIPSNNFKKSEQGVVIWSPQLARLATLSGQDLDGFLEKAKESNVSFQLMEALHRSGYNTKAALTEFIGMYHENPDMSIEITNGDQRRELESIFERLAANAHGDGNGMDSTARALKTRREKVIVHYYRWKCKSSVYQKRKSLLRRQPLEYDTCFVCQDGGLLLICDRCNKTYHPRCVNLRVVPEKEWLCENCKSEHIPRKKGRPTPTSGKEMLPTLLSVHKELGTAHNTKGIVTSSQTSFPLNGVADVSHLCPPPATIHIDSRSESTACFVSAFEGCVGCESERSVELEDDQGTVESPSNSGSSISEKSPSSASCPDVYGSNQSVTINSPGATLLRELLSDRSTLSSTSSDTSFMKSDTDFDDALEELSSECDSIPMTLRSPSQPDGGLPGFRAPANGTNQDSTADKSNSEALTSLQFASTCGQGISSTSSQNGAPYDTFGYIPPFRPPNYWTPAYVQQGLSSKVQYQPAATFAINPSPLPPSYCSNIAQTSHTTDSLRAFPPHLNPFQPGYAYFNQYQTAKPSVPIPNAMKYMQYLSAHNSSDPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G685</accession>
    <name>B7G685_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_54869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182681.1">
        <property type="nucleotide sequence ID" value="XM_002182645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G685"/>
    <dbReference type="STRING" id="556484.B7G685"/>
    <dbReference type="PaxDb" id="2850-Phatr54869"/>
    <dbReference type="GeneID" id="7203505"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54869"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616061_0_0_1"/>
    <dbReference type="InParanoid" id="B7G685"/>
    <dbReference type="OMA" id="TCIAAKQ"/>
    <dbReference type="OrthoDB" id="48546at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045203">
        <property type="entry name" value="RanGAP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761:SF2">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="445" mass="48237" checksum="D52E1AEFEBC8F7E8" modified="2009-02-10" version="1">MTVHVTLHTSGPRNVVQVADAESILQNFQATLARYTTDDGSALVDKLDLSGRAWPLSSLQVLEAFFEAHVVDTVRVLKIDDIIASLPTVDGLASLRWFARVFQHAPVAVLNLNDNALGTRGMAEIRPLLSNPHIRHLALDNVGISEAVVATLATILSHSSGDDPDTPGPLQLQSLSLGRNQIGIEGARSVGELLALCPHLESFSYASSRPQLAGTLALVQGLEKSEVTSLRYLNFEDCVFRGGDGEDPTQVLKTVLCRSPKLHTLLLPDCELGPAGLLLVILGIRYAKPPLTVLDLSANNAGPGGTYALGELLEYTDAPQTLQSLAFDNNEVETADVLNCVLRPVIRSPRVALRELRLEGNELEGLALQLLIDNPIPSLRALHLEENMDIGRQRAQRLQALYQTMGCVVYVDENLEIDENDDHDEEQKDDDAVDALVDSVKGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G686</accession>
    <name>B7G686_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182531.1">
        <property type="nucleotide sequence ID" value="XM_002182495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G686"/>
    <dbReference type="PaxDb" id="2850-Phatr48175"/>
    <dbReference type="GeneID" id="7203312"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48175"/>
    <dbReference type="eggNOG" id="KOG0632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452350_0_0_1"/>
    <dbReference type="InParanoid" id="B7G686"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="6">
        <location>
            <begin position="292"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="604" mass="67084" checksum="DC418D0A4A319FAB" modified="2009-02-10" version="1">MHETERDARVSRVIERVRLREEVCARPVAYGTVRYRIDRSLHTWVCDRYQATVLPIRSPRHRTDRDGVGTYRHTNSEGRGAGSATQCTRAQRALGFLPRRAVALALSGREKSFSRSTNTKHIFNTVSFGSFTRLSDFHHPLGSYGAVRLYGLTSIPANPIQTVTRTLSIPPGFPDHEIVPAPFTHRLWFRLVSLAHTSPSSTRTVPLGVERNSSRRPRRGSVALRRPRSLSFTTMSAYTRTDTHASAGSVGPSSPHCQTCTCHFHELDEAPHLVPSQQLPQSVVPLPPPLPEPTYSVRRRVLPASLVPLNSRQGTLWLTDCLTQNTAALYIPLSEHFCNQSDPAYCGVTTLLMVLNVFAMDPHVRWKHGWRYFGNEDVLLSQCCLTPERIRRAGISMHEFAQLASCQGVRVRMQRPQPPSAIETDSGSVHTNPSFDLDDLQRFRLDIQRVLSGTAETSGNPAAAMETNGVIVVSFSRAVLGQTGDGHFSPLAAYHAATDQVLVLDVARFKYPPYWVTVTDLYRSLLPHDPATSQSRGWYVLQPPLRSASYRGSAGGEDRRPAKLVPLVGEPHGARTHACPVQVIKTAYCQVAEHEPRNNDAKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6G3</accession>
    <name>B7G6G3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182568.1">
        <property type="nucleotide sequence ID" value="XM_002182532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6G3"/>
    <dbReference type="PaxDb" id="2850-Phatr38650"/>
    <dbReference type="GeneID" id="7203352"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38650"/>
    <dbReference type="HOGENOM" id="CLU_864542_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6G3"/>
    <dbReference type="OrthoDB" id="10668332at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="322" mass="35809" checksum="E454F98E69DB9D76" modified="2009-02-10" version="1">MSNTKPSNCCELSVWSSMIAAKRSDETESERLAKEYRQIACLLAASATQRERIDSIHPVKDTGVASLPILSQVVAQHLLRNDHPGFVPLLMLQQDGLQGNDDSHTSPDGQNEMNPAEHQDTSRHLVADRSSHLSTDVYLPCCHNCGGALQPGLLRTTVRLVTHKTLTRAQRRRLKRAQALAKQAPTRQHQYHTNTRPSVLADFIQRDSSQVPWDVRNYLSIKCGGCHSLSYAVGVPRRRKRAAPKDTPKRAFLVSANYDKKSAPKKRQETGDDFIALGSPSLTSNPIGDPRMGGNRQRLDRAGGKKKKPTRLMNFLSSLNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Z1</accession>
    <name>B7G6Z1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182943.1">
        <property type="nucleotide sequence ID" value="XM_002182907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Z1"/>
    <dbReference type="PaxDb" id="2850-Phatr48391"/>
    <dbReference type="GeneID" id="7203586"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48391"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017405_1_0_1"/>
    <dbReference type="InParanoid" id="B7G6Z1"/>
    <dbReference type="OMA" id="PASWWHE"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF100">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="149"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="425" mass="47396" checksum="91161C8B8F6A4833" modified="2009-02-10" version="1">MSDAKRQRLASPPSTPIDEGNQTGYHTRQKEQGGYQGYRFAEKVEGAPDPILDVLSPAMDPQSFFENYVSKRRPCVLSGLPSDWKHAVTVEKMLERAGDGKVQVERRSDKHSPFGQNRNDDRQVDMTFREFVGKLRGEEKDLFYLSTQSTETSQNTSLFLTPCLQLLESGDLPGKLKIAGNLVLQSCNVWMGAAVGSSGLHHDFHDNFYVLLSGRKSFLLYPPSEAAHIPTYGTIDKVHPNGLISYQSRPTRADGVPDSITQAKMSDEVESENESADSSDDEDEAVLGRGFDYASDTENDDASAFLHGDHDEYETLIREEGESQGYKTVLRDEARPDHFAKPVGASCGEPNANPGIGCQIDLQAGQCLYLPASWFHSVTSYTEDFEGGNSIGPHIAFNYWFHPPDRNCFLAPYTDDHWRHEDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G789</accession>
    <name>B7G789_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182865.1">
        <property type="nucleotide sequence ID" value="XM_002182829.1"/>
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    <dbReference type="AlphaFoldDB" id="B7G789"/>
    <dbReference type="STRING" id="556484.B7G789"/>
    <dbReference type="PaxDb" id="2850-Phatr48468"/>
    <dbReference type="GeneID" id="7203697"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48468"/>
    <dbReference type="eggNOG" id="KOG2860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636906_0_0_1"/>
    <dbReference type="InParanoid" id="B7G789"/>
    <dbReference type="OMA" id="RDEYMAN"/>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
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    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="TraB_PrgY_gumN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853057" evidence="1">
        <location>
            <begin position="22"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="431" mass="46190" checksum="C6848E9190E149E0" modified="2009-02-10" version="1">MMPSAFFVLGTISLLLSESQAWTTRPAQTSIRLFSRLHLSRPSSESCSKQTNVDNERRSKRFDSFSRRELFAATAGAAASIALGPSTAAFAPAPSIVTTAATCDTTVSVWQRGDRIVYILGTAHISEISSDLAGQLVKDVHPSAVFVELDLKRVSGVTVSPGTPVTSRLPISTDVTELPATGEGASTKQSKIIVSVPALPDSVASRPTESTGIASLAATTKQDDELASASPVLTESPRRGLGQRMLGFGAAAVGKAIQGMYKNLNDSGFKPGEEFVVAVREGQRIGADIVLGDQDVEVTLRRMTQALAQTDLNKLLDPDSELERGMRELMGDSDPSLASSPDAFKSELSTYVENMKTRDSVRKIMAQLQKVAPALVQVMLTERDAYMAAGLDTLNQFEVITAVMGIAHMDGVERNLQSQGWKQMRPSCPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8F4</accession>
    <name>B7G8F4_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183458.1">
        <property type="nucleotide sequence ID" value="XM_002183422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8F4"/>
    <dbReference type="PaxDb" id="2850-Phatr39360"/>
    <dbReference type="GeneID" id="7195068"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39360"/>
    <dbReference type="HOGENOM" id="CLU_563205_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8F4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="485" mass="53239" checksum="02B0E1E32A799D8A" modified="2009-02-10" version="1">MNHPRLEEIGSGKSLLDVSGIPISTACSSTPSASLSDEERKASFRDRFGPDPEPTTEKRACRPFSVMRGRSGRFEKQARVASTAEELAMCLPDSPPTLGGSPKLKKSSMWSTLFSSSARLEESSAHRPTSSAWITAMLPHRKGAKSSPSGSNILARSSTAFSKNEDDVRSTDRESLVFKNQPLHRKVMKRETYTVEEDTQTRHPKASFSRQNGSSVAKSPHSIAPSIVEQDAFDQSRSYLGSPLWTPDSPNSEKHDRWTPPHKNTGLLRKEFGIESSQELTWLKHPLRDLLGKSKQSNETEPRHAMGKKPSHDNFQVQDGDGGAFGLQGSSVLLGNRLSQMRAAGDPISLKVTLSLDKDLKDEDLNNVGKLLSQLEQYLSIAPRQGHFLNQHFSTKKIFNEAGSIDRESTGKHDAMRQKLFELEAEIDRTALESAAAAMLLEGCQDEKLSDHNLMVASSPVAASEKDSSSLSSDADELVAQPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8H0</accession>
    <name>B7G8H0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002183307.1"/>
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    <dbReference type="STRING" id="556484.B7G8H0"/>
    <dbReference type="PaxDb" id="2850-Phatr15297"/>
    <dbReference type="GeneID" id="7195120"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15297"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="InParanoid" id="B7G8H0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="146" mass="15384" checksum="8954F32CDD1068F1" modified="2009-02-10" version="1" fragment="single">RVAIVTGSNTGIGYETARALVLDHGMEVILACRSRDKAQAAADRIQQAFRTSASTPSQRVGRAVVIHPLDLASPQSVLDFCAALKDKYTAVHVLVNNAGRNTSGKSPSGGNLDLLFASNFIGHFLLTSQIMPLLQAGVGARIVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8S0</accession>
    <name>B7G8S0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183518.1">
        <property type="nucleotide sequence ID" value="XM_002183482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8S0"/>
    <dbReference type="PaxDb" id="2850-Phatr48895"/>
    <dbReference type="GeneID" id="7194971"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48895"/>
    <dbReference type="eggNOG" id="ENOG502SCRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445147_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8S0"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="542" mass="60193" checksum="219CACC712BA04C1" modified="2009-02-10" version="1">MLRNNTVTLQARDVLALGGHKWSQMEPARYQELVQAALQQGVTTLEAGQDGGEAALLQAYQHAQMHQLTGTDRPNNQAVTVLTRVGYRTIAPPRGEADVVASASQNDDAVRSTTHSPATFFLPLDIHVEDIPAPESTDPKAATKSQVVHNVGKEYLQKAIRASPLLNTTTPHDLRIVPLLHNPEVQVILMQDKSPEQRQNRLKERLQDAFLALEEQIQAGTIASYGIASNGLGLPSTHPLHLDYRTILQAAAHVRDTLGHAVRLSVVQIPANVLETNGLAVARDLHAAVSADPDLLPHLELHCMRPLTCYPDAGTGTGHPFVVADYQIPATMEKKLSWTNEMTAPPELYDVALKSALQHFDAEEILQAKQDGIELSADQRETLDGCKLLQSLLHDVDVGLDNLRSFRAHEHDLYQKIIPLIHDTFESYDDETARVLQSFFAAYSMAVRYAIARNTRKLLQHGENHGKRTKEVPVYEDLPPTTRLQEFGLDFVLKAKVFDKLVVGCRQPDQILDDLDIVQRFLDGKLNVMEEKDTQDQSTTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Y1</accession>
    <name>B7G8Y1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183545.1">
        <property type="nucleotide sequence ID" value="XM_002183509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8Y1"/>
    <dbReference type="PaxDb" id="2850-Phatr48939"/>
    <dbReference type="GeneID" id="7195226"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48939"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_5_1"/>
    <dbReference type="InParanoid" id="B7G8Y1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="28129" checksum="36A87CA41FF49760" modified="2009-02-10" version="1" fragment="single">MARGKKKGGRRGDSSDEDHDTSNPAPPASTAPPAGPSKKSRKEKRQQKKSQHVEDEDNGSVDGADQLAALIAGTQYGSDSDDDDDAHDPYVAPPASQNNKGKHQKKINAKPKVHFQPSSDEDDDQDVDENEEADNASVADQDQDEDESVPQVAFQMADDDWGTGSSTKKKKKEKKEKKEKKHKKEKKKKKKKSSSDEDEDSPVEDLTEAVNDLNITHDEPKKKTKFELQMEAAMKKKEQEKVHETPPTIEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G972</accession>
    <name>B7G972_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">CCAP 1055/1</strain>
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    </evidence>
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        <source>
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    <sequence length="342" mass="39105" checksum="CE43E673B73E3994" modified="2009-02-10" version="1">MDDVGSVEDRRNPRSIDGDHNGMLVVRATPTNSTEFHRFPFLPTPALQKRSTNIMSETNEEMNARHRKELKALEGEKRAETKKTKSTAGKKAKAAIATLEAEYESKLKCMKERHGKELSDETPEFINTDYAANIEKTGGEGPCEPVIDTEEVERQRKVEKARLKREKQRQKELRREQEISKETANAGPLPREVENKIILQQLAPLNMIIAEVKADGHCLYRAVAAQCQSDYLTIRKMCSETLKAHEDDFAPFCEYTDTVPDFQTYVERVRSSADWGGHLELRAISMALKRPVWIFSSTSPHPLVIEEQSSDVDPIRLSYHLKYYALGEHYNQVINCTRPRPF</sequence>
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            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CCAP 1055/1</strain>
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    <reference evidence="3" key="2">
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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    </feature>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
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                <person name="Martin-Jezequel V."/>
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                <person name="Medlin L.K."/>
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                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183912.1">
        <property type="nucleotide sequence ID" value="XM_002183876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9L1"/>
    <dbReference type="PaxDb" id="2850-Phatr49132"/>
    <dbReference type="GeneID" id="7195638"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49132"/>
    <dbReference type="HOGENOM" id="CLU_453071_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9L1"/>
    <dbReference type="OrthoDB" id="49501at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="603" mass="64126" checksum="42661E53C67445A6" modified="2009-02-10" version="1">MAKSTASAKVLPASSRATKKGKLRPAEVTFSWPDDCPVQSEDPSDEGLAQPSLPPDPALHACSGKDIHVSKGATSQNSSSGSGNNTSKPTRYLAILPGTLTLRKPAKTNAPLFPESLAEKVEDSVVADAADSSDVNKPEVRLLGRLQHASSTHPILTTAAFSDSSCAPTQGSLSFRGTSVATTSKFLVLTLQPKKGKIVCKHVFSNVIVFGDACLHGTGDAVPSVAPTSAIDAVSGKRFSSTSDDRKAAVAVIATVEPQGTTSNAASLSHQKLEPQDTCKKGEDDESVFMATTEKKQGNLKRLSTGGEPLSDSSDSDRDVVRHPNLEVSAMLPASRRPRRASRKPVQYNTVESGDKDSDTDPSGSEDNSNIDCSGKRKQPIAKPMANKRTRRLLSNAITQSQEVINDLDESIDINISEENGAVAYKPASENSVRRDHGSARSTETGKLAESQPVCQNRRKSDANKQLEASSLSTSGTTKRHRIVQPATKTRPKSLSSNGQTELQKKVKLGKKSSFASPDIDSAMIVNSSVTAPENEAPSLPGSPVRQHRHPLTPSSSKKANKSTSTISSTPRKRRKRALAHATSPSKSRTIDLTLDTDLEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Z0</accession>
    <name>B7G9Z0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183975.1">
        <property type="nucleotide sequence ID" value="XM_002183939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Z0"/>
    <dbReference type="PaxDb" id="2850-Phatr49243"/>
    <dbReference type="GeneID" id="7195704"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49243"/>
    <dbReference type="HOGENOM" id="CLU_473695_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Z0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="576" mass="62450" checksum="28A1CC990BA8822B" modified="2009-02-10" version="1">MPAAGSERTMATPLPLPEAVVPAVSLSSRIARGVGSIWTTLSGHKRPAADRDDIAEGGPQRQVRARVSASPKAENGTFGSVPDDSVTNPLLSLPLWDPVVPPGFCGICLDTVLMPTSKVGSLPTCGHCFHVHCYAKWKAFCPSAVAFWRCPLCDQDASDFYKLQLFPQLEQADDDNNNNHEQSQDQVSRLPTPLERDEFHDAVSGVTLSGTLRKLVNHVSSSTDPHVVTRALDELSTLAFRYNHARVPICVTGGIAGIVRVLTTWSHDTKTTTTAALRHACQLLGNLPLNESATERIEIAICNAGGMDAILSIMQQHPDDVDLQEQAVFSLGKFICEDELLETNYVADQIPAIFRTMQRHSDAALVQTYGCYALASLTFREDVQEVVQMITAQHGIPIVLQALTQHVDDPDVVDAALNLLANLTEHDTSQTRGILESKSLKVLGRAMQNFTELVDVQMHGIVILQRILRLPDRISEAALMELGQAGVVVALTKSIDLYADKVDLQIGAIIILARLAPLVDLQPIMRDAGTPGVLRVTMDIYNDEETLMTHAYQVLSCCSESPVPAVAAAAAVDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAD7</accession>
    <name>B7GAD7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dsCYC6</name>
        <name evidence="3" type="ORF">PHATRDRAFT_49373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184058.1">
        <property type="nucleotide sequence ID" value="XM_002184022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAD7"/>
    <dbReference type="STRING" id="556484.B7GAD7"/>
    <dbReference type="PaxDb" id="2850-Phatr49373"/>
    <dbReference type="GeneID" id="7195885"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49373"/>
    <dbReference type="HOGENOM" id="CLU_067459_1_0_1"/>
    <dbReference type="InParanoid" id="B7GAD7"/>
    <dbReference type="OrthoDB" id="64224at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="362" mass="40776" checksum="2FA70CF602E557AE" modified="2009-02-10" version="1">MEAIPVTPAKGTAIQGQTSFNRKVRHMDKAPVMEHLRVLRRLESETYPPCEDYLTLFGPSHTEGVTGYISERWRGSICEWCYEVVDHFQFDREVVSIALNYLDRAVAAKARDTLKAIPYLEFQLIAVTSVYMAIKLHGAHETHDGPRRRLRIDAFVELSRGHFEAGAIECMERSILSTLNWRVNPPTLLRFISNLLELLPEWSPLPHTVSYGDALGGIYDYARYLSELSVCVSKFSFTLSSSEIAFSAILCAIEALQATRTVPDFARSDFLKNVAEATGLHADEPQILSACEMLRELYPSIFGRDDEHHLFASHACTVGQPQSVSGKKSPVCVLEEQAESPNTRRKRSRSSDDDKQPLYSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAI1</accession>
    <name>B7GAI1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184201.1">
        <property type="nucleotide sequence ID" value="XM_002184165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAI1"/>
    <dbReference type="PaxDb" id="2850-Phatr49411"/>
    <dbReference type="GeneID" id="7195905"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49411"/>
    <dbReference type="eggNOG" id="ENOG502SNPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453805_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAI1"/>
    <dbReference type="OMA" id="YLVKCEY"/>
    <dbReference type="OrthoDB" id="43834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="602" mass="68103" checksum="2A1CEDAA818B6C52" modified="2009-02-10" version="1">MKSAIVSFLAGLWKEEEESERMQIQAVPGLMTLLDVALYRTVEGQLTATIHASHQILEAWLDVKRQAVTVLQALRKELDLNATRRIQLDGFARTALDAACDAVERLTTDKLAQTANLSDPFPQQGTSGNAGSGINHHYSHSISANLSHLDESSRNDTGRRIPMRQRGKDCWESPRLHCPDYVWAEDFSQACHRLIKHLYKHPFLGDDPVETSTVLANAPRKSFLMSADTEHEAQILVRLLKTDIPVRLYQFRASMEADSVVSKRLYLVKCEYRAPFRAFLEAHQSVQRAPSLELVGEYTSGSNRKVATRREEAKERLSKLLETPCLVKSLALEQEIENSELEIAKILYPFCELARYVEHKNARLRSTSGLVDEDNVIELQDLLRRLKGLLCRRTTLSTETSAGIRPLLLDLQCLPRDEDGFTPYQTPTAERVAQRATELVNELQILSKISQKRHVFATEGKHELDLRPSISRGCNDLDGELLHALIVDWFSMVHRQHEVIGETDFQELAEKLRHAEMQMSLAVATNQSLAAVRDRLNLIHKDREMKFQVLKETLEDLSLREMNLDIEVSSPDRHRMLSLQPTSALGVFGQAMQLAGEALPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAK1</accession>
    <name>B7GAK1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184091.1">
        <property type="nucleotide sequence ID" value="XM_002184055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAK1"/>
    <dbReference type="PaxDb" id="2850-Phatr49431"/>
    <dbReference type="GeneID" id="7195918"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49431"/>
    <dbReference type="HOGENOM" id="CLU_1581582_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAK1"/>
    <dbReference type="OrthoDB" id="10615018at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="169" mass="19719" checksum="F870BC09359D0806" modified="2009-02-10" version="1">MGESRYQDPAYSVMRGADGRLYRFPISEQSREDSQIVRGSDGRLYRLRKTVEDDAYSPPLAGQKLYRDEHTVRKPIRRELQLEEESLPSVDEPLHFAASTRQPFMPVTESLRKPSRTLEKIPSKPRRKRITVVVEDASDSEYENDEHKSTWRNRVPSPNESWMEPISMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB28</accession>
    <name>B7GB28_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184300.1">
        <property type="nucleotide sequence ID" value="XM_002184264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB28"/>
    <dbReference type="SMR" id="B7GB28"/>
    <dbReference type="PaxDb" id="2850-Phatr49571"/>
    <dbReference type="GeneID" id="7198190"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49571"/>
    <dbReference type="eggNOG" id="ENOG502RRCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299863_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB28"/>
    <dbReference type="OMA" id="GANECAW"/>
    <dbReference type="OrthoDB" id="48824at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856037" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1000" mass="104580" checksum="B80165A932C81339" modified="2009-02-10" version="1">MRGIFFAASTLVLGIASFRATDAQDVSCQLVRQPNGSVEYVCDQVREPMRPPLVPDGQTYQQGPVEKYYLQQPAEDVNASANATIPILRRVGVPPFDTPLQACQGSCGSDADCATGLVCLDQLDRPRDGSVQGCSGNGRLTMSVCVVPGSEVDLKIGSLSLEKCQGTCSSDDDCAGGLACFRRQGTETVPGCLERDVSESNFCHDPNETLARLAFVGAAPHSQSSLLPTCSGSCSSDWDCVRGSNCFRRDGTESVPGCEGRGLSGANYCYIAPEGSLLLVGDGVTYIQYPLRQCEGHCIADIDCESGLKCFRREGSEHIPGCDGEGADRTNYCYQPFPDTSGPTDGPTLAPLSVSPSNSPSLILTLDPTNSLGSRGGESESPSTPTSDMPSISPSDEPSMIPSDTPSMVPSDVPSMLPSDAPSMIPSDSPSDTPSDVPSDVPSVLPSFSPSMRPSDTPSTMPSDTPTDVPSDAPSDSPSDVPSDVPSDAPSDVPSDVPSDAPSDVPSDTPSDVPSDVPSDTPSDVPSDVPSDTPSAVPSDVPSGNPSDVPSETPSDVPSDTPSDVPSDVPSDVPSDVPSDVPSDVPSDVPSDTPSDVPSDVPSDTPSDLPSDVPSDVPSTMPSSTLGGTSSNGPVTGKGSLAPTGSFSGESSGRPSKTPGVMVELSARPSESFTPSPTTFPVLLPSKVPSIAPSRTETVAPSTAFPTETSSSLPTLTTTVSSAPTQMCSMSASERASTIMGILEEDFNDVSSPQFRAVEWLVQIDPLSLCPGDENLEQRYILAVLYFQTGGEWWTRCSPMSAEVCDQGEAFLSGANECAWGGVNCDSSSRVTALHLDSNNLSGSLPSELGRLAYLVELDMDDNELTGSIPRILGQLSFLEIVDLDDNQLTGSIPEELYSVSSLEILDLDINQLTGTISTLIGNLVNLYYLQIDSNKFTGSIPSEVGTLTRLEYFSMTDIQIAEALPDSLCSRDTLLLFGDCEVCVVEDCCTACLAKETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBF9</accession>
    <name>B7GBF9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_16073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184362.1">
        <property type="nucleotide sequence ID" value="XM_002184326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBF9"/>
    <dbReference type="FunCoup" id="B7GBF9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBF9"/>
    <dbReference type="PaxDb" id="2850-Phatr16073"/>
    <dbReference type="GeneID" id="7198316"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16073"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="B7GBF9"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="52463" checksum="F7EE9F5EB9681A18" modified="2009-02-10" version="1" fragment="single">MGFDRMTEIQAKTFDAASLGKDVLGRARTGSGKTVAFLLPALERLLQDNNNKSNKKSTRMLVLSPTRELAQQIAEQTRLLTAHMPNMSHQVMVGGTPKPKDVSAMKRKVPTIIIATPGRLQDHLESTVVHNTPFKDLFRELDVLVLDETDRLLDMGFRREIDKIIKYLPRNKQTLLFSATIPEDVKHVIRQTMRDPYITVDCIHDDQAESSSHTNAQVSQAHVILPTNTRMASGTVDIIRNILEKQPHSKIVAFFPTANLVAFYASLLRDVLEIPRILEIHSRKSQSQREKASESFRKTNHGCLLTSDVSARGVDYPDVTHVLQFGVADSRESYIHRLGRTGRAGKLGQGILVLTDVERGFLRHLKGLDIPVHPELQAIVDGPTVESQQDLAPVWASIGSGRNADLALKATKAYVSALGFYNTHLKARCGVKGTDALVAFCNAFAYQVGFTTLPPIEKKTIGKMGLKGIQGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBG0</accession>
    <name>B7GBG0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184363.1">
        <property type="nucleotide sequence ID" value="XM_002184327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBG0"/>
    <dbReference type="PaxDb" id="2850-Phatr49682"/>
    <dbReference type="GeneID" id="7198164"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49682"/>
    <dbReference type="HOGENOM" id="CLU_611749_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBG0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="49163" checksum="0A065A2D8AF01343" modified="2009-02-10" version="1">MVVDFRGPRRQPEHFSKELRIDCSDGTSSMEDSARTRTQIQSSSSIHSSPDPEDCYTPVLPCDDVGMPWNRLDAAFDNDRIHRSPSGGDLSPVLRISGSVGTEHNLSNPLYIASGENVAAAVAQWYAPGVGPADGPGGMVPGTPRTILKVQALTRSAAHGVELALLLPAVTGCSVDELQLQDFDWRVNDVNALCTSDSGTKRVRIQHGSMSDAAVHALARDLVTAPTLGDDKPVSLLLDQVDISPRALQGLFASVARAPKLISLGLVAMQMRNNVLLNAFTQSLSTNHSLHELDLSWNTFSLWQWKELCRAVREHCSLRILKLNWISHGTQHRDDECIDELSRTRTTALLNMVQANPNIQEIQLEALRDSDYDTALLDCLQSGLTVRRLYQHRVAALADQDTSGHRRALLLQSLVHAQQSSCRHDLFFCILTQSTDALAIERGQPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBK7</accession>
    <name>B7GBK7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lhcf5</name>
        <name evidence="19" type="ORF">PHATRDRAFT_30648</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184620.1">
        <property type="nucleotide sequence ID" value="XM_002184584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBK7"/>
    <dbReference type="SMR" id="B7GBK7"/>
    <dbReference type="PaxDb" id="2850-Phatr30648"/>
    <dbReference type="GeneID" id="7198479"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30648"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_4_1_1"/>
    <dbReference type="InParanoid" id="B7GBK7"/>
    <dbReference type="OMA" id="KREIYCC"/>
    <dbReference type="OrthoDB" id="39049at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000011">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012022660" evidence="18">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC44019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="197" mass="21245" checksum="3D94B51863F2AFF1" modified="2009-02-10" version="1">MKFAVFASLLASAAAFAPAQQSARTSVATNMAFENELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVAGYLVQENGIRLPGDIDYSGTSFESIPNGFAALTTISGAGIAQIVAFIGFLELAVMKDITGGEFVGDFRNDFIDFGWDSFDEETKMQKRAIELNQGRAAQMGILALMVHEQLGVSLIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBR3</accession>
    <name>B7GBR3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184491.1">
        <property type="nucleotide sequence ID" value="XM_002184455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBR3"/>
    <dbReference type="PaxDb" id="2850-Phatr40515"/>
    <dbReference type="GeneID" id="7198427"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40515"/>
    <dbReference type="HOGENOM" id="CLU_2150757_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBR3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853197" evidence="2">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="112" mass="11773" checksum="0FF5228B264ED2F8" modified="2009-02-10" version="1">MSTSVVGFLCLLLLALVFGSSGAAPVIAVVSTPTSAVGVPIETVTASAFPKQAADVLRQSIQQQSRNLSSSKQRMHPCPRPSGGHKSTCSRPGPEILAKPQRMFWKAVRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCE4</accession>
    <name>B7GCE4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">Adenosine kinase</fullName>
            <shortName evidence="14">AK</shortName>
            <ecNumber evidence="4 14">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_51242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 14"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184793.1">
        <property type="nucleotide sequence ID" value="XM_002184757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCE4"/>
    <dbReference type="STRING" id="556484.B7GCE4"/>
    <dbReference type="PaxDb" id="2850-Phatr51242"/>
    <dbReference type="GeneID" id="7198639"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51242"/>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045832_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCE4"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000076">
        <property type="entry name" value="Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="15">
        <location>
            <begin position="37"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="36727" checksum="82A272500980529E" modified="2009-02-10" version="1">MSKFTGLLMGMGNPLLDISANVGQDVLDKYEVKLDSAILAEEKHQPLYPELIKNYDVQYIAGGATQNSIRVAQWMLKDKKGQTAFMGCVGNDEYGAQLEKCASDDGVLVHYMKDETTPTGTCAALIKDGERALVANLAAANNFKETHLTTEKAQEIIDAAQFYYCAGFFLTVSVESLVKVAGQAVEKGKTFCLNLSAPFIVDFFGDQLAAALEFADFLFGNESEAEAYGKKNGMGEDLKEIALKICALPKKSSKPRTVIFTQGSKSTIVACDGKVEEFAVEALEADKLVDTNGAGDAFVGGFLSQLIQGKDMATCVNAGHWAARYIIQTSGTTLGATCDYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCI3</accession>
    <name>B7GCI3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184877.1">
        <property type="nucleotide sequence ID" value="XM_002184841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCI3"/>
    <dbReference type="PaxDb" id="2850-Phatr49982"/>
    <dbReference type="GeneID" id="7198770"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49982"/>
    <dbReference type="HOGENOM" id="CLU_461920_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCI3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="614" mass="67618" checksum="5FB0618AE5092C77" modified="2009-02-10" version="1">MSERGLSSPRGKSTFPVIRRNSFNESEYSRSSYESLGLVDHVHRLEALLSNSLETSSTLQTCVDEDDDLAAELKRLEHAEQLLRQELEDLEVNGVPKPDSSTQGVFSSDNRARERTLSASREELTVSNVEDDDDDADDMFNYMLNFTTGASPLSTSKGRLKTDSDRFDAISTPPHTPPRTVLSPLRQRRLDVLGLDDNASFHEQSCAQEDGNTRRSSSWSVEDWSSYNQPSEGSLESESIESGSVFSNLGVASVDRSSSFPVDVLARGDVDDEDKPVKATKVDVLADGDVVEVEEIDEVPLEAADTLASSTPWARRRIHNQTEMQQSKSTTPIISSRSITTSADTVQSSSIEVSRSPSSAAIPKRIPAITPRHTKTPEYDHFQGPDTSSQHTIPTRKSSRKKNEWSAMLSHSGKAKVILRPLANDRPATTRDNSMSPRLFPKTRNSPSAFGNGHAVETRGILQTETYPSSISKCDDPQRFEDLQSFGAGSQNPAQQQANDESTSRRVGSLVSAAPRQDTRRPKVPHRIAMGYAHHQLRDDDDQDAQVSTCGWKFGGERTSNGIFFCLALIALVLTRSPCSAVAARKATLRYSIDYYSTGGAPHLAGILHLFQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCI4</accession>
    <name>B7GCI4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_3656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184878.1">
        <property type="nucleotide sequence ID" value="XM_002184842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCI4"/>
    <dbReference type="STRING" id="556484.B7GCI4"/>
    <dbReference type="PaxDb" id="2850-Phatr3656"/>
    <dbReference type="GeneID" id="7198692"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3656"/>
    <dbReference type="HOGENOM" id="CLU_251658_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCI4"/>
    <dbReference type="OrthoDB" id="48557at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065:SF75">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065">
        <property type="entry name" value="OS10G0469600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="54"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="26552" checksum="61E68E517ECA77E5" modified="2009-02-10" version="1" fragment="single">FIEGRIPPEFGAMTNMETFVLSGNKLTGTLPTSLGDWSNLRMLNLNGNRFTGTIPRAYSFRSLTSLDLGDNLLYGDVPASLFSTSSKLVKLVLAKNSLRGTFPASLGELSSLETLQAADNEWNQFPLEVTLLSSLVQLDLSGNVFGGLLPPQIGNLSSLRELFLNGCNFSGGIPPELSNLTNLERILDLSDNSLLGTIPSSLGNLVNLRRLFLQNNKLSGGVPSTFASMTNIKSIRLESNSLTGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCJ2</accession>
    <name>B7GCJ2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184818.1">
        <property type="nucleotide sequence ID" value="XM_002184782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr40832"/>
    <dbReference type="GeneID" id="7198697"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40832"/>
    <dbReference type="InParanoid" id="B7GCJ2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25424" checksum="894AAB801E585AB2" modified="2009-02-10" version="1">MPETRDKKKRRKLCIPPVCSATGNTSENPNMEAGAVRDRNEFSCFTRFMSFFNPLNVARMRERSDDDEYDDSEWESRASMLSRKRKPIRPPSSDDDRKPAAKTPGNGTATAPIDLTGTSSNGTSGTVDSVKGQSTSCITPRPVDQMDLGTLEVLARFPSLLAGGRFCKDVLGVWSVRKFQNAMGRGHPDAVTYAGFIWKRMGQPDLDINNLPPAIEEARKFHLLALGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCR6</accession>
    <name>B7GCR6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184846.1">
        <property type="nucleotide sequence ID" value="XM_002184810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCR6"/>
    <dbReference type="STRING" id="556484.B7GCR6"/>
    <dbReference type="PaxDb" id="2850-Phatr50050"/>
    <dbReference type="GeneID" id="7198743"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50050"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566814_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCR6"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="482" mass="54279" checksum="57CCE0EB7E3B12A2" modified="2009-02-10" version="1">MQSPNGNNCSINPATPVRSTSSTAPPSKRRSVRRPNDDLELMLQHENFPHLLNLAHKIKTAHVRIQSVTTGFEPSQALAKYSLAPSEVMEAVTRLQNQFVSSETSRETIRPGVYPMTDILVMDSIETLQREWEHCQKWLEASESTRLDKDPTAEPAVSEPPTLPKKRKASGANSGSKKEAIAVKYSKWQTDILMNWMIQHVDEPFPKQGEIHQLMDMTGLTQSQVINWTTNVRKRNRKATCQNGKKPHHFIDFVFLAHDRERRARKASSIATAHPLMTGLDSFQNAPRENILAVPPSPSACAVPTRQAASSYSYPSPPSYPQPTYNHTSLSYFANQTPDFKCVHTVPFSPGTMASSPPRCAEDSAIQEHSQTLMQEEMWEIHDDFDPVPMEEESDEFIMEEFAKSWLFENPMDVNDPDSLTVQQAPCSTMPRLNDLGLLPSVTEDSHEKLHRNRTASFDLGELEDEDIDAWAADMGLTIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDW5</accession>
    <name>B7GDW5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185327.1">
        <property type="nucleotide sequence ID" value="XM_002185291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDW5"/>
    <dbReference type="PaxDb" id="2850-Phatr50367"/>
    <dbReference type="GeneID" id="7199189"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50367"/>
    <dbReference type="HOGENOM" id="CLU_1075450_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDW5"/>
    <dbReference type="OrthoDB" id="42752at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853175" evidence="1">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25125" checksum="A57778A28FEE67A8" modified="2009-02-10" version="1">MHTATLAVVVGAAVHSLFNTVKCAGIGTNPVQWRQQWAVEVVKIANGIVHPKDYARIQPKERRGNDDNSNPTILTRPFLCPPSGWRSPPPLPSQPDFICNYNSTMITVQNTLTALVYAFDTASQKQQEADRITSSLFLLCLPGLQLVSGVGTICLDQLEARQYDFEHTASGMDDAEEDFVHQPSNDSLLPALTYVAGDHPLMTSLLAAPDDCFWIPGRPVTSGCRICCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE37</accession>
    <name>B7GE37_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_50431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185366.1">
        <property type="nucleotide sequence ID" value="XM_002185330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE37"/>
    <dbReference type="PaxDb" id="2850-Phatr50431"/>
    <dbReference type="GeneID" id="7199300"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50431"/>
    <dbReference type="HOGENOM" id="CLU_663024_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE37"/>
    <dbReference type="OrthoDB" id="47969at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="415" mass="45621" checksum="768A47BEF73E0F2C" modified="2009-02-10" version="1">MAALETNDTVDIGSRIDLTSLGRDLDRLTLAAEPSDAFAPKDDVAPPPSVPLPAPSSQLVREIKESGWSIFRPLADLGYFTWRPSSRRHKSLRDVSAEEVRQQVDLQALPDRLVDVYRLPLPVPFLTDNNSKCTYVNKYPLGQFDVAGLYAAARRGLRFHHEKIDFCLGGSTLNMLATRDDSSPYFACMIAGTKTILVSKQKEYVRNLADVGFQFERLVTGRAMNDWNVTTVVNGNASVASHNLECLEHLHVMQVGSYRVLFRAETDAVDEENNPVEIKASHPRYWKKATMLQMLSSGSTTLCRGVKGRGSLSSVNTQSLVQVSAKALGDRSSGTREALERLILEGMAALREQLQCAGKVYKIVFPLASVGGRNSHGGLPGKLRLIPAIGRRAIVLPSDKVLRELLAVPTLLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE97</accession>
    <name>B7GE97_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_50493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185446.1">
        <property type="nucleotide sequence ID" value="XM_002185410.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr50493"/>
    <dbReference type="GeneID" id="7199281"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50493"/>
    <dbReference type="eggNOG" id="ENOG502RRCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257215_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE97"/>
    <dbReference type="OMA" id="RFPMEDT"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053271">
        <property type="entry name" value="DDT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15546">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN, 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15546:SF2">
        <property type="entry name" value="DDT DOMAIN-CONTAINING PROTEIN DDB_G0282237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="953"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="771"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1358" mass="150600" checksum="3C3EF09A32BE069D" modified="2009-02-10" version="1">MKSGHAKAPRANPAWPADSNGATVVKSTTTTTTNTPPPSVTEGTPRKKATTNKLPRRTDTADAPTPASSSATPATLEPTTNGHSHHGTAATNANGNNATKPSRKRNSSLSGSKTYLQIIHEAILALGDRTGSSIPALTKWILQEYPQLDGPQFKNRILQAVKSGTKAERFQKVKCSYKIAAVFKEKERQAARKKKNAVAAAAAAAAKKKKKAATPPTLAQTQAAHEQKLAQLQKSLSPEALARKKVDLARQEEATRQRLQAEKVAKERADRLRRRRFPMEDTRLHQEDAELHVKPPADVLARPYLPYFWYMTTDLHDPSRHGKTSSQILQASKVDGLDTGNHGLVPDLLGVYHFFRGDVQFRIPDERELVPPFSLAQLVFATEQILNGNAKRSRIVPPLLSSLFCTCLQILCRAPEDTAEKTSQTQLQKDLHRYLAPALTPASWADVLYLYMDAMERFYATDASRDPNVLPPLQIDVEYLLAVRDDIVVPMTPATTVKGKSSETNLNPLPGGYFAYLGDPRGILFRAFSKLGRQDPWLLTAEELIVLLRVLTDDILASHPAISQDVAAREEEMLALSKAKRAADTKLRKVRLAFEGPKKPATATVKKPEENKEVTKDEKTSETENQNGNEDEKEEILFKPTATQKQLESAVKAQQKASEAYEKGIRKLTARTEPIGYDRNFNAIYCFRHDPEVLYVEDLRQPSTVANHLPLDMQFKRRSWHLIETTALFDSFTGSLDIRGRREHDLYEELVGPQGAQQSLRRFLHDNMKEQNEAVARVRELESLKKRLEVARVKCDEEQGRRSGRLAGQAGEELSSLEFQIEILESRINGTSAPEPRDYEELTGLTLLRKFDSNSGMGARRTREQKQQTKTHNLPILPCSKMCGTGNIDGTGLVGLLVSGLLEVEEICETLAPWERTDTTRGEWVARLENAVHTWNAVSPMVLGLADAPPMKVIGSPAQSSPPNGSSGVQRSARRTSLDSLESASKKRKVETPPPTSTTFHSAANIVSMIRQPLIDLEARVAAITNLDVASKDADIADDNLSTDGSEDDQAIKEKLERAWKRQIHRLRNTLTHRYGQIREFLVAAIAAARKAHVPEVVAELRAALLQYHPGAASECKYAAIKVLLAHGDYEPDEDEEEEEQYDVREEGDEVEIPSVICAEAAMLASSLDGSEDATRADWIDSVKACKTISRLASLVGAFVKNAQDKMGKLEDERDDLLAAIKTWEKEEERRVKNRGGKKPVGRPTKDSVGPSEVWANVRFSDEICMAKAENWPWWPARKCTPKDGSLARSLAGLDRSLVALIGEMGGLRVVKTESIKAFSGTLVEDEDLGQYNKSVRSQLDDCMAMGRRIARGMEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GER4</accession>
    <name>B7GER4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_55229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000635">
        <property type="protein sequence ID" value="EEC42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185594.1">
        <property type="nucleotide sequence ID" value="XM_002185558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GER4"/>
    <dbReference type="STRING" id="556484.B7GER4"/>
    <dbReference type="PaxDb" id="2850-Phatr55229"/>
    <dbReference type="GeneID" id="7199473"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55229"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="InParanoid" id="B7GER4"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF117">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="379" mass="40580" checksum="31F411B0E2F76B06" modified="2009-02-10" version="1" fragment="single">MADPSDLEAFKWRRVVVVAATNRVEAIPVSLQRPGRLEREVSLFPPSIAERISILQFLLRDSCKACLKPEEVEGLAESCVGYVAADLVSLVRHAKLLRLFQDVTEKHDSVGLTYHLLKSATKEVAASALRDASLSAPPNRSWKDVAGNPGGAKTLLRQAVEWPLSRRCAYECLGLTPPRGILLYGPPGCAKTSLARAAAGASNVAFLSLAPADVYASSYIGEAEAIVRRTFALARSAAPCVLFFDEIDAVLGSDGKAGHSMSRGSSAEARVLSTFLNEMDGVDGESKDGVLVLGATNRPWTLDVALLRPGRFDKIIYVPPPDFEGRQSILNLACREWIDLGLAPDIDIEILASEGVSGNLTGAEIVGACREAASDVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4G8</accession>
    <name>B7S4G8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999287">
        <property type="protein sequence ID" value="EEC42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176461.1">
        <property type="nucleotide sequence ID" value="XM_002176425.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4G8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1101"/>
    <dbReference type="GeneID" id="7204861"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1101"/>
    <dbReference type="HOGENOM" id="CLU_609015_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4G8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="480" mass="52765" checksum="FDC68B7C63820795" modified="2009-02-10" version="1" fragment="single">MVSTRSVRVQPPSEGGPVGADDPSVGDPPPSDDDGEDDDDAGTEPSNGSSLPAQVIRVHQTPRFSISPSLSQGRRAILDYSIPKIAKLYVSATKPLSKTEFDIKAGALTPLLSSLALRAREHGRHGHGSNGILKIPNNITIPNGASKLLIKEYGQISLPHIRNYVGTFANTETREVQDDEALYQCLKVSLTHEAMAKIDLYETEWTVAGEPSGVAMLKVIIRQAYIDTNATTMHVCTKLSKLDSYMESLAEHNVTLFNEYVYEQLHALTARGEQTLDLLPNLFKGYEAAKDTQFLEYIRKKKAEFEEGTVFLEPEILMSQASIKYRTLVEKGEWDAPSESEAKILALTTQVKELQAKKSEKPKSKAKGDSKGKKKKGKKSDKPKTDKYASLKKPSASEPHTKTFDGDKIKFCTNHQAWGMHLASECKGYGLEKDSNGKPIPKGSEPNATDKKGPPSKLHAAIMRMSKALTTKIEKAKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3A6</accession>
    <name>B5Y3A6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_46636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185615.1">
        <property type="nucleotide sequence ID" value="XM_002185579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3A6"/>
    <dbReference type="PaxDb" id="2850-Phatr46636"/>
    <dbReference type="GeneID" id="7204478"/>
    <dbReference type="KEGG" id="pti:PHATR_46636"/>
    <dbReference type="eggNOG" id="ENOG502QZRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113159_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3A6"/>
    <dbReference type="OMA" id="PSIAHIN"/>
    <dbReference type="OrthoDB" id="6081786at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="250" mass="27107" checksum="6F2344412D295517" modified="2008-11-25" version="1">MTTSQEDEPLLNPQIAAAAAVSGAGFINSSTEKIKKARAEGPLTFRTLGFLGGLAMIISNGLAILDRFFSFNFAGAMIAFYGVLFGVIITMLEAPGPCSQRLQGGIRFYAKFLDFTWGRGALYFFVGTLQVSNWNMLDWAVGGFMIFVGVTAIGVGIAAARDLRLLKFAIQNENHLKEKWNQHDADGNGTLDAKELTAFVADAGVDMSRNEIAATFLALDKNFDEKIAYEEFFSWWTAAGTYGAGTSMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3B2</accession>
    <name>B5Y3B2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myo-inositol 2-dehydrogenase putative</fullName>
            <ecNumber evidence="5">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_3639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185618.1">
        <property type="nucleotide sequence ID" value="XM_002185582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3B2"/>
    <dbReference type="STRING" id="556484.B5Y3B2"/>
    <dbReference type="PaxDb" id="2850-Phatr3639"/>
    <dbReference type="GeneID" id="7204481"/>
    <dbReference type="KEGG" id="pti:PHATR_3639"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_3_1"/>
    <dbReference type="InParanoid" id="B5Y3B2"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="37772" checksum="8CA5DA9E83DE6D42" modified="2008-11-25" version="1" fragment="single">MNVEAVDTKEIIKVGVIGMGRIGLVHLEAITKAPGVTPVIVSNPTVSKAEAAAKQYNIPRFTEDAMEVITDPEVDAVWICSPSQFHAEQIKACAANGKHVFCEKPIATDLPETVEAINACNEAGVKLMIGLQRRFDQNFKRVQEAVTQKEVGEPIMIKLCSRDPSPPPASYVKGGGGIFADMAVHDLDMSRFLAGSDPIDILAIGSCHIDKTIADFEGSEKFDTASCLVRYPNGVQAMIDVCRQSSFGYDQRAEVLGTEGMIQTDNVYPNTAKIYKSHFTGNADMPYDFFLSRYNEAYVTETVAFCDSLVNDTPVPCTGEDGLVALIMAIAADKSAAENRWVTFREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3E0</accession>
    <name>B5Y3E0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185828.1">
        <property type="nucleotide sequence ID" value="XM_002185792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3E0"/>
    <dbReference type="PaxDb" id="2850-Phatr46667"/>
    <dbReference type="GeneID" id="7204587"/>
    <dbReference type="KEGG" id="pti:PHATR_46667"/>
    <dbReference type="InParanoid" id="B5Y3E0"/>
    <dbReference type="OrthoDB" id="47730at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF1">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="2">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="407" mass="45002" checksum="FDE0DE1AF001C1C4" modified="2008-11-25" version="1">MNSYLALVPRGLQHVVQSMLHEQLTRDGRSTMTVRVDVVGQVEYDYGADGDRDESEAKYAQQMRDKLVAHQSSQQRKGKKRARQNESTGTATCRAPTGTMHIDQTSTLSVGYDDTRIVWNTPGALQGVVWLRIVTNATTTLVDSLRCVGPLLLLVDLWEEQNVNISESQSIDQALQVFQQHCKQDMFDSVLQVWERVAKRIDTESAFREGAGTVSTELPPQRHFVIPDKFGKTWIVDLENYDIEIVLLLRSNRVAIGLATRPYQYLGAKSFDKGALPPDVSRPYLSGQVLSKVLRLRPSTAQILLHQAKLQPGDVVLDPCVGIGTIPLEATLQGIPVYAVGGDLVLGHNQLGPIAARYVRECRTVQRTESQSSGAADLLVWDACLVPMRDGCVDVIVPASVAENYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3N7</accession>
    <name>B5Y3N7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_50995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185690.1">
        <property type="nucleotide sequence ID" value="XM_002185654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3N7"/>
    <dbReference type="FunCoup" id="B5Y3N7">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3N7"/>
    <dbReference type="PaxDb" id="2850-Phatr13382"/>
    <dbReference type="GeneID" id="7204642"/>
    <dbReference type="KEGG" id="pti:PHATR_50995"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_2_1"/>
    <dbReference type="InParanoid" id="B5Y3N7"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050262">
        <property type="entry name" value="Ribose-5P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748:SF3">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841247" description="ribose-5-phosphate isomerase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="287" mass="30402" checksum="76BF5088F038F305" modified="2008-11-25" version="1">MRLTAGASILLASSAHAFTNPAFFPRTATFASTSSYTSALILKMGVDQDELKKQVGYKAVDDYVKSGMVVGLGTGSTAYYAVERVGEKLKSGELKDVLAIPTSIRTKEQAESLGIPLVTLDTHSKLDVAIDGADGVDPELNLTKGGGGALFREKIVEICADKFIVIVDESKLCDGLGPGFPIPVEILPFCHEHTMRVIGELPSCKGCKPVLRMGSSTNNQVDGDEIAISDNGNYLVDLHFEDPIKDPAKMAQELKNVVGVVEHGLFCGMSTAVIIAGADGISVKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Z7</accession>
    <name>B5Y3Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_46853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185750.1">
        <property type="nucleotide sequence ID" value="XM_002185714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr46853"/>
    <dbReference type="GeneID" id="7204710"/>
    <dbReference type="KEGG" id="pti:PHATR_46853"/>
    <dbReference type="HOGENOM" id="CLU_450169_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Z7"/>
    <dbReference type="OrthoDB" id="48725at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="66712" checksum="F175B7CBC44EA829" modified="2008-11-25" version="1">MPRVGIIGMRRAATVAEAAAAVSALSPESRRLSGLLGLLDDSEEASLTLVESVSILPTSRQIKTFGSMLKSSIEKLRRHTWEALKAPEQEMAMAAERCFRAAFGLTQPPSQPIEKKATRPPKSGYHLFCANYSAECTVGGNFGGRSAVLQQASQAWNNLPEAEKDVYERRAENQKGNSLMELPNPTPQSTFSATVATALISDSEDGTQTATGTLVPTERTAQIKRDFQRMDFWNSFLEAVHLQVASRTTKTWGQKKRYEIYQLAGPVMPTESFKLVRQQISKAFLALYDGSRTNHVAQVRHSQCRVYLLEQDGRMWIQVNIGRALDLTDECSKSSVSGRKKRKPDSEFIALVRPDHSLIALTASRTPSSSKFTPFVLSALEHALTCSIVAKDEQLHRFEDLCGTEPTNLLELAIAIENKQAVGRYKRLAVDGEIVNPIKELQISATASLLSRENDSGRLDVGAKLGRVIASRAAAVSENSMKASDLIATKGNSMLLDLDACEKGLRKRKREVALGLPADCPPREYVRWEWKGETNAAQACWETEPIEPELTSFKCRIVCQGTNVFAGMHELIQAGYMTEVLPHVKAAMSIGGTICVDHGTFSGHKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y483</accession>
    <name>B5Y483_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_36992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185793.1">
        <property type="nucleotide sequence ID" value="XM_002185757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y483"/>
    <dbReference type="PaxDb" id="2850-Phatr36992"/>
    <dbReference type="GeneID" id="7204457"/>
    <dbReference type="KEGG" id="pti:PHATR_36992"/>
    <dbReference type="eggNOG" id="ENOG502QYH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726601_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y483"/>
    <dbReference type="OrthoDB" id="44644at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841254" evidence="1">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="44483" checksum="EED8A8884BF08A0A" modified="2008-11-25" version="1">MSKRFRRKAFLFRVCFLVLAGQVLLLCHRWAEEEQQEHYSVEILPRIHFTPAESNLSLKSSSALITEPSFSSGSQRRDELSDTLWPADTFRNRTLVVVLGSLRCGEAAWKSLYRNVLDVNNADLAVITQAKPKSDNSRHTVSLLQRAKYVWEVPSFTDWADALDLMAGGRAWRERVPEYYTDHESGILGGALNYSGSGAIIFWYRWFLTERIRELNWKSRYDRFVITRSDHFYLCPHDINELDPYFMWVPQGQTWGGVTDRYLVVNASNVLEALNILPPLLKNPSRYSNYLQRKVNTEHFLAMRWREQSLFPDKRNKFPRTMFVCMAREDALTSWKPLGIEVFPGVFTKYHIEFSTSQQACRMSRQERLDFIARKSNLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4I8</accession>
    <name>B5Y4I8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_33163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186018.1">
        <property type="nucleotide sequence ID" value="XM_002185982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4I8"/>
    <dbReference type="PaxDb" id="2850-Phatr33163"/>
    <dbReference type="GeneID" id="7204276"/>
    <dbReference type="KEGG" id="pti:PHATR_33163"/>
    <dbReference type="HOGENOM" id="CLU_935279_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4I8"/>
    <dbReference type="OMA" id="STWFRIT"/>
    <dbReference type="OrthoDB" id="46984at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="34061" checksum="5C70B35192A85826" modified="2008-11-25" version="1">MVVAQRLQKHSHAVWTDFSSSQPQAIAIVLGHLGVSDHTLHRYAKWYVNRSSSVVAASSPPHIFARNGSLRDTTEQILAQTVRALHQAESNSQAPRNLPPIVVHLFSNGGAFLLQDFEKLLLEKSNSDSERATRKRVRQQLALGYQIFDSCPCYLRVWGDNMYWKDSFPHPQLSRWVRMIYARMSMAFLSTWFRITTSFPIRTLPAAFWSAMKTSRACPYAIYVYSTRDLLSDASAVDRLIQYRRQQSGGKILCDVHRYDDSNHCRIDKDHPKEYGQMIDKALEAAVQRATCSQLDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4L7</accession>
    <name>B5Y4L7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186034.1">
        <property type="nucleotide sequence ID" value="XM_002185998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4L7"/>
    <dbReference type="PaxDb" id="2850-Phatr33195"/>
    <dbReference type="GeneID" id="7204289"/>
    <dbReference type="KEGG" id="pti:PHATR_33195"/>
    <dbReference type="eggNOG" id="ENOG502SEM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1597811_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4L7"/>
    <dbReference type="OMA" id="FDATEWK"/>
    <dbReference type="OrthoDB" id="57792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="184" mass="20802" checksum="C2565F61111D97FC" modified="2008-11-25" version="1">MPESDERKEDEDVTVVNDDSFLAIGGRKGHVMEIIHGNVLQLFRSFRWKAIPRCTGRYTCRDHEQVSHLTPLQMLQHIQSASSADGSPAKLRFDATEWKSWMLKLPGKTDELWVVPLDSANQTGIITYVKTKEVQDHVPERIATDPADTLNSKCYVHTLNTVSGFRRKLAALGLRVNELSIEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4N7</accession>
    <name>B5Y4N7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgin-84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_43887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186042.1">
        <property type="nucleotide sequence ID" value="XM_002186006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4N7"/>
    <dbReference type="STRING" id="556484.B5Y4N7"/>
    <dbReference type="PaxDb" id="2850-Phatr43887"/>
    <dbReference type="GeneID" id="7204301"/>
    <dbReference type="KEGG" id="pti:PHATR_43887"/>
    <dbReference type="eggNOG" id="ENOG502QV1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369005_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4N7"/>
    <dbReference type="OrthoDB" id="248903at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09787">
        <property type="entry name" value="Golgin_A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
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            <begin position="134"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
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        </location>
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        <location>
            <begin position="318"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="624"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="158"/>
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            <begin position="245"/>
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        </location>
    </feature>
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            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
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            <end position="459"/>
        </location>
    </feature>
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            <end position="568"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="89773" checksum="3DC58EA5CC632A4D" modified="2008-11-25" version="1">MFRNRNVDSVLCRQKSTWAAEYCGLFWYIPAFGGLHSCGWQTAREFSFQCLQSIMSRWLQNVGSFLEKLDDQAEQIADGNIHLQSEEGEVFGQGKDAIESILVARGLSLSNEDEKEGEDDNLDDDVEYSVQKFSDTEQDVGNHEPESDLVEEGRILSDENSSASLRTSSVSEEVVEGVAAVLTDVGSGLGSTHSTVEVERNSGGDGVERNDSGDEGGAVVSENGAKVSIGDIPVTPAKETPVATMATSGHTQPETPFGTPAQTATKPTNSGAPTGPPKPPIPPKPATQKAQDSAEAKEALKQVRILRRHVLSLNQELEKAESEMQAQRDELERAADRMEKDRVRRKEEQEKEKVRHAEELRALKSQHDQILKDVKARSDQQVNDVRRQLKELENRRMQEGGDYNNELAEAIQREQDMMQRYSMLEDEKSTMLSQIATLQAQQESLGSRLESLSQSADSATQREREAEDRLDDALSTHARQIGQRQAREADLERTIAELGAALVSARTMATNGSSRHGKEADKSSQVTERVIDLEHEIEVLNGYLTHEQQCSNALRQELQDATRERAEEAAASSRRHVHNDRQIAELSQTVLSLKTELRDISSVKRKDSIIRDDVTSEHEELNQIKTLSEEVLRQRENLTRSNNEVSTLKSRLQAALERATLADALQDQLGNSSMLDLEEATGKTRKRRGAKSGVLLQGGSIRGALRLNPALRESTERLGKVLDGLDVFLVESGKFLRFNPLARLLFIVYLLLLHLWTFTLVFLHAHTFEAVHGDFGAGGTLANGPHALMQQPVNPETYEAEIDNIPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5J1</accession>
    <name>B5Y5J1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_18735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002186156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5J1"/>
    <dbReference type="STRING" id="556484.B5Y5J1"/>
    <dbReference type="PaxDb" id="2850-Phatr18735"/>
    <dbReference type="GeneID" id="7203903"/>
    <dbReference type="KEGG" id="pti:PHATR_18735"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="B5Y5J1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACI65662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48302" checksum="829DD0D4259B487B" modified="2008-11-25" version="1" fragment="single">MFNFGMFALEQFKGRLHEWPQYCSHIVQIPHLKDGYAALVSEIEREMSKNQGAASVAGQQPPVPKVLESGLAGDTLLPHPPGEAITSHRSQSAPVPSALELSSEVLNLSSPPRVAEFGPKLGRAVTDSPDSENDFDAPTDTVLDRVQFLVNNLAQSNVEQKAQDLKEMLDPKYFGWLGHFLVVKRISTQANFHSLYLSFLDNLGDYGKGLMEAIINSVYRNIGKLLRSSKITTSSSERGYLKNLGIWLGQITLARNRPILQIMLDAKELLLQGYETGKLIAVAPFLAKTLEGAKNSRIFRPPNPWLMGILGVFRSVYMVDGLKMNIKFEVEVLCKNLGIKLEEIPLRNGVLAKRIAPVKERNPDFNIKSASSGSKSSATGVVPSRSLVGSSEAQSLNLPIPSTVPSSEDKSGQDPQDTVIPNLASYVTVNASLPQLLQTQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5M2</accession>
    <name>B5Y5M2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_44186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186493.1">
        <property type="nucleotide sequence ID" value="XM_002186457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5M2"/>
    <dbReference type="PaxDb" id="2850-Phatr44186"/>
    <dbReference type="GeneID" id="7203916"/>
    <dbReference type="KEGG" id="pti:PHATR_44186"/>
    <dbReference type="HOGENOM" id="CLU_1121923_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5M2"/>
    <dbReference type="OrthoDB" id="10483839at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="170" mass="18601" checksum="D24EDDB2A7EAA8A1" modified="2008-11-25" version="1">MAPNGTDLEIVQKVPQLHLARLFVKDNVLYGAKVINRTLGEPKLVCGKILDAALQDVGIDKARARSTLHGLSDWVLDGMRIKKRVDSLSGLSDGELSAIEAIAKGLSTEKYDTSRMIWEKLAQEYIDRGCATEAALYQSREGVLTEIEHHADTSELANTSGGAMALFEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5W0</accession>
    <name>B5Y5W0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186257.1">
        <property type="nucleotide sequence ID" value="XM_002186221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5W0"/>
    <dbReference type="PaxDb" id="2850-Phatr33082"/>
    <dbReference type="GeneID" id="7204080"/>
    <dbReference type="KEGG" id="pti:PHATR_33082"/>
    <dbReference type="HOGENOM" id="CLU_527330_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5W0"/>
    <dbReference type="OrthoDB" id="39806at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="517" mass="57982" checksum="B955197DEE32E2A8" modified="2008-11-25" version="1">MNCQKLKGVTELRKGCSSESSLKAASRHFDLFLEEVISSGTIGGKEKQQLFPIRSINNSTDSNNIDNSERLDGDAQTQYSFKTIAAEKINDKLLNLFAGYLTRAEKLRGNKNETQDNFSDGNGISYNTAERYLSSIKNEILRRCLDLGLKRSFDDAQQTRIRQSMTRRFVERAVRNKTPLARSHVTAARNDFLVIAFLCIWDGSFPMADMLFYLLTLRYLAGRGQEVAMISRSRVSLGEPSEWADSGDKTFVVRLWRSKVSHEQDLSIVPHQSEMLLDWVFAFAYSAVMNTNPNDSLFPTFAEKVELRNLSAGNINDEEIGNETTQDSTLKAKVDSSKKVTKYFQALLERLIKTSEELVGPNEMARAAGLYQDDEDFSEEFDGSSCVGTTSVNNEPGIFNLTGEEETVGLDPPANAAYYYSGLLHKHGISAGLSTHSAKRSAVEMANESALLLTTWVCFRAGWLMKAVHTIFDYLSFNPKNDRQVSRVFSEWNTPSFRGEILGGRPPRLHPIRLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPA4</accession>
    <name>B7FPA4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_31768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176674.1">
        <property type="nucleotide sequence ID" value="XM_002176638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPA4"/>
    <dbReference type="FunCoup" id="B7FPA4">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPA4"/>
    <dbReference type="PaxDb" id="2850-Phatr31768"/>
    <dbReference type="GeneID" id="7196354"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31768"/>
    <dbReference type="eggNOG" id="KOG1071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_2_1"/>
    <dbReference type="InParanoid" id="B7FPA4"/>
    <dbReference type="OMA" id="YLHRCPR"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.20:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="5">
        <location>
            <begin position="69"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="30798" checksum="F4F60C9F2F44B828" modified="2009-02-10" version="1">MESLKDLRVQSGAPIVECKKALQAAGDDLDAAMDWLREHGAAKASTKVQGRETTEGLVSMKVSDDGKSAALVKIASETDFAGRSTKFVDLMLNVVDAIFQSSEDGNLDNDTVLQATLGGKVVKDFVDEAIVAIRENLSVTNAVKLRSEDGILVGYIHNRVDGSDAGTAASIVELSGKDVTVDILLTTGKKLAMHVVAARPQYLSPERVPGEVLKKEKEILLKQMEGSGKPPEIMNKIAEGKLRKFYESVCLTEQGHMIEEKSPKVGNVLKDLGITLRRYEYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPK0</accession>
    <name>B7FPK0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RZZ complex subunit KNTC1/ROD C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177224.1">
        <property type="nucleotide sequence ID" value="XM_002177188.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr42793"/>
    <dbReference type="GeneID" id="7196408"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42793"/>
    <dbReference type="eggNOG" id="ENOG502SCXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FPK0"/>
    <dbReference type="OrthoDB" id="47965at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2730" mass="299768" checksum="F119D9587CBDA5A6" modified="2009-02-10" version="1">MFRARHGSLPSLPGGQWDGSPRNGIGSPTRIQKMVARGDGGCATDECARFFDADEIPLSTTLSEIGSRISRWWTRVAKSDIPAFLHGTALLLSSLSFLYPFSSCITRYSNIIPTLTMTTTSHRPWLSSVRLVDWEWPVPEESTIAHGLCSTSESTDCTVGRYALARGSSVYGFVSQQQQPHTTTSTRSTNTTTTSTSSTNTTTDDTTTVPFLTPAWQVSLGSDHAVVTQVVTNTTGTIVAVAIAGGTVAVLRALDGAVLVTRSLPTRSDVRLSFGVHANGHDTLCIEILTRDRDPTSNTTTHGGQLVVVSHMDGSTLPTLALDGRMDDADVTTTTTSLAHAVARWRIHTLTLPDDLRSVREYRTRGDPETPRFVGMYAHGRALGVYRTVLVPTTAHEAAELVPETPGAVDEHPHRILDAEQGLSVASRSFGKPGRDQDSDPFFFVGSYSGTEASRASGVFWWDPDSVRVVCHYNMRHGGPVPFHSKASVPNVLDLTPIQAYSDDTLALAVAYRTSTGACLQVLQVLLDETMGLTVLANPHVVFTIPLETRVPLAVLSLSPTPPNSHPQPFGFFVQTALETSHRGTGRYRFFLPDATAARVGHVCQLLQRGDLDAAEAVVGQYNLAQLDHDNGHVSFHPSQIALKRLASLLDHHPWVETDVAQRCLHNLARGARTGNRFGVRSLLQAVDLVLECPVRDALLAMNTVIDTVVQTTFPESTRQLHTALVAKQRELQDRLDTVRYLETVELPSSRSVAIRSARTPSHLFATLVREGCYGMAEALWYSHLRSSLSDEVLVASVLNITHEVDPSAYIPLLRDVVLPSLAINHELLPTLRAWACRTADALDHHWSEEKGLAAAIQLLEVVDRGTKDLQLRIHQSFATYSPFVTGLNESTGRKLTLTRRSPRARGGVGSEEVSHDSQSMTSGTLSSRHTSGAEEPSSTTAPTPTTLPESSVQRTAPTVLKLGHLEIGAVKRRQPNTLLAMVHGDDDDDCIYEGQRTARGLGFTRDAATLRTFGPNGGETFCAQQLVQLCSRGSESHDVRAKNLAEQVKPFCSRFGVDYDTIVLQCSESLCRGKHIGEDQIREATSIACCCESVSVKCHGILAALRAALLCGCSADWLTHISKNAVAWASADSKLQSELIEASRLLLIDSIVRKYCGSGAKDLFRVDNPRHAVRLLDFVTKHLDRESVVDDISSLCDAFTHLSPKHAFGSLIQRALLQDKVDLAAAVLAQLWDRNPSLAESTLASTVSFAEEILHESSAFDRNPVQVLNHETELVKQNARRMAIGISALIQSVMEHTVRLNSENAAEIDCWTVLGSLPILKASVERICSLQSESGVYTCLDHWTCTSQIVSIASDLVLAATEDHLECEEAVLRPLIKKARRGVSLLESSSTVWGKELWSVAARQVLVRSIRENPKEKTLILLQTADLDAPFHSPISTYTQLTTVVELCRRGQKSVPVEGMKLVTVADSLLRNQVLPMCGAQLLPVVVSLRCFLDTAIHVFLQADEGVGEQIEQMQCDLKSEILRRGVDSSIKHSRPLLAQLPSPKFHPSWYVGDGLLLPPQEALDVSMDFCLQGVRNDCFLSDRALKIHRFLGERGAHFLSLRILCWSSVVQSCYRGPPLASGIEATAENNCYCAVRDTMNFLAERSLGGSSSGITSGSVDSELAVTFLLSLPMKSAFNVYKSALPSGIKTRAFDRVLSLANVGRVACTEGTPVDFQAFSAVGWAKQTAFARQCERLALKASWWKILEGFGIEFDPQRFDVGETHIAGTGTASSDLARCDPTYTISILEALLWKTSKILESPIVLRLCGRFAASFDLPRVLVLQKHVEYLLSAQITKAKSGHCVGIDRDPRSDLHQCRRIAQASLLEIEPPVRRCEIVRRCILALQDSSTSETDYERYSMLFSLYHDSLTFVLDNDTAVQGLSLNQLEDELESVDRRRDALAILSDFFQGPRLIKRPGLSNFFPPLRSLSLNAKPLPSLNKCSMFGTSTVSGEHFDPLHCLDKLLSESQENVTALAPLCLPLGLPQGYIHARSLVVRFKAAANRESAYPSLENDVVPVLNRLRSHTDKYTLADWCASYFTNNDTDNENLACIDLALQSAIEASNEAERRMQHSNGDDKEIMMLEQFALEKLRTISLKRDALTDRLKVKAILTTCNGSHRDSVSRLSCSLAQLLDAETKSNPNMMPEDIVDFLLRSGSRLTALASLDDKVACTTEQFRQFSLKVKDACSSIAERYSHIQPDEHCKQLARRWLLFGEKDHSLIGFQSVATMSGARSTDVSNEKAKDDDESEFIMDIADLQAKDDWDDGIALPKQHSLNQFTSEEERSSLLPISMRELSEVGSHRASLRIAFVLVVADEYKSLGARAVEIVDENAGSGALNLQKTKAKGRLGLLSRIETKRESRNESSIIQLSRELLRVVFGASDSAITLFGANSSFDGGVALNEQSTTPKSITFAMRHRALRAAAILCPQEILERVINESVMSEFASKSALAKECLLKDCAFGSYVAKEIEEMGLSLPHSDLRQLSTMHFLSYARSLWRHHRGGEMKGYKGRLLLLLLEMCLKAESTDNAFVTMLLNEMNRLQLPRTLLHALELTSNYNGAGDELPFVQDPSFLAALSSLIGAMSSELQPKECTLIPDAYHFEEVVESLSRLGCIVRLVSWTTSGNDSLTHFTNLAASASSQACFEPISKDIRRIVESTSHQMNAKNLGVSLQVGTRFAGWIGTSHLLSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPQ5</accession>
    <name>B7FPQ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177255.1">
        <property type="nucleotide sequence ID" value="XM_002177219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPQ5"/>
    <dbReference type="STRING" id="556484.B7FPQ5"/>
    <dbReference type="PaxDb" id="2850-Phatr42834"/>
    <dbReference type="GeneID" id="7196492"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42834"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016642_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPQ5"/>
    <dbReference type="OMA" id="AMNDFHE"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="482"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="639" mass="70907" checksum="2857C19E34F0176B" modified="2009-02-10" version="1">MDDERSNDEDNGGEVSDQAAAAAPPDILPVEEEDHERNPPPPVVPVHAEAVSILQLHRAPPNANFHGSATSSSSCAVSASNQSLLRQQAHSPVSNATHGLEVSARSFQGGYRRSYEAPFQQLAFSDTSPELDMEDPNASEQSSGWSDVAHSQDHGNGGVPPSPRSLHAGALLNGNFYTFGGYDGNQRVNTFHAFSFAEKRWSPVFPSANSSPPPTPRDRHVAVAFGNAFYVHGGFDGTSRVADFWAFDFSTMSWREIVALQGRHPSPRHSHAAVVHGHSMYIFGGYDGSYKSDLHEFDFTTSRWNAVPAVGRRPRARYRATCVVHKNSMILYGGHDGTRHLSDTHVFDIDTKTWAILLTEGAPPVPRDSHVSVIHMNSMYVFGGSTGSAMNDLHELQLPSSSSMSAKWRSINASHAEQPRHRFCHVAVVHSDAMFVFGGYDGSDRLNDFIRFDFTVYDLSFEVPQSTLIADFRSMINDVTLSDVSFIVEGRDSPIYAHKLMLVRCPYFESLFLGSMRESRQATIYIEQVSYPIFLATLEYLYTDHVSISLKNAMELFEAADLFCIPRLKTMCEKRMLQSITVENAAGIFLAADMHSASALRQKVKKFILSNFEEVSKSSCFEEMGRSNIELVFELLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPZ9</accession>
    <name>B7FPZ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177303.1">
        <property type="nucleotide sequence ID" value="XM_002177267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPZ9"/>
    <dbReference type="STRING" id="556484.B7FPZ9"/>
    <dbReference type="PaxDb" id="2850-Phatr42910"/>
    <dbReference type="GeneID" id="7196540"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42910"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585908_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPZ9"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="7">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="387"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56434" checksum="34CD3771B6BB0420" modified="2009-02-10" version="1">MRQVRYRLSVIPWTMFLARSWKPYMVQAWTTFDRHPGIHSFPGNLWLHGGTNRRARRYLTMRVGDADRRRDGSPGSLEPMANLYREWSLEQDQLLWENRQESTASIASLLGRGLRGVEARLSKLKDVRSPAYERLFADKCKKHKTCLLEDSQAKIPASEVLRRVQYDHLLSPSDFYILHFDRVDDAIIESRMDAPNDSISGTATTLVDALPEHRIIAIKFREQVVWDREKRLDLVFGSGGIEKVMKEYEVWKRQRDDAQEWNRQQQAEVSERIRRCLGPESFVALKALSSSLQIKIADPKVSIKIEVERYVHKALNLFKTARDKPSTSLDPALIPSSDYKALDMLSELVALLPDSELRPMILTEIAMELTAAEGKKEKVYTARELPELNEDDLTETFVRGSGPGGQKTNKTSNKVALLHGPTQLRVECQDTRSLQQNRKIARKRLRAKLDEFLNGNQSKSNLEKQKAASKKSKTKARNRARQRKREEADNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ06</accession>
    <name>B7FQ06_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_24775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176801.1">
        <property type="nucleotide sequence ID" value="XM_002176765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ06"/>
    <dbReference type="STRING" id="556484.B7FQ06"/>
    <dbReference type="PaxDb" id="2850-Phatr24775"/>
    <dbReference type="GeneID" id="7196544"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24775"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQ06"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000094">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="711" mass="80828" checksum="814D048C43F3707F" modified="2009-02-10" version="1">MWKLHQEEAGGIIGDEMGLGKTVQASSFIGVLAASRKLKSVLIISPATMLQHWLNELAVWAPGLRRILIHQSGEDLETLPSHSFCGTGYVVLTTYENVRRNTDIYTEHAWSYVVLDEAQKIRNPDADITLACKRIRTPHRLAMSGTPIQNDLKELWSLFDFVFPGRLGTLPAFEQEFADTIKRGGYSNASPMQVQLAYRCAMVLRDLINPYLLRRQKKDVIEVSRMPGKTEHVLFCRLSQRQRALYEAFLLSDEVTKVVKGSKQLFAAVTMLRKICNHPDLACDPDEASFESFVRNGYVNQGDLDEDLSDLDSDIGEEKSLVERSGKLEVLSKILPLWKKQGHRVLIFCQWRKMLDIIERLIMLKEWKFGRLDGNTNVASRQRLVDQFNSDESYFGMLCTTRTGGVGLNLTGANRIILYDPDWNPQTDAQARERAWRFGQEREVTVYRLITAGTIEEKIYQRQIFKTALSNKVLQDPRQRRLFSQKDLRDLFTLKADAGSVRSGGEGLTETGAITRHGGVVNIDEDPTDEPSLDNDEALKTVMRSRGLAGVFDHNFVEIDSTKKSRTLREMEEEAKRVAKEAIDALQQSVATKQRFVPTWTGSEETQQRRFGTPKMHMVDSKDSLSSRTLLASIRQRDNAVHSGGNHLPPSDESQEYAKLLAKIKDYVYRYRPTTDDLLKEFESVSNTDVAIFRRLLKSVANVDSGRWLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ75</accession>
    <name>B7FQ75_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_32099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176831.1">
        <property type="nucleotide sequence ID" value="XM_002176795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ75"/>
    <dbReference type="PaxDb" id="2850-Phatr32099"/>
    <dbReference type="GeneID" id="7196795"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32099"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726599_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ75"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="37278" checksum="D41442E637445FC8" modified="2009-02-10" version="1">MTSKIKGEPEKDPYDVLGIKFNASDADITRAYRKLALKFHPDKQRSTLSSAQQEKNAQDFQDIQIARAYLLDPEHAESRRNYDSKRASISARQAADAAREKGMSERRKRMRDELRQGEEQASKQPTLRPKATSRSKSENEMVDKLRKQGAEMREEYGDRAATEAAKEHARNSSQAKEVRRKQKESREDRQLRLKWSRRKIKISPSEHSLATLLSKYGMVESVEMLGSKGNSALVTFAETASCGPVVDAFAESEEMRATFVGRRRDREENSKSADDDPLEATLPRSRDTEDVDDWKTRQGAERELRRKQSHDARKPHGVEAKSRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ77</accession>
    <name>B7FQ77_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176832.1">
        <property type="nucleotide sequence ID" value="XM_002176796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ77"/>
    <dbReference type="PaxDb" id="2850-Phatr42977"/>
    <dbReference type="GeneID" id="7196796"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42977"/>
    <dbReference type="eggNOG" id="ENOG502SXRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1285492_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ77"/>
    <dbReference type="OrthoDB" id="46929at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852544" evidence="3">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="22612" checksum="52254BC76458F5D4" modified="2009-02-10" version="1">MGVHMIVRSMAMLLAYFCLGVTTAFAPRHFTLTNNVRSVHAHSTSAMNLAVDPSLLDGSALSLLTPSFMTSFASSALIATIDSDIASIPVNEFAPVFAGGMAVMFGGVLSAIITGAILEKRDLYATVVAASYAQGGDGDEEFWKSLSDEEKLKAKDMVQKLKAAGNEGAAMELEQMMTNEGTSNTPSATTASSGSETVKKGVDNKKADMFSDYGE</sequence>
</entry>
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    <name>B7FQI1_PHATC</name>
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        <lineage>
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            <taxon>Sar</taxon>
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            <taxon>Bacillariophyta</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176876.1">
        <property type="nucleotide sequence ID" value="XM_002176840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQI1"/>
    <dbReference type="PaxDb" id="2850-Phatr43063"/>
    <dbReference type="GeneID" id="7196706"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43063"/>
    <dbReference type="eggNOG" id="ENOG502SFGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1317687_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQI1"/>
    <dbReference type="OrthoDB" id="45605at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021434">
        <property type="entry name" value="DUF3082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11282">
        <property type="entry name" value="DUF3082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852525" evidence="2">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="28888" checksum="C3BEEE4C850542F3" modified="2009-02-10" version="1">MGIKRLLLFLSVSFLTRPGWSLAPAVRICYALSRAPYARQTTSIHMAIDSNKEIGTEIKMNQEISGQSRMSAEIVSGGASQEKALTGTVNERLMQELEAEKDKEKFGARSKLGKKLGLAAFRSQKTDAEREAAIAEARNLNGVNPLVTLAGSLVALGIAAGLWAATNSLGAFFTLNPVVSEFYFVERSAAVFRNVAMGLISLASGFFGVSGLGIFLLGMRVAYGVVTGELDPTPLKKPKSEGLEMPNVWALMTTTKPNRRVKKKDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQN5</accession>
    <name>B7FQN5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176900.1">
        <property type="nucleotide sequence ID" value="XM_002176864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQN5"/>
    <dbReference type="STRING" id="556484.B7FQN5"/>
    <dbReference type="PaxDb" id="2850-Phatr43112"/>
    <dbReference type="GeneID" id="7196886"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43112"/>
    <dbReference type="eggNOG" id="ENOG502SJ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388065_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQN5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="708" mass="81251" checksum="7113C4E128C6CB56" modified="2009-02-10" version="1">MMCSFGIASASIPKPALSPWTTTSKKFLTQPAPWNSGCVSTKFPSKLHRPFIQFQRYHIAACYKQHICRQRLTCFQRSLIFTNCGGFKYWHLPGFLDDTSIEEKEDWLQNLLQDKEDLSDTEAYLVVLRSLATSTQPDAPMKAERWLRRLEARSVSNPDAPQPTTECYQRVIEAWGQATNEDPNLLITRTQRWLMKHLRNDNIDLRPDTACFNSFLDLCSKGRALKRAKATDGNLVRDHALKAEQTLRLMIFKRRKEGEDSSMAPNVDSFNFAIRAWTRCRRSPDIADRSISVLHLLENYEKTLDSSVRPNVKSYAMVMDSIAVVARLKVKRCQSMPKTVENPSTNGLNEINLLQEVVSYMRNQASLGKHHLAPNGVIFNTLISCWSSLAKIHSHAPNESEKILQSMIRMKDMGENHTAPDATSYLMVMRTWLNSQQSIRAERISWWLSKQWKDYDFEGDEGLRPNTTTYNLVMRAWAEKGEPKRTEALLAELIGHSEKDRAGNLFPTSESYTLVIRAWLVLANRGDKSGFETAAYWFYCLEARERDESGLVAPSEFYTLLLAAGRKCASQHPDILETAVKIFDLLRESHHRVDCLHYSSLLQIGLLALSRAEQNKVRQAFIDEIFKNCCEDGLVSSHFLQALANGPVYYDGWTVEESQRTLKRIIPCWPLPYTWTRNIRQKGFFPQRQGLRRSNFVCSPHGKDPYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQZ1</accession>
    <name>B7FQZ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_17914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176951.1">
        <property type="nucleotide sequence ID" value="XM_002176915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQZ1"/>
    <dbReference type="STRING" id="556484.B7FQZ1"/>
    <dbReference type="PaxDb" id="2850-Phatr17914"/>
    <dbReference type="GeneID" id="7196939"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17914"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="InParanoid" id="B7FQZ1"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34269" checksum="925EFC6D5F5DD058" modified="2009-02-10" version="1">MPSQSLSPLIAGFTGGVVSTTLLLPLDVIKVRLQVNESPASPVGSDQKHGRKRRLGATRVMQGIVKHEGFRGLWVGWTPAVIGSAVSWGGYFFFYESFKKQLSASDVLSSLDNFALACTAGGVMVLMTNPIWLIKIRMQLQMKRASELLNIKPYRNIGDAVATIVREEGPLALYKGVGPALLLTSHGGVQFVVYEYLKKHFRFQRINREETGRATQGITKRLQNTVTYPLQTIKARMQQRSDALEFTADGEVRAVRRDYRGLFSTIKRVFRQEGFVGFFKGCIPNAIRVAPGAAITFVVYEALMDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR07</accession>
    <name>B7FR07_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176962.1">
        <property type="nucleotide sequence ID" value="XM_002176926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR07"/>
    <dbReference type="PaxDb" id="2850-Phatr43215"/>
    <dbReference type="GeneID" id="7196579"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43215"/>
    <dbReference type="HOGENOM" id="CLU_1356991_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR07"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="22190" checksum="7361BA6A8DE2D3C7" modified="2009-02-10" version="1">MKRGRDQVHAPTTEELNAAISSILRNNESSSVKEICDLITKNHKGWTLPERRVAKFVKRQKQESKAQTDDDASRVSTPSLLRARGVLGSAVKGTSRSLRKVLYMGTKKKDHDDGTEHSESTSSPPVEVVSSQNLLPPLSFDDMEPARMLDFATPEKTETRPLDAEAAPDSAVDVPLPTVYHDDNKGKKDSGFCQPCEGCTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR12</accession>
    <name>B7FR12_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176965.1">
        <property type="nucleotide sequence ID" value="XM_002176929.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr43220"/>
    <dbReference type="GeneID" id="7196946"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43220"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FR12"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="3">
        <location>
            <begin position="1939"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="2704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2704" mass="300932" checksum="60F924E9AA4A2AF9" modified="2009-02-10" version="1" fragment="single">MEEVLGEYILNMSRDNLKIAALKGQIKLEKVQLDGDLIASHVLGAVGLSGFGVLSCAAETIQIHVPWNALETEPTTLEIKGVHLVCVPLTAATAHQRYGGTGRGSGSSNSNTTSSSSTALDDPRCTLRTRAKRLVLARLERNFWNGQIPDEGPPMKRITRAVREIERDWKKSSRRRRKRQSSANRQAQSGNANSADAEEALDSLVHDCMSETTDSSFFSDDDDRAPADSFSVDDLPEVPRDWKVKLREKVFRNVEATLQDVHIRCEVSAHGLDTVYQQHSRPATAEPSFVQKQPEERAFALGFTLENLVVRTANGQWEVGSHEISEADGSAMSSSKGNLGPNMYAVKNNKIGFFNKISLYWDDEPPLLLAETDMLRGNLRKISPEQVQSRISSAMKALFRQPEPGKKIRQSLSEPVPLDMDESKPHQYICESLEVEMRGRTSDRSLPGPISCSFDVLPFEFTFNVRPHQFLQYQRLKMAIKSQQRFDTMLRQRPTVSPLQNPKAWWKYSIACVTSRPNSRPWEDVLRIIKSRPRYIELVIKKNVSKSDNNAYHAGLSMPESSELLALEDLLPIESLTAFHLIALRSAYRLQKRDKGTSKLPPISDPRQPTDQIPRDTRRKMGHFRMLRGSSRSKTFHRLTDSEFEAPLMYGQPRELEVPKTPRMETSVARRPEDCLATSQTVSLFEAMTMRLGKKAWFVDCKLHDAIVNVVLLNTEGDIPVATCVTRASGAARSFGLGKRDLLFDVSQFDVFHGGSEILFVRAAEGNAISEEHELIESGGSPRRGTSLRLWRKRGAETGAPDLETPSRYLELPPEGTVCRIAAAKVHGKHFLSMSAHPATLVWTTTLLSDLSEFSPSESLELQSNLSQHIRNAATPLARKAQLALLSPASMALHINISAPKVWLPMISNDSQGALFLDSGLLKFSSVKGVGESEVHLQAQVSDIRVKFLRGRTLPSLPENAQVHLLSHLMETGVGRSETSVVQPFSITLNTISSMIQQDDFGTSWLTDGFEVGSPVRRVMVEIGPVRLNLVDAEVLARAFGRWYSKGIRRVRARVSIGSVEQSTSHGSHRTVESAPEARFPLDSIHPVSVPVIMSLRIKKLEIALEGHSKTQLLVDDDRSLAPLDSFHKSSPSTRAYVVEVIGIDIKRLRLSQQTKTSFSVSDAGIVRLADGSSYNPMSVRRESLGGGAVLTASHFHDGITHLDEVEVDIASTVLRVTPTTLKDCAKAIKKIAEVTQLLTREMERKVHEEGRQARRRDRSGRNDATFQTGVSLERAASPTFSEAMTVHTALDPPALRSSIDSSILFRVTLKESTILAGCPTEATRKTKPRQNKSTSFAVIQVLSNTLIMFQSIENPDTTGTKTLHVSIDNLSSLVNTEFERVSPSQVPPMIGPTGVEFRIVYSTECLGCIVSQEISFDCDVMKCCLTPNDLMIMLSIFSKMFDRLRVVDLSHGVNTELQEQRNGPRARPFSSVVRYQRKGTGIATRVRLDVQTFSFVLLRAYKSHSGAPEFLDINLQEIKGHLEGCLSALSGDCCAEVSVKFFNSEAADWEHAIEPFLFRLTIDQMPNELLLRLNTEQQIQLNLTGKLFRDFSEMKFDIRRDTLSAGYSNGEVLSPSVLSTVGLRRASEARSVNLKNLCGFDVCVLPTSSALNIESGLVPAGSESILNGLGSITKEDIAGELSLSLIVPESAFSKIGPRQPISELRVGPSVSAHKRLCILKPFPASVDYPGYVESNGGSKSSDSALSEASASPRPHYGAEPVVELCMHIQRLRSSVADVFSLNKGHDLLSSSIWSPENSLNIDVTTFRPKDESEDATGGNLAPLFPDCNSQKAVKSNWLRPYLKNDTPEWTDTTCTLRMARDRVMLPDRNWIWVDDWNVDISGALCESTDADGWEYQEDFVGFGRFSRHYQRGDSCRRRRWTRTRIERPLRLKDPNQIFKIVWETSEDDNGNYSITVRSHVRLKNSTAGPLGLFVYSPSWDSDTFVGIAQPGEWQCVPVLFATAVYLRLARVRRSHETVSLEDTTMTGRMMILPSSYTASRFVRTFMHLEDVSRTTLHFMLEIKCERGMVDIIVEPVVRIVNLLPCQLECQLGEVITSGDRRPHDSRPAVGGDEIKIAKTETLSIRTGEEKACTAVSPWLNPHISLRLPGYRWSSWFRIVNRKANSTTWRPSALEEDCQFLSKKEGDFPDEFKWVVKFERMGQSGDPLLVVLSIECAHTPILRVYAQYLVVDKTGFGCRFTDAFVDLLGSAPNAEVSRRSHILPHDANNPDMKGDMTTPGHQWSIGMSGMTMYFSRREKLALAIETGAGNGKRFRKSQTVRSKWVSPMDVSNVMPKTAFSVDELNGIKRFELAINVTICPGAFGRTKLISLLPRYQIVNLLHRELVFAQDGCLGAETLIPSQSSVPFHWEQGILEPKVRLGAPSIQERDSRAFGKCWTNGKLRLDRVGITAMRLPTDNTLSRSPMVIQAEVRLATKDQSSAVVVVIWSANEKSNPLYLLRNTSLYTILCRQPLQKDEEEKVGSNGHPFMVDGCSPSALVHDSFECGAEIGPMIRNFLGVEKIQDFVWVLSPGDVVCFGFDDPEKPQILEWTYVGRGLPSFHEECRKAQMEVNAMGSSSILAVAGGGRIVCQIGAEHSTKVIEFMTYGNSSVLENLDECLNLSTLLNDDLKSPINISSDITQRESPIQIVDEDDAVAFSIRVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR61</accession>
    <name>B7FR61_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_9323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177525.1">
        <property type="nucleotide sequence ID" value="XM_002177489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR61"/>
    <dbReference type="STRING" id="556484.B7FR61"/>
    <dbReference type="PaxDb" id="2850-Phatr9323"/>
    <dbReference type="GeneID" id="7196605"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9323"/>
    <dbReference type="eggNOG" id="KOG1071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693544_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR61"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000051">
        <property type="entry name" value="RNA-binding transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="65" mass="6975" checksum="F6606DDD159DCC32" modified="2009-02-10" version="1" fragment="single">DFNVGDTVTAKVKSIASYGAFMDFGAQTDGLLHISQLSVGYIKDVSEILKPGQEVEVRITNISAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR85</accession>
    <name>B7FR85_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176997.1">
        <property type="nucleotide sequence ID" value="XM_002176961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR85"/>
    <dbReference type="PaxDb" id="2850-Phatr42422"/>
    <dbReference type="GeneID" id="7196634"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42422"/>
    <dbReference type="HOGENOM" id="CLU_845849_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR85"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="35514" checksum="3CEEE2B2205A0F17" modified="2009-02-10" version="1">MLGACSSRPAAESVPAMISPSNRVLVSKDGRKIGYAISPAKISEDTTKAIVWFYPLSGCSQIVDKASPSLSKYQASVISVDRPSVGDTDALAVENNPIERIQGHADDVVAVLHQEGIRSVIKGLTLVAPFVSTSCKHSWKIARLGNWVPSLVLTCATKTIAFGEPLFLSMFLSESALKKLVSEEEQALFGWNDSDFKDIVDTLPVVGKVTANAKVTEAQLGANSMWQQVCDDFAVESGCGLVVEDGEETTKSPNQQGTVPSFPIVIHACRKDTIAPCAAVEWLARRCYGNSTIIIHDEIHSHEVMTFLGGPPRNPGLLHAIARDWELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRC4</accession>
    <name>B7FRC4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_31442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176522.1">
        <property type="nucleotide sequence ID" value="XM_002176486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRC4"/>
    <dbReference type="STRING" id="556484.B7FRC4"/>
    <dbReference type="PaxDb" id="2850-Phatr31442"/>
    <dbReference type="GeneID" id="7196632"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31442"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_864536_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRC4"/>
    <dbReference type="OMA" id="ENEYMNN"/>
    <dbReference type="OrthoDB" id="196537at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="322" mass="35097" checksum="5D2A7D8EE3D140DB" modified="2009-02-10" version="1">MGILWSSFASGAHAASSMTAAKPTILGSNAVNNFAGAFPTLRVVSTALLLVSSFGGVLLQLALRQLQYGAAWYMTQLALYPVLTKSATAALIGYIGDYMAQWLEYKLEQNHQKGVIGGGSCDGTQQHHKISLNSSNSRVSARSNLSIHGTYDLRRGLSIMTDGLLISGPLMHFGYAFFEHLVPVSTSPLAAMLHVIADSILLDSIFVATTFLVTGLFEGYRWQHLSSHLRSDYSSTLKASWGTSLALMPLEFVCFRYLPVSLRVLAVNFIDVVWDAVISFMVHRKRKSKQVTTESLGTATNDAVLCDEPTLRRPKIEPAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRJ4</accession>
    <name>B7FRJ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176556.1">
        <property type="nucleotide sequence ID" value="XM_002176520.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr42513"/>
    <dbReference type="GeneID" id="7196063"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42513"/>
    <dbReference type="eggNOG" id="ENOG502SI2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255759_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRJ4"/>
    <dbReference type="OrthoDB" id="48031at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1379" mass="153523" checksum="9F04FDBC1FD325C8" modified="2009-02-10" version="1">MSTNRSIRDGSPNVANDHPGDTERRKSPISTPAASPCHDETDDAPVATLDTAPEFDGGTNESWMSPVLETPRARAYSSEERGAISASVGRPPLIVTTLADTDNTSVTEGTAPVSPATSTIPVHRRVDSSDANSLPSLSGPIQPAHPFFSPSFFEESDASDGSIVFQPPTPQRDTSNPDSLRFTGPQHVRRDSRGRDGRDRFPSFDSLGSSGSIRIVPPSNSSQIMRGKEKFSASSNSLPANPAPVIPSLPTIGQLPYHERRKLMAQRAKDQQQQLQLQQQQLQLQQHRPHIPPNLAPMPLPAPTLQHLPHQQQHQNLPQITPHTKEVASPYGQNVSFPPHQPQHPLPQAHPHHYIQNLPSGYAPHAGIPLRASHGPPPPPLYAYPVPQVPLGPYPPPPLQQYYGHLPPPPSQQQQLQSLWTRNNPLQTADKVASDPRQQQHLYRTSGNHHQIPLPPRGGSHSRNNSSTIGLSSNMSSSDGDVERKPSARVRPEIAPAQPPLPPPPPPPGLPPNYAHMRTDSSGSLSSLGSFDRPAKIEPRKASFLEKLNPWSPKVPNVNDYHRKNQQFLRRASVERGKLWSTSPQTPAGRRKPSVSTEGPPPTRGSHKRLNSIDGDDWEERPESLDTVPYGSKQNSADPSDQLTVSSDVNSSEDNDVDSLDSPQFYGHGSRRGYDGGAEPNERSNLLPPPGLNTSEYYDKSNASESRAGLSSESSQRRQSRRTNWPNEFQSASTERRGNTTGAKEMEYLTEKERRKLNRKKKKKKKKHERHSRKARVQSGSSEEESSSSVSASSASSHEYQRWMKKRARMLEKERSRLIKQWRAEAFAEERSTQQHSRWYRRFSRYQKEQFGEWVSQLFRFFIWLESFVANLPLTIGAIALAVANLGVDWFKFAEENMDSCEPVHFHSSQCTFPEFPGCFYCDTSARMYKVALNFHFACSIIAGVIASTFIAKLILARRVVFDELSSPTTATPAGLLCMTLNVVFAGRGLIGQVVVSLAGFIHLCLAIWFIYMALAYRIMPEPSWFPNTVSIGLSAVKIWLYYPMAGHFLMAISLSLNFFFFPISLIRVAMNRKISATVGWMQMSAPNISLYAMTLMAQPSFKEEHPDINRFQVVHRMVYLPCMHFFFGLCIVGMLASVHSLLVRWTEFRKIPFSPAHAAFCVPTLSHANAIQAYRAAVNSFSKVPVGSPFRSFLYVYWVFVLIAGTFLTLWIATKFMWSLPGWTHIDTAGEMEPPAPYETAMTSSNLITTGESLVQPFISPAILQANETGALVVSRDQYGAQVYRRTRMVTALGFEPIMNQLQMDVERELLLDWVGKNPPRRRHRTLSVPGIDFTYGATGAFGAGNAGVYGMDEGTGSPWFSRPRANTSSPNVSHRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRK5</accession>
    <name>B7FRK5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_17228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177058.1">
        <property type="nucleotide sequence ID" value="XM_002177022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRK5"/>
    <dbReference type="STRING" id="556484.B7FRK5"/>
    <dbReference type="PaxDb" id="2850-Phatr17228"/>
    <dbReference type="GeneID" id="7196693"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17228"/>
    <dbReference type="eggNOG" id="ENOG502QSF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351788_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRK5"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09859">
        <property type="entry name" value="PIN_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000003">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646:SF2">
        <property type="entry name" value="5'-3' EXONUCLEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="FLAP ENDONUCLEASE XNI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' exonuclease" evidence="6">
        <location>
            <begin position="59"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="389" mass="43300" checksum="F10F8DAC8A210614" modified="2009-02-10" version="1">MAGGGNRMAKLILDHRSVKQGIKRLKRKVLTKESGTLVKSVSTVVRPVTDSKPQEKTSDPLILVDASAYIFRAYYSMPPIHRSDGMPTGAVMGFCSMIMRLILNRIVEGERPRLVLVFDAKGKTFRHSLYPEYKGNRPDAPVDLVPQFALVREAAKAYGIPQIEAATFEADDVIATLATMAIEEGIDTNILSGDKDLWQLITDREEIPSVHMIDPMTMGRITYDEVVEKWGCGPRLLGDILALAGDSADNVPGVPGIGPKIAALLIEEFGSLEKLLANVDTVKQRARREKLKANEQQARLSRVLVDLRRDVPMDRMTFPQGIAKVSDLQMAEFDSNRILAFYDAMGFRDLKRRFENRLNQSTTKRGNAKSSRPPKTTIPTPDDYADVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRP1</accession>
    <name>B7FRP1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_42548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177081.1">
        <property type="nucleotide sequence ID" value="XM_002177045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRP1"/>
    <dbReference type="STRING" id="556484.B7FRP1"/>
    <dbReference type="PaxDb" id="2850-Phatr42548"/>
    <dbReference type="GeneID" id="7196254"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42548"/>
    <dbReference type="eggNOG" id="ENOG502QR3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802839_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRP1"/>
    <dbReference type="OMA" id="CCKPRTI"/>
    <dbReference type="OrthoDB" id="784548at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854931" evidence="5">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="37820" checksum="7E84F6F71B57A636" modified="2009-02-10" version="1">MSTVRLVSLLLVLSTANSFLARLSSTRNRNEVAVACRSEPETSNYWGDDTDDQDTLQPSLTPLSSFAASPALFELDPASDQARDIVMNDLKLSGAQHEQLVSLCQAVVDWNDRINLVSRKDCTVATVFGRHVLPSIACCAFSEDQNPLNTAKTLVDVGTGGGFPGLPLAIAYPDVQFVLLDSVGKKLTAAQDMANALGLDHVRTHHGRAEDLRDEVFDVATGRSVSAIPQFCAWMQHLVKPTGHLLYWIGGDVDASILEQTVSDTPIESLVPDMESDKRILILPQLAVKRIAKASGISVQPSPTNRSQRKRPSSQRKTTAKGSWSRRNSEEPKQRGYEGFKRYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS21</accession>
    <name>B7FS21_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_56626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177903.1">
        <property type="nucleotide sequence ID" value="XM_002177867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS21"/>
    <dbReference type="STRING" id="556484.B7FS21"/>
    <dbReference type="PaxDb" id="2850-Phatr25204"/>
    <dbReference type="GeneID" id="7197412"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56626"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="InParanoid" id="B7FS21"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="133"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="608" mass="63795" checksum="6D208965132A874A" modified="2009-02-10" version="1">MVSNALAVGGNNPTAGAPKKACLKVACVGGGQLGRMMALEAPRLNIQMSFLDALGTASPAAQVVPHSRIVQGSLQDAAKINQLVQETVDIDVLTVEIEHINVQALAALEAQGVNVQPSSRVLGIIQDKFVQKSHFEAHGDIPLPPYAATYSVGQIQKAADTLGLPLMLKSRKGGYDGRGNAVLKTNEIAAIEEALTSLGVQDTSAEDLDVYAEGWVDFSMEIAVMVVRSSDGTTTASYPAVNAIQQDSVCRVVLAPARNVSLSTRHVCEALAARAIDSLGAGASGMFGVELFLTKDGKVLVNEIAPRPHNTGHYTQDACAVSQFENHLRGVSGLPLGSTDMVVEAAAMVNVLGAHSNSMEETIRSSDAALSMKKASVHWYGKESCRKGRKMGHINVTANSHSELDDDLAALLAIEGVPVSLLPGGSLKSTPLVGIIMGSQSDLPTMQAAADICKTFSIPYEVDIVSAHRTPEKLMSYSRNAAGRGLRVIIAGAGGAAHLPGMVASMTSLPVIGVPVKTSTLSGVDSLYSIVQMPRGVPVATVAIGNAMNAGLLAVRILSTSRVELRDKMSAYQREMNDTVDGMSAKLLDLGSEEFLAQLENKDQSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSE8</accession>
    <name>B7FSE8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_9684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177970.1">
        <property type="nucleotide sequence ID" value="XM_002177934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSE8"/>
    <dbReference type="FunCoup" id="B7FSE8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSE8"/>
    <dbReference type="PaxDb" id="2850-Phatr9684"/>
    <dbReference type="GeneID" id="7197545"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9684"/>
    <dbReference type="eggNOG" id="KOG3487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085828_0_2_1"/>
    <dbReference type="InParanoid" id="B7FSE8"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17306" checksum="1ED61CB717BDB278" modified="2009-02-10" version="1">MSQAQSALLLVIVGRNEPLYEANLLASANNPTAAQLQQSETMTRQNYFVTHSALDLVEKAAFTTHSMYLRVVDKVNQQQVSAFLTAGHTKFMLLHGGHRHRHNEDTIRGFFQDLYELYVKVPLNPLRPYDSPIRSDNFNRRVRALANRYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSV2</accession>
    <name>B7FSV2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copine 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CPNE1b</name>
        <name evidence="5" type="ORF">PHATRDRAFT_9816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177730.1">
        <property type="nucleotide sequence ID" value="XM_002177694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSV2"/>
    <dbReference type="PaxDb" id="2850-Phatr9816"/>
    <dbReference type="GeneID" id="7197484"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9816"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020452_3_1_1"/>
    <dbReference type="InParanoid" id="B7FSV2"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="245"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="469" mass="50564" checksum="01951DF5F29C7723" modified="2009-02-10" version="1" fragment="single">PDVLGKTEVVKNTLNPQWTKVFVFDYELGTPMKVAVSIFDEVRKGDNKSMGSAMFDIGELLGARGNTKAKRLKGGGTLFAHLRKSEGSGLLRLKMKGIKLKNVEGMFSKSDPFFELSRCINSAGGDTWDNVYRSQPIKNNLSPDWEESTLPLSTLCGGNKDLPIQVSVYDFEGSGKHTIMGIFETTVNGLVNASTNGAEDVGKAFNLQKKGKDCGSVVILKAEPSVFVPGTPSFVDYISGGCELNVVVAIDFTGSNGDPRKPGTLHYRHPDGSHNDYEKAIASIVNILAKYDSDQKFPVVGFGAKYNGVVRHCFQCGPSPEVHGVQGVLDAYHSVFQSGLIMSSPTTFVEAIETAASRANVTQEAAKRDGKQAYTILLILSDGAVTDVPSTKQCLERVSDSPLSVVIVGVGSADFTSMEFLDDSSGKRDIAQFVQYNKHSSSPVDLTSVTLKEIPDQVVGYFQSKCVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT58</accession>
    <name>B7FT58_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PsbP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177783.1">
        <property type="nucleotide sequence ID" value="XM_002177747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT58"/>
    <dbReference type="PaxDb" id="2850-Phatr43698"/>
    <dbReference type="GeneID" id="7196999"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43698"/>
    <dbReference type="eggNOG" id="ENOG502SS7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_901562_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT58"/>
    <dbReference type="OrthoDB" id="45040at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854985" description="PsbP C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31676" checksum="20E70A509EFC742F" modified="2009-02-10" version="1">MERLLFVAASILSWECSCALAFRGPASTRLPSSLARRLGTRWHGPATTRLAAFLSRRDVVSCLVGSSIAVGTAAPVQADDGDLTSQLFNPDGSLKDSASIVTEAQTRTVTSTWDVSDDLLINADGTNVQTPSGTSVEWSYTVPEKWSAGTGGVDLYLDRSEGINAKACDGILVYQAPGTAKANLLSKASTIGVPQALSMAQAIPGLDKADLISGRTRKNADGLQFYEFDLGRAPKTCEDSAENLGLGFCPFDSLFLISATVLDDKLYVLVVQSDRGEWKRASSDLKRVRSSFAVGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTE9</accession>
    <name>B7FTE9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_43772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177831.1">
        <property type="nucleotide sequence ID" value="XM_002177795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTE9"/>
    <dbReference type="PaxDb" id="2850-Phatr43772"/>
    <dbReference type="GeneID" id="7197282"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43772"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297469_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTE9"/>
    <dbReference type="OMA" id="MQNWLVY"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="805"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="107"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="253"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="605"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1013" mass="115635" checksum="674106A7219A0415" modified="2009-02-10" version="1">MDTRHLKYSFWTGGNFSNSNNSTDFDSNLERPQDVSVDSVLTSLYFNSIVFVMLMASYEILRRVFPAVYSSRKRISHARPDTQNGHRPEAPLHEDATVPDPNGTDYPKIHHERHASLTSLPDDRPLDWLGPVFGVPWSKVRRIAGLDGYFFLRYIRMNVRITAVSTFWFFLILVPIYATGSSKEHSAEGWYHLSAANIPRDGWRMWIPCLFAYLFSAFVCFVVKQEYRHFLDLRQDFLARGNMHVDPQHHHSLEIENIPYELRSDRALKEYFEKMFPGRVHSASVVLNLPELEDASVRCMRTCRRLEKSIAFLHATGSRPTHVVGRGRISCLGIELQPLDCNCTASQETLFVENDMRAERPKRGTRVDSISYYAQELAADSRSLFQMQKRKSRIAESGNQLKQVDNWLDKAVRQASEVANTILEDSIKDNHLTSPYESFDEGGTVPPAESMTSRYGSFSQAISHRAIYGRSKFDKIPEERKEPLVCDDEMSDSTEDSDFPIPFSRDSYQNRWRRWAGRLGLDFAIAGLKLVNKQLDVALEEVVGATMSSTGYVTFLDLSSTTCAASAPLTVKANVLDVSVAPEPRDIIWKNAHISKRSQLRRGNFTNFFLFLGVILWSFPLAAIQAFAKAEFLAQIPGMEWILTFHGGTFTNFMNGYLPVVALLCLILILPLIFEYVAVSYEHRKTYSDVQSSMLSRYFYYQLANIYVSVTAGSILKSLSDILDHPSNILQLLGDSLPTMVGYFDALLVTKIMAGLPMIFLRFGALSRMLFLKTLSNEKKMTQRELDAVYRLENVQYGWEFPTQLLVVVIVFTYAIICPVILPFGLLYFLGALLVYKKQVLYVYSPVYESGGAMFPVVVQRTLFGLVCGQMTFIGYVVTRGCYYQPICLFPLPIGTIWAMNFFRQNYADPSTRLSLERARECDRLSSSKAATEEDGLDSNIDRGVELRRTKFDRKSYRQPVLTELATEPEFYRSGFQDDETFAVRKQLQRINRYIKEATLEHNDGLKDALFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTK1</accession>
    <name>B7FTK1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178165.1">
        <property type="nucleotide sequence ID" value="XM_002178129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTK1"/>
    <dbReference type="PaxDb" id="2850-Phatr44278"/>
    <dbReference type="GeneID" id="7197952"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44278"/>
    <dbReference type="eggNOG" id="ENOG502RAFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870066_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTK1"/>
    <dbReference type="OrthoDB" id="46046at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855315" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30917" checksum="9C86967F7E534B2E" modified="2009-02-10" version="1">MSIMFDSPLCVRLAVLLSVCLIHPHGAFQPSLLPRRLHQSRTLPPTTLPPAGLRIRSRTHPSCSLNAAEKYDKASPSGTADFEFQEMRVQLDALQKQNLVSRNMDPRARAELEHYVRQVALYRPSPVEVRDIGRALPQTRWKLVFATDTATLGDLPADATVLLNFVDHERVDYILQFSEKTFGLNNLKAKSTYTVNPGPGGDEGVVTLVYDKITTDAFGMKDMGVGLFGMLQGRANYIVSAYFDGTFWVERGRGRGRVEGTDYLSVYVRQPDEDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTQ1</accession>
    <name>B7FTQ1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178188.1">
        <property type="nucleotide sequence ID" value="XM_002178152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTQ1"/>
    <dbReference type="STRING" id="556484.B7FTQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr11116"/>
    <dbReference type="GeneID" id="7197979"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11116"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_1"/>
    <dbReference type="InParanoid" id="B7FTQ1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="142" mass="15363" checksum="DCFD8F11A8B2B89E" modified="2009-02-10" version="1" fragment="single">VVVTGANAGIGKETCHALASAGATVVMACRSRARAEQARRDILSRGSCNSSIITESQLPIIELDLCSLRSVRTAAAQVRREYPRIDILINNAGLMMGTQQFTDEDGLDVVMQANHVGHYLWTRSLLPNLVSRRDGVVLNVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTR5</accession>
    <name>B7FTR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178195.1">
        <property type="nucleotide sequence ID" value="XM_002178159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTR5"/>
    <dbReference type="STRING" id="556484.B7FTR5"/>
    <dbReference type="PaxDb" id="2850-Phatr44335"/>
    <dbReference type="GeneID" id="7197818"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44335"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540225_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTR5"/>
    <dbReference type="OMA" id="EFHIPNR"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF5">
        <property type="entry name" value="PYRIDOXAL REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855318" description="NADP-dependent oxidoreductase domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="202"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="505" mass="55180" checksum="8779BE3135D9C65B" modified="2009-02-10" version="1">MMTLSNNVPLFLLTISGTALWLGRESLAFVVVSPPTPVSQRVLVTRGSGNSVPSAKRLPTLRLLSTSPRDGDDEISKLIGKRSEIKRKKKEDDSKPKTDEPIVDLDLDRLPEFRTERPVRRAKQSKEDEQEKDDDKNKKKDDLPTVDFKADYADENDLHIPNRIGITTVAWGDPSRNFVSSGKLSKRMLKAGKFVPGDLQLAYEKLLLGGIVFMETAPTYGAASRNSKLSAEDILKRCMLEVGDGLPEAKIMTGLGASAWTKPRGMPQSLSDSCDRLGQSILEVFQVPKSRFFPTPLLANALAQAIEEGQCSYIGVQGVTNAGTLRKLANKLEAKDVTLTTNAFDYSLTKPDSEYMIDVCKELGVIPIITDPLDGGLSSGIFTATNPSGGIAGSTGKFTFKELEKLQPLHSVQETVAERVSTRVRRDMRTIQDQFRGKYGPPPKINTEITTTQVALNYIVAKGGVPLPEVNSPAQAEEVLGCLGWTLADEEVDMLDSAVALCKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTX6</accession>
    <name>B7FTX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_44387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178500.1">
        <property type="nucleotide sequence ID" value="XM_002178464.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr44387"/>
    <dbReference type="GeneID" id="7198053"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44387"/>
    <dbReference type="eggNOG" id="ENOG502R2P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FTX6"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000029">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1343" mass="147932" checksum="E411E3E578A5C3E4" modified="2009-02-10" version="1">MKSVKKIFQKKNKKESGNTSASLLQAERHESDNSSVNARVEEESLEAAIDLSSTAPGHGLEPQAQLMEPPAPSLKKSALPHVNENRNRPNTNRPKQAMSGQHETKPPLVEENDPVRTADHHQDTPAGRSSYDLIPLLDQTKLPRGGLSIDTKAVGRVQFGLPPETIKDSMQLGIPVPQVYIVPVERFCREMGPALGVNLAEFEFPAYFNFFVYKKRCTLVVDSEDAEDNIRKVFSETLLGPAQFRREEDPLAFEAEDFAKDFPRNAIPNFTKELKHFRIMPDGNELVIETLLEFRHFEMRSDGHEGLGVPPNAEGKVEEQGDGCKSEDEDCGAESDAEEEVPKDLQAVESREQATPWTYSQARFMGDVSTVWPTSATVDQIKERSVPRVEIFKMPGGTEYIIHDVDENNKIIGKARFSGHVKVSELMSVDGFGGHSILDDVGPNCRKSKSFAEERDLSSSADLERWLNEPERILPPPSFHPPSFGVTVLGNSHGFDKSGSVSGYVLWINGRGVMIDPPPYSSATLEREGIRPRTIVGIILTHCHADHDAGAFQKVLTGSPVVVITTPTIYKSFIRKYAALSALSPALLRHSHRYKPAIIGEALRFQGATFYFTYTLHTIPCVGFRVEWRGRSMVFTGDHFNSPPAIDKLQETGILSKARADDLRNLPLQDTDLLLHEAGAPPIHTPLEVLLQLPKEVKKRLYVVHTSALPAGCELRVAPTGTAGTIRLDQIANQSDDHVRRGSRHSASSDSCRDGEYIWNGHSEYESISEEAAVANANVPSRLTVQSEPRTMMNSFQNLDFIGAKERQVRSASCLSHDPHLSYAFTMEVLETAKVDAYAPGAVVVPSTRRSQLLCVVWEGTCTEKISQGGNPRNTGGTLKMIAEGKEIPKAVWHAGDWTGPVALQPDLLLSGESDTSDNHDVVALSTEGVKVITVEFSSLQTILKSGSPLYRKYLDRKAQQGRAKRETSFENGSTATDELYQEAVRSLNVLELLNGNSALRKLSAVQKRHLESLAEGPICFQPGERLWRSGAPVDRAFIMVSGTASFVPKRRNAGSAAVQAKDIVEHDRMGDLSVSESMRADAQKVMRELGVRQADSLGGDESSMSSAEHDDQKVVQFDHVFNRSVSNDTPFTDAHDYAKLSRGLQKRADYLLKEGSREGSVVSNISTDDSLNDMDSCDNESEGQVDYTFTDDADAGLRSKRNSIIRRRSSRARFANKVLGRLYSRRAFTGGLVFSRGHFLGDVSKMVAGLLSSEGVSEVSDDYGSAYGFGDKPEGADYDLLENMTDLVIHEREGDHHVMHSSTLTAGKRGCVVLVFPKASLIPFLDEYPGLLLSVLGTQVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUA6</accession>
    <name>B7FUA6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178288.1">
        <property type="nucleotide sequence ID" value="XM_002178252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUA6"/>
    <dbReference type="STRING" id="556484.B7FUA6"/>
    <dbReference type="PaxDb" id="2850-Phatr10800"/>
    <dbReference type="GeneID" id="7197764"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10800"/>
    <dbReference type="eggNOG" id="ENOG502QQM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034724_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUA6"/>
    <dbReference type="OMA" id="SKFFWLI"/>
    <dbReference type="OrthoDB" id="45797at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289:SF8">
        <property type="entry name" value="DUF819 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF819)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="371" mass="37912" checksum="9D5C0E0C393EF9A0" modified="2009-02-10" version="1">MSLERKTTIGKAISAPLSTMALALTVANLGVIPFSSSVYSMINQYLVPLAVPMLLYDSDIRRVIRDTGTLLLAFGVGAIATVVGTLVSFPILPMTSLGDDGWRVACALAARHIGGAINFVAVAETLQISGTVVSAAIAADNVVVALYFAFLFAISNADQVDGPSSDSGTSDALELDASGSEVEYSEDSISLSSLGIALSVASGLVTTGRILTNSVLPLGTSALPLTSVLTVAAATIFPKFFVNIRAAGSALGILCIQMFFAASGAAGSISLVMQKAPSLFAFSALQIGVHFGVLMSVGRGIFRIPSKELYLASNANVGGPTTAAAMAKAKDWKSLVLPALLVGILGYASATAIALALGPILVRLPLIGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUA9</accession>
    <name>B7FUA9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_10925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178289.1">
        <property type="nucleotide sequence ID" value="XM_002178253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUA9"/>
    <dbReference type="FunCoup" id="B7FUA9">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUA9"/>
    <dbReference type="PaxDb" id="2850-Phatr10925"/>
    <dbReference type="GeneID" id="7197766"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10925"/>
    <dbReference type="eggNOG" id="KOG3493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156193_2_0_1"/>
    <dbReference type="InParanoid" id="B7FUA9"/>
    <dbReference type="OMA" id="CNTHDTI"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000054">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="70" mass="8162" checksum="A5C704B2CF4984EF" modified="2009-02-10" version="1">MIEVLLNDRLGKKVRVKCNEDDTIGDLKKLAAAQLGTSWEKLRIQKWYTVYKDHITLEDYEIHDGMGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUH1</accession>
    <name>B7FUH1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_34011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178594.1">
        <property type="nucleotide sequence ID" value="XM_002178558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUH1"/>
    <dbReference type="PaxDb" id="2850-Phatr34011"/>
    <dbReference type="GeneID" id="7197796"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34011"/>
    <dbReference type="eggNOG" id="KOG3765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666423_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUH1"/>
    <dbReference type="OrthoDB" id="205012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="417" mass="47701" checksum="8E568857781D022F" modified="2009-02-10" version="1">MEKQMVDQQHRRSHMFVLRSSMHFVLRAFLVIWALLSATTTTLLHSQNSFSILPADVAYYMAVSGNNSNSQQEERKDEYKLHVDKAYQKYNFEVDTPTAPVCYPLRAKDVDFTLVTQLSDDRLAMMRPHCKRWGKHTISLAIGTNESRDTVEQALSKSGCDTALITLSIVRDFDSDQKYPVNKLRNVAMSQVRTSHAVIIDADFVLSPNLYETLHLHNKTLAADSTNALVIPSFELRKACRRRNRRCITMYSAMVPRNKDGLLELYDPMTEDSAGYGIAQFDIRGNYHGHASTRYADWASQPAEQLLPIECVTSDRYEPYLVVRHCRDLPPFQEAFVGYGQNKLTWMQQVRRRGYKLFQVGEVFAVHLPHSKSPAFKQWHMVGKANRSLLAVTTIADAFGLWMNETVPDFSQVPYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUT1</accession>
    <name>B7FUT1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178650.1">
        <property type="nucleotide sequence ID" value="XM_002178614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUT1"/>
    <dbReference type="PaxDb" id="2850-Phatr44646"/>
    <dbReference type="GeneID" id="7198129"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44646"/>
    <dbReference type="eggNOG" id="ENOG502SN8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422424_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUT1"/>
    <dbReference type="OrthoDB" id="46385at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="775" mass="86732" checksum="857CF1A2F7EA5D6E" modified="2009-02-10" version="1">MELPLVSDVSQTVYWSWPSDSWLESRDLCFSPHYLVSGGFLIRIIDSIACSADDMKRPRDSRTFTFLLVLGFYSPTLWLSQGGVTAWVGPYRRKVTKPDRVSFPTRCTAALRDDESNIPQRPESSRMNDFVAEFLQKSHREANDDTANPSDTTDDVSKAAACISTSTHLIALPVDACHELLLELESVQRAILYHCPLLVHACIAPAVTRLPLLYVRAPSATAVSTDKLYDIVKKTVADVINQEDAEKTSVEAGDNEVRRDDGTPDTGAANDDNISPLLLSFQGLEIDGTGNNVLSTVANVENENGLLRLQRLVSILRERIHTDTGWDTWLPEDPRLALENDVVADPSFRPHIPFMRLPKNWIDFLETENDDQEVWMLPSEKGGNGISPIFWGQWLDDDFGEARMREVAIYNRQGKEKSLDEKAFYLPARSIPLPEGNAALRKQEAKFEAYNEERILQAEALQRKGTNSANDARDDDPLLSKTRNKLYSLYESSSVPGTETKDSSVLPEQNLVDASKGSDSESFMAPKPQRGNTDELDNWTKDRIRNAIESRAKFRSEIDLAKPKEKPPIQENSVFSKYKEGTLAPTQDQPETTRELPPYPSREHCMGFWRVVSSPTGFEVEEGNDSRSDNIILRVDGTTAGGPILDQETRQKTSGGTWRLMGESKEDAGLLVRLVIPPKKERILVMEGRLERISMSSDLPLASSTFGIPELEARKARSTADIEDLLYCSGNVYIEDAITGQNRDEIGSFSLMKLQTPTDPSKYTITIPKPVRNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUW1</accession>
    <name>B7FUW1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178389.1">
        <property type="nucleotide sequence ID" value="XM_002178353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUW1"/>
    <dbReference type="PaxDb" id="2850-Phatr44673"/>
    <dbReference type="GeneID" id="7197656"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44673"/>
    <dbReference type="eggNOG" id="ENOG502RZ4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_2_1_1"/>
    <dbReference type="InParanoid" id="B7FUW1"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855475" description="Metallo-beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38156" checksum="5CB83F4126C10DF4" modified="2009-02-10" version="1">MTFVRVFLGVAVALRFVATSAFDTPDVFPASTRAALAAKSGSLNPSQGYTTAGWSNRAATVLTPVHLDPNVYTGDRPFYWNRIDVGCRMTVIELPADDSTSGRPDLWVHSPVGLDGPMQQALNQLGNVKYVVSPNYEHLKFAAQWYQSFPQADMWGCPGLAQRMENIQWKGEIPDGFRPTAWKGGPGTQMEPDSGIWDTNIIQPLHIDIEKNPFTGKPFFNEVVYYHQPSKTLLCTDLFWNYPADVVPNSQYGADDTWELAPRVTGIPVGSRLWKFGMDQIYRPFFNNFMVTDQSQYRDVVNHILDVWDVETLIPAHGDILRGRTLIRQALREHFQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV34</accession>
    <name>B7FV34_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178854.1">
        <property type="nucleotide sequence ID" value="XM_002178818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV34"/>
    <dbReference type="PaxDb" id="2850-Phatr34528"/>
    <dbReference type="GeneID" id="7199494"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34528"/>
    <dbReference type="HOGENOM" id="CLU_1323164_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV34"/>
    <dbReference type="OrthoDB" id="48084at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="21397" checksum="1D18F8DE8F657859" modified="2009-02-10" version="1">MKETGRCRLSHYRVFSTRTPTDLRETYEFLDISSDFNPISATKALSPDDLAWGTMLALLLAVLATFLQSRRSQNDFVPSRIEPSLADNWRNSTAKTFIDNTTSATPFEEWKEISKPENYVWYNADLRAKQQLRHTMPSTYTFAQGWTLVALFVIFAPIFSFEFALTVSRQILCALERTQGLCDPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV41</accession>
    <name>B7FV41_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178859.1">
        <property type="nucleotide sequence ID" value="XM_002178823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV41"/>
    <dbReference type="STRING" id="556484.B7FV41"/>
    <dbReference type="PaxDb" id="2850-Phatr44970"/>
    <dbReference type="GeneID" id="7199647"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44970"/>
    <dbReference type="eggNOG" id="ENOG502TMNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386122_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV41"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053943">
        <property type="entry name" value="RlmKL-like_Mtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054170">
        <property type="entry name" value="RlmL_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313:SF1">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22020">
        <property type="entry name" value="RlmL_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RlmL ferredoxin-like" evidence="5">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="4">
        <location>
            <begin position="444"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="710" mass="78585" checksum="544D2B8A3F7BC881" modified="2009-02-10" version="1">MASRIPFRHLFAARSYFVCSQSAETTVCLRGNLGNVRGFQNVPYLPRQATSVDVDFYRSKAKTLKTEKNSGASWKKPSVASSQKLRQGRKPRGSELGQRFDSMERSSFNQRKRFSSPRRSESPHTNTHSRRPFQTERFGRATQASKPSYARYRGAEGPQIGVQDHYRASTQSRKPFRAERSGRTTQATKPVYTKYKDTEAPRIVRQERSRAQPPNRRLSPVARLDRALLAIKPKDGAERKPRATPQIVRRTRRFPPNQLDVEVTCHPGLETVLSQELDALGIAHKIERNCAVLTNANLDTILSCHLYLGSASQVLLQCGTPFTARGLPELQRKVEKLPWKNLIKTDAEVQVKVQATFKSKLLHSTAIRDRIIDGIKLSLGVLKKNPESDSSKSLERVPLKVPQESKGPKNEDGSQGPAVALTVRVMRDQVYLSLATSLTPLHQRGYRLESGKAPLREDLAYAMLYNSGWKPPSAARGESDTIAYDALVDPFCGSGTIAIEAACMAAGLPPGRLRSAPLEGTLFYDPAKWSKIVMKSLRESSSQTNETKIVCSDRNAGAVKIAKANAKRAGIPDMLDIQECAFTKHPWLDVYQKGVKPRSLLIAGNLPFGQRISPSKSSSSKKKPQFLPLYQSLSTIVKSYGDQSNGGTCNIVLLTNDWNLVQRGAFPGSVKQGLGFKHGGIDVSTALINSSSGETEDNESTEKQPQKIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV49</accession>
    <name>B7FV49_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multifunctional methyltransferase subunit TRM112-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179078.1">
        <property type="nucleotide sequence ID" value="XM_002179042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV49"/>
    <dbReference type="FunCoup" id="B7FV49">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FV49"/>
    <dbReference type="PaxDb" id="2850-Phatr11462"/>
    <dbReference type="GeneID" id="7199499"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11462"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086140_2_0_1"/>
    <dbReference type="InParanoid" id="B7FV49"/>
    <dbReference type="OMA" id="THNMMAC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14733" checksum="4774022F48157A54" modified="2009-02-10" version="1">MRILTHNYLQSNVKGTEKGYPLLIEPNRVVVEESPVNLSMLQTLLPKLDYSAIVQAARQLATYEDANEAFTVPDLPDLLPETLDDLFLTALYKFLFDLHVIEGHLVCPDTGRKFPIKEGVPNMILHEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVG6</accession>
    <name>B7FVG6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178702.1">
        <property type="nucleotide sequence ID" value="XM_002178666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVG6"/>
    <dbReference type="STRING" id="556484.B7FVG6"/>
    <dbReference type="PaxDb" id="2850-Phatr44738"/>
    <dbReference type="GeneID" id="7199716"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44738"/>
    <dbReference type="eggNOG" id="ENOG502STZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_974746_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVG6"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852684" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="286" mass="32298" checksum="E9DE8F5D3868372C" modified="2009-02-10" version="1">MPWQVGGKSKGFLFLLLAVGAPQRSGSVPYMLLSSGGSKCVSVDAPRHTTLRVDYFVPDLMVEDEEELKLETDAVNSVSETEPRTEEGLDSRFNDYQKRRMELLKKARHGRKGHDTNILMYQREEGSTFHRRGKANPTGSGKIRQQIDQRAGSVEFRTGEVDGPVEVCVQSYSASRQLPVRVALNVTSKASEEPPVIPLQYADIAEQLNVHMSKITVDLKRSQEKLKNIMANAGYAREMEVGFHGKSLSLSTAIRYWPMFRMAVLIFAGFLQVRHVVQYMKSRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWD4</accession>
    <name>B7FWD4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179364.1">
        <property type="nucleotide sequence ID" value="XM_002179328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWD4"/>
    <dbReference type="STRING" id="556484.B7FWD4"/>
    <dbReference type="PaxDb" id="2850-Phatr45072"/>
    <dbReference type="GeneID" id="7199934"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45072"/>
    <dbReference type="eggNOG" id="ENOG502QVMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWD4"/>
    <dbReference type="OrthoDB" id="43293at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="947" mass="104566" checksum="2757460444C35D52" modified="2009-02-10" version="1">MASPSNEDRSDQDAFVGEWIDKYFVELDEVYRGRIVSQSAHSTNTHTNSNTDTHTSALWKVYYPADPTKSYPDSDVEELDWDEVQTGIALYRQRNGKEKENGKTKTFATRTSPRTPSSNQATSPRTFVSSATSTSISTTSASSTSSTTTTSSTTSLPKVRRTSRRRSVTQSSYRDEASVESADDETYRTARRSPRTRTSPPRALDAQLAVEPPSKRSRTAVSRSTTRRSSPTSSRSTALPCAFAVLMGARPAPRKARTAKDSVANAPSHHPSSAPEHGPLLVPPTRTQTQTPTTSHAVEGNPMADGSRFVKKPYTAGDDLPVLAQPHAMFDDLVANLTDHGRNIHVLWPLVETFRSRTLRVATMCSGTEAPVLALDLLQTSLRHALRRHAADELRTRGIDVANVLRIEHVFSCEIEPFKQAYIERNFRPPLLFRDIRELGQPQAYTAYGALRDVPNRPGCVDVLVAGTSCVDYSNLNNQKKHIDQKGESGQTFHGMMDWVDLAQPPIVIIENVSGAPWEIKVKMFEERGYAATFLRIDTKEYYIPQTRKRGYLFAIKAQTKNKVVDRPARWTAAVKSLKRPASAALDDFMLPNDDPRVLRGRARLTAESSAGEGEGRTRTVDWTKCETNHQQARSMEELGDKRPLTNWSDSGNTAMPSFGWNEWTNAQVHRIHDLMDINALRLAKLMIDCSHKTMVWNLSQNVHRDTMGVLGLSQCLTPTGVFYVANRGGPLVGEELLMLQGIPAEDLLLTKESEANLKDFAGNGMSTTVVGTVMLCALLHGHDILRGGNEREASSAVVPSLVPRSITAPSDASISLEFAHYAKEKLELGPRSSLGREDWSKLLSAASSSSKKCITEGKYESLPPGELVTCQECGFTSKVVAGMESCGQGYSLRVGCYRGHIPLQGDYPHPHLDGAFWFQEWRTAGDAHIKVQNHLVTFCEATFGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWK8</accession>
    <name>B7FWK8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179400.1">
        <property type="nucleotide sequence ID" value="XM_002179364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWK8"/>
    <dbReference type="STRING" id="556484.B7FWK8"/>
    <dbReference type="PaxDb" id="2850-Phatr11781"/>
    <dbReference type="GeneID" id="7200196"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11781"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1144468_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWK8"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="106" mass="12142" checksum="E6955CF8BE318AE5" modified="2009-02-10" version="1" fragment="single">DKADVSLITLTSRTFDGAISDGNVWLIEFYAPWCSHCTSFLPTYIEIAEEFHKSDKRIKVAKINGSEEKALASRFDVYGFPTFYVIVGWSVYSFEGQRTKQNLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWL1</accession>
    <name>B7FWL1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosome biogenesis protein NEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_11653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179402.1">
        <property type="nucleotide sequence ID" value="XM_002179366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWL1"/>
    <dbReference type="SMR" id="B7FWL1"/>
    <dbReference type="FunCoup" id="B7FWL1">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FWL1"/>
    <dbReference type="PaxDb" id="2850-Phatr11653"/>
    <dbReference type="GeneID" id="7200198"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11653"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="InParanoid" id="B7FWL1"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19246" checksum="F2CD18D0FED10971" modified="2009-02-10" version="1" fragment="single">FRPDILHQEILALLDSPLNKAGLLKIYIHTQTKVLIDVNSSIRIPRTYKRFAGLFVQLLHKMKIKAGTESTTLLKVIKNPFSQYLPAGTHVYGMSCQGKLYSPISLAKSLLPATLEASKQTPTCFIVGAMSTGHITLEDHPYIEHMFSISEYPLSGAAALSRIMGGVEHHWGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXI2</accession>
    <name>B7FXI2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179563.1">
        <property type="nucleotide sequence ID" value="XM_002179527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXI2"/>
    <dbReference type="PaxDb" id="2850-Phatr35081"/>
    <dbReference type="GeneID" id="7200485"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35081"/>
    <dbReference type="HOGENOM" id="CLU_1135389_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXI2"/>
    <dbReference type="OrthoDB" id="45753at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="158" mass="17825" checksum="7893CB9CA08CE037" modified="2009-02-10" version="1">MTPLPVSEAVQLGDALFLSHLAYVDDYHLIQEHLRSVDNDAFALRNCTTSSQPNQPAHFLVVRKIASPAPTNTKCFLTPERKLLIHQYLPFFFRPEPLEVVLTIRGTKEVGDFLSDAMLAATEHQDGMAHAGILKSTRWMLKTYTDDLQQIVERFSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXN7</accession>
    <name>B7FXN7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179800.1">
        <property type="nucleotide sequence ID" value="XM_002179764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXN7"/>
    <dbReference type="PaxDb" id="2850-Phatr45432"/>
    <dbReference type="GeneID" id="7200544"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45432"/>
    <dbReference type="HOGENOM" id="CLU_1051555_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXN7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="265" mass="29207" checksum="D47B1828A27CEB51" modified="2009-02-10" version="1">MSFMPPSSNSETFSLLPSAVRAKENHQMATNIVGNSDNSSNGDFVYAVLDKKLDSGNVESKFGNAVSVKIAIPTDNDADREESGRLIPFSAFLTECNRETMEQLAELRSRILNLEDHVDSIQTDLVKEQRRGNELQATTTDLKSQVDIQENEFMARLNNVQELINDSIENQLHSSESFRDRLASLMAVGGYNPILQTRSAKSVEERNGFDSKANLIRSVNSNVRSQLAEAEAILETIKKQIAFEIAGASTNQNADSDKIGCTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXQ7</accession>
    <name>B7FXQ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_11894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179598.1">
        <property type="nucleotide sequence ID" value="XM_002179562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXQ7"/>
    <dbReference type="SMR" id="B7FXQ7"/>
    <dbReference type="FunCoup" id="B7FXQ7">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXQ7"/>
    <dbReference type="PaxDb" id="2850-Phatr11894"/>
    <dbReference type="GeneID" id="7200686"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11894"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="InParanoid" id="B7FXQ7"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="209" mass="23152" checksum="EEBBAB494C94792A" modified="2009-02-10" version="1" fragment="single">YSQVAKEQGLRSRAAFKLTQINRKYPVLEKAQNAVLDLCAAPGGWTQVAARTCNKSVPIIAVDILPIRSFANAQNITTLIGDITTDKCKSDIKHALQGRPVDVVLHDGAPNIGADYGKDAYEQNEIALHALRCATQHLVKGGTFITKVYRSRDYASFQWLLQQLFQGVQAFKPKASRAQSAEIFLVCEKYKAPSKLDPRLLDPKHVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXT6</accession>
    <name>B7FXT6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179823.1">
        <property type="nucleotide sequence ID" value="XM_002179787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXT6"/>
    <dbReference type="PaxDb" id="2850-Phatr45471"/>
    <dbReference type="GeneID" id="7200699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45471"/>
    <dbReference type="HOGENOM" id="CLU_346999_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXT6"/>
    <dbReference type="OrthoDB" id="49100at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="814" mass="88840" checksum="A8A3E8AD6AC7494C" modified="2009-02-10" version="1">MARTSRGSVPKDSVDALDNLNLDDMFADGGDDLFGGLDIDLADMGDITAGGIDAKVEPMTVEALPTGVAGMTDEDETTPNRRKTKRKLKNPTLFEDDDDYLEEPALKKKRKVSKIATATVRKKGTKKAADESTPTLPKAIKTKKGKTATSITNGSMQTLGARGSLGSSSSGVAAAGRFGKRSSDTAPKTSKKANSSGKSNSGLLPSPSSSISNTAQSSSTLITAPTHSAQQQILQHPGLSQSSFCGLRPSNTIFYPFMPAMPTEPTLRNRKLYAVLDRTYSSFMSHLSALPSPSTAGNGAAKPPALEFEVIVKLMNEAFKDEKSATGAHHRGEQMSAAIGAMRRTISFFDKSKLAGDLMAICALLKRQFDFLHQNTVNMERWCKGNLSAEEYGAVYISTKTSRKANATKSTSVLSSFTTPLIRVKIVCSNGFKEPRRGPLVAVLPSKGVMGITKAESAMSPPKTTTKKSSTKKRVVAVARDVKSSTVTSSAQKEMSYVNMKASRRRKAVAELIARTARELEVKYTHRIESRTQIIDKQQQEARRVCEADPIVVIHTTGMWKWLDKSGYFLRTTDDDIQRSVDGLVSPDDMFVKQMELQTKADTVTNQPMRSDESVELSLFHRLQSLLVSGTGTEVDEDSLESDKEEEDATSHGESLPMADLARLSIDERLFIQLQSIGLAQSLSHRRLLSQRRSDTLSPSKEKSDRTSLGSENSGARQHMEVIHSENAIDELKDIITAMTDDLGRLNSLSSNRIAFLESIAVANGPSMEEIKRKNDEEANAIGKCHQLLKKAKESRVKNGKLKNSKKDEYALPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA3</accession>
    <name>B7FYA3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179702.1">
        <property type="nucleotide sequence ID" value="XM_002179666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA3"/>
    <dbReference type="PaxDb" id="2850-Phatr45615"/>
    <dbReference type="GeneID" id="7200657"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45615"/>
    <dbReference type="eggNOG" id="ENOG502SXZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1605924_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYA3"/>
    <dbReference type="OrthoDB" id="37555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="166" mass="18510" checksum="0710A5F603E6DE50" modified="2009-02-10" version="1">MTIPVETAPQQNEDGTALWGANRAEESASTTPCDPESSAAEDPDLEIAADSDDDDLTVIVLHPTNDENNRQQEMISWIEQAGPEMENRRRNVLLRELRRVQRASFFHFALLCLIPTILLLIVVATVVGEDENCESEATFCTLETRTFINAFTTRCICDAIPIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYD2</accession>
    <name>B7FYD2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179717.1">
        <property type="nucleotide sequence ID" value="XM_002179681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYD2"/>
    <dbReference type="PaxDb" id="2850-Phatr35386"/>
    <dbReference type="GeneID" id="7200672"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35386"/>
    <dbReference type="eggNOG" id="ENOG502QZHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1279858_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYD2"/>
    <dbReference type="OMA" id="IAGYIMA"/>
    <dbReference type="OrthoDB" id="45182at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="24190" checksum="11EC3F6C12F7ADFE" modified="2009-02-10" version="1">MQLGKLIINALASNFRAPGSGIRGWISMRMMKKLNADKSVDAIRTAFGESLPNKVWLELGPGHGFATEYILNYKQPSKVHGVDISEAFRSGLRAKFVAEIENGRFEIHDKDANNLSFADGGSIDYLFGLNVLYFLDPLTEYLTEFHRVLAVDGRMAFGVSDAAIDLNKSYFVNTDWQLCRRLMEEAGFLDVVVGDERQAGKDNQTYRIITARKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ20</accession>
    <name>B7FZ20_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180265.1">
        <property type="nucleotide sequence ID" value="XM_002180229.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZ20"/>
    <dbReference type="PaxDb" id="2850-Phatr45889"/>
    <dbReference type="GeneID" id="7201122"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45889"/>
    <dbReference type="eggNOG" id="ENOG502RBNG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226240_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ20"/>
    <dbReference type="OMA" id="ITEIRIW"/>
    <dbReference type="OrthoDB" id="119388at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2496"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="353"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="420"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="514"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="541"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="554"/>
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        </location>
    </feature>
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            <begin position="633"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="2498"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="2508"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2520"/>
            <end position="2530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2966" mass="322283" checksum="42711AC532073746" modified="2009-02-10" version="1">MNSDLQAIMARRRRLAEAKQEVDVAKAGSTAGRAKQPQSGFLTSPKGSIPTSNTDAKKASPDLQAIMAHRRRLTEANEDDGDEVAPGAPGVSPSYRRGTMGDTSVSPIYKKRSMGTTSVSPIYKKSTMGDTSVSPSYKKSTMGDTSVSPSYRRDAMEGSLTDLYAELATSKSNLSQGSHSQMNSSLELHQSKSGEDLSSIMERRRRIAEGDGGGPSPPAPSPPKKSPRVNYALSPTLAPGEKPSAVSSPLNESLKSFGVSSDLQSILARRRRLNESGEQGQSLGTAERVRSPKDRKSVVPSPPLVADTLEDEAETGVALQSAQSGRSQLSAASTHSRQSNRDVARPDPTELASSSSHSHQQTSSSRHSPSDIPGSASVGEISVASSQNRKSESSDESKASSQDKAVEPAALAIPVPVIELARKEDDFSKKSAEESAPKSSPTTTNKNDFVSSSSDDDESLEDTLSSEDTEEREQSSVAQRDLQKNAPTYTEESMTLSESLDERVARLVKAAESPPQTKGPSKASTARRRQHNDSKTSGHSQSKKASPRLRPSRRSHDSEERSVQSKDSQETQRQRRASRRSNIGSSDEEHMSLRSLAKANRRGSTGTKDSDEHSRSAESAGSSNRLRSRRSSTVGRTLRQSSSAENLESDETIPSSRSRSPPSRQPHEQGHSASELQSLDVAGEQKPSNFANKPENSEHAADDKTEDEAINSGWGDFPIFAPKDGLEKPITGTEKNNSLSSSQNVSSHLDVTDRFVVSPNVDRSSSAEADGHFEPVLTSVADGFDDATFGNGTFDRPTATNGQTSVSARVFDSGFSPDAFEATNVFGSHVFNEGFAGPETFEQPHFGLKESIMPQWDSSPWERAPLRRCGKLILDQQDFFSTDFACAPTSNLSNGNVIFACSGKDGFFLKEIDPSRNSVPVCSTPVLTIDLQRKVSSKYNVSIYKVHALTSLTSGLHESHSQSRVRVASVLEVNVLESPQLMKIVAVWQWGYGTAQPIVLQYTITPPSGADYTFDAATLQIADNLVFIAGSSPKGPCVFITKPAARDSWSANFLGGSGFVSALAVTTTSERAHPFVAVGLTDRSLSVWTYAEAMKPASKDSESSKRWLFPLCRLEAGSVLSSRESKNFVSEEPSDADSKEVGYCTHFAWMPTVPMVSYTLMLAASFQNALAIYHVELPATMDPSTNSVRPLSPPTHISVLSQAPLLGPMVAERWRGRHERSSAIWLNRGPHVDPCLALLCHTGSTNGSAVRLAIGCLIFSQYDGVPVPEDKMVPFRLLAGVTITNANKSYPLGIVPLPRHPCVICHSRNKLSRFVPTLAFDNAIQHRMAWMAQPPASIPPGLSSVGDRLLTDTDNDAQGVLHIFSTLQFERRASTDSSVVWGQPVRRYWLCRTIAGDNRTIGKGDLKNEKLEKDFGRSDRVNGGSASRAVAALADVSIADLVPFRIVRCRGKEICAVLFQHGFRSQSTELELGSNDAVAVALVDFSTPKTILQVVEGRDICFCFDGQTDFPQGLLLSKDGSMLTSFSWQSMASKFETGRSYRPILGVEVGDQYIECRRVFAFSGASKLVLVMSGISHQNGTTHILAGDLRSDAEVSITKWSSLLPNMEIGRSFKVDRQEEVLSIIGLEHDDSGYRNFAVATSERVFVLSAGLDLCAETTIELSFPSLVPMGSFAVCFISQDKVKYLCCLDADLSLGVVASLPTEQYGDRSPLLLALRQDRIILNDIHTGVRLVEYGQSPDGFLLPACRTHPALILEPMVANAVCVGGKQHRSTEILRTVIEKFGRKVASITHGDDEGIGHFGAGLQSKVFEILRFYGLDQAASWLLTGTVQFTRTANSKILPTWLPIGLKRSGAINSDAFLHLVSSGDQYLLEYLKSPNQNLPATIPRSTDASSYFSHDFAMDSLGHGIPSEAVKSFDFAGSSQADNLILQIALILQKDRSQDITEILRKLSGYDEPMFSRSSEYCHVPGSLAALAVSLKSSKSNTNRQVMSSDHVERWMRPLAPSLQRGATFGRTRQKLIGESDFINACSNSDEGSDNFWSIPCNEAKHVWNEGPRKAKDKLLMLDSTEEWLGRRRPAILGKEGVSAARDRGEGALAGILNNEEDSFGVMSDNESIGDDWVDGVGEGRSDEANLSAYFRMSEGDDEDSQWQTEGLLDISPYQIKATVIGDAGAYRLQTSTSGVDEGEPGKVRSLHDLVFERSGEGVPSGLAVPAGRGSSVDVGVLHRPDRQSRQKCSIEFWYYLPKKSAIVTDIILTRRTMGSTADDLSKVSISSEKESVLWDLVLLQSGEVQFRSCGGATLLSSKNNNIGAAKVVTNNQDEEQRKDIVAYEHWNHICVVMNSRDLDLTECFVSLYMKGTEVASNSLSMLLPGYEKGDLADQSTLDDLLHKSQLIFGVNSTPGFRITEIRIWACSRSADDTQAMMYEYLNAAETKKKFKVKIKNKKGGALGKGGLASPLMDTGKGAAKSGTAFMLKGAPPLDSSGKMQLETAADASNRFSLAPPSTKQDERERKLFEVSNPSSTFKNSSDAFSISATENDKSHPLSYVGVDKSRQLTPSVEEVQQNETHPPVTSTLWDTALPLSQQVRSSAAAALIRGPPATRHFGGNRGGLPDFSGMERFGVGGVAICGSEKTIVWRDNEDPPALTYPIGASGAIVSDQMDDEGSEFLCCFLAKEKRMVVFELQSRTVVVELQMTTKLNFWRFLPPEADENTLCFMLITPVGGFHWMPLEESPRPHQVWKRGPELQGKKVVSYEEGGSNGLDDSHILSRVGLVLVTKPTGDGTLEAWIVPISGDSQASQFSEDVMGACFCQPPHFDEGPFLPLLVTVHLSHERIVVNLLTTRELSKGSIELGEAEVTQEIDDTGFEDVDYRPPSLAMGDMPEALCCSLANIVVVIVRRKGLVVAYELEDGELSLIASENVGHFVIDAVMRYSAEVGGAEIVMLLSDNEFPKDGRMVSFCFRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ88</accession>
    <name>B7FZ88_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_27447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180109.1">
        <property type="nucleotide sequence ID" value="XM_002180073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ88"/>
    <dbReference type="PaxDb" id="2850-Phatr27447"/>
    <dbReference type="GeneID" id="7200827"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27447"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020452_3_1_1"/>
    <dbReference type="InParanoid" id="B7FZ88"/>
    <dbReference type="OrthoDB" id="36246at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="79"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="331" mass="37579" checksum="1195788CFA100593" modified="2009-02-10" version="1">MEMAMKVIVWDFRRHGKHKMMGEFETTIRGMTGDKSSRSKPYVDENVAHRKDHKEKAMSAQSSRRPEFVDYLSGGCQISLAVAIDFTASNGDPRQPGTPHYFHPPESKEWNDYEKAIFAVGSILAKYDSDQRFPVWGFGAKYNNVVRHCFQCGSDVEVEGVQGIMDAYRGVFRTPLTMSYPTIFTEVIQTSASYARHEQVQSKLSYTILLILTSGNVENMKETKKHLIEASGEPMSVVIVGIGDADFSGMEFLDEHDPDRDGGRDITKFVQFSDYKSFNALTEAVLDEIPEQLVTYFYDRKILPGKLEDYDENDLEVESADDDERTFTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZS1</accession>
    <name>B7FZS1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin extension protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hUbi</name>
        <name evidence="8" type="synonym">UBI4</name>
        <name evidence="8" type="ORF">PHATRDRAFT_56440</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180197.1">
        <property type="nucleotide sequence ID" value="XM_002180161.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180198.1">
        <property type="nucleotide sequence ID" value="XM_002180162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZS1"/>
    <dbReference type="FunCoup" id="B7FZS1">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZS1"/>
    <dbReference type="TCDB" id="3.A.25.1.1">
        <property type="family name" value="the symbiont-specific erad-like machinery (selma) family"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr51931"/>
    <dbReference type="GeneID" id="7200913"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56440"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_7_0_1"/>
    <dbReference type="InParanoid" id="B7FZS1"/>
    <dbReference type="OMA" id="NIQKESX"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="42876" checksum="26B0A756C7EEFF6C" modified="2009-02-10" version="1">MQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZW2</accession>
    <name>B7FZW2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180569.1">
        <property type="nucleotide sequence ID" value="XM_002180533.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZW2"/>
    <dbReference type="PaxDb" id="2850-Phatr35923"/>
    <dbReference type="GeneID" id="7201229"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35923"/>
    <dbReference type="HOGENOM" id="CLU_000850_0_1_1"/>
    <dbReference type="InParanoid" id="B7FZW2"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="742"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1289" mass="142462" checksum="5BC797D3F0087E3A" modified="2009-02-10" version="1">MDPLEHVLVNLLGATTLDSSYRRFFEEYGITQASELASITEHRLATVSYGVLTPAVGDGPAAIVRTFLPPAQQDRILKIVQWFLSKGTNVTNDTWLELTSDVLEYWQPASATVAPATPVGSDARSSFVESAAAKFRKTIKNHSVPYPKFSEDRFWVTWNTNIRIKLRIHGVQLVLDPDYLPETVDETDTFVEMQNFVFGVFNDILLTPRARGILHKHVDELDAQSVYRDLVASYGKGINAQITATSIETKLTLYSFATSKSKTCVAFLTTWRNLIYDLERINEFPLPDHQKSVRLKSAVRSHPQLKLFLGNVQLYSRTHVGKSADDSDFEYVYDLMLEHATDIDQTDLEDRGNNRGGRSANNAKFQSSSKKKTNKPIGKKHKNYVPPEKWNALSPEEKRTIMDQRGPRPAPAPAPALSVNAAATQPPPTVYVSDSTAVDNQSLASTHVPPAAGPGHLLRSLISNSAARQHSAPSNGATSDSFSVNGTTYRREVNRASVQYRLSTHDVSLNKDSLVDGGANGGLSGSDVTVISQSLSEATVSGIGNSELTNLRLSTVAGLIHTTDGPIIGVFHQYAHLGTGNTIHSCNQMRSWGVTVDDVPRTFGGKQRIVTSDGRFVIPLSVSGGLTYLSMQAPTEEDLDTFEWVPFTADNEWDPNSLSSPAAADDDLSLQLPVGHVPFRDERINNFGLLAHSAAVSRSPLNVDALQPNFGWVPSARIARTFENTTQFARADARLPLRKHFKSRFPAANVSRLNEIVATDTFFSDTPAADDGIFNHGGATMAQLFVGKSSQITSVFPMKRESQFAHTFEDFIRTHGAPDALLSDNARAQIGKQALQILRMYAIDDMQCEPHHQHQNYAERRIQEVKKMVNTIMDRTNTPPEYWLLCLFYVTYLLNRLSVESLNWRTPLQVAHGQRPDISALLLFRWFEPVYYYDPDHASFPSHSREKTGRWIGVAEHKGDALTYWILTDNTHQAIARSVVRPANVDNGLKNHRAADSSPDGGEPSNPKPIVLATSDLRHDATIDPSFEKSHAFSPDELIGRYLIREAPDGQSHRALVARKIIDADSDNHQAIRFLLQIDEKDADEIISYNELSDLMEAQQSEPATNGNIEDHFKFTSIIGHQGPLQPTDAGYKGSSWNVLVQWEDGSQSYEPLIEMAKDDPPLLFWKGETKSPACSVSSTSQWGVSTGMTVLNTGSRDGAHYLGRGTQGEPVETNLVCLATNPDTDGFGQAQSQLSIQKHDVTVSGLDRYHAKKHGNYDECAHGAVYNTVENSETDHDGAWQIVGPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZW5</accession>
    <name>B7FZW5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_20424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180571.1">
        <property type="nucleotide sequence ID" value="XM_002180535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZW5"/>
    <dbReference type="STRING" id="556484.B7FZW5"/>
    <dbReference type="PaxDb" id="2850-Phatr20424"/>
    <dbReference type="GeneID" id="7201414"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20424"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_1_1_1"/>
    <dbReference type="InParanoid" id="B7FZW5"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="704" mass="75987" checksum="9CA576CF0F99B5E3" modified="2009-02-10" version="1">MSTNTVSEITYDLPPFDKYRGQDSFFGGEPPLSEGVGYLVVLGFGFLFSIITTILVYLNKYFGARGEVTSEHFNTAGRMIKTGLTASVIVSQWTWAATLLQSSNVAWAYGVSGPFWYASGATIQVLLFGVLAINLKKVAPSAHTVAEIVNARWGKTAHLTFLFFCFAANIIVTSMLLLGGAATVEALTGMDYRLASFLIPWGVILYTASGGLQATFLASYIHTVIIYAVLITMIFLVYIKFYSSDQIYDFLDQTVSFTTEECEAIFSDDSGTFFEAGKYACGPVSGNEKGSYLTMISGDGLMFGIINIVGNFGTVFVDQSYWQSAIAAKPSSAARGYLLGGVCWFAIPFSLATSLGLASTALMLPITSTEAGNGLVPPAVAFELLGDAGAILILIMLFMAIVSTGSAESIAVSSLVAYDIYRQYINPEATGDQILFVSRVVIVVFGLFMGCFAILLFEIGLSLGWVYLFMGVVIGSAVVPLWNMMTWKKASGTGAVIAAWTGLVLAVTGWLVAAKVQSDTISVDALGTNEVMLSGNLIAILSSGAIHYVYSMFIDPQDYDFSELDKHITLVEQDTRGLTDEEKDPVALRRAERWITRRGYALTLVLIFIWPILSVPAGVFTKSYFAFWVLVAIAWGFGAALVITILPLTESAEDISMVLSGVFYAVTGREPRRAEDPAEAVAAEKEISEEMDKADAEVAAEMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0J8</accession>
    <name>B7G0J8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_12799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
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        <property type="protein sequence ID" value="EEC48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pti:PHATRDRAFT_12799"/>
    <dbReference type="eggNOG" id="KOG3090">
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        <property type="entry name" value="Prohibitin"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="244"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="244" mass="27510" checksum="14A3C35CECFDBF24" modified="2009-02-10" version="1" fragment="single">NSVYTVQGGHRAVVFNRLVGMKETVYGEGLNFNIPWLERPIIYDIRTRPVNLQTLTGSKDLQMVTIAIRVLHKPNPNQLVWIYRMLGINYDERVLPSIMNECAKAVVARYNANELLTKRDVVSKEISFDLEKRARIFNIQLEDVAITHLAFSPEYARAVEAKQVAQQDAERAKYIVLGAQQEKKTIITKARGEAESAELIGTAVRQNPGFMKLRRIDAARDIADIVASSGNKVYLNADSLLLNL</sequence>
</entry>
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    <name>B7G0M1_PHATC</name>
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            <taxon>Phaeodactylaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180704.1">
        <property type="nucleotide sequence ID" value="XM_002180668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0M1"/>
    <dbReference type="PaxDb" id="2850-Phatr36184"/>
    <dbReference type="GeneID" id="7201210"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36184"/>
    <dbReference type="HOGENOM" id="CLU_539148_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0M1"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855690" evidence="2">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
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            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="506" mass="52918" checksum="8F69377F35DE2667" modified="2009-02-10" version="1">MKVALALVTAYSIAVVTDAAITFSDLEAGTTNGSSEPSDEQRLRPFSRKNSGHGRTLKNKKSNETPSGSGGKGDTFPVGSEPPSPSPKSGGERPAALPPYSTGSGKSKRKQPEESRSMKKSDKLKIESSTSSKSGKGSGSGKRSGSSKADSSQGKGKGKGKGGGVETAAPIGCASDVAQTILSQVNEVITRNPERCCSFDGPTAVFVTHALADSSTISGFEPFWDNIYGGIESASDSAGTCFVMTGYDSQATPTRDLADILVEVNLVASTIGGVSAMMSTDPSEDVSLIQTIRGIASNPVLPHIGIFNTGYNNVIIEAIVTGFARLPYIGYLQDSDYGKEAGRITLQLLSGTNATPLCFNARPDLTFINDRCATYYNEVTDSSVIPPTGVQCNTASTVDGIVSKIVDANANAVWSHVDCCSAVADAVARVRSMGKSVIAGCMDMDTSGGKVNFITTQPVDLQAFQASTWVNFPLLQEMDGNDGRGVQYFPSLQSLVNTAVFNIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1G2</accession>
    <name>B7G1G2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_36473</name>
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    <organism evidence="1 2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181025.1">
        <property type="nucleotide sequence ID" value="XM_002180989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1G2"/>
    <dbReference type="PaxDb" id="2850-Phatr36473"/>
    <dbReference type="GeneID" id="7201587"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36473"/>
    <dbReference type="InParanoid" id="B7G1G2"/>
    <dbReference type="OrthoDB" id="53525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="229" mass="26954" checksum="192D0ED17EF2EE5B" modified="2009-02-10" version="1">MSTVDAESKWEGESIRVFPFTGKDKKLWRAWSRKTLAVGKGKKWEKALTHDLNIEEIQKKEKKLSDEERKALSMNDAAWSYLVWACQDRAFNIVDKVKDNVAFKAWQMLKKKYEPKEVDAYIQLQDEFQECKMESDKDDPTIFIEELEVINGCMGAIQDKYEKDDVEMISHIFSKLPVSYSEFITSQKTKGIQNTSVEDIKDALKEYWKRTIKTSTKTRKTERKERRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G272</accession>
    <name>B7G272_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial splicing suppressor 51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181158.1">
        <property type="nucleotide sequence ID" value="XM_002181122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G272"/>
    <dbReference type="PaxDb" id="2850-Phatr37124"/>
    <dbReference type="GeneID" id="7202254"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37124"/>
    <dbReference type="eggNOG" id="ENOG502RZZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575521_0_0_1"/>
    <dbReference type="InParanoid" id="B7G272"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="1">
        <location>
            <begin position="251"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="463" mass="51787" checksum="397470079CA24056" modified="2009-02-10" version="1">MATHHYRICDRPTSHPIQRRAEARCCVPWDRRARNDDDNDSKLYGHTGAFFVDLAAFTPASVGESDDDDDKPRCTELAVDGCEPMMRERDLADRTSAADFRAIADQALFALEDDYRTTLDSNSSARSSGPTIETDEKLPTPIVLAFETENTETEWQTSFERCKEEIHTRVANGVKSQPEADSTAVLNAVRSIREHNPALERKLHVWEQQHRQESVTVPHTHRLVPAAPLSAFRKNTAKARTATAHLSRAATIAHALVRLDVLRSQETLSVHVVGCDAVECATDETVRLYFGPLARWLAVAAEAPKHLELHLIGPNIPIEASQRKPMQLLSSAVSSSRPTRLKSAKVSSHLAVYDDYECNTRADLIVCFNAGIWGYTEWKPTLHALALRKQNIPFIATAYTLLEAEDDEDTILDVLKELGIEKSVASLWDPEMNPFGSKQPRETATAKVGQDYRENSAWQAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2A2</accession>
    <name>B7G2A2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181343.1">
        <property type="nucleotide sequence ID" value="XM_002181307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2A2"/>
    <dbReference type="PaxDb" id="2850-Phatr47052"/>
    <dbReference type="GeneID" id="7202144"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47052"/>
    <dbReference type="eggNOG" id="ENOG502SHEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046790_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2A2"/>
    <dbReference type="OrthoDB" id="38831at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52949" checksum="D0F9B17B824FF4DB" modified="2009-02-10" version="1">MSTMNSPFSLRTTRFRLPSRLSPPNVAFSSRENPRSRVQFSTGQTVLVAAFFSSVAAVLTASIAIYGFSNTILEAHRAAGVLDATGGASQALAKFRSISEQRSALRCAEVGPKVSNQTKGFNESLPDVRDHFDPSVEPQAKALTIRIKRETHSIRPHVAWLMSFPNSGTSFTIHMTRDVSNTTTATNYALEGTNRHDPSEQAIPGPLGASGPFLELIPNLTTALPDTILTKTHCKGFCSGRKCNAEKTVHTVRSFMMGCLSGRRAVRNTKGGLSTVTVTYNPALVKKAIHLLRHPLDNIVARFHLEYNVQVGRGNTEYDKMYPKNVTGFHKWCAAEDAHDHIINSRFLIVDHRLKEKMINIPCMNEFFRYVQWHNLAFAVSREMGLSTMILHYHEYADNFEKTRDKVLDWLELPRVGEGMAFHSGKVYRHYYSDKQKRAIWEFLEEFSSLETWAELKDYNFKLKPNSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2C4</accession>
    <name>B7G2C4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181356.1">
        <property type="nucleotide sequence ID" value="XM_002181320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2C4"/>
    <dbReference type="PaxDb" id="2850-Phatr47071"/>
    <dbReference type="GeneID" id="7202157"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47071"/>
    <dbReference type="HOGENOM" id="CLU_916638_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2C4"/>
    <dbReference type="OrthoDB" id="49047at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852869" description="Lon N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34384" checksum="7EBA9D65C4BE884D" modified="2009-02-10" version="1">MQYGFSITCALLIARVSSAFFLPSRAPRFRLESPATAENIDQTFILPIFPLRKAVKLPTESLKLNLYEERYLLMSEHILRQAEDKRMFGAIFCSDKAQMVKAGLGPIVPIIRSGDIGLTFFVHNVDECMVPTLGGELRRRIRLLGSGIHGFQVKRVLHSGFGDETKSLPYIMVEAVPLFDITDTQLKPAVIEFSKKDIRGVDLYQSLELRDEESIENCEENITFWNNDSVDLDLLQRFAEKASKQILPSTFRQELLSFACTSKKLDESSSLLRHQALSTTSTRDRFDPTGEKASLDVSPSVWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2R6</accession>
    <name>B7G2R6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181428.1">
        <property type="nucleotide sequence ID" value="XM_002181392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2R6"/>
    <dbReference type="STRING" id="556484.B7G2R6"/>
    <dbReference type="PaxDb" id="2850-Phatr47175"/>
    <dbReference type="GeneID" id="7201955"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47175"/>
    <dbReference type="eggNOG" id="ENOG502S35N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063995_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2R6"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37909">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37909:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41205" checksum="7C4529DF958E7FE6" modified="2009-02-10" version="1">MARTKVSFGTVPATRFKHSRIVLVAALAALAFLFSQETFGWTEIPAMATFLPCETDVVYRGPAGIPALRTRADLGPLMQARGFTHGAEVGVQSGSHAKQILQAWTSCERFHLVDLWGHQENYKDVANFHQSKQDELFQATQNLLQPWREIVTFHRMLSTQAARQIPDQSLDFVYVDARHDYCGVTEDIRAYYPKLRPGGILAGHDFLSVAEQKVVDSSQDWSVCMDGTVNAGAVKGAVEQFALEEGLTFSVVYAERQNGAYRSWLLQKPTRMECVGQMGGYGSDLVRKVVVGHSTRVEIPCFEPTQKSYNRKETFFRKDEGLVEALGKDKSLIASHYFCQGEHSRAVLACQRLASLRPMVHENTLPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G352</accession>
    <name>B7G352_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181727.1">
        <property type="nucleotide sequence ID" value="XM_002181691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G352"/>
    <dbReference type="PaxDb" id="2850-Phatr47374"/>
    <dbReference type="GeneID" id="7202422"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47374"/>
    <dbReference type="eggNOG" id="ENOG502QPTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030392_1_0_1"/>
    <dbReference type="InParanoid" id="B7G352"/>
    <dbReference type="OMA" id="VIVTWEA"/>
    <dbReference type="OrthoDB" id="541403at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525">
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="75"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC46941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="557" mass="59622" checksum="0B1058EDCAAC5767" modified="2009-02-10" version="1">MAMQDSALADPLLDPNVTPSSHEESSQGTPDEAVVSAESPCRNPASPSAEGGDDPQVDPSTGRDPWKNHNVRLSLVMCACFGVADSIWGSVVLSGFLYALGGAMGQASRDNTLVGTAEAVEGLTQLLTAVPIGMVADKFGKAKVVRAGGVLMFATIGITVWALMIVKEDAEESTEAAKQSYYILVAALGLWGIVNGISYGPSQALFSDSIPKGRRSELLTYLYSCYLLSSTIGPIVGIVLLLTVSKNQDDWSLKEIFPVFLVGVCLEIPAAGLMFFFDDKHAIPENEDDEAVPRTPLTATVGFPSDTVADVREEAEVEVPRNLSKKIVPYVLFLSSLIVSLGSGASVKYFPLFFKELGLGSAAVQGIFLVVPISISGLSFVSQSISKHLGRVETTVLFNMAGVSLLFFMTWLSNRVEQGDSKRIGIIVVVYLIRTGIMNCTYPLLESILMDSVKSNERAMWKGLESISSFGWTGSALIGGVLSDKHSYQFTFAITAIMQLVGGLLLLFIRPFVDPETESSDTSEACESQSASLVYTDEVTDQDNANGSLPEPLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G355</accession>
    <name>B7G355_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37571</name>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="19003" checksum="41728D9D5455BFDE" modified="2009-02-10" version="1">MLVGDVPLAFLTNFGCYIHKTGAFDSVLGNNFLLYAGTQPDGSIGCGLSVDASPLNPSEETWFYDFSTETWTKTVFAGSRPPALIDVQGVYIEPYMYAFGGFKYECPGDGQVYNPDTYRYEVTLPTPRPTVSPTSMPTKEPEPNATSGTLSSTGFIKLAIIVLSFMMSQNNLYP</sequence>
</entry>
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    <name>B7G3J3_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Phaeodactylaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181800.1">
        <property type="nucleotide sequence ID" value="XM_002181764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J3"/>
    <dbReference type="PaxDb" id="2850-Phatr47491"/>
    <dbReference type="GeneID" id="7202272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47491"/>
    <dbReference type="eggNOG" id="ENOG502S7QA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3J3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="24377" checksum="D3004D575CE98471" modified="2009-02-10" version="1">MLVATHSRPPMIPEGPRRTHPGRRNDGHRPHRLHSIVSDGRTTTRLFPTTSDAVRIGGHDCRDDLWGEHALVTDKVFMNKRNANEPPLPRISHTAKGLLTHRQLEVLPVFGITTRSDTTELDSSHTVFGQILSDESSTEFLKIVQDLPTYAVERPTSMKINGGSTDPGKENVVQDAAQAVFNAQRGFFRGAAKSLGDTRVSKVYEGKLLRRVEVTQVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3T8</accession>
    <name>B7G3T8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_37441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181493.1">
        <property type="nucleotide sequence ID" value="XM_002181457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3T8"/>
    <dbReference type="STRING" id="556484.B7G3T8"/>
    <dbReference type="PaxDb" id="2850-Phatr37441"/>
    <dbReference type="GeneID" id="7202317"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37441"/>
    <dbReference type="HOGENOM" id="CLU_1139886_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3T8"/>
    <dbReference type="OMA" id="IANTIDC"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="244" mass="26897" checksum="F7922D3054C7D37F" modified="2009-02-10" version="1">MPPPERDFELKNLKIRVSDQQSQLAVIITHPWGLLGGNMHNNVVCAAALYFQRLGITTARFDFDGSIGRGHAQVDQLLTVAQNMLDGKFSIDEETKPTNLLLIGYSYGALIAASATSQLHSICVALVCIAPPFGVQHWLLCFHAKYHMEQAAASPDLPRLFLLGDKDNFTSEKAFTDTIASKFPTQVSTGAVLKGADHFFQRREKDVLDVVGEWILETFPICGGDLHKLKYSDFGAPNAHSRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4U5</accession>
    <name>B7G4U5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_21897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182135.1">
        <property type="nucleotide sequence ID" value="XM_002182099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4U5"/>
    <dbReference type="STRING" id="556484.B7G4U5"/>
    <dbReference type="PaxDb" id="2850-Phatr21897"/>
    <dbReference type="GeneID" id="7202930"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21897"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="InParanoid" id="B7G4U5"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="37803" checksum="059E1659A6E14FE7" modified="2009-02-10" version="1">MSTSEIQQDTAREEVPSLTQQIEKVQKSKREHSGSAAQGSPVRAPSAAKLRRTLKGHFGRIAALHWGGDSKTVVTAGQDGNLILWNAITSNKLQSIGLKSSYVMAVGIEQTRGNLVACGGLDNLCTIFPRNNVGKAAEMASHDGFLSCCRFLSEQEIITSSGDSTCILWDINTHKPVSRFEEHTADAMFLSLRPSDRNVFVSCSVDQTCKVWDTRAPTSSTLTFTGHTGDVNGVEFLPSDNNCFASCSEDNTVRIFDIRASDELAKFQGPASLGESPSDGLTSLAVSKSGRLVFCGDSEGNFSCFDILSERSGPAYTNTGAHDRYISCIGISPHEDAICTGSWDTQAKVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5F0</accession>
    <name>B7G5F0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_14572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182237.1">
        <property type="nucleotide sequence ID" value="XM_002182201.1"/>
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    <dbReference type="AlphaFoldDB" id="B7G5F0"/>
    <dbReference type="FunCoup" id="B7G5F0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5F0"/>
    <dbReference type="PaxDb" id="2850-Phatr14572"/>
    <dbReference type="GeneID" id="7203188"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14572"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050757_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5F0"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U2-type prespliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="219" mass="25335" checksum="85ABCE2E8DC7CD2C" modified="2009-02-10" version="1" fragment="single">GSKFGGGGVSSAQQGERERKERLKQLALESIDLAKDPYLVRNHLGSYECKLCLTLHRDEANYLAHTQGKKHQQGLARRAHLEKLKLEQEGFSGLPTVDVTQAAPIQKVRIGRPAYQVYKSRDSETNQRCLSFELQYPEIEEGLQPRHRFMSAYEQRVESPPDRRYQYLLFAAEPYETVAFKVPNESIDKGEDRFVTHWDVETKKFIVTMYFVEDRQKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G603</accession>
    <name>B7G603_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182491.1">
        <property type="nucleotide sequence ID" value="XM_002182455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G603"/>
    <dbReference type="PaxDb" id="2850-Phatr48104"/>
    <dbReference type="GeneID" id="7203270"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48104"/>
    <dbReference type="eggNOG" id="ENOG502RQMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751151_0_0_1"/>
    <dbReference type="InParanoid" id="B7G603"/>
    <dbReference type="OrthoDB" id="46333at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41462" checksum="14B1FB29F0904F3F" modified="2009-02-10" version="1">MTNNGRLRYIRTRRFGVLDSRLPPPPSPEAATTTVGCRGVDLLKTPLPVLELSNVLLHAQRHRTDQVRSQFDEFLRTHGFVFLTAPQSSQPGRIIRDLRDTVHHDLFPNQLEKNDELPTSQNIYWSEKNIPMYRLGYEFCEDGMREVFRVAAGRVDDQPWPDAGGRARSTTLRALGLVRHVCDTILDLLLSGQQTKIPIEAGAKSKDMAVRKPRPGSGSSTWWSPHGQSPSYTKQLVGTIPDRDEDYSVWYAMHYFNTTPLRGETIVTLKAHVDPSLLVVEPFLCPYTRGLQVWNRTTGTWMDVDGPASPVSSLWETGQEVMLLFGGKALGAACNLEPTLHRVVLGSEPRSTVIYEQKYGELFPPPISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6K6</accession>
    <name>B7G6K6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="11">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GapC2a</name>
        <name evidence="14" type="synonym">GapC2b</name>
        <name evidence="13" type="ORF">PHATRDRAFT_51128</name>
        <name evidence="14" type="ORF">PHATRDRAFT_51129</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
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    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:57604"/>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
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    <comment type="subunit">
        <text evidence="2 11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002182551.1"/>
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        <property type="nucleotide sequence ID" value="XM_002182554.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="reaction ID" value="UER00184"/>
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        <property type="component" value="Chromosome 16"/>
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        <property type="entry name" value="GAPDH_I_C"/>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
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        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
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        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
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    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
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        <ligand>
            <name>NAD(+)</name>
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        <location>
            <position position="121"/>
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            <name>NAD(+)</name>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
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        <ligand>
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        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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    <feature type="site" description="Activates thiol group during catalysis" evidence="9">
        <location>
            <position position="177"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="RuleBase" id="RU361160"/>
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        <source>
            <dbReference type="EMBL" id="EEC45874.1"/>
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        <source>
            <dbReference type="EMBL" id="EEC45877.1"/>
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<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Q0</accession>
    <name>B7G8Q0_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48881</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
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    </reference>
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        <property type="component" value="Chromosome 19"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="43"/>
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            <begin position="63"/>
            <end position="86"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="EEC45210.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="592" mass="66671" checksum="C34409C58E29DFC6" modified="2009-02-10" version="1">MVQIRREDVRRRSRAFGRSFVGFLRFLLVSALIPMLFLVRFWWTTHHGIPGLAVDNNLRMPPLQVNDNDPADPVSAGTQLDDDSVDVPSRPIISDVARKGDNVKDNQPSASSISSTLFDFLNDFDFTKRIPLGSDVVELYHCNVPKVLSEPLRRSNFTAWAEPLVNDAVAASIKAAARTGVSSKQPTGLTSSEIDLMRKEFVLEILEMYANAQGLCDFEMYQVPSVPITTPNLEAIQTRIRVLELDAVERRDENLARIIFVIVAFRDVDHLERLLHAIHLPQHVITIQLERRTESAFVAAVHNLVQEYENVFVLQFGTVLYKTDSVSMINYRIMQWITLELELEYDFYVTLDGASFPLIDATSLAQTLALSPRRIWLGEMTQKGAVVNDESQSVLLKQKRLIFTAGAPKLHKRLPRRTFDDNSIPQRIRAAMTRKTNSGNQGIYRREIVSLLLESAAVRELFAISKYGCCCCLEERNWVAALTLIGCQTEALEQPSIFQVWGGAMTCGSSMNNAVLSRNESLCYRTEDATRSTGTNRTASTTADFLGNETWDYLQDAKAQGIFFARKFSSDDPSSVQLLEQIEDQLWSSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Y0</accession>
    <name>B7G8Y0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183671.1">
        <property type="nucleotide sequence ID" value="XM_002183635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8Y0"/>
    <dbReference type="PaxDb" id="2850-Phatr48938"/>
    <dbReference type="GeneID" id="7195225"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48938"/>
    <dbReference type="eggNOG" id="ENOG502S61B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131002_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8Y0"/>
    <dbReference type="OMA" id="RITECEE"/>
    <dbReference type="OrthoDB" id="4350at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853092" evidence="3">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="277" mass="30472" checksum="647AD213965506B9" modified="2009-02-10" version="1">MKFVLASTLTFTAVHAFAPLAPRCGKPFVVPTKTVLADDKGGMFFASSDETQTPEATKTTKDDQSLEEEVEAMVQKALKKNKIISNLRSERGNEYAPWMGITENDENEIRKIMRDKAEVRRRRRDEELTVRGALLKDSTVQELSGTGLKSKVVDGTSVELEWSTGGETSTKGFIIKRRAAKQPDFEVLASYETYGPLVSKGVEGGDYRYLDENVGYGSWFYRITECEESGLENDMSQCLVDVETDEEQRGAVLAAGAMALAAVAAVVAGSLLDPVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9M8</accession>
    <name>B7G9M8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_39797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183801.1">
        <property type="nucleotide sequence ID" value="XM_002183765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9M8"/>
    <dbReference type="PaxDb" id="2850-Phatr39797"/>
    <dbReference type="GeneID" id="7195613"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39797"/>
    <dbReference type="HOGENOM" id="CLU_1622213_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9M8"/>
    <dbReference type="OrthoDB" id="546064at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00454">
        <property type="entry name" value="TrHb1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="164" mass="18723" checksum="EFD9A3ECEE6DE824" modified="2009-02-10" version="1">MPKESPLIDRLGGTPVLKRTLDVHYERVLRDSLLAPFFKGTKMSSLRLHQLKFLRYFLSDGRMTVDVTDVMLEKHMSMFEERDLSAVHFDRFVTLFVDSLKACGVRSQGLLDETHEIMAPLRQIFVIGAQEYGGSVKSQEDAETSKEHNRKGLRRLLGLGKQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9T8</accession>
    <name>B7G9T8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="3">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_15777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 reduced [2Fe-2S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183949.1">
        <property type="nucleotide sequence ID" value="XM_002183913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9T8"/>
    <dbReference type="FunCoup" id="B7G9T8">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G9T8"/>
    <dbReference type="PaxDb" id="2850-Phatr15777"/>
    <dbReference type="GeneID" id="7195678"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15777"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583276_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9T8"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06208">
        <property type="entry name" value="CYPOR_like_FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000008">
        <property type="entry name" value="Ferredoxin--NADP reductase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015701">
        <property type="entry name" value="FNR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43314">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000361">
        <property type="entry name" value="Frd-NADP+_RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33065" checksum="C75CC688A2E1A892" modified="2009-02-10" version="1" fragment="single">KPAAPVPAKVLSRRRLIADDAPGDVQHIIMSLPKGLHYVEGQSLSVIPPGTNPQTGRPHKPRLYSIASTRYGDDLRGNTVSLCVRRAEYVDPQTRKVDPTKAGVCSNFLCDMVPGTIVQVAGPVGKTMLLPDIGNSNNEKANQQDIIMVATGTGIAPFRAFLRRLFLENTVAKQMYQGQAWLILGVSVTGGLLYADEFERMQQPSNTNWPGQLRVDYAISREMKNQQGGKLYVQDVLSEEAEMLWTKLEDGAIIYFCGLKGMMPGILEALEDVAKARGKVWSQTLRRLKANGQWHVEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAX9</accession>
    <name>B7GAX9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184155.1">
        <property type="nucleotide sequence ID" value="XM_002184119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAX9"/>
    <dbReference type="STRING" id="556484.B7GAX9"/>
    <dbReference type="PaxDb" id="2850-Phatr49534"/>
    <dbReference type="GeneID" id="7195862"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49534"/>
    <dbReference type="eggNOG" id="ENOG502RXD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032014_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAX9"/>
    <dbReference type="OMA" id="TECWILM"/>
    <dbReference type="OrthoDB" id="41513at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="610" mass="67242" checksum="15FE701F552BFA50" modified="2009-02-10" version="1">MAVPVSVAPERHDRGSLLEVESMPDQIIYVKFLMKGNAIDTLELQPLQDVHRGRCAQTSNSSATTDDTVVTRVQCESTVHLTMDPDKALELDIRSHNEWSWNEFWYPPSIPNELQLWRKENMAIPMCYLMVGTMQGLVRPLLNVYPLDLNATEAQQTTLATVATLPAALKLLYGFLSDNVPLCGYRRKPYMALGWLSASLTMMILGYSSNLSILYADDNQPIAPGGAPSISFLTGAFFVFGTGMWLADVMADSLVAQKARLESESMRGSMQSSCYVARFLGLLLAAPISTLLYSRHGASRIVLMLTIIPIAMAPLVYCLREDRNGPIPSTRDQCSELWKTACSRSVWQPMAFVYVFNVLQVSNAAWRQYLKSVLHFTSAEMNSLLIASYVLLYVGTLTYKCCFLHASWQRIYQVCIALNALFSGLQLLLIRNVTFGLSPFVFALGDDAFSEFLEGVQFLPVAILMVALCPPGSEGASYAMFTTVWYGHCVCVYELGHDVGSSYQHREMLAPAISTEMLGIWNCSKETLESGNLDGLFKLTLLTTIVQTLPLACIGWLPRGRTELETLSEKQYSGSPIGGGIFLAVLLGSMAWTLAVAILNVGYPGWGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB87</accession>
    <name>B7GB87_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184424.1">
        <property type="nucleotide sequence ID" value="XM_002184388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB87"/>
    <dbReference type="STRING" id="556484.B7GB87"/>
    <dbReference type="PaxDb" id="2850-Phatr49620"/>
    <dbReference type="GeneID" id="7198282"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49620"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_995581_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB87"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="31622" checksum="4321D07817064B58" modified="2009-02-10" version="1">MAKTQRVAKLQARKTMSELTNSNAASLKMKMANAADPESDHSRSIARGGVACPFNWRLHDMLDAVENEDLTSIVSWQPHGRSFTVYKPKEFVDKVMTRFFSQSKYASFQRQLNLYGFSRLSHGPDKGAYFHYCFVRGDREKVRGMVRRKIKGNKVRRALTVEEEPDFYDSVWHRAEHRGLAPIASISPEPPCLETTTSPSTKPEKPVLLPKPANTWEAFEEVNDHDLMLFAGTSKLLDDDLLLDNVLLGSPYVQGSRYAEGVINRVTSSTTLSLDYLCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBB6</accession>
    <name>B7GBB6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184339.1">
        <property type="nucleotide sequence ID" value="XM_002184303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBB6"/>
    <dbReference type="PaxDb" id="2850-Phatr49646"/>
    <dbReference type="GeneID" id="7198140"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49646"/>
    <dbReference type="HOGENOM" id="CLU_629258_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBB6"/>
    <dbReference type="OrthoDB" id="56058at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="436" mass="47894" checksum="2AB7916BCE0111D1" modified="2009-02-10" version="1">MNTEPSFANQRSRRLLSMTRSASKKPSRSGRLEEQRVGSFSQLHRYDPDITMFEDNPLANTFRITDVSKKASKESKRPGLFKWFRRSARDLLHYPPHSLANEDTTAGSTSGSLPQQAMAPASVLATPTVKQENSRALLLSTMELSRDAHQVFGSFRNQAADQQHSPHGRGVVSSSIPTNSTKPQATDPVLGSILRVPPRQKSAARHPDAPLTRPRSGRFRSGLARTQKARSFRAPQPRLVTPPPRRPSTTRSHSQQNLQNSRRREQKDIFVNFSETLHDDGVPLNVDFGWTAAGGSTSVHSASVHSEGSSSLSSGPDSNSRASRTSSRAYSCRKPGPQSTLMEIAPGLFLPLRTTAETLQAVQRDTLLTHDCVSCTAALYCMQQAEVIVCPYCRVIEPLRHGQSGGAVGMGFGARDLWEMRNAIAVKDDDDDVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBV4</accession>
    <name>B7GBV4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amine oxidase</fullName>
            <ecNumber evidence="12">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PDS2</name>
        <name evidence="16" type="ORF">PHATRDRAFT_55102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 a plastoquinone + 15-cis-phytoene = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol</text>
            <dbReference type="Rhea" id="RHEA:30287"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:48717"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; lycopene biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chromoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184512.1">
        <property type="nucleotide sequence ID" value="XM_002184476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBV4"/>
    <dbReference type="STRING" id="556484.B7GBV4"/>
    <dbReference type="PaxDb" id="2850-Phatr55102"/>
    <dbReference type="GeneID" id="7198353"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55102"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022687_1_0_1"/>
    <dbReference type="InParanoid" id="B7GBV4"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="UniPathway" id="UPA00803"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000091">
        <property type="entry name" value="15-cis-phytoene desaturase, chloroplastic/chromoplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014102">
        <property type="entry name" value="Phytoene_desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02731">
        <property type="entry name" value="phytoene_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF45">
        <property type="entry name" value="15-CIS-PHYTOENE DESATURASE, CHLOROPLASTIC_CHROMOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0957">Chromoplast</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853100" description="Amine oxidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="15">
        <location>
            <begin position="81"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC43911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="589" mass="64390" checksum="36F3B40FFC92F808" modified="2009-02-10" version="1">MKLVFSVAVLSCWNAWAEAFAPNTNVPFHRIAKAQSSLSIVQAPDFSSVGSHLEAQANVEYLKKLARPDKPLQVIVVGGGLAGLSTAKHLVDAGHRPIVLEARSLLGGKVAAWRDTDGDVTETGLHVFFGAYPNALTLFDELKIADRLQWKPHQMLFAKPGRPTREFSVFDFPPLPAPLNAAVAILSCTDMLTWPEKIRLGIGLIPAYLQGQTYVESQEHVTVQQWMEQRGIPQSVTDEVFLAMSKALGFIGPEQLSMQCVLIALNRFLQETNGSRIAFLDGSPTERLCEPLKEYIEARGGLVRTNVPVKRILTNLDENDSVAGLLLKGGEVVSGDAYVNAMPVDALKKLTPEPWRKMEYFQRMQKLRGVPVMNLHLWFDRKLSTVDNLIFSRSPLLSVYADMSEACEGYASKHVSMLELVLAPAAKYMTKSDDEILQATMLELERLFPQEIKADGSLAAVTKFTLVRTPTSVYETLPGMEAARPTQKSPISNFFCAGDFSSQKYLASMEGAILSGQLAAKAVADSYVNAASNDQSAVVAPPRQLTPRPADPSAADAHDVVPDRTMYVAKVASHIPASVQEELEGAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBW7</accession>
    <name>B7GBW7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184521.1">
        <property type="nucleotide sequence ID" value="XM_002184485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBW7"/>
    <dbReference type="PaxDb" id="2850-Phatr40570"/>
    <dbReference type="GeneID" id="7198457"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40570"/>
    <dbReference type="HOGENOM" id="CLU_001650_12_1_1"/>
    <dbReference type="InParanoid" id="B7GBW7"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="59571" checksum="889E93812E5B3D17" modified="2009-02-10" version="1">MSDIAPNNPTIDDAFNAVVVDGTVQANVAPVIEHPNVANENPVFPIVVNHYDNLLAMTGMNIGTRKALVSEGFGSMSSLVRLITKDLDSLVDMMNKQHRGKSFKSTYPPGTADNEKEIHIGFNSKSTLSVIIHWAERLKRLGKEVRAEDYTSEVDQLARDRMEEEKEIREVAKTQTPVKPTPLKDMTKWRSFFENWHQYMSCCRGPSLTPLTYVYRTQEEPETAPLEDYDDMDAYLVAQTILSGPKFVIDNKRVFDEFKEAITTTGPGWAFIKEFNKGKNGRAAILKLKAQAEGTLNESIRRDDAIKILSTTTYSGPSRNWNIDTLLQKFQYAVSELVEIDGASLPDGQLVTYLVQALKDPSLSYVRDTIRTNATYRNSFHEAQLFVKTFVSSSSIKTETTPRQINDVQTSNGGSGGGKSGGGGKGGSKSGPIKGPVTARSYSPGEWKSLTKEQQEKVKSMRSKKKQVSKPSEEKERSVDSVSREDTAGIKEDHANDKSQPIDDAAGLQFGRGAHKKSVGFVMDKASPSGNGAKKQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCD5</accession>
    <name>B7GCD5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184695.1">
        <property type="nucleotide sequence ID" value="XM_002184659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCD5"/>
    <dbReference type="STRING" id="556484.B7GCD5"/>
    <dbReference type="PaxDb" id="2850-Phatr49938"/>
    <dbReference type="GeneID" id="7198634"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49938"/>
    <dbReference type="eggNOG" id="ENOG502STE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853817_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCD5"/>
    <dbReference type="OrthoDB" id="48834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="36939" checksum="2281E6D0DA2DDA63" modified="2009-02-10" version="1">MMDQNSMRKRFLFGDGRRANRGPLDTPNQGETFETESMDPQLAVHPRGPLQGYPTLIQQYLLQQQTAMAASSMDLRFADRTVGGTFGFVPGQSNVMPQNTSFLQPNNFLGSNNMRLLELMQQKHLQQDSFPTRNSGPYIGNMSGEGDPYAENGILGPWSASSAGLLGNMAATIATEGKSKKTRKKPKDRPKRPLSAYNFFFKEERQRILEDLPEGEEKEQPSSSCDKNEQDGGTRKRKKRPHGKIGFESLAKMIGQRWQELEPEGVEYYKKKADADTQRYKEEMKVYSTKCKTEESVLTESDEIIQIEEASPSIEDLEQSSKYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCG5</accession>
    <name>B7GCG5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184707.1">
        <property type="nucleotide sequence ID" value="XM_002184671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCG5"/>
    <dbReference type="STRING" id="556484.B7GCG5"/>
    <dbReference type="PaxDb" id="2850-Phatr49965"/>
    <dbReference type="GeneID" id="7198652"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49965"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023333_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCG5"/>
    <dbReference type="OrthoDB" id="45159at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37087" checksum="B107EA2D59B82B1E" modified="2009-02-10" version="1">MFQYRPPGYGEAICERPFAQGPEGKAGYQGLRKIEIARTNQSIKVLCMVYTHSKKHDNLRSVVETWGSKCDGFMAASNVTDASLGAVNLLHEGPEDYGNMWLKVKAMWQYAYDHYRNDYNFFHVGGDDHYVIVENLRYTAATGNWHGPWNQSSPLYLGGPMADKFESTRYCGGGSGYTLNRVALRQLVEELLAHPDCWPHWRAPDEDRIMASCFRRTGLQCMDTNDESKESRYHPWDVNYHAQWTKRQGGNWWPSLLETRQGIPQPEGLGQISKSSVSFHLKPIKENGRNDLPPDKGMRRYHAILYGLCDNHTTGTSNTTTLRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD25</accession>
    <name>B7GD25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_50132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185058.1">
        <property type="nucleotide sequence ID" value="XM_002185022.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GD25"/>
    <dbReference type="PaxDb" id="2850-Phatr50132"/>
    <dbReference type="GeneID" id="7198839"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50132"/>
    <dbReference type="eggNOG" id="KOG2051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249878_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD25"/>
    <dbReference type="OMA" id="DFQHHQI"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="626"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="832"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1414"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1477" mass="163213" checksum="9E3BC8C4EC4F9D59" modified="2009-02-10" version="1">MSGRSSAASSASATGRGGGSAGRGRGNTKGRGKTGGRGPKPKANASVSKETGASTPSLQTDSSGNANKALPTKDRGGSGRENRTKPNPVGSKTQGNQKRNTPNPPTLSPKDQQRHQEIEKHAQEVAAEKARAVALARAQAAAIKVREQKQADVDQKVREARDLLQNVINATHAHQRTRADMEPETLQAFRKTFQANKKNLKTDLKKCTTFVKKVKSGVAWSMKPEDIVKDVSTLNLSRYVEEVANGILESSTKPKVSELPSVLSLVTTMHQRYEDFLSMLVPALWKVVNAKPTPAMAKLRRLYVRILTELVLNGIVTETKPLIACVTDASGANASQGTNCSVQDANLMVAFSKAAGFELLDIVPTSVHSAIKLIGNYNETEACTPDGADAIFPSQDVIKQAYPVVEQIPSVLTERAVAAQVSEVLVTHCRAAYHALSTNLTQTHRKLLQLEKRCEQDRLLSGSLTEAREKGLVDARKLQESLQKAVDALADVLDERLPILQQQEEDGDADGSGGLEVWTKGTDGEEDLGPFDDEEMRTFYCDVPDLLTTTPPALLGLAPEAIESRKLDNQRKYGAEGEVVDEGDDGTELPLGSQEEFENEEDEELKDEEDPEIEEQKDTPHYRLMVLLEEELPECHRREQLDELTEKFCTNHGSSKNSRKRLSRTLFLVPRSRLDLLPYYSRMAATVDRVWTDIASPLVADLEHQFHGQAKFKKNQNIESRMKTARYIGELTKFRVAPPIVFLRCLKRCLEDFTGNNVDVTCCLLESCGRFLFRLKHTSGRIATLMETITRLSKAKNLDERHQSLIQAAFYAVKPPPSGPRKQQKEYPPLEAYVRYLLMVRLEPTDTSVSFTAKELIRLPWSDPEQQCGALVCRIMLKACRKGRYRTIYAIAAVADRLRPQRSACEAPVRLVDALLEELRWALEHPDFRDQQRTITYARLLGELYCSSQVTGQLVINQLYDFINIGHEIPNALREASQKLAASQGEESGEQLPLFTSMTGVSQTIKEDEEMEDDNLDAAEQAPAPPTPVAVSQHSKYDPRVPSLEDPPNASYRVKLVCTVLEVVAKSIMSRSVLPRMRGFLAAFQRYLFTKTTLPTDVEFSLLDTFDILDSQWKRFTRTSRDKELEEGSESGFPRYSSWLDAHNVTVAFEESDALLELQKRNHVETLADESKTLGDLHVSMDAHSLNDDSASLLEDEEDDASLSVSAKGSVAEDTNDDETESGDSDEDYEGVTEDDIDSESGGNSEEEEEEFDEEAYMRQLEEEAFERELRRVTIEALEKGKNTSRKLVAENMVSGSQTFKKKPTDLSKPVGASSAVAPTFGLAGTPGITFQLLKKGNKGKVEAKEIVVPSDTNFAKVASKQDDAAARERNFIKQRVLQYEADSAEAELSGGNVYLEQERLQVIRNRPLSMDDIDRNFGTRGGNTLQSGKDKGRTGAASGDRPGTSVILGQRGGGRGGPGRGRGGRGNTSGRTLFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD60</accession>
    <name>B7GD60_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_16606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184996.1">
        <property type="nucleotide sequence ID" value="XM_002184960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD60"/>
    <dbReference type="STRING" id="556484.B7GD60"/>
    <dbReference type="PaxDb" id="2850-Phatr16606"/>
    <dbReference type="GeneID" id="7198859"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16606"/>
    <dbReference type="eggNOG" id="ENOG502S3MR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083159_1_0_1"/>
    <dbReference type="InParanoid" id="B7GD60"/>
    <dbReference type="OrthoDB" id="6379857at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043448">
        <property type="term" value="P:alkane catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050526">
        <property type="entry name" value="Rubredoxin_ET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47627">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47627:SF1">
        <property type="entry name" value="RUBREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="14501" checksum="0C8B13DD55ABC4C8" modified="2009-02-10" version="1">MSADERAIRAKQKRADELRAQEVFMKKSTGKHKCTNCDWEFDVEKGDSNMIGGMIKPGTPFAELPSNWRCPVCRASKDAFEEVVEEIPGFEVNQGYGFGTNSWTSEQKNLAIFGGLAAFFLLFLSGYAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDN6</accession>
    <name>B7GDN6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185244.1">
        <property type="nucleotide sequence ID" value="XM_002185208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDN6"/>
    <dbReference type="PaxDb" id="2850-Phatr50312"/>
    <dbReference type="GeneID" id="7198973"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50312"/>
    <dbReference type="HOGENOM" id="CLU_845859_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDN6"/>
    <dbReference type="OrthoDB" id="43767at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="36710" checksum="D5000724984818AF" modified="2009-02-10" version="1">MRSIYELLHLNPSRAAFLHLVLLGIPHRFGLLTTGWGNHYLPSELFPEPCSVFADGACNESELFTLRDSGVRFILYYELAWVVWFVMRKNAANIVAFHKILVGSSMASLLIMSWIQNYFHPSPNSPEFSPSFYTNLVFFHLLAISISLWTLAVHPKPSPGAMKWSIPANSIFCGASFTLLGDVGILTRTIASATKCIQVVNFFAATAGCQMLLEEGGVENVYAMKRSATKTVKLCVFLAAFYTTLHGTLLLRMRVFLTMPQLRAVCLYKLVVNLVLPFLWLPEMSSVLSIDHRIPFAIRGVLTLSYLFGYLLAGQAEGVSRILTAEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDX3</accession>
    <name>B7GDX3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_52709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185332.1">
        <property type="nucleotide sequence ID" value="XM_002185296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDX3"/>
    <dbReference type="STRING" id="556484.B7GDX3"/>
    <dbReference type="PaxDb" id="2850-Phatr52709"/>
    <dbReference type="GeneID" id="7199194"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52709"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237521_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDX3"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="19823" checksum="2304669E1B649D64" modified="2009-02-10" version="1" fragment="single">DLISAFVHCHSNYFVIRTVQADQIIVDQSGVAKLGGLYRGTKKDDRKKDDEDVSANPYAAPEILLGSPKFTMESDIWALGCLLAQLLLSKPLFVGKDRVSLLTAQYKIVGTPSKKNFLEAAKFPYYFKPAKMYKRGVDRALGHMLKNQGETHTKAINLIASMLHLDPSQRCTAAEALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE76</accession>
    <name>B7GE76_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_6457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185389.1">
        <property type="nucleotide sequence ID" value="XM_002185353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE76"/>
    <dbReference type="FunCoup" id="B7GE76">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GE76"/>
    <dbReference type="PaxDb" id="2850-Phatr6457"/>
    <dbReference type="GeneID" id="7199270"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6457"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574248_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE76"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="196" mass="22060" checksum="100FEC88730D2A66" modified="2009-02-10" version="1" fragment="single">VLFVLGGPGAGKGTQSELLQEHYPILHLSAGELLRQEVKKVDSPHAALIESCLVAGQIVPVEISLQLLQNAMRQAKGSQLLFLVDGFPRNEDNLSGWCRLMKNVAMLWSVLVYQCPLDVLEARILERAKISGRSDDNLESVQKRFRTFEKDTVPVIDNLRQVSSQNKMPQWSVEDIRGDQDLEAVWQESQKILNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEH5</accession>
    <name>B7GEH5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185524.1">
        <property type="nucleotide sequence ID" value="XM_002185488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEH5"/>
    <dbReference type="PaxDb" id="2850-Phatr41541"/>
    <dbReference type="GeneID" id="7199353"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41541"/>
    <dbReference type="eggNOG" id="ENOG502SH0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1753271_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEH5"/>
    <dbReference type="OrthoDB" id="204729at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856089" evidence="1">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="149" mass="15632" checksum="5BA1757C1C394C0E" modified="2009-02-10" version="1">MRRTVPIWYALLWPLVLLQIHSSTQAWSAPTCTRRTLLHSWTMAGVAVAGGSNPAHAAADCYADCFQNCKAIAPKDLGYCKDSCRDYCAQPDRRDGLSGSVSSAGGEVGLLGGGFPGSGTVVKGQDKPPSVTLPGLDFSSGIGKKLIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEM4</accession>
    <name>B7GEM4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185573.1">
        <property type="nucleotide sequence ID" value="XM_002185537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEM4"/>
    <dbReference type="PaxDb" id="2850-Phatr41593"/>
    <dbReference type="GeneID" id="7199420"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41593"/>
    <dbReference type="HOGENOM" id="CLU_1879468_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEM4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853207" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
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        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14714" checksum="B228076A6336DFE1" modified="2009-02-10" version="1">MVCIVTLTAVALATVSAFSRTTTSKTCGPERSRNGLFPPIPIGGQHFRGKTNERGRRLALGTDSDLAPAMYNFSGDRHNVVRSPAIAPLYKCEHQDQGQVQDKDDNDGTNKTPPPSKTESNGSSPSDRDSVTRKQQ</sequence>
</entry>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002185578.1">
        <property type="nucleotide sequence ID" value="XM_002185542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEN4"/>
    <dbReference type="PaxDb" id="2850-Phatr41604"/>
    <dbReference type="GeneID" id="7199443"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41604"/>
    <dbReference type="HOGENOM" id="CLU_1135385_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEN4"/>
    <dbReference type="OMA" id="QPLYCTI"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="245" mass="25892" checksum="74901ADAA9DBF284" modified="2009-02-10" version="1">MKLILLCLLAAIALETTVAKDFSSFVHVRSSKRKRNESLSNNESRGTPLEAPKPNLWVDLWDAENELQRILQEASMTSMSFMSISPTPPSPSPPTPEIETTPAPMDPSPVAEPTMAPMDPSPVTAPTLPMPTPLSDEPSLVPSEPVDGVPTSMPLDEIETSAPVAPLPTTEVPTSAPAAEIETSPPSEVTPQPVASPTTDLPTGVPMALIETQPPTDITSDVPSDIPSEIPLTDSTELPTSQPVV</sequence>
</entry>
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    <accession>B7GES9</accession>
    <name>B7GES9_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
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                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
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                <person name="Maheswari U."/>
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                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
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                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
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                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
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                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
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                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="pti:PHATRDRAFT_50642"/>
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        <property type="component" value="Chromosome 33"/>
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        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
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        <property type="entry name" value="PqiA-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34730">
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
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    <feature type="chain" id="PRO_5002853211" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1498" mass="163553" checksum="96621EAD4268E521" modified="2009-02-10" version="1">MRQQRLTFRIAAYVACVFFSCFSSSRLAAAAELAGTGNHAVSEDFPETLHSSGASPLTLSSRARSDDFRSLALGDFDALNALYGNTSFTLPGTTVDTDVGGFTLSLSFANIVCRDFNLGDIRLTPVENITTAATTIRSTLQLVDVDIVCSADYRYRYILGTNGGGRADIYTRDNSVSSQIVLRSPDLARFAPDEFILENCATTVNVFDLDFNGGGVVNIVGNILNALDKVLRNVVEREISDFLCQALQDVDDDVAALLGRLTTLLGPYLGDSPDGNGNDSVAVGALQAERDLVVPSDVTLLNFQEPSTQFANVIDLLVEQVGGYFGNTNTGAGTLNINALLRDQILDDNGALVVDLTKLGDFGSGNLLQASNEILGSIAVKIETATVIGLDSFSRFDDLSQIGNFTFQTGFAIEDIRLEIQMELRLQPPASTQSLVEVVQVEIPLDRVDASTSLLLAIDQGRLGSLPLGSLLNDDSVVNCLLSAVFDLQVTSLSIQPALSVGLPTVRGFATPGLQRVVGTAVEIVYDAFYQTLVVALNNFVQTTAIEFLDDAVQGLRNSTTCLTKARGSETALIDFRDLLLSAEESEAYGGNGTNPYGSLGVVVKSLIDDELVANDASGVPKMNNFIIKPLTEQQSGIAGTFLLAQEFLAFDQRISFNGLDAKVRFRIADLRVENLDTIREPLALLDPLTNEASRINNTLSMGTPSTPLRISVLLQIGVEGAGTTILNKVNIGVELSSVSVVTKLLARIVERDFLSFPIEDMLNIDCWLATVQTPSLSAQGVRNEDSMVSLGLEDLKLLIGDMNFTVDCIECTSPQVLQIGELLRTPQGQTDAATSAQNVVDYLVSLTQGDNSFLQSRIDRLLVESAKRCPHSPSFSSETGSLQYEAFEVNLKEDSMSFLLGVLVAAGVSVGGTILLTILVKVLVARRNRKWLQSLPSSRALAIYDEQQKHRDFEESIDKRTSSMFRSGQVPLVIRWLVPVFILGNIGMFLSGHLSVGGSVRIYIQIAGERLVFDDFYSFSVAQSAIELWDAGGKELAILILIFSGVWPYTKQILTFLLWFAPPTRVSVSTRGTWLLWLDALAKWSMIDVFVMIISIVAFRVSIRSPSQSFLPDDLYRVDLAVVPVWGLYANLTAQLLSQLSSHVIIHYHRRVERKAQNEVKDEPNESLIENGTKEFESEASWTLKDVPLKSSTTEMTDDDGTTQDEAVEALRSHAFGRPHRGEAEKLHVRRGVNILVVVVAVVLTVMLLLGSLLPSFSFDVQGLAGVAVEAGRNFEQAKDEHSIISIAQLLMDQARFVDTAKDYIGTTSIAVLLVLTVLIVPVLQTCALVVQWFYPMTHGTRRRVESVVEVLRAWQYMEVYVISIVVGAWQLPEVSSFLIGSACDGLQSTFAELVFYGFIEAEDAQCFKVDAAISSGSYVLIAAAVLLAVMNTFICKAVGQVEYFSKYRELFAAHGSLHRKELALEEREPVPVDDINAVPVLFTDRFRWLLRTQKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3W5</accession>
    <name>B7S3W5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_bd1265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999278">
        <property type="protein sequence ID" value="EEC42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176255.1">
        <property type="nucleotide sequence ID" value="XM_002176219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3W5"/>
    <dbReference type="STRING" id="556484.B7S3W5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1265"/>
    <dbReference type="GeneID" id="7205078"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1265"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002996_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3W5"/>
    <dbReference type="OrthoDB" id="432756at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="510"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="829"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="128660" checksum="91752920F94930BE" modified="2009-02-10" version="1">MNVNDFNKDYSDDDSVSVDLSSTGTNTESDRQAKSDERDETKEVQRLAASETAHIRFWRLVVVSLLLISGAVLSTFTYVFLNGEEKDDYVDAYYLFANTVRDITRFRAGNMFEAYQGLGETLTAHATNMNLTFPFVSLPMFEVAGRHTLAQSRNELLFFAPFVAGDRKEEWEQYAVEHQGWLDEGRKIRLEADQTLQEILIYRHWGVTIWQTSPVPFTSSLQNFNVRSFENTEFVMDTMRLLKNSVLTWVEDASRTSGAVWNEKDHDAFHAQFVTSTGSESPHDRPHTSIYTPIFEQLGNRNSNIVGFLAGITAFDAYLADLLPDKPYCIFSYELTGNRALYLGDGDRHETAFNQYEVVVPFNAYRDPELAANTDGHCRYSLHIYPSQQFAQGYKSSLPIVFTSLVAATFFLMALTFLVYDRFVHRRNIKVVNAAARSNAIVSSLFPSNVRDRLFEDAKARSDVNQAAHSRLKTFLHNGDSSDTAITDENAHHSDFFKTKPIAELFPHTTIMFADISGFTAWSSSREPAQVFQLLETLYHSFDETAKKRRVFKVETVGDCYVAVAGLPDPRKDHAVVMARFAKDCMHQMHSLTRKLEVSLGPDTADLSLRIGLHSGPVTAGVLRGERSRFQLFGDTMNTAARMESNGIRGRIQISQETSDLLADAGKTQWFVAREDTIVAKGKGELNTFWLSVGDVGKGRSTTDTTHSSDDVFAPNNYNSSVALDGLMTTSAESDQQVYNLVSNKTSRLIDWNVDVLSRLIKQIVARRKASKVPKKDSSKQYFCPGDNRGAGTTVLDEVTEILALPEFDADAARRQQDPENIELDDSITSQLQQYVSNVSAMYRNNPFHNFEHASHVTMSVVKLLSRIVAPVDVVVSDGKNQKRSFASKLHDHTYGITSDPLTQFACVFSALIHDVDHSGVPNAQLVKENSKIATFYQGKSVAEQNSVDLAWDLLLDDSFKDLRAAIFATDVEKARFRQLVVNSVMATDIMDPDLKAIRNARWEKAFSAFPNMQEDLKDVTNRKATIVIEHLIQASDVAHTMQHWHIYRKWNERLFLELYQAYIAGRAEKSPETFWYKGELGFFDFYIIPLAMKLKECGVFGVSSDEYLNYAMRNRKEWEDRGQEVVREMMEKIKGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3W6</accession>
    <name>B7S3W6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_bd1623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999278">
        <property type="protein sequence ID" value="EEC42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176256.1">
        <property type="nucleotide sequence ID" value="XM_002176220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3W6"/>
    <dbReference type="STRING" id="556484.B7S3W6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1623"/>
    <dbReference type="GeneID" id="7204908"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1623"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002996_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3W6"/>
    <dbReference type="OrthoDB" id="432756at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="546"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="865"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133036" checksum="7F9FCD9B028D5E84" modified="2009-02-10" version="1">MNLRSTRNDFRDDGSVSVDLSSTGTNTESDPQFKPDERDETKEVQRLASSETAHIRFWRLVVVALLLVSGAVLSTFTYVFLNGEEKDDYVDAYFLFANTIRDITRFRAENMFEAFQSLGESITAHAIDQNLTFPFVSLPMFEVAGRHALSQSRTEIVFYTPFVTGDEKEAWERYAWENQGWLEESRKIRLDSDKTLQGTSFIEATIPSQIFESTTETAANVDISPPGRDFYSPIWQSSPVPFFPSLQNFNLRSFENTEFVMKTMRLLKDSVMSWVEDASLISGSVWNEKDHDAFHAQFVTGSPDESTSLRPHATIYNPVHEQLGNRDSEIVGFVTGVIAFDAYLADLLPDTVRGIYSVLRNTCGQQFSYELTGNRAVYLGDGDRHETAFNQYEVVVPFNAYRDPELAANTDGHCRYSLHIYPSQQFAQGYKSSLPIVFTSLVAATFFLMALTFLVYDRFVHRRNIKVVNAAARSNAIVSSLFPSNVRDRLFEDAKARSDVNQAAHSRLKTFLHNGDSSDTAITDDNAHHSDFFKTKPIAELFPHTTIMFADISGFTAWSSSREPAQVFQLLETLYHSFDETAKKRRVFKVETVGDCYVAVAGLPDPRKDHAVVMARFAKDCMHQMHSLTRKLEVSLGPDTADLSLRIGLHSGPVTAGVLRGERSRFQLFGDTMNTAARMESNGIRGRIQISQETSDLLADAGKTQWFVAREDTIVAKGKGELNTFWLSVGDVGKGRSTTDTTHSSDDVFAPNNYNSSVALDGLMTTSAESDQQVYNLVSNKTSRLIDWNVDVLSRLIKQIVARRKASKVPKKDSSKQYFCPGDNRGAGTTVLDEVTEILALPEFDADAARRQQDPENIELDDSIMSQLQQYVSNVSAMYRNNPFHNFEHASHVTMSVVKLLSRIVAPVDVVVSDGKNQKRSFASKLHDHTYGITSDPLTQFACVFSALIHDVDHSGVPNAQLVKENSKIATFYQGKSVAEQNSVDLAWDLLLDDSFKDLRAAIFATDVEKARFRQLVVNSVMATDIMDPDLKAIRNARWEKAFSASPNMQEDLKDMTNRKATIVIEHLIQASDVAHTMQHWHIYRKWNERLFLELYQAYIAGRAEKSPETFWYKGELGFFDFYIIPLAMKLKECGVFGVSSDEYLNYAMRNRKEWEDRGQEVVREMMEKIKGRVKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4C1</accession>
    <name>B7S4C1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_bd955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176367.1">
        <property type="nucleotide sequence ID" value="XM_002176331.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B7S4C1">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7S4C1"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft955"/>
    <dbReference type="GeneID" id="7204977"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd955"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S4C1"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="362"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1361"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1374"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1390"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1412"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1674" mass="185022" checksum="056774752CA4EE02" modified="2009-02-10" version="1">MVLAAGPNNPKSAIVRRQIEKVQFGFYNDDDVRARSVVEITSSQAFDPTNSPLPNGLYDVRLGPLKDSEPPCPTCALRASHCPGHFGHIELAVPVYHPLLFPDLLQLLRIKCFACHKLKAPSRTLATLRAKFHLLYRHDLTRLTALDRELLVAIRLGRTSGEDRAENSTAKIRSAKDVADALDKVLRSHQPPTDSTSPSTTKLNSFERNLRKELAKAVLTACKGVKRCAHCGAYNPKIRQDSFNKLFQGALSATSLRANSVENVQFTSALIQASNATSDRATNYDSDDTDRGENTMSGNEDSDSEDDEDDDEVANGTKPKKSDMFMHAGEVQAQIKRTWQTDPFLLHCVFGGSSQSLQDGYQLFFLQAVPVPPSRFRPAMYLNGMAVEHSQTSYLSQMIRFNESIRESFAASDEPRAYSGWIDLQTAVNCFMDSAKDPSATPTNLVAPGIKQILERKEGLFRKNMMGKRVDYACRSVISPDPYIGTNEIGLPRYFATVLTYPTPVTDLNVKEMRALVERGPHNYPGARWVELQGKRVDLGKMNTQKREAIAAQLLTYLKRGGMPAIVGRQLRDGDYVLMNRQPTLHKPGIMAHRVRILHNPTQKTIRMHYANCNTYNADFDGDEMNCHFPQSDLARAEAQYIARTDLQYIVPTDGTPLRGLIQDHVVGGVKLTKRDTFFFKWEVQQLLFAALASLKGLEIIRSGTNIELVPPALVRPRELWTGKQVITIILNHLRKGSDRDSEKMSNLPGLSTSRKSKTPDTAFGAEQEEHLVLILDGELLRGVLDKAAFGATDFSLVHAVYEAYGPEKAGLLLNMFGRLFTAYIQYFAGHSCRMEDLILTSASDISRRMLVQKSYNIGARAAKAWADSEGGKAASTAAKIGQLLSGTEGSTNFAALDGFMQSQLNPLSSAIVKKCLPDGLAVPFPYNTFGLMTTTGAKGSIVNQSQVTCALGQQALEGRRVPRLSSGRTLPSFAPYDPNPRADGFVMDRFLTGIRPQEYYFHCMAGREGLVDTAVKTSRSGYLQRCLMKHLEELKICYDYTVRNAEGSVVQFLYGEDGLDPTKASYLDCSEKSFEYIARNKESLERQNTALPFSSIALAAADATRHVELENNQNLIAVADPILSTPARGHLLGSSGACVSERVAGATHNALNDPEMMRVLKQINVSDADLGVLIGAKYSSSVCAPGEAVGSIAAQSVGEPSTQMTLNTFHLAGAGANVTLGIPRLREIIMTASRDLKTPTMSVPLDDSVTEKQALRLTRDFTKLTLMELVASDRGVTVTEKLEKADNGMWSRAYYVTIKFHPAERIKEAFGLDIHDIAKVAAKNFVPLLSQNMKKELKRAAVEGDNAVIEVQGGDSRVYIKSRDQDERDADEIEIKEAPQARNGRDELNDNDQDDEEDDENAEEDGADAVRYSDRRKESISYEDDDDQDDAETESMTGEHSPRSDSGIVNDLSSNTVVREKEASDWTLRAKEDELIVHERRNVIVLQPLRIDPAARPLLMVGLVEGAAATTLVRSKRMIDQGFVNNEEGRGRCLQTAGVNFEEMYKLECVDHNKLLSNDIWAIRCAYGVEAARSSIVQQIRGVFGAYGIEVDPRHLSLIADYMTFDGGYKAMNRIGMEETSSTLLQMSFETTLHFLRQAALVEDMDEMQSPSANIVVGRPIRHGTGAFTVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3G3</accession>
    <name>B5Y3G3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATR_21006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185837.1">
        <property type="nucleotide sequence ID" value="XM_002185801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3G3"/>
    <dbReference type="STRING" id="556484.B5Y3G3"/>
    <dbReference type="PaxDb" id="2850-Phatr21006"/>
    <dbReference type="GeneID" id="7204601"/>
    <dbReference type="KEGG" id="pti:PHATR_21006"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_37_4_1"/>
    <dbReference type="InParanoid" id="B5Y3G3"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
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            <end position="363"/>
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        <location>
            <begin position="364"/>
            <end position="397"/>
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    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="431"/>
            <end position="466"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="466"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    <sequence length="466" mass="53585" checksum="F99EE59C9C596F51" modified="2008-11-25" version="1" fragment="single">MDELPITDPSIHANLLLESKEDVFKKYSVVQVLGNGSMGTVSKTREHNSQDYIYALKSIILDRVSSVFLDELRNEILILRSLDHPNIVKAHEVYYTRKQIYLVLELCDGGDLYTRSPYSERESARILQQILSAVRYMHDHGIVHRDLKFENIMFENNSPSARVKIIDFGLSKKFLGKPSYMTERVGTVYTMAPQVLQGVYSSQADLWSAGVIAYMLLSASKPFYHKRRRKMIDQIMRADFGYNAPVWKQISESAQDFVSRLLVVDPKKRLNAEKALDHSWIVNRERLPDETPSEDLLAAVDDCLVNYRQTSELKKLALNMIAHRSTAEEIMQLRKVFDSYDTSNDGIITFDEFKAALHKMKYPDEIVQEVFSSIDVNRNGHIQYTEFIASTVLAQGHIAEDRVAVAFDRLDSDDTGFISKKNLQNALGKEYTPELVENIMEEVDKDRDGKISYTEFLQYFRKETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3I8</accession>
    <name>B5Y3I8_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PHATR_46705</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grimwood J."/>
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                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 11"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838754" evidence="1">
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            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="156" mass="16783" checksum="EC909B7292A80FC6" modified="2008-11-25" version="1">MKLSCLFVSSIAFLLSKATVVVAQQSGVQVGDTVTAEGFIMDYFCIFDEVLLDNPSVRTLEGPDQHSVHCLVDISVCRESAYEILGDPVDGEILYTRDLRVDEAGKMMLIDAAREEPEAAAEPSPPAATSAVTITQSSHWVFKILATGALSVCLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Y6</accession>
    <name>B5Y3Y6_PHATC</name>
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        <submittedName>
            <fullName evidence="3">NF-X1-like transcription factor</fullName>
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        <name evidence="3" type="primary">NLTF</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
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                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vyverman W."/>
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                <person name="Wyrwicz L.S."/>
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                <person name="Armbrust E.V."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="7204697"/>
    <dbReference type="KEGG" id="pti:PHATR_36891"/>
    <dbReference type="eggNOG" id="ENOG502SGKQ">
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    <dbReference type="HOGENOM" id="CLU_320431_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Y6"/>
    <dbReference type="OMA" id="FVHEYSD"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom"/>
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        <property type="entry name" value="R3H_dom_sf"/>
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    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        <location>
            <begin position="41"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="123"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
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            <end position="906"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="906" mass="100401" checksum="1F6D734ABFCF6014" modified="2008-11-25" version="1">MRQAAIDRASTTMLAPSHVIRSSPVPTSTASDGAVALPNGGVNNDSHATSAREATTKSKRRRNNRTGKNDTASNKNSTLKEKAEKSKSAIAVQSGGEAEDRKPSVNRPIASSKGKKSRKRSAKKPTPTSIDNGSNDAPEMEGSQKTPSSSNAKPQEQGKKKPNRKRNARKKYPWRQHIPAESVDPITLDSLQSLTYPPFALVAEAPFDPVDVWPIPEVNEEVSKLSVVESEEERHRRVLEEQWGDKIKADDSVDEAHAKLVKPKSRHYHLYDGRALAYWMAASNQFIDPLNRRDITRDELVNLDYYLKKHGFHDLNVTEAYDTKGVTISTAGAAGNTAAGRATILQQEASVLLNSLFGRTSVSRSTQRDHNTGGASNPLMAQYQAYEGIQGEQPGTSQHHRNSNVTQEGSSSRVGNNGPGTYPYSETDAGVYGDLGGILIIDDDLNPGLRGAAAEFVPSTNPARNNGSSNANILWSASHIANRYSHASRVEQHEFPSLAPAAVPTASYTTKESLKKKRLPKVKTLNKIATAVKKTEPEELRRQWEAREEARRKAMMSTLRFGSDPSWNTLEEMEVPTSITTTRDGSPSETHLERNRAFAEALGVTPVTQRESVYTGWARPVLHKMELGEFGDELNVTIFPDALIMEARERMQLLSKIEKKWKGFLIDDTAASLPLSRMDRPTRAFIHLYSDYWKLHTESFDPEPNRYIHCVKLRDTAAPYPLLSDAARNWRGPRPLLQNSVESDRASLQTAGQSTGRDLSRSGERVPLHLKPRSTDTESPLIAGGISIGGACTHTLNGDLVPTSRFAALACETERPKLDLQKRTLPLEMPPFQPEEKGFNVSELSQKQRERMEEKSQKEREKSEQQRRLLAQAFASDDEGDGVMDVDDDSWQEPEAEYQSSNEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Z4</accession>
    <name>B5Y3Z4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_36899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185918.1">
        <property type="nucleotide sequence ID" value="XM_002185882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3Z4"/>
    <dbReference type="PaxDb" id="2850-Phatr36899"/>
    <dbReference type="GeneID" id="7204701"/>
    <dbReference type="KEGG" id="pti:PHATR_36899"/>
    <dbReference type="eggNOG" id="KOG3945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1589616_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Z4"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="156" mass="17138" checksum="61FD02E7724FD288" modified="2008-11-25" version="1">MYSEIHFVDILDMPMKSGSPFDTNFPVSSDHLTLWPSDIVAPTREHVGSALDARNHNTLHATVDTLLWQSLASVMLPGATINMVVKASRLIVQKSPLAVPVLVSQWLPTAMGLGSIPLIVQPIDNGVDYILDRSTRQWWTVVGASTEVHVVDQKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y405</accession>
    <name>B5Y405_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_13361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185755.1">
        <property type="nucleotide sequence ID" value="XM_002185719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y405"/>
    <dbReference type="FunCoup" id="B5Y405">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y405"/>
    <dbReference type="PaxDb" id="2850-Phatr13361"/>
    <dbReference type="GeneID" id="7204713"/>
    <dbReference type="KEGG" id="pti:PHATR_13361"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="InParanoid" id="B5Y405"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44051" checksum="B466E5B6655043A2" modified="2008-11-25" version="1" fragment="single">SHRKFEAPRHGSLGFLPKKRTKYHSGRIRSFPRDDAAEQPHLTAFRGYKAGMTHVVRGVDRPGALMHKREVVDAVSIVETPPMVVVGVVGYVETPSGLRTLTTVFTEHLSEEFKRRCYKNWYNSKKKAYTKYALKYQKDGGKDIENELERIKKFCSVVRVIAHSQVKKLNLRIKKAHIMEIQVNGGDTAAKVDFAKNLFEKEVTVDSIFAKDEQIDVLGVTRGHGYEGVTTRWGVSRLPRKTHRGLRKVACIGSWHPARVSTTVPRAGQNGYFHRTEMNKKVYRVGKKGDEASCQTDADLTKKSITPMGGFVHYGEVKEDWLMLKGAIVGVKKRPLILRKSLMKHSSRKHLEKIDIKFIDTSSKLGHGRFQTAEEKAKFLGPLASKQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y408</accession>
    <name>B5Y408_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Semialdehyde dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_36913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185924.1">
        <property type="nucleotide sequence ID" value="XM_002185888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y408"/>
    <dbReference type="STRING" id="556484.B5Y408"/>
    <dbReference type="PaxDb" id="2850-Phatr36913"/>
    <dbReference type="GeneID" id="7204421"/>
    <dbReference type="KEGG" id="pti:PHATR_36913"/>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077118_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y408"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23935">
        <property type="entry name" value="AGPR_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17896">
        <property type="entry name" value="AGPR_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01110">
        <property type="entry name" value="ArgC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010136">
        <property type="entry name" value="AGPR_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01851">
        <property type="entry name" value="argC_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841133" description="Semialdehyde dehydrogenase NAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="38804" checksum="FAE6C2EB7A74D53E" modified="2008-11-25" version="1">MKLLFSLAVFLTTLGSTTAFVQKPTSQLFRASSSLWAKKKVFIDGEAGTTGLQVRERLAQREDLEIISIPDELRKDDATRKKLINEADAVILCLPDAASKEAASWVEADNDRTVLIDASTAFRVDDSWDYGFPELSKEQRTAIGKSKRISNPGCYPTGFIGLTRPLVDAGILPEGTALTVNAISGYSGGGKALMNVFENEAHEPWGAYGLSLKHKHTPEMAKYSKLNKQPIFQPAVGTFDQGMVVSVPVHYSWMTEGVSGTKIHDALKQHYEGSKFVEIMPLGEEAVKESGLLERGAFLAPDTLKNTNKLQLFVFANDDDGTCLLMARLDNLGKGASGAAVQNLNLSLGFEETTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y486</accession>
    <name>B5Y486_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_36995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185964.1">
        <property type="nucleotide sequence ID" value="XM_002185928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y486"/>
    <dbReference type="SMR" id="B5Y486"/>
    <dbReference type="STRING" id="556484.B5Y486"/>
    <dbReference type="PaxDb" id="2850-Phatr36995"/>
    <dbReference type="GeneID" id="7204754"/>
    <dbReference type="KEGG" id="pti:PHATR_36995"/>
    <dbReference type="eggNOG" id="KOG3201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646362_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y486"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="425" mass="47966" checksum="15A58B043FC8E087" modified="2008-11-25" version="1">MNSNEKSERAKKRWRLLRRALTKQTVEKTTGFPGYCLISGTITASDDDSLLGALSYIDYTTNVVQQIESSLLASLALNTSLRQIIFSFDHESLPLGRPPNLIELSQSLLSSCDLTSCEVESLPKEADHTESSALRISFEPSTASLCFAIKSYTSPTVAGVTLALTRERVRLQISLDELTTHHTTSIDNTGNICVWDCETTLAWAVLEQLENILGNLGRSVVVTELGSGMAGLAALSLCRSLPPCSTIYVTDGHINSIQNNMVNLRLMTVAELRPSTVDVFCQKLKWSLEEDQDKLDLPEEADLVLLSDCAHFEHYHGELLWTLIRATKVDGQVWMCHPERGNSLWRFLQLIDSVNDSASYGPLLRIVYWNHDLLDERHQTFLERHLDTYDPNVHRPRIYRLQKLRKNTEIDRAAIKLHIQKRDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y493</accession>
    <name>B5Y493_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-sulfoquinovose synthase, plastid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SQD1</name>
        <name evidence="4" type="ORF">PHATR_21201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185968.1">
        <property type="nucleotide sequence ID" value="XM_002185932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y493"/>
    <dbReference type="SMR" id="B5Y493"/>
    <dbReference type="STRING" id="556484.B5Y493"/>
    <dbReference type="PaxDb" id="2850-Phatr21201"/>
    <dbReference type="GeneID" id="7204758"/>
    <dbReference type="KEGG" id="pti:PHATR_21201"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040971_1_0_1"/>
    <dbReference type="InParanoid" id="B5Y493"/>
    <dbReference type="OMA" id="YGTAGMK"/>
    <dbReference type="OrthoDB" id="494308at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013107591" evidence="2">
        <location>
            <begin position="16"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="456" mass="50245" checksum="3327D2ACB11775DB" modified="2008-11-25" version="1">MKLLIFLSLVTSAHSFVPVLHLSAQSTPSRTKLFAEGANGDSSAASKKKVIVLGGDGFCGWPTSLYLSDQGHEVVIVDNLSRRNIDIELGCDSLTPIRSPEVRCQAWKEVSGKEIRFVNLDVAKEYDLLVDLIKQEKPDSIVHFAEQRAAPYSMKSAKTKRYTVDNNVGGSNNLCCAVIDSEVDAHIIHLGTMGVYGYGTSGGEIPEGYIDVTLPGGRDANILHPAHPGSVYHATKCLDALLWQFYQKNDQLRITDLHQGIVWGTNTPQTALDERLINRFDYDGDYGTVLNRFLMQAAMGVPLTVYGTGGQTRAFIHISDTARCIDLAISNPPTAGDRVEIFNQVAETRRVRDIAELVASMTDVEVNFIPNPRQEAAENDLDVANRKFCNLGLDPITLDTGLFDEVTEIVKKYKSRCDPTKILPASFWNKKRAEECASIDPKSIQLKKDEAEVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4L1</accession>
    <name>B5Y4L1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186311.1">
        <property type="nucleotide sequence ID" value="XM_002186275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4L1"/>
    <dbReference type="PaxDb" id="2850-Phatr33189"/>
    <dbReference type="GeneID" id="7204331"/>
    <dbReference type="KEGG" id="pti:PHATR_33189"/>
    <dbReference type="eggNOG" id="ENOG502SDKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1121923_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4L1"/>
    <dbReference type="OrthoDB" id="38325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="248" mass="27280" checksum="CC8406BB8E7CD1B0" modified="2008-11-25" version="1">MRTPVIDRFFHKALRRGFRNSGSRQFTDIPVLRDAVVHCRGDLPYGSREYVLLPPHVTLYDLEASTSSPNEQNGPGNLKLASLFAHRNIVFGANVVNAENSRHRLTIREACPVLLETALNDASADGEQPQAVSTLYGLCAWVVDGLEGRVVSRALEKLREDDTSFHAVQAMATGVPRPGHSVVGQGTYRDGQAGWEELAKEFVQTAPSDECLLYLNHQAQLVGIEHMASTKVDYLQSAGGAMARFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNX4</accession>
    <name>B7FNX4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177114.1">
        <property type="nucleotide sequence ID" value="XM_002177078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNX4"/>
    <dbReference type="PaxDb" id="2850-Phatr31636"/>
    <dbReference type="GeneID" id="7195975"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31636"/>
    <dbReference type="eggNOG" id="ENOG502SIHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332747_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNX4"/>
    <dbReference type="OrthoDB" id="48213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="858" mass="97283" checksum="DF0E0E25260B9325" modified="2009-02-10" version="1">MDHGAIDEEDNDFVHGNYTSRKFSPMEVETEQDSLVRETADLSSLGRTPLHFRQQMAAARNNAFANTDQEGDCIFLGFYFLPAEFHSFVRFVGHRFAAHKRIEQQAEQAVMDLKPPHQGTFGGSRNPGQFQQDGNSDVNDDKLPKSNINMEALTAQYGQWEPPNFEGLAVPKYHHYNYHDIPNADLLANAWQKNKTYVQSFLQQAQALVERVKLGIFAEYGYSDNNIAESKLESYHRRRDATLGLIVDHFRVINEVAVDEKTKERLSGIAYLNKNAWQGLIRKLLHAIIMHDNFYVVGVGPASTYRGNNFFQSQVMQFHWIMEPVFCKLGVRLISRNMGMDASTTVSTLGGANVYGEADIFWYISDTTARPHRESCGQMDLLHKQAILSGERMPIILTPEPVVLMTDTNGKAWVGNIQPGVNICGKTRISDGHIRLPQNPTCQYVNCVREALEKHLCNHYKSVCWIERKGFVPEDMQEPNVGFQQDYMGVQTHQLEGRKLAMLVLRGLESALKIWKSETDRGLSPLDEKQWHVQDVYESLRESVWTLEQKPGKSAKVPACEEFLNAVDPMMCNAVDPMMCHMALHAYLEWTPLGDNHELLQELYSGVDVVPLQWKTAEEQVNVHMIAIAANATSLSSESDKDIIISGDNQDNDDDAWINSQYDLTTSHSADVDTDTDDVFPRHLIPDCEMQIATSKWTVYNVPLGYCDGSSQSRCNRAIGNRCLLANYNHYKAGILGHAKSGWLEMRIQIREGIILARFDWSVALHNGRRLRLEDLPSDFEFDFSLKIGSVISKFTKSREEFMEWGVALTSDLVVYPLLVDKKMSHEIDESETVSIGIKIYSSAGLDCKLLLTHIYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNX6</accession>
    <name>B7FNX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177115.1">
        <property type="nucleotide sequence ID" value="XM_002177079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNX6"/>
    <dbReference type="PaxDb" id="2850-Phatr42611"/>
    <dbReference type="GeneID" id="7196293"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42611"/>
    <dbReference type="eggNOG" id="ENOG502SR9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_964610_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNX6"/>
    <dbReference type="OrthoDB" id="37026at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31224" checksum="EEEE9B1C5DE4D764" modified="2009-02-10" version="1">MAEHSNGDENSVPTDPNDPRVVRQKAEMLVDEDPLLISQSLTYVTDDGSTLHSFESAPFSYGTIIVRPGSALQLVATANMAFLTTLLPTAACTLITVGFKVQFIIVESILVLLMIAAVPVGAHGTVVGVAIGNLVILAWFWYNLVRSVDVTAEGTLRFWIGNIEVDVPFDKVVSIRRVASSMPCSVFVASQPYRGFLSTPTDGVAIVTTVPSTPFWLWPRSAGKPERTCCFGAFSCPRLTVVFSPSTGGSNFIRTVETEMQNFSAGRFPASRNSSNAVPHAMQPDYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPL9</accession>
    <name>B7FPL9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_9601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176737.1">
        <property type="nucleotide sequence ID" value="XM_002176701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPL9"/>
    <dbReference type="SMR" id="B7FPL9"/>
    <dbReference type="FunCoup" id="B7FPL9">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPL9"/>
    <dbReference type="PaxDb" id="2850-Phatr9601"/>
    <dbReference type="GeneID" id="7196417"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9601"/>
    <dbReference type="eggNOG" id="KOG3174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045864_1_1_1"/>
    <dbReference type="InParanoid" id="B7FPL9"/>
    <dbReference type="OrthoDB" id="46331at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="214" mass="24231" checksum="4D3FA3D96D0CAF9F" modified="2009-02-10" version="1" fragment="single">MSTNLDATEALLKRHQIPFRVLELAEEGEKPFLLCQSNKVGEKYRSPWTNNLYPGGEPDPTDSDEIRLFETKMNHVWDAYKNLYYGHDSIGSVYLFPTDKGSFQGFFGIQKKCSSGSWNSMHLVHVDTPEENMCNYRVESTIMMAIEPETNAKATTKFDISALLSKEVTKNAKVQPSMVGSSHIENIGQLIEAIEIDLRSAIERVHVPKTQEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPQ8</accession>
    <name>B7FPQ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176754.1">
        <property type="nucleotide sequence ID" value="XM_002176718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPQ8"/>
    <dbReference type="STRING" id="556484.B7FPQ8"/>
    <dbReference type="PaxDb" id="2850-Phatr31927"/>
    <dbReference type="GeneID" id="7196434"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31927"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867300_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPQ8"/>
    <dbReference type="OMA" id="HVYETEP"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="321" mass="35108" checksum="B0238663A98239B1" modified="2009-02-10" version="1">MASLPSEYEIDAVLDAALDELDQDDDDDRQRELDESSNGIAVDVSNMAHSATKSNSYQHETPFVGPLPPPRAAGDEGLNETDAILSSMMKELLSANGEDVDAAASEFLGNLIHEIQFETTEAQRTDPAPSPSDGSKQSRSSNPSKSDKESSTTVDEAISTLIEDMAKQAGTDEFGKDDSSDETMLNDLMQGFAGMGEGFDTDAVIDGMMEQLVSKDLMYEPMKQVALKFPSWLKEKKDSITEQEYSNRCKQSKCFERLVHVYETEPTNTGKLMNLMQNVQAYGQPPREIIQEIAPGLEMDVDGMPKLDASGIPTDSDCCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPW4</accession>
    <name>B7FPW4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177286.1">
        <property type="nucleotide sequence ID" value="XM_002177250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPW4"/>
    <dbReference type="STRING" id="556484.B7FPW4"/>
    <dbReference type="PaxDb" id="2850-Phatr42880"/>
    <dbReference type="GeneID" id="7196460"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42880"/>
    <dbReference type="eggNOG" id="ENOG502S9CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1424036_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPW4"/>
    <dbReference type="OMA" id="RVECANA"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF11">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21164" checksum="88C4AF898A7014CE" modified="2009-02-10" version="1">MLAPRKKLWSTPDTVIAKAIAWVPLQPGDLVGDVGCGDGRVLLQWATAFSQTNGSQLSSWVSSRPNESIVSFIGIDVDYERVECANAALRVAREQGHIHPAVQVSFHCTNALDATDLYANVTVFFLYLIPRGLRILHPHLPRTARCILTYMSPLPDRTPIQRELVPVPHQPGAAWPLHLYSNRIDNVARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ68</accession>
    <name>B7FQ68_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176828.1">
        <property type="nucleotide sequence ID" value="XM_002176792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ68"/>
    <dbReference type="PaxDb" id="2850-Phatr42971"/>
    <dbReference type="GeneID" id="7196791"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42971"/>
    <dbReference type="eggNOG" id="ENOG502S726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_910487_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ68"/>
    <dbReference type="OMA" id="TWTWHRV"/>
    <dbReference type="OrthoDB" id="39952at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855290" description="JmjC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="132"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="306" mass="33984" checksum="B16B4D4AE57CB223" modified="2009-02-10" version="1">MNEIKIIITLLAILCVACIAVDVQKHRSNLAGFLEKTYGVHWRTRPLLLQGLWKKEELLDPDRRLSLSGLLNQSLEIPYFSDARIKNSLSPDSKGSVGAIVANISNGGAHKIGTQFIVQTYPDLISEVAPTEIVTELFGDFFKPDYVKGSGPFSIFPALTTVPMFVANGQKTEGFYNKGQPYTPLHCEPIGNVAVQLSGTKEWTLIRPEFSFLVKPSTAPDGRAFFASWASKLEHVPTYSARTNAGDAIWVPTWTWHRVDYVYSPEISIGGSLFHFRTADFARNNPLFAILMIPAILFELVGYSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ87</accession>
    <name>B7FQ87_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_3120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176836.1">
        <property type="nucleotide sequence ID" value="XM_002176800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ87"/>
    <dbReference type="FunCoup" id="B7FQ87">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQ87"/>
    <dbReference type="PaxDb" id="2850-Phatr3120"/>
    <dbReference type="GeneID" id="7196802"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3120"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_73_2_1"/>
    <dbReference type="InParanoid" id="B7FQ87"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000068">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0140">cGMP</keyword>
    <keyword evidence="10" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="241" mass="26455" checksum="879A84923EB22951" modified="2009-02-10" version="1" fragment="single">KSDAAVQFIDSALEDNFIFASLSSTERRLLIDAMMMEQVPAGTVIIKQGETGDFFYVVEEGHVSFAVDNQHVGSTGRGGSFGELALLYNCPRAATCLANTVCRLWKVDQKTFRHMLANNTNTQQKDINDVLRKVPFLAELDDRDLLRISDALTSVTFPEGERIINKGDVGEVFYIIREGSTKVHDIGFGDSTYVDQPLGPGDFFGERALITGDPRVANVTATSSCTCLCLSRDTFEKVLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQR0</accession>
    <name>B7FQR0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176914.1">
        <property type="nucleotide sequence ID" value="XM_002176878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQR0"/>
    <dbReference type="PaxDb" id="2850-Phatr43132"/>
    <dbReference type="GeneID" id="7196744"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43132"/>
    <dbReference type="eggNOG" id="ENOG502SRHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504796_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQR0"/>
    <dbReference type="OrthoDB" id="47482at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="540" mass="58836" checksum="02CEDA3D797BC95B" modified="2009-02-10" version="1">METSRSKAAAAAASMVPFHCVICFEEFTSTDRTPMVLPCGHTFVCAPCTRRLRRCMECREPLFMPATSNGGIRLSNQRVLMPPVTVRQGDRSSPDPSTPPRQQSQFPGPLALPIPKNVVLLSMMEAAGRQKKIDGQQKKEAEDTDSVESGVDSDEEEAEQFDLGAIIRSMATMSGPCGTYAVRERFGLAVLPGDPRRNRSFSGEREADVAEPAREREPFSLTFGQKLQIVDFRDGVAKLARGEGYVVATSSQLVKVGGPLDESCRLEGLLYTVASRGYDLQRALEENKLVVTHLQSQIDAIKLEGPSHPVVGEVPVDELTASRSGDDSDTHPSTPQSVDQSGILQRVLRSPINGNMAVGSPASHDILSDMVEDGDAVYSRSSPGFPSSLDSIDNEEMVRAGMPTIYRRTESAGDLQQFTFGCGSSLLAGAANEFFGESPTPAATQRYSPRTFNNATRPHSQTYHVDQTPSIAPQFTSSFDGINFRTGMSGHRALLSTNPGRENRQRREIRMMSEHRGIGKARGTSRTSPKSLPSFGPRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR35</accession>
    <name>B7FR35_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_17936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176975.1">
        <property type="nucleotide sequence ID" value="XM_002176939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR35"/>
    <dbReference type="FunCoup" id="B7FR35">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FR35"/>
    <dbReference type="PaxDb" id="2850-Phatr17936"/>
    <dbReference type="GeneID" id="7196959"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17936"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="InParanoid" id="B7FR35"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="206" mass="22688" checksum="A5C81E23573A21EC" modified="2009-02-10" version="1">MANFGELVLVLGDVHIPERASKIPAPLKRMLVPNKMQHVICTGNISTEMYEELRTLAPNVHIVAGDFDTTEMVFPETRVVQVGAFRIGVVHGHQVLPWKNQDAAARMRRKLNVDILISGHTHQNEVTLLDESYYHINPGSITGAFSSLTEQVTPSFILLAVQDKKVVCYVYELVNGEVEVSKTDISKSEASQSSSANSSLMASLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR62</accession>
    <name>B7FR62_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_8770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177526.1">
        <property type="nucleotide sequence ID" value="XM_002177490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR62"/>
    <dbReference type="STRING" id="556484.B7FR62"/>
    <dbReference type="PaxDb" id="2850-Phatr8770"/>
    <dbReference type="GeneID" id="7196973"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8770"/>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017595_2_0_1"/>
    <dbReference type="InParanoid" id="B7FR62"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="44826" checksum="477B2A74C985E3ED" modified="2009-02-10" version="1">MDLSSFDKDYILRGLARLYRKKILPLELSSRYGHFHSPPLSPSDFAAPPMILLLGQYSVGKTSFVKYLLGRDFPGIRVGPEPTTDRFTAVLWGQQDKVVPGAALCSQQDRPFTGLSPFGNNFLSRMEGAELNAPILRNITIVDTPGILSGQKQRSRNYDYEAVMKWFAERADLVIVMFDAHKLDISDELKAVMELMIPHLDKIRVVLNKADSISTQQLMRVYGALMWSLGKVMNTPEVCRVYMGSFWDAPLQNTEQAELLQREEMDLLHDIMALPQQAVMRRINELVKRARSVKVHAYIIHYLRKQLPYTFGKREKQRRLIGRLESEFLAAARRYGLPKGDFPALEPMRQALYEIKDLSEFPKLDKKLLREMDKVFSQDIPLLLEKARNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRJ8</accession>
    <name>B7FRJ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome alpha 1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_53939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176558.1">
        <property type="nucleotide sequence ID" value="XM_002176522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRJ8"/>
    <dbReference type="FunCoup" id="B7FRJ8">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FRJ8"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="PaxDb" id="2850-Phatr53939"/>
    <dbReference type="GeneID" id="7196690"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_53939"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="B7FRJ8"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="245" mass="26947" checksum="F432AF275442E1E4" modified="2009-02-10" version="1">MSRDSNYDHHISIFSPQGRLYQMEYCFKAAQSGLTVVAVRGKDSACVVTQKKVPDRLMDPKSVTHIFRLSHKVGCCVTGTMADCKAYIQRARYEAGQWSFDNGYSTPVAVLAKRMADLAQINTQTASMRPLAVIALFIGVDDEKGPVVYKVDCAGHYLPFFATAAGPKEQEAMNFLEKRANDLKEMDTDQTVRTAITCLGHVLGSDFRGSEIEVAQVVGIQGKFQVLSEDQIETHLNAIADDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRS1</accession>
    <name>B7FRS1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177851.1">
        <property type="nucleotide sequence ID" value="XM_002177815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRS1"/>
    <dbReference type="PaxDb" id="2850-Phatr43291"/>
    <dbReference type="GeneID" id="7197595"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43291"/>
    <dbReference type="eggNOG" id="KOG1881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475287_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRS1"/>
    <dbReference type="OMA" id="NESRERQ"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="574" mass="63415" checksum="525C4089666868AB" modified="2009-02-10" version="1">MSGYEAPPWAVKPSVSSGWKLIEIKSGVQVNAYILDQQPCTLLGRAADQVDVVLSHESCSRWHARIAFDAVSENPWLRDLASAHGTIINKQKLPAIACGKTESRATTPGARGVLLYPGDVLQFGASSRIFCVEGPENCSRNSALNKLHRSQRTKPPKDTDDPSSLSSIRVNEHRPGEQDHSPTSHEGPPTTLDLEGPPPATHRADWDRLRAIQYKLDNLQQESERIRAKVDLTDGQTRQLERNESRERQLRGDFATLESELIPKLFPSAKPSATKLSTEAQEFLREDEVDDRTCESMDNGTLELDPTGETEQSLTQKWKTMVLLLQANVTDSTRARQRLSLVEEKLSRLLEAGDEESFFVQNDAKIAKESVDKLESESQHISKSMLEVKRLLHVVNPKLYTDETTGYIGTRTQTRLPPPKTDESDISSFLEDESFVMPPPALPQSSPPPQTNVDSSPAIHERREIEDGTLTTMLLPPPPAKKTRVVGPSMPAPYARSKVAPPLGTLAMLSAATSNHAVVAKSRSRGQSKEKSEKDSAIRKAASMEDGNIDVWQAPKDQDGSGRTKLNAKFAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS59</accession>
    <name>B7FS59_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_43413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177609.1">
        <property type="nucleotide sequence ID" value="XM_002177573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS59"/>
    <dbReference type="PaxDb" id="2850-Phatr43413"/>
    <dbReference type="GeneID" id="7197429"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43413"/>
    <dbReference type="eggNOG" id="ENOG502SYHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1009942_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS59"/>
    <dbReference type="OMA" id="NVEAICW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="31527" checksum="CD257C10CEA245D1" modified="2009-02-10" version="1">MSNEDKSEAELDEMDDSKIFPQRLMEVLGDENNVEAICWLPHGRAFMIRSRSLFSERVMPRFFPRKAKYSSFTRKLNRWNFVRVSSGPELGAYYHEFFLRDKPHLAAQMFCKNARAKLAMANDPNPNVTVPAIGIRPQETLPVASPPQSVALAPSQQEISVAKPQIDATILALLQQQRSKTSLDEKIKSALYPPYAPNNVQLLERQMQILQQDLAQRFLVEQLIRSASQQQQVTQPIPMLQNQQSSNRLLQMRQLMELRLNQRQGRVPQGSRASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSR6</accession>
    <name>B7FSR6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_32830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177712.1">
        <property type="nucleotide sequence ID" value="XM_002177676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSR6"/>
    <dbReference type="FunCoup" id="B7FSR6">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSR6"/>
    <dbReference type="PaxDb" id="2850-Phatr32830"/>
    <dbReference type="GeneID" id="7197466"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32830"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_3_1"/>
    <dbReference type="InParanoid" id="B7FSR6"/>
    <dbReference type="OMA" id="NIEWSED"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="111"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="393" mass="43849" checksum="6E619D08680205FE" modified="2009-02-10" version="1">MKTSKKTITINLTRNDSKIASARGAASKPYSFHGGMTTTNLLFAKAGKPLQDRAETVAFMKVLMGQEQAVDGCNDGTSSAPRPQRPQLSNVHGAGLLLISDIPDSCRNKQGVVVGIDEAGRGSILGPMVYGAAFWNPCDEDRIPNDFNDSKQLSEDKRAMLLHKIMYDTPEMGFAVRVLHASEISRNMLRTESYNLNQMSHDAAAGIIEHLLEAGVQIGACFIDTVGNADHYKRRLQQEFPGIDFTVESKADAKYPPCSAGSVVAKNVRDRMMESFQYSEMSLKRDPKFGSGYPSDPVCKDWMENNQNCKVFGYPDVVRFSWNPAKKALERNAASVLFQADIIDEDEEGEYCIGKKQQQTQMSAFLGKQDATRKRKRYPFFERNRLQVVNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSU3</accession>
    <name>B7FSU3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_18258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178040.1">
        <property type="nucleotide sequence ID" value="XM_002178004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSU3"/>
    <dbReference type="STRING" id="556484.B7FSU3"/>
    <dbReference type="PaxDb" id="2850-Phatr18258"/>
    <dbReference type="GeneID" id="7197481"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18258"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="InParanoid" id="B7FSU3"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="598"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="743" mass="82354" checksum="8CD9604B69F16F20" modified="2009-02-10" version="1">MGALVPPQNVSTSAERICCIHFHPLGKYVGVLHSSSKNIDVYLIRNLQDSSKKRQRRLRRRHEKEKRKTNDGTSKSGQKRGILDDPNSSSDEQGDGALLESSIMDPELMKASDEFEYVTTVHASQKVRGFAFLRNKEKGELARVVCVLSSNALETHMLERKKGSENVSLVLSSKVATLDMHGHPSGIRAVVLSSDDNLVCTISKSVAKIWNVTSRNVIQSVSPTILSSRKGKKLSCYGLCAAFLPGNTHIIVGTREGHLLIIDISAGDVVDSEENAHDGAIWSLDIRRPNASDTSIALATGSADKTVKFWEIESAADDEGGIPIIVLSRTIKMTDDVVAVRYSNLIERSKRMVFVSTLDCTVKVFFDDSLKLFLNLYGHKLPALAVDASDDDILLATSGADKTIKLWGLDFGDTHRTLHGHEDSITDVRFVTRTHNFFSTSKDGTVRYWDGDRFQQILVLKGHCAEVNCLALSRTGAFVLTGAMDRQVRVWERTNDIVFLDEERERALETAFEKVSSRDEGGTAGILDRRSDIDDDEGQHDEPQSEAAVKQSIMSVSGGDRIMDGLEQADTELESFRKGQESWGKRSPNPMLLGLEPAQYVLWILRSIKNSELEQSLLVLSLSHIERLFFYLTNLLRDGQGVELCSRVGIFLIKTHQNQLLASRSLATPICEVRRLTRLRLSEARDMVGYNLAALRMIARVSSNGKKSFLPDDSQSPEDIWAGLGLGSDVAAALKGRSRKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT36</accession>
    <name>B7FT36_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178091.1">
        <property type="nucleotide sequence ID" value="XM_002178055.1"/>
    </dbReference>
    <dbReference type="SMR" id="B7FT36"/>
    <dbReference type="STRING" id="556484.B7FT36"/>
    <dbReference type="PaxDb" id="2850-Phatr43680"/>
    <dbReference type="GeneID" id="7197450"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43680"/>
    <dbReference type="eggNOG" id="KOG1860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239539_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT36"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="3">
        <location>
            <begin position="168"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="3">
        <location>
            <begin position="409"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1458" mass="164273" checksum="017EA6A8BE976750" modified="2009-02-10" version="1">MSGFGSSFGSPAPGGPASGPSLFGASSSTPNNSATAGHTQSNNTGFGASTSPPAFGAPVSFAPTVAFAAPAPALAAPLFGSPTSVFGNRSPAPRSRSTSPIPPINISSLSDRNALRFTGSHNGRSHMPADLQSKSEEAPNYAALRTDPQGGRADLGSAVSMVGTCPYMCPDEELLRREREGDIQLLETPQPGTLHPESWTYRDTVVKRFRRSAADYKLDVPEWVRPPDVLERVCSYLEEWIMEKDRQGPDQRFPQGGVPPSLDVYQFIWDRTRMIRKDFILQNYVGTGGACDARAVRCHERIARWHAMCEHQLSHISEYVSHQSQQNIQELGQTMKTLNQYYDDSLKRSLIEVPDAQGNETRLNLLGQAHGCESNSVQGPNPVDYDGTPLSNDEDTSRVSLRVIGGDVSRSSMHGTAEPEMRGLYILLTIDNDGGMEVLKYAAWLFRERPYIYQSQPVQLAMTIYKAKREFNYARFFSILRSSSTPYLFACIMFKHVQVMRKNAFQIMSKTFGVRSSATEAIYDAYPLRDLMRLLCFEDIEEARNACQHYNITCKEMKIKTSASGTRIEDIVFWRATKFRVPTDAEKGTIVQLRPKKMIKTIESKLNGATRLAVCRGEVSAFGASPTDREFPLVSAQSQNVALKEDTVKRNSGEEVASLAARKQEIERQQQEELEKRQQIERRRLDEERIRHEAEREQRISLELKRQDMESKQREIELRQQQAKERIELERLQKEEVEQQRKLEEEAERKARDEEVRRQLELERLEKTRREELKRLDEEARKREEVEKQRLQREAEEAEARRQEEAARQKKLALEKEKERQQCEEKARLNDVRWREQTEEAKKILLWKRWKQKLPKYLENAEETARMLQHLSPTSSASLKLVKLLHGATTFHSHQPASLLRHKFSYPPDLRMVLENLLNQDTKQINLSSGIAESLSRIWRCSRLDNSCQKCFLFKIGVLCPQSKSIRLQSLSELLKAWLQTVLSFHKIHETSTTFVNVRVVVTDSNHSKMDDCDCVLVVVPVMFSIGEELLRLKGLSSTIGRTVPRVVLGLTDNFDRACVDDMNRRLDDTFSSLSNNITLVNNAELSLEDVRGALHCACEQIAQRITEEAPVVIQRMTPEQVACKCISDAISQSGPTEKRDKIVELAQAALIIMIEEMEDVAAERERAPSWPASEFANDSGRVLHYFGRGEHLPLLWSSTLSLGNVESRLTPMSTVLNGSLPDALEQLLRGAPEQILYECHTLLDKRLFRQCLQQSLFWFRDAIHPCTSESFLYFAPGDVDCIAQATGIRLRNLVERENSICFEANEGKDDVRENDLFAEVIDSPLEFDGEAQLALGSATETPTPPASPEVTKTTPKRALSDASIQPIDSVEAGSFAKQTPGAVPTPQSLSYGTSPKRARQTSVATTSLVAVSSDVMHSRKWTERLEALASGDVMADMIVGQYMLSALVQDAPPLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT42</accession>
    <name>B7FT42_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177773.1">
        <property type="nucleotide sequence ID" value="XM_002177737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT42"/>
    <dbReference type="PaxDb" id="2850-Phatr43686"/>
    <dbReference type="GeneID" id="7196989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43686"/>
    <dbReference type="eggNOG" id="ENOG502S6KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1117565_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT42"/>
    <dbReference type="OrthoDB" id="10054414at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="27790" checksum="7E80E7680A4D760E" modified="2009-02-10" version="1">MAKRDDRNESRPSFHRLERPSKCPSCSRLIRVKTGARLASYLGLCIVAFHCWNTRSFYSKLTENHARGRISDEVEDESGRISLTCIEAVEGLVKGKILLIAIDFDLTIISIHTGGRWKWSADDLVPYVRPEFRCIICECLQKDIHVAVATFSDQVDLISDVLAATVAHDDAAQIPIYGGTANVRGSFEGKRSQLLLAVEHVEAKTGLSLPKEATVLVDDDRANIARAKKDGYKTIFYDPTIPHNKFPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTB9</accession>
    <name>B7FTB9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_43748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177815.1">
        <property type="nucleotide sequence ID" value="XM_002177779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTB9"/>
    <dbReference type="STRING" id="556484.B7FTB9"/>
    <dbReference type="PaxDb" id="2850-Phatr43748"/>
    <dbReference type="GeneID" id="7197268"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43748"/>
    <dbReference type="eggNOG" id="ENOG502S8V2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060049_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTB9"/>
    <dbReference type="OrthoDB" id="3558741at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="64"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="232" mass="26733" checksum="B03A32F35AE0282C" modified="2009-02-10" version="1">MSLTSNFLFSLIWGYGWKVALVAFLYVTSVLVGRIAYPIILRYPWPHPTTSRRICSDKRKIVVLAGSYNPPHLGHLAMIQYLGERYRKVIVVIGVNPSKRYDVTPEERADLTRRMLKRSATSSNVEVHVVKGYIWRHAKREGAEIFFRGIRSWEKDGREERSLQILNTWGPLLLGPLWYPIPTQFLEGKPEYNHISSTLIRDLSSIPNSSVTDLEHLVPKSIVKDVTKLYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTH9</accession>
    <name>B7FTH9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_11032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178419.1">
        <property type="nucleotide sequence ID" value="XM_002178383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTH9"/>
    <dbReference type="FunCoup" id="B7FTH9">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTH9"/>
    <dbReference type="PaxDb" id="2850-Phatr11032"/>
    <dbReference type="GeneID" id="7197987"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11032"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="InParanoid" id="B7FTH9"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="115" mass="13118" checksum="8D99D94E38E99193" modified="2009-02-10" version="1" fragment="single">MKYSQSVTSSRRKNRKAHFGAHSEARRKLMSASLSKELQARHGVRSMAVRKDDEVMVVRGTYKSREGKIIGCFRKKFVIHVERLTREKVTGAQVHVGIPASNVVITKLKLDKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTN0</accession>
    <name>B7FTN0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178445.1">
        <property type="nucleotide sequence ID" value="XM_002178409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTN0"/>
    <dbReference type="PaxDb" id="2850-Phatr44305"/>
    <dbReference type="GeneID" id="7197967"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44305"/>
    <dbReference type="HOGENOM" id="CLU_958005_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTN0"/>
    <dbReference type="OMA" id="DFARTNT"/>
    <dbReference type="OrthoDB" id="43894at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37314">
        <property type="entry name" value="SLR0142 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37314:SF4">
        <property type="entry name" value="UPF0700 TRANSMEMBRANE PROTEIN YOAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852624" evidence="2">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="30161" checksum="8459AE11AEF00425" modified="2009-02-10" version="1">MTTSPARCTLLLVVFAIVTAGVVSDSPLSTDALRSNASLTVTTKSHASFMEALSTYSAPAYDVKELRGGKINMISLQFAITSGILLAFNSGYINGCCLKGTLLNTKQAVAAVTGAYTTSALGLASGNTDQFRTQLTVLASYIGGSTIAGILNPIPVPFQMSSSNGLAFLVASALLWSSSSLAQKGSANILVFCLAATANGIQNSVTSAHTSNLIRTAHFSGISSDIGTFLGQVLRGNRQNLHKLKIFLALAVSFWSGGFLSFFVSDRLGATCLVPSAVLYTTIGLGLILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUP6</accession>
    <name>B7FUP6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_44618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178632.1">
        <property type="nucleotide sequence ID" value="XM_002178596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUP6"/>
    <dbReference type="STRING" id="556484.B7FUP6"/>
    <dbReference type="PaxDb" id="2850-Phatr44618"/>
    <dbReference type="GeneID" id="7197622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44618"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_1"/>
    <dbReference type="InParanoid" id="B7FUP6"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010177">
        <property type="term" value="F:methylthioalkylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07940">
        <property type="entry name" value="DRE_TIM_IPMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000001">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000010">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002086">
        <property type="entry name" value="PRK00915.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF9">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855030" description="2-isopropylmalate synthase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="663" mass="70952" checksum="A28FC327C4C621D9" modified="2009-02-10" version="1">MKFILTASIVVTVWLASSPKTISAFTPINLRNGALKASKVRSSQSPTIRRNGLAAMPEDANNELDTHIVLKQRQPRPAYIPGKIDDPDYVRIFDTTLRDGEQSPGATLTSAEKLEIAQMLAKLGVDVIEAGFPIASPDDFNAVKQIADIVGNDVFEDGYVPVICGLSRANQKDIQTAWDAVKGAKLPRVHTFIATSQIHMETKLNKTPDQVVEIAVEAVKFAKSLGCNDIEFSPEDAGRSDPVFLYRILSEVIVAGATTLNIPDTTGWNMPWEFGDLIKQLRENVKGAENVVFSTHCQNDLGLATANSLSGALNGARQLECTINGIGERAGNASLEEIVMSLALKGATKFSGGPGTGKLFTAVNPVYITPTSKMVSEYTGMACQPHKAIVGANAFQHESGIHQDGMIKNKSTYEIMTPESIGLMRGESQSGAGIVLGKHSGRNAVGTRLRELGYDLDTEKLNAVFVRFKQVAERKKGGLEDEDLEALVSDQAGLSNLLWEVTGLQVATGLSGIPTATVKMLGPDGLERYVACTGTGPVDAVYKAIDQIMGVSVRLEAYQLNSVTEGIEAMATTRVVIAPLEGGPNDSISIHSQTGVSRNRKFSGSGSDTDIITSSARAYVSALNKLLKWNARSREQAREEKTNGSGVGDAELAGNMEVAEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUR0</accession>
    <name>B7FUR0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
            <ecNumber evidence="3">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CMK</name>
        <name evidence="12" type="ORF">PHATRDRAFT_51700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="3"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178363.1">
        <property type="nucleotide sequence ID" value="XM_002178327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUR0"/>
    <dbReference type="FunCoup" id="B7FUR0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUR0"/>
    <dbReference type="PaxDb" id="2850-Phatr51700"/>
    <dbReference type="GeneID" id="7198117"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51700"/>
    <dbReference type="eggNOG" id="ENOG502QT9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237592_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUR0"/>
    <dbReference type="OrthoDB" id="3191556at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527">
        <property type="entry name" value="4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855466" description="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="10">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="11">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="355" mass="38987" checksum="F7833BCC8EE620BD" modified="2009-02-10" version="1">MYFASAHVLFLAALSREAVAFTDNRFPIFNHPSAKVTTTSSLSAYTETNESSRGKISERTLTLFSPCKINLFLRIIRKREDGFHDLASLFQAIGFGDTLELTSIDSDADEFTCNMPGVPVDNSNLVLRAIQLMREKTGEKQSFRANLIKQVPAQAGLGGGSANAATAMWGVNELMGRPASLDQMVEWSGALGSDITFFLSRGTAYCTGRGEIMSSIDPPLPSGTKICIVKIDIGLSTPSVFKALDYDKLSNLNADDVLLPTFLRGIDQVPDSYFVNDLETPAFKCIPELRSLKEELLGVAGFDHVMMSGSGTSIFCLGEPKDNKDFHDRFVSRKGLQVFFSEFISRPEGVWFEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUY5</accession>
    <name>B7FUY5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_11021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178678.1">
        <property type="nucleotide sequence ID" value="XM_002178642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUY5"/>
    <dbReference type="FunCoup" id="B7FUY5">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUY5"/>
    <dbReference type="PaxDb" id="2850-Phatr11021"/>
    <dbReference type="GeneID" id="7197924"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11021"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_1"/>
    <dbReference type="InParanoid" id="B7FUY5"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="34855" checksum="EDD78F1401A222E1" modified="2009-02-10" version="1">MNLFTAVNDAMRVALRTDETAIVFGEDVAFGGVFRCSHNLREEFGADRVFNTPLSENGIAGFAVGYAATGGTAIGEIQFADYIFPAFDQIVNELAKFRYRSGNQWNAGGVTLRAPCGAVGHGGHYHSQSPEAYLAHTPGIRVVMPRGPKAAKGLLLASIRSRDPVVFLEPKALYRAAVEDVPVGDYEIELGKAEILRPGEDVTVVGWGGQLRVLAKACALAAELGIDCELIDLQSILPWDFETVAASVSKTGKLVVSHEAPITCGFGAEVAATVADRCFWNLEAPIKRVCGYDTPFPLIYEKYYIPDELKNLEAIKTVVEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVA6</accession>
    <name>B7FVA6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_34600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179106.1">
        <property type="nucleotide sequence ID" value="XM_002179070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVA6"/>
    <dbReference type="PaxDb" id="2850-Phatr34600"/>
    <dbReference type="GeneID" id="7199681"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34600"/>
    <dbReference type="InParanoid" id="B7FVA6"/>
    <dbReference type="OrthoDB" id="509720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="703" mass="79664" checksum="0E915604F90C0E6F" modified="2009-02-10" version="1">MPSASHRRSTMQTTSSTVTTSMITTTGNDHDEEGIFVFVVAGNPLRARSKPSTDSHDRTRLEFQPGELVSADLIHRPNSNSINTDSQLFFLRLTDRAGWVYGTTIATLQPVAIESGLWCSYIMCAQFLRRHPVQSADLSYETHYMAYQKVYTDARVVHPTTSVVYYRVQGTRGWLADRDEHWNQDKHESPTTAIHAMTSKAVPRNQIVMVDWILQHQHRDTENEDDGPYLRLADGSGWLFEYKSGNCTMQSVPVKLGTWEIQILNPPVGVGVRTYPQDTQDRVTGLILETDETVQCDCAIESQGVIFYRLTNTGGWVPDRMHNEPLLEILSLSYATSNERRNSPWTVDFVRGIVATVPGTREYSYQSQTNVLRLQTMDQVFVHVYLDTRTVGAILPRETRQRCQRDCRAMDLLEILTKTPQVWTHEWDNGDESKDDDYYGISTSVSEIHEEEEWQCRQDLLQCDSDLQQIQKQRQKLIQAIETYDQNRIEMLKKEAEKDDKIYNPIVHTEAVKEAHLPPMKPLPASSPNIPNVQHVKLKSLRSGSGRSYDHTNGVTIVGMPHPIESGSLTKPGRNLAVASRSSSTKSSKPHQNRPVVDVLIEDNSNVQAGLFTSPMYACTSSPSSAAPTSSNRGERSLSRLSRARKRPGRGMFSCGECNKRFESIEKRDRHCIESHGTYCDRCDRVFKSFAALDQHVQLEGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWC8</accession>
    <name>B7FWC8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_34672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179138.1">
        <property type="nucleotide sequence ID" value="XM_002179102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWC8"/>
    <dbReference type="STRING" id="556484.B7FWC8"/>
    <dbReference type="PaxDb" id="2850-Phatr34672"/>
    <dbReference type="GeneID" id="7200078"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34672"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="InParanoid" id="B7FWC8"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="51"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38671" checksum="214931E453764A41" modified="2009-02-10" version="1">MSSTTTTPRTLHRKPKVVFLNAARLDYDQQLDWSRLRNLCDELTLGDRDTVTDEAELLRMVQQQDIVVAKEMPVPAHILAQFPNTVRLICEAGTGYNNWPVALARKSRDLPVCNLPTYSTEAVAHMAVTYIMNFSVSMFRQQEMLRQGDRRNFTGPFTLPLRELNGSTVGLVSGAGRIGTRVAHVCLALGMKVYVSSRAGQFAPDHTLYGHPDVVCTSDVDEVLRVADYVSIHTPLNEQTRGSFGKAQIERMKPTAFLINTARGAVCAEDELVACLRDNVIAGAGLDVTATEPPAMDSPLWDLPNCWLSPHTGWRRLETRQRLVDMTADNIEAFVNANSPKDYINVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWG2</accession>
    <name>B7FWG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179380.1">
        <property type="nucleotide sequence ID" value="XM_002179344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWG2"/>
    <dbReference type="STRING" id="556484.B7FWG2"/>
    <dbReference type="PaxDb" id="2850-Phatr45097"/>
    <dbReference type="GeneID" id="7200298"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45097"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1638357_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWG2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF751">
        <property type="entry name" value="OS06G0255100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="233" mass="26528" checksum="9E6E857F8ED8404C" modified="2009-02-10" version="1">MTSSIGNIPVLDIRLFYSNPHHFVDQLCQACHCVGFFLLRHDLPPALAERQLDVTRQFFEKPLSEKMKISYETRASFRGYMKLGMENTAGRTDLREQVEYAVEYDTSRFLKEAASWPAYNRLRAQNPWPDDETETSFRRTTTDFASHVCRIAEILREALCLALGMEGNALDCFFAEPHWALKLVSYPHVADESGKDSFGVGSHTDTNFLTMVLQDDVGGLQVFSQGNWIDVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX85</accession>
    <name>B7FX85_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179295.1">
        <property type="nucleotide sequence ID" value="XM_002179259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX85"/>
    <dbReference type="STRING" id="556484.B7FX85"/>
    <dbReference type="PaxDb" id="2850-Phatr11888"/>
    <dbReference type="GeneID" id="7199956"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11888"/>
    <dbReference type="HOGENOM" id="CLU_732520_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX85"/>
    <dbReference type="OrthoDB" id="49060at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="68" mass="7876" checksum="3CA511716BA116AE" modified="2009-02-10" version="1" fragment="single">KKPKDMPKRPLSAYNLFFQEERNRLINSDKAGVGFENMAKTIAAKWRSLDVDAKAPYEEKATVNKQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX95</accession>
    <name>B7FX95_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179300.1">
        <property type="nucleotide sequence ID" value="XM_002179264.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FX95"/>
    <dbReference type="PaxDb" id="2850-Phatr45316"/>
    <dbReference type="GeneID" id="7199961"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45316"/>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251083_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX95"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="2">
        <location>
            <begin position="347"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1451" mass="159483" checksum="AF584194CFFBB693" modified="2009-02-10" version="1">MVQSAKNSELPKHQVSETTDPATREESFSTSTKGAAGDSLHEQSLDSLKAPSEKIVADDVTEDEQDDGDNASLHSPTPPELLMLDDMEGDVEDEDSLMDPEDSLPLMYYTRLLEQLPRQSVPQSEDQMSTVAPLATDCTCSAMGKVILSSETTLAVPDVSNETLPRTESSSSPNESRNVPVSADLWQAQPIYLTALGFQDGSVYIVDSQNGTTVAGHDQLYLHEITASSTNIMSGTGSHKKRDAVVALSWDSTGTVLSAIDAVGMCAVWEIRYQIQMQSSVIPPTISTATATPATRETSSNMFRTLMSAWTGGNEARNTSEAPSILGSVPTLTVASIQAHRVSYPKSFGVPTQLALDPSYKRRREKGLLVGFTDGRLVLTKRGFVFQRRSDSVLYQGTDGPVQALTWRANVVAWADNSGVRLLDAESWSRIAHVDRPAGARPTLYPTLCDLQPTIVWETSRRLLVAWGDCLLTLLVRESKVTSPVSANSTASDGNTNINTMSGAPAVVIRRTVECTMAWALECVACGVAPLDAEHVVVLGLVPPQDFDVVSETTQANARNEIELQIISRTDGVVVYSDLLPLMRKSSKNGYRRAKPAESAAPYCLLSSFAVPRMENTFEFQNDEPGDVGIDQQINPSLFSAPEIPRKIFRDSHLRWNLSMIEFEEATNYKSTVGTQGREKHLVIDDVAHDATSVDSDDYGCVIEPLSKMEETEQLLASVSPPVMIVTAGSDVVSVRMRDVDDAISSALLMRKAGLALRTGLKYIRRLQKYEIEDLVDEYFAAVLRLPREQGLMSSFVNDEEKNMAPTRLSLRRMKLAAVAMPVLFGGNVQLWERWTAHLEKIPGGLFAIREAIPVRDPKLSNEFYTRILKTMFRHAHETISRSCTSARERLAGEAENHFLCALLCWGTTNILRVHVDLYRYQRDYNSSPSTSTMLRAVEKGLRGRREQTAASYLLPTFRSAEQPSVEALNEISGSGEVSDSLYSVDEMLSYLRSGDAQRSESVDIKVSDMAGTIGMTDKVSSIALDAVAKLDMMKGRFDDALRALLEIGVTNSHLTLEDVERSALSAFSSSKKASKSKATNNHVFVLLVIEKYHLHQCLLDPKFLREALSTSPLFALVRLVGLERLGDFLIEHCVAPQGENTPHSLSQVYTPHSQSDKTNGERRGTLPLDLVAEQLEANQKLLYWYLHLVFVSRPELYVNFPNTANPPRNIVNLHRKAVSLYIKFAGANRDSAALLESTEAYRAIETTTPFLAFLRSILSLGGVSAMEVGKLLEIERKGGAGNSSTFALELAFILEHFGGGTEAEASLILDLLLRGAKSLMLAVAYAQRNADHNYFLWEILIDFCLGKTPDAGYQLKNRNDGALFGSLLEAAALSGADLATLVTKIPPRMSIEGLRPRLVAAVADYRLKLSMHECTSSVAFSEKASLMKESAHRSRRGMRGEWEGTDIQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXA6</accession>
    <name>B7FXA6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179305.1">
        <property type="nucleotide sequence ID" value="XM_002179269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXA6"/>
    <dbReference type="STRING" id="556484.B7FXA6"/>
    <dbReference type="PaxDb" id="2850-Phatr45325"/>
    <dbReference type="GeneID" id="7199967"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45325"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604966_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXA6"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="331" mass="34981" checksum="A5C6DDD421FFB12B" modified="2009-02-10" version="1" fragment="single">MAKPPFNPFRDLLSGVIMAATSVPQLIAYAETVGYAGYRGLATAGPPLAAWGIVTGSPFMNAGVTSITALMAKSDLDGEAYVARYGEEAYVDLVAAYSLYIGLASVVLALIGFGKLAKWVPQPVRSGFKWGCAVGVLVSAVPNGFFALGGSELKQYVAESTLRDLVAPFQAAFPGLPNVTNFIFALIHPNMWGLEPTIMFVLGTAFIMEGKTYLPRFLPPGTEVILVTAAATAYSVLYNYSGGVVGEIPALDPDAGIFFGGLRIPVEVVDVRKLVTEVPIVTQFGGSWFMLALSASIFAGVNFLSVMGIASGFENEDGIPWNAERELIAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXC5</accession>
    <name>B7FXC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trs120/TRAPPC9 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179531.1">
        <property type="nucleotide sequence ID" value="XM_002179495.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXC5"/>
    <dbReference type="PaxDb" id="2850-Phatr45340"/>
    <dbReference type="GeneID" id="7200032"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45340"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244003_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXC5"/>
    <dbReference type="OMA" id="PRKAAFF"/>
    <dbReference type="OrthoDB" id="39598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1608" mass="175695" checksum="05C77796D96D3485" modified="2009-02-10" version="1">MTPPSSTGLSMVPGNPTFRDSAVNMVALVPLLSSNKDGDISTTRSAHSFGELWTALARHANIDTDANAGSTSELKHQELLMVVPNSSLTCPGDWRYNDTPLKAFHWQHGCQRFAIFDGRPTQSRSAHDRLYNHALTRDWIDAVPSFRVAAVVGVLNMHDCGDLADLHRAEEELTSWASRYATPPYAVTAHAQTWERDTPFTRLFVFDSFDEACQKIDLNASNLGNRVLAFPPTDETHAAMIELHLNVVVNDLAVAIFCALEARIRESEEIVKHSEPAASTTTSGSAANQPKTRRTLSRIMSAGSSSSDKETEDLPSASTKLSLSNMVTLVNPASKLATDSHQSKDRNFKKGKLAKDKDDKSVEPKNTNAKPPAFPPKTPMNGNSASSSTAKGPQLLTPMDEVWDLSELSPKDAHAVRKRELGRRQKYTADLALLAGSPLDAYERYLAAAEALKVGTPDPLWYALTLEGCAASHIAMADAGGYGVDEYLENNFQMPDEIMALVKKETQPEKRITANKQTLPDVVMALCDEALNITNRHTHTGSFYTSLLLRMANYVSEHAEAHLRCRWGEGVGSFSGNANDSPRCEKPSVRRLQFHELKTAEGNDIIAINEMNRIKKFCELLHAAVSAGALDTETRVDVAAKAASSCLDGVPASCWVQSTTNRIRLPRKAAFFATVAADALSVESGRGNAAAAEALWLSATHLYTATPNHADGTGSYGWASLRASTLHALSLLSNSTASQQAAEQLLELLWEISPDLSGKPDGKTMSKKVLNINMDIEKESLPSEENEGSKDTHNRSGVDTDTVAATTSAFAKKIQESFTSMTADSSLLAVQAKWADEGPIEAINFPFSPSLKCSSAKLALGSVWSQATKDECADAQLACIDRIAALHRALPTRSGAKNTPIAEGTQNDVLPLYIASEISVRSEPILELECVKLSTTLPAEDQGAMATFYNPFSRKENNVQVTRVAGGEERAFSIQFGNRLVIPLIIQRCDLVFGDNANDRIQATPLSFVVPPKATNFVVQFPFMFLSEISSDRVEDVPNLFEVKGLNLNFMGRMFFVSMYSAGTAPTTKDFKPLCATEAAGKYPLMTVEKKEDKKVVEKPRLEAFHYQPRLQIFFHLTGVPLQSEALFAISLSPCEVYSLPELRLVNYAGSTGHGKIEQLQIVVMGLLGIGERVVFDSSARAGGEAVQSTETFATGLNDEKDAPAVCVRAVTQSLRVDGINNRDNESNTLTLQIAGSHNLNVKLLKNYCFIIRFRFRGKATRTTEVWRKVDIRIQLTSIQGPAISSITFQPNLLKSCGFDQLCNSLQARSPLKCAERNSEMSSGGTFSEIENLDAPNCIGTSTGIHVCTKVLIFVATVANPFGCDIVLSRPGGFVGGFAGHLLSTVLVKAGLSTSFPVCIRRIAPKNEDGSEVNILDEFSSQTRLLWTLKDTQNPISSIGKGFVQLNTETLREQIRINPAFLCKICYSPCEMQLYMGGIPVDEKSTEISSPLGSPVDLAVEVKLASWVSIDVLKFTDLSVEFFCARQDGTFSSKNDHVWCGKLRQRLNWEEEDVNSARSHRVRVVFVDGGRFLLSVCIRISRGKDSEEVWWAPVAARVYADNAKLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXC6</accession>
    <name>B7FXC6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179314.1">
        <property type="nucleotide sequence ID" value="XM_002179278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXC6"/>
    <dbReference type="PaxDb" id="2850-Phatr45341"/>
    <dbReference type="GeneID" id="7199977"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45341"/>
    <dbReference type="HOGENOM" id="CLU_644760_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXC6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="252" mass="28026" checksum="458675F200DED13A" modified="2009-02-10" version="1">MDLSMRFNNAGVRMLDAGQQVIAMDLFRGALESKLAYERTHRPERPDYIASTKRCVTPDCVTTAEEHLVNEDKYVHHEPVAFSLATPMVTEDNFLPGKGNVPKTPPALFESEPENPTLIRQSGDYLLVAKPFALPLSDCSRTSTQKRSAIIVFNLGLVNQLADASSSKAAAFYEISASLLANELYFPHSNLLRIAILNNFAVWSHGYGDEQSKRASYELLINALAESSSSLDQTVRKAVQVNMERFREGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXQ6</accession>
    <name>B7FXQ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179809.1">
        <property type="nucleotide sequence ID" value="XM_002179773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr35156"/>
    <dbReference type="GeneID" id="7200554"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35156"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1942191_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXQ6"/>
    <dbReference type="OMA" id="TSIKTWA"/>
    <dbReference type="OrthoDB" id="188299at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14976" checksum="92D6F2AD6180BAFE" modified="2009-02-10" version="1">MFTFSRLAARRVATSTRRNMAEMPVPQSRNAKLWEGHPTNEGWETTVMWLYPVSVILFAAAHGLAPETGIRAWAQQEARARLELKAQGKVDFEFGKHYQNLEKNQEGSWDKFTEKAVRMTDEDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXS4</accession>
    <name>B7FXS4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41125</name>
        <name evidence="3" type="ORF">PHATRDRAFT_45461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179609.1">
        <property type="nucleotide sequence ID" value="XM_002179573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185190.1">
        <property type="nucleotide sequence ID" value="XM_002185154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXS4"/>
    <dbReference type="PaxDb" id="2850-Phatr41125"/>
    <dbReference type="GeneID" id="7199085"/>
    <dbReference type="GeneID" id="7200565"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41125"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45461"/>
    <dbReference type="eggNOG" id="ENOG502TM9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2125905_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXS4"/>
    <dbReference type="OMA" id="REGQMIE"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="114" mass="12563" checksum="BBA9D8F05B8C099A" modified="2009-02-10" version="1">MTKEPKSSGGLKGLLQRTGKFFYTTGVYARDKGSTAFKWGYQVGGQVAFAVATTSMVMLMPLLFEIAREGQMLESERAQVKDYKGRGYSDRQLQELGFSEAALHTPSVASLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXX8</accession>
    <name>B7FXX8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_35233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179637.1">
        <property type="nucleotide sequence ID" value="XM_002179601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXX8"/>
    <dbReference type="STRING" id="556484.B7FXX8"/>
    <dbReference type="PaxDb" id="2850-Phatr35233"/>
    <dbReference type="GeneID" id="7200718"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35233"/>
    <dbReference type="eggNOG" id="KOG0165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283633_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXX8"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21224">
        <property type="entry name" value="CH_ASPM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="578"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="753"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="921" mass="102778" checksum="0988DE7C41834687" modified="2009-02-10" version="1">MIGNSNQQHVGDSRRVALGTRVPLGRRGTKDDAKPTPKPSSSLHVTFPRTTPLDKENGHGIRRDGRPTTTATKTSTTGSGSSARLDAKSTTTTTTPREVSFRSVLRATVTPRRPHQSTVPSRLPPHTPAVPAPGRHQIATTPRSLLTNELELLDGDDTFLCSPAVGTPRLPLPTFHMPEATPAIQESAKAVEGPVPSMEPTRSTQHPRLPPVVPAVPISVPNSQAPSTRPPVAEPRMRPQASQQLPTTNRTVVSRVEAPPPSTQSRWARNRLSTYPTPSPTPFTPRGVCMDLSDMFQDASFSTRATAHKSASRAHVPHSVTSRRALLASVAKPTPADTSLLDNEQDHDWADQQCQAFSSWLNYTFTPSEDKDHEAALASETTHERGVALRTLVLHQRMAQARRSALALFHTDPVLQKSRQRLLQEISKGKLRIRPDRDLAVNLTLRNQAVALCLSYSTPWLRLGLETLFGESILPSVPHHFSPHGNPVASRKVPTTRMKAALQTFLIQRVLSDDLVLAKYTKGLCKVPSGSFETKYRAEIRNLALYRLLLLFLFLDRAKENNLLDKAPRLFAKTASVKSTREVLLTFCRDFLSSEGDFVKHLSRMGIQVHYKQEPVDELDFTITNLAVDLRDGVRLARLLEILSHAPRKSLLVKLRLPAVSRLQKLHNVGLVLRRFRNMGVPLSDEVVAHHIVDGHREMVLKLMWAVVAHCCLNDLVNVHAVEAEIARVERAHRQAVVYQNYEPDVKVPSVLEELHSLLLRWCHAVCSTLGTAVRNLTTDFADGRAICLLIHYYHPALLRLSEIRPTSRFSPRSLTQVRALENEMYNSQLANTRMSELGGIPRIVPECDTNNVPEAKSMLLCLSFLCSRLLESSTEIRAILLIQNRYRAYRKARLRRRQRHSTTAQPSGSSNDSYEMVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY16</accession>
    <name>B7FY16_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179857.1">
        <property type="nucleotide sequence ID" value="XM_002179821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY16"/>
    <dbReference type="STRING" id="556484.B7FY16"/>
    <dbReference type="PaxDb" id="2850-Phatr45542"/>
    <dbReference type="GeneID" id="7200732"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45542"/>
    <dbReference type="eggNOG" id="ENOG502R9D8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FY16"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="363" mass="40659" checksum="2CEC722D43FDC490" modified="2009-02-10" version="1">MPDHNRKRPTGFFSQQGTSGSSSYKGLPPPPPPPIPGTFHSEQSYFYNYNNVPQLNGLNHLPSKNLSDLHSHYQDHRSPNPAFHSLEHHSQSTIHRKRPRDDTEKPQWKCSPCKLILESEGALQAHKESHISCTACNFEGAPKVVKGHFQACHGKFSGAGFKQVTIAVPGCPIQRFKICVGNRPEDVQRWIAERKKRFPRRLPCPAEDVFDSRELAQSTSMKGGLGSLLEGYGSSSSEEGAVDESPPGAANAVQSETVEGEIVENESAKLELRHAGNELWDLRKQRPCHHFQRNGRCRNGRQCPYSHDVAVRGRSLKKSKESKNLLEKLLTNDVKREATLTLQILEYLVDTSFLSKPDRKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY77</accession>
    <name>B7FY77_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179687.1">
        <property type="nucleotide sequence ID" value="XM_002179651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY77"/>
    <dbReference type="STRING" id="556484.B7FY77"/>
    <dbReference type="PaxDb" id="2850-Phatr45597"/>
    <dbReference type="GeneID" id="7200378"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45597"/>
    <dbReference type="eggNOG" id="ENOG502SEFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468915_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY77"/>
    <dbReference type="OrthoDB" id="50252at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="6">
        <location>
            <begin position="117"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="582" mass="65677" checksum="414B961A77B351B9" modified="2009-02-10" version="1">MGPCSNPNLSLTNTMIQAQELSPLINHCNKEFCAYSNESLSTLESADSRAGRTEGADDYDYDIETFAKLETRRKSSTKSWNIISRFKLDRGALQFAVRMAVLLTISSLFVLIRSEKWKYPDGMWVLVSVLFVSWFPSLDAASVIEKITQRLIGTFVGAFLGLSCGFFSIWAFPTQTYQAFFLTACMFIFNFGIIFLSGHCKVGQEKVIKQYAYATVLCVLTFCICMLPFGLDKDPKWELGVWRVCNVIVGCLLGALGSIFVWPKSTMAVLHEKTARQVKLAGEASEAVLHMAADYFAGKVDVNRLADELMASPLETRMRWKINRINSGKLSEVSMRSNHADVALKKYEDAIADWKASKMLFPLIKYDPFRLRLGKRPEENECFSSFNKEIARTLARSLRIQTTIVVLDGMVRNDTEYDFGESDLVVFSETGTFIRQMLTLPFQIHLNNSAALSLFRCLDDIRRRITQLSDAVSKPDESAAHARYAGLERFKRSLVSEDDEFLHADDDVGRGIPEFASGSNENSLFFLQLVEHLVHRSLRLYQAWKHVEMQSLQLDDPAIRALLVNSSSETRPGDSLRSLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYS7</accession>
    <name>B7FYS7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_35620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180030.1">
        <property type="nucleotide sequence ID" value="XM_002179994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYS7"/>
    <dbReference type="PaxDb" id="2850-Phatr35620"/>
    <dbReference type="GeneID" id="7200826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35620"/>
    <dbReference type="InParanoid" id="B7FYS7"/>
    <dbReference type="OrthoDB" id="44335at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41524" checksum="A9BEA5000F959C65" modified="2009-02-10" version="1">MVHWKFNRSKTSAEQQSFLKANRVFLVHTRILVVAPNTLVLLLPHEASLLGKGRAFGIKQTLEAREHTTHSTSIESVSSSIFRLPCQHRLKNVIRSADGSAENFGHHANIHGIFVDSVLCIAEAIRDHRAGKGSTVTRGTIAYAVGNQATCNFQGFLLQLAIGAPLYNCSLALCYLLTIMYDWSNDRLALMGRWVHMFIISFSVGTSILLLPLGQYNQITQVCWIIGYPSGCGNSSNIRSNIPCVRGNWSWNYGILLFYGPLWLCIVLTIIAMANIYLVLRATHTRMQRYSTQALNAMESNGTKIGNTTSEDRKSSDKTMVLEPIKKNSKDFVEASHATKAEDFLEETDLKGSRIVDKKTSTMELTSLHLGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZD8</accession>
    <name>B7FZD8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_45980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180131.1">
        <property type="nucleotide sequence ID" value="XM_002180095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZD8"/>
    <dbReference type="STRING" id="556484.B7FZD8"/>
    <dbReference type="PaxDb" id="2850-Phatr45980"/>
    <dbReference type="GeneID" id="7201047"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45980"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="InParanoid" id="B7FZD8"/>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="68"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC48322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="348" mass="38735" checksum="8A58049DDE8E5E34" modified="2009-02-10" version="1">MSASVSDPLATHGMLVLSILSAAALVGSVFYIFYPAVEVFRRGARGKDTLDVLQNAERVSATNPPLISIIIPAYNEEERITIMLQEAFDYLSLKSCPALESLRQAVRHYNSLATVDSRTIEWIVVNDGSTDQTCQVYESFVRNIPKQQTPMTWKCLSLARNSGKGAAVQAGMLRAKGLFRLMVDADGATSFRPGLEAVTASLQGTQAPIVFGSRAHLEQTVQRSFVRTTLMKGFHILVEWLVGAHEIRDTQCGFKIFRDDAAAVLFETLHLQRWAFDTELVFVAHRLQLPMQEVAVPWHEVEGSKLHTSAFSLIVVAVQMLRDMLCVRLCYTFGLWKVVTLQPASKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZH9</accession>
    <name>B7FZH9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180150.1">
        <property type="nucleotide sequence ID" value="XM_002180114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZH9"/>
    <dbReference type="PaxDb" id="2850-Phatr35877"/>
    <dbReference type="GeneID" id="7201069"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35877"/>
    <dbReference type="HOGENOM" id="CLU_1345506_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZH9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="204" mass="22907" checksum="6F1348E6ADB8AA5B" modified="2009-02-10" version="1">MVFAFVAFGVLRLASRRKRLVVFLVGETLTLNAASSGFYHATEDGPSPVAETDSHGQTRTILLQPDWENFVDPSTIVKQTIPNCDCVATSQIQLVISVGATRISSSSDSWHLQTMDHPGRLKTTGGDEFYVRFEWHRDDVTTKVVDSDRRGSRRRPNRRRKNVETTAVARVTDCTYGLAFVTTPLNTYLRVVMDFPMLPSIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZK3</accession>
    <name>B7FZK3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="11">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_27286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation. Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation. Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with host FBXW7; leading to FBXW7 autoubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180162.1">
        <property type="nucleotide sequence ID" value="XM_002180126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZK3"/>
    <dbReference type="STRING" id="556484.B7FZK3"/>
    <dbReference type="PaxDb" id="2850-Phatr27286"/>
    <dbReference type="GeneID" id="7200878"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27286"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZK3"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="13">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC48353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="163" mass="18301" checksum="26E9865C73468F84" modified="2009-02-10" version="1">MKEAKSQPGSYYYYNLETGECTWEEPFRTNSNTVSSDTTASMDKPTHVRALHILRKHKDSKRPSSWRVPKITISREQAREELQGLLEILQEEAHDMGSLKATFEELAKEESDCSSAKRGGDLGVFGRGKMRPEFEHAAFALDVGQLSGLIDTSSGVHIILRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZR7</accession>
    <name>B7FZR7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180195.1">
        <property type="nucleotide sequence ID" value="XM_002180159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZR7"/>
    <dbReference type="PaxDb" id="2850-Phatr45770"/>
    <dbReference type="GeneID" id="7200911"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45770"/>
    <dbReference type="eggNOG" id="KOG2501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967938_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZR7"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="288" mass="31955" checksum="811CA9D2745913A8" modified="2009-02-10" version="1">MSISSSRASSSLPQTSETADGITTTHLSMQKRKTGILPMTEADRNGRNAASNRRLRHKHVQTSDLVGLGKLMLGILALGLIVVVWQRKSLVNEQEIGGPIKVGNAPVDIDDSLREHPLHRYESLQYALDNSKIVALYFAASWCPMSTPVTNLIHDYFDDILLPPPPTNNAASNRRLAQRHGLSLVHVSSDVDEESMQKYIGKNWMAVPYNSPDRNALKEHFKTCAKRELSALGFKRKHEIPTLIVISGTSHEVLTFDGVRDVREYGAQAVDTWMELASLSDALSSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZT2</accession>
    <name>B7FZT2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_12810</name>
        <name evidence="8" type="ORF">PHATRDRAFT_12888</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180552.1">
        <property type="nucleotide sequence ID" value="XM_002180516.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180558.1">
        <property type="nucleotide sequence ID" value="XM_002180522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZT2"/>
    <dbReference type="STRING" id="556484.B7FZT2"/>
    <dbReference type="PaxDb" id="2850-Phatr12810"/>
    <dbReference type="GeneID" id="7201400"/>
    <dbReference type="GeneID" id="7201405"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12810"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12888"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611755_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZT2"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000003">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="21773" checksum="E5E1AFA55F750499" modified="2009-02-10" version="1" fragment="single">LGRQGSVTRKTKETSISATLRMDGSELGVHVNCGIKTLDTFLTLLATTACMSLDLTCHGDLWIDEHHTAEDVAIALGQVLTDALGTKAGLNRMWCASAEQNQTKIEVTMDLSNRPCFTHNLGLDNGEEMVGDLSLEMFEHILDSIVVNARMTVHILEVYATNNLEDTVQAVAIAFGQALKYCAMVDSRRAGATASSKGTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZU5</accession>
    <name>B7FZU5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180367.1">
        <property type="nucleotide sequence ID" value="XM_002180331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZU5"/>
    <dbReference type="PaxDb" id="2850-Phatr46037"/>
    <dbReference type="GeneID" id="7201524"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46037"/>
    <dbReference type="HOGENOM" id="CLU_604793_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZU5"/>
    <dbReference type="OrthoDB" id="49307at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="48806" checksum="1E750F60498B9608" modified="2009-02-10" version="1">MPRRSGRLQLNEVLEESKRTADKFVVVPQADPGNNSVMDEGGASPSTVTGRKRSRQSKDDHSDGVGDDFGENDLEDSDKEEVGKEPAKPRDVTSILSKWGRKGMKSKSMHASTGTIDGSDTSPNGSSGVREGENSTLSIGRKDKAEVTKVAPDAIPKKKVPRKTNDAPSSGPSLLSNLTPGIRPPPVNPQTSKSNSSTKSSAMPSNKSTFHSQPVKTKEYTQPASVRTQHITSDANKAGDLPRSTQESRQGLAPPNSATQAQPPTRLIASTSLPGLRVEERRLMAQLQDTCHRISDSGALPLPMSLAVDVGGSFLQNADNRYDFFDTNSNGEVVLQRPKPIFPEEFAAGMREHPLSWWGIVDPRLGENKYQKLGKVQHQAHDSEPRPSTFPRPGREMNAQQYHNQGWAGNGGGFVGGPNGRGGYRNSSRHGGGYGRPSGHNGNGPPPSFRGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G071</accession>
    <name>B7G071_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Galactosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_46140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180427.1">
        <property type="nucleotide sequence ID" value="XM_002180391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G071"/>
    <dbReference type="PaxDb" id="2850-Phatr46140"/>
    <dbReference type="GeneID" id="7201237"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46140"/>
    <dbReference type="eggNOG" id="KOG3916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066360_0_0_1"/>
    <dbReference type="InParanoid" id="B7G071"/>
    <dbReference type="OMA" id="MVKWEAL"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="361" mass="41849" checksum="FF08A66CBBF784D8" modified="2009-02-10" version="1">MSDMNRDAPLPPGWSRGYSTSQKRTFYFHQETKHTQWHFPTASEAKDPLKGKQRAELNKDREKKRQHEDSSGADKRPRGSPGEYMRKTVDTSVDDILELADSTSVAVIVPYRDIHSAQQRAAHLAKFVPHMQRFFNRLLKSGKVSDYHFYIIEQSDDGRKFNRGKLLNIGFDLARKSKRSHDVFIFHDVDLLPQDDLGSWYAKFPKSPIHIARVWGRYSNNPKYFGGVVSFSSSDYKRINGYPNTFWGWGGEDDEMQKRLERLGIRFESPPKGTLVDLENMTLPEKLNFLRANREWKCMVKWEALEEHEKTWKINGMADLKYKVLEQTSLDETGRATKATVDVQLNGDHWANEKSAIDFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G076</accession>
    <name>B7G076_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_54528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180629.1">
        <property type="nucleotide sequence ID" value="XM_002180593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G076"/>
    <dbReference type="FunCoup" id="B7G076">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G076"/>
    <dbReference type="PaxDb" id="2850-Phatr54528"/>
    <dbReference type="GeneID" id="7201362"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54528"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_1_1"/>
    <dbReference type="InParanoid" id="B7G076"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="385" mass="42620" checksum="0C42B3EEECA5D8D3" modified="2009-02-10" version="1">MRFTTKVLPSRTANLFVLTLNNPKALHALSLDMMHFFQDILKECYADDSVGALLVKSNTTGMKTKAFCAGGDVKRVYRSCLEEQDSSVLGQGKPGLDSAEFFRQEYVVNHMMATATKPQISLWDGIVMGGGVGISVHGKYRIATENTILAMPETNIGLFPDVGSMFWMPKMLPHSVATYMALTGHRLEAADLLYTGIATHYIPSARLDDLESALSTASKSFKPTERAEDFAAPPPMDPHDSYLAQERPAIDKVFGILSDRSKGVEDVVESLENLNSDFGRKTAGILNTMSPTSLKVTLEGLRRGKDMSRIGDDLCMEFRMSQACMRIGSDFHDGIRAALVDKDRNPQWQPATLAEVTEQIVESYFLPLEYEWEIPVTKTKISSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0R4</accession>
    <name>B7G0R4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180526.1">
        <property type="nucleotide sequence ID" value="XM_002180490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0R4"/>
    <dbReference type="PaxDb" id="2850-Phatr46296"/>
    <dbReference type="GeneID" id="7201226"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46296"/>
    <dbReference type="HOGENOM" id="CLU_295023_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0R4"/>
    <dbReference type="OrthoDB" id="54853at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="698" mass="77132" checksum="148A8BD17D2C704A" modified="2009-02-10" version="1">MSQNWDPDLLENRLQTILLKAFKQGQENTVKSIEKSSGKDPTVISSETFRVASVNATQKERGKASKRSSNGDGKAGASNVHPLKNPDTLTVPSKNFQWFKLPLVGQAQPVTSTNVHESLAANAVPTDDPSDTTWTKFPVEESAAWRAWNRYNEVYSESKPPTEELNAPDQDLFFQTETFATLVRMRLASGLVASALQLCHRRLNGIYRAVQKAMHQNETLHVVVWRDQMATLWCLYAHVWLEIGEMLSPVNPDDHSETPNVFKNAAGIILSAATTCPIVGNHGWLSIALARLEGSKHEAKYVSKGLDILWDGLDRAHVRAVKPRVKLHNFSKSIWRSFRIPSTVTWKISALKQDPLVLEKLRRSFQTVVNLPGRIALQSYAMVDHASTRMLADEFNRWNDLLVRSHFTGPDDVLMSSPNSASSSSLALLDWMLPLINRSLLPADVEMEYRYTAAEPLSDATLFKEQGKDTDKEEKGESSGKVGNGERDANEKKGKDVEKEAKGETDEKETPGDTYIKTVATDTLSFGKDDKDKLGFSETAATRAPKGSEKSTAAPPPSFSGQQETLSILPSALVSSREADVVSPEKSATANPQAVWKKAPPSSSPPPPWQTSDCEEDRLVEDPDDDKFHTPTLSLDTVKNTATVVTSGESRKSPLRNRPAEADPSSLTVCTEIEQACPHCQIFVPPQCMHSHRQVCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0S2</accession>
    <name>B7G0S2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180531.1">
        <property type="nucleotide sequence ID" value="XM_002180495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0S2"/>
    <dbReference type="PaxDb" id="2850-Phatr46303"/>
    <dbReference type="GeneID" id="7201379"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46303"/>
    <dbReference type="eggNOG" id="ENOG502SGI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086210_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0S2"/>
    <dbReference type="OMA" id="TENVPAW"/>
    <dbReference type="OrthoDB" id="199820at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855695" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="30500" checksum="809B24A2B1F5962E" modified="2009-02-10" version="1">MRLTEVPCRTGLAILALLIPATAWTSPPTTRHYYGSFASFSRGPGKHRALVERGATSIDVSVSTQDQPVLLDSETLLAAAESFMQTSTGYYSALDEDRLADDFVFRGPVIGPLGKHDYARVLEYFAVYRALPDVAPNAFGFSVDPEDPRRVWFLLRATGTYQQSLGGALGNLAATVTPPDQRQYRGSTEVWSVTFNERLQVRYLSAGYVADLYEPNATTGGRGLTFGVLASLGLPLPAGVGSPVLQVVQKVSRFLAGTGIVPLPYSSADNVPSWWKSDKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0S3</accession>
    <name>B7G0S3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180723.1">
        <property type="nucleotide sequence ID" value="XM_002180687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0S3"/>
    <dbReference type="STRING" id="556484.B7G0S3"/>
    <dbReference type="PaxDb" id="2850-Phatr46304"/>
    <dbReference type="GeneID" id="7201497"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46304"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898608_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0S3"/>
    <dbReference type="OMA" id="DEREYND"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="119"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="31545" checksum="0491F2059E62FD29" modified="2009-02-10" version="1">MTRYQLSMHAEHLPRNWFHTPSPYAVATITDGPLKGTKIGQTETLPKTTDPDWVAVLFFETDSSIYMPLKIQVFDEREYNDDILLGEATFEATEIFGAAGHLKSAQLNYKGPAQLYVSVQTSIQGNDRGIMELQFRGLDIKNIEPGLLGLGRSDPFLELAKKNADHTAGVVRWNVVHRSAHIQDHLNPFWESFTVGLEELCYNDLNWPMRILVKDWQANGRHRIIGQFETTMSNLMERVAVRGNADRQAAFEIFLDSLGGSSGKSKGFVCVLKATLYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G125</accession>
    <name>B7G125_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHATRDRAFT_56506</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180962.1">
        <property type="nucleotide sequence ID" value="XM_002180926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G125"/>
    <dbReference type="STRING" id="556484.B7G125"/>
    <dbReference type="PaxDb" id="2850-Phatr54569"/>
    <dbReference type="GeneID" id="7201649"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56506"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436473_0_0_1"/>
    <dbReference type="InParanoid" id="B7G125"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855280" description="glucan 1,3-beta-glucosidase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="150"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEC47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="594" mass="68197" checksum="0793241C148D7640" modified="2009-02-10" version="1">MLTRLTRFLAFAFILYKLPRFSLLRKAPAHNCDGQAMTDLSTNATAKDKKDGPNWIRGVNLGGWLVMERYIVPYQFAITTCHVQGDFCWYPGALSAPPLLHKDYKLCDLTRCHPYRNLTIFNGTDYPIDEWNLAKAFDNQTLATKWFDYHFNNFIRKEDLVRMKKAGLTHLRVPLPHWIRGDIRENEPWIAGNRWKVFVRLCQWCRNIGLEVWPNLHTAPGSQNGFDNSGIESSVYTCKGWGRHPENIERTLDVIHEISDAIAKDHLLDVVTGFGLLNEPFGDCKLNGYERFLEDALAITRANMGPNVHIFVSDLFGAPKFNDGSWWLDPVKYHNTYLDTHFYHTFDSHTRSMSPKEHINHVCHPEELQAEITSCCYQDAPSTNSTPSRGVKRISAEWSAAYDAMPGELLQFVMEGIAVNGTAPDFYRILEPDRREFLRKFVESQMVAYEAADSDLGRGWFYWTIKMEGGAFAEWDFSRGLEEGWIPPIATPGVASQDVYGNCDRILESTNNSMAIVHAFPWGDESYWKQYPIVESSETRIHRSFVWLGIAFVLAFALSNLLRRRRQLFGKYTSIDSEVDVEVPGKSNPQYVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G126</accession>
    <name>B7G126_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_13158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180963.1">
        <property type="nucleotide sequence ID" value="XM_002180927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G126"/>
    <dbReference type="FunCoup" id="B7G126">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G126"/>
    <dbReference type="PaxDb" id="2850-Phatr13158"/>
    <dbReference type="GeneID" id="7201768"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13158"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="InParanoid" id="B7G126"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="114" mass="11973" checksum="F6B0352BA3517DA5" modified="2009-02-10" version="1" fragment="single">KMVFCVNTNLSMGKGKIAAQCCHAAVGCYKRATKQCPAAVHAWEQTGCAKIALKCPSPDDMEQIAVIARAKGIPTYLVEDAGRTQIAAGSRTVLGLGPAPVSVFEGVSDHLKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G157</accession>
    <name>B7G157_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_54577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180978.1">
        <property type="nucleotide sequence ID" value="XM_002180942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G157"/>
    <dbReference type="STRING" id="556484.B7G157"/>
    <dbReference type="PaxDb" id="2850-Phatr54577"/>
    <dbReference type="GeneID" id="7201665"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54577"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_7_1"/>
    <dbReference type="InParanoid" id="B7G157"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="248"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="790" mass="88105" checksum="1799F8F7F27C455C" modified="2009-02-10" version="1" fragment="single">MLKERSALPIFSFRDELLRTIRVNPVTVVCAETGAGKTTQCPQYILEEALLGARGDTTTILCSQPRRVAAISVAERVSDEMCEDSVGRLVGYQIRLESRRSSETRLLFCTTGVILRRLVEDPTLKGISHVIVDEVHERQWQIDVLLVSLRALLQGTRSDLKVVLMSATLDADLFRSFFGGAPLVTVPGRTFPVATYHLEDILEATNHIIEEHSRYALRQYDARETVSMWVSTKGGERKRQTSQINYDLIEDLLEFVLLKNGTTQALSPPEGVDISNGALLIFLPGVGEIKALSERLRSSRMFGDARWFTIVPLHSLLSSAEQRRAFEKPLNGRRNIILSTNIAETSVTIPDVVCVLDSGRVREVHYEKRTATRKLVATWCSKASAKQRAGRAGRVQPGLCLKLFSSLTEQNNMRLATEPEIRRIPLEEVCLNILASGFAVKCSDFLSLTPEPPDPDNVNAALQVLQNIKALTYSDSTLSERLTPLGNHLSRLPVDVRLGKMMVFGTLFRCIDTIATIVAALSASKSPFVMSLQDAHQAKAAHSSFHHPKSDFLTLLNVWEAFNKCDTQSKSRQFCQDNFLSFAVLREMGDARIQYLELLVGIGLLDRVKAGYDNQSRRFDSRLSAKSQYNRNGRKESIVHTVICAGLYPNVARVHLTPQGDQTIWHKQERLFVHSSSVNAKASRQLPICWMGYHEKFGTGNRVSISTTFFVHPLALLLFGGEIVVLHPQKKVTIDGWMELSLAAKTGVMFIQLRKQIDSILSTLIDCTDKKILESEAAESMVDGIVSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1D3</accession>
    <name>B7G1D3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_46479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180835.1">
        <property type="nucleotide sequence ID" value="XM_002180799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1D3"/>
    <dbReference type="STRING" id="556484.B7G1D3"/>
    <dbReference type="PaxDb" id="2850-Phatr46479"/>
    <dbReference type="GeneID" id="7201570"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46479"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="InParanoid" id="B7G1D3"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="575"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="758" mass="83638" checksum="0EE66BE0C2C9545A" modified="2009-02-10" version="1">MVRKKASSTEDTATAATKHEQPLQAVLLADSFVNTFRPLSLDRPKMLCPLNNVTLIDYAVDFLAGAGVEELIVVCVSDKVETHVMQHTSLPIQVSVIKDSSLANAGDALRELDKRDLVQSDPFILMYGDVLTNVDVSGVIAAHKERHKKDRSAIMTILLKPVGVSDICGSSTKYSSIRTTTEDLVVGIDPTQDNRILVYDDKSSRASVSVPCSFFALHPQVDLRCDLLDCGIDICSPDVLARFTDEFDYSEIRRMFVANSVAEEEEGLQNKIYAHLLAPSEYAARVHDFSTYHAISRDLLRRWCYPVVPDNLPSGYEKQYRYVLQRHCMYYEHRNGKAKVGRSSQVQGAGMIGTCCCIGEDCQINCTVIGNHCHIAANVNIQGSHLWDNVVVEEGAVIVQSILADGCLVKAGAVVQRGCIIGAGCVIGAGCVLPEYTRLSLKVESDDNFDDDWGDDSSSEASEGSNAKKEVLESEAMYHKNVVGPDGKGIVWNYPLDDDEEETENLPPAEILRAQSIGFNPTALFAERQKIQREREDCFSDEESTGNINDLGEYDGGITFVSDDTNAQAASIVGRQKGVDVIKELKSICLEYEPASPIENLAIELNSFKFSQNATYVDCTTAATLAILEQMSITKDTTDGKLVQEFKSYLDHWAPLLQKMSIGLDEEKGIVLALEQCALESNERGQTLSSGTSFRFLLQTLHDEEIVSDEAILSWAADRQEDADGSRLKKLLDLPLVKDFLEWLEQESEDEDGSSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1L4</accession>
    <name>B7G1L4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_46548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180879.1">
        <property type="nucleotide sequence ID" value="XM_002180843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1L4"/>
    <dbReference type="STRING" id="556484.B7G1L4"/>
    <dbReference type="PaxDb" id="2850-Phatr46548"/>
    <dbReference type="GeneID" id="7201691"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46548"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_4_0_1"/>
    <dbReference type="InParanoid" id="B7G1L4"/>
    <dbReference type="OMA" id="NAVVCQV"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF13">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855716" description="Prolyl endopeptidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="581"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="793" mass="88177" checksum="15ADB60E8A090043" modified="2009-02-10" version="1">MYVSRISRTSLLWSLAAVWSSPVLSFARSTPRFFRVFSFPSASAIAMTSSTQPSVASTTLVEDPYLWLEDVESKESLDFAKAANDDCLSKLGHPETSSTGSYGKILSVLESDDRIPFVSQYGKDEQGNPILFNFWKDSKNPKGLWRKTTLSSYKSGTPAWEIVLNLDELAKTDDVSWVWKGSRALPRSRDPTDGQKVTRALLSLSRGGSDASHLKEFDLTTNTFVVDQPFVLPEAKTRASYKSRDVLWVGSDFGPDSLTDSGYPRTVREWVRGTNIDDAPTIFEGEQKDVAVSAYISDERTWNGGIYEIYSRSVTFYTSKVWMRKIQPEHLLTPDDPARQNIADPDELTPLDIQDDAEVSLLGNLMLISLRSDWTPVPGGPTYQRGSVIFALTDTFLEKGAAGSTYSVLFKPTDRTAYEYFTATKNYLVLSTMDNVKSKLQFYKIEGETLTLVSDPEAEAQIRDCSVSPVDPYDGSDEFWFTTSDFTTPSTLFLADAARVEGSSATDSFLQEKLRSLPPQYDASNLDVAQQIAVSNDGTEIPYFIIKNKDLKLDGKNPTLLYGYGGFEVSLGPHYIATAGLAWLERGGVYVEANIRGGGEFGPSWHQAALKANRNKAYEDFIAVGEHLIEAGICKPKTLAIRGGSNGGLLMGNMYTMRPDLWGAIHCAVPLLDMKRYHTLLAGASWMAEYGDPDTDDWEFLQKFSPYHNIDPTEEYPPILVTTSTRDDRVHPGHARKFVKKLWDDGKGKWPVYYYENIEGGHGGTADAKQSAFMTALAYDFMFDTLAKNAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1N9</accession>
    <name>B7G1N9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180889.1">
        <property type="nucleotide sequence ID" value="XM_002180853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1N9"/>
    <dbReference type="PaxDb" id="2850-Phatr46567"/>
    <dbReference type="GeneID" id="7201848"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46567"/>
    <dbReference type="HOGENOM" id="CLU_516289_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1N9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852860" evidence="2">
        <location>
            <begin position="30"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="528" mass="55880" checksum="365F4027F067045C" modified="2009-02-10" version="1">MMPFCTLQRLGLCLFLTVFFHSQYSRCSAQLDCIEPSTGALAKGFFVEDGLCVDAADATFFYGVRSAPISANGIQAGAPTDILVLFGSRGNPVEEAFDPKNFGLEIPGGGRLVVDLSPHFVYDATEALVPRENLLVELGTAMGNPIVGGASCYDRLDDAAVLVCGNWTASFGDNRNQIVYSPNSPVGLEGNRATEIGVKLAHIHPSLATPFESTLYHNANGTCVTLDGFLPQFCRFDDDCPANADCQITFFLQASITATVYDIDNQILQKATQSLTFRQAPVYAVYSTNVGLFSNQELFESVDYQYVEPNTLCRNTSIANSREAFSSAAPYAPRFIMFGQAYTDTTFPHPEVENLVVEINSDTKGTVLSAGAPIGSIDLVQPENAGGFLVSEGAGVILPSTVFGGTAFATPLQTGSVPGLYVVRVMMLDGTAAESRTVVQDNIGSPSTPASAVSPTLSPSALNPALPTTTVGPGPSSVTTATLTPVDGPGPPASTVAPASASRFRLGSIIWNAALLISLWGVSRWYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1S3</accession>
    <name>B7G1S3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_13192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180906.1">
        <property type="nucleotide sequence ID" value="XM_002180870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1S3"/>
    <dbReference type="STRING" id="556484.B7G1S3"/>
    <dbReference type="PaxDb" id="2850-Phatr13192"/>
    <dbReference type="GeneID" id="7201723"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13192"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1S3"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="74" mass="8801" checksum="B4805ED17085053E" modified="2009-02-10" version="1" fragment="single">MVRVFLKGGVWKNSEDEILKAAVQKYGKQQWARVASLLNRKTAKQAKARWHEWLDPDIRKTEWSRAEEEKLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2H2</accession>
    <name>B7G2H2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181377.1">
        <property type="nucleotide sequence ID" value="XM_002181341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2H2"/>
    <dbReference type="PaxDb" id="2850-Phatr37225"/>
    <dbReference type="GeneID" id="7202022"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37225"/>
    <dbReference type="HOGENOM" id="CLU_1104551_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2H2"/>
    <dbReference type="OrthoDB" id="45693at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="28170" checksum="BA1BD34EDED4C073" modified="2009-02-10" version="1">MYGHTPDISMFRFRFWEPVWYYEPTAKYPAPNFLPGCFIGIAWDHGDAFTYKIWTTPNNNWKQGRELVRNVVRSRHLEKKEPVVSYQDEDLLFSKTQPSRTQRPRSKKRNSCSNNSRGAEEVTLDGSELESLVRFDDTPPITSVDSEEQGGNKAESQSIHFSPVEVETSHGDELYEDSESKATNSTINSKRARKEVDNSALQSFDPLNNNAEVKMTSKINNYLDTNKSAASGAGGAHVTKIVGHNWMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2K7</accession>
    <name>B7G2K7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_37260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181223.1">
        <property type="nucleotide sequence ID" value="XM_002181187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2K7"/>
    <dbReference type="FunCoup" id="B7G2K7">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr37260"/>
    <dbReference type="GeneID" id="7201927"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37260"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678756_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2K7"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="49867" checksum="A8D79B3D1C16C4E2" modified="2009-02-10" version="1">MHDRSPSFKVAQILYTGTIEIVNLHTSELLQRMYARDLFSLNITSRQERQRSRRVRRTPPAIVPRKGQVIVSFGNVRAIAGLDSVQLLDAHKPVVRDFAEHLAKVYAKGAVEAGLSNELIFLEEVLRDTVETYSRRLRLYEPIVDSFLDKVASEVYSDTGVHQLVPLKDSLQSFEIQVKQCVECLAELLNDDDEMLSLLLTEQASAATTGKEVEFARHEDVDLLLGVYARQLGNILMEIQYMLGRLQSKQEFVALALAGYRNRMVRMNVHLGIATLSLGLGTTVAGFFGMNLVSGFEESQTAFANVVLGSGLAGLLIASGSMNYLSGRTMQKRASERLDEIETLTGALSDMCAIDYTVKSTVEQGQILDKDTFRRILKKSRQDGHISNAEVDLLFDVFDRVKDGYIHLEEFYPPALDQSLDHGLGETSAPSKEPQISNVLSETDTCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2M2</accession>
    <name>B7G2M2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181405.1">
        <property type="nucleotide sequence ID" value="XM_002181369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2M2"/>
    <dbReference type="PaxDb" id="2850-Phatr47140"/>
    <dbReference type="GeneID" id="7201933"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47140"/>
    <dbReference type="eggNOG" id="ENOG502SP3H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060859_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2M2"/>
    <dbReference type="OrthoDB" id="6052527at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42514" checksum="7C9EE8DA8A9C66EA" modified="2009-02-10" version="1">MSLRNSPSRGRIHSLAVIATAFIFVLHMYVGVYESASFYQQIPMIGTWSTESKSRVETDDTKRATRKHSMREIVPEPVPRPLIETLVTGQNVTGDVAWLLNMAVLGFSKCGTSFMMRYLGRHEEIAMLTDGEHCELTRRNEDSALIKSLMDGLPSGKIARGLKCPIHLESPRAMQSFSRYFPNTKIIVGVRHPVLWFESFYNYRHRDGKTQLLPAQELIGKCADLGPFEKVASVCTEGAKFHEPLARLGKTNMQSTDERQYFSADAQNVSDTDAFSGMKDLRNFLQVTKPFQPMVVEPKRLHDGTRIDICDPEYNHLREVLVDTGVKASRWIRRFFVHAEGVTVSSPKFLDQVLAKWEEDPCEERRAEKSSAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Z0</accession>
    <name>B7G2Z0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181697.1">
        <property type="nucleotide sequence ID" value="XM_002181661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Z0"/>
    <dbReference type="PaxDb" id="2850-Phatr47326"/>
    <dbReference type="GeneID" id="7202391"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47326"/>
    <dbReference type="eggNOG" id="ENOG502S5HM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423049_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Z0"/>
    <dbReference type="OMA" id="QDICIES"/>
    <dbReference type="OrthoDB" id="47990at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="648" mass="72037" checksum="F76F295EDB0519AF" modified="2009-02-10" version="1">MPRKRDRAAGNGALDAFGLLMNPRNSKKPSAASSRFVVCPAGCGKHVPSSNVNLHLDKCIRAQNICEREGSYIGREDTVNKVEAVSVEIGKPSHPMETAALTEQTSTSTHSLPRNTIEEDQEIATNKTDSVNSAFLPKMVPAEIAGRSPQRIENKTIVKPTTTEDTPSNYPAPDNGDEAFATKFGTQQTSEEDQTEHRTYQVTPDSAERPPQPKTKVPNVFSHMMNSSKATFSRPKPTKQVLHLSQDGSISLLFDTSDSPGPVAWSAIVLVKTRTSHDEDALTSSPEHPKIVQVTLSTAIPSYPDIEPSHRWVRRHSRLSVPVLKSILQKAVRRRKPLPAVKVAMELIDKSLGELLRRLPIIAIEDSTLHPALPLLVWLMMAHSKDYVLNPQLCRQVLQIVFEIAGCPYKDPLPYSTEGDTVHSRISLSSLDSGDDVLIWALLARAEYGGMKGDVLMLQQYANAWRQRMGEVSSTAPTTLVQQLHLPKPHVPVTWQNVPHIVHESAHKQALERIGLLGIEMLEISDLTLEGVDFHCSNILDELANDCHLVNVCHDLLLLSSSGEKMPAGMVDFRSWLVGFWKSCMWMYSAGVNRRRNLVTLVQPDNQGDKAVPSGSAMWNELLAPRVQEFQQNYLQQRLVRKHELDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3Y3</accession>
    <name>B7G3Y3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spc97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Spc97</name>
        <name evidence="9" type="ORF">PHATRDRAFT_47314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181520.1">
        <property type="nucleotide sequence ID" value="XM_002181484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3Y3"/>
    <dbReference type="STRING" id="556484.B7G3Y3"/>
    <dbReference type="PaxDb" id="2850-Phatr47314"/>
    <dbReference type="GeneID" id="7202386"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47314"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263709_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3Y3"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="570"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="864"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143179" checksum="DA1A4268AD4E59F2" modified="2009-02-10" version="1">MTSSLRNPDSAVARAAMARRRQRIPHHGAVATSSGTTDQPRDPTARRNSAVAETSRQVYDHERLLERSFEVADEAASVLASVRQRRQRDGSTRMNIEPESDSNLSTASHVPQQHQGRTPTVKFATQSSSTRTSVRNVPSSITPLLSAAVTVSSAPPPTSSRTPSTVTKVSPVPLPPPPSTSVDGTRPERAVSSHGPMSRTGSAPLSTSSAKATSAVPRTFVASRSTSPMPQQTSDSEEDNDQVSGETKLPPTVEELEPVLVEDDDDEGHKGWTANDSHAAATTHLHYGDRIRILCHTETPWSIVRESSPESKVTKAIAVPVTSATMAAFTVQRPRPTAQYDPCLRYGDVVSLHHTDGSIMSVHRQQSEKGHNIAYVPAWIDPVETDDERMEVWKLLRAVRNGLVRVGHSAIEKVTPRSGRTAPINSGDAILFRHEKTGGILRLDVSGHLEVATDSYVPSNSNIRQRRTLLTRLQTHDILEISKHETFHVITGTVPPTPLWTNGPADTQRSFSNGTHILDAQRHASTQVEEALFVDVDKKRKIELADHIGILQANRSKQMDTPLGQEMVLIDELLGSFVGLEGNSIRVHGAKSLDDDSFRFEVGTCTNLDEGLRSMVESLLPLSTAFVRVNHFVVSTLPRYEMGLVMHAFCEALDELLQNYVALTATLEREYRSLIDYSFGISKLQTHILSALHTMSVLHHAVETVRHSKGGALINSLQEYKDNRCDGDPAAESMMHNLVERASIPYMNMLLQWLNNGILDDPYSEFMVMWDKSKLWNEQYAVVEAHVLSRHFGSRQLIERTVSTGQYWNAVRRCQGHVQESAVLVDTLPLRYSDPIVSFASSVQLQYHKASRVLVSLLLNEYDLLGSLRLMKRYFLLDHGDFFVHFLDVAERELRKSLSSVSPGRIQHWLKMSIQLSESHTEDQAASPFFQTRGNRSLNGNSIRCNFAPESLADQLDQLHAATGGIDTHEPNTPQRHAYGASLDEGLTGLDAFLIELSFVPFPVSVVLSRRALTSYQLLFRHLFLTKHAERRLVGIWKDHQTMKELQQIRGSMGPAFLLRQRMLHFLQNLMYYMMFEVIEPNWSELENEIDSLKQQREYTVDDMLQVHSEFLQSTIQACLLTSRELIRALTRLLKTCLLFSDQMGHFIRATQINEDRDAVATEKQKVVERSLNGRDRVGVSISENRLRHTLEEARRERAERVNRQTLRVKREVANESYRWMIVRFEEVFSEHLKEFMVRLSSADDSYPTNAQLANLCVRLDYNGYVSKSIVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G409</accession>
    <name>B7G409_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_54757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181990.1">
        <property type="nucleotide sequence ID" value="XM_002181954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G409"/>
    <dbReference type="PaxDb" id="2850-Phatr54757"/>
    <dbReference type="GeneID" id="7202777"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54757"/>
    <dbReference type="eggNOG" id="ENOG502S48R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379248_0_0_1"/>
    <dbReference type="InParanoid" id="B7G409"/>
    <dbReference type="OrthoDB" id="46691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="370" mass="41387" checksum="6EC546FBE04C6998" modified="2009-02-10" version="1">MSRIPLELQAVFLASNQGEEVHKPPSNRSAFKLFQNLFGGFGRRKRTKRPNLKRLVSQSSFDTVGTVVNEDLSADTPSDQEVESVPTSPHEFLESILKSRGYCTKQYPVLQSAFFNQPTPLQLASYDVKLIDLLKRQDEEKIREILSCGVSANACNIHGESLMHKACRMGFHRILQIFIDFGGEIKISDAQGRTLLHDTCWGARPSFQAFSLLIQREPSLLFMADCRGVCPLDYVRKDHYIFWIDYLECIVDKYWPPVQSAPLPPAGIHQAAHSRPMPDPENALPLDVASMVASGRLTPKEALFLAADNIEDDDSCSCSSDDEGSSDDNSDSESDDDSFSDDDENSLIDELEEKELLADLAYSVVAFRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G424</accession>
    <name>B7G424_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181842.1">
        <property type="nucleotide sequence ID" value="XM_002181806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G424"/>
    <dbReference type="STRING" id="556484.B7G424"/>
    <dbReference type="PaxDb" id="2850-Phatr47550"/>
    <dbReference type="GeneID" id="7202622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47550"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_2_1_1"/>
    <dbReference type="InParanoid" id="B7G424"/>
    <dbReference type="OMA" id="WPMLWAH"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="452" mass="49951" checksum="961FA6DE331CF1BA" modified="2009-02-10" version="1">MYDAVVVGLGGVGSFALRALTHSGTRTDTEFVSNDTNTKNPKGKTYLGIERFARCHDRGSSHGYTRIYRQAYFEHANYVPWLKFSVKAFRELEVAQNVSLLHESGCIVMEPAVAQTEGDPSQISMPPYCKASYESALRHDIDVEFLDTTALKARFPQFLSDHDMVGLLEPQGAGLVRPERSIEAALRDAAEHEGVKIQEHTQVLSYRQKQYHDDTEIVEVVIQRDGEDASETILTKSLLIAAGAWASTFVPSWKPYVVPKRQLQGWIDVSHTADASLYDGGKLPGWILVTPSWPVPMYGPPCDPSGDDPAHRHWLKVGLHGRDIPIADLSQNPREASEDEIQEVREAATQVFTRDVWAKNDDQKFPDLAQVTPCIYTMTPDTHFVIGSPPLLSDRLGTSPAPKSCVFAIAGLSGHGFKMTPALGQMMADFANGVDVESVWGTSFCSPFRFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Q1</accession>
    <name>B7G4Q1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component Sec6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182114.1">
        <property type="nucleotide sequence ID" value="XM_002182078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Q1"/>
    <dbReference type="STRING" id="556484.B7G4Q1"/>
    <dbReference type="PaxDb" id="2850-Phatr47733"/>
    <dbReference type="GeneID" id="7202723"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47733"/>
    <dbReference type="HOGENOM" id="CLU_390560_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Q1"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="79900" checksum="5EE1B5D87DB971A1" modified="2009-02-10" version="1">MSHRHVAMSRVRPPGRKEPREAPSKPLAPPTVVSKSLASRFFRQSHTPLVVPPSPNTNRKAATRAAGTGAAVARDRRTAAQPPPEQLPALAAEFGAFALLDESAETVLVNDELPHAFRDFATKLWTTLHRRCQRANRDGGKTRIAITVKQYEALWNHMNGDYTEMLLDQSYEGHHDDLELHLMAANHVVQDFLQLQTLFHETRTPTRLRHALWEGLERFLAPRLVEQYQARLTTMTPAEAARTISWLDDFQESARARRLRVSDTWQHDQERLLQVYLQKGVRNEMATLVQRLAEQYSADEIRHDEHGHLVSTLPETVSFLYQQQHAVALECIPLVFHEQVLAACNEELGTLAGALLLVVHTVWKENNTGTHQYCALINDIYRLGEQCDNRNEEVLTNPAYMEAAEALSATLTQFSLQTTSFLCERIFTVLQEPESVLAPVGTAPWERQEIASPVDRTIATLQDYFVDLEAWLSGNYYYPKVLKQSLDFCVHQYVTSFFVNTMARGVHNPAAAAREIRNDHHRLDSYFSGEDLMPHHGVAGFYTRSQISLQLCILQNMAALIDPQRGPDDVGGDLKAVLVRLDRDVPGNPAVLHLLGLRKRHRGKESAEWLRAIAKAKQAVELDLQGNNATADSRNANNLLLLPKLCESRFLHNLRTGNGVQRQLSNTTQDFIESTRQLLVNEAKGLQRIRMYATHRGVGMRGSEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4W5</accession>
    <name>B7G4W5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182145.1">
        <property type="nucleotide sequence ID" value="XM_002182109.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47784"/>
    <dbReference type="GeneID" id="7203034"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47784"/>
    <dbReference type="eggNOG" id="ENOG502S9DC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259158_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4W5"/>
    <dbReference type="OrthoDB" id="41990at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF12">
        <property type="entry name" value="CHLORIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1317" mass="143125" checksum="41DC5C693F05EE28" modified="2009-02-10" version="1">MASRSTGGSQFRGRRRGDAVPNRTSEDARSARVSPAPLWIAPPSPVRRVDTHPHPSSSHGINRRGAISDGHPHDRHHRRSNNHSDLDMSNTPPRVDPRSNFAPLRMRADSTGSTRGAFYSGHVTASNTTTGATPNPVGEAQQPYLQEQQRSTGMRTTAPRRRKKKPAGVASYQEPAPRAPALSDQIRPSSMADLADLAFASLEGEDLELGNGSAELHTLVSRRGRNVDGNHPLSTMTDGNRYSSAIPEHSARPNILATIRDESSSSLREVPTAARSQRFSDSMRYSENSMGSLLGTNWVERGPGTGGSPRSSLNTASSRQPQRPRDDEIAMFSSLVHADYGATGGEPVNVAAAVALEHAAEEQKHLLNETFSSDDDDSSGTYSDEETEHDDVHRGFADQLVILWTAWLTQQAHYDEDTGQPYFEDATGWTPAGFVRHYLYNPLTPEFTSLQQFCWAVILGVLMGFYTALWKYVIETGLDFVWETVPTWLLQVGVFTDIDGAFPLYHYMWICPSIFSGVLSYVFVVLPIKIPDQNEWINCVHTRGVQDYRTFGTLFVLSTLGMLSGLSLGPELPLVLTAGMVGSWLGLVCKQSMLQARVMNLTAASAAVGGFFGFPMAGALFVLELPHRMGLQYFEALSPATISSIVAVLANRLITGNDVTGYYSYPFLTATLPSEIFTSAIVYGLFGAGVGIIYVKWVVWGKTLVHDWFQAPRENDISPITAPADHSGNGVREEVISLVSQKVQKSIPENRSMLSRTIKWFRCVIKEEPKRAAVAGALAGFIVGVIGMFVPHTMFWGEAQLQNLIDKGRTPLPIFGLAGEPTSALVALGYCMIDPNDPEAVKAGFDVGCSAVISFAKIVVVGLSLGTGIIGGQFWGPLFVGCSASHLFTDAVNMFADKFGFGQSLAAYPCVVILCTMGSAHVVTFRAHMAIMLILTLTISAFDPDGGSSIGAFKVAGDYSAVFPLLVVSVFVALMVSRGTVFYKTQRSRGDIMAVPEVLCEPGMEGRPMIMDFDIAADGASFIDAVSDTDEDYDDRNDTKLSPTTSYTGSYQVRAADDGMTQIDIENEFAGRAVWNKASSLRPSVSRTQADVRIGTKDAPRQFVEYDSGGIIPRSLSNPMSVDGELPGLDDLLRRTMVPKPTYAMSPHRHRRTQSAPIAPEPSFSGGGSASPDVKRVERSRGRDSFRFDIPIRERSNSGSSRGSLVRVTSYGELQQQQPSLLDQARMRAASSAADSRHHRVPSLPSGRHSRKNSESSMSYVNTNNISAVGTDDSGALTLDDIEKSFQNVMNKQLMGNLPQSRSPWTNNGNSGRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G590</accession>
    <name>B7G590_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_47886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182376.1">
        <property type="nucleotide sequence ID" value="XM_002182340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G590"/>
    <dbReference type="FunCoup" id="B7G590">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G590"/>
    <dbReference type="PaxDb" id="2850-Phatr47886"/>
    <dbReference type="GeneID" id="7203154"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47886"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="B7G590"/>
    <dbReference type="OMA" id="PEIIMGH"/>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="183"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="528" mass="58946" checksum="CE8464BF5690B7D9" modified="2009-02-10" version="1">MDMNNDSFQPLSKRQKTSDVEKSDEDLSNLVHGDEFALVGREQELDARRRRADRKLRLHSARQKESGEGTDRNDDTDKDFLLPVRYAQNDQLQATATLSNKDMETVYQPVDKDNFDMFSSSPSPQDNMDYQTNSATSKSKRGNEQGDWDDSEGYYKAVIGEIIRLEQTIDSASGNSSRSEISFRISGVVGKGVFSTVLKCTTVSNSSSIQLPPTVALKFIRHNDTMAKAALNEVQTLQRLKGCDGIVPLLLPLTETPMEHRGHVVLAFSCMEYNLRDVLQKFGKGVGLSLQAVRSYFGQLLAAATHLKKNNIIHADLKPDNILVSADFSFVQLADFGSAIDASESQQNQPTPYLVSRFYRAPEIILGLTPTFAVDLWSLSVTAAELFLGEVLFKGSSNNDMLYSFMQHMGPISNRIIRQHLAGCQRFPISKQFSQEGASFLFKQQTTDPVTGRHVHRMLSLATSSNGGRFPSATPLHRVLLRAKSTKDNRIVVNRFSDLLVGCLSLDPSRRMSLKETLQHSFFQLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5D1</accession>
    <name>B7G5D1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182226.1">
        <property type="nucleotide sequence ID" value="XM_002182190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5D1"/>
    <dbReference type="PaxDb" id="2850-Phatr47922"/>
    <dbReference type="GeneID" id="7203118"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47922"/>
    <dbReference type="eggNOG" id="ENOG502SJU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701074_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5D1"/>
    <dbReference type="OMA" id="CMSWEDD"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF8">
        <property type="entry name" value="HAD FAMILY HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853008" description="Haloacid dehalogenase-like hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44007" checksum="2F5E99562B8FA28D" modified="2009-02-10" version="1">MSYSIAPSLILLFGVLSGGQAFQFKAFAPRSLTRVLAEPSTTAPADSQTSSSNKGKTLGLLTFDLDDTLYPIDLVLNEANAAFARAMENFGYKGIQPSDINETSKTIREEIAARDPQEAAALTHTELRKLAIRREMEQITITRKLQSCADDWATPVADLSPVVVKHAKKWATEAVSPTIVQAVLNAWEMERHHAAERHLYPECVEVFERIKQDHPDVIIGAVTDGKANPLFMTFTLAPYFDFCMSWEDDQAGRRKFFKELGSIEGNADLKWIYDAALEKYQELASAAAALQKGDSAQDPNKIWIHVGDDLAYDVGGSAQSGAKTILVELDDEKYHQTARHRFELTKQPDWSTTSDIELEKRKVMNEAATNQIDRKIKFLTRLPEAINEVLEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5K2</accession>
    <name>B7G5K2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182430.1">
        <property type="nucleotide sequence ID" value="XM_002182394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5K2"/>
    <dbReference type="PaxDb" id="2850-Phatr38325"/>
    <dbReference type="GeneID" id="7203212"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38325"/>
    <dbReference type="eggNOG" id="ENOG502S861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_3_0_1"/>
    <dbReference type="InParanoid" id="B7G5K2"/>
    <dbReference type="OMA" id="HYLEWRD"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050744">
        <property type="entry name" value="AI-2_Isomerase_LsrG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336:SF1">
        <property type="entry name" value="(4S)-4-HYDROXY-5-PHOSPHONOOXYPENTANE-2,3-DIONE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336">
        <property type="entry name" value="QUINOL MONOOXYGENASE YGIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="117" mass="13169" checksum="D6AB0A034BD3DAB7" modified="2009-02-10" version="1">MATNVKYLCVHVFCQTKPGTADAFREASLRNARQSAQEPGVARFDVLQDREDPNAFCLVEVYRTPEAPAAHKETAHYLEWRDTVADFMAEPRKARKFDGLFPATGEGWDYAADATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5L5</accession>
    <name>B7G5L5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_38338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182437.1">
        <property type="nucleotide sequence ID" value="XM_002182401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5L5"/>
    <dbReference type="STRING" id="556484.B7G5L5"/>
    <dbReference type="PaxDb" id="2850-Phatr38338"/>
    <dbReference type="GeneID" id="7203232"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38338"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5L5"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="245" mass="27211" checksum="8AAFAB914371C0B3" modified="2009-02-10" version="1">MGGSTRIGSVLPYNIHKFQAWTFQLQWDEDANDEAQGMEVDATTGAQPTNAVVMFDRSLSFTIVHRMTLKRNQGPFAVLSEYNKKALEYGLPPFGNAIATFSVQAPMSEEAKKFCVNVKEDIHGIIQLSLAQLMEEIANKEESEMSDPSPLKDGEEDAAPENKKKVKKTNLVFATTRPLDWTDGKIQKAYQVELAMALKDKLAYIYGMRDKVGLDLALGLFGTDAEKAAFTTQNEAMDNCQSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5P3</accession>
    <name>B7G5P3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182447.1">
        <property type="nucleotide sequence ID" value="XM_002182411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5P3"/>
    <dbReference type="PaxDb" id="2850-Phatr48016"/>
    <dbReference type="GeneID" id="7203011"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48016"/>
    <dbReference type="HOGENOM" id="CLU_988530_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5P3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="30520" checksum="913693B0BFD5AB0B" modified="2009-02-10" version="1">MGRKSRRSRSVYDPAIEQEVTFAQSSDALAITDPLTLEAQDELNYLEEIIDPNSEQRDFQRRRRYQILVPMIFAAVLIVAATARLGNKRSDESSSSVRSYPSQTVLPAPPSDIDTKCSVAGVASALGRTACEMICEAADCCGFQSSLPLSCLSSNQAYCTEYLSSCSVLDEEPTKNEVGQGVSGDEDSVDQSPSANPETTSPTQSSVELNPGQGATYSPSVDLVLQVQVDEVCALDDMGDIIECTEICSPALCCYLPFKAEARCKEEPLNMNCETYRGCNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Q4</accession>
    <name>B7G5Q4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PGP_2</name>
        <name evidence="2" type="ORF">PHATRDRAFT_48026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182293.1">
        <property type="nucleotide sequence ID" value="XM_002182257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Q4"/>
    <dbReference type="STRING" id="556484.B7G5Q4"/>
    <dbReference type="GeneID" id="7203019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48026"/>
    <dbReference type="HOGENOM" id="CLU_043473_0_2_1"/>
    <dbReference type="InParanoid" id="B7G5Q4"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855801" evidence="1">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="389" mass="42039" checksum="1B2E6EBB6F0A7CFE" modified="2009-02-10" version="1">MSLRMAGTLALFVTGATTRALGRSGGTSKRPFSLRLPLQTGTQPTLALSLSSSASANKPTLSLTEQMRKESEAELAKLAHHYEDRARNDPAFADLAPIIWKTLDEATAFVNDHIETIMFDCDGVVYRTPDECPGAKECIQRLLDKGKRVFFVTNNAASNRSQLRAKLSEILAIENLTDDMMVPSSYSCARFLQREILDRKGRGRLFVIGSRGLCDELEQTGFEVLTGNGPLDSDASMTREDLATYPFSEHPVDAVVVANVLLQMNPDAPLVATNKDAFDLVGVDGRHIPGNGCAVVALEHSSKRTAINVGKPSATLADLIAADHGINPSRTMFVGDRLDTDIQFGVENGMHSVLVMTGVTTADSMVQLGNGTNDEPLPNIVIPHIGLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6B0</accession>
    <name>B7G6B0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182543.1">
        <property type="nucleotide sequence ID" value="XM_002182507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6B0"/>
    <dbReference type="PaxDb" id="2850-Phatr48195"/>
    <dbReference type="GeneID" id="7203517"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48195"/>
    <dbReference type="eggNOG" id="ENOG502RWHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2150755_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6B0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="112" mass="12409" checksum="DEE4B9AA10D41167" modified="2009-02-10" version="1">MVLATSANPRQASNDANNDGRSKNSEAYCERLALNLNTVKELPVSCRQYEGIVQKLETKEKESADPFAGMWAGSAAKARSSRAQGREHHAKIQRRLTTGATSTRRFSKLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6R6</accession>
    <name>B7G6R6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_14926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182777.1">
        <property type="nucleotide sequence ID" value="XM_002182741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6R6"/>
    <dbReference type="PaxDb" id="2850-Phatr14926"/>
    <dbReference type="GeneID" id="7203795"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14926"/>
    <dbReference type="eggNOG" id="ENOG502SZ8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113160_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6R6"/>
    <dbReference type="OrthoDB" id="48530at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="150" mass="16376" checksum="A4BA52782C1BC55B" modified="2009-02-10" version="1" fragment="single">DYSSTAGWESYYTKDQIKIPLTEWHSSVTLESLANHVPAWASSCLMIGCGTSHFPEVVRAGHTAKIVLLDSSPTCIRELKSRYGCSMCCICGDATRLSELVEPDSMDCIFDKGLMDAFFCGDGWTTPTEALLKGASSVLREGGIYLLVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Z2</accession>
    <name>B7G6Z2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-hmdU DNA kinase helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182813.1">
        <property type="nucleotide sequence ID" value="XM_002182777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Z2"/>
    <dbReference type="PaxDb" id="2850-Phatr48392"/>
    <dbReference type="GeneID" id="7203652"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48392"/>
    <dbReference type="HOGENOM" id="CLU_800406_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6Z2"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040684">
        <property type="entry name" value="HMUDK_hel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18723">
        <property type="entry name" value="HMUDK_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5-hmdU DNA kinase helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="273" mass="31596" checksum="F0189F4631472F69" modified="2009-02-10" version="1">MPYNDTATEPPEKKAKIQCSPKVSLSLWEIHGLDEKVPIHIPNLPTALRENRQNIADFFLFVYERQRIWERRNRDEAQPWSQNPVFLDCSFCNNYRELDRGTQFFHAHVLDLRDSMGPNVSKLDWLTAVLWASYVYRQVNKVESFLQLGFPEPRDAVSFLKRASSQFKEKGCSFFTGAHQTQGYVNYRRHVEAVARNDGKLLREVSKKISNASNTKLCLKHLRAFPGIGQFLAWQMLCDLRESYCIDAKVDDYCELGPGAISTCNLKLRVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7E7</accession>
    <name>B7G7E7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183133.1">
        <property type="nucleotide sequence ID" value="XM_002183097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7E7"/>
    <dbReference type="STRING" id="556484.B7G7E7"/>
    <dbReference type="PaxDb" id="2850-Phatr39223"/>
    <dbReference type="GeneID" id="7194925"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39223"/>
    <dbReference type="HOGENOM" id="CLU_000850_0_1_1"/>
    <dbReference type="InParanoid" id="B7G7E7"/>
    <dbReference type="OrthoDB" id="54627at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="728"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128354" checksum="D4527D79C0F85AFC" modified="2009-02-10" version="1">MDPLEHVLVNLLGATTPDSSYRRFFEEYGITQTSELASITENCLATVSYGVLTPSVGDTPATIVRMFLPPAQQDRILKIVKWFLSKGTNVTNETWFELTPEVLEYWQPASAIVAPATPVGSDARSSFVKSAAAKFRKTIKNHSVPYPKFSEDRFWVTWNTNIRIKLRIHGVQLVLDPDYLPETVDETDTFVEMQNFVFGVFNDILLTPRARGILHKHVDELDAQAVYRDLVASYGKGINAQITATSIETKLTLYSFATSKSKTCVAFLTTWRNLIYDLERINEFPLPDHQKSVRLKSAVRSHPQLKLFLGNVQLYSRTHVGKSADDSDFEYVYDLMLEHATDIDQTDLEDRGNNRGGCSANNAKSQSSSKKKTNKPIALSPKEKRTIMDQRGPRPAPAPAPALSVNAAATQPPPTVYVSDSTVVDNQSLASTHVPPAAGPGQLLRSLISNSAARQHPAPSNGATSDSFSVNGTTYRSEVNRSSVQYRLSTHDVSLNKDSLIDGGANGGLSGSDVTVISQSLLEATVSGIGNSELTNLRLSTVAGLIHTTDGPIIGVFHQYAHLGTGNTIHSCNQMRSWGVTVDDVPRTFGGKQRIVTSDGRFVIPLSVSGGLTYLSMQAPTEEDLDTFEWVPFTADNEWDPNGVSSPAAADNDLSLQLPAGHVPFRDERINNFGLLAHSAAVSRSPLNADALQPNFGWVPSARISRTFENTTQFARADVRLPLRKHFKSRFPAANVSRLNEIVATDTFFSDTPAADDGILNHGGATMAQLFVGKSSQITSVFPMKRESQFAHTFEDFIRTHGAPDALLSDNARAQIGQQALQILRMYAIDDMQCEPHHQHQNYAERRIQEVKKMVNTIMDRTNTPPEYWLLCLFYVTYLLNRLAVESLNWRTPLQVAHGQRPDISALLLFRWFEPVYYYDPDHASFPSASREKTGRWIGVAEHKGDALTYWILTDNTHQAIARSVVRSANVDNGLKNHRAANSSPDGGEPSNPKPIVLATSDLRHDATVDPSFEKSPAFSPDELIGRYLIREAPDGQSHRALVARKIIDADSDNHQAICFLLQIDEKDADEIISYNELSDLMEAQQSEPATNGNIEDHFKFTSIIGHQGPLQPTDAGYKGSSWNVLVQWEDGSQSYEPLIEMAKDDPVTLAMYASDNDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7J4</accession>
    <name>B7G7J4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183030.1">
        <property type="nucleotide sequence ID" value="XM_002182994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7J4"/>
    <dbReference type="PaxDb" id="2850-Phatr48520"/>
    <dbReference type="GeneID" id="7194769"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48520"/>
    <dbReference type="eggNOG" id="ENOG502T1YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390033_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7J4"/>
    <dbReference type="OrthoDB" id="10671113at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="708" mass="78160" checksum="0EB6E90BAAE25672" modified="2009-02-10" version="1">MAGNMSQLDDAIIAKIKKLVPQSLETRADAGDSNLNERCLSALLLSTRLSSTTKLQRIFYDRNILIDFILLLVEENATGTTLYARLAAQLAVRLAECEPDRDERDRATFQQRSCRRIGSALCGILDLRTRDTKKPLMIEVIDVEIVIALNELAARLVQYRTRTDGDGDIDNALLETILEQAWKLAINAAVHTEEAKGVSLSNDPLGPKLKQPSEIMHETLTQLLNQSSNVVCEQSLSVQMSAETTRLFFDHASRITNYKIPSYYRSALNWAREGLGSSPSSFLDESRESPSTTSECSSLRSASIQIILWTSHLLAALPSFQAQIDANEMEISEGLARLIVAGCVSSSAHHQDQSDTFRSLSWSTLGTLVQAIGWRWLFSVQWQHTSVFGSAHSVCILLRLAVGEWKIQLGFLLSETEDNEPDSQSLLNDSKVSIFQTCAQVIIAAVEYVVELATEVENDGSLSVPVDSVLHLRESLYECLDAIVQYFASFEESLTKGVRAELVDVCVIRVMSSLLMEMDAFETTLPTSTTLKEDGEQENAVLGALRRAMNVDIKQAREALLPGLASVFSSAKNHEDESDIRVGLLKDYDLVGDSLADFLTIFWNERDADGSSIEWACRTTELWLFLTDVTKVSTIQDGIVRWLQLSTIAQTRRPSGAGTSIHGGKESTQQAVYAAVGCYAFLQGDTKPGEPHASILQCALQECSELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7M8</accession>
    <name>B7G7M8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183046.1">
        <property type="nucleotide sequence ID" value="XM_002183010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7M8"/>
    <dbReference type="PaxDb" id="2850-Phatr15207"/>
    <dbReference type="GeneID" id="7194719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15207"/>
    <dbReference type="eggNOG" id="KOG0648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583275_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7M8"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="20943" checksum="7062E67DFB13EFD1" modified="2009-02-10" version="1" fragment="single">MTVQEFQSCLAQSLQQWEQQGRKGIWIHVPPGQADKIPIATSLGFDFHLIVAPENARKDGDGADPTHAGTPNVLVLTKWLPPNVPSRLPHGPTHQIGVGCLILHPLDETRMLVVQEKSGPAAAYGLWKMPTGLADPHEDLHDAAVRELHEETGLHASFQGVLVFRQAHASKKTATARLGRTVSDMFFVCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7X4</accession>
    <name>B7G7X4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_8000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183221.1">
        <property type="nucleotide sequence ID" value="XM_002183185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7X4"/>
    <dbReference type="STRING" id="556484.B7G7X4"/>
    <dbReference type="PaxDb" id="2850-Phatr8000"/>
    <dbReference type="GeneID" id="7194884"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8000"/>
    <dbReference type="eggNOG" id="KOG0839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237408_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7X4"/>
    <dbReference type="OrthoDB" id="46683at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="13288" checksum="3B046F10FC951AE2" modified="2009-02-10" version="1" fragment="single">EIFAADRLVIPDLQVTKMDNFKSLCVGASDWIEIEECNEKDLANWLRCARNLGYYIVGIEQTSSSVSLCEFQYPDAPTVLLLGKEKEGIPVEYLQLVDQCVEIPQLGIIRSLNVHVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G818</accession>
    <name>B7G818_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183240.1">
        <property type="nucleotide sequence ID" value="XM_002183204.1"/>
    </dbReference>
    <dbReference type="SMR" id="B7G818"/>
    <dbReference type="STRING" id="556484.B7G818"/>
    <dbReference type="PaxDb" id="2850-Phatr48666"/>
    <dbReference type="GeneID" id="7194903"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48666"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="InParanoid" id="B7G818"/>
    <dbReference type="OMA" id="HRGFDNG"/>
    <dbReference type="OrthoDB" id="39469at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="736"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1643" mass="180066" checksum="13F200A178EF96F0" modified="2009-02-10" version="1">MPQQPLSPRSDHSMGTRTDASTTPSIGDDKETGPVAPLVAASRHLLQSNGSILGRHVAQAILPKFPTLLSALPIDSMHPALSCIDGRKPITCAQIREFVLGLGTQLHNHGWGRGNRVAVVLPNGPELALALWGIGAWCCCVPLNANGAAMELESDLVASSCCLVIGVQGSTTRQLANKLNISFGGLTPDRFHAGLFSLSLPDAPHGLQSVCTRAVERDRSAGDPISPVSTIVKQTTVAPVPNAHDDIVLVLFTSGTTGSKKLVPHRLGDLLVSAACIAVSWNLTPADINCNLMPLFHVGGIVRQVFSPILSGGCVICCPSFDPLIFWNLLRSQSFTWYYAAPTMHQLILQTGRAEGFIEGNGSNETTTINPKLRMIANAAGGLLPSLARELQHIFGAAVLPSYGMTECMPISSPPATYQLEKPGTSGVSVGPELAILNLKTLDLLDHGKEGPICVRNEPCFRGYEDTPQEASFLPGGWFNTGDLGYIDEDGFLYITGRSKEVINRGGEIISPLEVEEALNGHVDVAASIAFSTQHSVLQEVVGIVIVPQPGRPRIDLPALHEFLGQGRLAAPKWPQCIVYMDSLPKSNTNKLLRVMLGQRLGLPELNDSMYSIDRTFQAKCPKPGTSVSVAIPCERVALPSDQVQQILREALVTNVNQEIVVVHHPTRMGSLVAYVYQVDRVAVIAAAKERLHAYAVPSHVVQMPSPFQVELDISPPQPSDAVGSILQKASNSGQGPMNPLVLSLQELFQELLDLDCLPAPRTNFFNLGGSSMLASQLASRVRKQHDVPFGGAEVFHHSSCEDIATLIRERQDGEWDICSSVANGDLASVASSLFSRNLDLKSTPFDPNKMNHSSSCCATFLQLMPLFVIYPVWQLSRFYLFFRLLLILLNAVPGGHHLVAFIISVVVFHFLWVLLTPLLFVLIKWTMIGTYRKGRYPLWGEYYLRWWFVDVMRKLIGRGIWGSNAATLNLYYRLLGARIGRYARISLEADIAEFDLINIGEGACIEYSTLRPFGVDNGAMILGPMGVGSFSSVGARSVVAPYTFIPDDTHLGAATSSYEISTLHINQSKQYNRQAFPEPGILAQLFVCRPIVFLVETMSHIPALLILYWMISMPWHDNEAFDTMSHLMEWLCNVRRIPFYIGIHVARALLAPIFQMGAAILVKRYIIGSFKPGPRDTASQWQLCRHQLVSTLFSRQNMQDCTELLGRHYELVSVLYRVLGAKVGNRVFWPGHQPVFSGEFDLLEIGDDVVFGSRATMICTTIDSCEKITLSAGSNVSDNAVVLPGSMLGKNAVLGSNAVCPGDWYLPEASVWFGAIAGEPVMLEKGVEDISHHILSSEVSPDRIQMQGDESTLRPFGKAFYYRQAPYFVLPMSFMILFTVLSKIMISLVHTVPLLGALHATAVYFYGHHDTQAYDSVSVASSQMYIVLLSFFLLTHAGRVAVWIGIELGAKWLFVGRRQPGRYNWDKTPYIQNWELYQIITKVRSSGRTNFMDLLAGTPFLVAFFRGLGCTIGRDCCLYPAGADPFMPEPDLVQMGDRCVIDCASVACHLNTRGNFELVKITLENDVTLRTRSRIQQGVHMENNSMLLEKSLAMTGEEIEANSVWQGAPAVLLFSYDTTTMATGRSTCSSDTSDSILDGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8E7</accession>
    <name>B7G8E7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183333.1">
        <property type="nucleotide sequence ID" value="XM_002183297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8E7"/>
    <dbReference type="STRING" id="556484.B7G8E7"/>
    <dbReference type="PaxDb" id="2850-Phatr48800"/>
    <dbReference type="GeneID" id="7195064"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48800"/>
    <dbReference type="eggNOG" id="ENOG502S98K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497501_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8E7"/>
    <dbReference type="OrthoDB" id="46629at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="300"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="55347" checksum="9D0942FE190822CB" modified="2009-02-10" version="1">MRNQGLEALAAIATASSSSGHTFSTNTNQDTNSAQQNSNNLNENRAFLGTKEAIGNAGCTSGVQNTSTSTTAAQAHPGEEVGSAVQQWISTGANQTTLGNTNLAFLTGLQQSDPSILLAMQNLAYYQLLMQSQGQNQQLYFQNGIPNPKLGMPATKHQAAMEVLGGIHCQSNPNLIDIQDSKAPDIKKQVLPKALTVNGPHITDYLSNISYAGSETSATMFPPTSSNVSKAGDALPLQPQVLAPQASDASFHTKESSLPVYASSQKEKKQQKRAANRRSAQLSRKRKKQFVEELKEENDDLRRKEQILKSIPDLIVVFDSSGKLLFVSQSASQFLSFSSGELLGTSFWDRICDDSMRLLKAAFMDSLAARQLDSETAPLGSGVWEVRLVDKDGSDSIVTLNGVVHFAGDRPECVCSMRPREKQSSEKNGKANSNCNADLANDSFPSKNSPHQSLLRVKPQQSVVSNDSSHGTRRKVKLAAYSNVGKGREAVRISDSCNSLSGSSESGSSDGLNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Q9</accession>
    <name>B7G8Q9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_48887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183385.1">
        <property type="nucleotide sequence ID" value="XM_002183349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8Q9"/>
    <dbReference type="PaxDb" id="2850-Phatr48887"/>
    <dbReference type="GeneID" id="7195167"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48887"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031934_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8Q9"/>
    <dbReference type="OMA" id="MATIAYP"/>
    <dbReference type="OrthoDB" id="10259408at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000031">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF235">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853084" evidence="11">
        <location>
            <begin position="26"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="13">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="358"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="54159" checksum="9A5601474F8F9515" modified="2009-02-10" version="1">MATIAYPLAWTAALALCFALFSAMARYGVGDALDTITVNGKTCSNGICVDQFDHWQTVPMTWKCRDLRDDCTLRAVRGLCQTDSLYTHPHCPVACGVCHNRTREIPFETSAPFSSHPRNRQGLVEVAGSRFGVPQLIPERGSDDRQGVLDRMQDAHEYWEDVVMEEDRYQPVRTLCRNEYELCALWAARGECTNNERFMKKSCPVVCYTCETLHVDALCPFDPNIPNAWQRGDLNRMFKRIVHDPTLAHYQTTVLSRPDYEPNDTVETASYQIGPWVVIIDDFLNETETSTLIALGADQGYERSTDVGEILEDGSYEDDESETRTSTNAWCYNECDDHEVTQIIWERMTFLTQIPPENSESLQMLRYEPGQFYAVHHDYIENDWNRAVGSRILTVFLYLNDVEEGGATNFPELELAVQPKRGRALLWPSVLDQYPHKKDDRTEHEAQVVTKGIKYGANAWFHQRDYQGSTQNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8T6</accession>
    <name>B7G8T6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_15399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183401.1">
        <property type="nucleotide sequence ID" value="XM_002183365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8T6"/>
    <dbReference type="STRING" id="556484.B7G8T6"/>
    <dbReference type="PaxDb" id="2850-Phatr15399"/>
    <dbReference type="GeneID" id="7194979"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15399"/>
    <dbReference type="eggNOG" id="KOG4072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100048_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8T6"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21711" checksum="4ACABFB3005E3FE7" modified="2009-02-10" version="1" fragment="single">QVDLGDMVKIKQVLDETVASAILENIAEDYGWDNFKLGIMALSCVFAMIAQFAPIPFPESRPVLGVCGALYFALSGILQFVTTFIDKDCILWTKPADISASTKNKDMHLYGLRIRSNLPRFSEWYEVILEFQKPKQASASPMVKHTWSIGQFFDKEGYFDEIGLSQEIDKLFKRFEAKDYDSAGSDEKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9L6</accession>
    <name>B7G9L6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_55004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183795.1">
        <property type="nucleotide sequence ID" value="XM_002183759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9L6"/>
    <dbReference type="PaxDb" id="2850-Phatr55004"/>
    <dbReference type="GeneID" id="7195640"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55004"/>
    <dbReference type="HOGENOM" id="CLU_702966_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9L6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="393" mass="41887" checksum="837B8BD2F8F70B72" modified="2009-02-10" version="1">MTAQLAQPISSRLSVTETATDPVVTAAEAEATVAASHSERRWSEDSTSSSSSSSSLQPALKSCLSSTNLSSLAPLKMKRNVSFHAIEIRTYVPDSASTTGRKSPLPTEPDRRLSIDDYEAGVRPGVSLPQSSSRGQQRATIVNKNNNNATPAWLEKAGRRFKKLLGGGRKPRNKASKKENTPPSVSQPQRYDVSKRPVLEDCTTSSLRKVQSLTDLDQLEWESDSSTSDEESGDNSTGSNTASNSSTTSIESPPSSPLSSATRAKSRFGTNEERSKGLAATTPSTVSSATAPLNHSLPRVSSASCNDLTSLVSQHQYPSTILEEFPSSNSLASLVETKTPISPAKVESQSLLQNESPVTSMSNLVSPANDPAWALNFTNDDSDSQSEDSALCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Q8</accession>
    <name>B7G9Q8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183820.1">
        <property type="nucleotide sequence ID" value="XM_002183784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Q8"/>
    <dbReference type="PaxDb" id="2850-Phatr49174"/>
    <dbReference type="GeneID" id="7195665"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49174"/>
    <dbReference type="InParanoid" id="B7G9Q8"/>
    <dbReference type="OrthoDB" id="43083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="23739" checksum="3122328D59F9DE5E" modified="2009-02-10" version="1">MVSVQVWKDMQAISGLSFGVFLCMHLFSHYSLRLSFETANSHLLRFRTIYQHPVFEISLLLSLLLHMTSNVQLYLLRRKVAKGVKGKTNGKDAQGTTEGAAELSAHRYAGYFLGLSLFGHVGATRLAPYMFLDDPSEYDYGFIKAVNDKVPYNLFAGYLCILGMAGGWHLIYGSLSAVSHLLGSPLLGKPFPTSVKYFAMASHVFMINGIVALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAB6</accession>
    <name>B7GAB6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184046.1">
        <property type="nucleotide sequence ID" value="XM_002184010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAB6"/>
    <dbReference type="PaxDb" id="2850-Phatr40043"/>
    <dbReference type="GeneID" id="7195873"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40043"/>
    <dbReference type="eggNOG" id="ENOG502SWRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1071417_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAB6"/>
    <dbReference type="OrthoDB" id="52239at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="28638" checksum="D2F736EE0F9E91A4" modified="2009-02-10" version="1">MVGSVVKPCRSKRLKGVLSTQTSGFSGASVEEKLGLQAEQRSDEPEVVLFQRGPGRDGLPRSGLFFSSLHTIYWIWYGFDFVPAINASPVADIHIDPMIPLVGTVFAAFIQLVFTSYPTRLVHKLTWRPTAQSLQLYTYSIPFIRPRTTPTVFPVGEIMLDASSSDTERILKEFGGNIGRFKGHLGISKPGGSWPPYLLDMREASDAPEPEILLEALLSPTGMTVGGAGAFQVRKTGSGEGKKKNRSRESSLKKIIRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAS2</accession>
    <name>B7GAS2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184126.1">
        <property type="nucleotide sequence ID" value="XM_002184090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAS2"/>
    <dbReference type="STRING" id="556484.B7GAS2"/>
    <dbReference type="PaxDb" id="2850-Phatr49487"/>
    <dbReference type="GeneID" id="7195717"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49487"/>
    <dbReference type="eggNOG" id="KOG3673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587238_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAS2"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="3">
        <location>
            <begin position="138"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="466" mass="52030" checksum="EB050716A5438E6C" modified="2009-02-10" version="1">MEGKRRRSESSSRQRKSYEHERDVYNEAIDPTASASRNSSVKSSWFRSIEYFRQDKAIAAGVPTDDSLVKSEIISISKQLSQVKRRLSPAAERCTEAMNSFYNDCATTGRQEFAAARRACNPYEVLGEGRNGGLNSMFINRSAIKLANIDAVLRFDLSRPGKNGQFSFVDLCAAPGGFSEYLGKRCHANAVPECRGYGMSLLSTNEYGEATKWKMDDSTSTENGTYAQYRVCEGSDGTGDILKWENIEALHNMVRDDISAVARVESSVEWGKVDLVVADGGFDAQRDSDHQEAISQKLVVCEIAAGLLLLKKGGKLMVKMFGFQTEIIRSVMEDLAFTFEEIIALKPISSRPASAERYVVFRGFKGNPADWEGQRWIDRMFLGKNSTQCARNRLQQPNCTNRLGVYLDAFDRDLLSLNLKTCFSILSFLENKCRAIHSQQRAGPDSDSQEATLVDVEAFKAAWNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBP0</accession>
    <name>B7GBP0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_40492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184480.1">
        <property type="nucleotide sequence ID" value="XM_002184444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBP0"/>
    <dbReference type="PaxDb" id="2850-Phatr40492"/>
    <dbReference type="GeneID" id="7198416"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40492"/>
    <dbReference type="eggNOG" id="ENOG502STWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638538_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBP0"/>
    <dbReference type="OrthoDB" id="47302at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="111"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="430" mass="46538" checksum="C3F8F6634AA392FB" modified="2009-02-10" version="1">MDSQLLDLYTNENATLFLVHSNLGFWSATSDEGRSAHDSFTVQLNFPASRPIVLHPAIEFMAIPPVRVFLGLLNIFVWYAANGMNGVAMQQYAGNLRDANMSLPLAVVAALSVTYMQLVAGALLGFFILRVFYAVNLGALLERPWSHWMGFLHAAGSVFTNAGFLYGSASLVQVIKLLEPFQTLLWGRLLGSEDTNSLQYIASMSLVVGGAISLVRSRPNPPHPVAVLSAILSGCTLSLRNVLQRGQVVAAESYDGGSIVQTSVVQFTLLSFYASMWAVALAALLHGLFGILGLDVSVSAWYEHIQPSTIFWHPLYNMTSVTTLAFCSALTHSLLNAGKRIASIILAIVWFREGYSLDTVTGLVVVSIGGCWYTLDRKKGNGTKHKSAPLQESLVKIIAAVAILVLLYILPLAATIFDSMSIPVETPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCQ1</accession>
    <name>B7GCQ1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_40896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184918.1">
        <property type="nucleotide sequence ID" value="XM_002184882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr40896"/>
    <dbReference type="GeneID" id="7198797"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40896"/>
    <dbReference type="HOGENOM" id="CLU_853818_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCQ1"/>
    <dbReference type="OrthoDB" id="38147at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF38">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="301" mass="33955" checksum="2FD4253D0F05F6A0" modified="2009-02-10" version="1">MVLSKDLLHVLRFGTLNDIRKILSYQPRLFRDHVELSMELPLHVVVREQRELSILRFTLRAFPNAIKVPDMHGQLPLHVAVQQRNWHIKGNGPIIVRELVRADPTTIGVPDWKDGYTPMHTAILYRCDPEIIQFLLHSCHGYNSTIKNANRRSQAGRLRRLPQPPRLDPCMVATMTGGYLPLHVAVFSKASVEIVQALVDACPKSLRIPDQRGFLPIHFAILSLSTTSDGSPEDGAERDSKIWSILGGDELAYGSSFMTKKQAKYQQSSNPPISQTTSKDGQCWVGMQKNGTENKIEIYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDF9</accession>
    <name>B7GDF9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185205.1">
        <property type="nucleotide sequence ID" value="XM_002185169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDF9"/>
    <dbReference type="PaxDb" id="2850-Phatr41157"/>
    <dbReference type="GeneID" id="7199021"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41157"/>
    <dbReference type="eggNOG" id="ENOG502SRI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386614_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDF9"/>
    <dbReference type="OrthoDB" id="43142at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856121" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="339" mass="38841" checksum="9A4E0A0B9181744F" modified="2009-02-10" version="1">MNSLNIKCTLLCLCVTRVLGFSPQLITWTATLDLQQTTSLRSKAIESALFVTPRREGDKLSKSSRLRNFIHRFDTISAAGLDPEQVQIAGLFGRIKKIHNPRTYLILAALAGFRWDWCFRNPYYWFAVGFCIKWYRARYVYKIPVWDRQPNWNNIITSKEQEKDLKAFTCKKCGSTIFIAKTREFFFEGNTGIGGLGCFSCGAKGKENFVMDRDRILEDVADEDDYFEYERPLDFVSRAERRKILKEAQGDEEKANELLVKRSASDTINDEVPATSSSSSDVVDTNASAEESNSNITEVETPKKRKKNKKHKKDSKPKESEKQPDLSDDDLDFLDMDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEJ9</accession>
    <name>B7GEJ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma-70 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_17029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185497.1">
        <property type="nucleotide sequence ID" value="XM_002185461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEJ9"/>
    <dbReference type="STRING" id="556484.B7GEJ9"/>
    <dbReference type="PaxDb" id="2850-Phatr17029"/>
    <dbReference type="GeneID" id="7199402"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17029"/>
    <dbReference type="eggNOG" id="ENOG502QVXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_1"/>
    <dbReference type="InParanoid" id="B7GEJ9"/>
    <dbReference type="OrthoDB" id="206108at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06171">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.601.10">
        <property type="entry name" value="RNA Polymerase Primary Sigma Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF47">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA polymerase sigma-70" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="37872" checksum="B6BCD04B3A795D7F" modified="2009-02-10" version="1" fragment="single">DSIRSYIKTMCNHELLNKNEEIILGREVQVLIQYEATREQLEAELLRPPTYQEWATKIQPDMMVPDLKKQIRRSLRAKAALTESNIRLVVSIAKRYQHRGLSFQDLAQEGILGLTRACEKFDPERGFRFSTYASWWIKQSIMRAIADQGRTIRLPVHIHDQINALRKVERELKAELGRDARLEEITEKSTLTAEKIEFLNRVSQQDVSMEQELRTSKSKGSSAGLGGPDGGLTLGDVMGDPEAQPAEEASYQMLKDDISRLICTLNSREQAVIRMRFGLDDGKAKTLEEIGRRFSVTRERIRQIESRALHKLRQPYRNHAVKCYVKDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4G0</accession>
    <name>B7S4G0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999285">
        <property type="protein sequence ID" value="EEC42567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176444.1">
        <property type="nucleotide sequence ID" value="XM_002176408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4G0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1488"/>
    <dbReference type="GeneID" id="7204973"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1488"/>
    <dbReference type="InParanoid" id="B7S4G0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="947"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129175" checksum="74A62D469F4A7C48" modified="2009-02-10" version="1">MMEERYLFLVSRQTTAAYRAEFGKPTLSPSQGNVELGTSVPRPITLPTLFVLHKVSEVSKETFIGLCSASLEAATTILLTTGIENPLVLQGLSLLARSDITHSSNTATKVVEGSEPVLATSTGVGSKKEVRLVTAKDLKYSGRPNPGTLPTRLPSPTQDLTRLSSPTQDLVGYPFQYGYRYTDNVRCKRFRSFTRHGDATPVPIKLRMGHQQLLRYLLLWIRQLSHDKGGSLSNYELISLMKEDFSLFRRSPSIHLSNAVPTPSSQSSTPSTMVGNSSRSAVADFKRGVKRDKTHYPVLKDDRYWDNFYRTFVVTAVSHNVDNVLDPAYSPTNTDEILLFREQKKFVYSALEHCLQTDMGKNIVREHAFDFDAQTVFAKVVKHYTESTPAKISSGTTLSYLTSAKYGSSWTGTAEGFILHWKNHLRIYNDTVPVTEKLPPQLCLSLLESSVRDVSELRQVNTTANLDLAKGGSPINYENYLSLLLAAATLYDKGNNFSNSRSPKSKRSAFVTETTFPDDEYGVNYDIDLSPSILYEANTHNRRAGDQNRDRQSNVNRERPYIPREMWDKLSDDAKEILRGMSSPKEGNASANSKSSSAFHANSHSLTDTGHPSSTDESLHENDNDKFHDCGNDTELLAHLTDRSSNMANGDIRKVLASASSYKQNSKNSLQSNMLEYSISRHSVAETTSSLIDRGANGGLAGSDVKILNKTGRSASITGINDHTLPDLDIVTAAGLVESQHGPIIVILHQYAHHGKGKTIHSSAQLEYYKNIVEDRSRVLGGKQRIITLDDYVIPLHVRQGLAYMDMRPPSDAEFDTLPHVVLTSDVDWDPSIIDNEIDLVTDWHDATQDLPSDPYVEPRFNSTGEHQHRHVATFDIFSSSDFVHRSTAIDNILSSNQHDMTRNSHNYEALRPCLGWVSANTVQKTIMATTQFACEVYNAPMRKHFKSRFPALNVHRRNEAVATDTIWSDTPAVDNGAKFAQLFVGRRSLVTDIYPMKTDKEFVNALEDNIRHRGAMDKLISDRAKAEISKKVSDITRAYHIDQWQSKPNHQHQNYAERRIATVEANANNFLNKTGAPNSTWLLCVSYICYLFNHLAHESLHDRTPLEILNGSTPDISVLLQFHFWEPIFYRLEDPTFPSDGTEKKGPLCWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4I8</accession>
    <name>B7S4I8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999293">
        <property type="protein sequence ID" value="EEC42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176477.1">
        <property type="nucleotide sequence ID" value="XM_002176441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4I8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1518"/>
    <dbReference type="GeneID" id="7205107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1518"/>
    <dbReference type="eggNOG" id="ENOG502S6KT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478806_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4I8"/>
    <dbReference type="OrthoDB" id="42678at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002863542" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="180" mass="19489" checksum="82192C8B1554E5F6" modified="2009-02-10" version="1" fragment="single">MKLSCLFALMAPLLCASQGTTCACEAKELEFSIDCANEALLLETLAALIVDDCSTDCSSAACYKNFLIVQSHHDFCLHDDVPPPVEDAFHDFEEVCEHCSITRKRDPNLSNCPVAACDTRGDVAYQALLTEGCVSACSSSTCASNYQILRSEHDNCDEGTVSESAETGIHDLEEICEAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3H8</accession>
    <name>B5Y3H8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_21030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185659.1">
        <property type="nucleotide sequence ID" value="XM_002185623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3H8"/>
    <dbReference type="FunCoup" id="B5Y3H8">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3H8"/>
    <dbReference type="PaxDb" id="2850-Phatr21030"/>
    <dbReference type="GeneID" id="7204611"/>
    <dbReference type="KEGG" id="pti:PHATR_21030"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3H8"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="44450" checksum="220375BA46D94F17" modified="2008-11-25" version="1">MVTPSPKASAGDIATFNVLHGFPEALVRGMRSSFLSDADYHHLTQCETLDDVRLNLTESDYSDALADSATMTPASLQKAAIEKLVTEFQYLRSQSVEPLSTFLDFITFEYMIENVMLLLKGALSGRDINELIEQCHPLGMFKESTMRSIPTFENSSRGYADLYQTVLVDTPVGPYFAMFLQESSEHRDGDSRNVLEEVEIEIIKSSLIKYWLEDFYQFAMKIGGDTSQIMGELLKVRADTNAINITLNSFGTPLNEPSMRSSDRKRLYPSVGHLYPAGTTMLIDVQDEDELGRVLELFPQYSAIWSIHASGNGDKSIDDAFYERDVQQLELAFESQFHYAVFYAYVKLKEQEIRNMVWVSECILQQQKDEINKFVPVFSYHSPWRDGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3K5</accession>
    <name>B5Y3K5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185853.1">
        <property type="nucleotide sequence ID" value="XM_002185817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3K5"/>
    <dbReference type="STRING" id="556484.B5Y3K5"/>
    <dbReference type="PaxDb" id="2850-Phatr46720"/>
    <dbReference type="GeneID" id="7204627"/>
    <dbReference type="KEGG" id="pti:PHATR_46720"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353554_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3K5"/>
    <dbReference type="OMA" id="KANDVEW"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF47">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="696"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="795" mass="89902" checksum="F0A4B84C8B360289" modified="2008-11-25" version="1">MTTSADRKSAWRVAGIVLVLLIGSCSTIQKRFFVLSFSPQSQNIIPRTSRWNLDHESLHTFAKEHARTYLWASNSGDEDKAPQNEEASKNLPKRKKKKKPGSRAGEPSLDDRKKNKEELVKEIGERMRDKNKKPIGETHDNSNSLLDKLNPFKAGQNLRKQLDTAITSISSVAKTEKRTMYYLDDRLVDGTNVFSERTLERLDQDDFVPEVLVVGATGEVGRLVVRRLLLDGRFRVRVLVRDLYTKTLNMLGTGVTYCQGDLGNMDSLEYALTDVDKIVFCASAPRPDEDQFQQRFQDFMKETLESRDDSIKDIFDSKANDVEWEQLESVLELRARLAEQVDCLGMQNLVRAYQHVRHADYGTSQAAKRSLFKFQSRPDDFNLFALDDVGDDFSETAEGERKDYTSNYSYNEEDYDEDDDMDEGEYEDEYADYDEEYDIVGLEKRQDSSVKTQVQWIRNKFRHAVFVGRVPKATSGNAGGEAAITSSRLRAREDPDNGIDLSNGFAGFICRVCSDGGTYEAFVRTRAFYTDGIEYVCQFSTSTKPIGRNKSKNKFVTVRLPFENFTPVRTASSKLVGQDESIPQFRGGDVRNIGFRYRSSGNELKNKLEQSERNSFYLAFSYIKLYRAQPEPEFVYLSDARIPPVVPNGMVRHEARQLLAANGNESSTGSYQILSDSALWSSTRDKTSRSPEETYYKYRGEEILKQSGLSYSIVRVCGFNESPSGEASTIDLQSSTNDLSAVSRDDVARVCVSALLDPNALNKSFYMGKKKGQKSSSKDEDMASKFGQLSADAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3R7</accession>
    <name>B5Y3R7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_46782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185703.1">
        <property type="nucleotide sequence ID" value="XM_002185667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3R7"/>
    <dbReference type="SMR" id="B5Y3R7"/>
    <dbReference type="STRING" id="556484.B5Y3R7"/>
    <dbReference type="PaxDb" id="2850-Phatr46782"/>
    <dbReference type="GeneID" id="7204538"/>
    <dbReference type="KEGG" id="pti:PHATR_46782"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029471_2_0_1"/>
    <dbReference type="InParanoid" id="B5Y3R7"/>
    <dbReference type="OMA" id="QHRININ"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF11">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="39964" checksum="7018E03BE7DF902C" modified="2008-11-25" version="1">MIDDNTSVGSKNWSVFKQTQVRYKRQVDAPDRLDDVDDFVDFGRADGRIQRIVVPKSEDFAFYKGPVYGVNEFPGFLYAPQALSELLQAELSFLAVSSFCERPHSTNIDKVPCKNWEIDDGQRCMWEEWKLEQMETYTEASQMTSKSSSRPKYRSFRKLSWATMGYHYDWNTRSYNEKAKSPMPKLLERIAEIFAATSLLVDGQDPCFTASASIVNFYTPKSMMGGHRDDLEHALDKPIVSISLGRPAVFLLGGNTKDDQPVVAILVRPGDVMMMGGASRLRYHGMARLLPTTGLPSVEKDRVPDWDLQLSAKSLGKEAELSQFEEDDRRALASFLEQHRININVRQVYSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4U1</accession>
    <name>B5Y4U1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186354.1">
        <property type="nucleotide sequence ID" value="XM_002186318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4U1"/>
    <dbReference type="STRING" id="556484.B5Y4U1"/>
    <dbReference type="PaxDb" id="2850-Phatr43936"/>
    <dbReference type="GeneID" id="7204167"/>
    <dbReference type="KEGG" id="pti:PHATR_43936"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268482_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4U1"/>
    <dbReference type="OMA" id="KIVAVCP"/>
    <dbReference type="OrthoDB" id="49561at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="464"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1223" mass="136630" checksum="505AFC1B8D612619" modified="2008-11-25" version="1">MAGSTSIMPSPPRNPPTKTQQLWRCDVCHTASFASFQEACIHEDLCREEQTREGEEHQNHEPPTHANPKRHPFFGGVPKPRGASTTPAFVTAHKMKRKPSKANLSLPHKVVERAARKDVSLTTEVTPVRHSTPNPRTSSLDDGIGKRSHPPLDADMDSVGQIYDVKDYDTHVPTSKSRAKKTCKHKTECRLSPLVFGKTKEDSKILMAEQRQAEFQAKRRLKTLKDRERQLKRQRAADDATGSTASSHDPTAKQYTNERHPCNQQKNVVAHAARFPTPSHVIPADRKNSQSASDSKAPYSWLSLDALKQTRAAISQLQYAGCDRNMSENFVQTKHSENEAKLRLLPVDGNSFAGNFRPKDPIKLTLQAHLVPPLEPASNTDTSLWSDRYGIRRLPEDLCGASIENAALDLAKFVQEWKLERQKAHECRAENQRRFQKNVSRANKVVYKDDRDLWEDSDEEGPSLPSLCLITGPVGSGKTSLVHAVAQQHGCPILEINTTERRGASALRKTIEEATQSHSTMDLLHTHQANVFATAKKGPNTDCNDKSVNSMMRGSTLTVILIDEVDLLFEAQGDNGFWSALCDLQKRSKCPIILTSNRFPDCLNSPSFRFHHIVVDMPHPRECMSKLRRILENERFSLCRNTSDSSLEKMLLELAELCRSDMRRMCLELQLFASSDASSFLEAATAISIEPEETSFASLSSRSPKIDAIQPSCVPSDTFSFVTVTGKNFLSLVASPSLGNGGFPVGVKVGDQVCFSSRIMNDSTILSVVPPCRLPLCVGSCGMVEGCNNRSLESRYAPVVVYSLAELGCISTTFGHLIVDELTLGTISSLHTICNLEYCLPTPMKTEQNEDEGGGLEDEQHNITSIENVPSSLDCLMLPNTLPRVFEESKLPARLLKEGLDAWNLKYELSRAVENYRPVLPALEMEEASFDAEINSDSRLLEDLGSLSTPFLSGAVRGFGFDLTEAFPKYNNEKSKPPPEDRLFSLGWKEDAYFFGGSESYVILPSRVEKRRLLHYSLCSEEGVGLLTGFSAHHEDEHSAAGTGVDVFISEQENIVLFDQTQASFLALPSLLRTRMRTQLFKDKESHQCLYERKRKAYFDLTIDRLVKTVFTKNAGRFLFSRNLTGAMVDGIQDSALVLDYLPTLRCIALYENEVNYAHETDCYRQTTTSHGISRHTRRSKKRDMRNHLELLATESDSNFKGLTPKQLSDFLVASTLNFWPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4U4</accession>
    <name>B5Y4U4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186356.1">
        <property type="nucleotide sequence ID" value="XM_002186320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4U4"/>
    <dbReference type="PaxDb" id="2850-Phatr43939"/>
    <dbReference type="GeneID" id="7204169"/>
    <dbReference type="KEGG" id="pti:PHATR_43939"/>
    <dbReference type="eggNOG" id="ENOG502SK3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122015_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4U4"/>
    <dbReference type="OMA" id="DKEPMGG"/>
    <dbReference type="OrthoDB" id="196775at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841266" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="27266" checksum="4C746EDA77C59F33" modified="2008-11-25" version="1">MKLSFNLIVAAVAISGASAYSVPSRSSLRSLGQKSVSAAPRRQVGSASLKMEGKYFGFMKGSKFSFDDEWEGVEIISEVAIEKRLNKDGLRYKMNRTEKEADEVGRLAGLPGITLNLPIIGETYLGPPKVASIWEALGFTATSNNEARQLEKMKAIEGARNAKKGVLNGPGKEQRGEWLKKYGYPRLVGSGGIFYADQLSTDKEPMGGFNMGKSGSIWPVPDVVEAGQYGGAKGWGMKKKGPAVDGLPAEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Y5</accession>
    <name>B5Y4Y5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory proteasome non-atpase subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPN10</name>
        <name evidence="5" type="ORF">PHATR_54173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186088.1">
        <property type="nucleotide sequence ID" value="XM_002186052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Y5"/>
    <dbReference type="STRING" id="556484.B5Y4Y5"/>
    <dbReference type="PaxDb" id="2850-Phatr10321"/>
    <dbReference type="GeneID" id="7204191"/>
    <dbReference type="KEGG" id="pti:PHATR_54173"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Y5"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="395" mass="41547" checksum="59B4055D23573E2E" modified="2008-11-25" version="1">MPLECCMILMDCSEYMRNGDYVPNRLDAQKDATNWLVDVQINSHAESTVGISAGSNLLMSPTRDVAKILSSIHTSTFAPVTGDIPSAVQVASLALKHRQNKNGSQRIILFVGSPLDHLDDKLLQKAGKQLKKNNIAIDVVVLGQADTNTPKCQILVDAANGRLEDTGERTCHVVTVPTGTLPSDILASSPIVTGGGGGAFAAAAGSGGGQGSNFDDFGGMDPNMDPELAMALRVSMEEERARQERVSAAAAANAGDSAGADEANNETANDPPPMDAEEALLQQALAMSMNENEPTNIMEDAKPAAAAEDQMDVDDDAEMQIALQMSAQQQDEAGASGTAAATGSNEFQDPAFVQELLGSMPGVDPNDPQIQEALRKAAAEKRKGDEDQANQKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5H8</accession>
    <name>B5Y5H8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_44146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186473.1">
        <property type="nucleotide sequence ID" value="XM_002186437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5H8"/>
    <dbReference type="STRING" id="556484.B5Y5H8"/>
    <dbReference type="PaxDb" id="2850-Phatr44146"/>
    <dbReference type="GeneID" id="7203896"/>
    <dbReference type="KEGG" id="pti:PHATR_44146"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978135_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5H8"/>
    <dbReference type="OMA" id="ARICHDS"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="285" mass="32917" checksum="417043884183847E" modified="2008-11-25" version="1">MADLYNLLDEIKDAEADDNNNDQTARRGETLEQQEEERDWDDTDAPREQIELPNIRSSRFDEDGSIGHGDDPHDEPDFALEDVGESSSLAEDALLAELPYTKLKTWWQQERQSPELLPYNEELLQGLIRSVEERLEMENAELSSNPNLQALFASLVRMDTERVQYVVTDLLRTRLEKIEKHPLYMRRMADRMSVAELEFLKGYGTILERHLRTTVLDHIVEDDFAKLDETHMIDEPDTETYVFARICHDSPVLVEQQSLAPGTCLIAPYHKLHESITDGTIQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5R0</accession>
    <name>B5Y5R0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_18793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186508.1">
        <property type="nucleotide sequence ID" value="XM_002186472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5R0"/>
    <dbReference type="FunCoup" id="B5Y5R0">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y5R0"/>
    <dbReference type="PaxDb" id="2850-Phatr18793"/>
    <dbReference type="GeneID" id="7204126"/>
    <dbReference type="KEGG" id="pti:PHATR_18793"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_1_1"/>
    <dbReference type="InParanoid" id="B5Y5R0"/>
    <dbReference type="OMA" id="DHTQQNE"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACI65978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="84459" checksum="A0FB92600C43F305" modified="2008-11-25" version="1">MTTPLSSRLLAALRASRPASRRSALRSTQIGACMLPRNSPHRGFRTSTQAMAEGISQSTERPAATSTADVKDKPPAPDVRVQASEPEKQPEMLEFQAETRQLLDIVTNSLYTDKEVFLRELVSNASDSLEKLRHLQATNAMIVDPDLALEIRIELDEVTSTISITDTGIGMTRDDMIQNLGTIARSGSKQFVKELERQASGSIPDPARGIIGKFGVGFYSSFMVGEKVEVRSRSAQHDDEPSRVWTSEGQGAYSITDLPEDVRQQRGSSVVIHLKEKHWDFVDESRIEGILKRYSNFVNFPIYLNGNRVNTLEAIWTKEPKEVEEEAYSAFYKYIANAIDEPLDVYHFRADAPLDVKALFFIPSFHSEKFGMERMEPGVSLYSRKVLIESKSKDILPEWLRFIKGIVDSEDLPLAISREKPQDSALIAKLRKTLTRKFIAHLTKMAKKDRPKFLDEFYREYSFFLKEGICQEYEFQEHLAKLLFFETSRSTDADMVSFDEYVGRMRPEQKEIYYLMAPSREAAINSPYLETFEKAGVEVLFLFSTIDDFVMANLELYEGRKLVSVEKSDIDLKDLMDADADKADEGEEIFTADKELSATEQVEFCNWFKTELGSKKISSCTVTARLSSSPAIVTDSESGAMRRMMRLVDTSEGSRDSVPLPKQHVEINPKHPVIVGIHDLITKEPTLARVLAEQVYDNCLVAAGLLDDSRSMLPRLNDILVCVVNGAKAKHGSGSKEIVEPEVVAKTDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPJ6</accession>
    <name>B7FPJ6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176725.1">
        <property type="nucleotide sequence ID" value="XM_002176689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPJ6"/>
    <dbReference type="PaxDb" id="2850-Phatr42790"/>
    <dbReference type="GeneID" id="7196405"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42790"/>
    <dbReference type="eggNOG" id="ENOG502SAK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1647031_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPJ6"/>
    <dbReference type="OMA" id="FIIPMAQ"/>
    <dbReference type="OrthoDB" id="5645at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854851" evidence="2">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="161" mass="17706" checksum="FE67C70FB730A096" modified="2009-02-10" version="1">MKFLVLFYAVISVAFSVDGFAPRTPKTISPVVDLQKAAAGAFAAFTIATSSLSAPAADALTPVFSSSNVVAEKVTREGMYGEYTTDLVQTYDDARSTFKDAKETKSKKGKYTALLAVLIVGSFIIPMAQYFWYVRDDDSTDKFFGQKAPEPEEPPKKKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ26</accession>
    <name>B7FQ26_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_9634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177319.1">
        <property type="nucleotide sequence ID" value="XM_002177283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ26"/>
    <dbReference type="STRING" id="556484.B7FQ26"/>
    <dbReference type="PaxDb" id="2850-Phatr9634"/>
    <dbReference type="GeneID" id="7196556"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9634"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_1_1"/>
    <dbReference type="InParanoid" id="B7FQ26"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="109"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="480" mass="53753" checksum="CE2B848F826D9B46" modified="2009-02-10" version="1">MTSPDVPLPRVKEGRAVPSTRVGRAWGFAQLGVGLAIGTAVEGASRLWGSPSKTAGNGNGSLVINDHNADRLAASLCRMRGAALKMGQMLSIQDETLLPPALTRALHSVRQGADAMPRYQLMAQLESQWGANWRENKSVVSFDETPLAAASIGQVHRAQIKFDNQDSDENGNTSVQDVVVKVQYPGVGNSIESDLRNLAMLVKVSGLAPKGLFLENVIRVGQEELRVECDYQREKTNQKRIRDLVHTDPVLQANNFVVPYVYNEWTTDEILVSEYRPGGTIDKVSNLSQEERNRIGRAIMYLTMKELFVWRFMQTDPNWGNFLYDVGSKTTSLIDFGATREYSKEFVDGYLRIVWASANQDEATLMEQSHRMHFLTGDENEAMLRAHKLSGFTVGEPFWKSEAFDFQGSQISSRMGEHTSVFLRHRLTPPPEEVYTLHRKLAGAYMLCIKLGAKIVCRDMLEEIVRDHIFEDGLPPPVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG4</accession>
    <name>B7FQG4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177398.1">
        <property type="nucleotide sequence ID" value="XM_002177362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG4"/>
    <dbReference type="STRING" id="556484.B7FQG4"/>
    <dbReference type="PaxDb" id="2850-Phatr43051"/>
    <dbReference type="GeneID" id="7196246"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43051"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1117560_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQG4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="27818" checksum="6DE03DBC22536131" modified="2009-02-10" version="1">MSVSSATTSSNESPLSTFSFPRTGKRGVPQQFPRRLYEMLDSETKLIQSTPDHPKIIAWSDSGTAFRIFDAVEFAASVLPKYFRTRKFSSFQRNLNLYGFTKVRRGPDADFYAHPSFLQDTPDGLLNLRKMSPASRRRLVKESKASTPTATDRKTRWEGSRSVSPSPPTSDSSDWGSPIQSSKPAVDLLTRSMPQWTNIPSLAPESRNISFNAVRKPILPPIRKVSMGDRGRLDLLAFALETQAFAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG5</accession>
    <name>B7FQG5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_43052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176868.1">
        <property type="nucleotide sequence ID" value="XM_002176832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG5"/>
    <dbReference type="PaxDb" id="2850-Phatr43052"/>
    <dbReference type="GeneID" id="7196848"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43052"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392067_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQG5"/>
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        <property type="term" value="F:potassium:proton antiporter activity"/>
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        <property type="term" value="P:regulation of intracellular pH"/>
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        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="281"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="10">
        <location>
            <begin position="176"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="704" mass="78054" checksum="1812F187463BEED0" modified="2009-02-10" version="1">MNAARCLKGFGTAVALLSTFAILFLVVNWNANVKRTSFIHEGSAHRYRDDKSWASIPLDDYKNDLVGEQSVDDDITRDDTCRKYLMNFLNGTTDAKDECEGMYNAWQAADCTDDKNLQHLSRKHKAADGNVTDDDVLIDDFYENWECCTSISNFYNRHCQDPQLASGKLLGIVSVLVVCGLVKSALRFANLPWIPDAGACIFVGSVVGVFLRLFDHEAVRDELTFNNDLFLQVMLPPIIFEAALSIDKRAFRRDLFPILTFAIFGTGFSALAIGLVTYYLSGIGSGIALPFLDSLLFGALMSSIDPVAVLGILSGVGVSQGDTLYILIFGESLLNDGVSIVLFDSLVRHMGDVDVVDQANVRDTMVHFFTVISGSIFIGAGCGVFCTLYFWLLHGKHSAVSEVALFFAWALIPYYIADGLDASGIISIMVMGFMLDYFVVGGFQSEGAEWREYMNSRMEGAGSHPVEPYFDRIKAAFNLAFSGKGHITDHSRQHVGFVAEVISSIMETAIFAYLGLFLFNDKNWDLKLTSAGLFGCISSRFVMVLVLAALINACVWLDLEGFLTRAWRTLVRRNYSSANYYMDEVKSYLDPRTQVILFAAGVRGAVSYALVQNIPVYDSVTKYGSHYKGQLKAMTSATIVIILFVFGALTYFTVQRPSQVRRSQPLTDRLMEGENPTEHDLDLQENHQNVSNSITIEIEGRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQI4</accession>
    <name>B7FQI4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177407.1">
        <property type="nucleotide sequence ID" value="XM_002177371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQI4"/>
    <dbReference type="PaxDb" id="2850-Phatr43067"/>
    <dbReference type="GeneID" id="7196709"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43067"/>
    <dbReference type="eggNOG" id="ENOG502SQ58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232033_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQI4"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050245">
        <property type="entry name" value="PrsA_foldase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE HP_0175-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="195" mass="21698" checksum="FD68E957FC269A06" modified="2009-02-10" version="1">MLLLTLLCLHGAQGFSEIKNPLDRIQKDYLALTRRVTARHILLPPSADLALALKQKIRNRVNEDGVYVIDAFEAAAKKFSRDETTNFRGGLIGELVPQGYCRSVELDQACFSVRLGEIEGPLESDYGFHLILVSERTNCPKLDGSKTKLVRDGKVTRLVEGEQIGRPDAKYFSQVLAFLAYAFLFGGILAEILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQK2</accession>
    <name>B7FQK2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177418.1">
        <property type="nucleotide sequence ID" value="XM_002177382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQK2"/>
    <dbReference type="PaxDb" id="2850-Phatr43083"/>
    <dbReference type="GeneID" id="7196867"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43083"/>
    <dbReference type="HOGENOM" id="CLU_1100293_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQK2"/>
    <dbReference type="OrthoDB" id="10540535at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852527" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="27304" checksum="C756E1B47BDC39CB" modified="2009-02-10" version="1">MILHSVLLTLSTLVVVSALDVEISDFTCDNSYPMTTTLEMSCNGTSRCTFGETAIISGILTYSGVDQTGIQNNQAYVSSELAFPTMNFNILNMMKIPLCDESLVADSGNTNECPGDGTFSYSVYYNLPKSGTESASWMASGWTGTGYIEIYAEANVNMMIGRCSMDLQTYVTASEEKGYLRTPSAATAAGISLAALAALSLLCFWCCCCMGRRKSKTSHEGEETTSFTRMNDEIPYSVNAADKKSGLKKALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQK3</accession>
    <name>B7FQK3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176886.1">
        <property type="nucleotide sequence ID" value="XM_002176850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQK3"/>
    <dbReference type="STRING" id="556484.B7FQK3"/>
    <dbReference type="PaxDb" id="2850-Phatr43084"/>
    <dbReference type="GeneID" id="7196868"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43084"/>
    <dbReference type="eggNOG" id="KOG4749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532640_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQK3"/>
    <dbReference type="OMA" id="SKEACIY"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="512" mass="58183" checksum="A4CBBC6D4C1234BE" modified="2009-02-10" version="1">MIASDWTYAGEGGKHVIFAHRSSTANALNPEWRGCLLRIKKDYLKMAGCFKDLPNSVAIPEDTCLYFRSCILPKLAPYVDAPQSIRLHWSFVAVIREASLTSGKIPEGRLKDWSLVSAESMEKPMYPTASLVPDYRLQLPSSVNFSKSRSITVEIKPKAGYRAYSPLVHPTTRFKYRYTRYTFIQWIKTGNVSVPSNDHPAYDPVDLFSQDAQTVERALLSLLREPRNNFIVWHGRESMMTLKNGEPTIDDRKLSDALPFNGLQGGEEQNFLIRILTSVLHTEPFLQDLLQLQNLDILDADGAVLVYRRLVWLCNGSEDEAEILIDRLDSLVSQTLGEAPPSLNEHSPIPFPSKSNKIDLICHAIQTFREILLSQEPIIPNKQIMDSFRKRTVGIVETLDKEECVYLLQNWMLSLAMCDISFFVSFCFEASKDIDVLHSGRCAVTVKSTQKDGLPGLVEIAGEDVFYQIRVIDTDKKPARKLRYRQRKEESLALFALWECRKDEPEEGRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQM0</accession>
    <name>B7FQM0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L19, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_9259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177428.1">
        <property type="nucleotide sequence ID" value="XM_002177392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQM0"/>
    <dbReference type="STRING" id="556484.B7FQM0"/>
    <dbReference type="PaxDb" id="2850-Phatr9259"/>
    <dbReference type="GeneID" id="7196724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9259"/>
    <dbReference type="eggNOG" id="ENOG502S8N4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_1_1_1"/>
    <dbReference type="InParanoid" id="B7FQM0"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="92" mass="10533" checksum="65A27E027F6EB631" modified="2009-02-10" version="1" fragment="single">RVGDAIEIEMVSDGGVKSDDTDLIRGVVIGITRRALDTTVLLRDVVFGEPIERRVPLHSPLLRSLKVLEENFIYKGKRKVKRAKLYFLRDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRI8</accession>
    <name>B7FRI8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177048.1">
        <property type="nucleotide sequence ID" value="XM_002177012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRI8"/>
    <dbReference type="PaxDb" id="2850-Phatr42506"/>
    <dbReference type="GeneID" id="7196686"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42506"/>
    <dbReference type="eggNOG" id="ENOG502S8SH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1317685_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRI8"/>
    <dbReference type="OrthoDB" id="5007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854923" evidence="3">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="397" mass="42259" checksum="3AF2792C56E5A4F2" modified="2009-02-10" version="1">MSKLSFFVVALVVAMAQAFVPASQIRTPATFVAKETSAFALNMAEDTYWEGEYPPSKVLGPIMSKMPSGLLGMLSLVFLGGCAYSIAMSNVLVQVPGAVENGSWVKWYYVAGSFGGPLAWGTHVAAWIQHTVGRLSRAFLATIQDIHSARHGLYRSPSQCGPRPLQDQKLSQKSSPTCRESSAQNNSTMVRLLNAARWGASWSVVVVLLLGQVSADRRTLLRIEHAQTPATGNRVTSMEFGRRVTAVKEAPANDIEMAFRELAESDAFSSFSVPSMSMSMPRAFSLDYGLPPTLPPSLSTIQINSVAPKLLVIGASEAAMASPTSSAGVAASIGARDEPMVPSQSSYTQGASIAVVGAFLALVVGAVVYRRRRASRSSYGFLVEGTSSPASTVAFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRM3</accession>
    <name>B7FRM3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_9180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177072.1">
        <property type="nucleotide sequence ID" value="XM_002177036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRM3"/>
    <dbReference type="STRING" id="556484.B7FRM3"/>
    <dbReference type="PaxDb" id="2850-Phatr9180"/>
    <dbReference type="GeneID" id="7196083"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9180"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FRM3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="84"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="382"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="671"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138430" checksum="E85AD24F8263A5D1" modified="2009-02-10" version="1" fragment="single">PLLNASLFSKLCFMWPYPILKLGLERPLEDRDLADCIETDTSDYNRDYFNRIWREEQGRNPKNPSLHRTLLNDFLRTTWFVQPLMMLAATAKVLQAVALGLLIESFEKETEDGYYWATAIVVSGIVILFEHHHVFLATWRKGMRLRISCVAAIYDKSLRLSSTHQDTSASYGRIMNLASNDVERFLLASLFISYLWWAPIQSMAILVVGIVLLGPAFAAGFGLLICVFVPLQFYLSGKFAFYRSKIAGITDKRVTFVSQAVRGARVMKMSGYEHRFLERIQDFRREETAQIAKANRLKSYNEALFFSTNVVISLVIFVVHVFSGGVLRPGDVFTVFTLINILQLEMTKHVSLGVMGASECYVSIGRIQKFLEFPELPSMASKHESNTSKNLSKPVLGHNNNITVDFHFGEVTAVIGTVGSGKSALLQALVDELPISAGTFSKHFSTLSYAAQDPWIMDGTVKENITMGREVDELWYTEVVNACGLAMDFRQFRDGDQTIVGDRGVQCSGGQRARIGLARAIYRDADVLVADDPLSAVDAKVGRQLFQEAIMELAVGRGKCVILATHQHQYVHECRCVLMIAGQVECIGTYEECVTASDGRLTAHAADNASVDTLEDPVTEKDALKIDTSDGVEEVDLDPTSIGDDNKEMNSQGVVRTETYLNYLRAMGGVWIGCLLFVLFSMTQTSVLITIASVGRWAERSDSEQSDWDIIGLCIGLGCSVVLFAVVRSLITFRLTIKASQQLHDRMAQAVLRAKVEFFDTNPLGRILNRFSADVGSNDDLLPATLFDFFMIAFIVLGALITTVVTLPFALAAFPFLLIYFYNVRKVFVTSSRELKRLEGLARSPIFAKLSESLGGIATIRANDALVFFQKKFQDAHDAHTRAFFGFMAASRWVGFRMDSIMFLFLAIVSFLSVLFQTKGWFDVDPSILGLSLSMLLQLAGVFQWCIRQSAEVVNQMVSVERVVAFGNIEPEAPLEIEDENIALKDGWPSAGEIEFEQLSIRYRSSLPLALEQVSFKIPSGARVGIVGRTGSGKSTVVQTLFRLLEAEHGRILIDGVDIASLGLHALRTKISVIPQSPTLFSGCSVRENLDLFNLHDDEALRKVLDDCHLTDVIRDLPQGWNSLVAEGGSNFSVGQRQLLCLARAILSKSRILVLDEATASVDRRTDQLLQEALHESFHGGTILAVAHRLDTVIEHDLILVLGQGRVLEFGTPADLLRGNGAFASMVSDTGDSMSRDLRQRAFAKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRN0</accession>
    <name>B7FRN0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hCDK2</name>
        <name evidence="15" type="ORF">PHATRDRAFT_42539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177075.1">
        <property type="nucleotide sequence ID" value="XM_002177039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRN0"/>
    <dbReference type="STRING" id="556484.B7FRN0"/>
    <dbReference type="PaxDb" id="2850-Phatr42539"/>
    <dbReference type="GeneID" id="7196701"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42539"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="B7FRN0"/>
    <dbReference type="OMA" id="MFELITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="36"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC51538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="39365" checksum="61CE51775D451E8C" modified="2009-02-10" version="1">MEIRKRARDQKAGSEVDGRNRRETANGRSVNVSDLYEKIGRVGEGTYGIVYKARNLQTKEYVALKRCIPHNESSDGFPVTTLREIQSLRICGRHPNVVALETVAVSKNGVFLVFEFCEHDLADLIDRHYQKHKKSPFRESSVKTLLIQLLGALDYVHCHHLIHRDLKLSNLLYTRRGVLKLADFGLSRPFSSSGNNAALTPQVASLWYRPPELLLGSRQYTQSIDIWATGCIFAEFLQGMPLLNGKTEADQLNRMFHTLGVPDDLEWPDLPAMPLLQDGTIRLPDRQTSLNTLLDTFAFLSTEGLRLLCTLLRYDPNRRGTARQALTSHYFSDLPLPTTEADMPKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRT7</accession>
    <name>B7FRT7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_18027</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177552.1">
        <property type="nucleotide sequence ID" value="XM_002177516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRT7"/>
    <dbReference type="STRING" id="556484.B7FRT7"/>
    <dbReference type="PaxDb" id="2850-Phatr18027"/>
    <dbReference type="GeneID" id="7197076"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18027"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FRT7"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="16">
        <location>
            <begin position="296"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC50366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="706" mass="74911" checksum="0E2FAD967DAEF9C3" modified="2009-02-10" version="1" fragment="single">MNPPVALESCEPASRAALRRARRVCVKAGTSVVANEDGRPSLTRLGAMTEQIADLVQSGIQVILVSSGSVGMGKRLLRKQRNLQMSFRDIHNNDHYYDSACAAAGQFEMMNLYCGLFASYDITASQILVTQTDFVDESRQRNLQYSIERLLGLGIVPIINENDAVSANMGYTADDVFSDNDSLAALCARHFGAEVLLLLTDVPGVFDRPPTEPDATLLRLYQSQPVAIGEKSSQGRGGMASKIDAALSAVQPGSTCCACVVAAGNDLNVIRSVLAKTPPTTAAVADFVSDTHQDASVAEQTRILATAARTQARKLQALPYGARQTILNAVADALLTHQEALMEANLLDLQAAERDGVSEVLKKRLGLTLQKFDTLAAGIRQISANKDPLGVIHSRRELADNLVLSQVTVPIGVLLIIFESRPDSMPQISALALASGNGLLLKGGKEATHSNAAIHKVIGDAIEESSGGEITRDIIALVTSRGQVADLLSLDDVIDLVIPRGSNDLVSYIKSHTKIPVLGHADGVCHVYVDESAAADAASKLCVDAKTDYPSACNAMETLLLHAATLSNGVAAATLMALRASGVQCLGGPAAMKSGLCDRAAPELKHEYGDLTCLVEVVPNLEAAIDWIHKYGSGHTEAIVCGEESDVGEEFLRKVDAACVFRNASTRFADGFRFGLGAEVGISTGRIHARGPVGVEGLLTTKWQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRW4</accession>
    <name>B7FRW4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lhcf2</name>
        <name evidence="19" type="ORF">PHATRDRAFT_25172</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177870.1">
        <property type="nucleotide sequence ID" value="XM_002177834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRW4"/>
    <dbReference type="SMR" id="B7FRW4"/>
    <dbReference type="STRING" id="556484.B7FRW4"/>
    <dbReference type="PaxDb" id="2850-Phatr25172"/>
    <dbReference type="GeneID" id="7197087"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25172"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_4_1_1"/>
    <dbReference type="InParanoid" id="B7FRW4"/>
    <dbReference type="OMA" id="NDGWEPE"/>
    <dbReference type="OrthoDB" id="39049at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000011">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011977125" evidence="18">
        <location>
            <begin position="16"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC50684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="198" mass="21296" checksum="D34FFBF9B503C27A" modified="2009-02-10" version="1">MKFTVFASLFASAAAFAPAQQAARTSVATNMAFESELGAQAPLGFYDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVAGYLAQEAGWRLGGDIALDGTKFADIPNGFAALSAIPQAGLIQIIAFIGFLETSVMKDITGGEFVGDFRNGYIDFGWDSFDQETKLRKRAIELNQGRAAQMGILALMVHEQLGVNILPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS36</accession>
    <name>B7FS36_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177599.1">
        <property type="nucleotide sequence ID" value="XM_002177563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS36"/>
    <dbReference type="PaxDb" id="2850-Phatr43391"/>
    <dbReference type="GeneID" id="7197128"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43391"/>
    <dbReference type="eggNOG" id="ENOG502SRGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506689_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS36"/>
    <dbReference type="OMA" id="RMEDRFH"/>
    <dbReference type="OrthoDB" id="48212at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="538" mass="60788" checksum="B4114FEB8067063A" modified="2009-02-10" version="1">MGDCRLKIKISLKLLSTSVEEPGGWLVFTKVWSSDTTICEVCDEHLDDAVVSINNLLRRREGFSAAHLWDCTSYPPRDVTDWPLKIFSQTQGSHSKTLFAAGWYPSGSLEVLPADESPQLASRSQYDDVQYNVQQGENSIVLHKKGKLAALTPTPTENVKPSELLRSVTSRFDRDDEKHRDLDAKAAQLRCENLQLAKSKQKARNQRLEIRIRNLENAGKQKNRSVSSQVRNMLIKSRATGAESLKMQDRVYFYCILVDDANEMCEPKEEYRYYSPQDTIGKICSQFTLPGKVSELLIWRSAESKDEARGDPYRRLPSLMRIYEAIGANYLTGINKILIRFYRAGIDEATPSIDNIAPIEIQDDKTKGSLIGSIPDINTTVTSHADVTAASQTKSSCEGQIDERLTLSIQALDEKSIKRKSSVTAQKVLQMKMKSKARGDSKRVKIEDRFFLELVIATETESNYRCEILPVFVALTDNLERIVRDFVDHPGGCKGWEILVPNADSSVFLRGTQTTMCLKELSEKGIIRQFNRIVIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM6</accession>
    <name>B7FSM6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177692.1">
        <property type="nucleotide sequence ID" value="XM_002177656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSM6"/>
    <dbReference type="FunCoup" id="B7FSM6">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSM6"/>
    <dbReference type="PaxDb" id="2850-Phatr41745"/>
    <dbReference type="GeneID" id="7197296"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41745"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSM6"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="39500" checksum="8918C0A6760D6BA7" modified="2009-02-10" version="1">MSAFKRAKLDDLPSEQIIGTHSGTFQADEAMGVFMLRQVSKYRNSKVVRSRDLEVLDKLDIVIDVGGIYDHTKLRYDHHQRNYDERFDAGKEGTAARCTKLSASGLVYRHYGKQVLKAYYPDLSDDYLQLAYDKLYNSLLEALDAIDTGVEMAPDGTELVYKDTTGLASRVGRLNPRWNEVDESGNTPNHDERFEKAVDICGQDFLSVMTVIVESDIPARDFVERALLKRHETDPSGEILCLESGGLPWRNHLYELEKIHAVEPIVKFVLYTDVSGMWRVQAVTVQGKAFENRLSLPAEWRGVRDQDLESVTKISGSRFVHAAGFIGGAETYEGVLKMAQVALTRQKKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSP5</accession>
    <name>B7FSP5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_32809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177699.1">
        <property type="nucleotide sequence ID" value="XM_002177663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSP5"/>
    <dbReference type="PaxDb" id="2850-Phatr32809"/>
    <dbReference type="GeneID" id="7197308"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32809"/>
    <dbReference type="eggNOG" id="ENOG502STFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_919692_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSP5"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="217" mass="24431" checksum="B8D4EFB3A30366FB" modified="2009-02-10" version="1">MTTPKADEGEASCRATSRKNRVYILRDFLESAYGDYLVPGDVVLDIAGVKGDLSWLLRNIHGVDSVVVDPRVTRHEHILRSVEYLRRYPKEALERAVSGLPSHQPLAALMPRCQHISDFQIPQHLRILVDDDLVNAIRNVRGNEDSCPIVWEEYWAAATRKALETNTQGYREARRRTKQQIVDADEALQIILQTRLVFLVASSLPSSPGAFSTTAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT55</accession>
    <name>B7FT55_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177781.1">
        <property type="nucleotide sequence ID" value="XM_002177745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT55"/>
    <dbReference type="STRING" id="556484.B7FT55"/>
    <dbReference type="PaxDb" id="2850-Phatr43695"/>
    <dbReference type="GeneID" id="7197238"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43695"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303383_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT55"/>
    <dbReference type="OMA" id="VNAWAKS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118598" checksum="75CDC664E90AE14F" modified="2009-02-10" version="1">MVSNRRKRKILGCFLLFATPIDGLLGVTSAPSLTRKKRRHSKWSFLTSPSSTTRATLRSGKSSWLEAAPHRQVNTNASSPPTESLSSSSPATSFINTNSPTSSASSDARHTDSPLSQIYEDDEHPRAPRPPPSSFSRNEDWLESVTGELLDLDVYPLGKLTDDDVESIAGLMAAWARRKSVTAALTVERLLKRVVDDLKEGNQRVHVTTRMYSCAIDAWAKSGVEGSCERAAQIHDTLVQHYQSTNDPLLAPSVMSFNTVVNAWAKSNHDDAPAKAEAVLEEMIQAYRNGNEALKPDAVTFSTILDAYSKSNKPNAVARCYELFQVMDELDVKRNVYTFSALQNVVARSRIPNAAEQTMNILQQMLKLYENGDVFAKPNTLNYNAVLNACSRTPSKASAQLADDLLHSMELPLIQGGYDVEPDRLSYAMCILACARCPDEAFGVPKAEANLRRMESRAIMEAAKRQQISSAAPPTVTLDIECFNVVLTALSRRKNIPPTRTLEIVKRMEEYAEQGQEHLRPNVRSWNAVLNAYARAIAVSPHSTASNSYAQMAAEFLQHMRLDLGIRPDAFSFAALLSAFQKWDHPEAVAQADALVREMESLFEQNEIDAPPDVYHYTILCGAWARSGQKIAPQRCLQILAHMVERHRLGYPNVKPNVRTYNAVLDCLARAGAEDRAEQLLFHMLKLYRDGDHDAEPDAFTFNCIIHAFSKSRRKGAGRRAESILDRFLEYHEEENQSIRPDTRSFTHIIAHYGRSRELDAPYRAEYVLNRMVSLCKDGNKDLAPNLFAIKTVVDSYSHAKHPDAGRNAERFLNLIRELREKHGITRLERDTSFMNSVLFAWSSCGSEDSGHRAEGHLLEMEDSFDQGTISFRPDSRSYEMVLSAWAKSESSDKAKRALLTLRRMQEQQRTGNPFVRIDEAAYSFVINACAFSNAGEDLEAEAFTIAVKLLDEMLESKSVHPSSLTYGWFIQACGRLRVAHALKSVQIGRAFHLCCENGLVNDFVLHRLKGAAPDPVFKELLAPVLSNLPPRFPKGRLAVNNLPSDWTCNVHGNRKIRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT94</accession>
    <name>B7FT94_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177802.1">
        <property type="nucleotide sequence ID" value="XM_002177766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT94"/>
    <dbReference type="PaxDb" id="2850-Phatr43729"/>
    <dbReference type="GeneID" id="7197256"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43729"/>
    <dbReference type="eggNOG" id="ENOG502S9K2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932101_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT94"/>
    <dbReference type="OMA" id="FLINGWH"/>
    <dbReference type="OrthoDB" id="197846at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855305" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33732" checksum="90172E6619B1BA3D" modified="2009-02-10" version="1">MRGSLVCLLIHLAAAVSWGLPWSGDATSCVRFEEATVDADGPNTENDLASAEAKIADFLEATPTNGKFHVQGWRWHTMSLVREADRLNKLATKLLEKSSSDEAHSLEKEVDYVVGFNMKGLHKIERDLFFPWVRKKMELSIKNPDFAKAFSTVMDQLEGDRQTMETLGMSLAEITRMAADSDNPSNVRMDAYDAVASMSATLAKYGRAMLEREDKFLVPAVANIVPESEQKSFNNKVIRNLGVFDSRVHLVGMHEAVWQLDKESERKLFDETIPSIPRKMIPRWKRLLYEPAIGKLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTM2</accession>
    <name>B7FTM2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178440.1">
        <property type="nucleotide sequence ID" value="XM_002178404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTM2"/>
    <dbReference type="PaxDb" id="2850-Phatr44300"/>
    <dbReference type="GeneID" id="7197962"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44300"/>
    <dbReference type="HOGENOM" id="CLU_044543_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTM2"/>
    <dbReference type="OrthoDB" id="40253at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68432" checksum="7297775B743CBF3E" modified="2009-02-10" version="1">MPLSLNITIAVGDNSFSTRSVSHNGPDPRWGKGRSEGFSSRIRLVGDSHHSVFASTHFSLNKHTSYPPRTAPHLIANLLIFYRGTLRCCLFTVNSFEFGAASVRTGRLGTFPLGHWHVTIMKVKSRKYRQGKTPATLLALAASMIAISGRVILTSTRMPTMDYDGSGETRVLLRKEPTQGPMAPSQRRNLSTLAVAAPAENHSTKTTETSLCNTQSRISSAVDPGDESFSDPMAQQATDSTFSACILFMDDNPRLVEWMAYHYYALNLREVVVAVDRRSKTSPWDSLRRWTPYMNITVWNDADYGYVVDDDIAIKGSVAQKTDAHRDRQRFFYRQCTNHLKRRHRTWTAFYDVDEYMTIDERLVTNAEERMAKPGSVLQMIQEVQKRDPVPFGWRRNCVLIPRRHFSAAPSHPEEVSKLVPSVVNADQLETLRWRYRTEGGTDGYPKSIVDVSKITVKETTKFDIHRVVSDACPKPRAGHTFLTIHHYLGDWNLYSYRDDARKGARRSRHVWELRAFRTEGGTTDQIRPWISGFVAAMGEDRASLLLKDAGVLAILNVTNDEDSKWDVEIGQLMDDLPKKDRDFLQRLHTRFNVSKSVVSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTS0</accession>
    <name>B7FTS0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178466.1">
        <property type="nucleotide sequence ID" value="XM_002178430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTS0"/>
    <dbReference type="PaxDb" id="2850-Phatr44341"/>
    <dbReference type="GeneID" id="7198031"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44341"/>
    <dbReference type="eggNOG" id="ENOG502SMPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753292_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTS0"/>
    <dbReference type="OMA" id="AHERWRQ"/>
    <dbReference type="OrthoDB" id="37577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277:SF3">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277">
        <property type="entry name" value="OS03G0850700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="213"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41073" checksum="8FA8B79F5036E44F" modified="2009-02-10" version="1">MSESQFGSTSVDVAKVLHISFAADPNGSLGCTLVHCDKAADNEMFVPGYATIGRLLDGDTVARKFDVQVGDCIVAVNGEGFRRFAPDYDTDKVEVLNREGEEVEVELDHKVISPGDAYDCLLLKIKTVKSAAPDPPLILTLERYSWDARPNSWGRFLDARDGNVPAAMQLMQDHEAWKAARFPIDLKTSGLQKILREKAVSEIDVEFLHDFPPTVYVEYGKLLNMQTAGEITADDVVAAFVIFTERMLAKAKNPRHPQTCQFIDLSGIGITSGLRAETLKKVYKVFEPNYPETLFKMVMFPVSTMFATTARTLLSFVNEKTQKKFVITNSLDKVCAELGWNRQEVEDCGGVTEFMRKHEKVGDSLHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTZ8</accession>
    <name>B7FTZ8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_3687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178514.1">
        <property type="nucleotide sequence ID" value="XM_002178478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTZ8"/>
    <dbReference type="FunCoup" id="B7FTZ8">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTZ8"/>
    <dbReference type="PaxDb" id="2850-Phatr3687"/>
    <dbReference type="GeneID" id="7197868"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3687"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="InParanoid" id="B7FTZ8"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="9">
        <location>
            <begin position="57"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="239" mass="27070" checksum="5FA27AD2E94FA43C" modified="2009-02-10" version="1" fragment="single">IRTGDLVVIMESFDNLAFVYAKEGEIFSNRNGNFHHNDFIGKPFGCKIRSRSHRGYGFVYLLKPTPELWARSLNHRTQIVHELDQSQVIFQLHLKPNMTVVESGTGSGAMSHAILRTIAPHGKLHTYEFNEHRADTARHEFANNGVGHLVSVHHKDVCGIRGDGGFDLPPQSVDGVFLDLPEPWLAVPHAAFVMKPNARLASYSPCVEQTQRMVETLRQSGFHSIKTMEYRLQEHYVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUI7</accession>
    <name>B7FUI7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_34027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178328.1">
        <property type="nucleotide sequence ID" value="XM_002178292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUI7"/>
    <dbReference type="STRING" id="556484.B7FUI7"/>
    <dbReference type="PaxDb" id="2850-Phatr34027"/>
    <dbReference type="GeneID" id="7197805"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34027"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805271_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUI7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29736" checksum="FFECDF3F57AA59A9" modified="2009-02-10" version="1">MTYESYLIKTWEQDPSQQQGLSFIDFLVSKSGSDPGKASRPVGLVDVVKLRRDGTDTRMAAIPNAVIQKHKVPFFSFIKGVLGGDLQTLAGCPFFLLLNKYLQVYGPVFNLSFGPKSFLVVSDPVMARHVLLETSPEKYCKGMLAEILDPIMGKGLIPANPAIWKVRHRAIVPSFHKQWLNRMIAIFAKAPKFSPMIYNANQPRGSVTLDIIGKAAFNYDFGSVTDELPIVKAVYRVLKEAKRNQTTPRFSAMLEYTVQTCFVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV07</accession>
    <name>B7FV07_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178840.1">
        <property type="nucleotide sequence ID" value="XM_002178804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV07"/>
    <dbReference type="STRING" id="556484.B7FV07"/>
    <dbReference type="PaxDb" id="2850-Phatr11192"/>
    <dbReference type="GeneID" id="7199849"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11192"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B7FV07"/>
    <dbReference type="OrthoDB" id="36070at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="172" mass="18429" checksum="F4CC374A4FDCC387" modified="2009-02-10" version="1" fragment="single">ILVNNAGVNVRQTADDLTSEHWQQSFELMLTAPFMLTRALSKNMKARQHGRVITIASLQSFRAFPDSLPYATAKTGVLGLSRALSEAYAPPHGYHNVTCNAIAPGYVKTKLTASVFADIERSRRLADATLLGRNSVPSDLVGATVFLASPSASYITGQTLSVDGGFTALGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV12</accession>
    <name>B7FV12_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Dph1</name>
        <name evidence="13" type="ORF">PHATRDRAFT_54330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179062.1">
        <property type="nucleotide sequence ID" value="XM_002179026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV12"/>
    <dbReference type="STRING" id="556484.B7FV12"/>
    <dbReference type="PaxDb" id="2850-Phatr54330"/>
    <dbReference type="GeneID" id="7199631"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54330"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298003_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV12"/>
    <dbReference type="OMA" id="YDRGMVY"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="10">
        <location>
            <begin position="217"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="585"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="882"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112848" checksum="29BC0433EA66F38F" modified="2009-02-10" version="1">MSGANYREADFPGVRAAGRHNNSITTKELTECDREPVHLIANVQGGTGHLLFIHYPSGKILAHDRDIEHIPWIRCHENRTVTAGRTGARTTSSFHGEQQSGESPHEAIGISGGFLLNWVPHDFYEKILDLVLGIIHSDTHRNFYFYSYDGSAYAISISATEMDYSVIGIEIETVGLDDTASHFSSSLLHLGRIVEFYQHEAIAKTACDTVFHLLGKYDRGMVYRFHDDLSGEVVHEIKANHVESSYLGMRFPSSDIPLPSRQLYIKNGVRYIYDVDTEDLPILSLDNEKMDLSQIRMRAVAKPHIVYLRNMGVVSSLSLAIVVDNDLWGLLAFHGYGARYKPSLHQRIACETISAMVSVRIESLMKKAQSARIIKLGQCTMSLKHDQSLIHNLYEWGEGILEIVDGDVLVAHVQDPRDGEGDRIVLGDPLLVPKDSFWTKMSSYQNRELCVISTRKALTDIKLTQEECPASGIVFFQEGRTQIMIGRAMRSKDVVWAGNPDEPKLRIGGILNPRNSFTQFIEKARKESRAWTVQDISVISVLRDRICEHSYAYMMGLLRGDIQDANRKYLAAIDRARDNYEFFAHMSHELRTPFHGVMGCLSILHESIEDMPAAEVRDVVDTAIASGNHMINLLNDILDISKNKHLSHISAQDKVIYQTLAFETIDCMKSLATSRKIEMRSSIEPKGLEKVVIVTDRTKIIQIVSNVVNNAIKFTGEGTVDVVFRLVDSLQEATMMWERGAEVHAGSVFSMKESEMHTSAEEVRRSTMTFNETHDQKWMTMSVSDTGCGMEPCELVEMFSPYTQSSHGSNRIFQGTGLGLFICVSLCYQLNGFISCASTPDKGTLFHMGIPVGLLAEDTVEGNQTLTDDTKETESVIQMSGPILIVDDNVVNVKILNRALLLDIRRAGLAIEVLTAGGGAEGVQVFRDKRPSLCIIDYHMPDVDGIEATCTIRKYEQENKIDPTYILMYTADATEQARALILSSGVNDIMSKPPPKGFIAGLVQRLRVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV36</accession>
    <name>B7FV36_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178855.1">
        <property type="nucleotide sequence ID" value="XM_002178819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV36"/>
    <dbReference type="PaxDb" id="2850-Phatr44967"/>
    <dbReference type="GeneID" id="7199495"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44967"/>
    <dbReference type="HOGENOM" id="CLU_532645_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV36"/>
    <dbReference type="OrthoDB" id="56427at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="512" mass="56191" checksum="E8D71BD5B68092B6" modified="2009-02-10" version="1">MKVETEEHHVEQEKGEETPAFSTSKKVRFDAEVKPGLSSSTSSNSKPITPQRQVDSRRIKFGSGKGHPCRDLLTLLSIVGILLVVTMDFSSDTPEFDPEERTPKEKAASRLNKVKESLERSLQDHIEATRRMASCDIFISSSSIPGTGNGLFAGRAYQEGETVLLDTKAFGHPILGLPSNAALSQYAFLVKHHPTLVNLEGSLFHVDFDHFKAGGQTFQFKATQQIKAGEELFVSFENHPQSSSLFPSKETLPFLPYIPTYNDYNTIDSILDDVKSTARRMSISHSRHRRNMLIDSSHILKLARGIVGRLHESLAALIPSTGDAWGKRPDNTPSVWTALENRTLVSLQLSGFCLTDMNQEKDGTLFVTRNVSKGEIVTVAPLHVATHAALKAATEKSAAEEAWCQTSASDRCFGKAGSSLVLCPITNAAFISISVDVENVEFQWSMNQVPSQSADQAISSPAGTLSWNILALRDLHAGEKLVVKGSKPSGFDFRVLEKTDLFPWYTAETANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV60</accession>
    <name>B7FV60_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_11286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179083.1">
        <property type="nucleotide sequence ID" value="XM_002179047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV60"/>
    <dbReference type="FunCoup" id="B7FV60">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FV60"/>
    <dbReference type="PaxDb" id="2850-Phatr11286"/>
    <dbReference type="GeneID" id="7199658"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11286"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250268_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV60"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="75" mass="8817" checksum="476DFD1009617F33" modified="2009-02-10" version="1" fragment="single">KDPNAPKKAMTSFFYFLNEMRPKIKQENPDMSFGELGKKAGELFRALSTNQKEKYEKMAKSDKLRFKEEMSKYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVM3</accession>
    <name>B7FVM3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DLDH</name>
        <name evidence="14" type="ORF">PHATRDRAFT_26432</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178956.1">
        <property type="nucleotide sequence ID" value="XM_002178920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVM3"/>
    <dbReference type="FunCoup" id="B7FVM3">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FVM3"/>
    <dbReference type="PaxDb" id="2850-Phatr26432"/>
    <dbReference type="GeneID" id="7199894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26432"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="B7FVM3"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
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    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
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    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
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    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
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    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
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    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
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    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF223">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
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    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mercury_reductase_MerA"/>
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        <property type="entry name" value="FADPNR"/>
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    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
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    </dbReference>
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    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="35"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="381"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
            <begin position="175"/>
            <end position="177"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02852"/>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EEC49654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="52828" checksum="9E7EC8AFFA3D73AA" modified="2009-02-10" version="1">MMFAAAAAVRVQGRRTATAYAFRSFTSTTPLAEQYDLVVIGGGPGGYVAAIKAGQLGLKTACVEMRGRLGGTCLNVGCIPSKALLQSSHHYHDAKTHFADHGIVIDNVSMDIAKMQTAKAASVEALTGGIEYLFKKNNVEYFKGKGSISGPNGVNVELLDGGTESIDTKNIVIATGSEVSPLPPVPVHNAGGKIVDSTGALDIDKIPETMAVVGGGVIGLEMGSVWSRLGTKVTVIEFMDRLCPAMDIELTKKFQTTLKKQGFKFNLKTKVVKSEVGENGVTLTTEKSKGGGEKTETFDIVLVATGRRPFTEGLGLEALGIEQDKLGRVVVDAHFRTAVPSIYAIGDCINGPMLAHKAEEEGIAVTETIAGFAGHVNYDAIPGVIYTYPEVASVGKTEEELIEAGIKYNKGTFPFSANSRARANGSTEGLVKVLADAETDKILGAHIIGPNAGEMIAEAVIAIEYGASSEDLARTCHAHPTLSEAFKEACMDTYDKPIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWE9</accession>
    <name>B7FWE9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45086</name>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002179338.1"/>
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    <dbReference type="InParanoid" id="B7FWE9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="522" mass="58109" checksum="AA45D03D7AFD0BBB" modified="2009-02-10" version="1">MKTPKRHKFSTMFSYRSSFSKSTDPPVTKTKDLLQPATSQGTMVSVEDSDTRIADHKLSYDNEEQDLFEILPRETTVVHDDEYDDNSVPSLAPRDLTDSILDDVPTLRSSVGLTSPPRFDHSPVVVEPLPDKVAIIEEEKEDPMPPPLEQQEPLEDQNLLVTSTSDLEPLLVQLDDAQKVSINERVHQRTLTEDDVLLDPCPRASALQLVGRTFFAFIFVVSLALPLSRIGSGATLSLPNLPTYYDTHPMPAKHPAEQSTPTPSPIQYSTDMQSTINNNQPVAKGGGIHSVKPPLSSLVSVAYGATSFPEDKIFAATLDLARQATGKGWWLAFSPFSSLAWEEKQTLGWWTTMRLSMQVLLVLGLITMALAGRGRRFAPPTLLSVSQLVKVKKVPTLHKEENDFSDYRVLYQFQLDFEKVKTDVGRRSKNLTLLLDEFGIDGDAYATLTIEEIRSILPYLPGHAIVSASKTVLVEGLLNRYSFTLSRFTKNQLVGLLHLKHQDVPSRFTKAELVHMALQAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWU7</accession>
    <name>B7FWU7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179442.1">
        <property type="nucleotide sequence ID" value="XM_002179406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWU7"/>
    <dbReference type="PaxDb" id="2850-Phatr45210"/>
    <dbReference type="GeneID" id="7200094"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45210"/>
    <dbReference type="HOGENOM" id="CLU_394570_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWU7"/>
    <dbReference type="OrthoDB" id="48978at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="699" mass="77058" checksum="CEE840DE95028943" modified="2009-02-10" version="1">MRYSRQKSSDRETYDSSRMRLSTDPVSGSEECRMSISIMSPGKTPSSFSNQSIRPNITPSPIRHQVSSSAFSTPSRSSVGPLQQSTMQASSPLSPNRFPLSMPLSADGLSLRQRLTKAKTKQARQLFRLQNTCQTNLHPNIVLHRGPPRDGAPQVSNERKLVSELHAVNDLSRPTSNQTGATTVSSAIRSLGVLSSLYRLDELESPGQVDTFTDSEAQVDNENLDAKAVAGSAVFTQSQLDNVHSGDKAKAAPNSLHSEFNEDLPLLPEVSQSTDTFTKPIPPQMLYHHAPTSDIPAKKLTPLQGHPTSLARLASTDRNGGTPECTWIASMPVQLPNERRKGPWTKGEKLANAEKLKRWKAKRTMAEGKNWKGTGLCSSSGELLDNKTYATSREASTQCNAIFSVFETAFQGRCAPVQCELSRIIAASKQFDEERTQRVDTTNLEFSEEDDSAEIRGLASRNGNFAADSTLPSAVRPQSRLLLNLEMKSGPILTDASVSIPCGQSKVSDVNILEIHDENYISTFILKIVNFGTPLLLHKQQRKEKCSKALSIVAFLRKGQQECDWSFSGPSLEWVAEDDVPLKTVNVFAIKKIERASSLHLENYPFAMPQRSMILTLKDGSIHVFEAQSESGADCFVFGIRWVIARLSFNLIIGNQEVSCELIDIGMKEGKKSLDAWLLDETKWTRAMNGVSNNMVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWW8</accession>
    <name>B7FWW8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179452.1">
        <property type="nucleotide sequence ID" value="XM_002179416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWW8"/>
    <dbReference type="STRING" id="556484.B7FWW8"/>
    <dbReference type="PaxDb" id="2850-Phatr45225"/>
    <dbReference type="GeneID" id="7200105"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45225"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FWW8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126180" checksum="EF31D9D8FAAD1740" modified="2009-02-10" version="1">MSFTATADATFIYGMDGSGKLFLPRPLNSRSWEDGENGLKRSRDNSTEDVDDSTLFHTFLGTSPDDGDNHAYSSPLRSPTTVSSDQDDRAGPERDARTPPRALSNNSLFGEDFVNSSRRSGLNGRGAFDTEDTDHILTLSPEQQPRLPFYDLSPSETMTPPSASHSQTLSPPPLIQHLENVSYSSRTTSQINHSNNNNNSHRPPRAPGQIARFSSHSVEGTVTSAFAAHLSKPPVVLPRHHRRASSAGDASFLSALTDASFEAPNGNDLLLPRGDFTKQQHQEDRRLGHRRNASWDPTVESQLHGEVRGMNIDVPVALQQPILSDFSLQMDQARIPDKSAAMNPVVKKSLMTLVKRSPTVSLAPLDHSNASIAALDNLTAQSSTPSETSSLPATRKALDYEEDHFRAKEIDAKVEKLIFDTHEGHIQRLTMFDSNQAKNPKVLREDALLRASSAFEAFQKIISPDDEADCFEVETGHELRLNESSMDMLVRHARIMKSILVLAYPTGGASAAIASGKTSRLQRGKEEESNDTDQDTQDQQESDQGNSSVAQDETGHKINHLSIKDSVGLSNEFVRNAKAVEDQWAMFESLCNGEKDFLKRTTLNLVFYAILPSTMIACFLFYGAGNPQAGWWQPGEPAVDPKGDLNGTTVTSASWWCLFLGVRQIVLYALASCFEVCLVKYLALASPGFIRSLGPNLALSISQGHGYPIKLVSFATLSCLLSYGKSDFKNHWLFWQTKIEVLSQANPAGNVSSHAFYGRVLYAFIFVGVSTWLKRLWAGQHFGRRLYSRYNHQLTKILNKMLLISEVAYLSSNAESFARSDISVNPLKADPSFVNRSSSDERTGGRIKVDRNVDKYSQNLQLPTLFENLKEYVAQSNDENINVTSLKDILLFHHSYQMIQSEYPFSAVFGPSATQAQCSNSAEIVYRRLLKLQDREEAAGLEFGVLSRIVLREKGDIASNKIRWPFDIGDHITVSNDDRMDVHGAEGWIVEKMDLFTTTLRMISSRKVATFSNASLARSCIVNLKRSENAQINILLKFDSEISLSKVKVFTKAVNRFVEKHSKEWLAVTSFRKIRVEADLGFVEYQLGLLHRKAWQDTLAIAESRASVSGFCGALQKKLGIALATTSVPKVYACCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWZ9</accession>
    <name>B7FWZ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179468.1">
        <property type="nucleotide sequence ID" value="XM_002179432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWZ9"/>
    <dbReference type="STRING" id="556484.B7FWZ9"/>
    <dbReference type="PaxDb" id="2850-Phatr45250"/>
    <dbReference type="GeneID" id="7200120"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45250"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340537_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWZ9"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855448" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="191"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="743" mass="82974" checksum="F3663A5B9967FFFB" modified="2009-02-10" version="1">MKRLRGKRITLLLASVIPLLAVDDVPMWQSTRDSDEEHPADQEKELSCREQTQIDRGTKQFREPLHRPNGDRDSALLRQSLNPDILFEGSEFGQHYNIVVPFRMGYPHKLVGSYVENRYRPPENDTSLTSISTRLRMDVVRDKFVSKDEKSAAEIGVVERSRETIKNEKVSAYIDDSRAGEDLPGPETMHASSGDSKGDKFSEEDGLKRVLVDYASKSAGALILEKSSSWNGISNVLNGDKDKYAIIPCEEPQKSVVIGLSEDILVKQIVLSYYERYSSHIGTFQVMGSPQTMGNWVDLGTYTSPRGNGKHAFDLHEPSWARYLKFRFVSHYGDEHYCTVSQISVHGSTMLQGFHEQWAETVEEQPNDKNERDVDVSGSKIDPTFSATDQENGNDGSVQGTVSTIGQCYTRLDAVCQMDYSFERSAFLFASGRSSTPDFDLLSALSSASFCQLGRQSARTNYSHFVELGRRALTISPKRGRSTKSKFVADLSDQALFHSLTESVVVKHIQSLISRTTGIDIHVERFGVLATVDRTPDRISVDDSNPPATVSSASGVIAGTKLVTSEVEAIERITDEIESQPLLQAIQQMEEKIPFDTAFHASGFSWSKILEQLPSAACLEKLDFADFRSGKKLNLRNGGPGSHGNAQGGGGMEPIFKKFTDEIKALQTSVSIHDQFSKALASCYQQVFLELLVEMDVKRIGEENAEWFIFFLCSISMDVSNYWWCCNDFKATDIAFFPKPHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX78</accession>
    <name>B7FX78_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179507.1">
        <property type="nucleotide sequence ID" value="XM_002179471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX78"/>
    <dbReference type="PaxDb" id="2850-Phatr34974"/>
    <dbReference type="GeneID" id="7199953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34974"/>
    <dbReference type="eggNOG" id="ENOG502S3FA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851166_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX78"/>
    <dbReference type="OMA" id="YHKFFTR"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="36492" checksum="42A4CCB93FE3CF8D" modified="2009-02-10" version="1">MTAAARYAALLQWLRSNDADISPKIDLQPSSRGGGYGAFLTEDAVEGELLFTIPRKTCITLADSIEDDACGEGFKALIETAGPGGNTVVMAGFMARERIRSLESQKPGSIVDDSSFGPYLATLPWERGMNNQEHVLYWDNKDIEKYLKGSMCYGEALDLRKEVDVAIRVLNTIVGKSIREFRGDYLDSGFQWPWEKAAQASEEKLKGPPEGLAEAVKGAFVCMLTRAFEDGDGDEEKLVPMLDMLQHSDEPNISHAMRKSDGAVEVRARQDLTAGQELLNQYRSELEETMPYHRFFTRFGFVPGIQEEMTNLFEDKSSIFFAQKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXB9</accession>
    <name>B7FXB9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_8270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179528.1">
        <property type="nucleotide sequence ID" value="XM_002179492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXB9"/>
    <dbReference type="STRING" id="556484.B7FXB9"/>
    <dbReference type="PaxDb" id="2850-Phatr8270"/>
    <dbReference type="GeneID" id="7199973"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8270"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734601_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXB9"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="84" mass="9465" checksum="8650B9D629F8EDD9" modified="2009-02-10" version="1" fragment="single">MYIGNLSFYTVPETLQELFEEFGTVIDCYMPEDPETGSARGFGFVTMDKEAAQRAIEEIDGCELDGRIIRVNEAQPKGSRPARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXE8</accession>
    <name>NNRD_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">PHATRDRAFT_19831</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="1"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179544.1">
        <property type="nucleotide sequence ID" value="XM_002179508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXE8"/>
    <dbReference type="SMR" id="B7FXE8"/>
    <dbReference type="FunCoup" id="B7FXE8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXE8"/>
    <dbReference type="PaxDb" id="2850-Phatr19831"/>
    <dbReference type="GeneID" id="7199989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19831"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FXE8"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416177" description="ATP-dependent (S)-NAD(P)H-hydrate dehydratase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33682" checksum="896A7DC729C20344" modified="2009-02-10" version="1">MKTWNDGKTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEMTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXJ3</accession>
    <name>B7FXJ3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179778.1">
        <property type="nucleotide sequence ID" value="XM_002179742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXJ3"/>
    <dbReference type="PaxDb" id="2850-Phatr35092"/>
    <dbReference type="GeneID" id="7200493"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35092"/>
    <dbReference type="InParanoid" id="B7FXJ3"/>
    <dbReference type="OrthoDB" id="55279at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="34440" checksum="15935BA98F76C80B" modified="2009-02-10" version="1">MAADGANAFRGALGRIGWSVPAANVFTNKGFDAMDSLGLVTCDRLKDICKIIRRGTDGVASVPAAGGNAAVAAAPGTPGIAIPMMWEYKLSGMHLWVSERLRQGTPVVAADFTAAIGNLYTRKLLVNYLSSVTGVNKVPLDYVVRKDDNVAAPDTEFETEHEKLVLLTPHTGTAFDKGNGKVWIQVKQLTVNGPAWTYVAPFEKKRDGRGAVKALNSHYEADAVMSKSKAAAFDVLEHTTYTGERRNFGMEKYTNALSMAFQTLDTYGETLTECPGRRMSSCAITIAQILRCSRDVTVSYLMTCLVDIQCTRMEIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM8</accession>
    <name>B7FXM8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179796.1">
        <property type="nucleotide sequence ID" value="XM_002179760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM8"/>
    <dbReference type="PaxDb" id="2850-Phatr45424"/>
    <dbReference type="GeneID" id="7200511"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45424"/>
    <dbReference type="eggNOG" id="ENOG502SR6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FXM8"/>
    <dbReference type="OrthoDB" id="194949at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="229" mass="26353" checksum="C0F4222E30F8BE36" modified="2009-02-10" version="1">MDRFLYYFTKPVTGVIHRRNFEVTRQPKLKLGIISSKSLVERHTSSSYNTAPEVRGPSKPSQTWERSAKLVKNIDVKSEHMDAIRETHDPSMHLKTIEDELMQTMGAALGKQGEKILYAVQEMNTCYTAYIEALQKCAKNGSNPEVLSIANRFNQRRKEAVKARWELIVHRQAIGMIVNNHEFVMNHYPIPEAIPVTEPGKNLQSKPPPAAQKKFGDQLDWWQRVGRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXP4</accession>
    <name>B7FXP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179591.1">
        <property type="nucleotide sequence ID" value="XM_002179555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXP4"/>
    <dbReference type="STRING" id="556484.B7FXP4"/>
    <dbReference type="PaxDb" id="2850-Phatr45439"/>
    <dbReference type="GeneID" id="7200680"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45439"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614645_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXP4"/>
    <dbReference type="OMA" id="DQCMFRI"/>
    <dbReference type="OrthoDB" id="410751at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40280">
        <property type="entry name" value="BLR6907 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40280:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49997" checksum="5931A20983E9E019" modified="2009-02-10" version="1">MMPKKTSLLSRFTFALVEISLYSFLLESTLLPVASFTTTTTLLYTSGKTDIVGFPVASTLSFSYRRSQTCRASAESAGNQQQTGEVPLENFRQMVSSSIVAPTSMPVDRSTLTLLEHVNLNVPSQEYVLPFYFDLLGCGMDPRKAENLAPDAPKKTLWANCGASQFHLPYGATPQRIPGHIGLRYDSLDGLRSRLVEQTALRDANKKNEDEDTKDPIVRDVAMGVDFRTGHEYIKLVDHYDNVFYCRAGGSVVDFRWQQPFIRASETNAWDNVATRFGMDETDCRGLDYIEFKCPRGTAEKIALFYDSVLDATTSVITDDEGHNPTQVAIIAFGHIQANGKADQSLIFRETDETLPPYDGHHVAMYIGENAADFDQAFKNAKLANVVWVNPRFSDKADTLEGARHWKQFRFKNIVDMETGETIFELEHEMRSIEHEAWPGPPLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXQ9</accession>
    <name>B7FXQ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179599.1">
        <property type="nucleotide sequence ID" value="XM_002179563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXQ9"/>
    <dbReference type="STRING" id="556484.B7FXQ9"/>
    <dbReference type="PaxDb" id="2850-Phatr12104"/>
    <dbReference type="GeneID" id="7200687"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45450"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781832_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXQ9"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010190">
        <property type="term" value="P:cytochrome b6f complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044241">
        <property type="entry name" value="TxlA/HCF164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN HCF164, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353:SF1">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN HCF164, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="207"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="355" mass="38584" checksum="D6271DE6A512BE9E" modified="2009-02-10" version="1">MTLTDGRFQFRAWRFFQPSNAGLLLTILHFITLISHSTDSFAATAHPTECRRLSCAAILRLQSTSGNPRPTSSSSSADTAPGDQHQSSVQNDDSNEALFITNGSVKLNDPSKTPPSSQFGDSVQFGQVVRPKYLDKDADPPVGLTMNADSTNRDDSTTASKATPSDEDLAASLRRRNLNVAVGSIALALANFAWQFFHPIEPVQLLMSMQAESPPLSVIGKNGKPTVVDFWAPWCENCKLIAPTLLQIEQEYGDKVNFVMVNADKREAWSFIDAFGVDAIPHLALVSANGDVETALIGPIPKRVLRADLDVLLENAARASPADGNSRTSAPPTKLPYTMLDVFADAPEKRRVQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXV6</accession>
    <name>B7FXV6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myo-inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_51869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179625.1">
        <property type="nucleotide sequence ID" value="XM_002179589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXV6"/>
    <dbReference type="STRING" id="556484.B7FXV6"/>
    <dbReference type="PaxDb" id="2850-Phatr51869"/>
    <dbReference type="GeneID" id="7200581"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51869"/>
    <dbReference type="eggNOG" id="ENOG502S0QP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_2_1"/>
    <dbReference type="InParanoid" id="B7FXV6"/>
    <dbReference type="OMA" id="FRDHPCP"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="301" mass="32950" checksum="2CF3C6CB04074DB7" modified="2009-02-10" version="1">MLSIRSFHCLQVNFYDSLEAATAENDLDGLVISTPTFTHESVIRHAGVHQTSVFTEKPVDETADKIEALFEYAHGAGIDLCCGFQRRFDPSYVAATAAVQEGQVGTPIMASLFFADHPSPPKDFLLNGGNIFMDLAAHDVDYITHTLQDEVVSVYASGTSSDKDLTAADVQDNATMMMNFQQGAVVTLFMSRSATYGYDQRCEIFGPRGLVSVGNIHANTAVISNANGIRHSRWQYSFPERFAAAFALEMDAWADVLEKGWTWPVTAAQCVRVQRIVDAARLSAAQGSVVTVEAYNESRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYU9</accession>
    <name>B7FYU9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_12311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180042.1">
        <property type="nucleotide sequence ID" value="XM_002180006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYU9"/>
    <dbReference type="STRING" id="556484.B7FYU9"/>
    <dbReference type="PaxDb" id="2850-Phatr12311"/>
    <dbReference type="GeneID" id="7200947"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12311"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263205_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYU9"/>
    <dbReference type="OrthoDB" id="46663at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="128" mass="14760" checksum="54782A99B146A71D" modified="2009-02-10" version="1" fragment="single">SLLPQWEDELRSKTSLSFTVYYGSQGSRTPTREELESVDVVVTTYGTIQGETKRKNPILAKCRWLRVVLDEAHCIRNQQTLASKVCCELSARHRWCVSGTIIQNSLDDVYGVIKFLRHEPWCIPGFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYZ3</accession>
    <name>B7FYZ3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180253.1">
        <property type="nucleotide sequence ID" value="XM_002180217.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr45870"/>
    <dbReference type="GeneID" id="7200968"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45870"/>
    <dbReference type="eggNOG" id="ENOG502QS2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253274_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYZ3"/>
    <dbReference type="OMA" id="WSAIEVF"/>
    <dbReference type="OrthoDB" id="422471at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34730:SF1">
        <property type="entry name" value="PARAQUAT-INDUCIBLE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34730">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855620" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1468" mass="161538" checksum="A51FD87D8BC64406" modified="2009-02-10" version="1">MRKVPLWMLMWAILAGFGVSLAPWRGSIDVSPLPERSLFTITEPSLPKECRNHTSKSRYDPLACWLLHLKVSIPDQSFSKAFLTIEIRDLSCTNFVVEDIDSSYDPSNRNASTSDQNTGTDPLLDLSVANISALCHGSYKSSGVGGNMQAQLQADAGSTNPALAWSLLVQSDHNNSAALKQPVGVVSSHFAATLAVTDLHFTGSASAKIINLFSTTIKHYVSDALGAQLGPLIKSSVDPLLTQYLRIADDFLRPYLGQARERTAERQETESLKEDRELPDQRRLSMQQFGTVATASLVDFTTELPVLTGSLKILNEFTREYLQQGFLQHWLPRKVVNYAVSPFEIRTTAPDEHCGFLFDGVNGIIQSILHNTNGTIHLPVPPRLERISFVLAHYGEIELQLHDWSLSGLDQWEVLRVLDPRDAHEFVTRFVSVGKISLRSDVKLIVTGIPGGVFQGDPLEESFAIHLNSTALDILAVLSAQVDRFGFQNVTVGMFLDALQGLFDGDHSRLPCLVAPIQSLFLSEFAARLNLNGIRIIPQMQSTRHLKTEAASLEQDLDVLLNHGLDLFLTEYQPFLTQALYGLSYGPVETHVNEFLKTIVTHAQDGICPLPPSDESYPQLVNFTRIPWLERFQAFSRLPSTLERINDFLVCTSNYLTGAILEQLSSSLDSGMPRKDVGSSVIIKELAVLDVGSVRDFRVLSSERDGMHLYNKVDYGTGNATSALPPRLAVSVEATYAPANVSAALNITIQLDDMHLMGGSILHYDINRLKGMPMAQVLRRGQCGLAPMNEFNLYGYSGQLGAFGALLNATVNSNGSNTIFIIGSDKYPSVNETASAILAWVVRSTRDILSLSSVSMLARADDLCKDYSIPERKRNDDANGPQDDMPSAASILLVVAACFLLAQPALLLLHRTPDAMPDSRLTGVSLTEPLLPSRLTDSDCIEDMTTVDRVNDSMMHSPYIPGLVRVVVPIGIIGTIVLLLASNLSIGANVDLVISLGDKTIQLPSLFTFGLLNTARDMLKARIYPLFLLVVVFSGIWPYVKLVLMFVAWVVPKASLSPDFRGRMLMALDSLGKFSLVDTYVLVLMLVAFRYHLDVTNEVEVDVYVSPGFGFYGFLLATSLSLIAGHLLVFFHRRCEIHLVNLKTIMPLEPLCEHLFNVEGGLSRKLSGLCQRLLLGTSFATIILLGVGVARKSFQFEFDGLAGLALGDKKIAEYSLLSLGSSIPMSAQEPLSIGIRCLQLAFYFYAVVTPFVCLTLLTILFVWPLSLQRQLLVLTLAEIANAWSAIEVFALSIVAALLQISTFSSFIIGHRCDLINDILKEYFAETDTDHATCYTVRSTVKWDAAFLVAGVLLNSLVVSLTLRVAHAAVDERQVHESALQMDSPLSGSRPPRHSIVAGWAQSPWTSWMLQRPTNEENSSHVSSVVGPPANALVEPSSPWKQNGFTDEWKEAAERDPAWKEWKEATNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0X3</accession>
    <name>B7G0X3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180749.1">
        <property type="nucleotide sequence ID" value="XM_002180713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0X3"/>
    <dbReference type="PaxDb" id="2850-Phatr36287"/>
    <dbReference type="GeneID" id="7201620"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36287"/>
    <dbReference type="eggNOG" id="ENOG502RYTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791001_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0X3"/>
    <dbReference type="OrthoDB" id="44327at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40535">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40535:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852838" evidence="1">
        <location>
            <begin position="34"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="37985" checksum="41D7F5DC12EE7A4C" modified="2009-02-10" version="1">MKKDTPYKVSLLAYVRSHLLLLLVALVVSVVLGDPSYQEQFSFVSHRLLQTTINNSNGLAGFRTCDGCFCIVENEGEMCPIDPPFTNFTSIIPTLRNLTLSNPIGPDAACNPYTNETCALTPSQNLGGGACVVEMQEPLTDFSSCPESWSYHLRTFSGTFEEATQQRLFVTHNGSCGACSSLQDLAVYMEQGANLREASSRCGALGLIDADRAIQCFEEIGFSTEWATIWYFNTEKTAEACILLCAPFVLSGNSPNGDPPTCPLAPCIDCDETQAGPIFRAFAGRTRRNSGLLSDIIRPCDQVVRVEQVDPCARATLAPSMAPATTPPSSSIRWGFPVRGAICTAVLLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Y9</accession>
    <name>B7G0Y9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_46361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180758.1">
        <property type="nucleotide sequence ID" value="XM_002180722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Y9"/>
    <dbReference type="PaxDb" id="2850-Phatr46361"/>
    <dbReference type="GeneID" id="7201629"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46361"/>
    <dbReference type="eggNOG" id="ENOG502SDHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459657_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Y9"/>
    <dbReference type="OMA" id="INWNIST"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="85"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="594" mass="63939" checksum="FF2D5D57A8194CEB" modified="2009-02-10" version="1">MSGDCVPPPSTISFPSVPSSSSRSDLAPPSSAHTPQDANAIGSNTPSLLFSPPRQASSQSFSFVTRPRFLYATVFVWISVTGGRFLAPFLRHQAGLDDGQIGTVLALQTLLTTLTGGYGGAWADRREMMYPHRGRAQVLGVGVTMGTISFVLHSGINWNISTSRSGSRINDDGDEGNDHKYERYLHYALQCGFALATSLVFPVLDGMCLAYLQAAALPKQAYGRERLYGAITWAVTNLCLAPLLDCIGFVILYWLSCLSCLAVLVSIVVYVQAQQQVSRQLLKQKSQNIAVEEVTHDEDDEFWGGRDRIRDSPTDIGNTFADADNSHCSQSSSGLHTASTADRRLTTIQLCRSLYGTTFGFAFLVAVLSLASGQAIVDSLSFLYFETLGSSYMTMGFMILLTVAFEIPIFHVAPKLLEYAGAGGLLLLGGACYVTRTIGYSFIPQGKVGWVLWLEPLHGITYACSQTATVDFVAQLLPDAGYEATGQGLVSVTRGVGSMLGLWLGGTAQNIFGARIVYRIASAVVLTGSSIFALTLLGMTHSVTHVSRSHYMLSQLDGDDDLDVGKSDLELTAVQSNDDSSSQSEEKNSVGYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1B1</accession>
    <name>B7G1B1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_27956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180823.1">
        <property type="nucleotide sequence ID" value="XM_002180787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1B1"/>
    <dbReference type="STRING" id="556484.B7G1B1"/>
    <dbReference type="PaxDb" id="2850-Phatr27956"/>
    <dbReference type="GeneID" id="7201808"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27956"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_1"/>
    <dbReference type="InParanoid" id="B7G1B1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Peptide chain release factor 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptide chain release factor 3"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Peptide chain release factor 3, domain III"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-G-like_DII"/>
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        <property type="entry name" value="EFG_III/V"/>
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        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
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    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001964">
        <property type="entry name" value="PRK00741.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556:SF2">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="95"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="634" mass="70603" checksum="F9DB5284D030205E" modified="2009-02-10" version="1">MRTSPSSATTMLLARQRRTAVALLVLCIGSQSATAFSSVAYPSSHRSRGDAFRSSPLSIQGLRQSTTATAISGSSSTEDTPPVSTNYQAPQIEIDRRRNLAIISHPDSGKTTMTEKLLLYGGALQQAGAVRQKAEQRATQSDFMEMEQERGISISSTVMNFEYQDFGIRLMDTPGHQDFSEDTYRALAAADNALMLLDAAKGLEPQTRKLFEVCRMRRLPLFTFCNKMDRPALSPYEIMDQIEDEFGLETHPILWPIGDGDRFKGVLDRTTNVVHLYQKAEKRGGKAGVQEVPLEDTVTLKATIDDEELFHKLLEDAELLEELINPLDMERVMKGEQSPLFFGSAMTNFGVQLFLDKFCSMGTKPMGRMADTKSENEEEMIGPNHEEFTGFIFKTQANLDPKHRDRLAYVRVVSGRYEKGMKVSHSRSKSGKKYNLAQAQALFGSDRSSIEVAYPGDVIGINNPGNFAIGDTLFTGGARVAFPGIPSFSPEKFAYIRSPNPSDYKSFRKGIDQLLDEGAVQALRQRNDDGGGPLMLAAVGQLQFEVVQARLKNEYNVESIMEPLNYSLARWVDGGWEAVEKADADGKLFGIMICQDRWGRPVLLFRNDWKAASVAEEEKYLDLKPWSTPPIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G257</accession>
    <name>B7G257_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002181116.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47012"/>
    <dbReference type="GeneID" id="7202245"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47012"/>
    <dbReference type="eggNOG" id="ENOG502TJTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257646_0_0_1"/>
    <dbReference type="InParanoid" id="B7G257"/>
    <dbReference type="OMA" id="VISWLCA"/>
    <dbReference type="OrthoDB" id="47619at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="300"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1352" mass="145503" checksum="9635E842C81C5CE1" modified="2009-02-10" version="1">MYHDDASPYAAPGATFGTESHGSVSGSSNIGGGLAQRHRSTESATAPSPFVQSPTSYTYPAATTTNSAAYGYYAGGAAPSAYPSPSTQWGTRPSKNTAPTYQHNGAAMAFLIPSLYVMLIQDHVHDGASWSSSTPLTTFAILTVLLYCLDMSNLREGFLYTLWLSVIVVLSVWGWGLLLQLGDEDEHSGLNVLLILLQTGVYGFVLASGATFVSLQCHWIVQTMPVNTNGSTAAVTSKSMYLDKPANPLPSASSAEASAAGIGLEHMLHGVVPVVFAATCTPTIVGYLESMYGRDTAATLMPYIFLFLLVSALLAFGSSTTSFPITPSAADRSGNGSNLDSKAISSKRPDFIIRPQVAFWHTSLVLIVPVTMHVGICYKRLLSRYADSDDWYDWFLAVAIPYLCLYGLSALDNSDVFPNPYSNRALFGAGGVTLRGTLVPLGVSVLASLALQQRYLIPLCHQFSYHFLGHKSSSWLVSLYWTIATLSFVLCVWFWGRKSVVTNQPIFGEYHEDVVQLTLSLGGLALGKAFGLPWNFTPLPILAFLGLSLWLTTRMLRYLTIFLFVVHAAGVVTFTYRFAGIDHSLALPLGMNVSLIRFGMLLVTSSILIGLVAGLGVRSTGGFGAKILKNVDVTGLVLIAYTLTSMALEIALLKRPVPSSELMGVDDKDLEEEDEMLYDHTWAYMTSFVVICITVFMKKVRILSARTSGIVLALAMGKAVSIFIDDGEEEDPADGSSLTAVFIRALCAAVLCIVMFAPRIFLQPIYLKSAIRSRGLFNGRGGSELPTRALQTIVLYAFVFLPIALVIAIPYVLFPLASALAGEYGGDSFYSSTPPVSELIGSTVALWGLACLSTLNFYLPDGGGEMWKKLSALAFLMGVGIFFTAPTFGAGNKDVMMNPYASISSVGSQMVLRSKSRTGGWGLLSAALATFLSIAGPLELKERRNKSGRKDKYLLFRTMSFSLLFGGGVSWFIILQSMSETEWLYLFLTSIACMTIAFLGTVASVLGYHIELENFEDVDQIFQIWILALPALIPVTGAPHFFKSQGSHPFGSGGWLATYMSIASITLLVFALSLRSRLLKNQSTRSVANLSSIFSWLCAVTVIYGRYGVSGMDANYDVITFAGVPFPILGTIIVSPILLALEGESASSESRSRVQRLTTAGPRTQSSMGLKFSSLNESNRFAPLLTAINVVFIAASLYAVLLRGSGLFNMFGASVAKSHEGVFYKVFGDADKDNEDLAVLAQKTISHSKALATSAKLAGSGFWTAGGFFGPMMHLGGIGATAPSFALQIAHWFKYRNVSASISTLVLPLNAVPLILCRGIPALQAVALINIVTGIFQAASIRKADRLSQMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B1</accession>
    <name>B7G2B1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_37164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181348.1">
        <property type="nucleotide sequence ID" value="XM_002181312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B1"/>
    <dbReference type="PaxDb" id="2850-Phatr37164"/>
    <dbReference type="GeneID" id="7202133"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37164"/>
    <dbReference type="eggNOG" id="ENOG502QQ7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057974_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2B1"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33794" checksum="A6259C473574CA04" modified="2009-02-10" version="1">MSAVNGDSSFPTEMSEDERYLFDLNGYVIVRGVLTPEQVEEANAMIDKHESEMIQRSDAALRNAVKGTKLYGSGPGRKDLGQVLEWGADSKLFKSILAHPRLVPLFHGIIGKGYRMDHLPFVIAQDKGAEGFQLHGGTIDCTSGEYNPHLAYTYHHGMIRSSLLGCNVMLTDHNPGDGGFCIVPGSHKSNFKMPKGMVDGEKYDEFIRQPATKAGDVVLFSEGTIHGAMAWTPEERQRRVCLYRFSPATNVYGRSYFGHEGGGWPDAIYDDLTEAQQAVLEPPYANRLDRPNIRDDGTHAKETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B5</accession>
    <name>B7G2B5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_21323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181350.1">
        <property type="nucleotide sequence ID" value="XM_002181314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B5"/>
    <dbReference type="FunCoup" id="B7G2B5">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2B5"/>
    <dbReference type="PaxDb" id="2850-Phatr21323"/>
    <dbReference type="GeneID" id="7202135"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21323"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="InParanoid" id="B7G2B5"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="10251131at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15296" checksum="019D2E2931C2DFEA" modified="2009-02-10" version="1">MSDSAVLVKTRKFKKNPLLARKQFIVDIIHPGRANVPKSELQGVVGGMYKADPKLTVLFGFRTKFGGGKSTGFCLIYDNEESMRKFEPKHRLIRQGLVEKKEQSRKAIKEAKNKAKKIRGTGASIAKHKAKRAAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Z2</accession>
    <name>B7G2Z2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181698.1">
        <property type="nucleotide sequence ID" value="XM_002181662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Z2"/>
    <dbReference type="PaxDb" id="2850-Phatr47328"/>
    <dbReference type="GeneID" id="7202392"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47328"/>
    <dbReference type="eggNOG" id="ENOG502SP4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675227_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Z2"/>
    <dbReference type="OMA" id="CVDGTFW"/>
    <dbReference type="OrthoDB" id="42161at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46182" checksum="DBCBE303A2948874" modified="2009-02-10" version="1">MKRSRKTVTVPVLASCFFLGTFLERAVAFLSLITVRYEHRTISGASPNSLLQPLVSNQCSCRSLRLFSGYGIATNYTWKEEAFEIDVTVTVPADVVAKNIIFQPTGRSIDLRYKSETKKGSNGDRSKTIVLLDGSRKLRGKVNLDGTYWVISDLQDDFAQRQVTVTIEKIVRTPKDDFEVVDYDWKGIYVDDTEEVLERKYDEPEKLNVREYAAKLGVDIDNIDMSMVDKTMFSSGMNLTQKNMDELTKAGYLSDEEVTQQADGTEYVTNEIGELERLSKPYEDEIGGSGEERMPSTKIPFLDTTSPWHNTIPVHVDKETNKTFVQQTRNFTRAAFAEDSARVSLDEPTQEVRVSKDANDPIDILTVKRLKDILKSQGLKTSGNKQELKDRLRKQVNSLMQGKQSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3F3</accession>
    <name>B7G3F3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181606.1">
        <property type="nucleotide sequence ID" value="XM_002181570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3F3"/>
    <dbReference type="PaxDb" id="2850-Phatr47453"/>
    <dbReference type="GeneID" id="7202574"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47453"/>
    <dbReference type="eggNOG" id="ENOG502QSZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075183_1_1_1"/>
    <dbReference type="InParanoid" id="B7G3F3"/>
    <dbReference type="OMA" id="ALMCTRW"/>
    <dbReference type="OrthoDB" id="565040at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35748">
        <property type="entry name" value="OS05G0358400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35748:SF1">
        <property type="entry name" value="OS05G0358400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32243" checksum="CD1708533018DDC7" modified="2009-02-10" version="1">MQVGFCVVSLLLHRPCAVSRIPARQISVRGKCAHFWSSKASVSFPLGTVKSGSHNLLLGSSDPLSDETITILGYGSLLSEKSAKSTFPELSNFRLGRIRNYRRVFGHPASIFFATGIADLPSLQIASASAEFDQDSAGFVVSAFDVPNEGLSGVPSRALLEREASYDFEKVVFAGLTKNCNPSMEGWLSVRSTDSAYIKKWGQERFDRQFRKNGIETIWHWPEDSGLRPCAVYLRHCYLAAQSMGEECFNSLLDESYLCDRSTTIREYLNMYPEVLDSVPPPELALRYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4G1</accession>
    <name>B7G4G1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_14269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182067.1">
        <property type="nucleotide sequence ID" value="XM_002182031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4G1"/>
    <dbReference type="FunCoup" id="B7G4G1">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4G1"/>
    <dbReference type="PaxDb" id="2850-Phatr14269"/>
    <dbReference type="GeneID" id="7202852"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14269"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_1_0_1"/>
    <dbReference type="InParanoid" id="B7G4G1"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="73" mass="8305" checksum="2438CE1801056B37" modified="2009-02-10" version="1" fragment="single">ALIFSHAFCSFVACPPQQKNTCAHNSTHKAHANGIKKAKRSKFVSTKGMDPKFLRNQKFAKKYNGTKRRHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4K5</accession>
    <name>B7G4K5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181932.1">
        <property type="nucleotide sequence ID" value="XM_002181896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4K5"/>
    <dbReference type="STRING" id="556484.B7G4K5"/>
    <dbReference type="PaxDb" id="2850-Phatr47695"/>
    <dbReference type="GeneID" id="7202703"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47695"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651288_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4K5"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF70">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="1">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="418" mass="47792" checksum="093A7AAF57EE034F" modified="2009-02-10" version="1">MNVSLIGKIKRGIKEICSATSNNSFPAVVDNPCWGLPSQCSLSDLLRCFEKDKVVVYETDHFLALNKPPDLRMDGHHPSTVLKLLTYWYPPPAFQNLQSKGLLEKVSEFENYRNIEGNELRPCHQLDYATSGILLVARNRQAADQARVSFEERSTRKTYLALVHGHLSVPSNIPVMRRTDIDERMGRLEEIYRQSRRKHRKDTYRGYQPAHGLFQQLQQQHNHILNLSWKEVKASGKTEPFDRAAEVFNKLQYKTLFPEDKSAELSLPTFFRDESEDPNTLFIYASVAQVPHDFAMRINPSMSNASAYLKVGDSSLDYKPSLTRCVILKHAAIRGQPVTKVRLEPRTGRRHQLRVHSALLGHAIVGDQTYKAPGSPDLTDRMCLHSQCLEIPLFEELIKVEAPDPFLVKNREILVQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4V3</accession>
    <name>B7G4V3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_14161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181979.1">
        <property type="nucleotide sequence ID" value="XM_002181943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4V3"/>
    <dbReference type="FunCoup" id="B7G4V3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4V3"/>
    <dbReference type="PaxDb" id="2850-Phatr14161"/>
    <dbReference type="GeneID" id="7202750"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14161"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="InParanoid" id="B7G4V3"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="240"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="540" mass="59376" checksum="9FF3E660309343B2" modified="2009-02-10" version="1" fragment="single">LERPTNVQSRAIPAFFTNQQLHNILLQSETGSGKTLAYLLPILQSLAVDKQGELRKLDRAKAGTKCIILCPTRELASQTVKVVENLCSHSFNWLVPGCLLGEERRKSEKAKIRKGLSLVVATPGRLLDHLTRTESLLMALKGKLEWLVLDEADRLLDMGLGEQVKQIVQRIRSNQPGSGRDGITWRSVLVSATVTPSIEKLAKETLLGGDNSWVWVKGGNDAQVAKVAAESEFSQSTPRQLAQFHMTVSAKLRLAALVGFLTQRADKGERTVVFMSTCASVNYHHALFEGMDSVLEESDSDTGKGIFGTRCPIHRLHGSVPHSERHLVLRKFTKEQIVGGKKQAAVLLCTDVAARGLNLPECEWTVQYDPPSEVADYVHRAGRVARAGKAGHSLIFLLPSERTFLDVLKNRGVKHMSALSLASTLNAAAAICGLGQSKLATSRRGEAFCTELHRRMENLIRTRAKPQEVSGQLLELARAAFLSHLRAYPTKEKAVRHIFSAKALHLGHVARSFALKEPPKKLGTNSSQSAANQEDDSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4X9</accession>
    <name>B7G4X9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182315.1">
        <property type="nucleotide sequence ID" value="XM_002182279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4X9"/>
    <dbReference type="PaxDb" id="2850-Phatr47797"/>
    <dbReference type="GeneID" id="7203040"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47797"/>
    <dbReference type="eggNOG" id="ENOG502S7PH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580722_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4X9"/>
    <dbReference type="OrthoDB" id="42816at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855418" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="471" mass="51290" checksum="CFCD970EF65BE80C" modified="2009-02-10" version="1">MNLVKSTSTLLALFLVGTVVAFTPTRHPFQAAVGRIAIPGATRIRPDGLPLRYRALDDQDDDSAMLQVQTRTPPGYDPRKAVGESEFPTAPGGDDAPGRRRLPRTAMNTRLILALLLNQGLVLAVASTLAGAALFATSGGLAAFGNLNELLRWTGTGPDVWDLTITGERLLWGIGGALPLLVLNAVWESSDDRRLANINFSTIAMVMTLFGRRTALPDEFRPASWKGQTLPTTTGGQVALQSLVLSLVTGICEETIFRRELPAVLRSFGADPVSAMIGQAALFGLGHVQPTAKAADNTVVASLQTVNGLGFGLIYALSGGDLVPCMIAHACYDFVVFFQTWTRANDQLEYAERWYKEPLPAGTEQKVRRILQAAQKDPSVLLPRIKRLFYVFDFDQNQSLSLSEVRKGVAYLAMERAGTPPPQPEVDQAFWEVVAQHESDARDDRLDLVDFLRVYSKLADGNRQRLASAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G535</accession>
    <name>B7G535_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002182141.1"/>
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    <dbReference type="GeneID" id="7202975"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47840"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848549_0_0_1"/>
    <dbReference type="InParanoid" id="B7G535"/>
    <dbReference type="OrthoDB" id="37564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad60/SUMO-like_dom"/>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="252"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="328" mass="37192" checksum="9791E2C405C52399" modified="2009-02-10" version="1">MAAVASTMNDNGLWLPGATTKEDKIERWWEVNRKHDPPLNRGATPLIERCMRVQGWNESFAKRTLRGYRQFMELKSVMNDWEETKLSAPIAIQQMWEQHILDNLNYTDDCFLLFGRVIGHDPDAILNDRATLDRIKTTKIAFQARYGGDLDPEVWDFGHSDLEGMTLDGDDLGGTPQQMARGRLPVANIDRGASLSPRARSIVVSTDEADLTGPMTEQIRVESVRSRSPTNRTRSLSKTPKSPKSPTGNDPITIFLRDTNSGEETYFSLRYRSTLRIVFTVFAERKGLSQENLKFSFNGQSLTGYETPYSLGLEDRARIDVLIGQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G597</accession>
    <name>B7G597_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182379.1">
        <property type="nucleotide sequence ID" value="XM_002182343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G597"/>
    <dbReference type="PaxDb" id="2850-Phatr47891"/>
    <dbReference type="GeneID" id="7203103"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47891"/>
    <dbReference type="eggNOG" id="ENOG502SNTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359219_0_0_1"/>
    <dbReference type="InParanoid" id="B7G597"/>
    <dbReference type="OrthoDB" id="39594at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="236"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="867" mass="96885" checksum="20E2C5E5607FFE87" modified="2009-02-10" version="1">MQQHPRLQRSVFDPRYIGAMILVTIHGVSSDAPVCEGDPGQCESGILAPCGLYLAPSTKNPETLTLHSGVDRDAHELVGEPDIALPFFDPNKNEWSAWHDMVWNIDVLDGLILENSFLSELLLPGVGTLPACSVFQGENVRLKRNHVIDSLDVHRAKDATAGSFSYHHGVTYETVRSMAAGEELFLDCLGPPPPFRRDKEKDEDDGNGDLDNDVYEDENGGGEDDEIRSLEWLQENGVCVDNIWIGPSTKLGIGNGAFTKRAVAKGTVIAPSPVLHLDRSQLQIVEQRFREDPFPPFFREHGVEYSDYVVGQQLALNYCYGHPDSNVLLLPLAPGINFINHDAISPNAFVRWSTSLTEPSDWLEETAHQLFAESVDGTLLIEFVALREIAAGEEIFIDYGETWSTAWNSHVKEWTFDGASYISAAKFEDLYGNDAIRTHMEQSKNPYPDNLTTACYFVAIEVDDEEELVEWENEALHCLRPCSIKTRYKEDGITFYTAIVYPLKSPAEPQYCGEIPDSGLFVTGIPLQAVKVVDKAYSSDVNQRNTFRHEIGIPKRFYPSNWMSADSRPLGDFSPDPLKPGEMAEIRWASSGDVATKWAYRLGLHESIRKTLLEYCDRMGITDIFRHVTTRDNALLPGADKNLELNGHNWFLQRPDKKWRSNLHWLSPGDNAAHEDYLQALSVSGFDTILRGIGEQMGMDGLVAFHVTFIAVSYSTEGYMHYDVTATGGKAYNIIIPLILANETGPELDLRSSSILGEDETESLVGRYRYEYEVASMLGDDAYHATSAVDYRASKEMRMAATIYVADVNEENAGAILNEYTQAYPPDDRDLLMSWSGRHWRKDDTTAKLPAPVSGHILLEANTDNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5A6</accession>
    <name>B7G5A6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_14449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182212.1">
        <property type="nucleotide sequence ID" value="XM_002182176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5A6"/>
    <dbReference type="STRING" id="556484.B7G5A6"/>
    <dbReference type="PaxDb" id="2850-Phatr14449"/>
    <dbReference type="GeneID" id="7203107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14449"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5A6"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25087" checksum="F718E374051468A0" modified="2009-02-10" version="1" fragment="single">MTFAAAADFEPYQLNGGLVAAVAGRDFVVLSTDTRLMGPSGYDILERNHVKIETTNSGELIVHASTKLVYAPTFVGSSGCNADCEMLKRTVRADTRAAFYHGESDIQTAAVATLLGQMLYSRRGFPFYSFCVVGGMENGAGKVYVYDAIGSYEQVGVATSGTGRELLQPILDRSFRSREVFRSTIESELPKQVMLPVAPRQVDCSKDEAISKLVDGYRSVSERDIGVGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5R8</accession>
    <name>B7G5R8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182457.1">
        <property type="nucleotide sequence ID" value="XM_002182421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5R8"/>
    <dbReference type="STRING" id="556484.B7G5R8"/>
    <dbReference type="PaxDb" id="2850-Phatr48037"/>
    <dbReference type="GeneID" id="7203026"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48037"/>
    <dbReference type="eggNOG" id="ENOG502S2CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_5_0_1"/>
    <dbReference type="InParanoid" id="B7G5R8"/>
    <dbReference type="OMA" id="FPGDRLY"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852943" description="MOSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="153"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="302" mass="33474" checksum="8C286E53912C32A2" modified="2009-02-10" version="1">MSAWLLSALTLSLLPTFSMSLAIPRVTALYRYAVKGLSEDVLDSVTFANTGDTFPDDRRYALLQQSRRDRFDGKSWLHKENFLCAFTEPELMATLQSYYRETTAGEKILTIVDRASGDPLFMGNLATEAGRERLGEMMSETSSQDVVCVTASDPSSPQHTFQFGNTSSGFKQRDGDTRTLHIVNAQTVRSLSEKIGVALDPRRFRPNVVIDDVDAWSEFDWVRSKAKLRCINSGLELAVIGKTVRCKGISVDPNDLGHVLDIPELLIKHFPEHGPYLGVYAVVDAPGKLSTGDTFEILMEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V5</accession>
    <name>B7G5V5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alternative oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_48063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182610.1">
        <property type="nucleotide sequence ID" value="XM_002182574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V5"/>
    <dbReference type="PaxDb" id="2850-Phatr4283"/>
    <dbReference type="GeneID" id="7203447"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48063"/>
    <dbReference type="eggNOG" id="ENOG502QRMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886990_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V5"/>
    <dbReference type="OrthoDB" id="4493at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF10">
        <property type="entry name" value="UBIQUINOL OXIDASE 4, CHLOROPLASTIC_CHROMOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36137" checksum="74478E7C6E4778E7" modified="2009-02-10" version="1">MKLPGSLSPLALGSIAFVTVLSTVRGFTPTVRLSLASTPFVRSTRTRPPTSLGVSNPLRTERTQPVVSANTVSTLPETKPSSPSSVFGRPLDESTKQRNRQLVHQLKSVLFDQVYRGDTMDRAFARFYALETIARMPYFSYLSVLHLWETLGMWRRAEYLQVHFAESWNELHHLLIMEELGGNGRWGDRFVAQHIAFFYYWIVVTLYAVNPTMAYNLNQAVEEEAYETYDGFLQTHAEYLQSQPAPQAAIRYYTGDDLYLFHAMHWDTRQPKEPESPVEQRRPTCETLYDTIRNIRDDELEHVKTMACLQDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6F3</accession>
    <name>B7G6F3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182563.1">
        <property type="nucleotide sequence ID" value="XM_002182527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6F3"/>
    <dbReference type="PaxDb" id="2850-Phatr48229"/>
    <dbReference type="GeneID" id="7203347"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48229"/>
    <dbReference type="HOGENOM" id="CLU_781825_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6F3"/>
    <dbReference type="OrthoDB" id="46635at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="349" mass="39462" checksum="1488F9394A067BDF" modified="2009-02-10" version="1">MNLFQPRNKENSPDDDQVTLIGSFADIIAQGVSWKDFFRACVPPRIVWTSVDCCCLTDQSQAPIDHNYAVDLVVQVPSIDSKQVLHISAQNAQAAVGTLAGLLLLLANGKDELELTFQSFATQPRHPFPPLASDTGLATVLSAKHKIVAVRLQFVDVDDSTCQLLAKTIPRMEYRQCTVEGLHQAVASNQCPSKLTISCTLQEFAKFGTGLGGNSVVRSMDLLLHFWLQGEPLHDFCRGLEHNLGLETLVIRYLDINDDGWTMLFHALRFHPTLQTLCLQFTDDFVDNFRRLTPERRTQRTQVVLDFLEENRVIQNVTWPIFQQDQELMDDIKSRLERNRGTGEEREHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Z9</accession>
    <name>B7G6Z9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PK1</name>
        <name evidence="18" type="ORF">PHATRDRAFT_22404</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182818.1">
        <property type="nucleotide sequence ID" value="XM_002182782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Z9"/>
    <dbReference type="FunCoup" id="B7G6Z9">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G6Z9"/>
    <dbReference type="PaxDb" id="2850-Phatr22404"/>
    <dbReference type="GeneID" id="7203591"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22404"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_8_2_1"/>
    <dbReference type="InParanoid" id="B7G6Z9"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012700349" description="Pyruvate kinase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="79"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="439"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="591" mass="64027" checksum="CEBB7566791F897A" modified="2009-02-10" version="1">MKLSLLALTFALGHAFVPPSFLASPSSRKVLSSSRSASVAANAADVLAKTTSSSSTPSSLMPKETTVAAVPKVAQRWRKSTKQVVTLGPASSNKEMIEKLFLAGADVFRLNFSHGSQEQKKELLIMIREVEEKYSHPIGILGDLQGPKLRVGEFSKPEGEFLELGQSFRLDLDNAKGDNKRVQLPHPEIIKASELGHALLVDDGKVKLVVTAKGDDYLECRVDVAGMIKDRKGVNTPDSVLEISPLTPKDRSDLEYMLGIGVDWVALSFVQTPADMVEIHALIDEKLPSGQFKPAVMAKIEKPSCFYDDNLQRIVGLCNGIMVARGDLGVECPPEDVPLLQKEIIDECRNQGRPVIVATQMLESMIEVPTPTRAEASDVATAIYDGADAIMLSAESAAGKFPEESVAMQQRIINRVEGDKHYRSYLKQNEPDPENTPTDAIITAARQVAKTIGAKSIVCFSLRGSTVLRASKSRPGVPILALCPFKETSRQLALSWGVYSDLPKAGSYGYTVSEEDMFNYDRPMVEKSTDDFDLVLKNACRAALKKGLVSDPDDLLVVTAGLPFGTPGAANIIRVVPAAGPSCWDGVCRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G723</accession>
    <name>B7G723_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_38866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182960.1">
        <property type="nucleotide sequence ID" value="XM_002182924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G723"/>
    <dbReference type="PaxDb" id="2850-Phatr38866"/>
    <dbReference type="GeneID" id="7203601"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38866"/>
    <dbReference type="eggNOG" id="ENOG502SD6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033030_0_0_1"/>
    <dbReference type="InParanoid" id="B7G723"/>
    <dbReference type="OrthoDB" id="38337at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="446" mass="51491" checksum="BF0289521889B586" modified="2009-02-10" version="1">MTSIAEFDNGKRHTKKGNDRFTNTLIPVLRESATSMYQSGFDVDVYLICHYPVSTERYRQVLAALPSHESGNANTVEVSLTVWDEATPIGYAVEHSTRSIMNVTRGLARQHRYVIKDKLLHYDMFVAYEDDMVVHGAQVQQYRNVSDALYRLRQAAPSRLDNTYTIAEMNRQFHGPMTATQLSRMIPGWIRVEVALDGWKPKRTLELPIPRDFRWNETGEEVSLDPSICCQIGVTSSNAHMPSAPHIEDLYFWETTIDALHLRKMPEIPFSQLDWVVLQAGNTEDWYEDTKFIVGRYWSGTDGYFGHQQDPPDSTLSHYINNQGGWMATRRQLHEWHSRWCLGGFLPPYDPPKFHFDGLDSRSVEYWSGGIQIVGVKACNLQRIIPLQPQIFARHLLYHASNNKQRQRTVQARSAFTKIQDLWGQLNTVRKNAEQAIRKERDEFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7A6</accession>
    <name>B7G7A6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182996.1">
        <property type="nucleotide sequence ID" value="XM_002182960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7A6"/>
    <dbReference type="STRING" id="556484.B7G7A6"/>
    <dbReference type="PaxDb" id="2850-Phatr48481"/>
    <dbReference type="GeneID" id="7203765"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48481"/>
    <dbReference type="eggNOG" id="ENOG502S73D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720546_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7A6"/>
    <dbReference type="OrthoDB" id="70850at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="384" mass="42350" checksum="E78C5B8FA72E31CD" modified="2009-02-10" version="1">MIALEEARNLALTVWQQQQPPPEVWSVVSGVAAFSTTLAASTWCQQRILRMSTGTLAPFPSLVGFATVCVASVVSHRVSLSTLQVVRSGDTTPWRFWEQSFQRGNSFGNNSNSNPHASFSYADKHLELPVGRVSWHTLRICCIGVVAFKVLLGGRFWAIAPSSYTHLGSFARTSSWMNGSIPATARYASSAERLWVERMGRRIGCHTCGSRMAHSRAAVKFVGDHMPPKAVANQQNARWIRRLLGNPVQFRFFPQCVPCSSKQGTILGKATSDLRAAIASPASLFTRRSSKLPNLARAGGGVQAYNHGLRPRLHHLAGGVVGGVAVLGANEADLMDENRYRYAQWQHDLHQALLQETPQQWLEGFRRGLMAVREKVWPNDDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7N6</accession>
    <name>B7G7N6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183177.1">
        <property type="nucleotide sequence ID" value="XM_002183141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7N6"/>
    <dbReference type="PaxDb" id="2850-Phatr39045"/>
    <dbReference type="GeneID" id="7194725"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39045"/>
    <dbReference type="HOGENOM" id="CLU_753289_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7N6"/>
    <dbReference type="OrthoDB" id="48979at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="40628" checksum="C36F981F9F53EDD9" modified="2009-02-10" version="1">MVKPLTDQPGIDSDDAKIICNEFHKHLDVDEMMETARDSPWWVSLSESSDVNVIATPSSDPSDGIGLILSNSFTTKNFSYIKEGALQHPQVKASSDKVAADWTNPTSSRKISSAVSSLQLSDDISACVKPHNSQKNEVVKNPNNSKQIQSPYLLCPVKSHGDGQGVLRFSGFDLPQIKASTLSPSTFPPTIASVLQALEPTPFAPGQKSLRRVVSKSESTTSSCKDLRPTYTTSRQTNAVFADASVVQDLPSAVCTVPSTVSPCGKKLSPLRALSAYNFFFRDERERILHGGADDWTAARHAALLTSHWLKDRTKKRQHRKSHGMIDFTSLSKLISMRWKNLHPDGKGFFRQVAAADWRRYQDELAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7U2</accession>
    <name>B7G7U2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183206.1">
        <property type="nucleotide sequence ID" value="XM_002183170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7U2"/>
    <dbReference type="PaxDb" id="2850-Phatr48600"/>
    <dbReference type="GeneID" id="7194869"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48600"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072711_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7U2"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48215" checksum="28F6F3BF5A9DCA64" modified="2009-02-10" version="1">MGITKMQSEHLRLSKTIFTTSKTTLQQGVHLVMKAHTIGLILLQTTNAFLSPYGRIKNMNSIPGRVETVESLRGGALEALPAEVVNLPSTVTSLVTSSLLSGPYGVVALAAISAAVILPLTQVKNMYGVSVGYGGSVAAIAYVLLQTFVPAKGDISHLLLGSSLFYGIRLASFLFVRDVAGWKPPASREEPSRMKRVPFALSLAIFYGLMTTPLLYAMRTPSAVGTSLHRVSMVGTGIAWAGAILEAVADGHKFLSKLNVDPKSKAFTGPSTGVYTMTRHPNYSGEVLFWVGTFVAGAPSFGKSIIAWLSSTAGLYGIVSIMNAATKGLEKRQGEKYGGQKAYETWKSDVPYPLVPLIKAYPLSPLLAREIGYGRYFNGLKDFLSSQPSVANKIELVGKEDPTVTGNFEVSVAATGQLLHSKRQAGQGKATSPGERAAILEQIKELLDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G833</accession>
    <name>B7G833_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="7194863"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48680"/>
    <dbReference type="eggNOG" id="ENOG502R044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023382_0_0_1"/>
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    <dbReference type="OrthoDB" id="10260867at2759"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051918">
        <property type="entry name" value="STPP_CPPED1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143:SF4">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855880" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="571" mass="63702" checksum="449C997CF0BFD287" modified="2009-02-10" version="1">MVSWTIAAAFLFTPTAAWVSRPVSQVRSSPSMLRMSSDQFTVACLGDLHLDPRYMEDYYTGRDQWLNIIDEAKADHGNVALVSLGDLGESKSVRPEETSELFAGTTECHELAAEFLQSFGVPYEVVGGNHDLEGIDEFATDKENLKMFLEKHGKPTPHFSRKIADKTLLVGLSSTVFRDAEYTSHEVTIDDAQMAWFEQTLKDHPAADGWRLFVFTHAPPNGSGLRVLQENHVVNGCCWLNHSNDKKCRKFIELVREHRCIKAWFSGHFHLGQDYQDSITFPTIDPKDGPYPNRGSCTFVQTSVMRSGSSRDGRQQSRLIRGNKDGFEICTVDHKEDGKVRVDATISYRGDTNEVGIYEHEDEVKKGDELFKVYAPSAGDDLHAPDEGHVRYNDDGQVKIDLDVTEDTKAWWYMSDGRVLGMLKGMLIEYDRSTLAPLGLVVGADELVGKRVAVIDSGLDDEECVISDELGMEGIECGGEPGREQAVILVDKDDGSVVVVQPNEDGSYWRKIVRNKMIRMKEVRRVKAAKEFAKSLMDKEVEVVSSWGPYTTTSGTAKKTGVQGLTAPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G859</accession>
    <name>B7G859_PHATC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PHATRDRAFT_39265</name>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183282.1">
        <property type="nucleotide sequence ID" value="XM_002183246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G859"/>
    <dbReference type="PaxDb" id="2850-Phatr39265"/>
    <dbReference type="GeneID" id="7195194"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39265"/>
    <dbReference type="HOGENOM" id="CLU_805263_0_0_1"/>
    <dbReference type="InParanoid" id="B7G859"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="251"/>
        </location>
    </feature>
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            <begin position="264"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="38077" checksum="BA5A34EBFE495477" modified="2009-02-10" version="1">MPRHSKCWDEPSEPMDESSCNALQDAEDSVVRLVEDRKLVRQATSRQSQATTTLAEMVLSLSSALHHVCPDSHGSARVAQVAQGVESLKLRQTKATRKTEQLVQKLQSTINAQQNELEILRARQQQQQQQKHTYQRNVQVQVSRWPPAHGPQDEKTGRMPDVETSTQRTETTHTTSFDSPSADSHSTTEASPVRTETCPTTDPESESSPLLPTSPARSHNDSALPVSMPAPVPTVPTPTASPVSLTEDPNDANILPALLDMHTLLDQPPDSDDMSALTLHTTRRPSSSPHDPSPSKPRRNKVRPTKATEGTTPQDNHPTKTTSTSRRRTKIPVEITLLPQERLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G898</accession>
    <name>B7G898_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183433.1">
        <property type="nucleotide sequence ID" value="XM_002183397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G898"/>
    <dbReference type="FunCoup" id="B7G898">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G898"/>
    <dbReference type="PaxDb" id="2850-Phatr39304"/>
    <dbReference type="GeneID" id="7195037"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39304"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048369_0_0_1"/>
    <dbReference type="InParanoid" id="B7G898"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="41767" checksum="DF98602965F03C4A" modified="2009-02-10" version="1">MWGTDKAGASILKNPNDLDTKRFDVPVQIDDVASRFVDNNNNHNNHITIDHVVCGPTDTAWILTDGRVWVHGENQSGHLGVGHRNVVPQPVPLVWPDPDTAPRIASVALGASAAAWIDTDGDLYTTGYGGSAFAGRGALGHGPDHDGRYVLQPTLVTSLVEDGVYARQAQVGEAHLTVLTTEGEVLTAGAGSYGRLGNFETIDQLFLEPVEILTSGVTQIAGGKSFTLALHEDGVLYGWGRNHKGQLGTGLGLAVDMYAMQAVPEPIEGDELRHRVVTQVAAGHSHATCLTESGEVFYWGDSVYLEPTRVDALLGVRIVELACGEHYTLCRDEHGKLYSFGKGKTGVLGQGGAVKQANQAAHLEALDGVSVTAISAGWKHAACLATNSTPTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8C9</accession>
    <name>B7G8C9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide pyruvyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183324.1">
        <property type="nucleotide sequence ID" value="XM_002183288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8C9"/>
    <dbReference type="PaxDb" id="2850-Phatr48784"/>
    <dbReference type="GeneID" id="7195098"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48784"/>
    <dbReference type="eggNOG" id="ENOG502S3FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512408_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8C9"/>
    <dbReference type="OrthoDB" id="46445at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="532" mass="60516" checksum="DABC61FF714A822E" modified="2009-02-10" version="1">MTSSRTMSQLSTEDVNEETQKRSEEDICNIYPVIVLPRIRSGRVTWFAAYQLRMVAILQKHSRNSTPSSRFPRAVWPFLFCVVIGLMLLTTQWWLLLSPVDSSLSEYRAYLSTKEYLRPTSAYLSAVRESPDILYFTSRPPDPIPLFSVESIPILQRHACIAKIREQHDKVYASFERIGMSDRALLVDPAYHSNVGDHMITLGELEMLRKLGYGTLDEPSAKVAQCSFLQAGNYAPPCHHFSTGGALSNIISISNPPLAFWHGGGNWGDMWPDIQIARMKSMEPLLRSNYTIISMPQSLYFQKSSREQEFTSILKKHIELGLGASSTLVDPREGRRQTASRVVLSWREHESYDIAQRLYPFATHILVPDIAFQLGPYSPVASQEDFLKVDLVLLLRDDRESMYATQRNRRAVRDILSDLPNGQRLSFSIVDWTDRSDRFASKDILFTSSAIQLLSMGKVVVCDRLHAAILSYLSGIPFVYLEQRTGKITKTLQVAFELNETCLDGSKAMWSQAYNLSDAVRQGVEFLDRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8J4</accession>
    <name>B7G8J4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_48834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183481.1">
        <property type="nucleotide sequence ID" value="XM_002183445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8J4"/>
    <dbReference type="PaxDb" id="2850-Phatr48834"/>
    <dbReference type="GeneID" id="7195133"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48834"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032266_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8J4"/>
    <dbReference type="OrthoDB" id="206240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="335"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="597" mass="67351" checksum="B75F4259CD6ACF5C" modified="2009-02-10" version="1">MTCLAHHHWGGRLVSRIAMIGLVLILVGLNLWNDSAPINPTIRSSDNSGTQSSSLSRSFPLPYRNDTHEGNKGNGNENFTSPSNLSTTPNNANSSSKRTISPALQPRSDASKDSIFTVQEVKSAEALSKMESESLSKNLSSALLSKHFPTADQRVRFYMSSWYEPPCDQDELLEIVKYVGSRGNEGSTAANETGEEQKDDSMTQFIPSFSLHRHVQSPQISSSIIFKGAARADTDVVFALDKSALDSCEFNPRPDQKKILESIYCPELRDTLLLPYQNQIGLTNTSKNNELSVVLLAQVGDALSSRAMDDFGKPHGYSAQPTVPHFTKVRLAWDNVTARVSLMKASPRSCSTLQTRRINRGKLEPIIWKMGIKRHYKGVEDVPSEDVPWEEKRDVAVFRGTSTGDFDQKMPARERCRQNQRCRLVLDYHNSSLVDAKFTNILSRSNLPLAIDGIPINGSHLQRYEQLRYKALIFMEGNDVSTGLKWGLYSNSVVMITKPSISSWAMEELLEPYVHYVPLRDDLSDVETQMKWIVEHDREAKEIALRGQLWMHDLLYAEESERDNAAINEEILRRYQTHFRPGIAVKEELLFYPKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G936</accession>
    <name>B7G936_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183699.1">
        <property type="nucleotide sequence ID" value="XM_002183663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G936"/>
    <dbReference type="PaxDb" id="2850-Phatr48981"/>
    <dbReference type="GeneID" id="7195253"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48981"/>
    <dbReference type="HOGENOM" id="CLU_239778_0_0_1"/>
    <dbReference type="InParanoid" id="B7G936"/>
    <dbReference type="OrthoDB" id="207211at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="639" mass="69580" checksum="F92120723A04EB60" modified="2009-02-10" version="1">MLEYGHHSQIGFEMGSDIESRSDVSSAKELQKATDRPTAMPRNASTPANTISEVTEQAAVDHVPSEDEQGPLVDAGTHKRPSDSEILSTPRRPVLGRLDSTMAVADQGSQSSLSIESATALAATEPDRLVVDRTPESTSAGTPVRERSSQTPARRTPLSSGKKSGRIVIYDPNEDSSTEPGMYAPDRGEIEQEEEVADNLSRSDRAEEIVDSRKARRSAGSLPATPDDKEAGFLLHDTHQTGTPDIDTVRQSQSLLRSGRLQRNTLLESDRQESDSESVASVVAKVLDDQVDWSSKTVIQLKQELESRGLSTRGKKAELIDRLTETTSVGKKDEGVQEETIKAESDTTSNHERLDEETSNDESSEGDTKVPTEQVNWSSRTVIQLKQELESLGLSTRGKKVELVDRISAAKSAEDEDEEAVDGTPEEAVPSELEDTDGEAVIDWSQKTVADLRRELSRRNLSTNGRKVELVARLTHGDEEVDGVSVASSESAGQDEGIDEGNGDVRIDWSKKTVAELRAELGYRGLSKDGLKADLVARMEHTTAGEKTVTPTKKPATRTNEETSVASSTRPGSGRRTRARDHEKEKQDDPVGIDYASVASSTARPSRNRTRAQANDIGSTTGTRASRRATSRRSKRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G986</accession>
    <name>B7G986_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183593.1">
        <property type="nucleotide sequence ID" value="XM_002183557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G986"/>
    <dbReference type="PaxDb" id="2850-Phatr39646"/>
    <dbReference type="GeneID" id="7195282"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39646"/>
    <dbReference type="HOGENOM" id="CLU_1163068_0_0_1"/>
    <dbReference type="InParanoid" id="B7G986"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="239" mass="26682" checksum="144857ADAC2115F7" modified="2009-02-10" version="1">MLDDRGSCGLTTKAGSVPYNAQAIATKTSYFCAILQIETCPVNFVRNSGTRDVCPSRSLNVNSSTFSTYVHKCRDFAEYRSPNRRCVFFARQSSRVPNQSEKVGVSACVPVLLGSRESARAPARLRVLPVTERFHRTVPPVGTRRWKAQNSRALTLVRVVGSWRVPSNCPFAPFLLLFSFPPKHPQYRSHNPHTSHQYDCEYFGRACNTEYPTDPASASDLSASNRSTVGTRKQKAIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9P8</accession>
    <name>B7G9P8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183812.1">
        <property type="nucleotide sequence ID" value="XM_002183776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9P8"/>
    <dbReference type="PaxDb" id="2850-Phatr49164"/>
    <dbReference type="GeneID" id="7195622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49164"/>
    <dbReference type="HOGENOM" id="CLU_1535456_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9P8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="175" mass="19472" checksum="0BFBA0D80C9C779E" modified="2009-02-10" version="1">MNLPSHLQDLIRNGAHIEIIVDNAKPQGVKRRRGSNPSLSPRSLTKHEKAELRWDAIPQTAPMKIPGRGWQTCSPTPSYKTSLTHCQSMRQTTAASAKHLQALMNISALPLKVPQRRSSLEDMDSKISTADMIAKVLEEIDFNADEFQSDFEDESDDEFCQCAPEQGSARTARIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9U1</accession>
    <name>B7G9U1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_42276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183951.1">
        <property type="nucleotide sequence ID" value="XM_002183915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9U1"/>
    <dbReference type="STRING" id="556484.B7G9U1"/>
    <dbReference type="PaxDb" id="2850-Phatr42276"/>
    <dbReference type="GeneID" id="7195516"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42276"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9U1"/>
    <dbReference type="OMA" id="TDCNVML"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="245"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="551"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="735"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1263" mass="136610" checksum="95BC4B4A4E87FEA0" modified="2009-02-10" version="1">MTSTSATTIIPGDGKFHFAIDRGGTFTDIHCRLPNGDEIVRKLLSEDPSHYQDAPTEGIRQVLAEFDTERLYNRGIPVETSQIGSIRMGTTVATNALLERDGARMALLTTKGFEDLLEIGNQARPNIFDLSCAKPSLLYEKTVAIDERLVLAQFTPDEYRDRYTAHEGVTGETVYVVREPNLTAVRAVLESLKADGITAIAVCLMHAYVYGAHEDMIGALAESVGGFEQISLSHRVMPMVKLVSRGHTTCAAAYLTPKITTYLLSFQKGFDANLANVPLTFMKSDGGLAPVHSFGGHQAILSGPAGGVVGYAKTSYKPGFPVIGFDMGGTSTDVSRYDNAWEHVLETVTAGVAIQAPQLDIHTVAAGGGSRLFLKRGMFVVGPESSRAHPGPVCYRKNGYLAVTDANVVLGRVVPRYFPSIFGPNEDEPLDVDGARAAFEELTKLPEAQGRSAEELAFGFLQVANEAMCRPIRNLTQMKGFDITTHTLACFGGAGPQHACAMAKALGMKRVFVHRFGGILSAYGLSLADAVHEEQEPTAETYHGGISESGQTRLQALAEKAQSMLTVQGYDASEIVTERFVNMRYEGTDNAIMIQETADATLDDSFRALYMREFGFVLQGRDILIDDYRVRAVVPGATPPQWPSPENIGAPTPIDTTKAYFEHGWEDVPVYKAEDLLPGHAVKGPSIIVQPISIVVLEIACEALVTATGDLEITVGNCHEQVVEEESSEAQIKEDPVQLSIFAHRFMGIAEQMGRTLQRTAISVNMKERLDFSCALFTKNGGLVANAPHIPVHLGAMERAVSFQVEYWNSEGRESIKEGEVLVSNHPQLAGGSHLPDITVITPVFHEGKIIFFVASRGHHADIGGIAPGSMPPHSNKLEDEGAMIIAFKLVRDGKFQEEGITEILQSPGKLPGNSGTRNLRDNMSDLRAQVAANNSGIRLLTELVQEHGLHHVEAYMHFIQKNAEILVRRMLRDFCKEHGNRAHAIDFMDDGSPIELTIDIDPNTGSATFDFTGTGPQVLGNHNAPPAVTYSAVIYSLRSLVAEDIPLNQGCLAPITFIIPQNCLLNPSSDAGVVGGNVLTSQRVVDVVLKAFQACAASQGCMNNLTFGDKEFGYYETIAGGVGAGPSWDGPSGVHTHCTNTRITDPEILERRYPVLLQEFSLRRGSGGRGRHQGGDGVVRELEPLRPLTMSILSERRTLHPYGMAGGEDGACGKNLLVRKDGITVNMGGRCSSSINTGERLRIETPGGGGYGAFPEEKKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA62</accession>
    <name>B7GA62_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184015.1">
        <property type="nucleotide sequence ID" value="XM_002183979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA62"/>
    <dbReference type="PaxDb" id="2850-Phatr39989"/>
    <dbReference type="GeneID" id="7195583"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39989"/>
    <dbReference type="eggNOG" id="ENOG502SBEI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006335_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA62"/>
    <dbReference type="OrthoDB" id="198474at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36383">
        <property type="entry name" value="OS09G0529350 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36383:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="277" mass="30664" checksum="B039D9EE45DEEF21" modified="2009-02-10" version="1">MCWYQLDSSRQSKVASFSSASEQRVRPFYVHLERRADARVQSMLYQRWSCPLRMVKLTSTTVLVLWLWGGTLCGISHRCDAFSVFTRTRNRNGPKRTVTTRRRRSFGLPYSTDSRLYSDKNHNNNDNKFGFGQRVASVQCAVLGALTGSLAVAPVVALHDLIFGSGVAQWEFDTDTAAVEGALFAIVYRYCVREDDNAQLAQGVVGAFALVRTLSRIVVPSYCTALPLRCGPPLGYLDWNILGELAGNGAESAVLFGAVAAAMEWATNRKYIAKFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAD4</accession>
    <name>B7GAD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_15952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184055.1">
        <property type="nucleotide sequence ID" value="XM_002184019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAD4"/>
    <dbReference type="STRING" id="556484.B7GAD4"/>
    <dbReference type="PaxDb" id="2850-Phatr15952"/>
    <dbReference type="GeneID" id="7195767"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15952"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_3_1_1"/>
    <dbReference type="InParanoid" id="B7GAD4"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="123" mass="13756" checksum="793D5D3830AB4DDF" modified="2009-02-10" version="1" fragment="single">MDRSVPNPFGNSDLTKYWNQRRRLFSRFDHGVQLDDEGWFSVTPEQIADHVASRLYQLSEARPMVVLDAFCGCGGNAIAFAKLPNVTVLAVDVDRAKLRRAAHNAAIYGIPPHKLAFVECNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAE9</accession>
    <name>B7GAE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_40080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184184.1">
        <property type="nucleotide sequence ID" value="XM_002184148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAE9"/>
    <dbReference type="STRING" id="556484.B7GAE9"/>
    <dbReference type="PaxDb" id="2850-Phatr40080"/>
    <dbReference type="GeneID" id="7195774"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40080"/>
    <dbReference type="eggNOG" id="ENOG502SVWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263782_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAE9"/>
    <dbReference type="OrthoDB" id="49630at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856015" description="WW domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
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            <begin position="354"/>
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            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
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            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
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            <begin position="556"/>
            <end position="593"/>
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            <begin position="612"/>
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            <begin position="667"/>
            <end position="692"/>
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    </feature>
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        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="743" mass="82458" checksum="341422530903B45B" modified="2009-02-10" version="1">MRFDQRTIVVLLVSTAYASWPTTGGGGTCGVEASAPFNPGTYYGNAYAQGNERNVNRNGNNAWPAQTSPQESAYDSYGQSSTAEPVSDLPPLPEGWSEHLDPASGQLYYYNANDGTTTWDRPLRLEDEAKAEEVQPPETNTRQNLSGADESRDNDNRATRMAESDVKETHADKMLDAESPQESDHEHKQHSSEDAWRNSASWDSPGEHDPESSPKEAPAEPERGAIPELDQHGWENQNMATADNSATEDFQQEGPGRDTGHFPAQRQPVVDNEQRLEGFSESQLNVDRPDQGPPTSHTGSWGAPRSVEQPRREQDVHERPYEPRSDHVSADTFGRHVPDANRPQPEKQLLPVQHQDQYGVNPRSSVFGLVPEPHNPQQYQRTSPQQSIHRDPEQSVPIQEREQYQERPGTAMPPRQQIMQQHPYGQQRPTHPQQLQQQGPPSQSRVLPPQYQQQQPHPQQQQQQSHHGQYGGPYGQPYGGPYGQYGQPSHGVNTPRGYGTQQQSQQPQRQLISEDTTRPVKEALGRTWQNILGLSNRTKEAVDHARESVVTGAKGASQSLSTTSASWWGQAKNTFGSVFENENGQPSQYSLSGQYGGQREQVIRGPPPGYPPQQGGHPAHGQPQYPPPMHHQGGGYPTYPGQQYPPGYGPPQPRSDPSYPHDPQYRPPAQSQQPPLQAQWGQQQHYPPQYQQGGPGGPRGGPGSPQQRQPQQNEQRPPPRPQGGPSPDTDDPWQHPGLGTDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN3</accession>
    <name>B7GAN3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_15977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184107.1">
        <property type="nucleotide sequence ID" value="XM_002184071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN3"/>
    <dbReference type="PaxDb" id="2850-Phatr15977"/>
    <dbReference type="GeneID" id="7195814"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15977"/>
    <dbReference type="eggNOG" id="ENOG502QU3S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613204_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAN3"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="108" mass="11812" checksum="69EFFCAFE3385C1B" modified="2009-02-10" version="1">MGQQCFVLSDPKLPDNPIVFASPGFYKLTGYTSREVLGRNCRFLQGPGTDAKAVDVIRKAVGTGSDATVCLLNYKADGTPFWNQFFIAALRDSDNCIVNYVSFAFFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAS7</accession>
    <name>B7GAS7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_23260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184129.1">
        <property type="nucleotide sequence ID" value="XM_002184093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAS7"/>
    <dbReference type="PaxDb" id="2850-Phatr23260"/>
    <dbReference type="GeneID" id="7195836"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23260"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="B7GAS7"/>
    <dbReference type="OMA" id="QLMGWLT"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF49">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="10"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="492" mass="53923" checksum="B1ABF7C0669E3F97" modified="2009-02-10" version="1">MEISRSTYIYCLCACLNSCNLGYDIGIGTQAGRLIQDDLGLTRVQRELFVGSIDFWAMFGALSAQYVSDTYGRRKTFLVAATGFIFGVVITGIAQTYSVLMLGRMLVGLGVGVGLAIDPLYIAEISPAKHRGELVTWSEIALNVGIVLGFSMSIILAPIADGTEWRWMFFAGTIMPIVMIALVLKVMPESPRWLVSKGRETEAFEILQTIYPKGYDVDLVVHDMKEAYVRDRAVEHAAGWQIIWNPTPAFRRILLVGIGVAVAQQAVGIDSIQYYLLDVLEKSGINSEQKQNLLLIFLGMVKLLFIVVGGKLFDIKGRRPLLFISLIGMAIALLMISITFFIASSTSSGFIIFGLGMYLAAFSVGMGPGAWLVPAEVFPTSIRAKAMSLSAFLNRATATLMASTFLSTANAIGWGGFFLLLSIISLLVLGFLWIYLPETKGRSLEDMSTYFAEITGDNSILEAEVRISEARDPAVELSILKKSQRTTDREVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBJ1</accession>
    <name>B7GBJ1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184538.1">
        <property type="nucleotide sequence ID" value="XM_002184502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBJ1"/>
    <dbReference type="PaxDb" id="2850-Phatr49812"/>
    <dbReference type="GeneID" id="7198472"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49812"/>
    <dbReference type="HOGENOM" id="CLU_2390773_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBJ1"/>
    <dbReference type="OrthoDB" id="45673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="94" mass="10465" checksum="A3775E06BA9766D8" modified="2009-02-10" version="1">MFGARHLALSRTSRLAPVWTKNALRTLATESAVVAPEKKTGAGLWQRLTSFIVGAGLTGVFTQYYIFEEVKNGNLLMLAKQKELETRIAKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC81</accession>
    <name>B7GC81_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_40716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184675.1">
        <property type="nucleotide sequence ID" value="XM_002184639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC81"/>
    <dbReference type="PaxDb" id="2850-Phatr40716"/>
    <dbReference type="GeneID" id="7198521"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40716"/>
    <dbReference type="eggNOG" id="ENOG502SC27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GC81"/>
    <dbReference type="OrthoDB" id="57119at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="542" mass="61749" checksum="82E652B0F813269B" modified="2009-02-10" version="1">MTQADKLLSYLENTPEISFCAIYDDPDSPLFTHCGLFYHSRLVGPSIGCGLDAYRNYSQSKEFNMRLTITDGDPKQYRTFVDAIPTFYPLCKHKLCHWHLLYRSNLMKVQTGKCGVKATILFRVVVLWIESWMTKIETQEEYELSKRLLADWLATPEAIDVKLGGMGQTIVSQINAYMTLNSALKRRGDGVRPSFSVPKATQVINKGTQPRSKKRHQKAVYNLNAAKTRKPAYYANIRDLVDYIQDSLSKDFEAVASFVLFCPNADQFWVKQATRKSKNTDIRKINDSSYYKYMIPQFERTRIVELVNIDGTFYLVCSCGKFQRQASPCAHLYKVLGQSPTSTDVSVRWTKHWDVYLHRSGHSDLSKHLEDLYKQERPGPVFVDSGQWVIGKGEKGSNFFETSLPYKPPVIRDFNRWAVSSQTTGADLSGTKNTTNMYFSSGMAVTTESVSSTKRMFGSSAFVHNFHFYQEMSKLAGFDMEAAESMNIAMQEALEKVQANVAKRAGKMDYTIGPAITKDHVGLRLKPSYSPKKRRKPNLQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCI2</accession>
    <name>B7GCI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184814.1">
        <property type="nucleotide sequence ID" value="XM_002184778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCI2"/>
    <dbReference type="STRING" id="556484.B7GCI2"/>
    <dbReference type="PaxDb" id="2850-Phatr40822"/>
    <dbReference type="GeneID" id="7198769"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40822"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835398_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCI2"/>
    <dbReference type="OMA" id="IRAKLHM"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="333" mass="35476" checksum="7F28CEA7923F7280" modified="2009-02-10" version="1">MNRWFGSESPASAARNDELPSDEAEKGTTMPGMVHRAERVLEQATSAGIRGIPSRLLRDCYGLVLLSGVSTSFLLSGSLATGIVLAKADPPSSSVPTERLSCPTASSKAEIANPSRVPDNDDTVEWTYPCACVVSGKGWGLSVGVVYQDIMIFLMEPSALQFYGNRLGVSIGGHVGITLGVGRNLGVSLGRKGGNVSIAWTKGAAAGVSVDGGVVGVRPQVNADFYQRPGITAQQILLEHHRNNLILPASQAHVLDRLYEKLHALVRQSQREEGAFAPAPDPAEAQAIQDAIQEKGGLRQASTQDDQMERQARKVKVSNCLQEYDTDQNASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCK2</accession>
    <name>B7GCK2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184824.1">
        <property type="nucleotide sequence ID" value="XM_002184788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCK2"/>
    <dbReference type="PaxDb" id="2850-Phatr40843"/>
    <dbReference type="GeneID" id="7198701"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40843"/>
    <dbReference type="eggNOG" id="ENOG502SKKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002237_1_0_1"/>
    <dbReference type="InParanoid" id="B7GCK2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="581"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="903" mass="99644" checksum="584CEDE8F50AE24F" modified="2009-02-10" version="1">MTTKSTPKDLIDSFPHSKLTPIATATTKPDYLSLHQLQYEINDNAETLSSTLGDGQHGHLFLVISEPEYLAMTDGVPCIPPVQPPFDPVHAANATAPQIVEANRQNDKRQKLFDLYHNAIKAFRNQLLEAIPIEYIESLGHPTRGFNKVSPLEILSHLWENFGKIQASDLIANDERMKAAWHPPTPIQQLFQQLEKGNQFIIASGQVMDERIIARIGYQIIEKTGLFDLASRDWRYKDEADKTLANFKKHFQKANKDLALTATSSSAGYHTANQSTVTKGKLYCWTHGIVHNTKHTSATCEKQALGHKTGATLHDKQGGSTKTYQYTPPSSVAPNTPPLASSPPFFPPDAIADTGCTGHFLSTNIAHIHCQPTVPGINVVLPDGRTITSSHITELNIPSLPPAARTAHIFPGLSNGSLISIGQLCDHGCTATFTSDTVRIELNNTVVLRGGRSPYTRLWTLDSPVTPNPPATELHAPVHDKNFANHLGDHSGTLADRIAFVHASLFSPQLSTWCKAIDEGRLTTFPDITSAQVKRHPPQSVPMVKGHLDQQRSNLRSTKPKVTLSASVDPDDINFDTNPVVQDPPAARTQFLYADFAEVTGKIFTDPTGRFVTTSSSGNAYMLVVYDYDSNFIHVEAMKNRTGPEILSAYKRAHAMLSSKGLRPQLQHLDNEASTALQQFMSSVDIDFQLAPPHVHRRNAAERAIRTFKNHFIAGLCSTDKNFPLHLWDHLLPQAIMTLNLLRGSRINPNLSSWAQLHGSFDYNCTPLAPPGIRVLVHEKPTIRRTWAPHAADGWYVGPAMNHYRCYRVWIRETTSERISDTLTWFPSQVKMPSTSSRDTIVAAAHDLAHALAHPSPTSPLSPLSVHEREALSQLSDIFSKAANPVDSSLPVAPTATLRPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCN8</accession>
    <name>B7GCN8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_50026</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184837.1">
        <property type="nucleotide sequence ID" value="XM_002184801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCN8"/>
    <dbReference type="STRING" id="556484.B7GCN8"/>
    <dbReference type="PaxDb" id="2850-Phatr50026"/>
    <dbReference type="GeneID" id="7198724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50026"/>
    <dbReference type="eggNOG" id="KOG2349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_3_1"/>
    <dbReference type="InParanoid" id="B7GCN8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF3">
        <property type="entry name" value="SODIUM_PROLINE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856087" evidence="15">
        <location>
            <begin position="40"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="741" mass="79913" checksum="D1CDD2A80D4FF3BB" modified="2009-02-10" version="1">MVASFSMGRNSATWSVSPCTRILLLTLATWNTLPSLVQAECLANTEFNDFFEGLVGAPIPSEGSCCMFDVCGLECPVDVPEPSNGFGIAVAISIVISFLIGIATFFVVKGQSVNFFVAGRSLPLWIVSMTLAAQSIDSNAILGNADLSYKFGFYDGAVIPIGLGLSLILNGIFLAHHVNNDEVLTLPDIFAKRYGKVVEILVSLTTICSFLMLLAGNLVGFGAITSYVWGISDTAAIWIAAGIVWVYTASGGLFSVAYTDVVQGLMGWSGCIVMAFWFIANEEPNAPPPSIGYPLYVYPDNIGDGGVCDMYDGVPCAVTADACCYNIERWCPEFNVTGQCERFDRGAYPVGDQRIFSDQMSNFRALTPFPNAIFWNWATIFILGFGNLAALDFQARCMASKTPRTARIGCIIGGLFTFLIGIPFAYMGAISRVYYGPDSIHAEFEVDTCLSQLALPTCGLWLPDKNAFIKLLTHQAPDFLGGWCLVGIVAASMSTADGAILAMGTVFAHNIMRQFDEWIPNLVTPDNLLVTARVATLPFTLISTFIAAFYRSSHSAGATGYLLIVAFDIVLATVVVPLFGCFYCKNPSPRAAFVAIIGGAITRVVLEFALPKDGFLLLPYDAPEFLNTGPGASTGTPVFWDVDPGDMWDETVEPCVQESFEDFTGVDSLSAFLVCILSFVSVQTIEHCTGKPLFSFAGMQGYHKDTTEHPLKGSSIDKMDETAFQDDTTKRGNPDADEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCW3</accession>
    <name>B7GCW3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_2032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184871.1">
        <property type="nucleotide sequence ID" value="XM_002184835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCW3"/>
    <dbReference type="STRING" id="556484.B7GCW3"/>
    <dbReference type="PaxDb" id="2850-Phatr2032"/>
    <dbReference type="GeneID" id="7198685"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2032"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_3_0_1"/>
    <dbReference type="InParanoid" id="B7GCW3"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48233" checksum="CE8B1163FDFC4C32" modified="2009-02-10" version="1" fragment="single">YERYDVTVDDAEADRATEIKIFSIRRPHMRAFHVAWFSFFWAFTIWFAPAPLLKEIQKTLGLTRKEIWTSSITNDITAIFLRILIGPLCDVYGARLPMAAVLVLASIPTAMVGLIQSAAGLSVTRFFIGIAGSSFVMAQFWPSRMFTRELAGTANGIVGGWGNLGGAFTQLLMGTILFPAFRNLYDGDSEKAWRVICVIPAAVAFLWGIAVPWISDDAPMGNYGEMKKRGAMDRILMTTALRQGAVVNTWILYVQYACSFGVELVMNNATVLYYTDEFGLSTEDAAALGFIYGSMNLFARGMGGYLSDQLNLKFGLRGRLWLQTCLLVVEGIVIIIFPFADTLRGAIVTMCIFSIFTQAAEGAIFGVVPYVTKLYSGSVSGLVGAGGNAGSVIFGLGFRSLSYRQAFIMMGCIVIASSGLSAFINIPLYAGLLWGKDNHSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD50</accession>
    <name>B7GD50_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chitinase chitin binding glycoside hydrolase family 1</fullName>
            <ecNumber evidence="14">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_50155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="14"/>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184991.1">
        <property type="nucleotide sequence ID" value="XM_002184955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD50"/>
    <dbReference type="STRING" id="556484.B7GD50"/>
    <dbReference type="PaxDb" id="2850-Phatr50155"/>
    <dbReference type="GeneID" id="7198854"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50155"/>
    <dbReference type="eggNOG" id="ENOG502RZQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519250_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD50"/>
    <dbReference type="OMA" id="CNIATPP"/>
    <dbReference type="OrthoDB" id="43722at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856106" evidence="11">
        <location>
            <begin position="26"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="95"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="525" mass="55275" checksum="E65753BBCF1F3077" modified="2009-02-10" version="1">MTIAIYQSIFSLILVGGFLSSTSLAATCSGGTIGDGICVDNTLCCSRFGWCGLGPDWCDEGNTASPPTPAAAPTITGSPPSPVPPTVPVILNDDSRMIAYMGNWHTCPTAAQLTQYTHVVLAFAVSYTWAPGKNQCDTQCNIATPPVCNNAPNDSLISDLHAAGKKIILSFGGAGMGGSWSSSQDDCWDYCFGKEEKVVSRLTEIIDDMNLDGIDIDYEYFYEDNQNGSGFTKGAQAQKFLTEITVGLRNSLPAGSIVTHAPMDSDLVPGKAFYKLLKDISGTLDFIMPQYYNGLVRPALDGVDGSGFGQETSISLYSQLANDYFGGDATKIVFGFCIKDCSGTNSNANAVQAAAVMSELSSVYDCNGGAFFWVVNDDTNGSWSSQVNQVVQLNAGCAASNSPSTVAPSSFVATTHPSAAPTKQPNQSPMAAPTKGTPNPSFAPTSKPSLRATTAPSNADGFEETKCCPPDFTGLRALDNCSKFFHCVGGAVVGPETSCGSGLLFDQKFMYCNWSDQVACVPNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD67</accession>
    <name>B7GD67_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185000.1">
        <property type="nucleotide sequence ID" value="XM_002184964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD67"/>
    <dbReference type="PaxDb" id="2850-Phatr50171"/>
    <dbReference type="GeneID" id="7198948"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50171"/>
    <dbReference type="HOGENOM" id="CLU_375302_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD67"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="740" mass="80245" checksum="10F4C5577394C0E9" modified="2009-02-10" version="1">MKDSASSESSKATIGVTLSNAIPSDASSRARSILGSMKEHRETFSRVVHHGHSSHGDDFRMASAVSLSPSNPFSSKSEDTMLTIAQQLNDSLNDRRQRLSRVSGIDVGNKTTTVDSAAGENVRTAPTSPVSQRSGHTVATEESTVATGTSSPGQSSFDPSYATTQPPDSPTQQQQRLGIVQSREPVAIASTAQLPSNEEVENPDILENADVHEKHGGSDSKAACESVSTVDVSFGPETQFRHVRSSKSFGDSALESRNASVPRSIITTSSSFGHFSFSSSPYVTDKTTSKQETDLRFSPLPRLCHILPASIPPVPLEDPLWAAVDDCASPLLRGSNRTNDNLDNTAGQTGNIQGSYATLYPNQIEADACIDEIHSASQRLQYASDDDNHPAQGEAEYSQQSAARTLRRPHELEKNVCDSTSPDYRELLNISVVEEYADRRRLLKALRTDDRRLKQAPTELTDASNAEEATSNSDAHGIGGSSEEDDPFSSEDSSLDCTTDSDTSGWVSSSDSINSALSTRVGKRSVDFSSREGKCRAELKADCASANVSTSLLLSSSNDTAQKVPRSERLICQGGLFWIALRSDWDQSHPDRIQTLPKPSSADVLHLSSDLRCGTQGSMYDLCLKSGFNTNAKTWEPVDYGTQGSIYDLCLKSGFSTNAKATEPAEIREEQFNEARGGLWYLASRSPLSRDRRLEPYSVKGKPRTRPHGAIKIQSDYKTDRECGAKGTLHLCMTLQLQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDM4</accession>
    <name>B7GDM4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185155.1">
        <property type="nucleotide sequence ID" value="XM_002185119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDM4"/>
    <dbReference type="PaxDb" id="2850-Phatr50302"/>
    <dbReference type="GeneID" id="7199052"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50302"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092162_2_0_1"/>
    <dbReference type="InParanoid" id="B7GDM4"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="28506" checksum="0BE9637B2804D873" modified="2009-02-10" version="1">MLSLTARGRVSRLAAKHLLPCVLFSSCPSAVFDPDPSLLNATKAPLDFDNSASVYREFITEAQEQTLIEELQAKLKRSRYQKGHWDAAIVDYRETEVIDEASTLSVEFRGVLERVRAQILARHLMHKHQSVAPELLWLPCHCIDLKKEGELNAHVDSVRFSGDIVAGLSLMSSSIMRLREEKQELVSSQRKQTKDEPYVDLFLQERSLYVLEGYSRYRYTHELLPSGSTFGDKVVHRENRLSIIFRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDY0</accession>
    <name>B7GDY0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_31133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185287.1">
        <property type="nucleotide sequence ID" value="XM_002185251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDY0"/>
    <dbReference type="SMR" id="B7GDY0"/>
    <dbReference type="FunCoup" id="B7GDY0">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDY0"/>
    <dbReference type="PaxDb" id="2850-Phatr31133"/>
    <dbReference type="GeneID" id="7199151"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31133"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDY0"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12907" checksum="8134D5AB92BF5701" modified="2009-02-10" version="1">MEVGKLIAVIGDEDTVTGFLLAGVGHRTADGSNFLIVKQDTKLQQVEEAFQNFSVRDDVGIILINQHVANDIRHILKDYHETIPTVLEIPSKEHPYDPEQDYIMQRVNMFLGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE70</accession>
    <name>B7GE70_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thymus-specific serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185433.1">
        <property type="nucleotide sequence ID" value="XM_002185397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE70"/>
    <dbReference type="ESTHER" id="phatc-b7ge70">
        <property type="family name" value="Prolylcarboxypeptidase"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr50463"/>
    <dbReference type="GeneID" id="7199313"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50463"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020959_3_1_1"/>
    <dbReference type="InParanoid" id="B7GE70"/>
    <dbReference type="OMA" id="NDYIDSQ"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856077" description="Thymus-specific serine protease" evidence="6">
        <location>
            <begin position="26"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59601" checksum="77201EF3CD859E02" modified="2009-02-10" version="1">MPAMLFHRLLLSYLLLLGVDVHGLGDVRLRDVLNARRTNAKVTDESSLGADVPEFVGDVQTRYVNQQLNHFDASDTRSFAQRFFYSDRYARAREENRNTYAFLCVGGEGPALDESVLVDSVHCTGDMLELAHILFEDGHKVHLYALEHRYYGESYPVFREGGCSKNRTTSPVTNQHLVYLSSTQALADLAHFVNSRSLDGGTNIKWVTFGGSYPGMMAAWARSKYPHLIHAAVSSSAPVQAVLDFSAYNNHVSKVLASANVGGSSECLAVFQAAHGEVTRMVHDATQHAGLADMFGLCNATSLLEDRNKELFLGDGLVDLHTQGNNPSCDRDLCNIGKICRTLLNDAKSFKPVTALANLAQRQRDRGACINIDWTGTLDYISDPVRGVEGGLRSWLWQTCTEFGFYQTCNMHSTCPYGRGFHRVDQDLEMCRVAFDKSGVQVATAVRSSMEAYGGWKMEASRILSVNGDIDPWSELAIHDVSNPQLPTYQVPGASHHFWTHKVLDSDGLEIQKAREFIYDTVTAWLETGSPNEPTTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEB4</accession>
    <name>B7GEB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_50508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185457.1">
        <property type="nucleotide sequence ID" value="XM_002185421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEB4"/>
    <dbReference type="PaxDb" id="2850-Phatr50508"/>
    <dbReference type="GeneID" id="7199287"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50508"/>
    <dbReference type="HOGENOM" id="CLU_726609_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEB4"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="3">
        <location>
            <begin position="224"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42895" checksum="71D99D07B4F9A767" modified="2009-02-10" version="1">MMAAVSTTDWRIRLFGPQIQLNQKMEISADQINDIEAPHALPTVSVSTIEAFDSSKYDYIAVFLGADYCPHCKAFAPTVHQSTSALEKKRCKVVFVSNDRTLEAFHASCQKNRTLDVMPYDLEKTQTMRDLFGLQTIPALMILRNSGFDQENPTVLSNGRQALVADPQGAQFPWSSDSPSSTITGTKKASSISAWERLWIHGKYGNWWELGHHSNPEKPDQIYMDEHAVRIRAGILNTVSWVAIINIFFWKESLMLYILYPIVAWEFILSSFTGLTPLAPIGTLSTLLAIVLQPEPHWKPAKPKRFAWMIGLSLATTCLIIFLFRKELGPDLYRPLMGAVAFTCNAATWLESSAGFCIGCYIYNTFLVPMYNLEECSECKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEJ2</accession>
    <name>B7GEJ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TAZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_41559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185494.1">
        <property type="nucleotide sequence ID" value="XM_002185458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr41559"/>
    <dbReference type="GeneID" id="7199398"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41559"/>
    <dbReference type="eggNOG" id="ENOG502S1FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278058_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEJ2"/>
    <dbReference type="OrthoDB" id="200182at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="941"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1148" mass="124372" checksum="1027516CD809013B" modified="2009-02-10" version="1" fragment="single">VGRLALTLRRRLAGISAAEPLSSVTTVVFGLAKTAQGDARSFLFWAGKAAEIVKKAPCDTENEETTVGAKTERIAQHRTDRRQRHVLMVTMAIPTNVCLLLSEIFRFLMMEMEEHDLAQQKDPGKVSSCSDSKGEGHALEVQLVYVSSAVGFRVSWRSASSLLSSRGRGYPILSDGCGARSQSTNEAVSRTTDSSNHTLLQNSNLSQQPPLPLLLPATDSLRHPANPLYSRNRSHDTNSAIGVSDPATHTSRAMSSHTSLQYSSSGGIANISTTTDPPHKRLKLDHAMSHTSLGNPSLSYHDFAAHYDSRSTLHTSSTMDLGVLRKEDSLGMMRKDGDDEDDENDQNDPISSTAVRQATVQPTALPNESAKPTHPTTANVATTNSVSSSDSLRDLSAHRPQHPQNTTRLPVSSSTTTVTSGSNSPLSAGPVSAQAPPSPLLPLKATKMSHLRQKYMQELEYMLCEFQKLERQLLGAKATTAESAGSRERREKLHSFITHLSDTIQNIQTGCQLESEGKSTVGEASKQDIAQEAALADLTCEKGEEENVQKLEEHILANLLPVKVRLKKQLAAQQGAKHNPAGMPVAQRGLVAPSEGGKGTFAAAAEERRKQLADAAAAAQGFDHTHVPAEPVHPDQTQFGKPLQGNGSSLTRNLHGSTLGSAIKVGTDKSKILFAGLAIGSSQVKSSVNAASSVHQLVIKDPALLELARQQSASKQQEDLPPQTQQEDSPTQSKPNSLLPPSSSEPNDSPEDTNRKAISLKVSPAVASAAALAASEQPDAVLSKAPPSRLDDVDATYPDMPSAALTDEERRTLRRLKRRKKRRKRKAEATPVTAAATAAPVINRHHKPTTKKRGPRTVEYMCALCNEVYNSTCDYNPWWALAQHDCPKCRKNQIPRVDISAPANTIEYHPALLAHADENGGSTPTPPAAIVKPVTTVSAPVTSVPKCGNDSDSFGSDLSDDDLDGLLSDTDSEGSGEIGMERIDALSPAEQAENEYFGVEYKGPKLKDSEAARLLILMGHASTCPCKHQSIKHRETCRNTKWMMLHVRDCPGTTSSFDVCPFPWCRKVKHLLYHLVSCRDAKHCEICSPTKLNQNMILLKGLNQHRFMQYRERLIGRGKALTKVSNSAPKNTPAQAQHKTFIDVSQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4K0</accession>
    <name>B7S4K0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TRD4</name>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999299">
        <property type="protein sequence ID" value="EEC42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176490.1">
        <property type="nucleotide sequence ID" value="XM_002176454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4K0"/>
    <dbReference type="SMR" id="B7S4K0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1870"/>
    <dbReference type="GeneID" id="7204971"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1870"/>
    <dbReference type="eggNOG" id="ENOG502STBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070458_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4K0"/>
    <dbReference type="OrthoDB" id="46933at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="30589" checksum="17F6E3120F78643A" modified="2009-02-10" version="1">MVAQNVLIGTAVALVVIIAVVIPVAILVPKNNDSNRSGISALTEALPGGTNFPTILPSSFPSLRPSDLEPSASPSIGPSAAPSDFPSGSPSAQPSPSPTSAPTLPPVDPNFEFNLMMHWEREFFWQEEYTERTWCMECMKCNELSGADGNSGCRDSNSNSFDCDNKDQLWLQDCGGRSKGTAVFTIVRHDSSDQIRVQGSDLCLTLVRPRFINLQPCDEADILQRFRGFDRNQPFDLRPVLNDDGCLTQSHHPRAGEVIFNGGCELAYFWNTALWDAIPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0C2</accession>
    <name>RK11_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein uL11c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">50S ribosomal protein L11, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl11</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874397.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0C2"/>
    <dbReference type="SMR" id="A0T0C2"/>
    <dbReference type="STRING" id="556484.A0T0C2"/>
    <dbReference type="GeneID" id="4524712"/>
    <dbReference type="InParanoid" id="A0T0C2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000001">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000276325" description="Large ribosomal subunit protein uL11c">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="141" mass="14828" checksum="2F68F743201AEDDA" modified="2007-01-09" version="1">MAKKITALIKLALPASKATPAPPVGPALGQHGVNIAAFCKEYNARTNDKAGLIIPVEISVYEDRSYTFVLKTPPASVLLANAAKIKKGSSNPNTVSVGSITKTQLEEIANIKLPDLNTTKISSAMKIVEGTARNMGISILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0E4</accession>
    <name>A0T0E4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-sulfur cluster formation ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sufB</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="4"/>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0E4"/>
    <dbReference type="FunCoup" id="A0T0E4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="556484.A0T0E4"/>
    <dbReference type="InParanoid" id="A0T0E4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008773">
        <property type="entry name" value="PRK11814.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="215"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABK20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="486" mass="54457" checksum="040B1755E324069C" modified="2007-01-09" version="1">MVNKSNKVLNKNITNLVNQTYQYGFSTTIEKDIIEKGLNEKTIHLISQKKKETKFLLNFRLKAYKKWKQMPEPEWAYIKFPQIDYQDVIYYSAPKSQKKLKDLSEVDPELLKTFEKLGISLTEQKRLANVAVDVVFDSVSIGTTFKEELNKSGVIFSSISEAVTEYPELIEKYLGSVVPIGDNYFAALNSAVFTDGSFCYIPEDTICPLDLSTYFRINDEKSGQFERTLIISEKNSQVNYLEGCTAPQYDSNQLHAAVVELIALENANIKYSTVQNWYAGNEFGKGGVYNFVTKRGLCAGSSSKISWTQVETGSSITWKYPSCVLIGDNSQGEFYSVALTNNYQQADTGTKMMHIGRNTRSRIISKGISAGKSKNSYRGLVNVTSKALGARNYSQCDSLLIGDLSNANTFPFISVQNSTTKIEHEASTSKIGEEQIFYFLQRGICLEKAVELMISGFCREIFTELPLEFAAEADKLLTLKLEGSVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0F6</accession>
    <name>RK20_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein bL20c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">50S ribosomal protein L20, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl20</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874431.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0F6"/>
    <dbReference type="SMR" id="A0T0F6"/>
    <dbReference type="STRING" id="556484.A0T0F6"/>
    <dbReference type="GeneID" id="4524605"/>
    <dbReference type="InParanoid" id="A0T0F6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.20:FF:000001">
        <property type="entry name" value="50S ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_bL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049946">
        <property type="entry name" value="RIBOSOMAL_L20_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000276436" description="Large ribosomal subunit protein bL20c">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="112" mass="13029" checksum="97A9A19741C5E148" modified="2007-01-09" version="1">MVRVKRGNVARKRRKKILALASGYRGAHSVLFRVANQQVMKALRYSYVGRKQKKRIFRRIWISRINAASRLNGISYSQLIHRFKKSNIDLNRKMLSQIAVLDTVAFKTLLNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0M7</accession>
    <name>PSAB_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem I P700 chlorophyll a apoprotein A2</fullName>
            <ecNumber evidence="1">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PSI-B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PsaB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psaB</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>reduced [plastocyanin] + hnu + oxidized [2Fe-2S]-[ferredoxin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="1">P700 is a chlorophyll a/chlorophyll a' dimer, A0 is one or more chlorophyll a, A1 is one or both phylloquinones and FX is a shared 4Fe-4S iron-sulfur center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The eukaryotic PSI reaction center is composed of at least 11 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast thylakoid membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PsaA/PsaB family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="1"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874358.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0M7"/>
    <dbReference type="SMR" id="A0T0M7"/>
    <dbReference type="STRING" id="556484.A0T0M7"/>
    <dbReference type="GeneID" id="4524635"/>
    <dbReference type="InParanoid" id="A0T0M7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1130.10:FF:000001">
        <property type="entry name" value="Photosystem I P700 chlorophyll a apoprotein A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1130.10">
        <property type="entry name" value="Photosystem I PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00482">
        <property type="entry name" value="PSI_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001280">
        <property type="entry name" value="PSI_PsaA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020586">
        <property type="entry name" value="PSI_PsaA/B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036408">
        <property type="entry name" value="PSI_PsaA/B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006244">
        <property type="entry name" value="PSI_PsaB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01336">
        <property type="entry name" value="psaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN, OMPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128:SF19">
        <property type="entry name" value="PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00223">
        <property type="entry name" value="PsaA_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002905">
        <property type="entry name" value="PSI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00257">
        <property type="entry name" value="PHOTSYSPSAAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81558">
        <property type="entry name" value="Photosystem I subunits PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00419">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0148">Chlorophyll</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0157">Chromophore</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0603">Photosystem I</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000277142" description="Photosystem I P700 chlorophyll a apoprotein A2">
        <location>
            <begin position="1"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=I" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=II" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=III" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=IV" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=V" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VI" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VII" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VIII" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=IX" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=X" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=XI" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B3</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>phylloquinone</name>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <label>B</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00482"/>
        </source>
    </evidence>
    <sequence length="733" mass="81847" checksum="DF77965FF12A2BBC" modified="2007-01-09" version="1">MATKFPKFSQALAQDPATRRIWYGIATAHDLEAHDGMTEENLYQKIFASHFGHLAVIFLWTAGNLFHVAWQGNFEKWVSNPLKVKPIAHAIWDPHFGESAIKAFSKGNTYPVNIAFSGVYQWWYTIGFRTNQELYLGSVGLLILASVLLFAGWLHLQPKFRPSLAWFKNNESRLNHHLSGLLGVSSLAWTGHIVHVAIPASRGVHVGWENFLTTPPHPAGLTPFYSGDWTVYAANPDSANHVYGTAEGAGTAILTFLGGFHPQTQSLWLSDIAHHQLAIAVVFIVAGHMYRTNFGIGHNMKEILDAHRPPGGRLGAGHTGLFETITNSLHMQLGLALACLGVATSLTAQHMYAITPYAFLSKDFTTEAALYTHHQYIAGFLMVGAFAHGAIFFVRDYDPELNKNNVLARMLEHKEAIISHLSWASLFLGFHTLGLYIHNDTVVAFGQPEKQILFEPLFAEYIQAASGKAVYEFNTLLSSSTSPATVAGNQIWLPGWLEAINNNKNDLFLKIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAMFWMLNTIGWVTFYWHWKHMTIWGGNPGQFDESSNYIMGWLRDYLWLNSSPLINGYNPFGMNNLSVWAWMFLFGHLIWATGFMFLISWRGYWQELIETLVWAHERTPLANLVRWRDKPVALSIVQARLVGLVHFTVGYVLTYAAFVIASTAGKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3E9</accession>
    <name>B5Y3E9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_13244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185832.1">
        <property type="nucleotide sequence ID" value="XM_002185796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3E9"/>
    <dbReference type="STRING" id="556484.B5Y3E9"/>
    <dbReference type="PaxDb" id="2850-Phatr13244"/>
    <dbReference type="GeneID" id="7204592"/>
    <dbReference type="KEGG" id="pti:PHATR_13244"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3E9"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="6">
        <location>
            <begin position="62"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="27906" checksum="F9AEDE7CDDD89DC4" modified="2008-11-25" version="1" fragment="single">PTFVRLAWHSSGTYDQITRTGGSGEGTIRFKEELAHGGNAGLADTAVVWLEPLYKKYKKDGLSYADLYTLSGVASIKQMNGPTIPWGSGRVDAMSPIVVTPDGRLPNADVGPKGADKSDAAHLRDVFYRMGFNDQEIVCLSGAHALGRCHTTASGYDGPWTPTPTTFNNAYYTLLSNLNWVPKEWDGPYQYVDAPTGRLMMLPTDLVLLQDKSFAKYVKEYASNPKKFDYDFTVAFQKLEELGTNNLTPCDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3S3</accession>
    <name>B5Y3S3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_28219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185707.1">
        <property type="nucleotide sequence ID" value="XM_002185671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3S3"/>
    <dbReference type="FunCoup" id="B5Y3S3">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3S3"/>
    <dbReference type="PaxDb" id="2850-Phatr28219"/>
    <dbReference type="GeneID" id="7204540"/>
    <dbReference type="KEGG" id="pti:PHATR_28219"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_6_1_1"/>
    <dbReference type="InParanoid" id="B5Y3S3"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="221"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACI65177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="447" mass="49220" checksum="F26D8A08CF29A3BD" modified="2008-11-25" version="1">MSSGECQTGNKGDYDEEEKEDAPPPLDEGDIVLLKSYGLGPYSTKIKDVEKEIKKHQQTVKDLIGIKESDTGLSPPSMWDLNGDKQMMSEEAPLQVARCTKIITGDSDASNEGASSAVSTSTKYVINVKQIAKFVVGLGETVAPTDIEEGMRVGVDRSKYSIQIPLPPKIDPTVSLMTVEDKPDVTYDDVGGAKDAMEKLREVLELPLLHPERFVTLGIDPPKGVLLYGPPGTGKTLSARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFTMARSKRACIIFFDEIDAIGGARTGSDENGSDNEVQRTMLQIVTELDGFDARGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRGHILRIHSKRMNCDRDIRFELIARLCPNTTGAELHSVCTEAGMFAIRARRKNVSEKDFLESVNKVVKGYKKFSSTPKYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4H8</accession>
    <name>B5Y4H8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186012.1">
        <property type="nucleotide sequence ID" value="XM_002185976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4H8"/>
    <dbReference type="PaxDb" id="2850-Phatr33153"/>
    <dbReference type="GeneID" id="7204272"/>
    <dbReference type="KEGG" id="pti:PHATR_33153"/>
    <dbReference type="eggNOG" id="ENOG502SUSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609017_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4H8"/>
    <dbReference type="OrthoDB" id="48529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841124" description="Fucosyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49880" checksum="98216BC44D815C7A" modified="2008-11-25" version="1">MSTGTKNSFFATTVCVALFCFVRALTSLGTVQNLQVFDTELKDIAESVHSLSVHGTGADSNNSLPKAKPDDVYVLESKTKAAVRESSLRESTLVTNAGIEFRKPIWSNASSFDNGAPSILVQLNGELANYLGFIAKAFGLVWWLEREYGVNPTIVLRHQQHPKWVGAHADVTRCFPYLRDFNFGAGNTRDISKELSVLSQSHQQSNGTAERVVDIRSEVPYDKTIQSFLSLYAKSHIHIGGEKSRINIPFLTTKQMSCRDLIVDKYYDDIRRIYRFDKSCCVDVPDPDESVFERSGLRKQPGYEELAPEQVANELFAHLNPGDKVAIISRYPNDFRTQMIVGAFEKRKIRARVVEPRSGVADFCFLMHTQKEMVGTAWSTYFLWAGLLGNATSVRPYTAIVPGRNSKIDSHNFTHPDLKSRFRFEHYISNFTAGDLRKPKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4P4</accession>
    <name>B5Y4P4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_5175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186328.1">
        <property type="nucleotide sequence ID" value="XM_002186292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4P4"/>
    <dbReference type="PaxDb" id="2850-Phatr5175"/>
    <dbReference type="GeneID" id="7204303"/>
    <dbReference type="KEGG" id="pti:PHATR_5175"/>
    <dbReference type="eggNOG" id="KOG0763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="InParanoid" id="B5Y4P4"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF15">
        <property type="entry name" value="MITOCHONDRIAL ARGININE TRANSPORTER BAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28258" checksum="49C2BADA6810CC92" modified="2008-11-25" version="1" fragment="single">RDIFSATLGSICCCYVGQPFDTVKVRMQTNPTVYSGVISSVTNILKNEGVAAFWKGAVPTAMGMALENAMAFGVNEALKRSFPDDLSLDNNAMPSLTKPFAMGAMTGCCSALVLLPSEIVKAKLQVVVGKNVSSGEIIKQIVSKQGVRGIFAGLDAQLARDASFYAIFFGGYEVSCYLFRTHVPSMPDELNYFISGGLAGMFGWTIAMPFDVPKTNVQARYDTKVVGSYAPELIRIAQERGVVGLYSGLGPTLVRAFPANAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Q0</accession>
    <name>B5Y4Q0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_43899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186049.1">
        <property type="nucleotide sequence ID" value="XM_002186013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Q0"/>
    <dbReference type="STRING" id="556484.B5Y4Q0"/>
    <dbReference type="PaxDb" id="2850-Phatr43899"/>
    <dbReference type="GeneID" id="7204307"/>
    <dbReference type="KEGG" id="pti:PHATR_43899"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4Q0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="113"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="39265" checksum="8C86A0386E758D92" modified="2008-11-25" version="1">MHYAVAHDKILRAVKGTTSQAGEELEDTQYQRVSNSFARRQMSQQQIEELEQLANTSNVVLKTHRRNYQSFVTDAILAEEVNFVETKLSTWMASMEKRANRAQNKKNAQATHTGMECCCCFDEVAVEDMVSCRDEGHLFCVDCLKSFAETQIFGMGNLGIDKETKKRSLELKCFHSDGCASGFGRSGLEKALPKRSLEKYDEVQFILSVEVAGLDDIVSCPNCGYQAALQPSQRVFKCPVIDCLYESCRECGEAAHIPLRCDENKKTDEKETKGRLAVEEAISEGKKPDQVLAALLSEVALCRHIDCKGCPLYTNGEEDDARAMRKAGLKAANEVRKDDVNIDVENILKAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4R4</accession>
    <name>B5Y4R4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_43913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Preautophagosomal structure membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186339.1">
        <property type="nucleotide sequence ID" value="XM_002186303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4R4"/>
    <dbReference type="STRING" id="556484.B5Y4R4"/>
    <dbReference type="PaxDb" id="2850-Phatr43913"/>
    <dbReference type="GeneID" id="7204356"/>
    <dbReference type="KEGG" id="pti:PHATR_43913"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051894_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4R4"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="9">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="9">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="8">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="7">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACI65809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="330" mass="37155" checksum="F62D99D9D1CBD213" modified="2008-11-25" version="1">MVEDEGRRTQAANWHGSIPVVLTLSSRSLSSPTMPPPIHVLVPRNTYLHVGLQTAVNRLHRFAPTTLSFVSGMIQKEPDPGASTFAEDDENDQADTNTASQTPSDSAIGRAADERYPVCWFEDEDTQFALRWHLFAGVLYDTKRAKVPSASSLPWKIRLHFTAYPTSQILPLEADRVLVQIQNFYKNSVKQALCLQYGNSKAAMNLTKESHFRLWDAVLTTTYPLHRQVNDDLPTQTQETISQIPVRVLVNAARPPIQRACRDSSVQLGALLSQWLPDYFETVNDTAQAKDQVVQWRVGGIQPGLELPVFQLWKALCHPDYFLYVIVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5A9</accession>
    <name>B5Y5A9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATR_44086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186154.1">
        <property type="nucleotide sequence ID" value="XM_002186118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5A9"/>
    <dbReference type="STRING" id="556484.B5Y5A9"/>
    <dbReference type="PaxDb" id="2850-Phatr44086"/>
    <dbReference type="GeneID" id="7204025"/>
    <dbReference type="KEGG" id="pti:PHATR_44086"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5A9"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="511"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="322"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACI65624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="794" mass="89326" checksum="B343CBE2D4800DD6" modified="2008-11-25" version="1">MTDAILPSLEAAVEDWNGFNWNERLAEVDIFLQQTKEVKEQSLQARKNLAEITKQLKRSVKSVETTTFDLKKEANPESVASSIKSMESLTKECRVTVKSYQEEIDNLTRRCKTSESSYVSLCQALSEQSEPAAILASALQHIHAQQAQMTQLLSTVEHVNQELQSQETMNVSYRKEIASLQKSKSNSSGNAGVGKADREELVQLRREVAEYEIEFRSLKNQDITIRRLEARIAELQTVGEEHLKEELEKHKEELQESEGRKVAEALEREAAMERKVQTLELQLQAERAGREATQGALLDADEGVSQREAAWEAQRRILVDDAERVRESLQTATRERDELRLKMAAVSENTTPEPSPPSGGLSVSDLILERKAYEAEVAELSETANMLREELRTKELQVMDEKRISQVKLSNLERQVATLSFDLSTAQSQLHSAPSQALVDNMKRELRILKRLEYNADDVDTERDPEIAGGNAGDEDDKDLESVLVAKLRRAESDLVTERVTRTSLIEDIETLKKSMLDAEKTNNALEKLVASLERDLERAIATPSAATSRKQSEHVLVEENPATLEHILDPNAAPPLPPPPPPSARSQSESESQQDDHSVATIVMAQRDRLRARCEALEAERDSFKRELQGQVQASEHLKTDNTKLYEKVRYLQNYNKPPSSGHGTAYSRSISAGDRDLDLEALEQRYEASVDPFRQFSKAERQRKLNEMSPMERTVFIVAKTFLATKEMRTALFFYVVAMHLLVFITTYHWSQAAGCIGPNKDYLSHLPPTMPKPVTKEEAPVAGAAAIPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5W6</accession>
    <name>B5Y5W6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_33088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185983.1">
        <property type="nucleotide sequence ID" value="XM_002185947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5W6"/>
    <dbReference type="PaxDb" id="2850-Phatr33088"/>
    <dbReference type="GeneID" id="7204154"/>
    <dbReference type="KEGG" id="pti:PHATR_33088"/>
    <dbReference type="eggNOG" id="ENOG502RC0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1252792_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5W6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841193" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23554" checksum="A9E6BBE5A1629F7B" modified="2008-11-25" version="1">MAMIKLAVLLLLLLPYTSAGSTAFRYNDDLSCDRGLSASSLSVACDGGDSCSLGSTAKISGSLSLSSELPTSAKLYGKICFLYVICYDFEEENVDLCDRAGLTAGSGQSCADTGDYSIDTSLKVPGKPKDLMSGWSLKVTAYLEDNNNNEIGTTKCTFSVAAVQGYTTTYTGFAALGMASLVLALYVRKKRRVGRINLLDEEDKAAPSGNFEMMTEKKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNT1</accession>
    <name>B7FNT1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_9444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177093.1">
        <property type="nucleotide sequence ID" value="XM_002177057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNT1"/>
    <dbReference type="PaxDb" id="2850-Phatr9444"/>
    <dbReference type="GeneID" id="7196270"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9444"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_3_1_1"/>
    <dbReference type="InParanoid" id="B7FNT1"/>
    <dbReference type="OrthoDB" id="10035043at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="297" mass="32737" checksum="A8F3E78A86D4230F" modified="2009-02-10" version="1" fragment="single">MGLQLSYLTWGYMQELIMTTTFTPTPRVPSGKFPSAAFCVFSNRFLAVIVALLAVRYKHGAFFANNTAPLWAFTPCALSNTLSSWSQYASLKYVSFPVQTVFKSSKIIPVMVMGKVLKGTSYPMNQYFEALLITIGVAIFSIMSKSSDKAEASTEILGLIFLLIYICFDSFTSQWQDKVYTQYGRVNVDPYQMMLGVNVSAICITTAGLIVTGDIPVVFEFLVANPEAFRYNIITAITSASGQLCIFYTIKEFGPIVFTIIMTTRQMLSICISAMLFGHQISLKAASGAAVVFGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNW0</accession>
    <name>B7FNW0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_9283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177106.1">
        <property type="nucleotide sequence ID" value="XM_002177070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNW0"/>
    <dbReference type="FunCoup" id="B7FNW0">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FNW0"/>
    <dbReference type="PaxDb" id="2850-Phatr9283"/>
    <dbReference type="GeneID" id="7195967"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9283"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="InParanoid" id="B7FNW0"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="229"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="623" mass="69780" checksum="F0D2B8ED597256C0" modified="2009-02-10" version="1" fragment="single">QISVYYATQTGTSESFARQLEREGPSHGFYVHVVDLEDIGVEDVVDEIQKDQESGISRAVFLGATYGEGEAPDNATQFVAALAKKAATEMLFQNLKVEELSVPDRCLVGLDFCVFGLGNKQYDHYNATGKFLDHALERVGGNRILGLGMGDDDGDLEGDFETWKDKKLWPTMERLYVFDKEALGKRKREAALRVELPDCQYEVHYIDNGDSDFKPMPFDQVHGSSRHYFTAVDCPVTKVQELRSSEEPGSTVHVEIDISSARGLTYATADNLGVLPVNAAETVEAVARALCYDLNAVFYVKAAPNHEWHGAPFPMPLSIRECLTRYCDLTSAPRRSDLKLLASYAKDPMDQKALLRMSSKEGRTEYKEKVLASFVGIVDLLKLCPSIEIPLAHFLAVCPLLQTRFFTISSSASVYPNSIHLTVAVTDALRSDGTMFKGVCSNYLASRVPGKDVIRVYSRPSTFRLPQDSSKPILLIGPGTGVAPMRALLQERAYQREHLNQSVGQNILYFGCKKRSYDFLYQEEMERFHCEKIIDKLYLAFSRDGDQKIYVQHLLEQNSEETWRLIHFEGAYVFVCGGVKMGHDVAETLKKIAVSQGSMSLEGAKSYMTNLAKESRYVQELWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNW8</accession>
    <name>B7FNW8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176608.1">
        <property type="nucleotide sequence ID" value="XM_002176572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNW8"/>
    <dbReference type="PaxDb" id="2850-Phatr42606"/>
    <dbReference type="GeneID" id="7196288"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42606"/>
    <dbReference type="eggNOG" id="ENOG502SI70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030622_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNW8"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855125" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="290"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="630" mass="71146" checksum="1F0252CD907F2595" modified="2009-02-10" version="1">MKSTTKLCFAILGALLIPPVEAAASEGDEPTSCRLWLAPSAVSTDRKPKFGLFAGATYSMDDIIPLSELAIPLSDFMEYPNRARSQYDSDILDFVQSFVWTSEYAGGRWEGNYSSTVFVPGIGILSNYHTGHSNVDWLQGAMRSHSRALPHPSRGAITPYYNMTLRAIRTIPAGMELFANFGEQWDGSFGDDAFQDKLTRWEYQDADKLLDKIVDFMDQFGDQMSETLKDDVLDFMLEKVLGTATGKRAKIIKSLIPAHPQKLQRVLDAGGTFVYRNRDLVKSPRWLEDNGICVDKMRGDTSTIPDAGRGAFATRKIAKDELIVPVPMIPVGNKALMDMYEFVENHDEEGRPTGLTYNFEKYRGQQLLVNYCFGHPESSLLLMPVGPLATLINHGSLRDKANAYLTWSKHTSVWNDHSLHDLHVHEVMNQEYPNIVMEIYAIRDIEEGEEIFIDYGAAWEQAWVEYKENWQASTLDGKWPLKAEDMNSIFLTKPFPINLQQDSSPYPDGVATACYIYIGEQTDGEAHENEDGLSIFPWIGPKSFEDYVGQVLTVCDLRGREESVEHGFVYMVRARLPGQDEVVEVKGVPHVAVTLVDQPYQADHHRPGAFRHPIAVEDQRWPQAWRDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPI6</accession>
    <name>B7FPI6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176721.1">
        <property type="nucleotide sequence ID" value="XM_002176685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPI6"/>
    <dbReference type="PaxDb" id="2850-Phatr42779"/>
    <dbReference type="GeneID" id="7196401"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42779"/>
    <dbReference type="eggNOG" id="ENOG502SWE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531546_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPI6"/>
    <dbReference type="OrthoDB" id="48364at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="274"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="521" mass="58280" checksum="DBFAB81323EB5ABC" modified="2009-02-10" version="1">MCISVEKPMVADGNRSSRSSFFETPILRLRYSVVGPALTIDAQVLLALVLIAAYLSNCLQEERVSFLNNFWTIRTILQQESLRAVIFVFSMFAFGRKWFGSLLGAQKLAQTGSSALKSVASNGTIVRIRSSMSMSVISDRLMSMNGKSTSHRASLSLSDKTCFAQLKDIEKLSVKDMGSIFRYAIQYNIWTDAQLKAFLSEIRVQALSVVTAIDHALPPLHRASMVQEPNAQSSSPRNFGDMDVLLFSAAVRVFAEWRLLRLTPAGYRNYALGMALTRRDLVQNIGKIEAAVHELLESQTSHNGVNSIRPTIWQLLDYEVQRGVHPKLPYLVEKSGASGILWIMRQLSFQVNSFEYISKVPTAFPSFKIAVRSAYDRVYGDYHGFFLKQIFWNSFKSAPEASVILKFMEETEEIMSRDLSPSNSSEKATVLTRDAVCDNIQSPQERNHFIGMFLEVQQFLKQCHGGHPKVRPPAVDTSLHGPEHIGQKGGDLTAFLLEMHPLISGLDGLIGHFNMKDPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPL4</accession>
    <name>B7FPL4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_31882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176734.1">
        <property type="nucleotide sequence ID" value="XM_002176698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPL4"/>
    <dbReference type="STRING" id="556484.B7FPL4"/>
    <dbReference type="PaxDb" id="2850-Phatr8691"/>
    <dbReference type="GeneID" id="7196165"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31882"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="B7FPL4"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF22">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="29952" checksum="BC3F30B7E1609898" modified="2009-02-10" version="1">MVYSASLVVASTKSELPYHLNSAIMKVCQEALVQRGTFTIALSGGSLPSFLSSVKDVFEAAGNDPKFESWHIILADERCVPKSHPDSNMGALENDFLNQVSVPSDQVHAINTRKLEESTDAVASDYQEQIEEVLSISGGQLDLAVLGFGPDGHTCSLFPNHVLLTEQNKMVAAIEDSPKPPPHRITLTLPVLNKHTRHVIFCGAGRSKSAVVRDVFSDISPADASYSVQHGNLYKVTLSSPAPYPCAMVRPDSEQTENSLMWIVDADAMESATEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPS3</accession>
    <name>B7FPS3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176761.1">
        <property type="nucleotide sequence ID" value="XM_002176725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPS3"/>
    <dbReference type="SMR" id="B7FPS3"/>
    <dbReference type="STRING" id="556484.B7FPS3"/>
    <dbReference type="PaxDb" id="2850-Phatr42848"/>
    <dbReference type="GeneID" id="7196441"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42848"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728556_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPS3"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="380" mass="42946" checksum="70BCC3AD460C463A" modified="2009-02-10" version="1">MLSFRATFSGKTFTAKRLAVCDAIEHIQTRLLSDVKKPQGFRPRRRPARGYRPVKPVTKKARDLIPNNDRKFVTIGNVANPRDELEAEFGPIGAQIFRDMQGEKANAGATDDPIEDQLRMADYLTAEPGSVEDLVAQRRFKMEALTEDEHEQFLEDLDEFVRKGQEVSMMPDDTDYIPPKKSKNEKVTSNLRIGEDQKSDMNEEEPEVRLDPNQHVHGEWSEMLITVGRTTKLWRGGRLESYRALVIGGNTNGCGGFGIGKSWDPVLAVDVAGRNCKKNIFFVDRYQNDGITRDLVGKQNSCIAKVMSRDNGLHGNPLMREILKRFGITNASCKAHGNRNPFNVVRATFKALMTHESLEDIALKRGKRILSLDRAMRMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG7</accession>
    <name>B7FQG7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_9017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176869.1">
        <property type="nucleotide sequence ID" value="XM_002176833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG7"/>
    <dbReference type="FunCoup" id="B7FQG7">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQG7"/>
    <dbReference type="PaxDb" id="2850-Phatr9017"/>
    <dbReference type="GeneID" id="7196849"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9017"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069001_3_0_1"/>
    <dbReference type="InParanoid" id="B7FQG7"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="134" mass="14555" checksum="A8087B215C76979D" modified="2009-02-10" version="1" fragment="single">VYLNVYDLSPANDYLYAIGLGLHHSGVEVSGTEYSFASGAGVFDSPPKVAPGAKFRQQIEVGAFDGGPGKLQQALTELRVDFGPDDYNLVRKNCNHFANALCWKLVRTTIPGHVNRLSDIGVCCSCLLPRQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQH6</accession>
    <name>B7FQH6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_17794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177405.1">
        <property type="nucleotide sequence ID" value="XM_002177369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQH6"/>
    <dbReference type="STRING" id="556484.B7FQH6"/>
    <dbReference type="PaxDb" id="2850-Phatr17794"/>
    <dbReference type="GeneID" id="7196251"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17794"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQH6"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="197"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31452" checksum="7BE7DC87889CD7DA" modified="2009-02-10" version="1" fragment="single">MKLPKEVRNIVAGGFAGMLAKSVVAPIDRVKILYQVSCAKFHLRNVPKVMKNIIRDEGFAALWKGNAATMIRVFPYSGIQFMVFDRASSSAPSSRRRFGLTPLESLISGMVAGTVSVMLTYPLDLTRAQLAVLRRHRHAANRGFVSVLTDNYTQRGPLGLFRGVVPTLIGILPYSGIAFALNEQAKREVQHMTQRDLTTIERMQCGAFSGLIAQSITYPIEVTRRRMQTIGLVETLPSLVGTIRSLYAEQGLRGFFKGVSMNWMKGPIAFSISFTAFDTLQSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR40</accession>
    <name>B7FR40_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_8828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176977.1">
        <property type="nucleotide sequence ID" value="XM_002176941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR40"/>
    <dbReference type="FunCoup" id="B7FR40">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FR40"/>
    <dbReference type="PaxDb" id="2850-Phatr8828"/>
    <dbReference type="GeneID" id="7196962"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8828"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_1_1_1"/>
    <dbReference type="InParanoid" id="B7FR40"/>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="32272" checksum="A3CC5B745773B581" modified="2009-02-10" version="1">MTNERILSIQSHVVSGYVGNKAAVFPLQLLGFDVDVVNSVHFSNHTGYTNGWEGDVLKGEQLRAILDGLDRNGLLSSVGHVLTGYIGSISFLEAVLDVIKTIRMKHKVRFVCDPVLGDKGEFYVPKELVQVYREKVIPIADVLTPNQFEVEQLTGIDVKTLNDAKMACQALHDMGPSLIFITSCEFSEREMSILASQRRENEIQLWHIACPILAGHFTGTGDLCASLLLAHTARDPDNLPAAMEKVINTMFAVIERTSKNGGDSVQSRELRLVQSKLDIENPPQRFKAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR45</accession>
    <name>B7FR45_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_8765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176980.1">
        <property type="nucleotide sequence ID" value="XM_002176944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR45"/>
    <dbReference type="STRING" id="556484.B7FR45"/>
    <dbReference type="PaxDb" id="2850-Phatr8765"/>
    <dbReference type="GeneID" id="7196964"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8765"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_0_1_1"/>
    <dbReference type="InParanoid" id="B7FR45"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="287" mass="30856" checksum="738C98BAFD9BB68A" modified="2009-02-10" version="1" fragment="single">MTKVSALSLTSKRRHGKKISMVTAYDYPSAVHVARAGMDILLVGDSVAMVELGYENTQPITLRDMLHHCATVKRGVTAVASQVSQVPLLVGDMPFGTYEYQDTDVALRNAYAFVKEAGMDAVKLEGGSKARAQTAQRIVEGGVAVMGHVGLTPQAISVLGGFRAQGRTAVRARQLVDEALRLQDAGVFAVVLECVPSNVARSITDTLEIPTIGIGAGPHTSGQVLVYHDMLGMTSHPHHDQFVPKFCKKYAQVGHMIQEGLLEFKADVENGTFPSDAFSPYVMTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRT5</accession>
    <name>B7FRT5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177551.1">
        <property type="nucleotide sequence ID" value="XM_002177515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRT5"/>
    <dbReference type="PaxDb" id="2850-Phatr43305"/>
    <dbReference type="GeneID" id="7197075"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43305"/>
    <dbReference type="HOGENOM" id="CLU_907513_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRT5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="307" mass="32805" checksum="BD9AB61835AFF2E7" modified="2009-02-10" version="1">MPSNNNSSASELAVYANLVSYKYDGDSKTHSANRGGDANDMSVYGNAVKVSLHGLPVAGLTDDDDDSSVVNDGRLLVKDPQVVAAQEEDVKDEQSISVDESQLLSTRKAFAPCTDPNSIIKVSLDHRRGFLGRRGNVRVLDSAGKPFAGGVHLKEFQRHLLRPSYLLRTANKTPVALCVQQNAQTGSSTKVFNIYSTRQGVTADVTKVVHVAGVSYYPAYRVELASAASDCVVSTWTGKESVPIWELRTDANTVTIQDINVGRILGSIEQHEGLKTGCDIVLNAGVDPALVLCVGTILEASCTAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS00</accession>
    <name>B7FS00_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2061 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177892.1">
        <property type="nucleotide sequence ID" value="XM_002177856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS00"/>
    <dbReference type="PaxDb" id="2850-Phatr43360"/>
    <dbReference type="GeneID" id="7197402"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43360"/>
    <dbReference type="eggNOG" id="ENOG502S6IU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1121921_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS00"/>
    <dbReference type="OMA" id="YERVWAK"/>
    <dbReference type="OrthoDB" id="200262at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018638">
        <property type="entry name" value="DUF2061_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09834">
        <property type="entry name" value="DUF2061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855254" description="DUF2061 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2061" evidence="3">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2061" evidence="3">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="248" mass="27431" checksum="0A6DB499AC60A613" modified="2009-02-10" version="1">MKAFSLLVLLSLQWQNSVGFGTHAPLRTLPVARLANTRSMSTAAISDSNDETVLKQFEKKELQLLKRKQEALAKLEEYTKTLENLQSQKAEYLAAGQVADASAAGSFSETALRSAVKAFLWRIIAGSITFATTLQFSGSVKTAMQVVAGDFFSKAFTMFIGERLMNKSQAGRKKGADDVGRSFAKALIWRLFAICNTLTMAVFISKDLSVASKIASTDAVFKTALMFFYERVWAKVKWGKDYLLEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSX8</accession>
    <name>B7FSX8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178059.1">
        <property type="nucleotide sequence ID" value="XM_002178023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSX8"/>
    <dbReference type="PaxDb" id="2850-Phatr43631"/>
    <dbReference type="GeneID" id="7197347"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43631"/>
    <dbReference type="eggNOG" id="ENOG502R7UK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827598_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSX8"/>
    <dbReference type="OrthoDB" id="46682at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855390" description="RING-type domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="479" mass="53489" checksum="5615DEBC08316F7C" modified="2009-02-10" version="1">MKTRGHCGVFSLLLATVAFNEFLAVSAYSASFARAAGLDSIAPWRYSQYPSPFEYPTVCRTTSEKLCDPDGILNDSEVERVDRVLKTSREFVLPCKAESNVEGIKGRVINIEIAVALVKQMDLLEFEMNSKQHERAAEVFARSLHNEWGVGVTNSCGGTGILLFLSDLDRVIYVSRGTALKTILTDRRLDRAMNKMKPLLQEKKFEEAILSAVEEFEFLIQYGKPHTWELINDYITRYGGLCWVAVFLVFAGRNIHVQTKKQREYAKVRSHLSEMDRARAEALQGRFCATSCPICLEPFPDHATTSTRTPEQLGSDNLPIKLLRCGHVFDHNCWLEWASKGQGQVTKCPICQQDVGMGEDLTTARNTQSLSRRSSRVVSDDLDDSIGHRGLAAEGERFLNLHNRERSFRLTQLGYQFPQIIGPHQIQQWSQNDYNGMLVQDPTFISSDPVSGVGSSARGVGIKSSFSGGSSGGGRCGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTD7</accession>
    <name>B7FTD7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177824.1">
        <property type="nucleotide sequence ID" value="XM_002177788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTD7"/>
    <dbReference type="PaxDb" id="2850-Phatr43763"/>
    <dbReference type="GeneID" id="7197277"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43763"/>
    <dbReference type="eggNOG" id="ENOG502RADF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599176_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTD7"/>
    <dbReference type="OMA" id="HQLNWLE"/>
    <dbReference type="OrthoDB" id="269605at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="457" mass="52270" checksum="82EB5DA7DDDEEF05" modified="2009-02-10" version="1">MRFTKMLEKAATAVTTSKKRNFKSLALSVYFKQPDLGMKDYEILSRASAFLLGIDPPERKPEGPYGHLEILEERRKTREFQHRKKFTPAGGEGREIMDLSWLEFVPREVRPQVHIVASSHVLSPFLWKDYYPQDWLTQVRQEHCTYALEVFDSENPNESLAKIGLDSTPFHHPEGRDISVIHFKEEESSLKTLKNLGVKIQYLRSPEKMYEKGETMYFDGYVVSEPNTADDQQYGSKPVNHGNTNDKIEDLRVFYPHKEIGKLSFHTNDRFFATTPEPLPEGLCGAPVLDSDGELCGTVEGIVPVDHKDERLAGSAAFIPSYVLASFVDYVERGLLQLIMPEDLFQMAVTAKKTNSIGGGLFKADKDGNYTKETNWEEAHDRALKALKKRYTQKEVDAILDTVAEESKEVLEIMDREGGDMDEIVQRVRAKTMQIRAMVRDQYEKKQSAESMREEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTR1</accession>
    <name>B7FTR1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178461.1">
        <property type="nucleotide sequence ID" value="XM_002178425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTR1"/>
    <dbReference type="SMR" id="B7FTR1"/>
    <dbReference type="STRING" id="556484.B7FTR1"/>
    <dbReference type="PaxDb" id="2850-Phatr44331"/>
    <dbReference type="GeneID" id="7198027"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44331"/>
    <dbReference type="HOGENOM" id="CLU_1100305_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTR1"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042:SF11">
        <property type="entry name" value="OS06G0173800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27714" checksum="E487D057922F7D5D" modified="2009-02-10" version="1">MTNLSHTDPTTVVHTSSHSFIESTKYRPRERLLREHPSASANDMARSAGSVRTDPHPTEHAPLAVVGSPHRTGRWTLDEKILFLYGLRKFGKGKWKKMSAYLPNRSLVQIKSHAQKVLKRIDQGEHVFRRIEENNARLELLVASIHDRLGHEAPALLLPKTAAANKRPRRSVVSPKVDPPIPAVELDAQQHIIAASALCQLAAPTGPGAWDTPTTCPPGSTGSSPVLHPDHTTPSQTWIPPSDSQTDLSVQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTU0</accession>
    <name>B7FTU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_18893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178478.1">
        <property type="nucleotide sequence ID" value="XM_002178442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTU0"/>
    <dbReference type="STRING" id="556484.B7FTU0"/>
    <dbReference type="PaxDb" id="2850-Phatr18893"/>
    <dbReference type="GeneID" id="7197832"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18893"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="InParanoid" id="B7FTU0"/>
    <dbReference type="OMA" id="KGMTAHY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="38"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="363" mass="38408" checksum="99EEB107A016DAA8" modified="2009-02-10" version="1">MFVAFQTISRNSSLTGVLRRSMSSIPSTMKAAVVRETGDAHALKVETDFPTPSLGANQVIVKNEFAGINFIDTYHRKGLYARDLPFIGGQEGGGTVAAVSDEAAAQGINVGDRVAYSVFGSYAEYTAVPAAKLLPVPDSIGLDVATSCVVQGLTAHYLVTSAHADLIKSGEWCLIHGVAGGTCQWAAQMAKLRGFKVIGTAPKGKADIASNLGCDELILLDEVAGTSYEDYESVDVTAKVLEITGGAGVKCVIDGIGKATMDISINSLARRGIFVSFGNASGAVPAFPVLRLIGKSAYVTRPKLLDYTVDREELVWRAGEVFDWLQAGKLKVAVDTTFSLDDAAEGHMYLEAGKSKGKVLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU37</accession>
    <name>B7FU37_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178249.1">
        <property type="nucleotide sequence ID" value="XM_002178213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU37"/>
    <dbReference type="PaxDb" id="2850-Phatr44437"/>
    <dbReference type="GeneID" id="7197886"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44437"/>
    <dbReference type="eggNOG" id="ENOG502S5EE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034257_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU37"/>
    <dbReference type="OrthoDB" id="197739at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="557" mass="59243" checksum="3BEB887229BD07DF" modified="2009-02-10" version="1">MMLWWNRRSRIGYIGIPAVLIGIMTSSVNTYAVSLRTIPVFSTPVAAQMGESALRQVEFLGRLVSEKEQEIQQQQASIPNNRGPINVDGTGKSVYNTQKRMSLERPSLSDRPAPKQRQVWEALESLEQDMQLLDNLAGQRPQLSALEAVLLSAAVLSAAGGPLLLGGHITEFLAPFAAAFTAAIGIGAEYTGKVAVADGKEIAASTIQCAAEAEGYLANAERAKAITPLCVGIGATAATFALLVPVLLDSIGAATNLQLMTEIYLCCPLISVLAAAVASLALQETRSFSEKAIGIGNRRFARSGLVGRTWLSSTELIERKSASAANRWRTFSLSVLPAPLIGALVPGALPTKTIIVAALAAAESAFFLAQCESVLSRATDAVALKARSAAVCDTYANQGARSAAILPFTSALASLCAAATAAMVELPFIETLLSTGTVASTAASMVTVAIFPALSALFAAAASVSKARCEVDAEAAMQAASTIALQYEDQEEDPVLKPFRAVRELIRLTLANSIKEPLRRLFRRYNFRRRFTVLRKWFRRDVLRRSNGTRGPTPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU50</accession>
    <name>B7FU50_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178257.1">
        <property type="nucleotide sequence ID" value="XM_002178221.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FU50"/>
    <dbReference type="PaxDb" id="2850-Phatr44446"/>
    <dbReference type="GeneID" id="7197685"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44446"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257497_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU50"/>
    <dbReference type="OrthoDB" id="43068at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="292"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1354" mass="153644" checksum="C7733940F1DD75BB" modified="2009-02-10" version="1">MLARSIGSSTARLRLTNSKDFAGVDRARQVVRDFSSWQQRQQVRFHSFARITPGLVSSSDLVENSCCRRSTENPLFQQVRWKRKDGHKAFGRERPPTKAQRKRYNRSLQAKESKHGVPGSKAGIRREWEAERREDIMNPPPDLQLDDMEYGMGDAMLDDLMGNTAYLTAQETPEPAYLGHLHKKFFSQAANRMQTYKDQLERLSDPNSDTSQLVAADRVEMPNDKNISLALRAFRDRYGTKRQPIGMVKALEHLVKDIGVPITAFGENTYTTLMTCSRSPAEARRIIDLMRKEQHPVSSYSWSILVDTYAKAGDFKGCANAQLEMINDGIPPTLVSFTSLLAACAKVCNDGRVAHSIRAQAGKLGWEKWQEMRVVGVHPDVMAYGAMLKLTAARGHPERAINILEEMQQMDVKPTTLCFSYALRAVAKSHSTSIRYERGASRKMKRREFLTHHHGKLARSIVLLAENAEVKQDQGFVSALIMCAAAAGDVATAKAIYIASQIRQLDELRTIGSDQHLARLRGEDIHQYEGGLLEDPSLSNTNSSLSLPPQNMGRKYPSFEEREYGKDSRVLSAILHACACAVDKNGIGDMWQGRENQGYLCENSLRLLKARQVPKFVDNSIPGQTRTDALKWEGEYRDEDYRGKKRSPRKFRGVEEDIEAGTTLDQVDGDIARMYEDKEGRLKKEYRSTSFEDVWKLKYGEDWANDSGTKRIEERPMFNLESGLTSTGTGDASVRDDGTNEIEEQMFFDRESMRWTTIPLSERTKTRPSSVEINLPAVEGPPPEHEEMYFHKETSRWMTRAVTPSNMTPETEKNMSQAVSPSESRDAQEAVDFDDSNEDLYFDKDERRWKTRSRADAENARRTAFENQILQAKSQPNTKMADREKVDTEKTVKKGHEFQIFYSELRKEMQESGETIDDLTEDEAYELFLSAEEEYNEMMDMDPDEFSTLIDELDDEELATLSSKSLPEPESALSSNLGAAEIKSKQELHAKIEELKDEWDDSDDAPDDMFEPSFSPSSYKSVHSQSSPVREKTFLEEPTVTTTHAAQEPTISSVRVLDAEYVEKPLTGQSPSPKNVGLEQIAGGRDVFPGAFQEHAAATDAESFTKIDEQLELLRGMLPGFSDKRLSKIRKAFRSSLGDPSLLELTLIAREQMPDYITNNWLKHMSSLTSRYIMHKAVEEEKIDVHVLNAVLELDTAAGSLDRALQFYETEFAIRNLEPTAYSARLVIQMFVKNKRLQRALTFKNSIEMRGRTLDILSYGALIDYCSRHEQLGSALLLLKECLSKHEAPPGEAYLKHVRLLCRQADLIEEIGLEDMIGKDPIEWLRHGEANLKRDMSKKGRRDINLGRNRLMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUC7</accession>
    <name>B7FUC7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_10722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178298.1">
        <property type="nucleotide sequence ID" value="XM_002178262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUC7"/>
    <dbReference type="STRING" id="556484.B7FUC7"/>
    <dbReference type="PaxDb" id="2850-Phatr10722"/>
    <dbReference type="GeneID" id="7197775"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10722"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362284_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUC7"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF3">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="153" mass="16399" checksum="02A0C76C20459190" modified="2009-02-10" version="1" fragment="single">MLLRNLQNMGCERSLSVQDKACPDVLEGKDVLVGTYTGSGKTLAFLAPLAQRILNDDGPDGSLRVLVVAPGRELASQIISVARSLLEGTSITTMLAIGGTTFGRNLEQIRKRKPSILIGTPGRIAELVVGQPGDRTGRLKTQKLQSLVLDEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUE5</accession>
    <name>B7FUE5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178581.1">
        <property type="nucleotide sequence ID" value="XM_002178545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUE5"/>
    <dbReference type="STRING" id="556484.B7FUE5"/>
    <dbReference type="PaxDb" id="2850-Phatr44524"/>
    <dbReference type="GeneID" id="7197783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44524"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433118_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUE5"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="164" mass="18846" checksum="662294D572104267" modified="2009-02-10" version="1">MDDFDMGLLDDNTYKVSVLRQKMLGIAPVFMYRIPKVSDADDEYLANEWNLRKPLQQCSLRIERRGDVLLVVFTYKNEGSPPKLFAVSKILLDDYDLSHFVQPVGDSSRYFAIRVTDEKEGREAVIGLGFREREEAADFSQCLINFNSAIFKERLARGAEMAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUF0</accession>
    <name>B7FUF0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178583.1">
        <property type="nucleotide sequence ID" value="XM_002178547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUF0"/>
    <dbReference type="STRING" id="556484.B7FUF0"/>
    <dbReference type="PaxDb" id="2850-Phatr44529"/>
    <dbReference type="GeneID" id="7198065"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44529"/>
    <dbReference type="eggNOG" id="ENOG502QRI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666475_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUF0"/>
    <dbReference type="OMA" id="FFCPRAS"/>
    <dbReference type="OrthoDB" id="5696at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855334" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="360" mass="39829" checksum="07D9741AADD0762A" modified="2009-02-10" version="1">MGLLSFLLCLKALQTATAFGRQPLRTMRAYAPRSLRSTPLPLAGQATELPDSLEDAATRAAQATANFASQSGPLARCRVDFDTSVGDETYTLLKSSTEFMQNFVSALCYATIPGLQEQRQAEMMKVAEARAELKVLFQENPEDDRVRELQKMLAANGRDPDAGPWTGPVARVYFPDEGSAALARRDWLGVDPKVPPCVQFASCGGVQVGDIQKDRIVFFFCPKASESEYVEKILINTETTATDLQLSVLVNPNLVDMGVTGFGMAGRRLRERLIDPLQNTYYLRTLPWGALTRLWPQAYSVWQEDTDAEGGYRLIKTLGRLPSNPEVEDIYDIENGNMEARQSGGPLDQLADFVNGMMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUX9</accession>
    <name>B7FUX9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178398.1">
        <property type="nucleotide sequence ID" value="XM_002178362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUX9"/>
    <dbReference type="PaxDb" id="2850-Phatr44688"/>
    <dbReference type="GeneID" id="7197894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44688"/>
    <dbReference type="HOGENOM" id="CLU_505769_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUX9"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="56"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="539" mass="60157" checksum="F05A5875F467BF62" modified="2009-02-10" version="1">MAPPIPTTTTRGRRESAPDWVLTNYDVDTSVPPDVETELRRLRVLQSYDILDREWDTAYDRLAQIAARALQTPTALVGVVDLGRYWRVALHNCNSNIHHSNNHHHRDAPRELPRKQAIASHVILQRQGYLVVMNVGKDSRFVDHPAVRNGTFQFYAGVVLRSPEGYPLGVLAVTDTQPRLHGVSHEQLQTLRDLADALVDLMHTRRRPKGDTGPAAITRPTAPASTTTTTPPSNPPSPTNHTNTKDTNNSSSWGVQRSARFLRQYLAKLNDDSTLENVLTKDQRELLRSSYDAAAFLHGSLLPPEQRQELVRENRPDQVTSVQIASLVQSVELAMDAFPKTVPVRYQIDDEQIPPFVLLVELKIFRSCIALLTSACERTRQGVVCLRVFVQQRTVTQKELVFECEDTGPDVELEQYDDLFDAPLDHTADVGEEDCIRADPHTGKIRKALRCATVPNSRRGHGVHALADFIGSIEGGDYGFRPRETEDFEPHGTGTGSVFWFSIALHTPPATRHGTDAVVPRRPQPWIISSARGHGSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVZ2</accession>
    <name>B7FVZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178790.1">
        <property type="nucleotide sequence ID" value="XM_002178754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVZ2"/>
    <dbReference type="STRING" id="556484.B7FVZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr44879"/>
    <dbReference type="GeneID" id="7199805"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44879"/>
    <dbReference type="eggNOG" id="ENOG502SNGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482761_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVZ2"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59602" checksum="F5AD3D4CEAEB8BA9" modified="2009-02-10" version="1">MSKMTGNGSPARIFWVWTILTFMLADWFGLDGTVPFGRVAAREIVATREWTLLRENDTVAAGMHVRMDLSTGEKWVKLPDEDDNDENNAAAAVEIQPNDGAEVSFTAQHQTSPTDPQAEQQSIHAYDFVKMHETLTSLPEDEQARMGGIPALPGSTLSSLTPEQREAFATRMAQLWEERQAELREFQAEFEADLPAILRTRIAQLQDYLRDPSADALDPSQSIIVSVLRDLEDQLVDLDMARDFHTLGGWPVLVALVTDDAHQPPFWQQSPNQTDTSTETASHVRSIQAHAAWVLGTAVKNTGEFAPWALEELTLGNESSIARQTIATTSTLRVVLDQFLASTLPQETSPALEQLQVKTLYALGSLLRGNALAQARFLRDYHGPDQLASRVNTLLATGDVRGVSRHTTKLTNRLMALATDLLAEANAVTSQPEHASAEPQSKQRFLSDELITSFTTQPWCSSLLTALEQPPLQETALTVVVALAAHCDWDDLRLVEEVLVDIRAKCHGKDTGDNASPEDSFHEERASLASEALQLLRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW14</accession>
    <name>B7FW14_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178805.1">
        <property type="nucleotide sequence ID" value="XM_002178769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW14"/>
    <dbReference type="STRING" id="556484.B7FW14"/>
    <dbReference type="PaxDb" id="2850-Phatr44892"/>
    <dbReference type="GeneID" id="7199596"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44892"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FW14"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="252"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="755" mass="79812" checksum="99CA763C8A3AFC11" modified="2009-02-10" version="1">MPAATANKSKMDKQQPKQQRPQPVMSKAAPATPKQNAWSKPLKAVPSAPPGLGGPRPTAPSTKAPSEAETATFVALRERYLGLCLNLVGHKVVVHLRDGRQLEGIFHTATSFASIDAKLRNQYVLKGTQTVKATTADSKANTVTPIQPNATVVLDMSKVVSLHCKSIRLQHQVPSSSVDNSFTDTEISKGAARTNDAGLVAAGAAWTTPTAKAGGGIDTPVSTAGTVTPRSTTGLKASIGGWDQFRANKELFNVTASFDENQYTTVLDKNTVDAQKLREAEKLAAEIEKSVSTNWHVAEERNQVVQGDFDEEDRYSGVIREEKAKSPAGKSATVPAATKAPEAEPVAAVQKKTMNYAAAASKKAEPQAVVVPHAVVEAKKKTEPPATLKKANKATPTITTPALTAKAAESKTDVPAKQVTQSAEDKPSTETTSEEPVKETAKEEEKPKSKLNANASSFSFNINAKSFTPGTPAAPPAAFPDQSYAIDPHTGMPLQQYMNLPPHIGQPAMMHMMNPGVRYPYPGMEHHHVPPHQQQQVHSPAKTGSIVSPVPSQEAAPVTEDGSVASGAAISQPQDGEATEMTPQNAPQPYPVHPSQYPAMPPRGGISGYHPQMYPGQYMHPPPNPMYHLPPHRPMYPMPPTVPPNMMRPYGQAYSNAPMPYGYYEDDGNGAGTGGRGGRGGGRGGRGNGRGGRGGRLYAGRDGGRGRGQTGGRFQSPPTGPAHPTDADTLEPAPLTDPTPAMAAGATPNTEEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW40</accession>
    <name>B7FW40_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178818.1">
        <property type="nucleotide sequence ID" value="XM_002178782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW40"/>
    <dbReference type="STRING" id="556484.B7FW40"/>
    <dbReference type="PaxDb" id="2850-Phatr11403"/>
    <dbReference type="GeneID" id="7199609"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11403"/>
    <dbReference type="eggNOG" id="KOG0584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264875_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW40"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001565">
        <property type="entry name" value="WNK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000427">
        <property type="entry name" value="Wnk protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="294" mass="33669" checksum="D75039BDDD35E4F9" modified="2009-02-10" version="1" fragment="single">MDDYIKSPEVQNAIVERSPGGRYVRFMEKLGSGASKDVYRAYDTQEGIEVAWNVVNLSGVPKSERNRIVNEVRLLERLHHHNIISFHGSWVNRERQEVNFVTEILSSGTLKSFISKVQVIRWKIAKRWALQILNGLDYLHSQNPPVIHRDLKCDNIFINGTSGDLRIGDLGLSTVHRTGRVLSVLGTPEFMAPDMYEEHSYDEKVDIYAFGMCMLEILTQEIPYSECNNPAQIYKRVSSGEPPEVLSRLQSRHAREFVRLCLGRKDEAGKFVRPSASDLIKHPFLVKRNTDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW73</accession>
    <name>B7FW73_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179053.1">
        <property type="nucleotide sequence ID" value="XM_002179017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW73"/>
    <dbReference type="STRING" id="556484.B7FW73"/>
    <dbReference type="PaxDb" id="2850-Phatr11363"/>
    <dbReference type="GeneID" id="7199622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11363"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039532_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW73"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="106"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="213" mass="24263" checksum="A36359E36DBE0737" modified="2009-02-10" version="1" fragment="single">PTAPKYQYYQSDKVLTIAILEPHVQADDLHVAYNTQHLSVVLHKQGHEFAVLHGTLFDRIDVDRCQTVFRDEKVLLKLRKTEPAEWHELWSKNKSSDSVAPSTAPTVDRSKRATPYASPRDWSAIEKALAEEEANEKPQGDEAMNALFQQIYANADENTRRAMTKSYQTSGGTVLSTNWDEVSRKDYEKERVAPAGTEWKTWEGDKLPMADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWC7</accession>
    <name>B7FWC7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_7173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179359.1">
        <property type="nucleotide sequence ID" value="XM_002179323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWC7"/>
    <dbReference type="STRING" id="556484.B7FWC7"/>
    <dbReference type="PaxDb" id="2850-Phatr7173"/>
    <dbReference type="GeneID" id="7200077"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7173"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="InParanoid" id="B7FWC7"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="143" mass="15339" checksum="D54B175614EAC00E" modified="2009-02-10" version="1" fragment="single">DADLDGSAMRIGIIRTRWNDEHVTNLVDGIKEGLRACQVEEDNIFETSVPGAFELPMAARFLALSGTVDAIITTGVLIKGETMHFEYISDAVAKGIMNIGLQTSTPVIFGVLTCLDEAQVQARSSGDSNHGVDWGKTAVEMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWV0</accession>
    <name>B7FWV0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179443.1">
        <property type="nucleotide sequence ID" value="XM_002179407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWV0"/>
    <dbReference type="PaxDb" id="2850-Phatr45212"/>
    <dbReference type="GeneID" id="7200096"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45212"/>
    <dbReference type="eggNOG" id="ENOG502SCSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508545_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWV0"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="80493" checksum="E66833B457D2AC4C" modified="2009-02-10" version="1">MRAQGFWNSFIPWRKLTGAGSVAVGQVCCGDKFHAFLNDNKQKVQRSKTLQCSYGQYSEYILQSLLRLQTFEILPVARTLLESTRDEAHFKRNNRQIVKDTAKVYDFVIIGHGNCGRSALETLRRKCPSATVALVDPLRPLATAGADYYPCRVTALDPRSQAVQLETTDDVRYRHAVLLATGAHGAPIPHYLMDSKATSRVLEVRPSVLPSSDQRPIISPELVRKSVQQTAANGLRIGVLGSGWDAIDLVLVASNHGKTRPTIAFGNPGPASHMLPSYLSSAVARRLRTKKIEVLDRTLVRYISCEEENAELQIYTAKSYDFLDSFRTTVDLVVVAPEISGARGSAVLPTNNIPSHLESSRKGRSWYETWFNQAMSSVTDRGTVVCYKDDGRVSVNTELVVCSGVYAAGSVAKYANGLTGHADVAGVGIEDARSAGKVAAMNMGRQYRASSLLGSMKRDEELAVAHTKDPLPVWRSDLRSYAGNGSDRTSCLSEIGISCLAVGHCDSDRFATHAVWWTNQAAQRRLLRSLNEDLNEQLVHELKTAVLTNGGFGSLENELDQVRMSKYLESTSRRLVAIAFGGNTTAAPGRLLEGALDDFPRPLHRFTEVRPPSVRSHGLLKRKDGHGQGVLGEDLFARYQEPVADALPAQPIAGVGYASTQGTSGNRKSYAAAHEMYEWALWEQKEKRWDENEDVARPPKEDAIWIRKGDEQKNVAFKDTVAAAYSAAIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWX9</accession>
    <name>B7FWX9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rab18</name>
        <name evidence="9" type="ORF">PHATRDRAFT_51810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179241.1">
        <property type="nucleotide sequence ID" value="XM_002179205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWX9"/>
    <dbReference type="SMR" id="B7FWX9"/>
    <dbReference type="FunCoup" id="B7FWX9">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FWX9"/>
    <dbReference type="PaxDb" id="2850-Phatr51810"/>
    <dbReference type="GeneID" id="7200253"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51810"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="B7FWX9"/>
    <dbReference type="OMA" id="MEGDINL"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001312">
        <property type="entry name" value="Ras-related protein Rab-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="213" mass="24064" checksum="060D5D88A907818E" modified="2009-02-10" version="1" fragment="single">MAAPPPQTFPYDYLFKVLIIGDASVGKSSMLLRFTDDSFDEHIQSTIGVDFKVKHLEVEGKRVKLTIWDTAGQERFRTLTSSYYRGAHGVVLVYDVTRTDSFENLQQWLKEVQMYSPGNGESVVKLLVGNKCDLERQVPFEEADAWARSQGMLFLEASAKTRLGIRQVFTEVVKKMLENPETLATAVPGRPKVQIKPQHARPNMMDDEESGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWZ8</accession>
    <name>B7FWZ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179250.1">
        <property type="nucleotide sequence ID" value="XM_002179214.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr45249"/>
    <dbReference type="GeneID" id="7200263"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45249"/>
    <dbReference type="eggNOG" id="KOG4199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253095_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWZ8"/>
    <dbReference type="OMA" id="WNIAFDN"/>
    <dbReference type="OrthoDB" id="44362at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1421" mass="153526" checksum="67715BF0A0560E6A" modified="2009-02-10" version="1">MDSFGSFDQIEGSDAIPRYDQMGRLLSPDEREQIARRKGLCMRCGMKTHQGAFKRPLTDDNCYKGTCIRCNPNAVPKRVLESWNLKNRPANVQLVSGAAQANAVASGITLHGKHLLKKATRSVMAAGRATNKNGRVIPTGPSTTIAFTSEHSTSSNLKTGSGTSSEAQSSQTPLPQKSAPLLHAQDLHQPWIEGKRPSAHIPSLHSESSSMRQTSTSTIGKLSPTVSDRSLYSAESFASSASHVSTKCAASGCGIGTNNGNCGREPSVGADQNANDDLMASEYRQKPAKSAGLSNSVRLNSSRNDLDLSSPSNIRSKYLSNRSHSKMIEDDWTGGSQEMTHHTIIETLRAARADPVKLRQALHVLRNGLEVDLDGSLIIIARDILSQYVFDPSIADAACGAVWRITTLEDSLKSLAIESGIVGLLVDALKAHHEDATLCEWALGALTTLACSPFTKSDLAKTGVIEAVLELLDFHQNSAGILEWTSRCLHNLVHQYVVLDVEAAEEEMQAQIKKNISSIIEANGVSTLLNAMKLHATEPIALLWATKLMWRLFGRKEESSTVRVLFQLRQDGFVPLSTKLLRQQSTSSELFQLISRLVCMLLLKMDDGALYETASVAMPSIVRQMEEFKDDETLQEAGCRLLCALSTGGESVQENLKEADGILAIVKTMERLPENLMLLTRAGWCLWRLSANPSLFDSGLVEKSLQALSSAMDSHRDSVDLLVSTCGFSRNSTMVDGVSPTAYPLDVIFRWLTTEGQASHYKVQASQALHTLSRKYNDFLHLLNESVGIPRMIASLRDPQSCCRIDICCILTVLARNSEDSRQMLASADVVQTALAELAETNDLNWKACLLRLVSTILVSECALQIDVPIHAIQTAIGGVEGSTFDPSLSELACICVRNLLLTPNSRVGVEGLVKAMTDTIDTCAVSDSLCIEACYVIWALTSKYSDRNPSELSAMMTSLIGLMGKFMEPLNLEIQSAAAGTLASVLASIVRSPIPLKVQDVEVVISVIYKIIDTKPGASEAIEHLLAVLWNCCLVDENTLVQGGVVVAVIDTMVDNESNLQIQERGCTILALLASAENLEVNFSIAETNGVELLVSALAVFGDNVNVTLQACKCFSYLSIDPELRVMIVAQGGLRLVVVAITSNPDNAELVGFACSTLLNLTFDAEVSAYIGSGIVDAIVQTMTGHLKSALLQETGLGILQNISMRGPDEKARIAEAGGVEAVVSVLREHIRLPSVVERGLATLWSLAVLDENQIRVANADGINLVVNCMMALIEYERVQKQGCGCLCALAGDSTSKVLLRNAGGLDAIVFAMWAHFNKSGVQKEGCRAISNLVHDPGTNEIMLVSETEVGAILSAMRRFPSVADLQMHACYSLRNLTLSVDNVAVVLGSADDIRELVAKVSLRNPECSPIVNQILSHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXQ4</accession>
    <name>B7FXQ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179596.1">
        <property type="nucleotide sequence ID" value="XM_002179560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXQ4"/>
    <dbReference type="SMR" id="B7FXQ4"/>
    <dbReference type="PaxDb" id="2850-Phatr35154"/>
    <dbReference type="GeneID" id="7200685"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35154"/>
    <dbReference type="eggNOG" id="ENOG502SAWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_991972_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXQ4"/>
    <dbReference type="OMA" id="YYYPTNK"/>
    <dbReference type="OrthoDB" id="192718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855574" evidence="2">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="30623" checksum="54DF1A42F5DEBD3A" modified="2009-02-10" version="1">MRWTTTTTTLWILPTLASAWVSVGRDAPTRPPTNLAVSRRDFWTTTTAAAASAFLFPNTPASAGLLEDYGTDPSKIRDVAGEERERQKVAARAVAKAESDVEPNLRANYYYPTNKKRYLPRIKRCNDAIPDAADAIGTGDWLVVTDFANKIADDTILPMRLYTSSLVGGGTNVKVAFAKEMNKAADDFEKAQKKLVKATAKQDREASSVALEDLATALQTYRVAGKLLGPDGGGDIPSVDDIRRSACRVQGRTFEQRIKQRDSRVLQTNATPGIDAPNNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXX3</accession>
    <name>B7FXX3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_12217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179634.1">
        <property type="nucleotide sequence ID" value="XM_002179598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXX3"/>
    <dbReference type="STRING" id="556484.B7FXX3"/>
    <dbReference type="PaxDb" id="2850-Phatr12217"/>
    <dbReference type="GeneID" id="7200716"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12217"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055927_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXX3"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="22263" checksum="7265CF0A8336245D" modified="2009-02-10" version="1" fragment="single">TSVQQIDRLLQENYKWRNLNPFFVLDLDHVANKDDISRRYKALSLLLHPDKNRDNPRAQDAYDEVLKAKAALDDEHKASHVRQLIEQGMRQGKADFDRLGSSHGEQTLQSMQSKAVQKIFAQIEFKRREIEQRERNFSQREQQKEEDDLEKERSARTFDKNWKQEERVDKRIGSWRNFQNKRPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY23</accession>
    <name>B7FY23_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179663.1">
        <property type="nucleotide sequence ID" value="XM_002179627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY23"/>
    <dbReference type="STRING" id="556484.B7FY23"/>
    <dbReference type="PaxDb" id="2850-Phatr45549"/>
    <dbReference type="GeneID" id="7200736"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45549"/>
    <dbReference type="eggNOG" id="ENOG502S4FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515347_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY23"/>
    <dbReference type="OMA" id="SINEVRC"/>
    <dbReference type="OrthoDB" id="535128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF6">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE_RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855584" description="YqaJ viral recombinase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59608" checksum="CDA9AD414D3EDA2C" modified="2009-02-10" version="1">MWYLIGTALLSLAVIMADWCLDAFTPARDRGLAPSQLLVATLSRKTKKPAASKTSNLLVPSQVMNGRNCVAQNADTSESEAVQSESEIRTLIETPSVASTANSIRRNRRQRRPKQPAVNKKKATIASFPATGNLPDIFWRAVPMDHLREHPRFVPLPQPEFVAKLSCLEDARLFQQGSWQWDALHNGRCTTSQAVAALGFLEPTAAEVLGVPPAWRRGGGGAFHRLGKPALRTLDEMNAILCEGAKANSTTIDEVTDLWDDDDVQNTTFFARYLHETDDEEIKERTEQLRRLGQGDYLDKAVRLLWGNTQEATALLTAINYFTKTDKKVVLKEVGMCGAGLDLNQTDLRSSLLIGATPDGVLHYDDGSIEAVEVKNHCPFYSNRGRKRNGGNIKRFSVGNWPWKDTSGVFSQYIPQLQMEMLCLGTGCRSAVMVRQSATNGALILRMKRDDEWIEEMLYWLHRFQCDYVEAKKAPPRDFFWDSPEKMDRSRYRRFVNRTAEIRNAVKLVAEIPNDQIQRVEEDAPMFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYC2</accession>
    <name>B7FYC2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179910.1">
        <property type="nucleotide sequence ID" value="XM_002179874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYC2"/>
    <dbReference type="PaxDb" id="2850-Phatr45632"/>
    <dbReference type="GeneID" id="7200668"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45632"/>
    <dbReference type="HOGENOM" id="CLU_706906_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYC2"/>
    <dbReference type="OrthoDB" id="49316at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="429" mass="48646" checksum="614FCA2424DA595D" modified="2009-02-10" version="1">MGCLLSWRDSNNLRIQGLRKRQATGCATVCSYQVTKSTMMTALTQRNHHHCGIGGCNETENLNTHTNPHADIGPEINLCPTPRMIQNSTDTLPLGDSDEEVSGSAIPPRSPKSCSELPNLPCFTRSPQPIKRHRSLPSPNRRFIFGQFWEKNECDEEVHFSKVPPTTDVSATSSTSTNPQGAGRPVATINNFDIRCLAPPAHRRVQSEYFRDIHELSPHSKQSLPRLPAPLMRFYHQGTRTSLNGMYPMNTPRSILRESSYRRLITSNHDTSPRNQAAFVDMGHRNGSFNLTRTLRQFPLSKSEQEDCSLHSDTASTSISQDCTSKKVQFDPRVVVTEFEDNIPREWFNEQELERFQCDTIMLARRYLLNHPELIPEYSRPKLDPVTCTLRKKALFSMPILSSDDDLLPRSPPVPGIVKTSRWHEVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYJ9</accession>
    <name>B7FYJ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_12118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179754.1">
        <property type="nucleotide sequence ID" value="XM_002179718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYJ9"/>
    <dbReference type="STRING" id="556484.B7FYJ9"/>
    <dbReference type="PaxDb" id="2850-Phatr12118"/>
    <dbReference type="GeneID" id="7200433"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12118"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579418_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYJ9"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="15548" checksum="FF29FC858D37AAB0" modified="2009-02-10" version="1" fragment="single">KYERIQILGKGSFGIVWMARRSDSPEGEFDEKYVAVKNIHIKNEKSNVYAEREISILQELCHPNVIRLIRSYPLHGGSRLVVMQLARGPNLHQLVIKRGAIGMPLARLICRQLIAAVSYLHGRAVIHRDIKPSNCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYL9</accession>
    <name>B7FYL9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179767.1">
        <property type="nucleotide sequence ID" value="XM_002179731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYL9"/>
    <dbReference type="PaxDb" id="2850-Phatr45712"/>
    <dbReference type="GeneID" id="7200517"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45712"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569224_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYL9"/>
    <dbReference type="OrthoDB" id="206708at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="480" mass="54642" checksum="58C1FE827B011207" modified="2009-02-10" version="1">MPSRSVIEVDVLIPVHNATDTLRATIESAMNQEPSHDDDNVEIQIDLDVHICCYDDGSTDTSWSILKDLEDQHMKNSRQCSSICCDGSKRSRVLTKLWLGKEATSRGAGYARNRAAQLRPNPNPDGFLCWLDSDDLMAPTRIYRQVQYLLSLEEEARKRALLGCTFERDPPDSTWHYSAWANGLTDDRLSLERFRELTIIQPSWMMQRSRFAEVGGYVEAPPLNDSDDSVECSVSIQKFELIHPVFDTPTTLRLAEDLRFFHAHLHSNGTLNLLRHDPPLVIYRHRAGLSQSTTTPRKLLLQLRTLAFERMVLESGEIWKENGFCIWGAGRDGKDFVKALSDTNRKRIRCMVDVDDRKIAIGSYVNRDIRVNIPIMHFSLLAKDESLRSSLYEQWTTGQNHNLPGFGKIRKGRNLTGPQGLPSAKKPKLSNKGSVDPQFKSLLRELPVVVCVSMYRTNGALEHNVKQIGRIEGEDLWHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYP8</accession>
    <name>B7FYP8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_45795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180011.1">
        <property type="nucleotide sequence ID" value="XM_002179975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYP8"/>
    <dbReference type="STRING" id="556484.B7FYP8"/>
    <dbReference type="PaxDb" id="2850-Phatr45795"/>
    <dbReference type="GeneID" id="7200807"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45795"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380144_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYP8"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="666" mass="74175" checksum="9A3AB0C4D7F843FF" modified="2009-02-10" version="1">MTDSPFRYDEALLRACASSNPESQTASLNDPHTVSQTLSAADTSFLLRLEEDTIRSTAKSAKDCCIVLFRQHAEHYGRRIPLGGTRAMTDDYNVFQRFQNFVQNVVFVHEHNTEACRHPEQHTVTLNRFSDQKMDEVLPDSDSDAGHVWPHGRSLWESWPFSEDGDEWNLENEGVLTHLSSPEMIYDVSANLAIGHGSMNRLKPKKKKTTVQDGPSQVLRIPVNDPVQLQPFQVLEGYDSDNDGALLSIKMSKHYKRSKAAVVDQTEEEKTDDYGTYLNWATGSNPDGVPIVHGAFDQGLCGSCWAFAAAGSLEASASRRAAYDAYKGYQTTFFRQPSNETARTRAIAYAQQIELEAFQMLNLSVQELLDCDVAADQGCTGGNPLLSFYYIHKYGLTSWQDYPYVGFQDVCHKDRVKRPVATVKSWGIISSNHEDHMELVLRFIGPVAVGVNGASSSFLSYKGGVYDMPSCKQTANHALLIVGYGQEVQIGGNVTRYWIARNSWGTGWGENGYIRVQRGDGRKGTPGVCGIARSPSVALGGLLLKERSITFTYGALGRSGEGSDYPVQHFCTRWGFDPESLCGSLATWVDLHKATTLGLLGIFVGLLALWPLSTDCRRRRRRRLLREQKRQEQLDQTCLPIEEASLLVKSKTHYANHKEYGAANQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYU4</accession>
    <name>B7FYU4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180040.1">
        <property type="nucleotide sequence ID" value="XM_002180004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYU4"/>
    <dbReference type="PaxDb" id="2850-Phatr45833"/>
    <dbReference type="GeneID" id="7201082"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45833"/>
    <dbReference type="eggNOG" id="ENOG502SQ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1351208_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYU4"/>
    <dbReference type="OMA" id="CAISGPM"/>
    <dbReference type="OrthoDB" id="200045at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852777" evidence="2">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="203" mass="20948" checksum="F90EA3150E16EC95" modified="2009-02-10" version="1">MKSTAIAVVLAISWSFSAAFTAPLRSNVGRTTGVRSAPTPPIPSVPLTQRRAIVQDLDVVALVAGQENYGLAVVCVGEALWSFLQAPSLDHAKVLVPAAVAALVLGLVSGPMVTSGDAATVGTGLWIATGVSLGLGASYVARMTAKYSPSPKEIAAFGLLVAVAGFFSFSQNLVVDGFVVLPSIPFPELPSLKLGQGDYIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYY9</accession>
    <name>B7FYY9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_12254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180251.1">
        <property type="nucleotide sequence ID" value="XM_002180215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYY9"/>
    <dbReference type="STRING" id="556484.B7FYY9"/>
    <dbReference type="PaxDb" id="2850-Phatr12254"/>
    <dbReference type="GeneID" id="7201105"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12254"/>
    <dbReference type="eggNOG" id="KOG0543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_0_2_1"/>
    <dbReference type="InParanoid" id="B7FYY9"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="112" mass="11808" checksum="65493CFD0DF136D9" modified="2009-02-10" version="1" fragment="single">EEAKQTDSGLVFCPMTEGEGKTPTATSTVEVHYHGTLADGTVFDSSVDRGQTISFPLNGVIKGWTEGLQLMKEGGKATLICPSELAYGEAGSGDVIPPGATLKFEVELFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ04</accession>
    <name>B7FZ04_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180259.1">
        <property type="nucleotide sequence ID" value="XM_002180223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ04"/>
    <dbReference type="STRING" id="556484.B7FZ04"/>
    <dbReference type="PaxDb" id="2850-Phatr12533"/>
    <dbReference type="GeneID" id="7201112"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12533"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_0_1_1"/>
    <dbReference type="InParanoid" id="B7FZ04"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="25818" checksum="2BC2F4F2E89D6F2F" modified="2009-02-10" version="1" fragment="single">GVNMDQEAMMESDRLIAVNENDRLVRNVNLSKRNGHTFNKETPRAALHRAFSFFLFDDQDRMLLTQRAGTKITFPNVWTNTCCSHPLYDMTPNEVDVADDAYPMFPGIKHAAVRKCKHELGIAPENLPKEDIQFLTRFHYWAADTVTYGDDTAWGEHEIDYILFLQVNGQVPVDANPDEVSDYKYVSMEEMKDMMEDPDLLWSPWFRGIMNRGGFEWWADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZI6</accession>
    <name>B7FZI6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180357.1">
        <property type="nucleotide sequence ID" value="XM_002180321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZI6"/>
    <dbReference type="PaxDb" id="2850-Phatr46017"/>
    <dbReference type="GeneID" id="7201072"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46017"/>
    <dbReference type="eggNOG" id="ENOG502SQWD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274119_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZI6"/>
    <dbReference type="OrthoDB" id="49290at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="869" mass="95450" checksum="306AFCDA99C4E167" modified="2009-02-10" version="1">MNLVSDDRVDKASLHDALSIGDFGTGVLLEKKTPSSDEARRLPMLLRVLSSSRPLSAVPTFCNTQRSSETVNDSDIDDLLETAVSRLEDRAALYSSAEDVEVVSCHLAPSICRHISRLGPVSSSMEELGLLASTSVGKEHRQRYKSDEDGRDVKNANEDDELAGDLDRQVDEDDRDDKPGSTKRRRLDRGLDPASAEVVEDSQEATVTRTLSELVKLVVRHLKSKDQVSSGEHGLPLPVDDSILSEARNEKHSSMGGDLGSALASLLYYSPGIKYEHVAGALCRAAVPQSAEIILCMAANCPSVAPLLLRGCLDVYRQEATSQHVAIRNTIRSAIRNLASLSSRDSAKVLATLRFQRAMPDMQLELLLKFDRLRASLFLLENLSLLPTLRNADLTGHSARTHISHDGSSLETKQSLICTLREDLELSSRTLTVLCEEIAKVPESLHRSGQTLIVLSAYSLFLARTEIWTLGTASQNGGMAFPGCKDLLDCVAFVSHAKIPSSHSGANNVLDRIFAMEVCAILLTFCHVAGRSESTHDEKLNIGKCLLALLNEALSSSKARRYAPRVVINLKFPNALELQQVIEDMLFSGKTSVPRTFFGSNFLDCVHVACEWASANLELDSLVDTALAPKMESSLLAISCMRNEGVPLEFQLRQARSALTAVLSETREEYVVARDCSASSLIQYASMLLLSNERSKIPLVFQLSLERLASRVDFVKAMESLGATEAAFLSQVLYSLIFSEREPAAAFQFDHRALPLKELYILCETTATDMSCRSVRLQLLDMLDVRYSEIRHQTVAWIVQAGSKRFVELDRDIPTQSSSALARALRAYIIQPSSDPSGHQIQKAFALARRSLLLLPSATQASLGIRCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZQ6</accession>
    <name>B7FZQ6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179988.1">
        <property type="nucleotide sequence ID" value="XM_002179952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr45763"/>
    <dbReference type="GeneID" id="7200905"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45763"/>
    <dbReference type="eggNOG" id="ENOG502STP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761789_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZQ6"/>
    <dbReference type="OrthoDB" id="48773at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852859" evidence="1">
        <location>
            <begin position="29"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="366" mass="39832" checksum="3235E3E734B42A3D" modified="2009-02-10" version="1">MTMMSTRSTLLFLASLLIFDNDKQQATAFTPLTISNGRVGWVASTTRRSATIYSPDGVAHAWDEDDFFYDETGTLNASPPNSPHNVYQESGFGPDLEELDPHKSLKSLISKEAMPELARLAVAFAPPDQALELDEIEHVEVLSVDKDHIQIEVVLCERDGCVTLAIPVSFPSPCGIEDKFSECVIDNIDLLNTVAHEDLAKLDSLKNRHEDVAHDTRTMQILKSTSDLELPSWWEAPGLDRVLADECDNVRNLLNELEFQDDVKCLTEQALANVGGCNEWAVDKAACAMVGPAGLMLRATIVEIDADGNEPRREQVAFPVGFGRSAPTIEALRAAVLGMVAAASSAEASAVAVQANADDEAARLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZX8</accession>
    <name>B7FZX8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180578.1">
        <property type="nucleotide sequence ID" value="XM_002180542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZX8"/>
    <dbReference type="STRING" id="556484.B7FZX8"/>
    <dbReference type="PaxDb" id="2850-Phatr35939"/>
    <dbReference type="GeneID" id="7201311"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35939"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B7FZX8"/>
    <dbReference type="OMA" id="WQSHLAV"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="27902" checksum="638BD9666923DDCF" modified="2009-02-10" version="1">MTPDPYAEKIVLDTGASSGMGKATAIYLAGKGVKAITLFARGKDRLDEVANEIEAMDTATKTLIVVGDASKVSDNQRAIDETVAAFGGINSAFVNAGVYRGELPLADTPDEAIEDVLNVNVKGVIYALRCLIPAISKTVGDDKDMPTGSIVVNSSCMGASVIAPKSNGSSIYSASKAFVNSLVLSAATENAPRIRVNGVMPGVVQTSIMPVDDATYQMLGAAVQPLYGRPGKSVEVASLVSYLISNEASFISGTNIKADGLWSLSGDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G048</accession>
    <name>B7G048_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180615.1">
        <property type="nucleotide sequence ID" value="XM_002180579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G048"/>
    <dbReference type="PaxDb" id="2850-Phatr36009"/>
    <dbReference type="GeneID" id="7201453"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36009"/>
    <dbReference type="HOGENOM" id="CLU_075196_0_0_1"/>
    <dbReference type="InParanoid" id="B7G048"/>
    <dbReference type="OrthoDB" id="4455at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855245" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28830" checksum="ACF508DAB61D7CD3" modified="2009-02-10" version="1">MKFTAPNVALFLLAALQATATSVHATRFCKEHGALIPVTVVSATSPDADGLKDGFEVFRDLLGGENNGNGAAPSAEGHRQVNWDAPIVPFDMPGDFFATTVDRGLNLRSKRDEFRVSNPDPKDGPKDDLFDSISPRAAKDFQTFSAFRLFTVAGGDNEFVAEFTVPGSHKEATVAGFGAVLVDVDLSHKTTLTFYADSGCIIAQEDAKALKDGLSFVGLVSQSEKFPIAKVEVELGNKAIDDTSRFRGFADFVVMDDFLYSEPQELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G163</accession>
    <name>B7G163_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_46427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>acetate(out) + H(+)(out) = acetate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71803"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>formate(in) + H(+)(in) = formate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:80887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180980.1">
        <property type="nucleotide sequence ID" value="XM_002180944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G163"/>
    <dbReference type="SMR" id="B7G163"/>
    <dbReference type="STRING" id="556484.B7G163"/>
    <dbReference type="PaxDb" id="2850-Phatr13076"/>
    <dbReference type="GeneID" id="7201669"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46427"/>
    <dbReference type="eggNOG" id="ENOG502QUGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_1_0_1"/>
    <dbReference type="InParanoid" id="B7G163"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015499">
        <property type="term" value="F:formate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852844" description="Formate/nitrite transporter" evidence="13">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC47632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="32304" checksum="DC684A60D175BD86" modified="2009-02-10" version="1">MLMIIRSALLLCLLAGSSAAFAIEQPKAAVHQAVTMSPGGAISLPPAPVSVLDLKPPAALYEGAVAAGVAKASASFGKIFKLGIVSGCHIGFGAYLAIAVGGACPGLAQTNPGLQKIVMGAFGLPFGLIMTLVTGGELFTGNTALVTAAKMEGKISQKALVKNWTASYVGNFVGSLILAYLAYKSGTLGVAPGATNIALAKCSVAWDVAFVRGILCNWLVCMAVYMASGCSTLIGKMTAVWFPISAFVALGLDHSVANMFIIPLGMLRGADITIAQMFVKNLIPVTLGNIVGGAVAVMAPFGLSYGKWFQNKDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G183</accession>
    <name>B7G183_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_46440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180990.1">
        <property type="nucleotide sequence ID" value="XM_002180954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G183"/>
    <dbReference type="STRING" id="556484.B7G183"/>
    <dbReference type="PaxDb" id="2850-Phatr46440"/>
    <dbReference type="GeneID" id="7201543"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46440"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294493_0_0_1"/>
    <dbReference type="InParanoid" id="B7G183"/>
    <dbReference type="OrthoDB" id="48343at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115239" checksum="38026E80EFDD4BD3" modified="2009-02-10" version="1">MSLPPLSVRKRGVKDPRPYEPTTTQAAEDAVARIMDSLGTAVSPHLGKVNLQKGLYNESSGTSTRYRYERTEESWLERALTTDDDDAMETDELVTGSANSKKPRILERATTPIISNASHRSQDRDEIMSPVPLRSPSPTDDAGITGNDTYLRRTPTTLRTGHVAGPSSRHDALEYGRYHDAVLRFVQVKRRVTERVELKQRSLALQEERTSPRVPFDDAMELVPDDLFIANRDGDALILDETRADVAFLRSLHNLSSDHVNASDARLARKEGNFWLLLSHLRELSLDTLIWADDAASLHQHESSLLAYVDSLAAKVNAAPLELTQALQLNTSECPSLLRRRQCIMRWLEACFHQQLPTGSTRARHATIICDSKLLRQEGLPETDKDAEILKNALALILAGREEDAQILARDSGAPWRAALWSGGKPQGVVHKPNLATETMDRIPTGNPRRALWKRMMWKNAEALHQKGKAAADEAAIAAILSNNLKIALLNPSLRTWEKCLYVAFRCMIGRTEDDLLHKHNNLRRQYRPPFPGTQFAQHELQQLRDTADIAAEDEASVIHNILPSSVFDEVKDDDVVTDATSSFLVGKSSIASYLQDSMADLDDAGEMQLRFLTHLGLYLDSLAVGTTPIFIQGVSDWKNRMLLKYLQYLSTREELWHLLVLYASLLPESVLTSQLPNMLQSLDSQEGRRTIVEQMRELLPRAGLDLVVLQNVVQATLQTTDTENSCVDTPTRLDVQKMRSIAWLSYSQDHTVDALVFSNSLLRHFLLGGRRASAILFVEDFRLESVLELAEGNGEDEAADVDTWRREHMALQYYLDATQAIDHWREIISTVESTTKLIDDRIDIGRLDETDVSVALKIERRALLEEKRKASFSVVRASNSALKALSAVLKYRGGWLLLDYDAASRHCDQNARSAELDALRRKILPHCISSYCEVCMETAVWMSSSMDDAVAQLSESPSAVLDSLDSPQDGEISPIAPFYWPQQALEIANVVASETYGILSAFGTAEKKQLVSDLAEASVANLFYTTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1M7</accession>
    <name>B7G1M7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_20885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181057.1">
        <property type="nucleotide sequence ID" value="XM_002181021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1M7"/>
    <dbReference type="PaxDb" id="2850-Phatr20885"/>
    <dbReference type="GeneID" id="7201844"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20885"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="B7G1M7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855615" description="GST C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="398" mass="44674" checksum="F026777A508FEB01" modified="2009-02-10" version="1">MRLCRVFSLPVFVAWCILDGPRPCTRASAFHIPKVVVSRCIRNSQSATLSSTVLGVKIDKGFNLLELAGGVVPQGNLVKTAKEGWKFIWKRMMAELAPQDETGNYQRPSYKFQGRLGTTEFPDEAGRYHLYLGNPCPWCHRCLLAVNLLNLRDGISLTRLEDNPEKASRGGWIFSATDRDPFGNKDLREVYDQLSPGYRGRCTAPLLVDKKSRSIVSNESSDIVRMLNSVRLGGDPGIQRFNLYPEELTQEIDKTNEWVYDMVNNGVYRCGFATTQAAYDEASSSVREGLAKVEKQLYNRNFLLGDQFSEADLRLLPTMLRFDCAYAPLFRAGGAHLRIRSDYPEIYAWLKRCWGLEGVSSSIDLPDACGSYYRQLFPLNPSGIVPTPVTAASLGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1V8</accession>
    <name>B7G1V8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_54611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181101.1">
        <property type="nucleotide sequence ID" value="XM_002181065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1V8"/>
    <dbReference type="PaxDb" id="2850-Phatr54611"/>
    <dbReference type="GeneID" id="7201742"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54611"/>
    <dbReference type="eggNOG" id="ENOG502SDUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050614_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1V8"/>
    <dbReference type="OrthoDB" id="42904at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852863" evidence="10">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="441" mass="50434" checksum="BFC9E0F5122F1E1F" modified="2009-02-10" version="1">MIPRHRTCRVITTVACCSFLLSLWQLCRSIHLQTDSAISSEAPVPDIRFANAEEMNGWFPPAIEHSERLVLSNIANNKSIASRDPRVAVSLTGNPKILANEFDGIQARAFVVYNNSLPCFHPTDNRTDVHWTNRREIQGTPSRTGLLFLKLLKTGSSTAAGVHLRIARNVAARQQHTDYSVCKTRFLHGQASPSRFDYGARQRHASFLWTLVRDPTDRAASEFFHFEVSRKGVPITDAAFINFLRTSKHMNHHYISWLSTRSYNFRSHNATNFANQIFRDYDFVGVTERFDESLIALMIILRLPLAHILYVAAKSNGGYDDGAWRRRCVWIQPSRLTQGMQAFLASDEWQSFVRPEEALYRAANRSLDLTIDHLGRDLIESNLARFRQAQKMVTERCSPQVRLPCSAEGVRRQENETDCLWQDMGCGFDCLDRVATELRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2N2</accession>
    <name>B7G2N2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_47148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181410.1">
        <property type="nucleotide sequence ID" value="XM_002181374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2N2"/>
    <dbReference type="SMR" id="B7G2N2"/>
    <dbReference type="PaxDb" id="2850-Phatr47148"/>
    <dbReference type="GeneID" id="7202049"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47148"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020909_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2N2"/>
    <dbReference type="OMA" id="MCINIGA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="775" mass="83569" checksum="41DADF879C30CA2A" modified="2009-02-10" version="1">MTTPSESATSPPLSSEHAPLLGTGSVSVATSPLGAPTKLPMPPPPSTTASTNVTTNTTLPATTTTTPTTIATTTNDATTNTATPSPLLAIGTPPTRTRHSPSASPAPQTKRAAAVVPSVPPSRASSRAPSPIGSDASDELPNNVCTEEQLLLLPEECLSGHHVRPLRHVDEEGNESFYHLRPMFYSVIFILLVELLERFSFYGINYTQTSYLTGSYNRDWNADMEAVDASTYVSISVAVAYTSPFLGAYLADAILGDYGSLFVGSLCFYLPGLTLIALTTIPGVLGDTFNRRALSIGLLVLWPVGTGIVKSVVNVFGAKQFHPLLQASMIESYYVKFYMCINIGALVGGVLVPLLAQHNVTLAYFVPVGMLSLGVGLFAVGSKRYVCDQPKDPSATLAANICRRRPPKRPAYTPPNTDSIGLDMIFRISLLIIPFNIAYSQMATTFIVQGTVMEKAFGWIDAACMNNADAVSVLLFGYLIGSQFYPALANRGIRIPTTYKFAIGSGLGALAIAWALLVEVLIHDRFESTGKRVSVLWQTVSYVLIGAGEIFAVSAAYEVAFTAAPPEKKVLASAVNLFCIGGLPNVFCILLYNACRPWFRNNRGTTSITRLEDYASAHVEYYFWLLLAIAVVGIGINLLPAVREFVEAIEEKATDMIKTPKTPSRPPIRERTLDEAENEESALLRTRRHQAYLKYGSAPVLYKQGSMRAGPSLSQRGGKAHKHVKRTLIKKLYRSDPVLPGVGTVITSQGTPVPARFIPPRKNPSLDGLLRATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3J6</accession>
    <name>B7G3J6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181626.1">
        <property type="nucleotide sequence ID" value="XM_002181590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J6"/>
    <dbReference type="PaxDb" id="2850-Phatr47494"/>
    <dbReference type="GeneID" id="7202597"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47494"/>
    <dbReference type="eggNOG" id="ENOG502SUDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569218_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3J6"/>
    <dbReference type="OMA" id="LAICARM"/>
    <dbReference type="OrthoDB" id="46448at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="480" mass="52335" checksum="BA868F65BC9AE1B4" modified="2009-02-10" version="1">MGLFSTLDNQPDQVGNHPSTSSTSLSLPTVVQLYTDEPFRLEQSVAQLPSYAALTYQAVSVLVTDLAETLPVLSVRTETHRGLRHRPPLATEPVPDLGVWSCRVIARTAHHETTHDAATLTDALLRIPHDSNAVFAFTVDLRDPARVEPTLTRLQDALVRYLIHRDEPNNDPHADALPVAPTTTTTTTSLDDLRSVAFGTAPHDDDSVKAVPETKDRTVRVTLAICARMPADDLDTTYTNNSSNNKSNNDPPAKEEAVAGYHAKQTQNLIYYHLRRYAAALNASLIFVDESTSSTTDKGTALTDRQPTVSLPQLAFFLRELARGKALWLELEQSARTNDEDDSNDESNAKAPTPESAHAIVYGPGSHQEDLIESVWLRNAQYPGHWDAAKDPVWKILPPPPLPDPSAIGKRPPPPTGTVGDEAWLTELRDSVATVTDAASKTPPPKNKSGVNPAAGTTPVDKTPNEKDVSNFFESLLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3L6</accession>
    <name>B7G3L6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181635.1">
        <property type="nucleotide sequence ID" value="XM_002181599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3L6"/>
    <dbReference type="PaxDb" id="2850-Phatr47505"/>
    <dbReference type="GeneID" id="7202608"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47505"/>
    <dbReference type="HOGENOM" id="CLU_525299_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3L6"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="510" mass="57218" checksum="2F7F2749D4266518" modified="2009-02-10" version="1">MKRRWTSHGLGYAAVLTALAGLGYHQRVVRWYGRTSIAPTLDFPSIVTTSPTLTHGTDPTRHTFYLLPVPELTTWLVGNFTSEAVHFYNHTINEERAEIWLHRGFERLQHHHGRTEDPDEAHVVIIPAYLHFNAFLLRNLGIADEATHRGRRQRPVEQHDTERKPNSLPWTASLWGPEIIRRVRVHNVSKPHVLAVPTWNPKVSRKIGLPTLVHSLTRNEVNLYALGLERNSFWYHLPTTRILPVPYVVATADHAIATASPALSMTPRTPSTATTPSTRTIFFAGDARPNAGFWSGCHRAQLLFPLVNVTLSTTAATYHMDVRVSSKTLPQRLSQAAYNDRIRTATFCLILCGDTPTSRSLASAMSRGGDPKRDEKDDRNGSIDSGCVPLRIGSRWRGFCDAPCREGWGWNVANRSHLPFGGTIIDWSVLPELDEAAFATDPVGTIHTFLSTTSEAQIAVWQQRIRRHGQAWMYGYGHPVTSNDFGRAVEYVWRSLADALPRVDAYGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G411</accession>
    <name>B7G411_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181834.1">
        <property type="nucleotide sequence ID" value="XM_002181798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G411"/>
    <dbReference type="PaxDb" id="2850-Phatr47538"/>
    <dbReference type="GeneID" id="7202762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47538"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006685_2_3_1"/>
    <dbReference type="InParanoid" id="B7G411"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="236"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="731" mass="85206" checksum="672E1BA549DA497C" modified="2009-02-10" version="1">MDYSLVREDMVLPEVETTPLLQIRFLPQASDELIHLVQSRLAENGIVVLSSHKLMGKSTILRITAKMETLEIQAEKIHLMKETVGSRRRVVDYFRREHRSRFCDLTKPPQRDAQGLFTAAEYALLIRHLLDRVHVLKTGQVSSPLSQLFDTNYRVKYLVDFDDSKEASRGSLAFLTASLRRKLHEHGIQSACLMHVLITYNLVDAVVPVPVPAVNREIFRKTWWPWSRLDLPIELIQDYYGWEIGFYFAWMEFLTRWLFFPGILGLLVYIIRCYRGDTIDTDEYTPFYGLVTFLWAVLFLRFWERHEHRLAYQWGTFSLSQYERQKFFAVRPEFRGYLRKSPVTGEVETYYEPLQRRIKYIGSALVTSVMLAVAFSVMILSLNLQGYIRPKSNPTRWTKNSPHPFFIADLAFVSEPGQVFDALSLRGYIPVVGHVICIFSLNLLYRRIAERLTSWENHETESSHRNSLILKRFLFEAFDCYVALFYLAFYERDVERLRLELIAVFQIDTIRRVLLECVIPILIQRFNAAHHLKRKLNPMQSLLVIPTHDILMDELDKDTYDQFDDYMEIVIQLGYVTLFASAYPLASLISIAANWVEIRSDCFKLTQGCQRPAVFRSSGSGMWKTLASCIIWTSALTNCLIAGFTSDQLVHYLPSFYVHVQEGYTDMGHEKGWLLVFLIFGLERILVLTGLLVYAIVPAVPEDVVDELERRQYIRSQQEAWEHSPENKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G421</accession>
    <name>B7G421_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181840.1">
        <property type="nucleotide sequence ID" value="XM_002181804.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47548"/>
    <dbReference type="GeneID" id="7202621"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47548"/>
    <dbReference type="HOGENOM" id="CLU_256806_0_0_1"/>
    <dbReference type="InParanoid" id="B7G421"/>
    <dbReference type="OMA" id="YENESHC"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151391" checksum="116AF7871CF21C7C" modified="2009-02-10" version="1">MTHRFSRVKRLESSVQFPIVIEDEYIDLTSIDYDNDSDDSGAAGNSAAFVQVKPGKSLMEKKLMEGTNDNFLGTDSLRDVQMMQLDVMPDGEKFDDCFQSGPLVRDNNEKSIVDHMVGVLRSPNGTTEAMQEHGQATRRKKIKTPGGAMYQKAMRFIAGSRKKSHGVINSNPVISCGSELSNTSSCGGDRIYRKAVLARVEKIATMTKSKTRNLSPIRIDGEGGGSNRVHPSSDRDSLEVLLNNLDREGPERSLETETVQAVLSEGMIEGVRRGRCRLEGSFDSNTVAEEDAARNQAHPTPIQSDVLSRHHTTSIIRQEHFESRPEVSLDAPTGQVARKKSRSKQPSQSNQDRNCFSTETEQRFVKPLRRSISPVRTRSPDGAMKVGPKVSPQNRESSAIEAGQAYRDIQPACTRGELLQRDYGSIAKRYQNPVEATQEMTAKIGGSRRNQDFFSMFDDTTEVSEVRSCDNFSTLSNHHNDSFPIVSPKSSEAFFSFELNGISSDLNFQKQILKEQPRSSLRISPNRSLRDRHEPVEGEERDETRQDDPDGRVEPGQPIDIIKIKPSDEHYLAEVIDVSGFSDERRFRRLVTVAEPHSRQQESRSRSPTGKGLRSMDSVSNKLINPKRSALKSSFSRSQSPLKRSVTLNLQGEESLSKTSLVTSSASQKQEQPKNKDLLEVDERVISYSGARREGTQFHGKDFRRSHSFSSQNNTSIEPSECAPTFDKFVSKPNADNEAVRRKFLKSDYSQDCAKRVANNTSSSVSNLYNADEKREKANALCESAPQLYAQYENESHCGPLGQSEPREDPHGEDSVGDDYTTDNTNGSGSEETDSKISNQSLFESEDSDLDDLDVELYDSFAVPFLVRMLDKSFAWLEKSNDQFPCGGGSHSLLKETRKGPEDSKMSVVQPLFGVQEGFSQHNCTDNQNDVTYRSARPSPLTAHTYKSPALNTFLKQEELVKSTKSLTPKISNTTTRRAGPANGQIALTETPQEAYIGRGYTASARDILESNHIYADQSQRKIEFDVGAGAGGQKKIDASECTELSTQCSTKTAVDKSTHASGRSKAKTFAERKAQIVAERNALRAVAIATMRQAEKGANSYSEARNGEKKSAVIKCPTSGVVSRSKPADHPLDPGSVNLPVRSTHMENAKKSRPISPEKQRGSDKSDTEKGECSSRPSYFQEKLKARLAHVRGLDTPELELPAESRNTLESTRFSRDPEDEVPKSQKSDIPIGNVRPDDYRSEKAASLSSAGSNRHRSFAGGPESMVSNSSRSRKSPPGSPQKRLSQKVNFFLKTIREDIAIGGENQNDFYASLTEDERLAALELAEKLRRRAATLKRRRKVRERRNPEATPHLPEMTSSNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4F0</accession>
    <name>B7G4F0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_14230</name>
        <name evidence="12" type="ORF">PHATRDRAFT_28937</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182062.1">
        <property type="nucleotide sequence ID" value="XM_002182026.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182064.1">
        <property type="nucleotide sequence ID" value="XM_002182028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4F0"/>
    <dbReference type="STRING" id="556484.B7G4F0"/>
    <dbReference type="PaxDb" id="2850-Phatr14230"/>
    <dbReference type="GeneID" id="7202846"/>
    <dbReference type="GeneID" id="7202848"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14230"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28937"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_1"/>
    <dbReference type="InParanoid" id="B7G4F0"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="9">
        <location>
            <begin position="75"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="37359" checksum="6256B56FA96B2CC4" modified="2009-02-10" version="1">MASLKPYIEILIQGTRPLTADETEAAFSEILQGADEVQVGSLLTLLRARGETPSEIAGMVRAMNKACNAVDLGNRKLLDIVGTGGDGADTINISTASVVLAAACGCIVAKAGNRSVSSACGSADVLEALGVKVDLTPEQVVKCVDAVRMAFMFAPVNHPSMKYVAPIRKKLGVRTCFNILGPMTNAAGAQHAVIGVFHPELLSLMAGALKEVGRVDHAVVIHGLGLDEISPLGPSTILEIKNIAAPGEPRIYEEREFEFDPLSIGIARCELADLKGGGPEENAQKFRDVLLGGGHTDAKRDSIVLNAGVGCYVFGLAKSIEDGCDLARATLESGKASSLLESWVKVSQEIATAEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5A8</accession>
    <name>B7G5A8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182214.1">
        <property type="nucleotide sequence ID" value="XM_002182178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5A8"/>
    <dbReference type="STRING" id="556484.B7G5A8"/>
    <dbReference type="PaxDb" id="2850-Phatr47899"/>
    <dbReference type="GeneID" id="7203165"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47899"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1380495_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5A8"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="198" mass="22460" checksum="593B0D7804B93C75" modified="2009-02-10" version="1">MAPAAILRSHDFADSDIPLIDIASDEIERMRNPKDDCRRYHSFPPACLALLMSIEGNHRCVDCGEPNPQWAAVRYGGLLCLQCSGVHRSLGVQVSSVRSISMDDWSLEELLSMLEGGNRQLTGFFERHALSVEGCSVNSKTITPENVTRLRYKTKAALFYRKQMELHVQKILDSGPYRGRESSRRNHCHLERRNTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6L5</accession>
    <name>B7G6L5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_38702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
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                <person name="Vyverman W."/>
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                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_002182749.1"/>
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    <dbReference type="AlphaFoldDB" id="B7G6T0"/>
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    <dbReference type="GeneID" id="7203801"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC45521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="441" mass="48783" checksum="21BFFBC6649FDD6A" modified="2009-02-10" version="1">MPSSGLFNNSKTPYLQGPENVGGSHIIPNLCLIYITLSNRSKDCLFALTVNSPCSAYPEFKGLRKRTSSNILQGCSSIIRHAGLDPSLLVHMANIPAEKEFLVGFQPVSPQRKKGVRFLEKRLMQRFGIGPDRARDVMREARGKLRTDHSKAYSKRLEEECVIVILRPNESTRLLDDSFANLSITEACLKMESSLTTEQSKKTPPKPFEATLSDFFVTQYGPLKTKADADDATQQSRQSVRSPKTTQASAPELRGKSREGSVRAGKQRLHDFGKTWSPSSRVEARPSVEARRTKVTGAQAYKSTAAPVFSDQRDTVDQFPSCRSPKHEPALSVAANPSKSYVNSSRLQKAKSYRTFLKPMERGQDSSNSTLSTTSAGGDSSPIKKKSFNRARPCRRGEGALVALRKTLSVTDLFRSFRKPKGSMQSTVMDASDDDDSLYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6X0</accession>
    <name>B7G6X0_PHATC</name>
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        <submittedName>
            <fullName evidence="8">Peroxiredoxin</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_22388</name>
    </gene>
    <organism evidence="8 9">
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            <taxon>Phaeodactylaceae</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182930.1">
        <property type="nucleotide sequence ID" value="XM_002182894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6X0"/>
    <dbReference type="FunCoup" id="B7G6X0">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G6X0"/>
    <dbReference type="PaxDb" id="2850-Phatr22388"/>
    <dbReference type="GeneID" id="7203578"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22388"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_2_0_1"/>
    <dbReference type="InParanoid" id="B7G6X0"/>
    <dbReference type="OMA" id="AFVMFQW"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="233" mass="25915" checksum="EDED006991788E5F" modified="2009-02-10" version="1">MWSYKRVNILTLVAGVALLVASTPILASAATSRVEFPSDWTTPLSEGDRVPEVTFLTRSRVESNDPNPFDWKLRTTDDYFKGKRVVVFAIPGAFTPTCSSTHLPGYEAAYDKIRQQGVDDVYCLSVNDAFVMRQWGLHQGLTEDKTVGGLGFTKVKLIPDGAAAFTRGMGMSTLWDVERGFGERSWRYSMVVNDGVIEKLFVEQPLLQNSGPDPFEVSDADTMLAYLQQKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G753</accession>
    <name>B7G753_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_56578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182845.1">
        <property type="nucleotide sequence ID" value="XM_002182809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G753"/>
    <dbReference type="STRING" id="556484.B7G753"/>
    <dbReference type="PaxDb" id="2850-Phatr14898"/>
    <dbReference type="GeneID" id="7203681"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56578"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G753"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853049" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="21354" checksum="5BC881A80952B294" modified="2009-02-10" version="1">MKLRLLAFVATSLSLCSLTTSFSSIHSSFVSTALFAAPETSTMPEVSVGDTIPDVTLTELSSGEDKPVDVKIVDLIAGKKVAIFGVPGAFTPGCSKSHLPSFMEAQEELKGRGVDMTICVATNDAYTMEAWGRTSGGSDVGIRFLADNSGTLTKELGLVMETPVGIRTKRFSLIAEDGKVTKYFSSAKDSSDTWAPNVLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7A2</accession>
    <name>B7G7A2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_3351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002182836.1"/>
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    <dbReference type="STRING" id="556484.B7G7A2"/>
    <dbReference type="PaxDb" id="2850-Phatr3351"/>
    <dbReference type="GeneID" id="7203703"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3351"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="B7G7A2"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF18">
        <property type="entry name" value="RRNA ADENINE N(6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
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        <ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
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        <location>
            <position position="118"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EEC45608.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7S9</accession>
    <name>B7G7S9_PHATC</name>
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        <recommendedName>
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        </recommendedName>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
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                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002183033.1"/>
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    <dbReference type="STRING" id="556484.B7G7S9"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 18"/>
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        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF6">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853005" description="L domain-like protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="73425" checksum="7BB4F2C79BC2CD7A" modified="2009-02-10" version="1">MRRIGLLSALLLLSAAFAEQGLRRKRNLLDIQVESEIHHEMISPYNELVLDDFLWGGRKLMKVDGKSKSKGTMDSFSAMALKSTKSPKSTKAGLNSPQMTTVGIGSFSPKSKKKSQKTEDCYSDVFGYLFCDSSMSFMSMSVSMSMVATPTMPTNPTTPTTPIAPLTPTAPSTPSTPTTPTAPTTPTSPTAPTAPTSPTAPTAPTSPTAPTTPTIPTVPTQAPIDGCSSLPRDEALRTLVGAITDETTLADSTSPQGQAYQWMLNTDPASLDPCTDDNVLPRYALTTFYFSSSGASWTNSSDWLSGISECAWYGVVCSSTGTVTEIALFENNLAGTLPTELEALTDMQRLDVFDNELGGPIPNILSKWPFLAFFDVEKNQLTGSPFVDAIGLFNLQSYRVSLNAFVGGTIPADLVDKFPNLVELWLSNSTMIGSIPTEIALMDNLQSIFLYGNSLTGTLPSELGQLNLERLQVQDNMFAGRIPTELFRSTNLADLRLDTNKLAGPIPSAVGALTNLIDLRLNNNVLTGTLTTEISRLSNLVFFVLQDNQLTGTFPDAFEPFQALQFVDVSGNNLTGPLPRTVFDVPVIEILYFDDNAFTGTIPGNYANASSLRDLWLNDNQLTGTIPPTRPAELASLEEFRLDGNNLVGTVPLSLCALPSSTALTADCGGPSPAVECVCCTLCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G836</accession>
    <name>B7G836_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TPS2</name>
        <name evidence="3" type="ORF">PHATRDRAFT_48682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183251.1">
        <property type="nucleotide sequence ID" value="XM_002183215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G836"/>
    <dbReference type="STRING" id="556484.B7G836"/>
    <dbReference type="PaxDb" id="2850-Phatr15140"/>
    <dbReference type="GeneID" id="7194914"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48682"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_1_1"/>
    <dbReference type="InParanoid" id="B7G836"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF109">
        <property type="entry name" value="CBM20 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132567" checksum="7CF89D2B6C65D8FA" modified="2009-02-10" version="1">MEDSAELTGRVVRLHFRCKAAVPIGSFLRVTGSTLWAPGTAATDPADAAPAVGRTEQAGFPTSANEEEVTMMPMQSPVSSLYTSSVEMVTTPEEYPVWRTRKPVVLVIHNGKRNTQHHYYRYLVVSPGGGGHMEIGEKEIETDDEEDVAMVSTSNELIGTTTVMQWEDPWGTLRDPRADTNLMSTASLTSSIAGNSTHVTKDNYRNLPYRTLDIDIKSGKPLLKGGMEDAVRLDHWNAPDDDSFQSYVIRKAIMDDKNRKLQPRLSDANDLSRTDSDMGMADAVGPSGVLRPPLTAKSKNPGLASGQATPPSFPSHNRIFFICFHLPVVVVQSQSTGQWRASWSESILAKTEGSQILSTYEAYWVGTVTTSPPLTNEKDKDEVRQILQEMNCIPIILDPEVRQAHYYGFCKQVLWPAFHNIDLLDLSTCGWLSDQESGSSDWDQSRLDSWWNSFVSVNQEFCNVITSLSRPGDIMWIHDYHLSLLAQQLTQAEIGKYGWKMTRKVFFLHIPFPTSQIFRELECGERILQGMLHADVVGFHAFDHARHFLNAAKRILGLNYESLAGGLIGVSFQGSTVLVTMSNVSIEPRMVDAALMLPSVQQGKDEWQKKHHGRTIIGGLDIGQRLSGVSLKLLAYERLLQDYPSWVNSVVMIQLVLVPGSRKADEAVTTSELRSLVKRIQDKFGPEVIDYVELAGSSIPMDRRLAMWKASDILMSTPIREGLNHWPMEYIHAHKEPEVPGVVITSEFSAISSILNGALRVNPFDIQMTVSTIDKALSMGQEEREGRRYRDIDFVSTSPSDKWVKNVLRDLRDATLRQQSVGSESNSQASTPHGGMTPIRRDAVDSTASFLARESSSVFTPLNFSALKKAYLATKRRVIITDFNGTIVLKEPPGTSGNKPPQEVIEALSTLCEDPRNLVYVVSGDSSENVLNALGHLPNLGLAVSNGARFSPPLAPGESTRRWMTFDLGVDWDDVKRTALPVLAKYTARSNGSFVKLTSLSIGWSYYSCDPEWGSLQAAHLVLELERELRAYDVRFVTLKGIVEIVPRKLNKGLIVRKILRDTTVAHPEGVDFCLCFGDDISDEKMFTSVFSFLAEWGQEDESAVKPGPTVIGDDGTVESAVEAERDSSQDGGTPMQVSNDNGLMYAFTVAVGKKQTHASSYVNDAQEVANALVMLAEGDVPTGGVPVWGRANSSDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G846</accession>
    <name>B7G846_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183275.1">
        <property type="nucleotide sequence ID" value="XM_002183239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G846"/>
    <dbReference type="PaxDb" id="2850-Phatr48715"/>
    <dbReference type="GeneID" id="7195187"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48715"/>
    <dbReference type="HOGENOM" id="CLU_542361_0_0_1"/>
    <dbReference type="InParanoid" id="B7G846"/>
    <dbReference type="OrthoDB" id="47615at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="503" mass="56363" checksum="537F33C650119C6B" modified="2009-02-10" version="1">MKRRPVVRCIAMAVAVVTVGIHFLLRGILFLPNIANLRRPYGTAAISGVGYHFNDSEFASNAYKDHFRSRLDSLLSATNYTEIITWQGVGQMDHFLSSFWSGNYGCDVLRTSLGRSETKQGPILLNISFGCDDLFRQSHLGSGNFLTGLYGLRIAARALGNADLLITCPDAIDQKSQLLLPHVMGFFPEATHPVPAHDPSRRSVSVSKACSNANFSPMGYLLNEMQHEWRTMAIRMVGIPYPDHPSGAWARIHLWNTTTNDSTKYRSIRQLPVVESTDVPLYPSVELDESVIHFRCGDLMASNHPGFGFMKFHDYARHLFVNTSSIGIVTQSFNANATQQRNIDSGKGERCRLVVDALVDFLQERFPEARIRVHNDIRETMALTYARIVMAHQSVVAISTFGVFAAVASFGTAYIRKPETTGFLARKLPNKWLVYGAGYITNDTSIHLFDAPLRINAKDIRLLWKQRGGDAVVEWFRNETLGGSYPCSTDPRIEHRKLCLPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7G888</accession>
    <name>B7G888_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_29824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183300.1">
        <property type="nucleotide sequence ID" value="XM_002183264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G888"/>
    <dbReference type="FunCoup" id="B7G888">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G888"/>
    <dbReference type="PaxDb" id="2850-Phatr29824"/>
    <dbReference type="GeneID" id="7195006"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29824"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="InParanoid" id="B7G888"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000038">
        <property type="entry name" value="Isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000133">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="17"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="709"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132728" checksum="0703DE765B5D845A" modified="2009-02-10" version="1">MSALPPNLDFAATEVEICAKWKQESTFQTQDKLSLDRGDEEFTFYDGPPFATGLPHYGHILAGTIKDTVTRYAAMSGKHVSRRAGWDCHGLPVEYEIDQKLNITHRDQVLEMGIDKYNATCRSIVTRYTAEWESTVTRLGRWIDFENDYKTMDPSFMESVWWVFRQLFDKNLVYQGYKVMPYSTACTTPLSNFEAGLNYKDVKDPAVVVSFPILGEPQEVSFVAWTTTPWTLPSNLALCVNPAMEYVQILDKATNHSFILAKSRLAQLYPIMNNKKKWKPEKAAELYELQATMPGTALVGKRYQPLFDFFQGEPGSENYWQVVSDSYVTDDAGTGVVHQAPAFGEDDYRVCLAHGIIAKGGEVPCPVDADGNFVDLIAPVKGMHVKAADEILIQLVKDSGRLVQKDVLLHSYPFCWRSDTPLIYKAVPSWFVKVEEIRDRIVENNKQTHWVPKEVKEGRFHNWLSDARDWAVSRNRFWGTPIPIWANDDLSEVVCIGSVDELAELSGVRVEDLHRETVDQITIPSQKTPGGVLRRVDEVFDCWFESGSMPYAQSHYPFENKEGWEKGFPADFIAEGLDQTRGWFYTLMVLSTALFDKPAFKNNIVNGMVLASDGQKMSKRKKNYPDPNIVISKYGADALRMYLVNSPVVRAESLKFKEEGVLGVVKEVFLPLYNAFRFFLQNIERWELEGSSKFVPDLDKVRQTANPTDIWIQAETQGLIKFVHEEMGAYRLYTVMPALVSFGTQLTNWYVRLNRDRLKGAEGEGQEADIEAETGLQVLYDVLLNVSMIMAPFTPFITEFFYQHLRKFQPSYLDATNGGGTSNPPMPGKSDSVHFLRLPTYDETRLNKQVVEAMEALQSVVEQGRNAREKRNINLRTPIKTIVAILRNPADYVVAGITGPLKRYILSELNVWDFKVVPAEEEHDWVTLALTPDFKVLGKKLGSKMKAVSAAVKGLSHEQAVKCLEDGKLEIERVALDTATELVSKLTFSREGEHWEATEKPDGSLVVAIDCTQDEAILSAGRSRELMNAIQQLRKNAGLDLKDVVETFFREEEGVTLVEETVARNVPLFEAKFKGAVPLPYRFVPKWAVVLKNETVDVGGTKVDVFIFRPAVAVKESLGPSVESVLSTLEPSSLPKGGKFSFSLDGVSTTLTEGTDFWLSTTDKVRYTKVLAWLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L7</accession>
    <name>B7G8L7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_7910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183364.1">
        <property type="nucleotide sequence ID" value="XM_002183328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L7"/>
    <dbReference type="STRING" id="556484.B7G8L7"/>
    <dbReference type="PaxDb" id="2850-Phatr7910"/>
    <dbReference type="GeneID" id="7194942"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7910"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328040_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8L7"/>
    <dbReference type="OrthoDB" id="36727at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="70" mass="7633" checksum="7838C16B007A69FB" modified="2009-02-10" version="1" fragment="single">LDNVVQSRRFGDAAYHEALVHPSLFLHPNPKRVAILGGGEGATLREILKHDTIEEVVMVEIDSGIVAVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9B2</accession>
    <name>B7G9B2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_52498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183605.1">
        <property type="nucleotide sequence ID" value="XM_002183569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9B2"/>
    <dbReference type="PaxDb" id="2850-Phatr52498"/>
    <dbReference type="GeneID" id="7195296"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52498"/>
    <dbReference type="HOGENOM" id="CLU_795609_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9B2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853038" evidence="3">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="360" mass="38525" checksum="3DEBA880BAD7CCA9" modified="2009-02-10" version="1" fragment="single">MIPPATSMAFFAFVLLPSYGAYYASAEVVKFGACMNEPTGQYSTYCDDAELWQAPWQLDDVQGRIVCGCQDAHVGACFPSHGHLSVCRAEAAACPSGEGFSDLARFYNDGKTCMCHGLGEHPYSDIVLEFEETKYGACVIDASTTRCVMHSYMCEAGQSWLPPDILSTRRSEECFCHEVRTGACSHPLGSICAVDADSCQEDSTFLSPAETVAQGLDCRLCAPADVQLTQAGGVDQDAPAPTPTLGNPPTPPSNPYEDFSPHSAPQDTITGSTNENLSSSSSSGMGIRKPAFVALTVLAVLSVLANVVLFRKLRRRNQDKREATGPVTKEEVEKDSAASNIPMVTVDVEKARASMGFNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9S1</accession>
    <name>B7G9S1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_49186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183939.1">
        <property type="nucleotide sequence ID" value="XM_002183903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9S1"/>
    <dbReference type="STRING" id="556484.B7G9S1"/>
    <dbReference type="PaxDb" id="2850-Phatr49186"/>
    <dbReference type="GeneID" id="7195631"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49186"/>
    <dbReference type="eggNOG" id="ENOG502RRCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1499128_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9S1"/>
    <dbReference type="OMA" id="WDNDYAR"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="180" mass="19832" checksum="04223EE1780757CD" modified="2009-02-10" version="1">MSIAEWDNEYARLARSASQMRTKGIAISASDARTLQSGLQRLEVSLDNLPLAAGEIQRRKRLVQHLQQTSLPNGKNSGSGGQQQSQMSMAMQQQDAMIDELAVGVGRLKNQTVNIHDEARLHVNLLNGMETNLDEAHAGLEDETRRAARLREDQSVWRLQLIVAGLSVLLVLLIVMGLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA86</accession>
    <name>B7GA86_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_2542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183903.1">
        <property type="nucleotide sequence ID" value="XM_002183867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA86"/>
    <dbReference type="FunCoup" id="B7GA86">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GA86"/>
    <dbReference type="PaxDb" id="2850-Phatr2542"/>
    <dbReference type="GeneID" id="7195491"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2542"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="InParanoid" id="B7GA86"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="417" mass="46999" checksum="9E5BF453FBD6357B" modified="2009-02-10" version="1" fragment="single">LQRYHKLVQEKDVQTDPHQLYALEALERLRKDLLETEPSHSLPSLTNSETKPSLLATGGFLSSWLGGTNATPSTNKHMHKAQKAIQQAMTGIPHPRGVYLHGGVGCGKTFLMNLFYDSIVEGPWAEHKQKIHFHKFMLRIHQDMHASRYDALGKATQQADLILPSVVAKTLEKGRLLCLDEFQVTDVADALILQRLFTGLWQHGCVVVATSNRPPDGLYWNGIQRDRFLPFIDLLKLENDVVTMDDSGTDYRLVQKAESGATTQVSFVGKTGKMELDGLFYQLTAGSPVTPTSLQTQGRKVKIPQAALKKGIARFSFEDLCQKALGAADYLIIGKHFHTVFVDRIPVLTLNELNWVRRFITFVDSMYESDVKLILHGKTIPSEIFQKPSHEDNSHDEVFAFDRTVSRLEEMASRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAC8</accession>
    <name>B7GAC8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">shikimate kinase</fullName>
            <ecNumber evidence="3">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_49363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184173.1">
        <property type="nucleotide sequence ID" value="XM_002184137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAC8"/>
    <dbReference type="STRING" id="556484.B7GAC8"/>
    <dbReference type="PaxDb" id="2850-Phatr6807"/>
    <dbReference type="GeneID" id="7195880"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49363"/>
    <dbReference type="eggNOG" id="ENOG502QTKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006336_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAC8"/>
    <dbReference type="OMA" id="CEPEVIM"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21087">
        <property type="entry name" value="SHIKIMATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21087:SF16">
        <property type="entry name" value="SHIKIMATE KINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855948" description="shikimate kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="277" mass="30638" checksum="4C20FE27B47D3F30" modified="2009-02-10" version="1">MLTIQSFLIALACTSACFYTHVSAFAPLTLGRAPAFVLSAGGFEWEDPSEAFDQGVENPFKSEVLVGSDEKIKSSAGRLLGPRLNGSNVYFVGIMGSGKSAVGDILARRMGTYNFLDTDEIIERATGMTIPEIFKAEGEEGFRTVEAQVLDSVHPYVRCIISTGGGIVIKLENWSKLQTGLVVWLDCEPEVIMRRIEGTDRPLLQTDNPLQKLKDLLAEREDKYSQADIRIKVTEDMDTEHVADLAIRELHNFIDENPPAWKLAKSKAQAEGLDWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB13</accession>
    <name>B7GB13_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_49558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184384.1">
        <property type="nucleotide sequence ID" value="XM_002184348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB13"/>
    <dbReference type="STRING" id="556484.B7GB13"/>
    <dbReference type="PaxDb" id="2850-Phatr49558"/>
    <dbReference type="GeneID" id="7198185"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49558"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430532_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB13"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="97"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="833"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="958"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124632" checksum="BFF413313A1CE6E3" modified="2009-02-10" version="1">MPHVPFNETQQINPNILNPVRLQQNHSQFASADTAEREGFSNSSNQQKAPLGRHRTQVVHDYHDHYRDPGNFERPAAAGKYPSKEVGSGRPSFRGGTSIHFPERLFEMLDREDELELAHIVSWQPHGRSFLVHRTADFVATVLPRFFRQSKFTSFQRQLNLYGFTRLSVGRDNGSYYHELFLRGCPKLCRRIIRRRVKGNGVKPTPSPRTEPDFYNMEWCDQNGPKKQADSDEDETSLPIAAALAPLLDEGYENLRHQALRQQQNDQSQQQASFSRQQEADSFLYNRRGQSGLRLSSGRKPNFHHQFVSESSFQPVCRSLSRDQKNEHPLTRDCFVPHAVLASRISFRPPKRAKVRGVGNPEVFGSITDLFSSDDDECNEKGIMGATASRSEHVHKAARKVSQEPENDPVSQLPLDPSKDFFDHVHSYLELRQRLDETAKAIDPDGALKALTVDALLGRRDHVDGTFPVEFQQQSAYGETVADTEELLVAASLVQAEFRDFLKRIQKDMPWLAEEDLRGKQSNSCNFDKNTDPSTRIWLAPMKDAQRIVDKASLKYADRYPGPPESWVYDVIRASVVCMNATEIKDVVAWLSSNSHSTPLVAAKNRFQSPTSITKYRDFVFLIKLPVANASFHHVCELQVHHAAMVQYQSQSQHYYKNLRSYFSHVIDVDDWEQRMADLEAIGRYSKYDTMDDGLCTKVSACGNVFRIERLADLLETSLPPCTDAAVRLYQKALVLVISDSNMKSLAVATVYEKLGGALSRRGKYGAALCLLEAAFELRQTDLGETHPDTLKLQNEVGVCHHRNGKYQMALATFKTALETLELQAGKRHTHTAQAHNDIGCLLRDMGKYTEALDHHQQALQIREAVLGKKHTATASSYDNIGVVMQENGDFEWALQYHRRAFIVRRALLGDHPYTAVSYENIGLLLNRQGKSLRALTLLGRALEIREAFLGDRHPDTARSLNSVGLVLAKLGRTPEALSFYQKALTIREDLLGNDHPETGVSYSSVGTALRQLGNYNEALEYHEKALVVASAANGTHLQTAVFHCNLGTAEAHLGNYDTALKQYHQAKAIRTQVLGQSHPDTLAAQRSVDAILRAKVQAWGRYNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB70</accession>
    <name>B7GB70_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184316.1">
        <property type="nucleotide sequence ID" value="XM_002184280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB70"/>
    <dbReference type="PaxDb" id="2850-Phatr49605"/>
    <dbReference type="GeneID" id="7198216"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49605"/>
    <dbReference type="HOGENOM" id="CLU_438379_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB70"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="624" mass="70038" checksum="A23FD9275A0CF295" modified="2009-02-10" version="1">MISVETTQSGAPTAEWAVEKDEPRSANWDPASFEEQLQNSGSASSWKHDSKNRNKQSRLQDISFEFDSAVDKEQPWPFDSSPCAWRAKVPNTNEKINQQLYDLTFVARNNCDKKVDDMYEKTHVCPKEICGFSPCSDSSTSSSDKSGGHSFCGDIDDASGFHSRNTCASSSRRSQRSDHLLKLASGPHRREQSYYQTLAWNRRTESMDSNDALDCNFEYSPPTKPSGSRTHKRSGSETNVRKRIDKSNQNGQDPLAASCHGQIETKIRKNVRRKTTRDKDALSATCHGQIEQIEQTVSKVRRSSRRPKRREEDDPVAMPGEQIQPVQTIRNDNVALSTSSAKGQSEYGADLGGASVHGTVSISRVRSNTQTRCIDPLRNASKRKEIKVKADHQGQKSRGMPTVHNQCSEESSHGRNVDNKELNISRSSGRHKMRQERSSLQPSAAQHQKPVSSRILSNSRSSRHLIRSGSSKSMDDSSSRIRSGPQSASRSTSFLEPKDTQVNQSSDRIETDSDEEFAIDGLGSRTKDISMDRLGSARSMLRRRPNIIGPRRDLLVLLKEKKAFSKNDFMNKENRRLLHFITYERQMGVSMKALHRTIKKEMAETCSDLGKRGVPIEKVVSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB99</accession>
    <name>B7GB99_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184331.1">
        <property type="nucleotide sequence ID" value="XM_002184295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB99"/>
    <dbReference type="PaxDb" id="2850-Phatr40381"/>
    <dbReference type="GeneID" id="7198287"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40381"/>
    <dbReference type="HOGENOM" id="CLU_1707712_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB99"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="154" mass="17634" checksum="D2076F0B0DDF6D58" modified="2009-02-10" version="1">MMRGIDIAVIEGPEMVSTRAGDGGNPPELYQMKQYYPGAPGLPENQTLKLLRMSFPGMGVWESYFLPVSEFVPGDVSCRVKPILTMNERMVDPGLISFSPQSVRAWQYNSVSDGLWNPDGKSMKDWYKSMREKGAELVKRYYRFQPQLFERPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBF8</accession>
    <name>B7GBF8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_40441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184457.1">
        <property type="nucleotide sequence ID" value="XM_002184421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBF8"/>
    <dbReference type="PaxDb" id="2850-Phatr40441"/>
    <dbReference type="GeneID" id="7198163"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40441"/>
    <dbReference type="eggNOG" id="ENOG502SYES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1528105_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBF8"/>
    <dbReference type="OrthoDB" id="39366at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="176" mass="19951" checksum="86F1A080D97E6B0D" modified="2009-02-10" version="1">MSQTPESSTPPTPLASPSTPRWTRHLPEAFGIRRAVEASKYRWCVREAALWGIATGTATSLHRLRMRSTTTWAINTGFGAFLVVYVGSYVFCVQRRDYRERMISLMMQLNSFEHAISMPEPTPVDEHHPFVAPAGTEPDATTIPAERQYIANLPERKEWQPPLPTRDAQDVFQPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBG1</accession>
    <name>B7GBG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyruvate carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PYC1</name>
        <name evidence="17" type="ORF">PHATRDRAFT_30519</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184364.1">
        <property type="nucleotide sequence ID" value="XM_002184328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBG1"/>
    <dbReference type="STRING" id="556484.B7GBG1"/>
    <dbReference type="PaxDb" id="2850-Phatr30519"/>
    <dbReference type="GeneID" id="7198165"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30519"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_1"/>
    <dbReference type="InParanoid" id="B7GBG1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="89"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="205"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="625"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1181"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1252" mass="136068" checksum="CF574D3F989B8D87" modified="2009-02-10" version="1">MYRTRVLRRATATTRTRGAGSGSLSPSRFRLSRWSTTFAAPPLACGLLSCAAGLSQQCHQPIGRGLHTFHTPDEQLPKSGGPVGVDTPPFTKLLAANRGEIATRINRAAAELGISTAGIYSYEDRFTQHRYKCDQAFELDTSKSPVAQYLDIDKIVDICVKNKVQAVHPGYGFLSENETFAKKLDNAGIIFVGPTVQNLQAFGDKTAARNMAIACNVPVVAGSHDAFATAKEASAWINDPANQCDYPVIVKALMGGGGRGIRIVPTEKDLNAMFQQASNEAASAFGDGRCFVEKYVEKPRHVEVQCLGDGTGNVIHLWDRDCSVQRRHQKVVELAPAEGLSEDGRNQILNDAVRLLQNANYRNAGTVEFLVDKNGKHYFMEVNPRVQVEHTVTEEITGVDIVQSQILIASGKTLPELNLTQESIPSPMGVAMQCRVTTEDPAQDFRPDTGTINVFRMPAGMGIRLDDGPGFPGARITPHYDSLLVKITAKARNRKEAAAKLIRALKEFRVRGVKTNKSFLLNVLKHPDFLEGVVDTGFIAANPHLLAPLREQDRAQKLLYYIANVVVNGTPKELGATGAPPSTVDPIIPVVEPNSGQQKKPSLKKIFDADGPDAFAKAVRNNKGLLITDTTWRDAHQSLLATRLRTKDMLNIAPATTVALANAYSLECWGGATFDVSLRFLRECPWERLSALREAVPDIPFQMLLRGANAVGYTSYPDNVVYEFCQMAKDTGMDVFRIFDSVNYIENMKLGIDAVGAAGGIVEAAVCYTGDVSNPNRGMYNLEYYLGFVRQLHGLGIHVLAIKDMAGLLKPEAGTMLVNAIRQEFPDLPIHVHTHDTAGTGVASMLACAKAGADAVDAAADAMSGTTSQPSLGALVASTQGTQWDTGLDLNQVQAVNDYWEEARGLYAPFESGQKTGSSDVYEHEMPGGQYTNLLFQSSQLGLTGQWSKVKKAYAAANRLLGDIIKVTPSSKVTGDLAQFLVANDLTEKEVIEKAETLSFPKSVVEYFQGYLGIPPFGFPEPLRTKVLKGQTIEGYEGLTCFEGRPGADLKPMDMEAVRSKLEEKWGGQADHGVRNVDILSHAMYPAVFDEYKEFKNVFGKLDFLDTRTFLTGMRVNQELRVEIEPGKQLVIKLDSVSEPDKDGLVTLQFELNGTLRTVQIQDKSVDSEKAVRPKAMAAVAGSVGAPMPGVVVETKVKKGDVVEQGDPLLSLSAMKMETTVSAPVSGTVVFFEVTAGDQVEAGDLLVEIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBH7</accession>
    <name>B7GBH7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_40461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184466.1">
        <property type="nucleotide sequence ID" value="XM_002184430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBH7"/>
    <dbReference type="PaxDb" id="2850-Phatr40461"/>
    <dbReference type="GeneID" id="7198173"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40461"/>
    <dbReference type="eggNOG" id="ENOG502SASW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067241_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBH7"/>
    <dbReference type="OMA" id="TIWACNH"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF64">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="38483" checksum="E71490500794A078" modified="2009-02-10" version="1">MPLPEYSTFTVALPASTANAVTELPTTDASATARTVAQTGLPAWKAALTKYTMMMFILGMCVSLPLTLWPQKLLYKLKLINRVRKERWALATGQGCARWMLRIFPFCSLDAQGYHDPNPQPTIWACNHTSMLDVFLLLAADRALRGPHKRPIKIVYWRGLETNPVTRLLFRQAGFIAVNMADNGNGTANEYDRASFKTFLRETKQAFVDGFDIGILPEGQLNPTPEKGLLPVFSGAYTIAKLSKRPMSLMALHGAHRLWHPDDAIGMTVTGRNVSVRSYPGTRVYTSADEFVQTFQHVVGHFGTYGVDLPRPKLRSWLNGSAYAQLQQQLQDGDQQSPQSPAVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBM3</accession>
    <name>B7GBM3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184473.1">
        <property type="nucleotide sequence ID" value="XM_002184437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBM3"/>
    <dbReference type="PaxDb" id="2850-Phatr40475"/>
    <dbReference type="GeneID" id="7198393"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40475"/>
    <dbReference type="HOGENOM" id="CLU_1942188_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBM3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855680" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="13468" checksum="6B6B6E90C3996E18" modified="2009-02-10" version="1">MFIFMFFLSFLGPLFGKDTLTGAEVFATDGVVVGGTTGMRDGAVFKEGAVEATTDGTLEGKPDGELSKEGVIEATTEGIVEGKLDGESLKEGVNEATTEGFLDGKLEGESLKEGDALPMGGTAKTVRPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBP7</accession>
    <name>B7GBP7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="Medlin L.K."/>
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                <person name="Oudot-Le Secq M.P."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vyverman W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CCAP 1055/1</strain>
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                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
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        <property type="component" value="Chromosome 24"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C365.16-ike"/>
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        <property type="entry name" value="SEQUENCE ORPHAN"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    </evidence>
    <sequence length="381" mass="42269" checksum="E12BFB130F1E8953" modified="2009-02-10" version="1">MIDPTFPFPSYPRALPTKRDAPVLTLADSSDFLSVGPIVPFHEYLPQKTRQFAVTWPNQTTIRHPKVSMPLNLGEKLLGDFLVAIGVTACVSPFLTIIDKAMVQRSANSHTLLQSATESATAMSRHPFAFVKSPTFLWMWMTYASTYTAVNMIRTLTEHQDYQFVRDHYRNNSDAISSAAPAKPNTNTVVFLGTTAVNTSASLIRDRAYAKMFGNAAATSVPRVSYGLWMARDFTVIGSSFVLPEYVASFLQHRSNLNEADALNVAQLATPLAAQAIAAPLHFVGLDCYNRALSHLPVVPRLVERGRFLAKGFVEVTAAKMIRILPGYGIAGVYNRQFRNQWRDNLIRRQIIKNTANRQTSSISQDGVRNLVALIRSKSST</sequence>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
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    <reference evidence="3 4" key="1">
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002184613.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr49860"/>
    <dbReference type="GeneID" id="7198583"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49860"/>
    <dbReference type="eggNOG" id="ENOG502SKT1">
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    <dbReference type="InParanoid" id="B7GC38"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
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    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="232"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="501"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
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                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
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                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Lipid-anchor</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="DnaJ"/>
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        <property type="entry name" value="DnaJ domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
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    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
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    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856014" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="240"/>
            <end position="258"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="344"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="709" mass="78156" checksum="8981B219FB5B71EC" modified="2009-02-10" version="1">MSLSTLLLLHVFPALLPPKDGDEWEYYAVLGFDDPRRVSIDDIRKAYRKKSLELHPDKVAQRRQQNAAEAAAEYEKVQEAYGVLGDEKHRQQYAVLGNSPARYRFVHTGGLYNPARLYENLAKASTIDKTRLVVVVSIVFMILLLQPILVAAKVNQVIEQEGTLQNTDWVVILIPTWMLYGLLLIFWVAMAILAPNKAKPQVIATLLTSVCFLSGLIILAKKWDEPLSTNKHWHRASVPFYLAIFCRVLSAYLVVAAAQDEFQKMVSLQHLETTEACCLEDMSEERRAQVLKDNHVITVDEEAVAAALEILAKEGVEFTDDDVEAIRVTTSPEFEAMDAMTQAVVTPAGNMLVFGVTFIALVAAKVEGQIDASWWLVFLPIWILLCQDVARGLFSCCCGSVSGEEVVVMGRSDENSAEKEKGENDTDIEVGHLPVSTGMAAMQSSMEWATAEGDMKDFHSPTSAPVEPLDIGEAGNKEIPSDEEASQTDQLGSKNETFLRQNPHGAPANNLTVEHSEEEQDTEGSNLAPAEQVDKDTSENAEEPEIEFDEDTFRAWQQAQTEADQSAMDAQAKAQGQCCVSLFQVIVVCLIVGKLENDFESDTQDPSDTGYSAFWILFPIFLIAGLMFCCCSCLIYTAGATGLDELVDKAKRKDDEEPNEASASSNVVPTPPPSHAHEPVKSDDLDTTPVSKVNEHNAEASNENMNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCK1</accession>
    <name>B7GCK1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002184850.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr40842"/>
    <dbReference type="GeneID" id="7198700"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40842"/>
    <dbReference type="HOGENOM" id="CLU_1513430_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCK1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="19523" checksum="977C80B05AAF1DD9" modified="2009-02-10" version="1">MTKRKIPQHRTFGDHSFWDTHCQSYPVFRRRDAVPDPVRLSSDSAIGVTDSVVANTVPVNPYRRIRPESIPAQRRAGDGSSDSCTSPEHRREPSQNKTQAVNARLSKASLSRTGRSAPTSIPPSAESRDTGMKVPFPGTAYPSEQSSPTQSVQALFVHSESIPSNSSPRLLHSNGPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCS6</accession>
    <name>B7GCS6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_50059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184850.1">
        <property type="nucleotide sequence ID" value="XM_002184814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCS6"/>
    <dbReference type="PaxDb" id="2850-Phatr50059"/>
    <dbReference type="GeneID" id="7198749"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50059"/>
    <dbReference type="eggNOG" id="KOG4281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807681_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCS6"/>
    <dbReference type="OMA" id="PPYDESH"/>
    <dbReference type="OrthoDB" id="271433at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="344" mass="38112" checksum="B33EB4803FB8D0A4" modified="2009-02-10" version="1">MTNAAGPVVSSQELAKLEGKLNSCIALDLPTDSEDFSTLYSADAHRLSWSIPALIAHRHADGGLASIPSQTLRTTLQPVLDGLGDIDAVSLLRLRLTDQDGAVVGGGLLPIARYRRQVEPIHRQITPPSDDNTVRYLHLSEIPGQYSMGIFVFPPYARIPLHDHPGMCVLSRVLYGSLHRRSLDLALEDEENNDGSNSPTSATSHKNSSWISSHFMWRNKHATETTPSYPWGSKRAFEHRVDILTAPDTTILYPHEGNLHEFAAGPQGAAVLDILLPPYDESHHRDCTFYEIRYDAFSQQEQSSSKDAHKEGRPCWIIPTCQPEDFHCTSGAYRELGEEPPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD56</accession>
    <name>B7GD56_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_50162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185071.1">
        <property type="nucleotide sequence ID" value="XM_002185035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD56"/>
    <dbReference type="PaxDb" id="2850-Phatr50162"/>
    <dbReference type="GeneID" id="7198943"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50162"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510456_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD56"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856108" evidence="6">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="76"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="339"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="54491" checksum="86E72D4F38D0C4E2" modified="2009-02-10" version="1">MAMVWILVHLASPPSLSTDLPHSDERIRRVISTKRDGGHFTVFSLADSEDSTAASSSSGRSELNSRLNVGRVLLRNVQSGLRSTFLPSGYPARTPPGYLRYSVWSWVQDLSTQLRSVLATQRVLEGVGVGREGATALSALLNFLVRDGCGMAASLAFTSAAASRFQSDVKRWRIFADVMVDIGITLEVAASACPPTLFLPMISLGNACKAMCGVAAGACGGAINLHWAKGSDISDIQAKFGAQHTVTGSLGLVFAAFFAKSVSTVPGGRLWILYAALTALHVMANLRCMRIIHFDVFNTTRLRLVLRALFESGTLSNKTAVTTAENGSVFENPPFPKTMPTPSEIAQIEPLLFLPQPASVPIYFGVSFDRFAKLSGKPRAELEDSLLYREHESYIISSAASSSLISMGNGRRCVVVALSSECTPIVQIQAYYHAFLLARLLSHLKPFERNGPREDSDRAESAARQQVQEYWKSFVDAAHHKGWDLTKTQLRTQGYEIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDM3</accession>
    <name>B7GDM3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185238.1">
        <property type="nucleotide sequence ID" value="XM_002185202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDM3"/>
    <dbReference type="STRING" id="556484.B7GDM3"/>
    <dbReference type="ESTHER" id="phatc-b7gdm3">
        <property type="family name" value="Duf_1350"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr41220"/>
    <dbReference type="GeneID" id="7199051"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41220"/>
    <dbReference type="eggNOG" id="ENOG502SKPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742859_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDM3"/>
    <dbReference type="OrthoDB" id="3980at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010765">
        <property type="entry name" value="DUF1350"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127">
        <property type="entry name" value="OS04G0405600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127:SF1">
        <property type="entry name" value="OS04G0405600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07082">
        <property type="entry name" value="DUF1350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856124" evidence="2">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="420" mass="46038" checksum="942BA7D4F8B9F62B" modified="2009-02-10" version="1">MRLRCVYVCSSLLALGSSFSGASFIGSLQATKEISRHPFKYTKTFLPMVGGGGLSDGAGSELTNTLARLDQQWKIQQKSKPTSRWSKIILDRDTQEVSEEPPETYVPPLQERQDFVYLLEPPSKSNPSCVIFFVGGAGLGQFPQIAYNEFLLRLSDRLNAAVIAAPYAVGLDHFGLAKSVGELMRKAKLHCEEDSSKLYPKTLPTYCIAHSLGCKLSSIYMAATEQTYDGIGFMSFNNFGFSQTIGMAKTFADQLQKNIGIGRGIRPEVLDQVFSFAEMAVGSIGLDFTPNPMETERLLTLKYDEEQQERTRLFVFDDDMLDSTQNFVQACNGAGPDVSGLPGSHLTPVYFKLGLDELPDEVRGVAKEASGGLESASFGNEEELNALVTEVSGWILGKGPSRKPLWQTERPTISGSAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE24</accession>
    <name>B7GE24_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_24069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185362.1">
        <property type="nucleotide sequence ID" value="XM_002185326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE24"/>
    <dbReference type="STRING" id="556484.B7GE24"/>
    <dbReference type="PaxDb" id="2850-Phatr24069"/>
    <dbReference type="GeneID" id="7199224"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24069"/>
    <dbReference type="eggNOG" id="ENOG502QQV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_0_1_1"/>
    <dbReference type="InParanoid" id="B7GE24"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21819" checksum="21377008373D8A1D" modified="2009-02-10" version="1">MTFLGKVPFVTNDTFIAPSASVIGDVTNWDQSSVWYKAVVRADSEHSITIGFCSSVGEGTVVNTLSSTGQLETGLPPDTYIGHYVTVGAGCVLKSCRVDDLVVVGDKCTILEGSLVENHVILKPGTVVMPYQRIPSGQMWAGNPAAFVSELTPDEKEDIQQQALKIFTSTKEHILEFLPYGRTFVHLEELEKQAGLEVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE66</accession>
    <name>B7GE66_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma 54 modulation/S30EA ribosomal protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_16962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185384.1">
        <property type="nucleotide sequence ID" value="XM_002185348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE66"/>
    <dbReference type="SMR" id="B7GE66"/>
    <dbReference type="STRING" id="556484.B7GE66"/>
    <dbReference type="PaxDb" id="2850-Phatr16962"/>
    <dbReference type="GeneID" id="7199311"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16962"/>
    <dbReference type="eggNOG" id="ENOG502QQ0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_2_1"/>
    <dbReference type="InParanoid" id="B7GE66"/>
    <dbReference type="OrthoDB" id="10253151at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="entry name" value="Ribosome hibernation promotion factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="entry name" value="Sigma 54 modulation/S30EA ribosomal protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050574">
        <property type="entry name" value="HPF/YfiA_ribosome-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33231">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33231:SF1">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="Ribosome binding protein Y (YfiA homologue)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Sigma 54 modulation/S30EA ribosomal protein C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="209" mass="23140" checksum="E73B9302979B563D" modified="2009-02-10" version="1">MTRLAATETEVPVIINGQNIELTPALVEHVNKRIGGQINKLASNGAIQECDVILSVSKNPKVKNGHRVEVVTNLKGTSIICHNESPDMYASIDAASHALYRKLCKYKDNRVAGWHGGEKMGNDIMEVLENLEDVSEYTATPVAEEYVDPEAPTITKVKNFDLTKPMSVQEAVFALDYIDHDFYVFRNAETNEISVVYKRHVGGIGLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEQ1</accession>
    <name>B7GEQ1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185567.1">
        <property type="nucleotide sequence ID" value="XM_002185531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr50618"/>
    <dbReference type="GeneID" id="7199433"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50618"/>
    <dbReference type="HOGENOM" id="CLU_456717_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEQ1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
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            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
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            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="598" mass="64136" checksum="18A97955192B313D" modified="2009-02-10" version="1">MKEKNDHSPKTSNHELESNEETGVNSPAESDASSPSCGEQPKQPRSSPESSKVLRNVPDKGPQEASTDGKPIATTAKNEMFAEPAQDIPFPTELQRTAQSTPGAFPQIGMGSTRSSETPVTPHSAPTRDGSQRSGSAEEDFSSAGEPPLLAATLVEDTPERSDTTGTTGPNEAESDKLMVVAVAEPVEQRTDTEKAAFSRGASSKRWRMLYGALLIAGVVALAVGVTLALTIQTSSGSSTTSSSSTALGSPNGTNASVPDDTNTPLLNDTNTNDFNEDVEQPIPGNIPSSAPGGPVVQSTHLVAWESSCMDEKVTAEIQCGTNEILSVQEARIAECTIQSDQGSNRAICLPLTMNGTIESLESANGNDVREIAMVLFQCTGVEDRPNGPVRARLVPTRNVDTTAPANMDWLCVRFNENLQSAIADTVPATAMADFEVELYIVLGDFCLERRSQGDINAVRHRLRTNTRRQLVESNVSDVEVENATGDDTSEGWRLQSFVPGSCQLPARNLLMDAEATGAAENEWLQVCYAFDNDDTGDDDDDGNDANEDELVVVHASVSCRHEIGLGPSRAAVWNEFERRIRPPLIWRELWSTTMTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Z5</accession>
    <name>B7S3Z5_PHATC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176285.1">
        <property type="nucleotide sequence ID" value="XM_002176249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Z5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1298"/>
    <dbReference type="GeneID" id="7205162"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1298"/>
    <dbReference type="InParanoid" id="B7S3Z5"/>
    <dbReference type="OrthoDB" id="48601at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="874" mass="95987" checksum="8692BEA190B8DD7A" modified="2009-02-10" version="1">MADADAPNAPEAGLAPAVAANAPGIVGDAQAAAYAAFAAAEAQMANALAVLAGEAPPDAQPFPPPPGVADIPVGLPPAVVDAPLIDPYDSLLMRAGMNYGTRKAFSKEGYGLMSDLVTLNQKQLESLIDMMNKKHCGKSFQGAIPLGLNLVAEDLEIDIGHKTKTTLKVILHWADLQKSLGLDVNAEDYTDVVGQLARERMDEEEKILEAAKKLTPSKPTTLKDMTKWRSFFENWNSYMSQCRGAAAIPLSYVYRTNKQPETALVGTYVNMDAYLVAQTVLSGSNFEIDNQRVFDEFKEAITTTGPGWSFIKTYNRSKDGRAAILKLKEQAEGTLNESVCRDDAIKILSTTTYNGPSRNWNIDMLLQKFQYVISELVEIDGVALPDGQLVTYLVQALKDPSLSYVNDVQTSGSGASGGSMKGGTGKGASKPTPFKGAVTARSYTPGEWKSLSKDQQEKVRSLRNKKKQGGKPEESERNVDSVARDEPVDTKEVHTSREMEPTSDAAGLQFGRDTCVAGANTVLIGESQKSVTVRPFSSEYSALKNIPIGTVATAYTVPEDGRVVLLIINQALFFGDRLKNTLLTPNQMRDFGIEVDNAPRQYVANSKHSLYVPDSQLRIPLQLRGIFSFLESRKPTQQELDECEHIILTSDVPWEPCSADFARREEEAAKRDRSVSLVDTTGLSTGHAILSAHPYGIRTVAASQRILETFCSLTEVELCETNLADRLIACVNVASDDYCGDGLDGRADLDVYPDSEDFTRVVSVYDGSKEQGGGKHWKEIEQRHHIHRHVTEPHSQWQNRAEGEIREIKKAVRHQLQVSRAPQRLWCFCCEWVSAIRRLTAHDIPALNGRVATELLEGDTPDISEYAQFDCHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4J6</accession>
    <name>B7S4J6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PHATRDRAFT_bd1526</name>
    </gene>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999297">
        <property type="protein sequence ID" value="EEC42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176487.1">
        <property type="nucleotide sequence ID" value="XM_002176451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4J6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1526"/>
    <dbReference type="GeneID" id="7204831"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1526"/>
    <dbReference type="InParanoid" id="B7S4J6"/>
    <dbReference type="OrthoDB" id="49300at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="24494" checksum="E312EDB6E9025929" modified="2009-02-10" version="1">MKFLHILFMKRHRAGEPSNVDSSRKSIYSRILIRKKRAETGHTWDESTTSQESDGAPWRIGTLTGRKAAALSAFSNALTPLFSSAENILVDGAPRGADWWQDTVAGHKMEAQAQQNDEGGTTQAEDINIETTFEESRGEELKEFRNCGLEAWVQVQQAWRRPSGMETDRARIPVRKLRQDLIKRMSECRKFDLPHMIPLKDVIEAYTETWDGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3G9</accession>
    <name>B5Y3G9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_46690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185652.1">
        <property type="nucleotide sequence ID" value="XM_002185616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3G9"/>
    <dbReference type="PaxDb" id="2850-Phatr46690"/>
    <dbReference type="GeneID" id="7204491"/>
    <dbReference type="KEGG" id="pti:PHATR_46690"/>
    <dbReference type="eggNOG" id="ENOG502SQRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006330_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3G9"/>
    <dbReference type="OMA" id="CIRAFRF"/>
    <dbReference type="OrthoDB" id="43073at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="277" mass="30787" checksum="18B67E4C36CED190" modified="2008-11-25" version="1">MMVYQAASSLAGRTLRPYAARFALPVTLCFERSAVRELATMSGSDPLEVLRKESHGRSLCDKQGCRLPGVHWVMSIALPANAASTTKAPSLRTIGIERISDAGIDFVMKRTSPTARSIEAGLPVSILYSQGKYLPGESTEQWRGEGHCELLPLPEILDLVPSFTMVSMVGSQRAVNTAQNDVLRQTETSGERMAVPNKSHLTEIMQTTRMELENGDINMEELESCIRAFRFQPTRMECMLGGPDSIMWDRWEWLRAVPDEASDGSIPWRSPNHLVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3W4</accession>
    <name>B5Y3W4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_46823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185728.1">
        <property type="nucleotide sequence ID" value="XM_002185692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3W4"/>
    <dbReference type="STRING" id="556484.B5Y3W4"/>
    <dbReference type="PaxDb" id="2850-Phatr46823"/>
    <dbReference type="GeneID" id="7204680"/>
    <dbReference type="KEGG" id="pti:PHATR_46823"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003043_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3W4"/>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="351"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141426" checksum="00F2728262CF8CE8" modified="2008-11-25" version="1">MLRDCESFFFHSGNETGMVWHQTKRNDHGIPAKFASSKVVTSFLNQHDLWFGSCLVSKTTGMSSIEKKVRDDTAESETVLFAEETEAFALVKYIGQEGVDYDVPLKRLRSIFDKYLECPSLLDSVLEALTKRLAETAQNDLRTDQQDNYRTMRYALSALYALAKVRGRKIIQRFLPHAVDDVEPIWKALQQVLRWQAVKSDEVAPSKGPPIWESIYMLWNWMGVLSLVPFDCDILADKSLVQALMNSGKTSLQEAGPIRDAAATCLASWMSRPDLEAVEIPDFVRWSTDVIEAYSRQRSNVNLFRTLGVLQTCCAALKLSSVSRKRLLFHFQALWDPLLDLSQTIRDDFSLQKLLIKWWSRMSCAHLPPRVATWRYQRGKRSLLNNVRPIASAHDSTLLTSSLAHDEIEKDSIFLVPDEVEDALGRILEGLGHLSTIVRWSAAKGVGRVTERLPELCGEDVLDAVLEFFDDEENDRLWHGGCLALAELARRGLLLPARLGEVIPQVIRAIQFDLQSNHSSVGAHVRDAGCYTYWAFARAYSPEVMKPYLSSLSKAIVLTSLFDREVNCRRAASAAFQEAVGRQGAANFPNGIAILTVADYFSLGNRRHAYTSLAFQIAKMDGYTRPLIRHLQMVKLFHWDITIRKLSAETLGIMSAIDRDYVMLDVLPFLLEKSLDVKNLRIRHGATLGVAESLLGLSKTKAHEGLPEAILVDITLLVDEIEKKRLYRGRGGEIMRSAVCRLIECIAIAKLPLSVQEQVRLLDSIDASIPHPSESIQDNACCALQVLLVSYFPVGVNGPSQRLQRRIVDKFVNIISNETNPAATRGYVKAIGYLPAKLLAPNRSVLAGIIDCLRKAARYDSLVGGESDAESRRNSLQSLSSIASEVGIVDVSRQSENPQVSLGRNLLDTVFDCFFLGLEDYSIDRRGDVGSWSRVASMDAMVELLTKVAAIPNPTLFDQSVPYRVVSSIVKQLSEKIDSVRQKAGDCLTRVMLLSSIAVFVPCRAEIVEALGIEDENDHNWSDASFTFPRVVKLLSLNIEKGEDQRCGALYYTSVLSGLIVSAGGLTESVNKEASFVLIEFAKQCQGTRELEKLATCLMDLFEEHVGKGRFVLPLLKTLEKMLAYRVFDTLLLDPQTSHFATRCMDCLVREERSCRDVPRLLQLTKVIVALLPGVPDAVEHRGVALLCKLTSHPFPRVRSHTAEQFYLVLLENQGFGSSSNPKVLEIILTTPWGSELDNLFLSDKTKEVAEHLAVLRELEDLCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y403</accession>
    <name>B5Y403_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related GTP-binding protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_21147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185754.1">
        <property type="nucleotide sequence ID" value="XM_002185718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y403"/>
    <dbReference type="STRING" id="556484.B5Y403"/>
    <dbReference type="PaxDb" id="2850-Phatr21147"/>
    <dbReference type="GeneID" id="7204712"/>
    <dbReference type="KEGG" id="pti:PHATR_21147"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y403"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35258" checksum="179209C2A31C169A" modified="2008-11-25" version="1">MAKKKVLLMGKAHSGKTSMRSIIFANYLARDTTRLSPTLDVEHHHVRFLGDVMLNLWDCGGQDAFFESYFERDRETIFRSVELLIYVFDIESESPEKDFDHFCGVLEAIEENSPDARIFVLVHKMDLVAPQDRAHVLRERESLVAESCQSCGVQNFAVFGTSIWDETLYKAWSEIVTNLIPNIRLLETHLRNFCRLCDADEVVLFERATFLVIAHAQAADKRTGHFDAHRFEKISNIVKQFKLSCGKAQSSFQGMQVRNSRFSAFIDAFTANTYIMVIVSNPHVQTAATIWNIQNARTHFEKFIPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4A0</accession>
    <name>B5Y4A0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_13333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="2"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185801.1">
        <property type="nucleotide sequence ID" value="XM_002185765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4A0"/>
    <dbReference type="STRING" id="556484.B5Y4A0"/>
    <dbReference type="MEROPS" id="C26.001"/>
    <dbReference type="PaxDb" id="2850-Phatr13333"/>
    <dbReference type="GeneID" id="7204762"/>
    <dbReference type="KEGG" id="pti:PHATR_13333"/>
    <dbReference type="eggNOG" id="KOG1559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058704_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4A0"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="31877" checksum="7362B152921CBBB6" modified="2008-11-25" version="1" fragment="single">PVIGILSQPLSSNVESDDYIAASYAKWLEAGGARSIPIPYDADEHLVEDLFQQINGLLLPGGGSEMPPAVTFLMDKIVKSNTDGLYFPVWGTCLGFEFLLQYAGGPTFLESGFDSENVSLPLYEVEPRELYADPIVYLTVTQRNVTMNNHQLGVSPDRFRDNNLASQLWDITSINTDSNGQPFVSTIEPHHPDIFPIYGVQYHPEKNAFEYSTYPGTNIPYEAIDHSSEGLDFSIRMARFFVAKARRSLDSKGNSHFYTKSDVYPSIYTYPVRTGLKFEQIYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Y8</accession>
    <name>B5Y4Y8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186089.1">
        <property type="nucleotide sequence ID" value="XM_002186053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Y8"/>
    <dbReference type="SMR" id="B5Y4Y8"/>
    <dbReference type="PaxDb" id="2850-Phatr33318"/>
    <dbReference type="GeneID" id="7204193"/>
    <dbReference type="KEGG" id="pti:PHATR_33318"/>
    <dbReference type="HOGENOM" id="CLU_1334171_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Y8"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22961" checksum="6606D381BDA12A11" modified="2008-11-25" version="1">MAPREAKFVHRYAPAETALHRVVRSLRVVSCQEVTNAFANGQNNQTPPQTDSNEDSREPETAEETVTENEEFGNLMLAAIGSILKAYPAAASIPNMFGRTAMHLVCMDLSPARKEAALLLLEHSPQTVKEIDHFGRTPLHYVLDQQQNSITSNLSLELVRSILLHDPKALQQCDTSKETPYDLLLKQDLSGCSTALQQLLDEHREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y557</accession>
    <name>B5Y557_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_51604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186412.1">
        <property type="nucleotide sequence ID" value="XM_002186376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y557"/>
    <dbReference type="FunCoup" id="B5Y557">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y557"/>
    <dbReference type="PaxDb" id="2850-Phatr51604"/>
    <dbReference type="GeneID" id="7203997"/>
    <dbReference type="KEGG" id="pti:PHATR_51604"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_1_1"/>
    <dbReference type="InParanoid" id="B5Y557"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="347"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="509" mass="57664" checksum="23B5790352725855" modified="2008-11-25" version="1" fragment="single">QPKNLADGCILKDYQLEGVRWLASLYENGVSGILADEMGLGKTIQCVALIAHLLLQGVSGPFLVVAPLATLPNWVREFEKWLPQHPVVRYHGTAPEREAMLKGPLNPKLRRSPNFPFIVTSYEVSIRDQAKLEKLTEFTYLIVDEGHRLKNHRCTLLTSLKRLKAANRLLLTGTPIQNTLDELWSLLNFVNPQIFDDLSVFQSWFGFKDIGQKTRGGTDETSIIIEERKNQTVTKLHEILRPFLLRRIKLDVLSEMPPKKEVIVYSGISKLQAGYADLIDKGTLRDTLIAQGIENGRTLSQTNKLMNHRKNINHPFLFGEPIDPASGVHLGTAHPQLLVRASGKFALLDRMLSRLYRDGHQVLIFSQMTSVLNVMEDYLLFRNWNFCRIDGSTNIDERQRQMDQFNAEKTAGENGRRSKADDRHFVFLLSTRAGGLGINLTSADTVIIFDSDWNPHADSQAMDRAHRLGQDLPVAVYRLLTVNSVDIEMMEKQISKKKLERMTIAGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5B9</accession>
    <name>B5Y5B9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_44097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186159.1">
        <property type="nucleotide sequence ID" value="XM_002186123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5B9"/>
    <dbReference type="PaxDb" id="2850-Phatr44097"/>
    <dbReference type="GeneID" id="7203864"/>
    <dbReference type="KEGG" id="pti:PHATR_44097"/>
    <dbReference type="eggNOG" id="ENOG502SP5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351437_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5B9"/>
    <dbReference type="OrthoDB" id="45127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="801" mass="88139" checksum="038908C356987C29" modified="2008-11-25" version="1">MASETGVRQQFFYEQLGAPSLLYREKGSYTTLDEEPNPSTGRAAIDDRHLRLIRSRAQWDQPVPQDILRSSLTHNAKNTPALHAFPTAGAKIRRQAQKTDRVSLATQAESCRYIPDGLNCVDPAYLAPFDAETLKEGMTPFQDHVAAAGVKRRADEDAPAIPWGDCNAPEQYGNCIALMPCACCNCKDNEDHTWALLHPVGPLLDRVRLSHVSLPRGRFILEDLPLPPCRRDLNVDDRVRQIAQCGPNLFVARTSINCTGFSIQESPRLETCDDTTKCLGKKFYLQQSFQIDERFTTETPRSYRPLDLCSHPKYGVVTNSLLAIVYESEQNKRSTVHRLSVDSEAVTHKTEHNIVNLDRIANIDFGAQSPMVLWSAARSYVRPSPTISAGNPKPRVGHGNSLYSIDLRTNEGTFQWSPSAELYVVEGTHSISGIKTDWVNGTSVWAASVSAGKTWEIDVRMPCQTVTTWSLPHACEGSNSTVSTSGVYGEGFLFEQPVKGYGYDDDYVAPQTLLGVGKNPNSYGIHIYQRPALGPLFQSQSIEAPACPGITFLQNSSVATSSSFALPDVSSNIFTCGIASFRTPGEQLQENSDFNKTTYASNALCIVSSTNKGDVYTHTLIESKNTNKHGRPFKGLPIGSVAVPVTSIDSQIYSSPDVLFWHLRNKSPLAGHAIVGPAFTEKDRTKKIRKKLDCKSKDNASMSFETDVVAIKPTSEPLFLTADKREAATVKLPSHLASKAAGMLTTTLKCFDTERTSKVERSVEGQLLHSDINANVFRTISTAWELGCTSDEFEHSDTSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5K5</accession>
    <name>B5Y5K5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_33540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186487.1">
        <property type="nucleotide sequence ID" value="XM_002186451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5K5"/>
    <dbReference type="FunCoup" id="B5Y5K5">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y5K5"/>
    <dbReference type="PaxDb" id="2850-Phatr33540"/>
    <dbReference type="GeneID" id="7203910"/>
    <dbReference type="KEGG" id="pti:PHATR_33540"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="InParanoid" id="B5Y5K5"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18071" checksum="D860B309766953D1" modified="2008-11-25" version="1">MTDPSPNDDFYLRYYVGHEGKFGREFLEFELYPSGKLRYANNSNYKDDDLIRKEVYVSPAVVEEFRRLVEVSEITKVDDSKWKEPDERSTGHQELECKIGSHHIAFTACEIRSLGDIQKWNDPEGLQTFYYLTLDLKALVMALISSHFKARPIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5L4</accession>
    <name>B5Y5L4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fucoxanthin chlorophyll a/c protein, lhcf type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lhcf14</name>
        <name evidence="11" type="ORF">PHATR_25893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186206.1">
        <property type="nucleotide sequence ID" value="XM_002186170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5L4"/>
    <dbReference type="STRING" id="556484.B5Y5L4"/>
    <dbReference type="PaxDb" id="2850-Phatr25893"/>
    <dbReference type="GeneID" id="7204099"/>
    <dbReference type="KEGG" id="pti:PHATR_25893"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_4_1_1"/>
    <dbReference type="InParanoid" id="B5Y5L4"/>
    <dbReference type="OMA" id="CVETYGW"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838824" evidence="10">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="195" mass="20973" checksum="851F5E5DF8DB2758" modified="2008-11-25" version="1">MMKLALIASLVAGAAAFAPASKQASSSALKAFENEAGVIQPTGFFDPFGLSKGKDMATFDQYRTAELKHGRVAMLCVIGYVVPEFYRFPGDIAPGLKFADVPNGVAALSAIPALGWAQIFFLVGAVDYWGVLGDFEYGKPDLDADTLAKRQTQELQNGRLAMLATLELLRHDSQNYVSPGFDGLDNLITGLPFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5R5</accession>
    <name>B5Y5R5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ACD1</name>
        <name evidence="18" type="ORF">PHATR_25932</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186235.1">
        <property type="nucleotide sequence ID" value="XM_002186199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5R5"/>
    <dbReference type="STRING" id="556484.B5Y5R5"/>
    <dbReference type="PaxDb" id="2850-Phatr25932"/>
    <dbReference type="GeneID" id="7203934"/>
    <dbReference type="KEGG" id="pti:PHATR_25932"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="InParanoid" id="B5Y5R5"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="51"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="280"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACI65705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="436" mass="46662" checksum="8B4208F80C7271A4" modified="2008-11-25" version="1">MSLLTRAVTFARPSLANAAFRGSVASNKAVGSSPLAGLSRKSYMTYSMLPEEHRMIYEMCRNFANEKLAPHAGEWDEKHMFPKDAVTQLAELGLMGINTPEEFQGSGLDAMSYAIAMEEISRGCASVGVIMSAHNSLYLYPVQTFGTDAQKEEWAAPYAVCDDGSGGKLNIGCFGLSEPGNGSDAGAAATTATLDGDEWVVNGTKAWITNAHESGAAIVFATTDKSLKHKGISAFIVPMDAPGFSLGAKEDKLGIRASSTSNLIMDNVRIPKDNLLGEPGMGFKIAMQTLDGGRIGVAGQALGIASASIDCAVKYALERHAFGKPISELQSIQNKISAMTVARDSARLLTWRAAQLKDNGERFTREAAMAKLAASEAATMCSHQAIQILGGAGYVRDFPAERHYRDARITEIYEGTSEIQHLVIANDVLKEYKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5X0</accession>
    <name>B5Y5X0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_7562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185985.1">
        <property type="nucleotide sequence ID" value="XM_002185949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5X0"/>
    <dbReference type="STRING" id="556484.B5Y5X0"/>
    <dbReference type="PaxDb" id="2850-Phatr7562"/>
    <dbReference type="GeneID" id="7203938"/>
    <dbReference type="KEGG" id="pti:PHATR_7562"/>
    <dbReference type="eggNOG" id="KOG3383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_0_1_1"/>
    <dbReference type="InParanoid" id="B5Y5X0"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="053EA60023BC9CDF" modified="2008-11-25" version="1" fragment="single">IKSEPSEFSIHNLEARPRQREEWDGVRNYAARNHIRSMRENDRCWFYHSACKTPAIVGTCRVVRTAAPDATALDSNHPGYDPKSTAESCRWDSVLVELESIFESPITLKELRAQAKINKTVASMTILKMSRLSVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNV6</accession>
    <name>B7FNV6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_31619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177104.1">
        <property type="nucleotide sequence ID" value="XM_002177068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNV6"/>
    <dbReference type="STRING" id="556484.B7FNV6"/>
    <dbReference type="PaxDb" id="2850-Phatr31619"/>
    <dbReference type="GeneID" id="7196284"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31619"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_3_1"/>
    <dbReference type="InParanoid" id="B7FNV6"/>
    <dbReference type="OMA" id="QKYAISG"/>
    <dbReference type="OrthoDB" id="60308at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="29753" checksum="236D202C523DED38" modified="2009-02-10" version="1">MTNSDNHADIIEACEGGVCRPRGVADNARASTAIPTERAESTDNKLSIKIDIISDTMCPWCFVGKRNLETALRMVPEISAEVNWLPFFLDKNLPEEGKLVKDYYIQNYGDPNAGERMMPHLIQAGKKSGIEFGSAFVEAERLFPTIRSHRLIEYAKRQGKQNQMVEELFHIYYEEGKRLNSVSDLENAANAVGLNGDVRAYLLSDQDEKEVFETAAKIKKDASGVPTFLFSRSDLPEMKPVSFSGGQPPTSFLAIFKHLSTASDDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPC3</accession>
    <name>B7FPC3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA terminal phosphate cyclase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_42732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176684.1">
        <property type="nucleotide sequence ID" value="XM_002176648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPC3"/>
    <dbReference type="STRING" id="556484.B7FPC3"/>
    <dbReference type="PaxDb" id="2850-Phatr42732"/>
    <dbReference type="GeneID" id="7196124"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42732"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPC3"/>
    <dbReference type="OMA" id="WSPPIDY"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000002">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="12">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="408" mass="44484" checksum="A9C22BFAB1A3A8F2" modified="2009-02-10" version="1">MSSCRKPNEIEIDGSKGEGGGQILRNSISYATILRKPIRITKIRSNRSKPGLKAQHVASLQLPTRICGVVLKGDAIDSQIIQYEPGKPRITTSQLEQINLTSNIETAGSICLLIQAALPCALMGSAVPISLTLRGGTNATMAPQYDYWERVFWPTLRDLFQLQPNQVEATVVRRGYFPKGGGLVRIRVLPICEALPPISMTERGQVVEISIRAFHAGKLPIHLAKQMASAAQHFLQPRFPNTPVYTEVVTEKEAVGSGLGIIIVATTNTGCRLAGSALMERQQKAFDVGVRAATELWSTIQDGGCVDEWLQDQLILFMALARGESKILTGSLTLHTQSAIEIAKVVACAEFEVTRILDEGDDIVAKTVTNCRYGEAGRIPGKHIIRCRGIGFSSYCTPEEITQSDMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPE7</accession>
    <name>B7FPE7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_31811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177198.1">
        <property type="nucleotide sequence ID" value="XM_002177162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPE7"/>
    <dbReference type="PaxDb" id="2850-Phatr31811"/>
    <dbReference type="GeneID" id="7196381"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31811"/>
    <dbReference type="eggNOG" id="ENOG502SRK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684197_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPE7"/>
    <dbReference type="OrthoDB" id="49204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="404" mass="43280" checksum="010BE22CFCED6672" modified="2009-02-10" version="1">MMDVDISHAFRRPGNKRQISTDAFQTISWTLSFVGLKTRLTVTPRANVSVIVSSGNREKLGTASLVHHVMLEYRERKEHCVGKGSSCFCFSSNFIPRSIMSDTAAFFANKKKKKKAFKFNANLVDASSVAATAHIDAPALSTDHDPNDAPAHRASEASSASAPAAAAEQWDDEALAVSIGTRKASTAAASTSGAEVLDMKSLEISRKDDHNIAEKLRVQETKAQLAAAREGMERQAAKLKEEKEMKEAKKTAVAPRFTAAAGRSGGTWVAPHLRAGAGGSLARRLGGSTGVLGQKLDVQDEQLFPDLAAAGKILEQKEKEQQHLKAPKKTPVGGGATWASKKALPKKEESKDDPGSHSQSNSEVPEPQVKPVPTATPVVKPVVSKPTKEKKKKKDLSTFKPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPK8</accession>
    <name>B7FPK8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_31876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176731.1">
        <property type="nucleotide sequence ID" value="XM_002176695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPK8"/>
    <dbReference type="PaxDb" id="2850-Phatr31876"/>
    <dbReference type="GeneID" id="7196162"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31876"/>
    <dbReference type="InParanoid" id="B7FPK8"/>
    <dbReference type="OrthoDB" id="44357at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22293" checksum="A766487F2DEF46AD" modified="2009-02-10" version="1">MLLSMVTIESRNSHIMFLNTQLRLRLSKTIRVGICGQTHKISFDRLALGATTQVVRAIARTVDNPGNFVVEFDDGTEEVHGDQALLDAVYKQVDDDGNEWFTFDDIVDHQKRPRGGWGRTRGWFLRVKWANGEFTWEPLTSLKESNPYPVAKYAADHDLLSEHAFSYWAPTVLKKADRWIRAAKTGKKKIDTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPY8</accession>
    <name>B7FPY8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hsp70_1</name>
        <name evidence="5" type="ORF">PHATRDRAFT_17633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177297.1">
        <property type="nucleotide sequence ID" value="XM_002177261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPY8"/>
    <dbReference type="FunCoup" id="B7FPY8">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPY8"/>
    <dbReference type="PaxDb" id="2850-Phatr17633"/>
    <dbReference type="GeneID" id="7196473"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17633"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_1"/>
    <dbReference type="InParanoid" id="B7FPY8"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="72738" checksum="36E525CB9089F4C1" modified="2009-02-10" version="1">MALQFSVRKGIVASSRIPVIGTSSPFLTNKRWQSSKDAGDVIGIDLGTTNSCVSIMEGRSARVIENSEGTRTTPSVVAFTNSGERLVGMAARRQAVTNPENTLYAIKRLIGRRYGDKEVEAISKLVPYKIIKSDNNDDAWVEAQGTKYSPSQIGSMVLGKMKETAEGFLGRTVSKAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAASLAYGMDKADGKTIAVFDLGGGTFDVSVLEIQGGVFEVKATNGDTMLGGEDFDEELLEYLLAQFKKDSGIDLGGDKLAMQRLREAAEKAKRELDGLAQTDVSLPFITADASGPKHMNVKISRSQFENMVQKLVDRTIGPCKSCMKDADIKKSEIHEVILVGGMTRMPKVQSTVEEFFGKKPSRGVNPDEVVAMGAAIQGGVLKGDVKDILLLDVTPLSLGIETLGGVMTKLIPRNTTIPTKKQQTFSTAADNQPQVQIKVLQGEREMAADNKMLGNFDMVGIPPAPRGVPQIEVSFDIDADGILNVSAKDKGTGKEQNIVIQSSGGLSEDDIEKMVRDAEANAESDSRRRQTIEAKNEIDSLIYSTEKSLTDNADKLDEATKSEIEKAIAEAKEVKDGDDLEALTAKKDALSQASLKIGQAIYGQGSSNTDEEEKKDDTVDADFQEKGSDEKKDDDKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPZ0</accession>
    <name>B7FPZ0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177298.1">
        <property type="nucleotide sequence ID" value="XM_002177262.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPZ0"/>
    <dbReference type="PaxDb" id="2850-Phatr42902"/>
    <dbReference type="GeneID" id="7196474"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42902"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396125_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPZ0"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1343" mass="146766" checksum="4182B9F7A772C8CB" modified="2009-02-10" version="1">MNSKGSNDPPLEKKRRLSVRDLPQFCDTAGTVSVASFGARRLPELRHLWEKTFRRASTPDPSNVESLKSTGCKTSRRHLRRRATSHLGRKHHRFPAGQQDANAQDKKSEHSIIEEPKLTRRKRRRNTEHLHSSHEEWKVPKGALGIPSTEDKESNGNNHRPDNWMPTHLWHVKRFHMESMWGWKVPMLHSNRGAKAALRLAREGKTILHDATWTSQPVWLRIATEVVPDMIDQIRIIIPDFALDETKLLEAFAYQPSAFPKGGIGPVAWLCSTSPLFGSAKDDTQSCYIYFFLHPSIQQTLLHILRQILEPSTLTGPLCFVHGGLSWLRLRGKAALESLLMAMLSIAKDEKRSTDIGAIIADLETGIDCQLSHVQCRAATNHETPNSQEVKLILRRPVQVDFHGNFGSCGVDVVCEPSLGQKLLVALVLHGMACPIGVTELAHLELECEPPRPLFPRDYPDTSVGMSYWKAALPEWKILRAYYEGGLGRIRPDLSEDETTVVTVRGSFGQPFQQAINGIGYIHRNGDKASNSGAAAESLVIRRSRRKSGNPSLPVQAPPISRDQVSQHRNLCKTLLLSLSLPAVLLAHICLHEKGQLDTGTLLYATDGSVNEPLGVVTAAIFSSGRGRYHGIAVVGAARLLEALQHAHDSCAGRIVAPRVGPKRIELEIGVASKVDNVWHTVVAALMAHPVRLSKLGRWAASATSSRVFFVGALRLTSAFTVANPTSAALTPDAGLQDVKPIPITVLAGFLGSGKTTLLQNLLENNEGLRIAVVVNDVASVNIDSKLVANQNLASGMVELQNGCACCSRSEELLASVQELVTLSDTRGEGESFHHIVVEMSGVGDPRSVRAKFQEAVLYDMPLMQRAQLDTMVTVVDCSSFLTNLNSDKVATPEDTPELYYRDEDEAKADRKWMEDDDLPPGLLEAIEAGDRASANAVADLLVSQTEIADIVLLNKVDLVDESSRDMKQIENIVTALNPRATLLKSAFGKVSLQQILGVAQGMGVAEAGIIDDHKDAVNAALEMAHDPDCEDPNCVDPSHSEVVAVVDCAKPDCTDSSHEHSHTHACDDPACDDPAHAKMTVCGEPGCTDSHEHSHTHACDDPSCDDPAHANTVAESVCNDPGCTESHEHSHAHACDDPSCDDPSHGVDVGTHAGIGTYVYTSRRPFHPTRLLSFLRNLPATRGLPPLEAGEPDLAVSATAKSAMKKILRSKGFVWCADSFEVARYWSHAGISFELTNLGKWWATLPREQWPQEAIRAILADYDDANHDDQSASTGTVGDRRQEVVLIGPGMGGPTAQKEVSSILDKCLLRDDELDFFNEKKLDEGALQKAFPNPIQAGIMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPZ1</accession>
    <name>B7FPZ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176794.1">
        <property type="nucleotide sequence ID" value="XM_002176758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPZ1"/>
    <dbReference type="PaxDb" id="2850-Phatr42903"/>
    <dbReference type="GeneID" id="7196536"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42903"/>
    <dbReference type="HOGENOM" id="CLU_1809933_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPZ1"/>
    <dbReference type="OrthoDB" id="37652at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852524" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15890" checksum="BE3B75E0670B12D7" modified="2009-02-10" version="1">MKTTIIASYLALLAAISVVNAFVPQSSANVFGRGSALGAKYNSMDEILALFPDDKPVLINFYDAGTENSIKDDILRAKNLLEDRAKLVSIKQQDYPEIAKLWDADSKSPSMILFKDGKPVTRLYEQTHYLEIVAHMGKFCDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ43</accession>
    <name>B7FQ43_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177329.1">
        <property type="nucleotide sequence ID" value="XM_002177293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ43"/>
    <dbReference type="PaxDb" id="2850-Phatr42948"/>
    <dbReference type="GeneID" id="7196778"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42948"/>
    <dbReference type="HOGENOM" id="CLU_502977_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ43"/>
    <dbReference type="OrthoDB" id="49358at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="542" mass="62045" checksum="275AAB830CB30F8D" modified="2009-02-10" version="1">MEETLPITERVSLDVPESEVVIGARALQLRLNEREANHREELSWLRMELDTTRREKQAVEDRMSELYRNMQDIQERDKPNDANSVQVSSDPVMPLQHQLDKYERIVRVMNNQIALVRSSSDSVVRSLKDEISDLMDEKCRVELELMNQVTNLECDKKELLLRLDSGNGSSDELDVSAETVIGEVMESDDHRARSIRLAIDNAKLKRQVLEEQDISKARETEKSSLLERITNLQDEVTLLRSSAAGLQTLDQLKENRQETITALERLAFLWDRVDQAMQLMDSKIREFRDQGPIDSRNQIRPSSALTSERVLSSMETGALVYGQLQVSLMLIELKLRNNLVDLNNEGSSQAATLSPIPDASLHSQVKMVQIEAMTAIDQVEQIVKEQVQQLEEQSKNETNVTRKALEDKASQFESLQKRHLALQTQVDNLKPEHINVATELKDEHTMELLVSQSVMDQLQVEVLQVVKHIRSKNKKIDELTVLIDAQKSREQTLLNELKRFAKKQKESTGKAKRQPESEEEARTVGFNEIDRDHEAEVGEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQJ2</accession>
    <name>B7FQJ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_24935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177412.1">
        <property type="nucleotide sequence ID" value="XM_002177376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQJ2"/>
    <dbReference type="FunCoup" id="B7FQJ2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr24935"/>
    <dbReference type="GeneID" id="7196712"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24935"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="B7FQJ2"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="331"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="455" mass="50843" checksum="4BF742BAE1CE2387" modified="2009-02-10" version="1" fragment="single">MNSASTRQLQNLRRFLARPSSCRKRQHNTAVAYVPKRVKNQSIHDSLSRESAAVTSCRRLHAPGSTDHNPGESATQPDELPNFDDLVDLDPILKSILKENGLQRMTEIQAKTWDASVGGNDVIGRARTGTGKTLAFLLPSMERLLRNKHSGNQIRALIISPTRELARQIGEQAQMLVHGYKRTHSSQVMYGGASRERDVRDLERRIPSILTATPGRLIDHLNSTQVKSKPFGNYLSDVDVLVLDEMDRLLGMGFCDDIVEILQYLPQNRQTLLFSATSPPEVRRMIDQCVKPNHTVVDCMQEGDPSTYTNTIVGQRHVVLPPDRIVSGVLQIVQLLMMDPDYKILVFFPTTAQVTYYSQLFNRGIGLPVLSIHSKMSQSLRTNNSDRFRFASRAVLFTSDISARGVDYPDVTHVIQVGAASDSETYIHRLGRTGRAGKKGQGLLILTSDEIDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQR5</accession>
    <name>B7FQR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_43135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177451.1">
        <property type="nucleotide sequence ID" value="XM_002177415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQR5"/>
    <dbReference type="FunCoup" id="B7FQR5">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQR5"/>
    <dbReference type="PaxDb" id="2850-Phatr43135"/>
    <dbReference type="GeneID" id="7196899"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43135"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="B7FQR5"/>
    <dbReference type="OMA" id="YVEVDCI"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855310" description="ATP-dependent RNA helicase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="152"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="368"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="587" mass="66031" checksum="D9F5AA45C7E6F5AD" modified="2009-02-10" version="1">MWKTISFLVCVSILYSSTLPQIQGWTGETKLMRRPVSARRRRACVPPGHNHHHRDAYSLCLTNAADEYNADASASKRRRVRGPIRRAASPIAAQAQERVVSARARHEQATQDPTLLTTYRFDERADLHPGTKRAVTEVMGFQQMTEIQYKTFNAALEGKSVLGRARTGTGKTLAFLLPAIERLMFMDVSVYRADRNVGILIVAPTRELAMQIGSEASRLLTFESKWSVLTLYGGTKIQRDVALLNRQIPTILVATPGRLLDHLEDTRLRGRKFSDVVGETPIVVLDETDRLLEGFAKDTRRILSFLPRPEKRQTLLFSATVPTRLKRILDEILPADYVEVDCVGNNDSSKQTNKRVTQSYTLLPAMDSYVSYLVSITKQAMEEEKDYKIVVFFPAARLVRFFTRFFNVGLGIPVLEMHSRMSQSARTRINSSFRNAKRGVLFTSDVSARGVDFPDVTLVVQYGAPSNKELYIHRLGRTGRAGREGKGLLVLLPFEKKALKEIDLQRLICVNIEDHKDLMDKVDFAQNLVRSGHPLLTPNAEAAYLAFVAYYMTSKGMGSRDDVVDAAKVFAQIIGLPKLPDLWGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR00</accession>
    <name>B7FR00_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
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        <property type="component" value="Chromosome 1"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC51958.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="487" mass="51547" checksum="05475C07C857D0CB" modified="2009-02-10" version="1">MVMLSDRVNANGEEDKEDETNLATQDMSEQSKPITTPGSVEGRRLSHDQSDEPPTLEVGQGSVDEAIAAHNPTQPLQPEVLIKGASPASLDSHPSNVGEGKTSQSLFACPAEGNPSNVVVSMPGTFAKVNSGEDLDQGTRPGGRLLSYESLEAFSKSSRPTSVQGSLPGSSQAYSASSNGSSSDHTEEPSSLPNIITTSAPGTGAQPLTSTSPTSSNTSVRKTSGLRRGKWTVEEEAYVARVIQDFNSGFLDAPAGTTLRTFLSEKLQCDPMRITKKFTGDACIGKRVFHPAVRSPSNGTAIDKAQAELHGLERRWQRRLELQQRESAKKAAASAAAAAAATGRNFSVQTASVDGTASVGENRAKTKTDGPNMVTQTASWLDRAKSVLQDPSPASSMSQQSHSEDFAKSEIMSQMQEVQRLLHEGPTIQKSSADLPDMMDKARSKSGSSSPPVEPADKRLRTGAEDAEALVGFLRSVRASAASGQEF</sequence>
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    <accession>B7FR64</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Bacillariophyta</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002177492.1"/>
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    <dbReference type="GeneID" id="7196975"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43266"/>
    <dbReference type="HOGENOM" id="CLU_377432_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR64"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS29</accession>
    <name>B7FS29_PHATC</name>
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        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177907.1">
        <property type="nucleotide sequence ID" value="XM_002177871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS29"/>
    <dbReference type="STRING" id="556484.B7FS29"/>
    <dbReference type="PaxDb" id="2850-Phatr18087"/>
    <dbReference type="GeneID" id="7197416"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18087"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="InParanoid" id="B7FS29"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="390"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC50721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="499" mass="56083" checksum="0064E77013BF40FC" modified="2009-02-10" version="1">MSSNAEKFLEAAATFPADALPSHRTYEHPLVSRYATKEMSFVWSPAMKFTTWRKLWTALATAEQELGIDITDEQLEEMRTNLFRVDFELAAQKESEFRHDVMGHVHAFGAAAPKAMPVIHLGATSCYVGDNTDIVQIRDALKLVQRKLVKVLATLKTFAEKYRDLPTLGFTHYQPAQLTTVGKRCTLWMQDLLLDMERIDTELEKLPMRGVKGTTGTQASFLELFDGDHDKVKALNKRVCELMGFNKVIPVSGQTYTRKIEFYIISVLSGIAQSAYKMCGDIRLLANLKEVEEPFAKTQIGSSAMAYKRNPMRCERVCSIARYVMGLPDGAAHTHAAQWFERTLDDSAIRRIILPEAFLGTDVILSLLENISDGLHVWPEVVKAHVMAELPFMATENIMMECVKAGGDRQELHEVIRVHSMDAGAVVKGEGKPNDLMQRIKNDPLFAPVHSKLDEMIDPRKFCGRAPEQVDEFMAEEVNPVLEQHKDLLKIASVDGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSN9</accession>
    <name>B7FSN9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178015.1">
        <property type="nucleotide sequence ID" value="XM_002177979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSN9"/>
    <dbReference type="STRING" id="556484.B7FSN9"/>
    <dbReference type="PaxDb" id="2850-Phatr32803"/>
    <dbReference type="GeneID" id="7197303"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32803"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019167_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSN9"/>
    <dbReference type="OMA" id="FRTAWYA"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF0">
        <property type="entry name" value="ATPASE GET3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855279" description="AAA+ ATPase domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="464"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="800" mass="85979" checksum="77854FD173B90A50" modified="2009-02-10" version="1">MVIALRRMIKLRASILAVLLISCYVSAFQPNPIHSNRRATSRGPSTSCERNIPTGFGRPSPSRFDLDFQKHQSQYGKLFSLNKLVEDISSRSPGQLPSTVFVGGKGGVGKTTVSSALAVSLASAIEKDLKVLIVSTDPAHSLGDALDEDLRKNNGRPVAMTDSLTGGRLDACEVDASAALEDFRENIAAFDIDRLADALGVSVDLLESFGLREFSGLLNNPPPGLDELVALSNVLDSESVAKGYDVVIVDTAPTGHTLRLLALPKFLDGLLGKLIKIRLQLSGLASTLQTFFGNDEAQKRAKSIDDAVNRLEQFRRKMSNLRERLQDSQSTRFVVVTVPTKLGVAESKRLAAELNYQGVSITDIVVNQCVGGIDDDVDSEALQQYYDRRKDGQKKWIAKLEEAVQDVSCSEEYKANGSSAPIGITRVPFFDVELVGVPALGYLAAQCFTENLSFAHLMNVDSSNEPRVVICGGKGGVGKTTTSSALAVSMASKGHKVALISTDPAHSIGDAIEIDLSGGKLVDVPLIGIPTTDGSLSVLEIDPSTAINQFKGVVDQLIGGDDNPSDAGLRNTLRDLQEVFDTLPAGTDEVVALAKIVNLVKKGGFDRIVLDTAPTGHTLRMLSTPGFLAELIDRLLIIAEKVNSNTAIKMLIGSSARSEDISNAAATAKSTLLSFQLQMYDLENLFADAAQTEFLIVTVPTELAVRESMRLLNDLTFESPDMPIKCRNIVANQVLGDDGNDAKTFLDHVGQTQAISVKDLEDAVSSYPAPPLITKIKYLDTEPRGVFGLKVLADELLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT47</accession>
    <name>B7FT47_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177776.1">
        <property type="nucleotide sequence ID" value="XM_002177740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT47"/>
    <dbReference type="PaxDb" id="2850-Phatr43689"/>
    <dbReference type="GeneID" id="7196992"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43689"/>
    <dbReference type="eggNOG" id="ENOG502SF0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1655598_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT47"/>
    <dbReference type="OrthoDB" id="45939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="211" mass="22677" checksum="B393FE3E58A353EC" modified="2009-02-10" version="1">MIVMGRISFTVCCWLILPITAFQVSRNLLTKSVRDRQDAVLWSTRKDFVATMTGASLVLATIGAFPLEPAVASGGATAGGVYLLSAKQRYNDRVSKGVAGFLALGAALENGDIDSVRAFFASEEVGSWKDFSAAGYLLANAFRRNSSAAPDTLPSVKKWKAYTAEVENMNKALKKKDTKKALDSYAVASLALDEYLEKVELPPGKDLLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT92</accession>
    <name>B7FT92_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_33007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177801.1">
        <property type="nucleotide sequence ID" value="XM_002177765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT92"/>
    <dbReference type="PaxDb" id="2850-Phatr33007"/>
    <dbReference type="GeneID" id="7197017"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33007"/>
    <dbReference type="HOGENOM" id="CLU_1513426_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT92"/>
    <dbReference type="OrthoDB" id="48561at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="19732" checksum="3E04CFDBB7987481" modified="2009-02-10" version="1">MQRRQASSYAPTKEPSPSRITGKHTAVRTKPRVEGGISSGALIVIAVVLTLATFLFPSEMNQVEQEAGYLAQKAEHDLMDWVHRDGGSSQVSSSKWVDGEKRLKVKLKELADRQAKGLDIGVPVLTRYLGEDIPAWPDATITKEAWNAKVAEKYAEMSREEEEWRAKVAAVVSKDQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU10</accession>
    <name>B7FU10_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">P1B, P type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ATPase1-1B</name>
        <name evidence="17" type="ORF">PHATRDRAFT_10677</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178233.1">
        <property type="nucleotide sequence ID" value="XM_002178197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU10"/>
    <dbReference type="STRING" id="556484.B7FU10"/>
    <dbReference type="PaxDb" id="2850-Phatr10677"/>
    <dbReference type="GeneID" id="7197661"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10677"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="InParanoid" id="B7FU10"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="883" mass="94663" checksum="DFF7271B6864F718" modified="2009-02-10" version="1" fragment="single">LEIRGMTCSMCAQAIDVKLRSVPGVTEVAINLTTDTATVAFRPRDSETKGRLEELTGAIEDAGYEVVTARLMNCENGSSEPRGKAELVIQGMTCSMCVQAIENVVRQDLQNTTIAIHLSTDTAVVDWDTTKYSLETIQETIESIGYTVTSANELPENNSTESTSMEESWEHFTRRQEAKVQAQRRAFLSSLAGTLPILLFTMVFPHILPSHTFLNRHISIWGYDLEWQALILWILATPVQFITGWGFYKHAYFGIMSGKAGMDVLVALGTTASYGYALEGLLTGDDEAAHFFETSAVLICFVLAGKWMQVLAVRRTSEALTALMKLQSKTAVKITPGNKVSSASFNPLFDPYHEAVVPIQEVHAGDMVKIIRGASIPADGNVLFGEVSVDESMVTGESVPVLKGPGSVVLGGTVFGAAFVEVTGVGSSTALAQIVQLVQEAQTRSVPIQSFADRISGIFVPTVCTISLLTYMVWYALCSSKVVPASWYDDLGESMTTFSLKFAIACLVISCPCALGLATPTAVMVGTGVGAKLGVLMKGGEALEVASKVNSVVFDKTGTLTQGKPAITDFVRLDEENPNDWPEDDLLWMLASLERTSEHPLANAVVSYAEEHLSVDYLEQHPFAQPSNFRAITGRGASGVVQGTSVAVGNRSFANVLNISVPAQAEAVMKRLEEQGKTAILAAFNDHAYVVMGIADELKSDAAASLSYLKNTLGVDIWMVTGDNSRTAKAISRKLGLAPNRVISEALPAAKVQKVRQLQAEGRVVAMVGDGVNDSPALAQADVGMSVGTGADIAAEASDMVLVKAHVTDVCVALHLSRVIFRRIQLNLLLSLVYNCLGIPIAAGLFYPYVRTRLPPTVAALAMALSSISVVLSSLSLQLYQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUA2</accession>
    <name>B7FUA2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_44486</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178286.1">
        <property type="nucleotide sequence ID" value="XM_002178250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUA2"/>
    <dbReference type="STRING" id="556484.B7FUA2"/>
    <dbReference type="PaxDb" id="2850-Phatr44486"/>
    <dbReference type="GeneID" id="7197762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44486"/>
    <dbReference type="eggNOG" id="ENOG502QQ7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340536_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUA2"/>
    <dbReference type="OMA" id="EENARAM"/>
    <dbReference type="OrthoDB" id="47355at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06160">
        <property type="entry name" value="S2P-M50_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855017" description="Peptidase M50 domain-containing protein" evidence="15">
        <location>
            <begin position="24"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="16">
        <location>
            <begin position="592"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC49951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="834" mass="90788" checksum="95206306E0421F63" modified="2009-02-10" version="1">MMISRISVVALFNLLVATYHTEAFVPSHHQRRAVIRTTAGTYPSAYSRLYFFGRNKDDDEASEADNTDKKSPFFARFGIGKNENEDDSEDKASEQNSKVHETVAAVATVAKDEVEKEQGFTSGPLPRTSRAPKRVVDANLSPLEQAAALQAQAKKIRLEAEKQDAELTLAKITKLEKEIAHAKRHKESHDDAVVELLQRELQALEAKMRGEAPAPVIRSKPLSNKSESGAVPGTTDIAAKVATRAMPENGFSATVSMAEDPAEALQSLDELTKFIENSPKFMKKALAAQVELDYADVENLNTTEMALRVDKMRRLDFSFSARPKPRFTFEEVNAKKKELSKGWAKSLLDPRLTSAASGNETELALLALEYEYYNKGGMVLSQDQLSEMSQDDEFIAQIVSAVNKSAVDSSIETLFPKCTRKEGQAPTMAQVQRLITDVLPKAKFSSTSKPEPVAGGFVIRGINKAENGDELIEAIDKQLTKYPNLADKLSVLYTNDFTVFASTEVESDEFNFDDVEPILYVTGPNIVREPRRVLLSLTSALGIASSWYLSLYPFLLNPALSKRVDEQLALADANMTPDLTWLTDLSLPLFTTFVSIQLIHEIAHRAVAAFYDIKVSAPTWVPSIFTGITSSVTTFRTLPKNKQAMFDFSVAGPLAGMIASAIAIFIGSQITANQDASLYPALPLEILRQSTLGGGIIESMLGSGALSVPGGALGTQAVAQMMIPLHPVAVAGYISLVLNALAMLPVGTTDGGRIALSVFGRGAKLLVGNAFLFAMLAIGLLGSDLFLFYFAFCIAFQPGNEIPSRNEVDRVDFSRVVVATSAYIVAILALIPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUB5</accession>
    <name>B7FUB5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178566.1">
        <property type="nucleotide sequence ID" value="XM_002178530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUB5"/>
    <dbReference type="PaxDb" id="2850-Phatr44497"/>
    <dbReference type="GeneID" id="7197721"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44497"/>
    <dbReference type="HOGENOM" id="CLU_447239_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUB5"/>
    <dbReference type="OrthoDB" id="46318at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="554" mass="61488" checksum="25A0B01C0813D8EC" modified="2009-02-10" version="1">MIACIRRTQSQNTAEIIQPDYESMVGETFCVAWFHPGGVQEVDVALNVKDDVYVAELGDAFPTNISSQSRTQLKRDIDAPSRRDEVESQIVHNQGPPSMLPIRKDTLFVLLSGKAISFGYTKGFLMDVFRLAMQENDAEDVGFLNTHINLSSPYSPTFAVRGAVVARPESYCMCVLSEGRSNSETEEDESNGELILIQQQEAQISRFCRQQRNCELRREVLPRVIQPSPFTVGRKQRCVQFLNAKGSHAVCMMTPPFDCGPVEGPITIFIIGIATEDGCFVSGLYHRFELGHLHPEDSTIEETEMSPVCMATSLYAAQYIEDTGSPVSYSLNSYNDERSSSNHSSGESISKCNCVMQGSTEKLACTAELEDDAQIVRGKSGPGRWHCYTFVADGCESSIRIDGVPEPMSIQIGTEIRRREVLDGLTIGSDHCFNVSLCCGHGSGGEGEGAIAEIAVFRGILDPLDVQTLEHRLMIKHGIPRPSGVLWNETNFERYAHALYTDPRAPQWTEHVPLRFMARHRSVAWSQRNPVTGRNMQISKIGCHASVESSDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUG1</accession>
    <name>B7FUG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division cycle protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178588.1">
        <property type="nucleotide sequence ID" value="XM_002178552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUG1"/>
    <dbReference type="STRING" id="556484.B7FUG1"/>
    <dbReference type="PaxDb" id="2850-Phatr11084"/>
    <dbReference type="GeneID" id="7198071"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11084"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="InParanoid" id="B7FUG1"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31799" checksum="C187333A7B171D26" modified="2009-02-10" version="1" fragment="single">EVHACQFSSWYATFANLPPNELGRKNVTVPSEILNLPETFRDYLLCDGVQLPAGARTSGMLAMSGVGDDESVWSSDSEAEEVSNELFHFSALNSAIDAAIRRLGGLVAPKLNWSSPKDAIWVNGGTLQCKTAGDVYLLLKSSDFCAFDIQHSWKEVRDGDDTSDETATDCHGAIPLQLVLRKWCNLYPSQEFRCFVREQELVAVSQRQHSQHFEHLVRDQYLIRSLVVEFFDEIIKPHSQSLNNYTFDVYLDKKERVWLVDFNVWGRRTDPLLFTWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUQ8</accession>
    <name>B7FUQ8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_41850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178361.1">
        <property type="nucleotide sequence ID" value="XM_002178325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUQ8"/>
    <dbReference type="STRING" id="556484.B7FUQ8"/>
    <dbReference type="PaxDb" id="2850-Phatr41850"/>
    <dbReference type="GeneID" id="7197631"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41850"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237592_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUQ8"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="437"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="685" mass="75228" checksum="295B95F02460400F" modified="2009-02-10" version="1">MVKVVPLHAADHEESRSGDLVLLQAKEPPKVKAVTFAPVEDSLKQLESAEGGDEIAEEELQARFVQPYVDNPQQAMVKKGLLLMLRDENNKALEFMVTHIDTENDASESKASEVIMGSSTPRLEVGLGYDSVGGLDSAIQLMRELIELPLRFPELWTTAGVPTPKGVLLHGPPGCGKTLIANALVEETGAHVVVINGPEIMARKGGESEANLRQAFEEAIEKAPSIIFMDELDSIAPKRDQAQGETEKRVVSQLLTLMDSLKPSSNVMVIGATNRPNVIESALRRPGRFDRELEIVIPDEDGRHTILKIKTKDMKISADVDLFQIARDTHGYVGADLQQLTMEAALQCIRSNIANMDVDSEEPIPEEILDTLEVTNDHFIYALSVCDPSTLRDNKVEIPNVKWEDIGGLEETKRELQEMVRYPIEHRHLFERFGMQASRGVLFYGPPGCGKTLMAKAIANECGANFISVKGPELLNAWFGGSEANVRNLFDKARAASPCILFFDEMDSIARARGAGGSGGSETSDRVINQILSEIDGMGSGKTLFIIGATNRPDILDPGIMRPGRLDQLIHIPLPDHDSRVSIFKANLRKSPIDEEVNMKQLADATEGFSGADITEICQRAAKNAIRDSITAAHFEASMSKARRSVGPEIVKQYEDFTAKIKQQWSSSGAEAVPLRQKHLFPKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUS4</accession>
    <name>B7FUS4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178371.1">
        <property type="nucleotide sequence ID" value="XM_002178335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUS4"/>
    <dbReference type="PaxDb" id="2850-Phatr44641"/>
    <dbReference type="GeneID" id="7198125"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44641"/>
    <dbReference type="HOGENOM" id="CLU_316550_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUS4"/>
    <dbReference type="OMA" id="HEEPNAN"/>
    <dbReference type="OrthoDB" id="47272at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="916" mass="101650" checksum="5654A38E60048990" modified="2009-02-10" version="1">MNDYADVGVFCARLIRLEITWCCKVPRLAKEVRSGTSEKDSDRLKCERVHTILCPALFRKLTTARLKMDRQSNNGSINATSCRLCHFSGSDVRLGCGCTLHARCVPLSLVISAKSAPLGSAIAASPNQNMCPLCMRAPVSEMHLFAMTIDDLDQAVECRKNSVMKKEHGKAAESFELVQAEASYLLLAHSPMSNGISGEHSYQRTGRWTDEETALTDFLMDAFDKGRLPTPEGIRLNDFLSGLLLCKNSRLTKKMKNAKLSVRSYEFSVDKGINFCIDFQMLSSLESKFLESVSSEPTRLELRFNMTKMWRSHFSNLCLQVGSTLLNASDWISSLETMECRAAQAEESIRKSRRRRMGLALKNDVRAAVVSSTESGVFFSGMPMKKMESSKVTRADSMLSTSNLVSADGSAVENPHGPGDAESLCETDFGSEADFINEMLDGKGQTEDFSKILDDFVTGEPFFQPSNHLRNSAGPFLEEIVAFVEAHNLPFQHVDIWVPSYTVQGRGQPDELRLCHAGHATRSDLDSSLFCQLFEYGEYSTKFSFAPGAGLPGRVYSTNRFSWERHIDQADPSLFKRAGGAKIYGVQTGFGFPLKTNAIGKIVLSMYSTSDVAEDPTVIKCCLENIGQYVPEPKWKLVVEMGDSEKNSSSSDLVLTTPAFDSSNLIHYQHDSSEVNSQLLSVSPLGASEQRSVLKQSPRLFPVQSNALNMRKTSSASMSSHASSELPTDPVEEEHFIATLLGYHMPLAEIPSAREPESSSVAPSLMLPHFMSLRLLLLRAEARRSSRDNELIDVVKKSFRGYSKDQRRTDKDLAFLLVKDWQYLIATMPVDERKPAAKPADTHQCHVLNTPTIKTYSTTGNPVSMPASLGYPDQSKSRQSSFDLSFDLRAAKQRKISSSNEYEAHEHKVSIVDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUU0</accession>
    <name>B7FUU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">transketolase</fullName>
            <ecNumber evidence="6">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Tkl</name>
        <name evidence="21" type="ORF">PHATRDRAFT_50819</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="15">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178656.1">
        <property type="nucleotide sequence ID" value="XM_002178620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUU0"/>
    <dbReference type="STRING" id="556484.B7FUU0"/>
    <dbReference type="PaxDb" id="2850-Phatr41856"/>
    <dbReference type="GeneID" id="7197646"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50819"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUU0"/>
    <dbReference type="OMA" id="EWTTGNL"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000045">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF10">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855352" description="transketolase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="20">
        <location>
            <begin position="403"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="17">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="17">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEC50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="711" mass="77136" checksum="27AD267BF8718D61" modified="2009-02-10" version="1">MKFSSIALATVFFAAKAQGFTGSSIKPRFGVQAHSVLKMSTATETDKMAALATAADEARGLAMDSIAKAHSGHMGLPLGAAEIGAVLYGSQMTYNPKDPTWINRDRFILSAGHGSMFVYSWLNLAGFDLPMEEVKNFRQHHSMTPGHPEFPSSEHNTPGIESTTGPLGQGVSNAVGFAASEKMAEALYNTNDHKIFDHHIFTLAGDGCFQEGVSAEAAAFAAHEKLDNLIVLYDANEVTLDKMAEYTQSEDIIKRYDAYGWETYEIDGHDLETVEKTIAAAKASNNGKPKFIKCNTIIGKGMEETEGTNAAHGEAGVPYVDKAKENLGLPVDEKWFVSAGTRDFFSEVQKTNAAAYGEWQKTYSAWKEANPALAKQLEDSVTDNVMPAEDMIKEIPELKSGAEATRVSQNKVIQEISRLVPHYISGSADLHGSTRNYIDGGGNFGSGLDKTYAGKNLYFGIREHAMGSIMNGFAYHGLFKVSGSTFLVFVDYFRATLRVAALSELNRVSYILTHDSIGVGEDGPTHQPVETVSGLRVIPNLDVFRPADAEETVAAMVHSVTHKKGPTALIFSRQNVAQNDDMDYMARREGALKGAYIAKKETEDLDVIIIATGSEVQHALVAAKDMPGARVVSMPCMELYERQSDDYKESVLPSSCTKRVAMEAGVSGLWYKYASKVVGVDRFGFSAPGDIVMKELGMTAENLASEIASMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUX3</accession>
    <name>B7FUX3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_10893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178396.1">
        <property type="nucleotide sequence ID" value="XM_002178360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUX3"/>
    <dbReference type="STRING" id="556484.B7FUX3"/>
    <dbReference type="PaxDb" id="2850-Phatr10893"/>
    <dbReference type="GeneID" id="7197919"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10893"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603382_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUX3"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="31407" checksum="DD12136B321E8E35" modified="2009-02-10" version="1" fragment="single">MQQKYALLEGLGVGSTSTVHRCVSKQNGQEYACKIIDCQLMEERFQGMMEQFQTEIDALRRLQHPSIIRLYDVFLAPEKIYIVMELMEGGELFDYVVQKGTLTEEEAAGIVRKVTSALVYIHEKNICHRDLKPENLLLKEKPCSGPQLGDIDVKIIDFGLSKAMEEPVARTFLGTRGYLAPEMLQRRDYTRAVDTWALGVIVFVLVCGCLPFDDDSSTVPSDDLVRAKFVLRFPRWARQLSPSAKDLLNHLLDVNPRTRYSAEQALWHPWVQGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUX6</accession>
    <name>B7FUX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_26346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178673.1">
        <property type="nucleotide sequence ID" value="XM_002178637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUX6"/>
    <dbReference type="FunCoup" id="B7FUX6">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUX6"/>
    <dbReference type="PaxDb" id="2850-Phatr26346"/>
    <dbReference type="GeneID" id="7197892"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26346"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_3_1"/>
    <dbReference type="InParanoid" id="B7FUX6"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="15">
        <location>
            <begin position="408"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC50338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="647" mass="73257" checksum="10F4184D12C529BD" modified="2009-02-10" version="1">MSADESLPATGTSGCPQPPWEKPTPAEVTHDPRLWITNSLTRQKEHFLTMDGSSRMVWYMCGPTVYAPSHMGHARTYLGFDIIRRILERHFGYHVTLVMNVTDIDDKIIERAAEQHVGHLQLARRYEAEFHQDMADLGVAPPTTLTRVTEYMDEVTAYIANIIQRGFAYESNGSVYFDVQTFSDTPHMHYCKLAPEQVGNAELLAEGEGKLTQDFVTDKQSPRDFALWKKTKPGEPSWDSPWGPGRPGWHIECSVMASDVLDRLLQHRRMDLHSGGVDLKFPHHDNEMAQAEAECGETQWVNYFVHAGHLHIKGLKMSKSLKNFITIQQALEINSARQIRMLFLLHKYNAQMDYGDNTMTHAMETEKRFVEFFHNVKACLRQHRMDDSQKWDATTIRLQQTLAAAKTKVHDALRDDFDTPTAMSVLVDLVRATNIYVEGDTVVNLVVRNVASYVTDIFRTFGLVGSEDVGFATESGGASREETLGPVLDALMNFRAAVRDKARSQDVGGVLDLCDAFRDLHLPNLGIRLEDKADGSVWKLADPAELLREMEQKEAEATRRAEEKALKASEDAQKEALNRLPPVEYMRQLTLEDNVTLMYSQFDEDGIPTHDATGEPVNKNQGKKVQKLFKAQQGKYDKWIKSQSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV52</accession>
    <name>B7FV52_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179079.1">
        <property type="nucleotide sequence ID" value="XM_002179043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV52"/>
    <dbReference type="PaxDb" id="2850-Phatr44977"/>
    <dbReference type="GeneID" id="7199654"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44977"/>
    <dbReference type="eggNOG" id="ENOG502RRBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080270_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV52"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852673" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="236" mass="26493" checksum="B51645B7469F8943" modified="2009-02-10" version="1">MARLLRLLPLLFFYVAQPANCLQNVIPRLTFPSPMFSINKGKARELEDELLKAIQDEGNRLANSERINSLVKQLENNSQSIPEPAIAAEVYGRWRLMHTTNAATSSPIQRKAVDTAKFPIYQDIIVNEKGQLQVNQIVQFSEKAILSVDALASTAAYPLPEFTDRQSTGEVLGINILGVSLVGEVAQPNPDRPNSRINFVFEEGNFDFDGLKIPYPVPFRLPLLRDWRSCTNRKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVA0</accession>
    <name>B7FVA0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAF6 C-terminal HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179103.1">
        <property type="nucleotide sequence ID" value="XM_002179067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVA0"/>
    <dbReference type="STRING" id="556484.B7FVA0"/>
    <dbReference type="PaxDb" id="2850-Phatr45009"/>
    <dbReference type="GeneID" id="7199678"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45009"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548017_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVA0"/>
    <dbReference type="OMA" id="YASHVTH"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="7">
        <location>
            <begin position="213"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="498" mass="54510" checksum="6070E0E4B5938B91" modified="2009-02-10" version="1">MQTTARHTLVTLVEDHLTVLIADAVTVGRHAKRARTVTNSNSNNNTTNGTPLDEVAAVSKGTSSSTGGGVTVRRRLHAADINLALQMRQSEKLYATALVPPDTVHPSSMSTTTTTDNPDHSLPASHRPVNLADFLRHAQLPFQQPAEVALHVSWLAVDGIAPEPHPHGVVGAWTDRHTPSPHPLAMPHENNNHHNPYQSTAPQAWLVQQLQAAMLSEELQLYFTRVTYALDNTTNTHSPTSARAQDRLLDRLAVDAHLQELVPFFARYVTQTLYASHVTHQRAAVRLVQAMLHNPTLHLELYLHELVPALLTAIVADHRDRTNQRTSVAVTATPHWRLRVEASVALRTVCRQFGPEYPTLQARVLRTLCQALGPDRSRPAVFGGLTAVTLFGPLAIQAFVLPMLPHAWNAWEEEAQSSATEEVQWETRQCQQAALGALGTWLRSYAPTAPQTLTAGPAEQVAATDVAHPLLADTWGDALVPLQGYGPDVPTDYTLCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVE4</accession>
    <name>B7FVE4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178692.1">
        <property type="nucleotide sequence ID" value="XM_002178656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVE4"/>
    <dbReference type="STRING" id="556484.B7FVE4"/>
    <dbReference type="PaxDb" id="2850-Phatr44722"/>
    <dbReference type="GeneID" id="7199855"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44722"/>
    <dbReference type="eggNOG" id="ENOG502T0R1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374069_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVE4"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="80219" checksum="B3E73F9FC8226A3F" modified="2009-02-10" version="1">MLRLTRPLRVSAGSRLKRHEATNTAGLSHNCSTLPLERDDSGNSSLTDMKSSSQIPQRAMRPVMASVSTYMQHSSTNVALTTAGCWPLPPHPLVEAPSLQWQQRAVLPLFNTLVASQTLLSAGNEMRRPILNRLRNQEAISADSSRKLQKGPWLEYFASLGDTSLKEIPAELLETTDPETLSKGSTVSLPSTKTSLPRLERELRGHIDARRVGQAIEVFLRARHSQEKEYHQLNLKLVGRLFDLLCTRRRPFDAYRVLTHYRNLSTAPTNAVPKSETNFVRKYERLCSCLRYMNPTFHDAGSILKLARRVYADLKQMDEKCQRTCLPTFLSALGQQRSVPAGIMCLEIYKYMLVNKFDLKGSYFEHLLGFSKFFRQQDLPYADVLARSVAMGRIPPPAVALNVLENLFPYTDAGATHAALQSIIKLQSTALENGLPQYHLDIATMELISAASTKNGAHKNILLIWDLLDLISCKPSEGLYENTAIAFATDPNMYDDAFLVLAEMEEKGMIPSRALIRGLSFQFRPSEKLLGLACQRWTTLRTNGIGATLSGLNALISASAERGNVYRAFALLEEIPRSNLEADADTYSFAFEALGKSLFRKLPLTTNEPKLIASILEKADSLLTVMESQGLSPTHHIVREYVEVLCLAGKVDVATNVVLDLIASPGSVNSKTAYRVSMANVTAGNFDTARRFAADAGDHTNLILKKIAQEEAKASETKTEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVV2</accession>
    <name>B7FVV2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178997.1">
        <property type="nucleotide sequence ID" value="XM_002178961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVV2"/>
    <dbReference type="PaxDb" id="2850-Phatr44845"/>
    <dbReference type="GeneID" id="7199786"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44845"/>
    <dbReference type="eggNOG" id="KOG2127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003129_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVV2"/>
    <dbReference type="OMA" id="ENTANHM"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="140"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="932"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142889" checksum="F9AA1BBE5DF90214" modified="2009-02-10" version="1">MRVGHTRGRSSRRPAPTGVTPPRMESKDSSKYSKSQSSSPKNRAPRSSSLPKQRRNDPVADTLSESTSAQRLVEYFCIRRKTTEASSWGSSPPKAKGWRQRVRFNGGSMPVHEALHAYPTKSLDGSEEDLASSQATDGNIHMPRASLHHQDHTFQPTITTRYPPTDYADNPLNPMILHFCYPSGDIIVPTRQYQMPRVHHFVLTNEKGRKVYGTCLTILEEYVPRGPWKSRAVTTRHDSLDGVEVSIDDDTNSVLYLPKVLCLLSTWPYLSAFREYLAQLYRLASATNVMTAPIERYVVNLCKEIPAPPPGAYEVQVSILDSTIRFWAPPAKLPIAYVAVPYQILFDCLDTEHILQVWSALVMERKVLLLSSQYSILTICSEIFSSLLFPLRWNHLYVPLLPRMLCPMLDAPVPFFCGIVREDWLYAQQFVSEDIIVVDLDHNKVRFGRAVPRMPSFPTKKIAKLRTSLQETIGHVFWTSRGLEMEYRMMTMNKKSNKRSIDRLRSRTGNGALWVEKLAGLDHAFNLAYTPDSHLLDDTSLLKGDTMQSKWDRVQEAFLRFFVALLKDYRKYLIVPQSNLSSSELPIPSFDLIAFLASQKADNTTFLVEMCMTQQFDDFISRRIYRQGEPDLIFFDESIDAKLNRSRLKLKKVDTPVLQNAKAHKVLTKFSALLPNEVGLPGAKFENKPKPYVYKSWPETLNEGLFSEPRPIPTMIAAEFDRQAMLIQRLRADVDDHTDDSDAILHPTGAEYDPSPEVAAFTVFFFAYSALVGLEWQTYERKCQSIDKEASGNQLSEGTSSDGEKRVDVAQEGKAALPEEEVFNDRNVNTCLSDFSMGLCDSCPSSGIFVFNKSLRFIGDSAEAYESVVENTANHMARLQSQIIVSMETASDVTKPVDILAEFEEAKEVASAQLDLAFEALTTMSLRGLKTDSDAYKSLMEACGRCGDTERALKLMQVMKVDGFFADSEILAWFIAAFAQESAGKIDPPVGTQEVSSDNSLLRKSNRGLDVYSDFLRKKFWPKNEDDNSSLQLVGNDLGEHDDVSTDPGITASDVPCHTNRAVPIFGWFKNQDSNEKRRRWRKEKVKATLETRSMHVTDMLFNQLALGDSLLDFLHPDLVIDTRSDVCPQCSCALSENEIVAGWTSCAFNDYTTECPNCSHRFVPRFSITSSSPTFTGSQGPRTPLYCEFLSPWVLRKALQHVVKGDIGIRGMMKPEWRSGTDIRATIFWNLVVMCRRYRLPFSFLLQGNFQNRIILPRTPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW19</accession>
    <name>B7FW19_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">phytol kinase</fullName>
            <ecNumber evidence="13">2.7.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_34441</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>phytol + CTP = phytyl phosphate + CDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38055"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17327"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:75483"/>
            <dbReference type="EC" id="2.7.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cofactor biosynthesis; tocopherol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.182" evidence="13"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178808.1">
        <property type="nucleotide sequence ID" value="XM_002178772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW19"/>
    <dbReference type="STRING" id="556484.B7FW19"/>
    <dbReference type="PaxDb" id="2850-Phatr34441"/>
    <dbReference type="GeneID" id="7199599"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34441"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058561_3_0_1"/>
    <dbReference type="InParanoid" id="B7FW19"/>
    <dbReference type="OMA" id="SWPIFST"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010276">
        <property type="term" value="F:phytol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039606">
        <property type="entry name" value="Phytol/farnesol_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32523:SF8">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32523">
        <property type="entry name" value="PHYTOL KINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="286" mass="30311" checksum="ABE11CF9C480B11A" modified="2009-02-10" version="1">MAFASPSSKRFVVALFALSSFSLVTITALLGYLPGPQALEGTVLPYAFTLIARDCGAAILCAILGYVFVKVNTHAAEKEWMKPSDSRKLIHTFSAPLYMLLWPVFSTAEGAKYFAAVVPLVNTVRLYLASTGNGEASLARAVSRSGNAKEALGGPFIYTLIMTVCIVAFWRDSPTGIVTLSTLAAGDGLADLLGRRFGTGNQWPGLEKSVAGTFAFWAGSTLTSLGLLSWMVYWDCLALSASVKGALFGIVAGISLVAAILELLPFGDDNYTVSIAALVLSIIYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWL9</accession>
    <name>B7FWL9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179184.1">
        <property type="nucleotide sequence ID" value="XM_002179148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWL9"/>
    <dbReference type="PaxDb" id="2850-Phatr45146"/>
    <dbReference type="GeneID" id="7200201"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45146"/>
    <dbReference type="eggNOG" id="ENOG502SP9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_991971_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWL9"/>
    <dbReference type="OrthoDB" id="45109at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855417" evidence="2">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="31742" checksum="8F5C8B7E628E1F48" modified="2009-02-10" version="1">MRLAYSLLGLIATGCAFSPWIAIGPAQTRSQIALLPPPRHEALISPSRRRAPALALSSKDWDAILAEDDDSNQNGRIPAKPDMQYNPRNIQRQHHNFVAIREAGGPEVTNDVYVPEPNSEVFWFVGKVARISDVSVEQVIARQWPLIEQHAANLRPIELYPSRGRLEIWYAPGDSEMEVAYNRPDLVLQKAFRDAEGADSIKHNLIGFQGEMYQGGEEGFRTRRKSDGSPVKPEIQSPNANELQAPTEDDMERLEKELEGKDINEVYKEQQRRYGNKVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX29</accession>
    <name>B7FX29_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179264.1">
        <property type="nucleotide sequence ID" value="XM_002179228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX29"/>
    <dbReference type="STRING" id="556484.B7FX29"/>
    <dbReference type="MEROPS" id="C26.A05"/>
    <dbReference type="PaxDb" id="2850-Phatr34923"/>
    <dbReference type="GeneID" id="7200280"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34923"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784066_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX29"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="34804" checksum="4E3DD73E4B98885E" modified="2009-02-10" version="1">MREDVTNWNEPPPEDPTFLERIVGDSTADDVRCLRFAMLGCEPNVPYGPIDHTAQLFMDLFSKAALATRPKSCWRIAVKTFDVQKFQYPKDQEEWDSFDGVWIPGSFASAYDRKDWIDQLCETIQQEIVSRERKTLGICFGHQILAHSFPDGTATPVPTGARAGRYVMSTTPEGWSMLGGKDSFDLYFTHGDMVEKLPSNAVSLGGSEAIPIQAAAYFRKNEQSSLETLAPASPYAISFQAHPEFSTSKDLGVYRTLELIMDAMQQRGSLTMDERLAAGEDAHKSYQAVQEDNVQIMVSVGKLLGWLPPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXV1</accession>
    <name>B7FXV1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor IF-1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_11934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179830.1">
        <property type="nucleotide sequence ID" value="XM_002179794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXV1"/>
    <dbReference type="STRING" id="556484.B7FXV1"/>
    <dbReference type="PaxDb" id="2850-Phatr11934"/>
    <dbReference type="GeneID" id="7200706"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11934"/>
    <dbReference type="eggNOG" id="ENOG502S8M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1550537_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXV1"/>
    <dbReference type="OrthoDB" id="1714886at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000002">
        <property type="entry name" value="Translation initiation factor IF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="74" mass="8291" checksum="46E5F985FFAA67D8" modified="2009-02-10" version="1" fragment="single">KDDVIEVGGVVLESLPNAMFRCQIDDAPETQAPVLATISGKIRKNFVKILVGDKVLIELSPYDLTRGRITFRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY85</accession>
    <name>B7FY85_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_45604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179895.1">
        <property type="nucleotide sequence ID" value="XM_002179859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY85"/>
    <dbReference type="STRING" id="556484.B7FY85"/>
    <dbReference type="PaxDb" id="2850-Phatr45604"/>
    <dbReference type="GeneID" id="7200382"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45604"/>
    <dbReference type="HOGENOM" id="CLU_423053_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY85"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="648" mass="74134" checksum="2A57904BF173D691" modified="2009-02-10" version="1">MGLEAMVRSDKEIAPAFPSVGDDRDSDTPSFVQLVANVHFVPRRRVPVMPLVLNRTKTTADIKRTAPPDGAENNVHDETSPTELSASSCTPTATPTRESHVANANIATPDTEEWECDATPLLLRRMRSLDIDWSDTSPFPSRQRPNRLDDDIETASMLSMGSTSFVSSTPRRNPTRPRNPIAVIVTTPDFPSTRCRRASNTNTHSPSDSVFDRLYQHGRAKIRAERERSTQYPSRTTNRSANTFRQRGSSGMSIISSDSPLHPSEDSIYERLYRNETRSPRRLSTWSPSDSSSLQSSTSSWQRRLDYTPPMDVRKRRQRSRLTSRSANSTNASTAEATVNANSVFERLYRREPRPRSNLYSLPIHQRRLPSVNGTKRQITESIGCSAASHPENPSDSELELLAHEISLLTKEGHVTDDGSTSTTTRKDSELSMLAQELALLADGLEDEDSEDMRGFELVEPNLSSTWWIESQIIALQAAWRLRQRRAALNRERKYAITIQAYWRVYQVRKQRWLAFTKILEIQKVIRGYLARQMFRNMINRWNGDRHEVASISVLQRAWRSLSARQKFRGTKLSVLKVQATWRMYVQRTSYQDILERLENESFRSLFGNSKTLHDNDDFIGSHISDRANVDRFQILRTIETKIHERIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY97</accession>
    <name>B7FY97_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179697.1">
        <property type="nucleotide sequence ID" value="XM_002179661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY97"/>
    <dbReference type="PaxDb" id="2850-Phatr45611"/>
    <dbReference type="GeneID" id="7200652"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45611"/>
    <dbReference type="HOGENOM" id="CLU_1196867_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY97"/>
    <dbReference type="OrthoDB" id="51689at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28264" checksum="B8E64986A577794D" modified="2009-02-10" version="1">MDRRCYLCPTCVGTYASMHMDSLRKILNHLLMVMMMCNIFLFVASWNVSFLPIMGFNTVLVAFFLCFQNIVVWLILNNNRISALSFLAPTDFMVGVSLGITVGGAILSFVISSAYRHMSRCDAVQPIPVYEYVCAERKSSMAGIWFWSGLVFWLNFCSSLLLAIGRDELTQQNHYENIGLSMDDYEGHFHQHHQQEHGRNDFLGDAMSGIPPFVGDYSTVPEIRSAMEEAERRASNNKPSVEKAYIQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYR9</accession>
    <name>B7FYR9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_45813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180024.1">
        <property type="nucleotide sequence ID" value="XM_002179988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYR9"/>
    <dbReference type="STRING" id="556484.B7FYR9"/>
    <dbReference type="PaxDb" id="2850-Phatr45813"/>
    <dbReference type="GeneID" id="7200820"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45813"/>
    <dbReference type="eggNOG" id="ENOG502S160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887001_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYR9"/>
    <dbReference type="OMA" id="GVWELRY"/>
    <dbReference type="OrthoDB" id="2015720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855186" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="5">
        <location>
            <begin position="99"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="33607" checksum="9D2BAAAC1D6AE640" modified="2009-02-10" version="1">MRLTLPIATLVALGASSSVSAFAVLGPSSSSHHTAALARTSSKTSSRLFMSEPSDTSTDDTSFIYASDGDSDVVDTESSNYTPTAGEAMVSNIMDMMPRQLGADNVSDEARSAINEALYKLEALNPTTSPTVSPLLNGVWELRYVGGYSSDWALPSPTRQLALFLYSGGYSPGTFALALAQKLPSSVVDVGDLEIAISRQQPRVEATVPVKILGGGESKIVVQARLETKSDLRMRETYESAQLVGNNVIELPQPLQYARDLYVTYVDEDLLIVRDASGVPEVLVRKEKTFSKVWGVEPGQADLDGEGPSGVSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYV6</accession>
    <name>B7FYV6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180046.1">
        <property type="nucleotide sequence ID" value="XM_002180010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYV6"/>
    <dbReference type="PaxDb" id="2850-Phatr35647"/>
    <dbReference type="GeneID" id="7200950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35647"/>
    <dbReference type="eggNOG" id="ENOG502QYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1091692_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYV6"/>
    <dbReference type="OMA" id="ANDDECA"/>
    <dbReference type="OrthoDB" id="200511at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29895" checksum="980923D48E41E6A2" modified="2009-02-10" version="1">MHSNDPHEIAKEDDGEAFDKTTSKGRENGLFQACMKSIRGAHVTSNRLRAGLVLAGLFTDKSIYREVLSMFYVVTKELEEKLDTLKVSDEICQKIASLDYNFSKGYEKDMAVLYGDDWETIIEDLIQKNKVARYYREMVRNMDSGTQLAGAAFVLWGALIIGGGAVAMPRVKNLCGKDAINVFKDVTGPGREERRNNFVALWDSLASPGSSEFEEIVTFSQECMRCNNNIFTSLQRSPWWLNYFITAGVGIGAICIVILQRRMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZE0</accession>
    <name>B7FZE0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180333.1">
        <property type="nucleotide sequence ID" value="XM_002180297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZE0"/>
    <dbReference type="PaxDb" id="2850-Phatr45982"/>
    <dbReference type="GeneID" id="7201048"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45982"/>
    <dbReference type="eggNOG" id="ENOG502RW9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961268_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZE0"/>
    <dbReference type="OrthoDB" id="47938at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="309" mass="36047" checksum="50FF4000802F0658" modified="2009-02-10" version="1">MNQRENRDKETFVYEQPTLTRDTREKRQEGCCSGCRQTFFGLREFGSDSSNPQQLDLHATFAPRGVLIFIWKAIVAIFVIATFVYTLVDSQYRGFYFAYVTNWSLLVSCVYVILSLFNSCCVSHRQHPGERQRIGTITALTWISYVIASHAEPLVTIFFWSAEYTRELEVNFDSLAPHGLVAVLILVDGILINRIPVRWIHYWYLIVPYDLIYLLWTVLHFVFDVGNPNQSDQDPSSNDDAIYQVLQWEDDWEMALVLTVLVFVIGPIFFFLQRRLTMYRFLCGDNRLRLRYIQNNDNVEPDNTGDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G011</accession>
    <name>B7G011_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46089</name>
    </gene>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180598.1">
        <property type="nucleotide sequence ID" value="XM_002180562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G011"/>
    <dbReference type="PaxDb" id="2850-Phatr46089"/>
    <dbReference type="GeneID" id="7201433"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46089"/>
    <dbReference type="InParanoid" id="B7G011"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="129" mass="14008" checksum="CDB11218E769E3F7" modified="2009-02-10" version="1">MNSWDSSQTITTCGKRHAILSSRACGRGVVPSRADCSSVPSGAWSAAYSAVSWDFDGAVQQLLQLSPHRKTLLVRSVQTVLTSAGATVSQFQSPTLFRAALLQFVSQQQVRDQIWRACVDAMHAPENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G083</accession>
    <name>B7G083_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180431.1">
        <property type="nucleotide sequence ID" value="XM_002180395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G083"/>
    <dbReference type="STRING" id="556484.B7G083"/>
    <dbReference type="PaxDb" id="2850-Phatr46151"/>
    <dbReference type="GeneID" id="7201367"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46151"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393561_0_0_1"/>
    <dbReference type="InParanoid" id="B7G083"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="703" mass="77861" checksum="0866AB5727736CE3" modified="2009-02-10" version="1">MPMGNIHDECIAQQVVAPRPYQILTVGDGDLTLSLALARAYGDQIDLTASTLVPDCSTLISTYPNAAAVLQELENRQVSVWYGVDATQIHQRKSQNGKQAFGSGNVWDLILFHHPHLGIDDSEQHTESLHAQRHHVLLAHYLASAKFCVSKPNGRIHVCLCGTQATTWKLGEAARRQGLRSAFTLEPHQIISQTGFPTSVPMDRLFEPSHMPQGWKVHTPEPGFAAPRRYRNGKTGSRHALGKYGYRHRRTHGEWPTAAGSSSSSTDTDVIGSMHYVFERDAAASTPQIATRSHSSDKNNITMCTICDLRFETAHALQEHLATPALPIPPLSMIVAEQRARPLERNRPHANESPLIQTARDPRSSTQNADAAKQNEAIVSTVTSGKRLRWFIQHCISPSRSKRTCEQLIIDGYIAVNGQVVVDSGRVLQCGMTVTVTERFIQDNSTFVPPLEIVAQWGQDIYVAWKPVSIRTAGTFDVNTLERRFSGQMGRSFQSLTKLDTGCSGLCVLMPRNTISESLEPRLLHTFTALIHGSPPNTWKSGITIDIPLDGMRRWRKRPAEDLVSQLIFSEDASLVENRIAKTCAATVHALETTTAEPDGEGLLPPLTTIEIITGTLVSGFCSILSHYFRKQGYAIVGDRFASREYLTLPRAVRNRLKQKICLGCTNVSSYGEGQTASKAVPEKWRVSHWESFCCHGENNRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0T0</accession>
    <name>B7G0T0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_46312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180536.1">
        <property type="nucleotide sequence ID" value="XM_002180500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0T0"/>
    <dbReference type="STRING" id="556484.B7G0T0"/>
    <dbReference type="PaxDb" id="2850-Phatr46312"/>
    <dbReference type="GeneID" id="7201501"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46312"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365423_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0T0"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34746" checksum="7CCB30ED3CA4B19B" modified="2009-02-10" version="1">MIALQPPRHHTRSSGDSFQRSRPAFEKLFIGPVMVFGEMITGGHYLEVLRVGKQLAVGREAAPSYVALHRNLVHESGFFGAFYRGFMPWGLFQCCKGVPVLFVQHESMHHLQATAGWSSNSAEKASGFLGGFAQALFVNPLQKIKVSVVACQNMNAMHPTQAFKTLIKQNGVLSLYDGFAPMALRRSLDWGIRFAVTSEVKNWVIALKVREGQSSELNFWELICCGMIGGALSTATHPIDNIITNSMKPMPVGVPRDFVSVTRRMYRESGIKGFTRAWGINMLDNAYHMAWMYGVGTVAYEWMGKALQSPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0T3</accession>
    <name>B7G0T3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180728.1">
        <property type="nucleotide sequence ID" value="XM_002180692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0T3"/>
    <dbReference type="PaxDb" id="2850-Phatr46315"/>
    <dbReference type="GeneID" id="7201384"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46315"/>
    <dbReference type="eggNOG" id="ENOG502STKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053241_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0T3"/>
    <dbReference type="OrthoDB" id="45827at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="384" mass="44018" checksum="0CD752148ABE4412" modified="2009-02-10" version="1">MCLLTRNTFAVIALLSFCTATALLHIYASASTAFDYSDALYVPQWVTGSVSRATGKCAVNLFGLPRAFRSLVLPSLVENVIRPNALHHCDYFVHYFNLTHEKAGRSGAGGRINPDEILFLKEAVHNLSSESVVKFRYDQEQAFWDQYQPLIDRVRTANDTDGRYLYFPWRDKSYVYTLTTDNIIKMWHSIQSAWELMTEHEGATSKRYDRVAMLRSDVVYMTPIDVFKVNRQPLRTGDKVAVVPAFGRHPVNDRMIMGPRHAVEIWAAERFDRLETHVQFVQEKHPGWGMHSERFINWTIFPTIRNTGTAILEDDYMCFFRARADETVQINDCQDSQERVAASSIMQNLGEDVSERLELVLGRKCLNTTQGSVATRLRCPIEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0X5</accession>
    <name>B7G0X5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_36289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180939.1">
        <property type="nucleotide sequence ID" value="XM_002180903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0X5"/>
    <dbReference type="PaxDb" id="2850-Phatr36289"/>
    <dbReference type="GeneID" id="7201622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36289"/>
    <dbReference type="HOGENOM" id="CLU_530495_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0X5"/>
    <dbReference type="OrthoDB" id="185291at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="5">
        <location>
            <begin position="262"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="514" mass="57472" checksum="1A891EF44B403FCA" modified="2009-02-10" version="1">MGPRKLTVCRLRNIKRALFWAMVGALFPMWYLVRSGVDLRPEYPSRSHFQCQGDSRDTRRCVFHNVVVQDGVFWLEAPDPRDPSAAPPSLLCSTTNGPEKHTKPCDVRFAADAFAWRTLLDATTESRRFATGVALYRLNPGNAYHVLFEDMIPIVANLLDRTGGTAVSYSPGHADVKQHQPRAPWGLFVTDRKITAKAMEDKFWNELLPEVTVVHPTTEVYHVDTLLAGSGVPCSHWGLCRPTNRPVGLFDPPDAAITFRHLVFHRYGIQEEAPNAMSLPRQNPPRITLVQRTTTRRIRNLQEVQDAVKAGTGTVARLVDMAELSLREQISLSHDTDIYVLVHGGALANTLWLPPRALIIDIYPHGFMISGRSALLHSIRKALEPAFAVGHLPFQVENTPGQEILEGPLAPGCVCSAFECQSHVFHTSAWIHIDPDRFQTHMQEALHIWREANYTRPISPEEFRLQNNAEQARRDAAAAAIGAPVCWKKEETEGDNVTSDHGSPPTLKANVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Z7</accession>
    <name>B7G0Z7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180949.1">
        <property type="nucleotide sequence ID" value="XM_002180913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr36311"/>
    <dbReference type="GeneID" id="7201907"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36311"/>
    <dbReference type="InParanoid" id="B7G0Z7"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="133" mass="15177" checksum="632F83D301438074" modified="2009-02-10" version="1">MKLKHVMLFALFLTICWAFLLLFKVMGLLGLKKAASAVPLMVPLIVTTILFSTYINQQHFRVTENLPSRECIKHDLRNGPLFNMNLLKNAYLQPEMQVKEAFPEVSTDRELSLGLHTEDEGQYLTPEPSENGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B7</accession>
    <name>B7G2B7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_13820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181181.1">
        <property type="nucleotide sequence ID" value="XM_002181145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B7"/>
    <dbReference type="FunCoup" id="B7G2B7">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2B7"/>
    <dbReference type="PaxDb" id="2850-Phatr13820"/>
    <dbReference type="GeneID" id="7202136"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13820"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="InParanoid" id="B7G2B7"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32381" checksum="E1B2E94AF3B86F66" modified="2009-02-10" version="1" fragment="single">MNPSEERRTLADIILEKIEEKEAEKRGEVVAEDEGITLPPKVIEVYTDIGKILGRYTSGKLPKAFKVIPSLSNWEEVLYLTRPDKWTPQAMFQATRIFASNLNPKMAQRFYNLVLLDAVRADIQSSKKLNYHYYMSLKKSVYKPAAFFKGILLPLLQDNCTLREAAIVASALQRVSIPSHHSAVAIHKLAGLEYSGASSIFIKTLLNKKYSLPAPVIGSLVRHYASFIEDERQMPVLWHQSLLVFVQRYKNEIKDEARESLRLVMKKHFHPKITPEIRRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2F1</accession>
    <name>B7G2F1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181197.1">
        <property type="nucleotide sequence ID" value="XM_002181161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2F1"/>
    <dbReference type="PaxDb" id="2850-Phatr47093"/>
    <dbReference type="GeneID" id="7202170"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47093"/>
    <dbReference type="HOGENOM" id="CLU_1036100_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2F1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852927" evidence="2">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="29818" checksum="703908416ACF8469" modified="2009-02-10" version="1">MKHRNLNLVFFLILSGICCFDAAVDETALSCAVNESTKYFLSGKDILLPAKWLFGTLKKLTIGPFIEPLAMFTAKVLVVAFVNAEILAYLGLIGDRGEGLYEWALDNDIQVHRWIDKYGLRPGGFVRGRLEQMLTSYKKMSAKARFASAVTTGTAFFPLTIKTTVWLGIVVIATFVVAEMLAFVGLIGDPGEGIDEWLKDGDAEPILRTFRRGTSDLRRILRRKLKISELLSGYINSIKDDFVFWIGYSIGGLACVTLRDAPHSNTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2R3</accession>
    <name>B7G2R3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181252.1">
        <property type="nucleotide sequence ID" value="XM_002181216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2R3"/>
    <dbReference type="PaxDb" id="2850-Phatr47172"/>
    <dbReference type="GeneID" id="7201953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47172"/>
    <dbReference type="eggNOG" id="ENOG502RQ99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431184_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2R3"/>
    <dbReference type="OrthoDB" id="46722at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71553" checksum="AB014D5117AB88CB" modified="2009-02-10" version="1">MATTNDTDDAWGEVFALAEGKDTKVSYGKMEAEADPERSALASRARHKRKRDVVSKSASSPLNEEEAYTAFLESRTVIGSSIPQWIRLGETFTSHAVCKGWAVSRKEYKQGTCRRCRRSAVHHLAEIDPKFPWWCILFVGVRNLRCIAVGSILRQAKEKEGSLEGPDTILRYVGRRIWKELDTGMIHGSIIRFPTLQAKWKIFRSSLHSVLHSKADKEFLDKETAFRWIIHSDAIYYQLYYLQLTRQIPLLPHDADTVRRIPHPSEYFGQSQFATDHQQAKIALRLFLQRTETNTPRASDWTDRFGWTHRSSAKHGHILETLHEYRMLETVLLFDFSGLVSTTETITAWFAQVSPSNQLDQHDTPAPPLWMAWRDSCRDFLCHLYAYATISQSVISQLPSLLSKYGMHQGIIEAGAGTGYIANLFIRAGISTEAFDVHPTNSGSNSSSVHNGYHGATPSYVSVRQGKSSALHKYFSHTFSKALLLCYPPPDSTMAYDALRSFVQHGGSLFVHVGEFRGLTGNSTFEQLLMDDFALLQRFPCLPWGTDAAELTIWRRRKASDNTSKSRLLPCSSCGTRESVQRLRLVRYLTYCSAECAQQHQPSISEHLRWAFLPPMRIDWKDDRFFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3N9</accession>
    <name>B7G3N9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181466.1">
        <property type="nucleotide sequence ID" value="XM_002181430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3N9"/>
    <dbReference type="PaxDb" id="2850-Phatr47240"/>
    <dbReference type="GeneID" id="7202618"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47240"/>
    <dbReference type="eggNOG" id="ENOG502S3NP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269114_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3N9"/>
    <dbReference type="OrthoDB" id="41870at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855693" evidence="2">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="544" mass="58880" checksum="D81135DDF89F7549" modified="2009-02-10" version="1">MAQIAVGIKAFFLVSLCSGATASSKNRDLQEFIAIASYQPRTDVSNQKNIALDQYELSSFLGNPANDDLEAAKAIYERGAFVTPIARLTLTNESGLPTMITSDETLVTGKTANGTEVTGIAYESFNPGEMEISVQYASDAPDSCEVGGLLEPYMHGCFAADGELDIEGERVAYRYDPSTDNYNGRTLQQFSTGASFTFRDPNAGTEYFDEFEKFFDYYGKASYADILIQAAFNKTNTGFRNGNLDFSTYLDGDGQNAAIATATAYMILGMEIIGKLEHAVVQCDLPCETDDCKLDPVHSLDEAVAFWTGVLEDFDQGSGRSNLLYGLADETCRQFRTCGVTGDSTEGTSRVNIDLFQLFRTMQEQLLGNQCIEARASKDRMIPLMFLPLIQATLSNVFLAKSMSFDEVVDGEGAVLAAALLPRLASCNFEDAQRLYLQMRVGQHGVAGYSEVRQALERNYECLGVTCADVGGLYDRDRGEYEAEGAPCGGVAQGGGGTNPGLAVGLFLGGMVAVLLGFVLIRHRRRNKSLGAAEFAVEGDHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3T3</accession>
    <name>B7G3T3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181667.1">
        <property type="nucleotide sequence ID" value="XM_002181631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3T3"/>
    <dbReference type="STRING" id="556484.B7G3T3"/>
    <dbReference type="PaxDb" id="2850-Phatr37436"/>
    <dbReference type="GeneID" id="7202314"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37436"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_4_0_1"/>
    <dbReference type="InParanoid" id="B7G3T3"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="431" mass="47546" checksum="A2340EF32D3E34D9" modified="2009-02-10" version="1">MCRWITLLSADSVSLSDIILAPSNSLVQLSKDASFHPGYSDTNNHVMNGDGFGVGWYHTNVATCPYEESVHPFHTKGFHGSDEHKGSSQTLAAVFKDTQPAWNNANLREICMATRSDCIIAHVRAASKNTGVSQANCHPFKAGRLLFCHNGRIDNFSLIRRAMMAHLSDEAYVAVRGTTDSECIFAMILTYLARDDSGEPSPFVQTTTFGHSRIAAAIKKTLRTIEIMLHEHGLTEGYCTFNFSCTDGESVVVTRFCDKSPDIPPPSLYFAYGNAQRLYSELTSEDPVSFVSQQSSSDDSSLDKADSDNGSDTDSETTYNEKPVLLDKLESRPGRLFPDVDAQTACFIVASNPLTRTHTWHPMPRNSIMWCTRGSPPELRLLRLRSRTASMLRTHLPTKGDLGFSIVSTPPTLKDLEFMNLTESDIVGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3W8</accession>
    <name>B7G3W8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181511.1">
        <property type="nucleotide sequence ID" value="XM_002181475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3W8"/>
    <dbReference type="STRING" id="556484.B7G3W8"/>
    <dbReference type="PaxDb" id="2850-Phatr47296"/>
    <dbReference type="GeneID" id="7202329"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47296"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_630869_0_0_1"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49331" checksum="985780B3290EDAE1" modified="2009-02-10" version="1">MDRRVSRRRSQTSLVVAEEAHAAEDPSALQRIVEYAAVRVLARQFPSRNAHGRSSTEIPFNPYREHIPEFGGVLPFVLRLLKTILLSGLLLTVSLASYWMCYQAAMPSRHSSKLLYFDYTGSALPRLMAAKVPFRPVEDSESSYQGPWALVDLFSKQPHWEAFSHEILPPPTTSTRLLQPKQDYYIEIVLDLPESEHNQMLGMFGVVTELYSRNGTKLALSRRSMRIPHESHWISVVRKMALLAPLLIGAIEETRTVTVPSFRHIVESLDLPLKYILVQVVMPRDPILASKTVEITGGEIWIGKELNSVQEIMRHWFYTCATLGTAVFAFFYLSLFLVLKLVLESVGKPEEPACDLASLPEDEPQDFEPIPVVDDDEPHTIPLRNGTNSSRFVNETERVHRADRRHPQTTSSAYEDANIWEDLNFITPVTPAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4D6</accession>
    <name>B7G4D6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181894.1">
        <property type="nucleotide sequence ID" value="XM_002181858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4D6"/>
    <dbReference type="PaxDb" id="2850-Phatr47641"/>
    <dbReference type="GeneID" id="7202681"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47641"/>
    <dbReference type="eggNOG" id="ENOG502QUWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323294_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4D6"/>
    <dbReference type="OrthoDB" id="45637at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="898" mass="97456" checksum="D191DEDA23872A8F" modified="2009-02-10" version="1">MVACIVLQTTIEPMQEPDWDKFGGVVDSAFDDGHIPETIKAVSSSSHPNYSGTRLVTYPRFHRDRSAQVQVVDNAVSEELADALYQRTVQEGQPWGTYVTMNDIRSQRPASPQRESGLSIDELALHAATTFLTAAMHPELATERYHADANPASPNKDRSSTSMSSLWTTDDSNLAHGVAVWALAADEGSQVPYHIDYAEQIRYESNTIVVPVLAGTLQCSRVNCGMLGGDYAVHLNGLDHYHKHGYKGAKSPVSITSFISSASLGCEDDKNWKVIPYRFNRMICQSGHLPHLSTRIESIGESDTSVTGLYVKLQRVIVGFNVFLRDVGAAVREAPEHSAAFRQRVQERQRQRRPVIQKQQPAQTLSFDMIRKNPKLANLLILAKRQRIKEDLGKAQAVLDKQIIEMLLNCTFTSGYLTISYIMDHCSKQDGAWPNPTDVFVHGLNFCKGSLSFQVISIFSFSLLQSFKAPDVVFTGLRLKEIISLNQPVLVVGIHPHLVVAVVTHSSSRALLSSILVGAFSGTQFVSELAPFGVWRLGGISVVGLHPHLGAVVVAHSSSRVLLTSILVSAFSGTFFVSELAPFGVWRPGGVSVVGLHPHLVVVVVVVVVAHSSSRILLSSILVGAFWALFVSELAPFGVWRLGGISVVGLHHLVVVVAHSSSRILLSSILVGAFWAQLLASSRLSASGDLAVSRFAFSGTFFVSELAPFGVWRPGGVSVVGLHPHLVVVVVVVVAHSSSRILLSSILVGAFWALFVSELAPFGVWRLGGISVVGLHHLVVVVAHSSSRILLSSILVGAFWAQLLASSRLSASGDLAVSRLLVFIMLLLLLLPILARVFFSVRSLLVLSSGRNLLASSRLSASGDWRYLGCDIEFKYKQLFGNSSSNKTILVVNTTSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4H2</accession>
    <name>B7G4H2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182072.1">
        <property type="nucleotide sequence ID" value="XM_002182036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4H2"/>
    <dbReference type="PaxDb" id="2850-Phatr37941"/>
    <dbReference type="GeneID" id="7202858"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37941"/>
    <dbReference type="HOGENOM" id="CLU_714692_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4H2"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="203"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="356" mass="40057" checksum="662DD89329F21F7E" modified="2009-02-10" version="1">MRKWRRVYASLCVAVATTVVLSALSRDVRSTLMPFYNETQKTSLLFDDSSDRVGHFDGLFSDARAYQNIEESNQHRQKYEAKCADESSTQEEIVEILGSWYRPSLDGEVATQQSKLPVEPCRFTFLDFGANVGDSMGKLVDAGIPPCSKKGILAPRIDLEHGFLQPLQKGKGFRKLITWIRTQMEEVSRQLSGPVQPENYCYFGIEGNPIFTNHLNRLQQRLMLTSPRPLRRVHFFTETVGAAKDETTVLFLDTVNEKENFWGSSTLSGHRDVQSSLLSGNDKREVSVQGFTLTRLLHETVKMMPGAHVMVKMDIEGAEYALLNEAFDSGALCNTTARAVRVDIIVEVHGEIQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4P5</accession>
    <name>B7G4P5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_21873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182112.1">
        <property type="nucleotide sequence ID" value="XM_002182076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4P5"/>
    <dbReference type="FunCoup" id="B7G4P5">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4P5"/>
    <dbReference type="PaxDb" id="2850-Phatr21873"/>
    <dbReference type="GeneID" id="7202907"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21873"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403606_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4P5"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.410">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43116:SF3">
        <property type="entry name" value="CLASS I PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43116">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="406" mass="45316" checksum="8A237973FEB91AD4" modified="2009-02-10" version="1">MSSLSTASTSSTTTFTDTELTEVKRDFQSATELYRKNLASTTKLPALQSQIADLETEQSQPDFWDEANTSRAAIVNAQVSTATRLLTRIQAWQEWHGDAQAALEILSQLASEERAMLLDEFRSAIARLREDSDRFELELLLSGPYDHAPARLLLTAGAGGTEANDWVGDLKRMYQRHCEAMGLSCVVQDEQAGEAVGYKSVELLVSGDNAYGWLQGEKGAHRMVRLSPFNANNKRQTTFAGVDVAPDILNQDDDAYWNTIDVPESELEITTMRAGGKGGQNVNKVNSAVRIKHLPSGLQVKCAQERSQSMNKNIALKRLKAQLLAIVQEQRVAEIKEIRGDMVEASWGAQIRNYVFHPYKMVKDQRTGWETSNVQAFMDGDLLEECIGSFLRHKAEEQRKEQIANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4R8</accession>
    <name>B7G4R8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181961.1">
        <property type="nucleotide sequence ID" value="XM_002181925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4R8"/>
    <dbReference type="PaxDb" id="2850-Phatr47748"/>
    <dbReference type="GeneID" id="7202917"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47748"/>
    <dbReference type="HOGENOM" id="CLU_1368582_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4R8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855756" evidence="2">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="200" mass="22242" checksum="F71753260E53B70B" modified="2009-02-10" version="1">MKSLAQIVLLIAVAGPVSSFTVNPLVKTISRPAPLCMAESRTSWRDTTAGSGMQLQHVQTLIDKLNKDNYVVSLEMIEPFLVNEANTDLYEQSMKRIYHKAHNMGLPIPDNYAQDPSRPPFSLHGDDSLDKTAGSGMQLQHVELLISHLSDDNFDVSLEMIEPFLLNEASPATLQRSVEEIKQKAEKLGKEVPESFAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4T2</accession>
    <name>B7G4T2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182127.1">
        <property type="nucleotide sequence ID" value="XM_002182091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4T2"/>
    <dbReference type="PaxDb" id="2850-Phatr38049"/>
    <dbReference type="GeneID" id="7202741"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38049"/>
    <dbReference type="eggNOG" id="ENOG502QZGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1130911_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4T2"/>
    <dbReference type="OrthoDB" id="49185at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="246" mass="28074" checksum="392ED950B89D7660" modified="2009-02-10" version="1">MAVLELKSNRSTVHKRKGEHLNFNDSRAVIVAPSMGRWEACQSKLAALRESLSAESNDAEDDLIAYLTDLKSRNTQAENKIKQTEKEALEIQARLDSQTSEALAACHEESEFLFHLQSELSQRKADRDTLAQELQEYDDEIYSVRDEIAGYKQEISLQLEDAESLEGMRKIQVPRMQQQISLYAMCTGIKWDFAQERRLAGTADVPSQQGLRQFSIDPEEHSSFEIANQLWDMMEGKESSKETHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5J8</accession>
    <name>B7G5J8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_51100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182258.1">
        <property type="nucleotide sequence ID" value="XM_002182222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5J8"/>
    <dbReference type="FunCoup" id="B7G5J8">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5J8"/>
    <dbReference type="PaxDb" id="2850-Phatr51100"/>
    <dbReference type="GeneID" id="7203224"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51100"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="InParanoid" id="B7G5J8"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC46159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="110" mass="11976" checksum="BA424959883495F2" modified="2009-02-10" version="1">MKLVKFLQKLNREQVTIELKNGTVVQGTVVGVDSTMNCHLKKAKVTVRGKNPVPYATLSVRGSTMRSWILPESLNLDALLVDDAPKKSVVPKQAGGPGRGRGRGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V8</accession>
    <name>B7G5V8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PAP-fibrillin-1</name>
        <name evidence="4" type="ORF">PHATRDRAFT_48066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182473.1">
        <property type="nucleotide sequence ID" value="XM_002182437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V8"/>
    <dbReference type="PaxDb" id="2850-Phatr48066"/>
    <dbReference type="GeneID" id="7203421"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48066"/>
    <dbReference type="eggNOG" id="ENOG502SEZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777549_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V8"/>
    <dbReference type="OrthoDB" id="201321at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="3">
        <location>
            <begin position="65"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="32308" checksum="35A30BA894BC3531" modified="2009-02-10" version="1">MMREQRMLAILWGAGLWFGGSGVHAWQFPNLFTVPIQPSQKFSQGSTAKSGGYSHTHTLPGSLQKQAVLDAVSGTNNGKTATPNQQQTVLRRVRELEQSFPPFRLADASQAARLDGIWYLQYTSPSTVGDNNNNNNNNSEDAWQPSYATEGDSRIETRPFQARGTVSAAGIRVDTANKVVQQILDVSNARVANDVVLEWGRVYVAGSFRPSDMVPNRAVVSFDTAEITVAQQGGTEKGWKIQLGWFFWILSKIRGTTENGWLETTFVDDTLRIGRGNKGTLFVLTRDVDAVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G677</accession>
    <name>B7G677_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182528.1">
        <property type="nucleotide sequence ID" value="XM_002182492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G677"/>
    <dbReference type="PaxDb" id="2850-Phatr48166"/>
    <dbReference type="GeneID" id="7203502"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48166"/>
    <dbReference type="eggNOG" id="ENOG502QRDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049280_0_0_1"/>
    <dbReference type="InParanoid" id="B7G677"/>
    <dbReference type="OrthoDB" id="272750at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF17">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855818" description="Transcriptional regulator" evidence="2">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42749" checksum="3E7A852E7EF71E82" modified="2009-02-10" version="1">MTLSRLFQALALVVSMSEAFIGSSRSSRSSFALSSKNSDRAHIERNLEDMMDNDWRLFRAKLVAQEKAQNTANVKESPTVSASSETSAELPKPLPLGVDEKLTKQGQLSEIFAGAISSIFKKDKNVTTNARAVPSSRTSSNEDIFHGDHVGGADFSQISSDPFVSADELPLWIDTSRTPKVDKHRWAHEISHVEPGCVLIANEKLGGVFHQTVVLIIDHHETTGSTGIVINRPMDGDLLKIASEQESSLDLSLKLAFSQARVTYGGPVLTDEFSVLHGFGEVEGSRKLCPGVYIGGSEELMNEVRTLRFDPAHALFVKGHAGWVPGQLTREISKGVWYTAAASSDFILRYAGAPVTEDDNANDLWADILSCMGGNYAKIAGKHKGRGDQRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6J9</accession>
    <name>B7G6J9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_14770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182585.1">
        <property type="nucleotide sequence ID" value="XM_002182549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6J9"/>
    <dbReference type="FunCoup" id="B7G6J9">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G6J9"/>
    <dbReference type="PaxDb" id="2850-Phatr14770"/>
    <dbReference type="GeneID" id="7203371"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14770"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784060_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6J9"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="171" mass="19309" checksum="E3F3D266E95F2B68" modified="2009-02-10" version="1" fragment="single">GKPAIGGPWSLVDLEGNLVTNRSFEGKWLLLYFGFARCPDICPSEMMKVGQVMDTLKKDFPKLYEKVVPVFVSVDPARDSLKALKAYGTDFHPDYVFLTGAPDQVQQMAKKYRVYVSKADESPDGDYLVDHSIVIYFHDDTGDLSDCFTQSMRPSDVVEKVVERMTFTPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6K9</accession>
    <name>B7G6K9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_48279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182589.1">
        <property type="nucleotide sequence ID" value="XM_002182553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6K9"/>
    <dbReference type="PaxDb" id="2850-Phatr48279"/>
    <dbReference type="GeneID" id="7203377"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48279"/>
    <dbReference type="eggNOG" id="ENOG502SMBN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013244_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6K9"/>
    <dbReference type="OMA" id="METRFIC"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="96420" checksum="9E7CDE8CF9B3F715" modified="2009-02-10" version="1">MPAFSSKFGSAARPLPVRRRTMGSGSRRKWTSASPTCWIGMTMFCLVVAYVAVVVVVTRNHIVGEDKSYHEDSPLAAHAPEAPLKSSRKNRLDSVQDTGRKEQQIETLAEKTKRNPFRRQHLENPFGHGVAPDVLLPKDEGDGTDAEPNHLAAKIDPPPETHPSPDFILKAFLEPSSLDEWTRKPLPIRSQAKQHNLREISYPRLNSCSKLIQQWPVDDTPADIDPFLPWIHDVFPTHDGAYVQFVAQNKRRCKTGHKEKDIMAHMQPQVALFQHVPIKRLSKDDGTASETRYRLSSHEEADPDGVVTRFICRFKPSMEETLSEFNFDYDWTALRKRYKNTFSEDDGGIKSIHTSQLLFRCPIPKALQNDIRLGRSVDPKTDWTKYFVDLIPIRTPPRYGPPKQFLQPQYKDFLDNNVTARFDPEHEWGSQHILPAIKDSGRWENIPICQPSLMTYENQKADEDLSALILSTTHAIEPVKKHRLVSCIWASAGYTTRGNRFAINDGQRRLLEWISYNKVIGFDHFYLYDNSGAFSNDTSLKSVADLFPDDVTYIPWPSQICNNNPNNVDSVGERSSQYAAESSCRLRFGPHVDWIGQFDIDEYLIPMGKHSDVLSLLKELEAEDTRIVSFGSWRAWPRRAFIDEIVEINDPEICWHNEPCFHLQIPLKHTMLQAYNCDRQPPGQKKEVMPAEKQLYRPDYVLQHFIHYSAVTTLSEKNESEYVKEGMVWKPRGFPDPRQRFGDELSEALMIHTKAVAIQDTSGWQRMCHVDNLKLPRRKQGLCRLGLPWPKDPAMAAQNGTKEGWAFNCYVNEKVEAQLIPKLEESMRQRAPHFFDLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G703</accession>
    <name>B7G703_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182947.1">
        <property type="nucleotide sequence ID" value="XM_002182911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G703"/>
    <dbReference type="PaxDb" id="2850-Phatr48402"/>
    <dbReference type="GeneID" id="7203594"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48402"/>
    <dbReference type="eggNOG" id="ENOG502S0N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041622_0_0_1"/>
    <dbReference type="InParanoid" id="B7G703"/>
    <dbReference type="OMA" id="PWKCPSW"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="411" mass="46146" checksum="4CAA69C4C26CBE21" modified="2009-02-10" version="1">MRGSKKNLPLSSPPLPQTWSHPKTPPRANPIDAFKSNNSTPVTIAYAISVTGCGSDPITEGGAVLKHSIHLNSIHGAGRYNYALFAIYHPSAVSCALPLKALGYELLEREVFVNVADIKGDFLRNKIEQNGCCGEKELIKLEAYTLTDYPIAVHLDLDVLMLKPMDVVFDAMLQDGVSQSTFQTHSVMWPDDPLPTSINAFFTLDYNMVGPKKQYKPVQGGFLVMRPDLNVYEEFRAIVLEGDFRDGQGWGGKVGPFHGSMTFQGIISYYYNVLHPGQAIELNRCVYNQMCDNPRTGKTVNDVVQGECRTNTETCEDCRERNLEDIVTTHYTLCQKPWWCLSHENDSLQHRLCRKLVHEWYKVRSDLEQSWGRSGRGPGTHETDFFYGYCNKMGKGGYIPIEAPYGTGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7J8</accession>
    <name>B7G7J8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_48523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183031.1">
        <property type="nucleotide sequence ID" value="XM_002182995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7J8"/>
    <dbReference type="STRING" id="556484.B7G7J8"/>
    <dbReference type="PaxDb" id="2850-Phatr48523"/>
    <dbReference type="GeneID" id="7194704"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48523"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494764_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7J8"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="551" mass="59944" checksum="FD4424294F1A8D5F" modified="2009-02-10" version="1">MNRPARPTESSYNRLRDIEGIFWTVLAFLPLVYSQSRWNSIYSFVTLSGVVAELVRPHTADKGEAVATRSMWRLPGNGYTNSVSGRSMAYVLLPLLLQTMDGFSADRETDCGRFGMLIIVGNFVGLAPSVSNLGIAAALMVASDLPVGSSIGFLVTWLVLALTISYVPSLHGVLTQGEWTLITALTTIAIAVFGTWETSDIHEENMHHYVALSGVLACGCGCVTVARWPYCKRPVVIQLAALASIPLIGIELAISNVSNLEVRKFPKLIYWLLAFLRDTEAPTTGVITTKTDPWGLLTETRPRFHWLLYWAVVLAVTLPLAPVSDRISPVITRKWFHVVAILLFAPVTIAAPELLSLSYAVALCVLMVLECIRPSAPTVSRFYQRYLDISKDQSHTLLISHAALIVGCGLPLWISNSLPVPTQPDGDFEASASRRSVQYLLPLWGVWVLGVGDALAAVVGRTWGRTRWNDVIGSPTATHGRTLEGSLAMLVGLLVVMLISVGCLLPDPLDWRTVAVWLPAVIGTTLLEACTTQIDNLVLPLAGAALLLAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7R8</accession>
    <name>B7G7R8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_15160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183193.1">
        <property type="nucleotide sequence ID" value="XM_002183157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7R8"/>
    <dbReference type="STRING" id="556484.B7G7R8"/>
    <dbReference type="PaxDb" id="2850-Phatr15160"/>
    <dbReference type="GeneID" id="7194803"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15160"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7R8"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="14719" checksum="DEE62204C3A62226" modified="2009-02-10" version="1" fragment="single">YIKTTTHNHISRSATIHGSRQVEIKGRTVLEAETAIHGDLALVRIGRYVYVESGTTLRPAPQPQLMIPIDSSTTYIPMIIGSHTIIGSNCMIQAAAIGSFCCIGNNVTIGERVIVKDCCVIADNVTLGPDTVIPPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7V7</accession>
    <name>B7G7V7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183213.1">
        <property type="nucleotide sequence ID" value="XM_002183177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7V7"/>
    <dbReference type="PaxDb" id="2850-Phatr48612"/>
    <dbReference type="GeneID" id="7194822"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48612"/>
    <dbReference type="InParanoid" id="B7G7V7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="374" mass="40453" checksum="57CA57AB6D82C4B1" modified="2009-02-10" version="1">MAENNSSSGIKVFLHINGSPQQSEKYSTNAIRIDRNSRSDGRVELNVLFPSMVGTSEAQLAAALISDAIEQLGRNVDVEMIQLSGLRFSKGGVDGLKAALSIHAFSVKHEVLTDIDFCKKLPGDQDALAAFSSIFAAFKLSGLNLSDNTIAGCVWRFWGSQSNLKETSILKWEMRNCMGRAEAAIVSKALQYETALPWQGLRDMAHDTLHSSGRCLGHLAMEGCNLASDNIASLGLCVRVGLDDQIIKFVSLSLGSTGDCLEWLDLTGNQIGTVGAKSLACLARTPKIAKRLQYLSLENNQIDKAGAVELLDAFGRIGSNKFDLNLKGNPCDMGAVALEIAASQCYTEQQNIDLLKGRDVLRNDIQQAQKNAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Z2</accession>
    <name>B7G7Z2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_15138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183103.1">
        <property type="nucleotide sequence ID" value="XM_002183067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Z2"/>
    <dbReference type="PaxDb" id="2850-Phatr15138"/>
    <dbReference type="GeneID" id="7194842"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15138"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028576_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7Z2"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="36249" checksum="EED48FC35248345C" modified="2009-02-10" version="1" fragment="single">YYDILEVAPDADASAIKRSYYLLARKYHPDKCPNDEKAANKFKDVAEAYQVLSDPELRAKYNKDGKDGLSADKTSVADGGAPKIDPAVLFAFLFGSDKFTNYVGRLASATSAAVGDSPKISAKDARTLQKRRVTRLAIAMIAKIAPYVDACESSSGSTEALEAEWTTEAKELSEASYGHQLVTTIGQVYNIMAVMYEGSTESGQGLPKMSQWAAGKRAKMNNSKAANKNQMDTMKAGFDMVKLQSQLQQKMANAKSDEEKQEVAKEMEESSVGILLRVLWTTTVVDITSTLHEMCHMIFYDQSVEAKTRKHRATAVKKLGEIWMEIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8N9</accession>
    <name>B7G8N9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183375.1">
        <property type="nucleotide sequence ID" value="XM_002183339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8N9"/>
    <dbReference type="STRING" id="556484.B7G8N9"/>
    <dbReference type="PaxDb" id="2850-Phatr48873"/>
    <dbReference type="GeneID" id="7194953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48873"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345973_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8N9"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C RNAse" evidence="2">
        <location>
            <begin position="376"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="90175" checksum="72F7050CF985E45F" modified="2009-02-10" version="1">MRKAKKKKSAASRRNHGKGPPQNATQSSVSWIDDLVFAPVLPQNMGDEAKNTLHRTNVGPRTGIHAISDDNANNNNHTISVVSWNMLAEAYCSPRSHVNLPASYRKVVFDRTARRDRIFAILKRLAQQQQPVIDVLCLQEVDVHLDDALQRWGYAAGRQTPRTRAGGGSGGRVDACAVYVRDHRWQIVAHELVRLDDLATLRSAPHSVPDDRRIGNASNSASATSHLQGLQQGFLRRNAALLVRLRDTSGRTVVVANAHLYWNPGFEYVKRARAFLQHAEEPLIFCGDLNSRPHGAAHTYLTQGFINAKRIAPWYSYGKADESMTNDCETTDDGALYNEAKDDDEPVTHSVLEQTFSALDLNDTNNTSELASPRIRYVLDATLNKLCRWLRILGQDAALETDKEEKSRTQYNGTIPLFDRAREERRTLVTTSTRLMQRRDCPTGAYCLNPSVLPHLEVALVHLLLTHGVVLEPATFLSRCVVCNGKIVKVQEKSRQRQILEGYDAPVLAEEMVVYECDGCQQGYWWCDLPTSSASRVKTQATRLFQVCLQAGVPIDGRVPDLFAHVNVPQEQEQGWDYTQPGSDLLRQRLDVIDWLKDESLSCPFHLESAYAMRDESNNLVGEEIPFTNVTDSFVNTLDYIFFEPKRMELLSRLYVPKSFRELNTKNIPRGHLLPSDIWPSDHLAIGATFALLPRTASTDPSVSLAERTDSAATLQKDHRGVAPLEPASARVTSGSDIDSEYCLPTGAGVGALPIRPTAPVFPRRHKKRCDCGCVPSILSMFEMAELRKQARLAKAQRTESGLNSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G910</accession>
    <name>B7G910_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_48960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183560.1">
        <property type="nucleotide sequence ID" value="XM_002183524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G910"/>
    <dbReference type="STRING" id="556484.B7G910"/>
    <dbReference type="PaxDb" id="2850-Phatr48960"/>
    <dbReference type="GeneID" id="7195373"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48960"/>
    <dbReference type="HOGENOM" id="CLU_363497_0_0_1"/>
    <dbReference type="InParanoid" id="B7G910"/>
    <dbReference type="OrthoDB" id="79762at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="769" mass="85052" checksum="BF0D3163168F15B7" modified="2009-02-10" version="1">MRAVCDSRRCTRTCCLRWLADGNGECTERGIDSRRLLLAIDPYLQQSSSIMMSSADKQSVLREEKGSKRRLSCFLQNLQRKNTKQTQRRRSLPLTRDISRHDADPNRDSNPNGGIPRLETYASTVLQSNEAAMPVVVGDARTTTSTATASTVTHDDSGTPEQEHRTATTPPDACTDSANATDTVAEDEWACPQCTLRNRLRSKRCQACACRRPPSSVDASYLAIPSSSSAPAVTHRRDTRNKSSPSSGTTASLVDAGCDATAARENKGTPPTTSAQNKRKSPDSTKLSSPPKKQKVRQATTNKTTPRSPTTIPVRQTTAAEAPRSLLTSIEESKYHSGTAFQQRQSPQINTTYTSQNTHVWDAARKLTKQQGELIQQQHLSIVDMQQRMAVLSDRHDELVQLLHELRAQQGAPLFSTDPVGSTITPGLDDSRTIAHSRLKKPTDLAFEPSTQTLSQSLSQVSPTIESPILSEGSQTMDPNELSFSQLYSRTKGVPFPPPSPGASSSTAHLTSQDMLASQTVCVTTNASAFASLETISSKANRLSRLQTTEATAGSDYGSSNTHQDSARRDSQLQRKVNNIPLGTATNRKMPTATPGNHSTTWISNRSARTFLKDLDVTDEAASRAKCSEHPTWEKSRNDQRMTRRRTYGGADSRKDALWDDEDGVVGCEHSQKPTFAYQETVRCRAQRQNLPCHDCTECRRFLEILREQGHDLSQTNEPLQYSRHRASFTPPETPADFWELDFIDEKRQREKEEAEQASASMERNKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G916</accession>
    <name>B7G916_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial processing peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_15689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183564.1">
        <property type="nucleotide sequence ID" value="XM_002183528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G916"/>
    <dbReference type="FunCoup" id="B7G916">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G916"/>
    <dbReference type="PaxDb" id="2850-Phatr15689"/>
    <dbReference type="GeneID" id="7195242"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15689"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_0_1"/>
    <dbReference type="InParanoid" id="B7G916"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="178"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48437" checksum="7D49F0C600AA1A19" modified="2009-02-10" version="1" fragment="single">LDNGIRVVSQETYGQVSTVGAVAQVGSRFELPYETGTCNLLEVLGFSSTAQLSGLEITNCLQDWGGTPFVNLNREQSLHCIDLLRPNVEKAVALLAQALLEPQFRAEEIEDAKRALEFQALDMPPELLLGEGLQVAAYGESQQLGQAHFPASTESLNNLSPETVANFWSRQLLHNTPGIVLAGAGVRHDKLVEYADRFFGHMPGPTSSASTTPSPQVAITRSTYRGGQVRIHRPYNPQLEDKDLVRIALALHVDDGWHGDDLVGVCVLQTLLGGGNSFSAGGPGKGMYSRLYRQVLNRYNWAESAEAFTVFYEEAGLWGISGSTHPGRAREMTKVLAEHVLRLASTPVTDEELSRARKMLKNNVLTQLESRLVLFEDMGRQILTYNSRQDMHQVCAKIDAVTADDLVRIAQNSLRHPPTLASVGSNLAYVPQQSEVSEWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G934</accession>
    <name>B7G934_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183572.1">
        <property type="nucleotide sequence ID" value="XM_002183536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G934"/>
    <dbReference type="PaxDb" id="2850-Phatr48979"/>
    <dbReference type="GeneID" id="7195252"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48979"/>
    <dbReference type="eggNOG" id="ENOG502SEDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825042_0_0_1"/>
    <dbReference type="InParanoid" id="B7G934"/>
    <dbReference type="OMA" id="THWITLA"/>
    <dbReference type="OrthoDB" id="46149at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855905" evidence="1">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="337" mass="37650" checksum="82FC89FFB0CD494D" modified="2009-02-10" version="1">MRIPRGGPNVWFGVSWACSFLAFGAAHSRTSSLSVNLPLRLARGGALKTTTSTANSKDDVSAYRTRQQLYLQSRSLLLRQALIGRGLDALDHDAGGGDEGGAKKRAKPVDWDCAVATEAHPKSCLYSFDAETGAKVLAPLDTTHWITLAALNRLRRTDPTKVEPLWHSQYNILSTWWHPSHVFSLYTYLTPLGAFVSFLLDSPLLLASTLLGFVLLSALVTLPVWEHLAQIIVTHPVIWQQWPSWGRFVHAALPLKLLLGQMAWKAVAQVFGRLYGRVRTHLIDWECQILETCIPVTILEDAEDEDDEEYASINVQLFDDDEFDYGDGEESDEFDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9B9</accession>
    <name>B7G9B9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lhcr2</name>
        <name evidence="11" type="ORF">PHATRDRAFT_22956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183608.1">
        <property type="nucleotide sequence ID" value="XM_002183572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9B9"/>
    <dbReference type="SMR" id="B7G9B9"/>
    <dbReference type="STRING" id="556484.B7G9B9"/>
    <dbReference type="PaxDb" id="2850-Phatr22956"/>
    <dbReference type="GeneID" id="7195300"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22956"/>
    <dbReference type="eggNOG" id="ENOG502S212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_3_2_1"/>
    <dbReference type="InParanoid" id="B7G9B9"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855583" evidence="10">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="23399" checksum="923D70F856CCFBC5" modified="2009-02-10" version="1">MMKFAVLTATLAASASAFAPAQSNTRVVTSLNAERSKSLPFMNRPDLLDGSMAGDVGFDPLGLSTIEGVGVDLYWLREAEIKHCRVAMMAVAGVLWVELFGPAPGCEMATAKSQTDAFWQLWQAHPQYIAFGFIMTGLVEMITGIAITTGRESGQRAPGDFGLDPLKIKNNPAKWEKYSLNEVKNGRLAMFAAAGQLMQSWTTHEGAFENLSATFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9D1</accession>
    <name>B7G9D1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183613.1">
        <property type="nucleotide sequence ID" value="XM_002183577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9D1"/>
    <dbReference type="STRING" id="556484.B7G9D1"/>
    <dbReference type="PaxDb" id="2850-Phatr15536"/>
    <dbReference type="GeneID" id="7195307"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15536"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="InParanoid" id="B7G9D1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="313" mass="34482" checksum="22AFD90FFA6C4AE8" modified="2009-02-10" version="1">MSASRQNDDDDDDDPSVLRVALCQLPVTNDKAQNHQTAREYLNRAANQGARLVVLPEIWNSPYATAAFPEYAEQLPDVLAQDGDGHTGVYESPSADLLRESAKEHKLWIVGGSIPERDDDDKIYNTSLVFDPQGNLVAKHRKMHLFDIDVPGGITFFESDTLSPGNTVSHFATPWGNIGLGICYDIRFPEYAMLLAKEHDCGILIYPGAFNLTTGPAHWELLQRGRAVDNQCFVLTASPARTEPPSKAGLYPHYTAWGHSTAVSPWGEVIATTNEKAGIVFADLDLSKVTEMRTSIPIGKQKRTDLYQLVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAL3</accession>
    <name>B7GAL3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184214.1">
        <property type="nucleotide sequence ID" value="XM_002184178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAL3"/>
    <dbReference type="PaxDb" id="2850-Phatr49441"/>
    <dbReference type="GeneID" id="7195924"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49441"/>
    <dbReference type="eggNOG" id="ENOG502T6MJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291959_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAL3"/>
    <dbReference type="OrthoDB" id="48646at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="754"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="842"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="927"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113560" checksum="A912BA828F03AD79" modified="2009-02-10" version="1">MASMLTAMSSLPAKKRRGSNASKSSVEGESSDANEALPSLSQRNNPSDTTAAMASGSSEKSKAESATPRSPEGLHESSNHAKPLKISENRLPSKKRKGSHDSNPQGIHSQSKRKGSQESSSSLRNHLQVPLPALHDSNDCKQSSQRGSGCSEMPFETDHKARKRKGSHDSNTVKFDKDTKVPAERKGSHDASVQFKEDVKSQKRKGAQEKSSTPSIDSAAEQKRKASHDFTESVLLNGVSSSIPGRKMSHDLSVQFVTGFNERKWSQDITIPSFEGVPRKDSYDSSLKLDELLPFPPPEPVSNLRHPSFNTTNTDTPSVLTGVHPTAISAMDHLKALSGANGDTAAVASKNDLEDEDSRSSSTFASSGQRILLEAFPNPSQEGNFSSGNFGSHSDTSHPTGRHRLESWGAMSDLSAPLAGGGCSDSTAAALAHSALQHADLADDVMDAAAGLDSINDLHEAPDAIPNRISLGRERFNSVASLSEVSLSGLLFDGIEVSGDMQAFVSAAMATMGDQLEALAGAVETVANSAGPHALDALRRELGMDSDADSDASPMIGAMSDNGRHKGRPRSWSTSSGRISVDYEAVAAAVDAGEAADLSGVAAIDPSSSSISKERQRHASRRQLPLQRARDDSDLSLNSDERAHLNASLVGSSLTDDEIKRIQERARKKAGYIPPTARSKAENKANKEKTGPFKKRVKRNSPEPAQIRSASPGGTHTPKASNKSMTMSDNLPLVPDLVLSGSTAASKAAKGQASQKWESMFECLVEYVDQCKKEETKGFSQTEVDQWQWDGNVPTSYKSIDGKALGRWVNNQRSAKSKGTLKGEREQRLLDAGLKWSVLTSNSWNEMLEELRLYIKEQAAKGKKWDGNVPTNYQIKNRSNGRFAGEDKNLGRWVNRQRSQFHAGKLRKDRQLDLEKVGLKWSMLATNSWDSMYETLCEYVDQRKKEGGGWDGNVPANYRTNDYPPRALGRWINRQRSAFAKDKLKSEYVEKLSETGLKWSVHERTCSEKDDMDGEDHEASSQPSVKPETVTSTKSNEMAVETIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAL7</accession>
    <name>B7GAL7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184216.1">
        <property type="nucleotide sequence ID" value="XM_002184180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAL7"/>
    <dbReference type="PaxDb" id="2850-Phatr40148"/>
    <dbReference type="GeneID" id="7195926"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40148"/>
    <dbReference type="HOGENOM" id="CLU_1437027_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAL7"/>
    <dbReference type="OrthoDB" id="43696at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="189" mass="20413" checksum="C6AE7C7FAD7CE253" modified="2009-02-10" version="1">MTFSIPATPIDADAGAPLMKSEAHTPLYDLACMLSIGASVAQGFIILLGGSGLPLDDNGATSSPDMSDSDYNLGFLVLTEGNVVDACFGVDTTSSIGVLDLYSPRNRAKDQAKIVKCILAEAGNSSDAVQRKAVDSYRNAFRVCVRFHEKVAQLNFLTYCFKYHQIMYEANVNVQELFVELQEAIDSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAQ4</accession>
    <name>B7GAQ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184236.1">
        <property type="nucleotide sequence ID" value="XM_002184200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAQ4"/>
    <dbReference type="PaxDb" id="2850-Phatr40186"/>
    <dbReference type="GeneID" id="7195826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40186"/>
    <dbReference type="HOGENOM" id="CLU_563207_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAQ4"/>
    <dbReference type="OrthoDB" id="8300686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="463" mass="51791" checksum="28D738B8FCEA4B62" modified="2009-02-10" version="1">MSPPCKYIEFWSGERQNESHKGVVPTSFDQPPAMQTFTRDPVGIEELPFATELDKVNGSTRPGPGQGNTYIAPSENTRKRKYVQDNDHLVTTKMQKVSHNVVVFPTHAPRENTLKRKYVQDNDQLESRKRQKVSHAFVFPATVPHENTSQRKIQDTNLLESRKKQKVHLTFASTVVVRTPMVMTDLQKKRKQRMAKNKQRMALMTGFKPRTWKNEMELFEEQWLQKRQLCAKTDGPTQPVEPEQYTAPDCELTTSLPPPPVDAVVDSVVVAVVDSVVAVVDSVVAGEADDDSSHNTEDEVEATVPEEATTVPEEAATLHWRLPVQQQQQQRRRGNQQVTNARGQEQGPGTEFPSNFALADDANVEDDTFLITGSQAETGRAAGEGCDQDGAETISLFWPGEARGYAFGGKIAWIVSDNRSLFVQPSNHPTVQPSNHPTIQQSNHPTIQSSNHPTIQSSNRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAZ2</accession>
    <name>B7GAZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184161.1">
        <property type="nucleotide sequence ID" value="XM_002184125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr40273"/>
    <dbReference type="GeneID" id="7195868"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40273"/>
    <dbReference type="eggNOG" id="ENOG502S762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693495_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAZ2"/>
    <dbReference type="OrthoDB" id="205028at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="364" mass="39774" checksum="7AE44879B340421A" modified="2009-02-10" version="1">MGFDAASIQQALASSNGNLDQATDALLSRQGSPSNSQSTPSRAEEESLQRAIQESLRTVPLTPHEHAQRSKPTVPRTAAVSKAAQAAARRAATARETVSVTPHSASTSLAIHHPEVRLVPKLQDKSKEEQILRCADRMKASPAAVDTLLRTLSAVQKEPSNDKFRKIDKSTPGYQRSVAKTPGAEDLLRAMNYRLVPSRPNELIIDRSMIDPALLYLGISALEQVKGTPEYQQGKAQLTFTKELATIRASADCSTEEAIRRSTYMGQCPSEPTEGRGALVQIVLVDEVIRRRFDGDDILNDILHWLGGHGSAIPDKLLSRTWTLVDRNANPPSSIDCVANRNNTLQYIGCWPSGKLELLPNTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB19</accession>
    <name>B7GB19_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184294.1">
        <property type="nucleotide sequence ID" value="XM_002184258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB19"/>
    <dbReference type="PaxDb" id="2850-Phatr40300"/>
    <dbReference type="GeneID" id="7198230"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40300"/>
    <dbReference type="InParanoid" id="B7GB19"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="707" mass="78283" checksum="D90794434BB7EEED" modified="2009-02-10" version="1">MTISPQEREARRGVQRENSLGLIDIFGDRAVVDPYATSNQEFSKLASKNPTERRSNNLQGSKSLHDSRTSASLGPNHRRRQMQVESDAIMSGAETEDTCRSSASRIRRSGERVRRSKGRERKAGVSRTRSSGTPRSLEAGLKTTLSHESNQDSAQAADDEMLLELVEHRTKERSRTGLVKVTQRTLSVRGESRSARGYRSSELAPVPRSKSSRVESTDKSSAKESVRLRKIPDIPQDVEHSPPEVHAVAIYRGKARVSKRGPSSVTGHRRRTDSNDSARSHEKPRRSRTRREHTHAYAEKTGAGKGESASPRRRHRSHTHSPVRPPKSPRRHRQLSPRKVLDSPSLAGDEEKFRPRLTLKAPSLKDLSLDEQSPRSLTEAEGAWLENASKGDNSMKQKSQASSEYESEEESTAGRNSNGSVLQFDPSQSDNVYRVKQVTRMDSGLQIGENGQSVDVSIAQLCDPLGDAKPVLRARKELPIFDFLESNDDAMMTFTDTDPMEVSHKAVGLDSPSGGENSDSDGIDVNKFQMHVMSPGVYHSSDEDRREARALRPHTNLTFRSSGGERGADEAILMASPNKELPIYPSGGEEEEEDAVREEDKMDYMVSRKRDLGLPKTMDCESESFDFVSYGSDYASETDRSSRGIRSKSRAKSQPSVLGLSSGGQGDEVGKVRVKKQGQKGRSRQSARVHPTLKRTSTTLENADLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB35</accession>
    <name>B7GB35_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184393.1">
        <property type="nucleotide sequence ID" value="XM_002184357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB35"/>
    <dbReference type="PaxDb" id="2850-Phatr40315"/>
    <dbReference type="GeneID" id="7198194"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40315"/>
    <dbReference type="eggNOG" id="ENOG502RZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1263705_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB35"/>
    <dbReference type="OrthoDB" id="193238at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011719">
        <property type="entry name" value="CHP02058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02058">
        <property type="entry name" value="lin0512_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34784">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34784:SF1">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09585">
        <property type="entry name" value="Lin0512_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="219" mass="23809" checksum="7E1859312EDC3928" modified="2009-02-10" version="1">MPLTDPGKKCTVGRPSERKRNVRATFGKHLRQRDVNLEYITPSNVAYVDRRDGLVHRGLRHSTGLFLGFPEIENCGNVGVNESSDGGSSRNKNTLCGMRLTDRDVCFSLGFGADAHGQNSTKAAVRACRNAIEFNQIPSISDIVPGGRDNMKLDVLLAVPLTYQDGLDLNVIRACFPYGQVRFQIQDGGMVATNGKAIASMGDKNEDMVIVCTAVTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBE9</accession>
    <name>B7GBE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mercuric reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_16069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184357.1">
        <property type="nucleotide sequence ID" value="XM_002184321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBE9"/>
    <dbReference type="STRING" id="556484.B7GBE9"/>
    <dbReference type="PaxDb" id="2850-Phatr16069"/>
    <dbReference type="GeneID" id="7198158"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16069"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_0_1"/>
    <dbReference type="InParanoid" id="B7GBE9"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="11">
        <location>
            <begin position="400"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="57942" checksum="836CA2FED18FB406" modified="2009-02-10" version="1" fragment="single">PLDEYNRTLLNNVHPPGWRDPAVASDKDLYYDMVVIGGGTAGLITAAGSAGVGAKVALIEAHMLGGDCLNVGCVPSKTIIHSANLAHQVQNQTHLAEAGIAVEGHVTVDFEKVMERVRKIRSTISHHDSAERYSKELGVEIYIGWAMFTSERTVEVNGKTLHFKKAAIATGGYPVLLPMPGLQEIYKKAQDSGAVTNESRPQVMTNETVFNLTKRPENMVVIGAGVIGLELAQALQRLGVGVTVLGRSGRVLPKEDEDMGLVVKNQMIQDGVDFRLTVQDYKKIELTGKVLENGYPEMKLTLQEKGNYEPTVLYCDAVLIAAGRAPNVSGMNLEAAKVQFDKKMGVHVNDNLQTSNKRIYGVGDVCSDFKFTHAADFMARAVIRNALFFGKEKMSELLISYATFTSPEIASVGLYEDDLKAKNIAFRVFEKHFKDNDRAIADDATDGWVRFRVNAKTDKILGASIVGVGAGNMISEVTLAMQSATGLGSLANVIHPYPTTAEVLRQSGDLYNKTKLTMTAKKILRGVVKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBU8</accession>
    <name>B7GBU8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184591.1">
        <property type="nucleotide sequence ID" value="XM_002184555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBU8"/>
    <dbReference type="STRING" id="556484.B7GBU8"/>
    <dbReference type="PaxDb" id="2850-Phatr49772"/>
    <dbReference type="GeneID" id="7198450"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49772"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468913_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBU8"/>
    <dbReference type="OMA" id="GESRINH"/>
    <dbReference type="OrthoDB" id="48365at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856056" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="99"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="582" mass="61607" checksum="311076A18669261B" modified="2009-02-10" version="1">MFLALWLFYFTIAVSAEGANRVRRRNVNGAVVANSDEASSVRRHRSDIILDLATTVHTSNFATLDKIPPRKTKDATNDRQLVGWNPADMFQEIQHNPTIVGGGDAEKSDAPWQVMILFWDAANNRWEPTGCAGTLISDRHVLTAGHCAVDNGNRDEGVYVGAYEPFGENPGVPFHFSLIQSHEVHPEFDNRLNDKDAAVLTLTSPVSTSLFPPLQLAGPGFPIRDGDLLKIYGFGRVAEEDASAVETLQVAQVPYISSTRCSRYHSNIRADMFCAGFLDGGVDACQGDSGGPAIRELDGIPYQVGIVSWGVGCARANHPGVYASVAYVHEWIRDTVCASKAVAGFALCAPFGDANPDLHLVPTVTLAPTLAPTVIPTLAPTLLHTLPPTLPPTLAPTLPPTLAPSLPPTQAPALATTVAPTMTPTVTPPRAATVAIPLTRTTAPSLTPTRAPTFTPTPAPALSPPEDATVSTPSAPAVTPTRVPSQRPTVLPLGTTGTSDPNPTRGPATTLFATTGSTTCALPGQSCRDARGCCKGVCLASLAGWTCPVASAERGVSSSSSHKLRVREELVESRKQKKDKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBW9</accession>
    <name>B7GBW9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_30620</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184522.1">
        <property type="nucleotide sequence ID" value="XM_002184486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBW9"/>
    <dbReference type="SMR" id="B7GBW9"/>
    <dbReference type="STRING" id="556484.B7GBW9"/>
    <dbReference type="PaxDb" id="2850-Phatr30620"/>
    <dbReference type="GeneID" id="7198458"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30620"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="B7GBW9"/>
    <dbReference type="OMA" id="VAEGKWH"/>
    <dbReference type="OrthoDB" id="96739at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="66"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="515" mass="56726" checksum="E8ECF582F372DF09" modified="2009-02-10" version="1">MAPPDDYGDDERDTSSPDEETPLINNSASPINERNKSSNKGGGRSNDSTMPRSPSSPITSTLFWTVFIVTLGSSLQFGYGTGVMNNTESVIRAYFENELNQEYTLLQWSFTVSSYGIGGLIGALLGPKVFGRFCGRRTTLLINNCFLLSSSYMIVVAPVWWYQAVGRVLVGIVAGIATAVVPTYLSEISPVAIRGGIGTTHQLGITVGILLSQALSTPSLNLFGSESMWQWLFAVPLFCGLLQCVVLPLCPESPSYLYQHQGKEAARAAIVRFQSEEVADEYLAYIQEEDNEGNHTLTVIQLILDRSLRKQLIVGVMVQLMMQFSGIDAVFYYSSSVFRQADVADPELATTCLGIVNVFVTIFAIRYMDVAGRKTLLTYSLMGMCASFATLTASFLLKPVFPYMDQLSIIATTGIIVCFAFGPGCIAWFIIAEMFPLKGRDSAMAVGIFINWVANWLVALTFPILLKTCHGYTFLIFVATTAYFCFFAREYVPETKGRTIREVTEVFRDIPLSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCC5</accession>
    <name>B7GCC5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_23623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184781.1">
        <property type="nucleotide sequence ID" value="XM_002184745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCC5"/>
    <dbReference type="STRING" id="556484.B7GCC5"/>
    <dbReference type="PaxDb" id="2850-Phatr23623"/>
    <dbReference type="GeneID" id="7198627"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23623"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_1_2_1"/>
    <dbReference type="InParanoid" id="B7GCC5"/>
    <dbReference type="OMA" id="VCHILTK"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="8">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="9">
        <location>
            <begin position="146"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC43840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="300" mass="31563" checksum="819EDE1C81CBE56C" modified="2009-02-10" version="1">MLANLIDGKSIAADIRTEIKDKVAAIASNGGTVPGLAVILVGARRDSQTYVNMKKKACAAAGIVSIGYDFEDNVTEKELLATIQRLNVDSAIHGILVQLPLPAHLDQDKILQAVDPAKDVDGLHPMNVAALQLYSGNALEAPFSIACTPLGCLVLLEKSGIDLKGKHCVVVGRSQLVGLPMARLLLGRDATVTIAHSKTEDIQSLTRTADVVVAAAGRAHLVEGNWIKPGAVVIDVGINSVDIVPEKEGGKTYKLVGDVDFDAAVEVCSQITPVPGGVGPMTIAMLLRNTLRSCERLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCT1</accession>
    <name>B7GCT1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_23709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184938.1">
        <property type="nucleotide sequence ID" value="XM_002184902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCT1"/>
    <dbReference type="STRING" id="556484.B7GCT1"/>
    <dbReference type="PaxDb" id="2850-Phatr23709"/>
    <dbReference type="GeneID" id="7198752"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23709"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GCT1"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="35274" checksum="9E21D56D97E1E31B" modified="2009-02-10" version="1">MSTRSNLQPTSTPPAPTPPTKKHPLQHLIAGGCAGLVESSVCHPLDTIKTRMQLPAAGVVQAPLGPIGTARRIVQREGLLALYKGLTAVYTGIVPKMAIRFVSFEQYREFLTARLGNADKSNATQITFTAGLFSGLTEAVLVVTPAEVCKIRMQSQYHSMMDPTAMQHRKYTNVLQTAMLIVKEEGAGALYKGVVPTMLRQGCNQAVNFTAYSAIKQQVMQWQGTDSLASWQSLLIGGLSGGMGPVVNNPLDVVKTRLQKQVVAAGKPAKYTGLAQACVVIAKEEGVLALWKGITPRLMRIMPGQAITFMTYEAVSAQMTQWGLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD59</accession>
    <name>B7GD59_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_5132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184995.1">
        <property type="nucleotide sequence ID" value="XM_002184959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD59"/>
    <dbReference type="STRING" id="556484.B7GD59"/>
    <dbReference type="PaxDb" id="2850-Phatr5132"/>
    <dbReference type="GeneID" id="7198945"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5132"/>
    <dbReference type="eggNOG" id="ENOG502QVFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817587_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD59"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="23974" checksum="42A14A69DA074DAC" modified="2009-02-10" version="1" fragment="single">KVEGNESQILTVALEPGQVLRAESGAMMYMTDGVQMNTTSGGGLSSGFQRMLTGQNFFISDYSFEGEPGTVGHVALGTDFPSKIVRLNLEEYGGKIVCQKGALLCASHTVDIQMEYSKNMSTGFFGGEGFVLQGLSGEGDVFVKAGGTLIRRDLKEGEQLRISSGCLVAFTNGVDYDVQMVKGFANVFAGGEGLFMTTLTGPGVVWLQGQPAQRMISEIARRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE79</accession>
    <name>B7GE79_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185391.1">
        <property type="nucleotide sequence ID" value="XM_002185355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE79"/>
    <dbReference type="STRING" id="556484.B7GE79"/>
    <dbReference type="PaxDb" id="2850-Phatr50474"/>
    <dbReference type="GeneID" id="7199272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50474"/>
    <dbReference type="eggNOG" id="ENOG502SA2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356639_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE79"/>
    <dbReference type="OMA" id="CCFRSNP"/>
    <dbReference type="OrthoDB" id="192115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369:SF0">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="537"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="747" mass="82494" checksum="F0CE448BA9DB5FCA" modified="2009-02-10" version="1">MMDQSVGWDHEKENVGYFHKHVEKGGLIMASRDNDEANIDLAVLSVPLAEATSTLLELCSSNNTRIVQMEGYVTAKRGFGSSFCFLDLSERGWERRPVQVMLKRQNYSPPMGADSDGNAPTFDGIFRSMLPGTYASITGVASPTRNPGEAVLLCREVDLLGLPRNPQHIRVILECTAKGLLPIASVARLYNQSAEQLQRDLECSGEGCYGKPFDSLAKMVLRSLPADERYPDLVKYKQSFRLPVAPAETYSLPESVKMATKVSVSGIKESAPPLSVEAVLSQFYESEDIDCSGSTLQLPACVHGWIQNRRRFDRNVTVLELVDSLRESDNSTTLESAPHFCQRLKCVSHPQILAVSDTMAHLLAPSAQVQIQGVVIGDKNDGAPTLWITNIRLLQASWWPSVTRFLLELVLEKRFSVPDAALALQVSESEVVEATNANALDLTARQWKAAEFSQALKLKAQEGSSVTCSTEEIFILEKYEAKCADQFPIQDVTNHVSEWLHTPVRGVVGEGKKSRSWFGWANKYWRFYKHTRIGIAHQVSEFRILDVGGGQGWLANHLAQTVPEARIQVIDIASGAVQNGAMRSRRLGLSNNNRVSYTVGDASSPNLTLWEDDFDLVVALHACGGLTDVALSHARSRQIPFVICPCCYRSNAHLQVQASSSSSSSTSSVNISRWLDVAPTTGADEYTILTRLAETQHDLVLSRRATHVVGRLRAAATERDIPNIQVSLWTFPVAFSTRNLCLVGKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEI8</accession>
    <name>B7GEI8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185493.1">
        <property type="nucleotide sequence ID" value="XM_002185457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEI8"/>
    <dbReference type="PaxDb" id="2850-Phatr41555"/>
    <dbReference type="GeneID" id="7199395"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41555"/>
    <dbReference type="HOGENOM" id="CLU_793360_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEI8"/>
    <dbReference type="OrthoDB" id="10674759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="350" mass="39490" checksum="98B421886A266004" modified="2009-02-10" version="1">MDRREYGEGRRRCSPTNWALVEADSMNSVLQDDNKDDDTSASENIQGFKSEWRQSCGGERYSGSAVSRDAFSMPSVLLGSDQDPTSALALDLDQPWQRSLLRELENTDTIHKRPFRSDRMMLGHANSGDFALPIDDDFSVETDTSSTIPTRGKKTQTLCGSSIPSPRTLQEEHDMSSNHWADTPIDPEEYSGEWHCTPMHPPYAFQNDNTTEVSLRPTPKKGPVGRRGSTHDLHYLQRVSAFGDEPQPFQPRWVGLEDDVLTVETSQNEANCMCWGTGILDFLLPPRQNGAPFRGRKRRTYVSPRPQLSVVNEVVEDIMETASKASISRMREEPTGTYRDDQFFYGGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEL2</accession>
    <name>B7GEL2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185546.1">
        <property type="nucleotide sequence ID" value="XM_002185510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEL2"/>
    <dbReference type="PaxDb" id="2850-Phatr50589"/>
    <dbReference type="GeneID" id="7199409"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50589"/>
    <dbReference type="HOGENOM" id="CLU_444456_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEL2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="668" mass="75250" checksum="83BB0572C2D023B6" modified="2009-02-10" version="1">MNRSTAGGPSAIGERQMETMGSPVDDVDAIDMDEEESMPDNFEARFPLSRHIASWRFWWAFAKYPLALLLINTVVLLFLSLYNPENDYQDTYNDDWETSSLMLMMTRFRVKCVGVVVMAFLDTIFLYLAAAFLRKDMHLLVREHQAQDSQAQSAETQSPIWRTAAPLPQLDLKVLDHVHARVAQKVDAYLHRDPAWQSTFPFLVSLLYLLMALAATASLTSVLLLLFVNSAQGMSLCTARDTNVIKFNQTDGVPEDLLDWANEGSSVEATYVRLSDGTLYFRGSAAYIQEPTMLSVYHGMRINGFHSIESDRDSNLRLLASKADGSVSMYSHVSSPTFFASVLEDNSGTSTSFCFLYKEVVQEGYDIDIFPSVPYASSVFSVACIDSKEDANQEVRNTTFSSSNQQELRSCLGRAYDGEYWVRQDGVDRHFWSIQEVQIVRVNPQTMVATTIANKTHSRDFRPVWSREGKCNLRIQEIGYSAAAVFLFIFALAMEQTLKIPSSAGCLAMSIVATLTWIDETLAGLLSLVLIIATAFYLIMGSPSLVVREQMLWGMYCVIILQLVFEFYPVVVFGLGLGIARDHPVLQLGGWIGGPFAVFFLLFYSITDSIDWLELVAFIPLSVLIACGMVTAGNQLTRYRPFLLFYLRRLWRSLCLKIRPQIRQQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7S490</accession>
    <name>B7S490_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_bd36</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176357.1">
        <property type="nucleotide sequence ID" value="XM_002176321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S490"/>
    <dbReference type="STRING" id="556484.B7S490"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft36"/>
    <dbReference type="GeneID" id="7205019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd36"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_2_1"/>
    <dbReference type="InParanoid" id="B7S490"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000055">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="489" mass="55881" checksum="41CB5DA9B9EABB58" modified="2009-02-10" version="1" fragment="single">YVDGTPGPYEITETLRQQSDQVARSRRFHVQKAMRFVWGNYVKYAFGKDELKPQSASGSDQWGGQGITLVDSLDTLWLMNLKDEFWQARDWVRDHLDHSTVGSVSVFETTIRDLGGLLAAFDWSKDRVFLDKAVDLGDRLLRAFDGATTGIPWGEVNLASGNRKNIGWSGDNAIVAEFGTVQIENRYLSKLTADDKYAKKTERVYEILDEISYPDGLYPYYLRNDPRNKGKFLRDGVTIRPEFSNDKLTFGAMADSLYEYFLKTWLQGGRTEPLYRAMYDKSIQGMHDQLLQTSTPSKLTYIADKNRNSGTMDHKMDHLVCFMGGLLALGAYTDPLGLDSTRAQRDLQTAKALTYTCYQMYARMNTGISAEYVQFYAGRDFQIGRGAPHYLLRPEAVESFFILHQLTGDPVYREWGWEVFQAIEKYCKTPYGYGALNNVADVNGKPRDSMESFFLAETLKYLYLLQDPDTEVDVLHKHVFNTEAHPLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4B3</accession>
    <name>B7S4B3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176364.1">
        <property type="nucleotide sequence ID" value="XM_002176328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4B3"/>
    <dbReference type="STRING" id="556484.B7S4B3"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1730"/>
    <dbReference type="GeneID" id="7204810"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1730"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329966_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4B3"/>
    <dbReference type="OMA" id="ANENDWS"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="220"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="870" mass="94589" checksum="7917B52A74E2BE77" modified="2009-02-10" version="1">MSRPAVSVRRDPLSRLQQQEVDARQLEQELQAWTTAPSRSRTSADETRAHRVRVNLCETLADMILTHPAFAAQHGIVGRLWISCFQSKLTALRQLLHQLRRHGKTERADQVEASLEHSLVEAITFYNYIIRHLQDQLLASPAVGSSAGSTAVTGIISNKSINNTSSKNHLPTQDSTPNALEASTLLTVDSSALVGIVSNIAQLELHVGDLFRYAKQLAKASQSYETSFRLAPGHGHAYNQLAVVGQLQQQQPSVSSSSVTNTNTASSPERYQTALAMYGYVRALLATHTRFDAADKNLRNLLATNRGYLHDWQQEQSGLQAPNRVPVSSRGFLLAFVEFHAQLLRRSDQSDGDDGQPQPPSVDTVWTDFGNLLQQNQIGDVLLCKLIAIQAYTEHTTATEQSPAWQKARKATLTMGTALVDRVMAGWQKPKSSSRILVAVLLVAEYLVTTSTVSHSAGSSLEDDEWSHFWKGFLAIANHLKSHMGILPESKSLSLSSCLDGTEEDWHAIKEYQLLRGFKPFAAFLPPCGEGGYLSLEEGAAWLRTEREKKIPSSRKPIERKNSQDTTASSTTSVRAADQGRLKALRFLQLAQQLADTNRANENDWSQRIVCNENGVFEWIEPDSDMQDNNEDDALLDEGTSSENAVGRVLDVTRKNRNPVEEDAKMVESPRDNITLVYQPAPDGGPPLLTPASLDVASTMAGMPIVEPPVHVAATVTSPIHAPPPGLAPPPGLAGPAFRPPPGMVPPPGLGGGPGPSVMEGWWGLNGPPLSGTNHSSVAPSRGNVASTFSPYLFANALETTNPFAVDENQFAGWAMRDVDYDGSGLMDESSLLGPSLLNSIYMDSAGDDVTVGGVAHKRMNAYTKNPFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4G6</accession>
    <name>B7S4G6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_bd598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999287">
        <property type="protein sequence ID" value="EEC42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176459.1">
        <property type="nucleotide sequence ID" value="XM_002176423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4G6"/>
    <dbReference type="STRING" id="556484.B7S4G6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft598"/>
    <dbReference type="GeneID" id="7205132"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd598"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="B7S4G6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="313" mass="34909" checksum="D037DFA63ED3FA91" modified="2009-02-10" version="1">MSSTTSDEAAATEALKSCPTIRLRNGMEHPAIGFGTYKVGFIPASAKCVSDALKVGYRFLECAEFYGNEAEVGKAIATSGVERSDLFLCSKVWTTTIEKGREAISKQLEKTLADLQTDYLDLYLIHWPVPGHHVQAYKTLEIMLEEGKIRGIGVSNYALEDYLELKEAGIKHLPLVNQIEINPFLYRKSTISAFQQEGVVLQSYRSLRDGKAFDDGVLKEIANARQKSPAQVLGRWCVQHGFVYVPKSVKKSRMIENANVFDFELSVEEMTRLDALTTQNAIETFKGLYQKCVNRDTSKDGTLEGVKMNITAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0A1</accession>
    <name>PETL_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome b6-f complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytochrome b6-f complex subunit PetL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytochrome b6-f complex subunit VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">petL</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PetL family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874367.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0A1"/>
    <dbReference type="SMR" id="A0T0A1"/>
    <dbReference type="GeneID" id="4524569"/>
    <dbReference type="InParanoid" id="A0T0A1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009512">
        <property type="term" value="C:cytochrome b6f complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00433">
        <property type="entry name" value="Cytb6_f_PetL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007802">
        <property type="entry name" value="Cyt_b6/f_cplx_su6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05115">
        <property type="entry name" value="PetL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000275539" description="Cytochrome b6-f complex subunit 6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00433"/>
        </source>
    </evidence>
    <sequence length="31" mass="3420" checksum="A939952A95D67E6E" modified="2007-01-09" version="1">MTVAIDYFLLVGFCFAVTSGLWIGLKSIKLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2024-11-27" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0J5</accession>
    <name>RR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein uS5c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>30S ribosomal protein S5, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rps5</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874470.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0J5"/>
    <dbReference type="SMR" id="A0T0J5"/>
    <dbReference type="STRING" id="556484.A0T0J5"/>
    <dbReference type="GeneID" id="4524645"/>
    <dbReference type="InParanoid" id="A0T0J5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_uS5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_uS5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000277027" description="Small ribosomal subunit protein uS5c">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="176" mass="18733" checksum="A45DA34921E5EDFD" modified="2007-01-09" version="1">MSSDLKKINKVKKNSRRISNTQEPKLVERLIKISRVSKVTKGGKKLSFRAIVVVGDENGKVGVGVAKADDVVNAFKKAKTDGRKNLIELPITKALSIPHNVAGNFGACKVIMRPSIEGSGVIAGGAVRIVLEVAGVKNVIAKQLGSNNLLNNARASVCALQNLTTKAQVAKKRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3S5</accession>
    <name>B5Y3S5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_36828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185890.1">
        <property type="nucleotide sequence ID" value="XM_002185854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3S5"/>
    <dbReference type="PaxDb" id="2850-Phatr36828"/>
    <dbReference type="GeneID" id="7204541"/>
    <dbReference type="KEGG" id="pti:PHATR_36828"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="InParanoid" id="B5Y3S5"/>
    <dbReference type="OMA" id="GFWVVWP"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF58">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35239" checksum="66E8B33CB1596D46" modified="2008-11-25" version="1">MTSYEEKKAETLKGSLAGNGGTSQEALFGLAAGAVFGMISPLVGHPFDTVKTRMQAEASYANTGFLQTVMHIYKAEGARGFYRGFIPPLVGSIAFRGLLFSAYSGAYAACEQIPVLHDPLPYTGGLRPSVIVGAMAAAFSRAVIESPLDFVKVRIMVGKEAMLDSSSSKVVKNSMVSSFRLFSASPVSSIRHVYHGFFPTLFRTMGLLGSFFVMVDYSVRYIPDVVNAPVTGPFFKGGVCATAAWVFAFPFESVKSVIQADTTGKYKNLRNSTWVVMRQLHRERGIKGLYRGFAPGASRSFVANGVSMSVYTWFQNYLRTDTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y420</accession>
    <name>B5Y420_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_36927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185763.1">
        <property type="nucleotide sequence ID" value="XM_002185727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y420"/>
    <dbReference type="STRING" id="556484.B5Y420"/>
    <dbReference type="PaxDb" id="2850-Phatr36927"/>
    <dbReference type="GeneID" id="7204720"/>
    <dbReference type="KEGG" id="pti:PHATR_36927"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029148_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y420"/>
    <dbReference type="OMA" id="QKKRTDN"/>
    <dbReference type="OrthoDB" id="47608at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="169"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45223" checksum="81AB0EB23FFAB28A" modified="2008-11-25" version="1">MTASANSMHKYNAHHMVRELAEHNDFFDMLVDMIPSKLYIAGQSGDDYNPNAKYLKKTATDSKEARRAQAKQAKRRKLDPTQAVGTVETKKRLAEQNEFHQNQVLPTIAVPAAAVTPRKGSVNSSSETAVVSPNVSRMDELRARLHAKLEAAKRQRPNTTATTPDAVSKRAARRAEKRRRQEEARHKAAASKSVVKSNSSSKYTVGRDANIDMDPAADLANLDFGRLAGLNSHTKEHYSKSNKALANLSKTKNLERMLADAEAKRERIEALKACKDESAQAEARQILWKDTLQEADGQRVKDDPMKLKKALKRKEVKKAKSKKAWKSRMENVSDAAQSRQKIRQHNLSARKAGGQSGANLSKKKIADAGEDGGRRLSRAGFEGRKQDFLNKGPAAKAADKPSKGKNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4C6</accession>
    <name>B5Y4C6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_43799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185989.1">
        <property type="nucleotide sequence ID" value="XM_002185953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4C6"/>
    <dbReference type="PaxDb" id="2850-Phatr43799"/>
    <dbReference type="GeneID" id="7204160"/>
    <dbReference type="KEGG" id="pti:PHATR_43799"/>
    <dbReference type="InParanoid" id="B5Y4C6"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="149" mass="16832" checksum="5FDAEE3AA8D1B890" modified="2008-11-25" version="1">MKVNGSCLCEVIRFSATLKQKHVDVCHCDMCRKWHGGMGFSVPLTEPPTLLSGKEDGQLSLYQSSEWGQRLFCKTCGSCLFYQAPDYGYYGVVPGVLDEEDQLEEMKLEIFTDQKPSYYYDFAGDTKKMTRAEFLASLESKDCGGEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y572</accession>
    <name>B5Y572_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_7646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186135.1">
        <property type="nucleotide sequence ID" value="XM_002186099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y572"/>
    <dbReference type="STRING" id="556484.B5Y572"/>
    <dbReference type="PaxDb" id="2850-Phatr7646"/>
    <dbReference type="GeneID" id="7204006"/>
    <dbReference type="KEGG" id="pti:PHATR_7646"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_3_1_1"/>
    <dbReference type="InParanoid" id="B5Y572"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="14203" checksum="5531B30954733BA3" modified="2008-11-25" version="1" fragment="single">IQRLSPHATLPRRGSDLSAGLDLSSAANLTIAAGDRALVPTDLAVACPPGTYGRVAPRSGLALKKGIDVGAGVIDADYRGPLGVILFNWGREDFEIRQGDRVAQLILESIVLPDVVEVQGELDATERGVGGFGSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5E0</accession>
    <name>B5Y5E0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_10497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186171.1">
        <property type="nucleotide sequence ID" value="XM_002186135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5E0"/>
    <dbReference type="STRING" id="556484.B5Y5E0"/>
    <dbReference type="PaxDb" id="2850-Phatr10497"/>
    <dbReference type="GeneID" id="7204042"/>
    <dbReference type="KEGG" id="pti:PHATR_10497"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_1_1"/>
    <dbReference type="InParanoid" id="B5Y5E0"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="275" mass="29920" checksum="793DD1BF4476AD5D" modified="2008-11-25" version="1" fragment="single">MDWSALPSTSWVCVEMKAVPWNPADMNSVQGTYAILSQSHFSPKRTVAGSSGIGVVSEMTASKDNRFAVGDWVTVAQPGLGTMRSSVWAPASSWIKISRGSELFEKHGDGISTIFQLGGTALRMLRDFQVLRPGDCVIQNAGNSGVGWMASQLAAAHDVSMVSLVRRGTRSAEKEDLCDQASLQDFRRELQLVSHRPRVLALNAVGGDSAGKLVKLLDRHGTLVTYGGMSMKPLSISAGHLIFQDIKVVGYWNSRWMLQHSLSQQQAMTDELVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5S3</accession>
    <name>B5Y5S3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_33610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186516.1">
        <property type="nucleotide sequence ID" value="XM_002186480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5S3"/>
    <dbReference type="STRING" id="556484.B5Y5S3"/>
    <dbReference type="PaxDb" id="2850-Phatr33610"/>
    <dbReference type="GeneID" id="7204061"/>
    <dbReference type="KEGG" id="pti:PHATR_33610"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_1_1"/>
    <dbReference type="InParanoid" id="B5Y5S3"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="189"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="81291" checksum="533AFF10ED162224" modified="2008-11-25" version="1">MALDSRELRFLSGSFAEFTSHCRFASSSSTIASVLASGAAAAIEYENSFYRVSEDSRRVPPTSQQRQAQPQTQRRNTHTKSSSSSAPGISALPTQPRQGYGPSIQLTEEERALFTLLRQVRSETKLDTTLRVAGGWVRDKLLATPEFQTYHKVLDVGSQRLTSKFQKPSAPSMGRQGTKVLVNTDKDAQPVDIDIALDDMLGREFADRLNEYLSMEGQDTIAVGVVLKNPEKSKHLETATMKVGSFWIDFVNLRAEEYTQASRIPDLMRIGTAAEDAFRRDLTINALFYNVNSGQVEDWTGRGFDDLRKGVVATPLPPLTTLLDDPLRALRSVRFAARLRFTMDDELVAAAKDKSVRNALAQKVSRERVGGELDLMLRSPDPVGAMRLLINLRLIDTVFPIEHYLAPDKTTSTATLFDKGLELLSTSHDHLADCRWSPPLWCKNSRAAFGAVEHRLLQDEEARRLLWYAAFLKPIHDRTPVRQASNPKLTGRKANRSAVAKLLVDKLKRPTRDAEAVERIIKASTDFTQLVNAGCDISATMILLSDVRITYVASCDEFDKSEGLTGSLIGTMNGRLVDSAVEEDPVWQHAMEFRMLCAKPLQRVGPLWRASLFLSISEAMATLEDGFTRLDYTIEGDVFDEILEERRQGVIERYDAFATALQQTGLIGIWDQPPLLDGDTLKTSILKGIPKGPAFRDVMDEQSNWIITHPGADVAALKTHLQETFPEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPG2</accession>
    <name>B7FPG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_6580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177205.1">
        <property type="nucleotide sequence ID" value="XM_002177169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPG2"/>
    <dbReference type="STRING" id="556484.B7FPG2"/>
    <dbReference type="PaxDb" id="2850-Phatr6580"/>
    <dbReference type="GeneID" id="7196389"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6580"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779561_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPG2"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21816" checksum="EC0982FEE13BD32D" modified="2009-02-10" version="1" fragment="single">GYFWMLKDLRTCEDKPLLTSPSLIPESRARPFPNLCNLKSLSGETVDVPDYFVRKNRSRDTQAQCTLVAISFRDYGYQLLSSWIDPFREALQDKDRVEVIRLNISEGFFNKWILKGPVQGLMKKNTPVEEHDRTLLYFGSDLALFKDALRMHNVMTGFVFLVDGVGRVRFAGSGKASEDEAARLVRMASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPN4</accession>
    <name>B7FPN4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176744.1">
        <property type="nucleotide sequence ID" value="XM_002176708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPN4"/>
    <dbReference type="PaxDb" id="2850-Phatr42816"/>
    <dbReference type="GeneID" id="7196175"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42816"/>
    <dbReference type="eggNOG" id="ENOG502SUSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FPN4"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="324" mass="36105" checksum="11D48001A03DF1B6" modified="2009-02-10" version="1">MLMTTKMKAMAGQITLLRGGCLFGSPCCFFIPSRLSLELRASRSQSTSTMDLVDSKECTPLTSTLHFYEKRDFDPSLKSSPKICKDLGKSNWHTLLNASASRSLPFIVESCELDLIQAAKDRDYYDKIVLLVSCCELDIPRDSHEESTLSGRGVGQALSLSRRTANFCNRETGFLPELILVPPLRCIIETAMFSFPQSSPHSLSAAEWICHPHVQDIVAHPSKPGVSDPQPLVSAKIEILENTDSLLQWIQKRSERVIVGKLNCCLGPWYAATPVVSYLIGFFYRLTVASDSPWLQAFSCSLRYSRGAECFREGELRAVGLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ18</accession>
    <name>B7FQ18_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177315.1">
        <property type="nucleotide sequence ID" value="XM_002177279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ18"/>
    <dbReference type="STRING" id="556484.B7FQ18"/>
    <dbReference type="PaxDb" id="2850-Phatr42926"/>
    <dbReference type="GeneID" id="7196552"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42926"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034893_0_1_1"/>
    <dbReference type="InParanoid" id="B7FQ18"/>
    <dbReference type="OMA" id="AMISKCE"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="286"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="48172" checksum="3547372EAA59EFA9" modified="2009-02-10" version="1">MWSGGDDLNENGERVRLYQPILYGRKPVQEDPTASYIGGDDDNQFPLDGTTATCSSCQNSLQLLAQLYVPQYRTAHGSTPVAKTLQISACRRASCWNQLFTEGKISDGQGVVRCRRLCRDRLDYCREKFQASRQQETTLPSRTDSPSPHTNTIAADDWAVPADVTEDNSLGDLEVQLAALEAAEGSSRKPAKPWKRTRPQQCASSKFSCFELSHVQEPGAIAPLDDEDDVGLSKTDDNAKIQAMLARYLAEEDDTDIINALRPSMNTGGGSTWTATEPDERLSVEDRALWTFTDRLQRSPRQVLRYALGGVPLWSIPVSVALSSKVLSTPPIPACVCGAPRVYECQLLPSVLAILRVDQPQHESIWGDALDFGNVAVYSCTAACADADEEFVVVQQSVDAWPAEGVDPRRNDDATAAVVIPEDARFSVDDDDDDEQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQC8</accession>
    <name>B7FQC8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177378.1">
        <property type="nucleotide sequence ID" value="XM_002177342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQC8"/>
    <dbReference type="PaxDb" id="2850-Phatr43020"/>
    <dbReference type="GeneID" id="7196230"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43020"/>
    <dbReference type="InParanoid" id="B7FQC8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="30128" checksum="F08173C25E1B2B91" modified="2009-02-10" version="1">MSVPSASQTVRRIRAVTKNPACIVNLTIDAVNENAKSDGRLSFLLPDEGLESLCSAPPPLEQVTVCSDDDLSSVSSGSLKNYESIHLPLDQQDRQQQPRSIFKKYWDDKGLIPLPIRRVRVSSPGSTMLFRTETAIEEDSASIRDYNTYERTLKAYEEVPSIRRSVGRRSIFDQGCYTASRSTPSFHLRPNHSYNIRKAKSTSILQTRSCLRPSRFSLQKSGSDDSQFQRQQGDKARSVSFSSSIRIALFEPPAERWAENGWSKWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQD4</accession>
    <name>B7FQD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176854.1">
        <property type="nucleotide sequence ID" value="XM_002176818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQD4"/>
    <dbReference type="PaxDb" id="2850-Phatr43026"/>
    <dbReference type="GeneID" id="7196831"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43026"/>
    <dbReference type="eggNOG" id="ENOG502RW6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505797_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQD4"/>
    <dbReference type="OMA" id="FTDICEM"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="52981" checksum="DCC81D0CD632D21B" modified="2009-02-10" version="1">MAAPASTPSGSASRDATKEDFGQPDPVGVSVQPAPGNLKAPPPAPPVVTKRHEPSYGDSEGSDHYTVAKSLLNDGDFENALATIEEGIEKTRNDLEAHDPEADPDRLALHPAMAPFHYLYGTTLLYSIEESTDTQAMAMPHASAEQEPQGGDTNGPNDGQHTDLPTEEVADEMQIAYENLEAARVIAEALRLSQPENTKLQLDLAQIFLREADLQRMNGQYDAALQDYTSCLSLRQSLPEALLGPYDRKIADVHYNLALVYSLAVAEAVKPTDDPHALQQHNERLALYRKRSCHHYVTCGRILCGQIAALAGQDPDTFLQKALDDLPSFKSTGEEDGANDENDHPKLASLKLQTLRRHAAQAATSMTSLDAQETAHELLDLLQEIQETIDESENSEQGVQTVASMKAEISAAVAAQPGDDDEEGAGTALGLEDSNACTATTTIGFGSSAASESTEAVIPLLAVRKKPKRTADDAKLPALDDSRKKTSPSNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR15</accession>
    <name>B7FR15_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177500.1">
        <property type="nucleotide sequence ID" value="XM_002177464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR15"/>
    <dbReference type="PaxDb" id="2850-Phatr32390"/>
    <dbReference type="GeneID" id="7196584"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32390"/>
    <dbReference type="HOGENOM" id="CLU_1047523_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR15"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF61">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28979" checksum="B6B18A1A727F8A78" modified="2009-02-10" version="1">MPASAPADNHNNNNKDATVTPPPGLPKTVYLIRHAESEENRRIGSVKNVFTSLRSFSFPSRLDVGASLELVNVAAQIDSPVSYLGKAQIATMAQQLKQADFVKLSDIQLVLHSPLERARQTCLGLLGCVAPLKATTDQHHDEAIPDLPRVAQVDLLAEKTPSEWVPGNAGALTARVQAFQDYLRAQPETSVAVVGHSQYFKHMLGLDFKFANCDVWKVEFAADDRGPPATVLVDGTTYTLPPPWSNLQRLYVSDPIPPPAKEHAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR48</accession>
    <name>B7FR48_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_43249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177518.1">
        <property type="nucleotide sequence ID" value="XM_002177482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR48"/>
    <dbReference type="SMR" id="B7FR48"/>
    <dbReference type="STRING" id="556484.B7FR48"/>
    <dbReference type="PaxDb" id="2850-Phatr3969"/>
    <dbReference type="GeneID" id="7196599"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43249"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR48"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04238">
        <property type="entry name" value="AAK_NAGK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000004">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852536" description="acetylglutamate kinase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="10">
        <location>
            <begin position="61"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="330" mass="34470" checksum="8937DE7B594DC9BA" modified="2009-02-10" version="1">MQFSLWLSSMLLFSANFVFASAFVAPFRTPFLRFSALQVADSFADSALTIADAAATLRGETIVVKYGGNAMTSQDLKDMFCQDVAALQNLGIRVVVVHGGGPQINAMLEKVGVESRFEGGMRVSSPEVVEVAEMVLCGSVNKEISSKICSAGGQAIGLSGRDNSLLQCTKQINKDGIDLGNVGAVKTVNTKLLQDLLDMGICPVVSPIGTGIDEECDVAYNVNADVAAGRIAGELKAARVLFLTDIAGVLDKEMQLLKSLSVKDIEDLIEDETITGGMIPKVSYATSAVQLGVKGAFITDGRVPHALIKEVLGGGSDGMGSGDGGTVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR97</accession>
    <name>B7FR97_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177003.1">
        <property type="nucleotide sequence ID" value="XM_002176967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR97"/>
    <dbReference type="PaxDb" id="2850-Phatr42432"/>
    <dbReference type="GeneID" id="7196619"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42432"/>
    <dbReference type="HOGENOM" id="CLU_673482_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR97"/>
    <dbReference type="OrthoDB" id="52855at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="409" mass="47640" checksum="77206B834DA2EE19" modified="2009-02-10" version="1">MRRVLEQRSLARFSQRLRNSAYDSNERARLTANEFANSGRKGLNQRPLSTTAQSTDVSSQYKSPLIHHESNDWRDWFSATEYANPWDAEESGLHTLEHVPLDIETRHIVQLLHELYLFGQPTTNNRVTTERCNHTLKHMFSIPIEDRADRADAILKRMELFDNLKPPSQCGRWPLEVPRPNRETYNLVLQIFAKTSGTRELAERAEAIVQKMEWRYQTLGELDMKPHAFHWNCVMLTYKECTDWDKSLYAAKLVLERLRHDPTVFDPSLFVNLLRVFAHRHVNEKAALLGANLAIKVWQDMIEDNSFELPELPSHFYGHFLQAIRCLPEENQFRAQYFDACFLRACQEGKINRIVLDEFLTHVRSRKVSDKHIGIYTRKTFALSKTDAVDAILEMMPDSWKANAEVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRA6</accession>
    <name>B7FRA6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Atg6 BARA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_31423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176511.1">
        <property type="nucleotide sequence ID" value="XM_002176475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRA6"/>
    <dbReference type="STRING" id="556484.B7FRA6"/>
    <dbReference type="PaxDb" id="2850-Phatr31423"/>
    <dbReference type="GeneID" id="7196625"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31423"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024219_1_0_1"/>
    <dbReference type="InParanoid" id="B7FRA6"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="199"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="40179" checksum="B7812BCD4E3C372A" modified="2009-02-10" version="1">MDDRTLDCEVDLQLERTAAHIRRTSVAEPRAAIAGSDRFQDDLATCSDEESLRRKLVSVRRRRLQCHRLLEQAEAQQNALDEQLLAVIRQRDEAVLDYRSVRIAIATQQRQLQISRQWNVTNDTFHIWHSGPFVTINGLRLGAEAPSMEVGSSADTDRQPNGPIEQPRRYLGFGAQPAPSTVNPSSNSNEVRNQEGKNTIRIHWTEINSALGQVCLLLSTLEQKQCCGIRYRHEIVAQGSTSKIGIRSINNQHTAYYNLYSDDSFQLFGKRNFNTALQALVQCVVDAADAVQARDPTITLPHALEKTNTRSGDYVVGGLSVAYGTDGVEWTRAMKYLLTDIKQLMMFKPFALRHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRQ3</accession>
    <name>B7FRQ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_42559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176581.1">
        <property type="nucleotide sequence ID" value="XM_002176545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRQ3"/>
    <dbReference type="STRING" id="556484.B7FRQ3"/>
    <dbReference type="PaxDb" id="2850-Phatr42559"/>
    <dbReference type="GeneID" id="7196097"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42559"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1104549_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRQ3"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="245" mass="27121" checksum="630AACAD9674B359" modified="2009-02-10" version="1">MIRCAANRLLLHQGRLGLLQHSKASTSLLRWNQLRWQPSMLRTLSSDASQKGGNEKKKSEGEDTTSEIVLTPGQKVVEASRLTMWGGIAVFAACCAYYIGRELFPTKMSPNRVFDRSFAAIRADSEVQRRYGDNLKAYGRDHGGHREGRRNFIEHTEYTDAEDGSKRTRVRYNLEGRFGTAFVFAEVSASMPSGEFVYILVQDKSNGRVHTVVDNRAALTAARLASGSKEAQSAMSQLLGGGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRS2</accession>
    <name>B7FRS2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_9860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177544.1">
        <property type="nucleotide sequence ID" value="XM_002177508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRS2"/>
    <dbReference type="STRING" id="556484.B7FRS2"/>
    <dbReference type="PaxDb" id="2850-Phatr9860"/>
    <dbReference type="GeneID" id="7197069"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9860"/>
    <dbReference type="eggNOG" id="KOG1034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488765_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRS2"/>
    <dbReference type="OrthoDB" id="48792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="318" mass="35917" checksum="EC68C3830DEFA822" modified="2009-02-10" version="1" fragment="single">CPKSGTPQMVQAYLDDDEQEDFFCCAFAGRSLLCVGGFRRGIRVIDVHRNRLLATLVGHGDQIYDLQVCPVDEWVLASASRDESIRVWNLRTCTTVAILGGHGGHRDAVISVAWHPLGHYLASSGMDTTVKLWDVREPTTTSQAIAVSHRQARRAFLRNIQELTEPARQQFPIFSTNQVHTHCVDCVRFVGDLILSKSTENKIILWKPLLTLENTSSSSLSSILLNPPQEILHLRTFEYTHSDYWYFRFATDPMGKYLAVGTGKGQIFVWNLAEHKRPAEILSLRYPDTQLIRCVSFSDDGQILVASTDNGVLWKWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRV7</accession>
    <name>B7FRV7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32511</name>
        <name evidence="4" type="ORF">PHATRDRAFT_35853</name>
        <name evidence="2" type="ORF">PHATRDRAFT_39905</name>
        <name evidence="3" type="ORF">PHATRDRAFT_47693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177564.1">
        <property type="nucleotide sequence ID" value="XM_002177528.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180138.1">
        <property type="nucleotide sequence ID" value="XM_002180102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181930.1">
        <property type="nucleotide sequence ID" value="XM_002181894.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183856.1">
        <property type="nucleotide sequence ID" value="XM_002183820.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr32511"/>
    <dbReference type="GeneID" id="7195535"/>
    <dbReference type="GeneID" id="7197384"/>
    <dbReference type="GeneID" id="7201058"/>
    <dbReference type="GeneID" id="7202701"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32511"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35853"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39905"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47693"/>
    <dbReference type="eggNOG" id="ENOG502SP3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_12_1_1"/>
    <dbReference type="InParanoid" id="B7FRV7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="144293" checksum="541B4073747C5310" modified="2009-02-10" version="1">MRRPRKVTPAVPAPAAATDSPADAASASKEDEEFGGFDSSDGEEPSGTAPPSPASSDDEGDGKKTAKPLARSKNTSDEVSVIEKSVIDAEPHLSKDSDGLDSVPRQDRVERKALMVVLRDVICVPLSVAAAMLNNGIKSSDDFRLLTKEDINDLCMRLKMGSMHTKRILVFAKWMHHAPNSVDVAKEFTASVLRFEMMTRAAASYDNVTTTAAKAEKSATSLLPEPFDGSQKKWLTFRYGFEAWAGASGSTFTACIAHHSDRYSKADPTGPHTSPRDVSDLFALSPVVNITRNATIFYTLMSLTSAGDAWGLVEPHEHTKDGRSAWISLCAFYEGTSQVGLTTEQARATVMESVYTGLSKQFSFTKYVARHISANNALLRNKEGYSDAQKTNFFLKGITDPALLPYKATAEARLDDWNFNRVVNYMRTSATKLSSKDRSDSRNVRQTKTTGRATGNQRGNDNKRRGSSNRPSNKGAEKPSRPHKHVLPPELWEALTPAIRESILSAKRSIAPPGREAKRAKSSDTDNSSSTVESYSQLPSSKKPIRKHTCEDHVQVDSSTPETLLRDAPTDISPHVTTKKVTFGAGVLFGRYANRVSLNRMVRSGSHFDQAPWRKSDFRLNDATLVRIRQNRSRGTKTPTNYGEAVIDTGADTVCVGAGYSVLSYTGRSVSLRGFHDDGETFERIPVVTAATAYDYDDGTTVILIFHEALNLGPTQTTSLINLNQIRHAGHQTDDIPKFLSQGKSLHGIETLDGDYIPFELKGRASLLYSRVPTQHELDNCQHIDLTCDQPWDPNSKDWEENEAKYTRHDRSRRACYTDSVPVDILPDWPPLPVSPGSVVPDFHNRVMNPRDIVREIKYATIGASISSPRVLDVDRDKLRRILGHVPMEVVERTLTATTQLAERTGEMPLHRRYKTKFEQLRYRRLKCTLYSDTFKSSIKSSRGHTHTQGFVCGDSYFIYHYLMKAESAADQGLAEFIHNIGIPAQLHTDNAKVETLSKWKKLTSSHWIKTTVTEPYSPWQNRCEHEFGAARIHTRLVLETTKCPEQLWDYALAYVIFVRNHTARKALAWITPITAMTGDTHDISEILVFEFFEPVQYFDNPDVKFPQNKAKVGRWLGIATNVGQALCYHILTDKGTVITRSTVTPLQNLDSSALQTALATFDATIREIYQPSDFALGNKIKAPAFRRDEAMKVARRSDDPGDGNTRNRHVLYDLNEGDDHIQLDPGLTVDDFFENDSPDQDPTSLIIGTDVLLTSGAVQRQGRVTKRDRDGTPVPNDDPGNFVVEFDDGTEEVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRW8</accession>
    <name>B7FRW8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177569.1">
        <property type="nucleotide sequence ID" value="XM_002177533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRW8"/>
    <dbReference type="PaxDb" id="2850-Phatr43335"/>
    <dbReference type="GeneID" id="7197090"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43335"/>
    <dbReference type="HOGENOM" id="CLU_654649_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRW8"/>
    <dbReference type="OrthoDB" id="49298at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="409" mass="44442" checksum="D5D04A202EE34745" modified="2009-02-10" version="1">MVWCCVAEPLGPEESAHLDILDDKYRGQRLAVGKSGIQPIPSNSAKPDPYDSLVSVTCPAGVRPGQMLQVNSLDGTRAVHALVPEGVRPGQTFIVEFPPQKVFGRVMQAEPVKPPPSFENSLDDWLTSEAQVPVATEQRNEETHGTLQPVPAWVAPSSAAPKRNEKGEAREPPVSPKLPENPVQSFLEKIEDFLAPTPDVVPAPMPKKSMARTKEGKKGTTRERKRPEVLARKDAVESRRQPSPPQSEAQQKLLLVHIPPGLTAGSFMQVEIPGEHRALMITVPPNTTSFHVAYTPLQAPPMTSAVSRTSATSHTPVTPQPVPANQKLLLVRVPSGTSAGTLMHVSVPDEPGRILAAQVPAGNVTEFHVSYEPHPRVDSHDRQAANTLRRSVIATHIVFAKLGLEQFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRZ1</accession>
    <name>B7FRZ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHATRDRAFT_18064</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177887.1">
        <property type="nucleotide sequence ID" value="XM_002177851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRZ1"/>
    <dbReference type="STRING" id="556484.B7FRZ1"/>
    <dbReference type="PaxDb" id="2850-Phatr18064"/>
    <dbReference type="GeneID" id="7197104"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18064"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_5_1"/>
    <dbReference type="InParanoid" id="B7FRZ1"/>
    <dbReference type="OMA" id="ALCKCAE"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC50701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="32699" checksum="ABBF29A941CC076E" modified="2009-02-10" version="1">MFRIGTTLGKIAGNGGAAQWRKCAAMLSNSFSTTLSDLVSTDIDIETGVAVITMNYMPVNSLSLEMFQALSASIKSIEQDERLQALVLQSGNPSIFSAGLDLREMADPDPDRLNAFWTSFQQLYLDLYGSRLASIAAIEGHAPAAGCMLALSCDYRIMSETEDKHAPTIGLNETQFGIVAPPFLAQQLIDTIGRRPAELSLSLGTLYSPDDAMAIGLVDEVVSRDVVRQRAQETASQWARIPSVARVASKMLIRQDAIASLKQNREKDLEQFVSFCLDERTQKNLQAYLVKLTSRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS93</accession>
    <name>B7FS93_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_18128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177625.1">
        <property type="nucleotide sequence ID" value="XM_002177589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS93"/>
    <dbReference type="STRING" id="556484.B7FS93"/>
    <dbReference type="PaxDb" id="2850-Phatr18128"/>
    <dbReference type="GeneID" id="7197160"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18128"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000288_63_14_1"/>
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    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="28556" checksum="F042FC1395D179E9" modified="2009-02-10" version="1">MQHISRQGVHDNVMGVYDVLQDEEYLLMFMPYCSSGDLFSFVQQAGRFPEPMARYWFKQILEGVSHLQRMGVCHRDLSLENILVDKYRTSIIIDLGMCLRVPYDGGNHVTDVSSGTIRRLIKPLVPCGKPNYISPEVLKSHEAFDGFAVDLWASAVILFIMVVGLPPWEYANNDDPRYRMVIGGGLERMLRSWDREISPLVADLLQKMLREDPRHRLSLMEIKDHPWITVDESVDGMPYAPEEEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSF4</accession>
    <name>B7FSF4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GLRXC1</name>
        <name evidence="7" type="ORF">PHATRDRAFT_43497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177974.1">
        <property type="nucleotide sequence ID" value="XM_002177938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSF4"/>
    <dbReference type="FunCoup" id="B7FSF4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSF4"/>
    <dbReference type="PaxDb" id="2850-Phatr9883"/>
    <dbReference type="GeneID" id="7197547"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43497"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1655597_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSF4"/>
    <dbReference type="OMA" id="PFCLATK"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852622" evidence="5">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="160" mass="16861" checksum="6A29B300F2310669" modified="2009-02-10" version="1">MKLVSRSFCTLAWTCGAAQAWSVAPRTVARNRPAWVAARHPHTPTACAFSTTTRLAATPAEFAQTEIDTHAVVVFSKSRCPFCLATKSLLNDLKVDGVIVHELDQMDDGADVQAALATLTGQRTVPNVFVGGQHVGGNDDTQAAAASGKLQDMLAAAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSQ3</accession>
    <name>B7FSQ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_6698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178023.1">
        <property type="nucleotide sequence ID" value="XM_002177987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSQ3"/>
    <dbReference type="STRING" id="556484.B7FSQ3"/>
    <dbReference type="PaxDb" id="2850-Phatr6698"/>
    <dbReference type="GeneID" id="7197458"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6698"/>
    <dbReference type="eggNOG" id="KOG1079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FSQ3"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="106" mass="12398" checksum="62B17DB57E3DC25F" modified="2009-02-10" version="1" fragment="single">GWGCFSKYSLRKGEYIHEYVGELISQEEADRRGQLYDQQNQSSLFNLNSETVIDANRKGNITRFLNHSSNPNCEARTMFVNGDYRIGFFATKDIDAENELFFDYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTE2</accession>
    <name>B7FTE2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_18398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178139.1">
        <property type="nucleotide sequence ID" value="XM_002178103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTE2"/>
    <dbReference type="FunCoup" id="B7FTE2">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTE2"/>
    <dbReference type="PaxDb" id="2850-Phatr18398"/>
    <dbReference type="GeneID" id="7197043"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18398"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_0_1"/>
    <dbReference type="InParanoid" id="B7FTE2"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="305" mass="33167" checksum="B3DC75FA54B43095" modified="2009-02-10" version="1">MAPLRLVLQRASPRVAILATRGMATEKQIFNQIQSTKNLSKITSSMKMVSAAKLKGDENRLARAVPFNGWTSELGGAPKLVEGATFDELPQKVLIVPFTSDKGLCGGVNSYITRAVRNCIKKLQAQGKDADIVLIGDKGRAQLRRFHPEKIVRSATDVVTPGTYALASGLASELIASGAASDYDAVVIIYNSFVNAATYNQMYKVVTPFVTMSETEESLSGYEFDGDKAEAMEDLYEYMLASQVFHSFMDSAASEQSSRMTAMENASKNANEMVDSLTLKYNRARQSRITTELIEIISGASALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTJ4</accession>
    <name>B7FTJ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002178425.1">
        <property type="nucleotide sequence ID" value="XM_002178389.1"/>
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    <dbReference type="AlphaFoldDB" id="B7FTJ4"/>
    <dbReference type="STRING" id="556484.B7FTJ4"/>
    <dbReference type="PaxDb" id="2850-Phatr44273"/>
    <dbReference type="GeneID" id="7197996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44273"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="DUF1499"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801:SF6">
        <property type="entry name" value="SLL1620 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07386">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855425" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="28119" checksum="4489A5EE039B320E" modified="2009-02-10" version="1">MKVARLALLRVAFCLFNGSARVSSLQSKTPSTYCPLSRPALKTSSRRDVFHQTSAAFFSLGVTIPMATTTASAEQVQQEFPTSAGRRGCSTVSDPGKTVVTCTGELLANNKENRLSSIPATQNGVSTSAVKNPSRFSPPWSYLTETSDGAKAWQSLQTAVLQVDSNVKVLNVTDTYLHATVPTAQPPGLSGEAGLDDLEFVLRPEDKVILYRSASRTAIFVYPLTQPVSDGNTNLKRLQKIRNILGWDEMGYAQTGSNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTT3</accession>
    <name>B7FTT3_PHATC</name>
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        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_33765</name>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178203.1">
        <property type="nucleotide sequence ID" value="XM_002178167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTT3"/>
    <dbReference type="PaxDb" id="2850-Phatr33765"/>
    <dbReference type="GeneID" id="7197828"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33765"/>
    <dbReference type="HOGENOM" id="CLU_591192_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTT3"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51211" checksum="8C69778DA95C32C1" modified="2009-02-10" version="1">MDASHDNVDEDPSILDSALLESLFYNEMMLMEESSSTNALRATLFSSLSDDPRHTDAVTDPNTYAEKALLRDFGVEGPTRLDPPVSLWPSTTETPTVDGSSMESSSYVTSGAEHDEEKKAKLVTQFATLASRLGITLPPQVVQSLAGVAAGTKDQHPITSGTPPRNGNALATNGTAAKIQPRSTLPSGNSADALSSHVKPCEQVQFLHSAAEAAVMTVTKKRSFSDADGNAAPAASSQPAKPAYSKRRKKPRLADCEHKLLHLQTENAMLKRHLANVSQKSQAQDAERIQAEEKMRVMLEQNASPEELDAVVSYYKEMYSDYGRRRHQEILFHLEQLQRLANPTNFTKMGLWTLGQQSKGPDPIAGILQKELDIQPQQGRKIIEQRQKIRNVCSNLKECLFLLGKLKTLCEQKTSIFHDRMTKCREILTPRQVVMLLVWINDHSQVLQSVCPGWGSELRSKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTU5</accession>
    <name>B7FTU5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_33776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178480.1">
        <property type="nucleotide sequence ID" value="XM_002178444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTU5"/>
    <dbReference type="PaxDb" id="2850-Phatr33776"/>
    <dbReference type="GeneID" id="7198042"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33776"/>
    <dbReference type="HOGENOM" id="CLU_1597661_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTU5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="182" mass="19757" checksum="13A37CDA39D1BDB6" modified="2009-02-10" version="1">MDPQNNDLSQSLTGSMGGGADDNASQTSQRSGASLLQRIQMQRNREAQEQSSSSSNTYNLHARPAQQIQVPQYNPGPSQENFAGGGPVSEPGNNLFSSAWNNISTSVESGMASLQQERTGGMEASDALLAPSSQNEHGDEEYSMSKYFLTFVRDVNGLFYSLPMWARVVVVIMLLYVAVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU25</accession>
    <name>B7FU25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178528.1">
        <property type="nucleotide sequence ID" value="XM_002178492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU25"/>
    <dbReference type="STRING" id="556484.B7FU25"/>
    <dbReference type="PaxDb" id="2850-Phatr44427"/>
    <dbReference type="GeneID" id="7197669"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44427"/>
    <dbReference type="eggNOG" id="ENOG502RYRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052111_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU25"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF101">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855010" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="311" mass="34673" checksum="FC10B8302C25ADED" modified="2009-02-10" version="1" fragment="single">MPSALVTAFSLFFLCNLGCTPQAMTSSLRLRVVSYNLLSSHLATTTQYPTLNPEHLDAKNRLPLVLNKLEKEIQSNQNVILCLQEVSYDWAGSLHTFLANRGYHLVTGSYGKKFNGYMGVCLAWPQDSFVVEDVDISRIADKREGGWPVNEEPPLLQKVWSKLQTALDKPLRKLGLVSGEDIDHWDMSERRFNVLVSATLKEKASGQSFCIGTYHMPCAFYAPMVMTIHTDLAARHVQRLAESHGSIPYILAGDFNFKPSDPCYRLLTTGEIDSTDPYHPSPKGGVEWKPSSINMASAYAVSDHGEPDFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUP4</accession>
    <name>B7FUP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178630.1">
        <property type="nucleotide sequence ID" value="XM_002178594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUP4"/>
    <dbReference type="STRING" id="556484.B7FUP4"/>
    <dbReference type="PaxDb" id="2850-Phatr34085"/>
    <dbReference type="GeneID" id="7198112"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34085"/>
    <dbReference type="HOGENOM" id="CLU_532644_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUP4"/>
    <dbReference type="OrthoDB" id="41245at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="2">
        <location>
            <begin position="255"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="512" mass="57125" checksum="112FC0EB3FA24E30" modified="2009-02-10" version="1">MTIENEYESDSEFSEDASENEEDVKMRALLAEWDDKDMSKDDLYVDSDEDEEEDDSAIAKRKALLKNTQATDDSDSDQCEAEAFVDESSDLADARAAEDSEVEEEVVEEIEEVEEDEEEDEEDEEDEEEEEEEEEEEVANDFGGKDGDGSECEEEGQESVVDDTKSVDTISIGDDNENAIVDQLKKKPKKKREKKPRKKLTESAEEDTEEDAAMKELLKTWDADMGVKDEDDGDDDSDDDSEASEREVFLEENVIDHIVLAASDLEDAISQFERKTGMKPVIAGTIKGLGIKCARVSFTDATYIEIIAPDPKGPGPIGELIKNKKIDDLTPFHFAIRTSRAEALKEEVTKWGYTPDHITMFGAKPDGTPRKWEMLYLYGHKIGGICPFFINWANSDHPCATLPVVGKLKKVYVRAPENDPMHQLLAHVGVKGLEIEVGKPKFSCKFASPEGSVKFSSDKCVGFKFPGFEADVGSIPGDNGEQDAEVVFEDPKLPELLPVEDIEYDDIPEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUQ7</accession>
    <name>B7FUQ7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002178604.1"/>
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    <dbReference type="GeneID" id="7197630"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44627"/>
    <dbReference type="eggNOG" id="KOG1489">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="B7FUQ7"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ribosome biogenesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="MMR_HSR1"/>
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    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
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    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="OBG"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="124"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="308"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC50305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="652" mass="70020" checksum="C4A8629C96C88B20" modified="2009-02-10" version="1">MLVTGTPACSGKIEPFTIQSDISRASGSAVGDVSVNKRMGVAPILTIQSSSRNSFGRWGFGYDLQIRPIRCEKDGDENPTYYSPNRPLQDFKSYAVTSADGNAISDSDQSLDSLEALSSSVNEYSFFDEAILYVRGGSGGQGSSTYKKAAGGQNGQPDGGNGGQGGNVILQVDVSLNTLAGLTQAWRPNSFGGSGAAAAPQSTATLRPKSFRAENGSDGDRQFKNGRYGKDVYIRVPPGTVVQEEISPGDYRELGSLTEVTDELVVAQGGQGGEGTGVQGRNRGVRRPRIPATGGDRKVLKLTLKIVADVALVGVPNAGKSTFLAAVTRAKPKIANYPFTTVIPNLGVWIPGGALEEAQSSQPDKGAGSEGLVLCDVPGLIAGAAQGVGLGHAFLRHVERCHVILHLIDATSNDPAADYEMLNREIVKYGTGQLAQMPQVVVINKIDAFEGAKQEWEEGLEVKWARNDLERKMKESMPHSRLMWMSAREREGVDDLMSRLASFVKKVKAGVPVKEPFQSLSAQMSVTHVPGKHVPHMQNILYQPTLMACWSSRHIHFYFTGHHQSVSIPSGMFLDRQLVGASNGNHARAPGREKPSRTWIRLCIEVLASVNAWSTVTIQRNLKSVGLEGCRSLETASFLSPECWGQAPRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVJ3</accession>
    <name>B7FVJ3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_11183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178941.1">
        <property type="nucleotide sequence ID" value="XM_002178905.1"/>
    </dbReference>
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    <dbReference type="STRING" id="556484.B7FVJ3"/>
    <dbReference type="PaxDb" id="2850-Phatr11183"/>
    <dbReference type="GeneID" id="7199879"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11183"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539147_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVJ3"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC49639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="266" mass="31218" checksum="DEC85F5182E10AD6" modified="2009-02-10" version="1" fragment="single">MVIGTVILSLRLVYLHLTHWYMPEVQKYVVRILWMVPIYAVQSYLSLRYHELRIYIGSIRDFYEAYVIASFVYYLIELLGGEESLIHILQQKTGTRLGKHSFPFSLILQPWEMGIEFMLQCKHGVLQYVVFKTLSTVTTFACESAGIYGEGKFDWRCAYPYLCFFQNISVMYALYCLVMFYHAINEELRHPVNWHPLGKFLSVKSVVFFTWWQGVLIFYLRAHGIIEHMGSWSSEDVANGLIDYCVIVETIGFAIAHSYTFSYKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVP4</accession>
    <name>B7FVP4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178741.1">
        <property type="nucleotide sequence ID" value="XM_002178705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVP4"/>
    <dbReference type="PaxDb" id="2850-Phatr44800"/>
    <dbReference type="GeneID" id="7199755"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44800"/>
    <dbReference type="HOGENOM" id="CLU_722542_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVP4"/>
    <dbReference type="OrthoDB" id="47279at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="383" mass="42190" checksum="A06B6AA191316CFB" modified="2009-02-10" version="1">MSTDHDEKIVEDIPQMRSVAMMSPVPMVPLARSIATPKAQLISSARFVEKKEIISPSPTGWELAVTDPLPAIYMLERTHTYVSNAGAKEVANRIANSLRLQSIAATFSTKEALATAETSNQVVFTIRLWSHKKQVLVELQRVSGCCFFYQQTVKALFRAAKGEPERRLSYNYSIPDCVPQESPEETKQCVQEGIDCASALLKKEGRFDSHALAMESLVHITNATKCRTFAAHCILCGDFLSTLICLVEASRMERPGTAMQGLSSMEEEHFRVMHRHALAVLANCLSALDDSGELAHVLKQQPELSSTTFLLALLDDVENATDRPHDACQATRCLCALVQTCSDTKSRIVGELGGLPALEAAHSQGICRNAYLETECQKLKLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW91</accession>
    <name>B7FW91_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179118.1">
        <property type="nucleotide sequence ID" value="XM_002179082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW91"/>
    <dbReference type="PaxDb" id="2850-Phatr45037"/>
    <dbReference type="GeneID" id="7200061"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45037"/>
    <dbReference type="HOGENOM" id="CLU_361509_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW91"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="774" mass="84726" checksum="93E0DD7B7F8C624E" modified="2009-02-10" version="1">MDTYRRDTFAVIIVSFSWILCAFCWNLPSVTATQSTDERWVHRRIQDDHDSSCPGDSIWHCDNPDLVRSDDPTVGCDKETCEWYIDWLDPDNKPLVCQGIVILLSSIAFLPNELEPCLLWELEHGHSGLTTARALEAFTDDFLTPFASPHTTTTPTALASTISPLPTPFESSASSLEPATEDPITSNSVEFDTVLVSYFVLPGALRRQRRLVAQFDLVALQETTSVHIQRELDALYGQDGFVEQVDVLLVLADSTQLDDGAIVETYAINGVVTVADVDLIQANSVSRLIRKSFDDEPLQRYLGLLKASDDPVLQQTYQLYVGLPSDLNLEGANPTSGNDQDASNESEKDKLLDFEWSALWIAVFAGAGFGIILLSAILIYLCCCRNTTSRLQHSKSGGTVPSSRNDVDPTDPTGYDNSSFTDRGVPQDTSDDCAGSETTSVYSYVDSGTVIDSIVDDQNYSIAPSYMHGIHTSLKDNQRFKNAYEDDDDEDIETVQSRHGMWSVIDGIEDGNMIDANIVNENTPSVSSTSSPSRMVVTTERSKKANGEFLIFSDEDEDDLSLVSEHYKLQIAQTRSVCSAKSSLGLGGESKIGESWPDDEEESEMSGRRLPFTNSDSPSQKSLVSSPGSKLTLSAASVSKEQRSWKTTLTPESHVSTAASSSDDDSSIFLGADSSLANRLTNDKSILQLRPEHSVRSVRDGPIGHRTQGLSNGTILSPKEKAQLGWNASRSLPDDGNSDSDSDIESVLIPENYKMNPEPIAGPNDYPLESMASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWC3</accession>
    <name>B7FWC3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179356.1">
        <property type="nucleotide sequence ID" value="XM_002179320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWC3"/>
    <dbReference type="PaxDb" id="2850-Phatr45062"/>
    <dbReference type="GeneID" id="7200283"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45062"/>
    <dbReference type="HOGENOM" id="CLU_396128_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWC3"/>
    <dbReference type="OrthoDB" id="49218at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46517" checksum="4C2B2F24E12F9D76" modified="2009-02-10" version="1">MFAVASLNIDAQPLQGNVDQRVILGASTRAEFGSSQTSGQSYSSLRSNTNNARHHFGGSNNSSNEPRYLDLTDVLLCLSLALTWTVWMLTGFVRTDLWKFHDQSVVVAGNVRQVQIAADSLGTGIPCYSAIIDYMIHLERRAETDDMVARWTHTRRNCGADDSVLEYNHSPASPGNANGNHAKGTVTRFQIRKQFQTTVPLEEGFANVELLVLPHEPTVSMLKEDWKRELLEQQQDVNDGAVCCRPVLCRRLSMIFAGVLVLVSIGGAVLVVDHMDPVDKGLGWGVFCIGTALLLPSALGLHRLGTAVSQMLSDPSKTGRVLQGAEELSATTAAQWDCQEFDVLDARACDDEGEILSAIQHQQQEGFGGSQLPLPHGRRRPLYAHHGGAGVPDTAGCYFIRFPLHRHQNRTRSHDVSISDGLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWK5</accession>
    <name>B7FWK5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179398.1">
        <property type="nucleotide sequence ID" value="XM_002179362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWK5"/>
    <dbReference type="PaxDb" id="2850-Phatr34752"/>
    <dbReference type="GeneID" id="7200323"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34752"/>
    <dbReference type="eggNOG" id="ENOG502RYJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091173_0_1_1"/>
    <dbReference type="InParanoid" id="B7FWK5"/>
    <dbReference type="OMA" id="ESSSHGW"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852753" evidence="1">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="198" mass="22060" checksum="921AEADC798DA974" modified="2009-02-10" version="1">MKATHLVPSLLLIAGLSGQQHLVTAGLFGPSQPRCDAPCVAGDESIMSPKEHGTSHVPVQSNLRWQCDRKVADRICNYNRHYAEYSGYWETTTFLSDPSTQDASEEKPVTFYDSNTGNPLFTAPVGRSWREFLIESRYHGWPSFRDAEVHWETVRMLPNGETVSIDGTHLGHNLPDRSGPRYCINLVSIAGNPSTDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWN5</accession>
    <name>B7FWN5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179194.1">
        <property type="nucleotide sequence ID" value="XM_002179158.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr45161"/>
    <dbReference type="GeneID" id="7200083"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45161"/>
    <dbReference type="HOGENOM" id="CLU_262430_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWN5"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1289" mass="140826" checksum="6CC3478CD7EF0F82" modified="2009-02-10" version="1">MAALSHSVLVEGSILSGDQLRDYAYSHGVCPICAAQKTHRKAGSILNKIWEPITDTKNGEYAVYKGYCLQPTCYTLAEAQSQLGERTSPKKKKKRRSRKSLGSVSTSIHTTKPISKGIVVSKSNLSAVTRSTHNSSKSTLPRSQLILQPSPTLTTPKSTTSLNIVTRSSFARLNVLLPSAPGKEMNQKTISKTQWDQHLYRPILATSKAQKTNSIESQTSPSPATLQLHPLEDPHTLYDPSIILQVLEQHAGDPQVAACSLQSLRKTLVALQYTDFYSQNDSWINILCAKIKYHSHDVNVASQGVLSLLTVAAVSSKYAQSIISNKGIGLILAIDRSHEGCTHGCIGMSDRCCAALEVLLGACKRVSQGDLKCLVERLVFHALGRDIACSDYALRALFHVAQKTVRGRNELDCTIYQLVHSVDVVNLLWAKLDGDLVSALIAESALYLLWKLSVNKNSEGAQPLRVTRESAGSLLRLVVKYDDVFLHDAALCLVSCITLTAETAHRPEFVETVVSAVCHVLRRHPNQEIIQVKGLYVLTKTFGGRAFSAAIQEDIEISAIEAARQFPTSAALYAVACRIIRENFERGNGKENGISNSVAPAFLAGAFQKCVFDFPHDEVDSIAAKDALISALIKVSGNVTACRELARSDLLCNVDRAMNKESDALYLASFHRIGINILTLLIKDVQHVQDSSDTKEGVSFSRHSCRLLEMVEISTIVAPECCILLAGIYSAVPFRGSFGQHSKLYTSLGSLTIVSHTQDEYNAILLSMRAYKENTEVQKVCCLALSNFIAPICHLKRAPESCDTIGHMTSGTLAMLADSVSFHKDNADVLCSCYSLFWTLIFVSSHADLQRWTPKLLASVFEASKRHKDSIEIKTVMVSVFRALLANDAGFSSLSSQQGVSALFDSLTNADDSIVIQAAQTLACVVGHDYETGSLLNTIKGVVSSILTCMTMHAWSVEVQLSLSSVLEALVARQESNICREVVHCGGLEAISTILRAHASEHSVIQYACQVLVGVLSEVDDNILWSHRLSLSQAIVIAFEAGSESPTAICLLEAILCLCDTADYFRELVAVCFPFVLRCMASNLRNVTLLKNGYRAIRVLTPHVARRVSLIDRAGLNVVVNGLLVHPESKELLLEGLEAIKILALDSGTREGLDRAQVQETIVCLMEINAQKPDILAQAFAALNNVVIIDAAKSQVSPLREGVIDMIILAMFRYPLDAKTQENSCMLLKSYTYSPNLFDLVSDKKDVLIPILVSAAENFPEVCGKRACSILKRSRGCNVPQKEFTNSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWR9</accession>
    <name>B7FWR9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179428.1">
        <property type="nucleotide sequence ID" value="XM_002179392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWR9"/>
    <dbReference type="STRING" id="556484.B7FWR9"/>
    <dbReference type="PaxDb" id="2850-Phatr45185"/>
    <dbReference type="GeneID" id="7200357"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45185"/>
    <dbReference type="eggNOG" id="ENOG502S1NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_2_1"/>
    <dbReference type="InParanoid" id="B7FWR9"/>
    <dbReference type="OMA" id="MANVAHF"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF11">
        <property type="entry name" value="OS06G0360300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="33608" checksum="39CE2E7A415A1CD8" modified="2009-02-10" version="1">MFYRTTRSREKSKDLNRSKKMQYHLFNAILGLVAAFLIGRLPFVSTEKLHGASECDSSAVTPITVLVVGATGATGKHVVQQLLEMGHNVRVVVRSRRRMLDMVDFQPSDHFVVTEASILELGDEDLKQEVEGVDAVVSCLGHNMDFNGIFGQPRSLVSLATSKLTETMKATAKAGRPKKFILMNSDGVAHPAGTDDTRPVLERILLGVLRLLIPPVKDNEKAAKVVHEFQSNGTIEWVVIRPTDLIDGQPTEYVLYDKPVGSLFGGGVTTRATVAKCIVDLILDQVLWEKFKFQMPVLHDSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXK8</accession>
    <name>B7FXK8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179785.1">
        <property type="nucleotide sequence ID" value="XM_002179749.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr45406"/>
    <dbReference type="GeneID" id="7200530"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45406"/>
    <dbReference type="eggNOG" id="ENOG502R32Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242374_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXK8"/>
    <dbReference type="OrthoDB" id="49645at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051888">
        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1654" mass="181404" checksum="C37124EE2BB6EF51" modified="2009-02-10" version="1">MRMATDAPTAAPSRTEMSSAPSEADVETLLSQRLLQGFLLLEQPCPVCATPLVRQEDPLPSDDNASAVSAIEPIQGVPFCVCCRAHVVTQESEIALLSGDSVDENESGVGHKPRPVKGSILVAVPSHSVTPPVASQGGQRDQGDDFEEDFLEILTENDSTIATVEDVKETKPQSIERPHVAPEPHTKPSPPTGRSVDSSTQATAKVSQVVLDDLNEDSIELVRQPTMASVQGEIDRDDEIVCTTDDQDKEILEIEVITKVHSMLDAMEELTVDGSYMAGSVYNSEDEHHGDENGEETEFIVGLQKEKEMSAGVTTEDAKSSNTSDKSGKPSRESLSPSARIAQRNLLDSRHLVSEEDRPYWPDYAERRQIATKILADKMMEGLELREEQCQRCSMPIMNEGQSDSSGFCTVCPVLDENMATKRLEDETQVELARRRVVQEEEKQRLAQKKLELEKSIDIQRKLRAKKHSKLDQVKSRAVSMALVVAASTTSVEVTTANNKSSKVSPSSQSPSSVETPALCPKQEKDEASKAAMDSVDAPQEERQGQNSKAADNIEKDEESTLQQAKTTGAQSISTNPTAVSTLVQANTMSDIHTPKLMELNVKTVEVPDVSMQRSVVTRDLQPADCVEATLGPLKFLDSDHFSVIPPLPLQKMKVEKEAAHLLREVGKAEEAKRESLRVLDEATKAHTEKKNRAVELTEEIAREQTLVLKETERLQQLEAQQLEQNRTRTSRSASISNKDNEELKLQAEIEKAEKARDAAEFERQRLADEKQALEESNLLSELEKDANKKQREAEEAMGRAKAAIEKVVAVQRKIFAKTIAAGEVSVVAEAEKISRADTEDYHERNIKPSASEVCRERWETLRCESKAVRTRRLLSGWTTLPELCRGQECQSSPLITNSEEKECVVCGGCGSGRDGAYAQMINGDDESEDGCSQIILLQETTPSVLSFPTDFAGTFSVEEHTTAILSPTPRKCVEEIHKDFERKRNAVSKEIGKKMLQGWILLDLSCPNCVMPLMTDGDGEREICILCGDVGQFGNYDDSTKATSVATTVDKTVPYAQLNASDKIEVMSSRDCSTVGLNTLSTKENRKISCVLSTHTSREAAEIPRAAVESAKKNAKGAHSVESQVPCKNQQSTGDEVNSLSITANSGPNYVKKTGNAAKTRLPAVVEEDRTSLETSLCPSRSRIGNVESKSAPGKGKLQTHRKLDPSPRSSFNQKKPSLNACKEPPSTIKSPTVRSFSDSFEMSKRIQGSHQRRHRKDPEVLVTSTSAETKVVEPASSMDLSLGGDLASSTIASPSSIRNKAGRTQSDTKRSAANSISHILSPKNRHRSETLRGDPPAIQGCSLGRRNAKEVEGRRADELPTEHSKTTHDTPTSEGDSQSKVEWTRKLAESNDENREIAAEGTDDHPITDEGRFETNECIRGSEDNNGVQQIPIDFNRGIEQPIGDLITVAKARQPCYTDMSVRTPMDDQSSKGIPLHALHLPSPGMTAASAPYLSPTSYRESAPASVAPTLGSFRPRITPETSRRDRKRTLLSGLRPAFPYQSGILHSKAKPPQSDFVVYGGPLETPELLVTGTNASVTSEAIDTLLARIEETKAQLEEHPDGDNLENQNRLSQLLANLASAAEAMQRFDELEAIDRFDEMTDTWCRSAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM7</accession>
    <name>B7FXM7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179795.1">
        <property type="nucleotide sequence ID" value="XM_002179759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM7"/>
    <dbReference type="PaxDb" id="2850-Phatr35126"/>
    <dbReference type="GeneID" id="7200510"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35126"/>
    <dbReference type="HOGENOM" id="CLU_487040_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXM7"/>
    <dbReference type="OrthoDB" id="48655at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="40712" checksum="A7571D909F998DF4" modified="2009-02-10" version="1">MVIVDIDTALEKFPQALACQTFPDILGEETPPRAYSCADQVQSTGSNSDNAEYLLDDLLDSFDDEDDGSSAGSSVDKEEKGVEQYYTKFVKNSKESSKEFPIAKEILSRGKASEVTLAMIHKRMAIEASKSVVFKKHAHSDETSKTDSDLTIEKYAIKQYIAFPSIRGDEESTISEITDTDDDSEFSEESSEGTGDLLEKAQDRVIQQRLYEEVKELKHVLETKNEEIESLAAHLRRATASKCDLVIAHTELENYHAQNIKVKDKNVKQLTKFSYSLLELRAEVEKEFMNEISHLSNEIKEMEAQHRSELDDWERMHRNEMLEKDFQIAQLTQELHVMRNEGLKSPKKALSKIFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY12</accession>
    <name>B7FY12_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Diatom response regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DRR1</name>
        <name evidence="10" type="ORF">PHATRDRAFT_45539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179854.1">
        <property type="nucleotide sequence ID" value="XM_002179818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY12"/>
    <dbReference type="SMR" id="B7FY12"/>
    <dbReference type="STRING" id="556484.B7FY12"/>
    <dbReference type="PaxDb" id="2850-Phatr12051"/>
    <dbReference type="GeneID" id="7200614"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45539"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_4_1"/>
    <dbReference type="InParanoid" id="B7FY12"/>
    <dbReference type="OrthoDB" id="204659at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="REGULATOR OF RPOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111:SF1">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ORR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="C-terminal effector domain of the bipartite response regulators"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855158" evidence="7">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="89"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="8">
        <location>
            <begin position="248"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="319" mass="36299" checksum="DC5F97AFE2F84B49" modified="2009-02-10" version="1">MIAFYHRYRTPLRRLRLWCVCLTYLVSLHSTNALIAKSCGSRQITGTWGYAHWARYGALRVKTFDPADNETEHDRRLQDHTFQARNRCWIVLVDDEESIRASVGQFLFDQGYQVTACADADAVLQVCAEPQRPGQLPRLPDAIVSDVRMPGKDGIELLGIIRNSQRLERVPVILLTAKAMTQDRVLGYRAGADVYLPKPFNPDELLSILDNTIQRKQQMTGTNGSLLDLKEEMSNIKELMKQNGKNVVKKTTVYLTPTERKVLGYLSQGYTNAEIADARGVNVQGVIRMIQKMYSETGTRNRTELVRWAMQTGYVSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY25</accession>
    <name>B7FY25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179665.1">
        <property type="nucleotide sequence ID" value="XM_002179629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY25"/>
    <dbReference type="STRING" id="556484.B7FY25"/>
    <dbReference type="PaxDb" id="2850-Phatr45551"/>
    <dbReference type="GeneID" id="7200620"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45551"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509505_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY25"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="6">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="535" mass="58775" checksum="AF048F5E1DEF99F3" modified="2009-02-10" version="1">MFAAMNGRRLSNGTDSTRRLLHREDCGGSSGVRSSRPVPNSSRPQTQRVRFPDEDRESVDGTLDSLFGLITAALATACSAGLFTMLPFSLAAYRRLASQLGASSILDALALLLPNTRICLSGDSDIPSPVGTSILVSNHLMDGDWWALLMLGRCVGLRGSIKFFLRNEYFNLKLHNSDSATSRSNSTTIATSKAVGTAVHIRNENAQASSSLPRVSHLREGSTSHGIAIMANLLHQFLEFPLLSGDDHTADREQLVRLLRSFAHDNASAPVHLLFFPEGWSLHNGADRTAILAKSNEFAQREGRPQLKHLLLPRARGFNASLECLRESSPVVYDVTMAYSGYNGSLPPSIELTFPALWKLLRGFPREIHIRIKRYSMEEVTQDSSWLDQKWAEKDRLLSHFARHQTFPADNRGYCRHRVFDTRTHAFESSIIALGRLLLLPLAVPLFVLVSIPIFWALMWLWLAHWAYRQLFGRVEQSSSNGGSSGSVGSAGAGTTPGTSSASGTPFFPATPFASPTVTSWRDMFSKSASSSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYP3</accession>
    <name>B7FYP3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180008.1">
        <property type="nucleotide sequence ID" value="XM_002179972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYP3"/>
    <dbReference type="PaxDb" id="2850-Phatr45792"/>
    <dbReference type="GeneID" id="7200925"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45792"/>
    <dbReference type="HOGENOM" id="CLU_267016_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYP3"/>
    <dbReference type="OrthoDB" id="42277at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137397" checksum="719CAEC0B24FB442" modified="2009-02-10" version="1">MPRRGVPDEAVRVSRTAEDPALRELERRLNEDVDEDFFEEPRRFNTLHRVIDVLGLQMIDDATTLGGDETAPLHANPAYRNLQTQQDVVEGGVCVPAQPNGNQPHATSHFSRTFPVRLIAIEHMAVIHCADLNGSVIQVGQVARHFTDAVGKVRTLRHQVREVQNALGANAPRSSNPNEATLSTPLRTTPRSHNNAAATSLRELWLKKLECEATLALLDRLDVIRAAPAKFDRLVQGNPMVPCRIGAAVLILSQALTVMFADDVAQVQALHKIMEQLLLRKQKAEEIVWDTLADVLYLRTANGTLPQKVTPQHQNAVEHKNVSGGHSVSSESRRSGARSRVAFRIPAPATPLMHATRSRDGMVNPFVSANLHYTLDHNDDLDHDSVVSDASHASLFSIEDWDDDNSLAGGAGQPHHARTASSSGSVGSTEAGGATKTHASPRNTRRTMIPIPMMEVELDLEADERRCLEDFALSMLGRSRQQPTATTPRDRHPHGVRTPRYNDPVLALRILADCLTHLQRLDDLERVLHESLPKEIRAIIQREQIHTFARLEKSRPKSIRETKADTMQEFRRHLAALLSAFGNVMVRLSHLAQIVRFRISADRELAQKMESPSSFLRSVLSTAYEIMQREIKEFLKACLVPSDQSHNGVDAAMGKRSSGYERGLFSLGIVESESANKDLASTQKQSATRSNVMEMTASKFVASVLFSKTKSEPNVRHALTFRRSIARWTMENEAMKNELAVLTGEDPSSPSFRAAGYEMAITYLDNILQKDLLPTMQEQAVNGTVRGLERRDAFDPILDRGLYARPNSSEPQDVDMCAACQVLYDETAPLFVALHRLPRGGEMYLPTVAVLEHVVLTFRSRIKKQIAELCEKKTALQVLLMDGTDGVSAASVLERRRPFALLQRAYAHGETLEIAPAVDEGKKQSGILPLSPPVKDSAPRQSIGDLKTDTPVEDLADDVEGETKVFDLELSFLGQYLDFAGDDKLKEVICSDEELMKSATLAHGLLKLATLLDNRLMVRGTSGYQKPLTSTRALREAIKTIRDSGFKLAKFCRLDMILQTTSRLSKVCTSSTLVAHDAVRIPSSVNDLGEYMTGASDNLREACGNAVTAYILSSLEQYIPHCLMETVRVLAKGKGIITRAPLTMNGIEALDRSGSVLYRDLKGATSFDNSFWDVELAAYSFEQSASMMAMMELEMEELEAFYASNKDDFQDEDFELMFGMTGPRRKGNVGRFHMLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ80</accession>
    <name>B7FZ80_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_20318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180104.1">
        <property type="nucleotide sequence ID" value="XM_002180068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ80"/>
    <dbReference type="STRING" id="556484.B7FZ80"/>
    <dbReference type="PaxDb" id="2850-Phatr20318"/>
    <dbReference type="GeneID" id="7201016"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20318"/>
    <dbReference type="eggNOG" id="KOG2017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_0_1"/>
    <dbReference type="InParanoid" id="B7FZ80"/>
    <dbReference type="OMA" id="FPTKYLI"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852790" description="Rhodanese domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="460" mass="50112" checksum="743B16486E414364" modified="2009-02-10" version="1">MMTSFAKLFSIFLALNSISTYRVARGFAPMRIEALSYHQRTPSSTRTASITEDLSHEEISRYSRHLVLSDVGVRGQKALKNASVLVIGAGGLGAPCLMYLAAAGIGHIGIVDGDVVDESNLQRQIIHGTSTVGLSKCESAARRIQDINPHVNVRQYEEEFTSETALRILGDGFSDKRRYDVVIDGSDNFPTKYLINDACTITNTPWVYSAILAFEGQMSVFNLDNGPDYRDLLPTPPPPGDVPSCAEGGVLGVLPGTMGCLQATEVIKIVLGRTEGCMSGRVLIFDAMRMKFSEVGLKRETDRENITALIDYKGFCGGPQAKSEQAKGLMNANGRTMDEAESGIEASSTGDSPSFHNIDPQKALAKLSSGWSPWVVDVRLQTENDIVALPFTDRVVPHRTIRVKDIPEDGDVLVYCKAGIRGKKACSSLVEQGVDPGRLFNLDGGIMKWQKELDPSMPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZB6</accession>
    <name>B7FZB6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phospholipase D</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_12431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family. C2-PLD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180318.1">
        <property type="nucleotide sequence ID" value="XM_002180282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZB6"/>
    <dbReference type="STRING" id="556484.B7FZB6"/>
    <dbReference type="PaxDb" id="2850-Phatr12431"/>
    <dbReference type="GeneID" id="7201033"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12431"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZB6"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09139">
        <property type="entry name" value="PLDc_pPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09142">
        <property type="entry name" value="PLDc_pPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024632">
        <property type="entry name" value="PLipase_D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF60">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12357">
        <property type="entry name" value="PLD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC48509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="801" mass="91199" checksum="B3DE628C156A4966" modified="2009-02-10" version="1" fragment="single">VLLHGYLHVQIVRAKELRDFDCMIGCRKASTALRCCDNVSDPYVTVHAGDHRLIKTSVMTNRLNPHWKESFVVPISHHVEALEFRVKDSDFNGAMNLLGKTFLSISDILKLNKEGKPRRTGIHKVVHLDGKPRHGSFEYFVEYVPAEMMKDGVAVPGTYFKPKQGNKVKLYINADDRGSEKGTPEVTYGANNDQVWKPNRLWKDIYESICQANELIYIAGWAVDYEQSFLRGEEREQALDSDKYSPYIGDLLKAKAEEGVTVNVLVWDDQTSNGFNGEGMMATKDEELRQFFKGTKVNLHLAPMLGGESNPYFEQIRNSMCFTHHQKIVICDEKSELVGYFFAVGGIDLTYGRFDNSEYSLFRTLASDHKGDFHNGCHILKSGDTLGPRQPWHDIHLCVRGPAAQDLLQNFEERWRRQAISDADQLVDRAKKEIVAKSLDQDHGGVWSTQLFRSIDARTASFDPEFVSDSADGFVFPRTLDQKKGRAIDHSAHDAMVYHIRRAHHTVYIESQYFLSSSHIWSEDTATKCYNLIAAELTWKICQKIEARERFAAYIVIPMWPEGVPESGSVQEILRWQRLTIESMYRRVCKAIQRQKDLARQSGSQFDMEATDYLNFYCLANRETEDGSEAQGVPRPQSIEETLSKSRRHLIYVHSKLMIVDDAVALIGSANINQRSLDGTRDSEIVQGVWQPDHLATNKSIAVGDIHGFRLHCWSHLTGKMEDIFRDPSNLDCVRRLNTIAKENWKIFSQEQVAEMNSYLVSYPIRVDADGKLSGIEGDVFPDTKAQILGSKSFLPEYLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZJ4</accession>
    <name>B7FZJ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_50914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179957.1">
        <property type="nucleotide sequence ID" value="XM_002179921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZJ4"/>
    <dbReference type="SMR" id="B7FZJ4"/>
    <dbReference type="STRING" id="556484.B7FZJ4"/>
    <dbReference type="PaxDb" id="2850-Phatr50914"/>
    <dbReference type="GeneID" id="7200874"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50914"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_3_1"/>
    <dbReference type="InParanoid" id="B7FZJ4"/>
    <dbReference type="OMA" id="PEKRCKF"/>
    <dbReference type="OrthoDB" id="90288at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="388" mass="43010" checksum="C083F46753993651" modified="2009-02-10" version="1">MSNLQILSKFTVGGQELQNRVVLAPLTRARCTPTEDPLDTVSRTPNDLMATYYEQRASAGLIITEATAVSEEGYGWLNSPELRTEAQMEAWKKIVDKVHAKGSKIYVQFWNMGRQAHSSFHVESQRVVSASDIPMADSFKVKSSTFEDVPPETPVPLTVDEIQSVVADFVHGAKLARQAGFDGIEIHSANGYLIDQFLQSKTNKRADQYGGSMENRFRFLKEIVQGIVDSGAYPSNRIGFRISPNGVFGDMGSEDNAQMFTFVAAEMSKLKVAYLHLMDGLGFGYHGLCPAVTAADIRKVFDGPIICNVGLTKEIAEGMIRSGAADLACFGRLYISNPDLVERFANDWPLEPEAAYQHWWQHVGAKGYTDWPTYKPSEEDSDDAQNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZV6</accession>
    <name>B7FZV6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180372.1">
        <property type="nucleotide sequence ID" value="XM_002180336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZV6"/>
    <dbReference type="STRING" id="556484.B7FZV6"/>
    <dbReference type="PaxDb" id="2850-Phatr12863"/>
    <dbReference type="GeneID" id="7201530"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12863"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066239_1_0_1"/>
    <dbReference type="InParanoid" id="B7FZV6"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="212" mass="24481" checksum="E6D0C4962E4E6B9F" modified="2009-02-10" version="1" fragment="single">QYLSRLTDVQQMDIQSALDQMKSLLSTRPQLVYKTAYYRKQTKNHWARDDPAFVALQAVFLLIACIAYAVSFRISVTDTISFLLYNALWNWLGMGFILASLCREIANRHLTLHQSNSHVRQQVELLYAFDIHCNAFFPVFVVLYGIQFFLLPFVLAEGLFALLLANTLYAAALSWYWYITHLGYRTLPFLSNTEVFLFPIAAIVLLYTVMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G066</accession>
    <name>B7G066_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180624.1">
        <property type="nucleotide sequence ID" value="XM_002180588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G066"/>
    <dbReference type="PaxDb" id="2850-Phatr46135"/>
    <dbReference type="GeneID" id="7201234"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46135"/>
    <dbReference type="eggNOG" id="ENOG502SY5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390564_0_0_1"/>
    <dbReference type="InParanoid" id="B7G066"/>
    <dbReference type="OMA" id="IEVCASE"/>
    <dbReference type="OrthoDB" id="49573at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="707" mass="76379" checksum="CA67E078FA974DA8" modified="2009-02-10" version="1">MVVTIPETGGSTSASTTIPPLSKGLITPTMEEAQRNFANFMHPYSPDSARLDDSVTTLWDNFLFLSATLFLHSMATMLWMVRLVITSPLVCWMVTRTITLQHWLGDTTLGRHALSWRWLERHKGHLPSWPPPTLVCLALLTIVALVAHPDGATWVFLRKLRDGMYTLLSTSSAWGAWIFYDCGALFSSVLALATFVALFLLAWVIRRTLAPRPKPEHATDKKKKKRKPPMHPKGNNYRGGRIPNATAIVTTTTTTNPKHNPTTTESVPNDAGTIEVCASEESHRLEEQKEPSVTERQSEYDRPEIRSTLLPALSEDKPLDPSPFMSPNTLSPTIPDPETLVTEDSSRNRAASGSTVDTAILSDDMSYGSGSTTRTLPTAMPPTEHPTVVPMESTLCKGKNVAMNEPESIPKRPSRRGHKIGSSAVATCGPPQTQSGAKGGSATSYQRSIVSPSSKERNTNRRRATRKKRLTASPRLTRRAASGSETSIAIPGIQSNPLSPAQATPSLSPHGSDSLFSTEIPSFSPPPLLTVTTENDLRTPSLFSRSVGPAVQTPVRFSNNGGFVKSSSPPTSTRSVYGEQAAYFSTLNPQSPSWTGPVLSPPTILRAPPGLGSVVRHGTMEQTLLPSEAAATASLSSSHYKNLSLPSVPVAPRGCMIMSPSPLFGTPHPGPVYGSVKENPFADEDDEQIAADLQELGGRMVGSILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0B4</accession>
    <name>B7G0B4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180446.1">
        <property type="nucleotide sequence ID" value="XM_002180410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0B4"/>
    <dbReference type="PaxDb" id="2850-Phatr36077"/>
    <dbReference type="GeneID" id="7201256"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36077"/>
    <dbReference type="HOGENOM" id="CLU_712657_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0B4"/>
    <dbReference type="OrthoDB" id="55473at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029146">
        <property type="entry name" value="Ten1_animal_plant"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15490">
        <property type="entry name" value="Ten1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="388" mass="42382" checksum="5025B7B64C3A92A7" modified="2009-02-10" version="1">MDSLNNRAPASAGKSTTVLAAKVAVTNPYACKKAPPPISLKPLHDTPAPDFPDESETVTTALKTVSTNPETTCTRNVQKQKDSESARDNKDSKTTSINDSTPLIEEIKKTQSSVSLPQWQRLPSRSISFGSAEILTVPECYRHFKTYLGRSVRVTGTVLHRHVHDDCMISLVIGDPLEQLHRQSDLKRRLSTGSGDSIANSGTPKTPGTATKRKSSQEETPAISSSKTKRFVKKTPSSNTNSLLQRQQHGGSNLVGVNQPLTAIKRTPLEAMVDCLSRKSNCVWIMVNPDHAPVHQCAVGDLMMIIGELRLMSSSSNGPKSTLVLASKISSSTKDTVCYLEARILRNANGTNMKLYEEALSIRRRFLQKQSNPISEVDPPYGWGPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0K0</accession>
    <name>B7G0K0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_36162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180692.1">
        <property type="nucleotide sequence ID" value="XM_002180656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0K0"/>
    <dbReference type="PaxDb" id="2850-Phatr36162"/>
    <dbReference type="GeneID" id="7201300"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36162"/>
    <dbReference type="HOGENOM" id="CLU_1047534_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0K0"/>
    <dbReference type="OrthoDB" id="55810at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="266" mass="29791" checksum="058FA6C1FF6144B1" modified="2009-02-10" version="1">MNTRPSIEINNKAVSCIQNGQSKEALELLRIVLADLKDQFAASDNNLFPVSSSRCTVPVIDDFSSTPCVRPYTHVDSTFELSRTASYNSYEHGPDAMMEAVQARSSIRPVPVLDDILLQQSIAKEECALCIYDQALLVSLEEQDGEVITSVILYNMAFVNHNRGIHRGRTSFLCKALRLYKMSLDILLKSDCRSHSIDILLLALFNNAAQIYSQLFDLEEMRQCLDCMREVLASDPQESSESDQLGVFFLNTIFYPGEEFTLAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0P2</accession>
    <name>B7G0P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180708.1">
        <property type="nucleotide sequence ID" value="XM_002180672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0P2"/>
    <dbReference type="PaxDb" id="2850-Phatr46277"/>
    <dbReference type="GeneID" id="7201481"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46277"/>
    <dbReference type="eggNOG" id="ENOG502S7D2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1274443_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0P2"/>
    <dbReference type="OMA" id="THATPIN"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="217" mass="22989" checksum="E111CA182429CC5E" modified="2009-02-10" version="1">MMNGTTAERNGAAAGIQTCTKDNDVVSSVSDSPESVAEPTATAPTADSVPDANTTPNPIVSSTKKSRPPYQYDPHKITLRFLFANRDGLTVTVECEPNDTVGQVKGALLSVWPTDLPTCDGSDRVRLICMGKGYLMPDTRTLEDCQIPVFKTHPTPVNVSVLPVDNAVEEAHGKKDTRKKKESTHTGGHARTNAARSPTNDGAATAAVNQGCACILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0S8</accession>
    <name>B7G0S8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_46310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180725.1">
        <property type="nucleotide sequence ID" value="XM_002180689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0S8"/>
    <dbReference type="STRING" id="556484.B7G0S8"/>
    <dbReference type="PaxDb" id="2850-Phatr46310"/>
    <dbReference type="GeneID" id="7201500"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46310"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264136_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0S8"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05145">
        <property type="entry name" value="RIO1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="686"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC48133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1269" mass="140053" checksum="EA6B49049277804A" modified="2009-02-10" version="1">MFPSHRHPFPPSTGSTNNVRDGGAANELVITPADRTLQGPKYISSDAVSFGSGWTANTSFPCVFVGERRHQTYLERIPYVPDKAAWKRFRLSCSIRETPYVVFRRFRHFCRNESPLVYQDIYYVRPESVPPQPTNNLQADGIGAAVPCGTPNPFCVVPLYASAPVAATHRDTHRRKAFHRSRAARADNPRGTTTPGTVSRKSKVDRSYKTHYKKNVMEDDLRNSTIEHSDQNSSQDALEHVNESHNDASVNESHNDALLFDGELHDTTEQPKELPLPNKVDEHNELDLNDLRSSTHNTNLTATSLQESSYASLNVEHLLAEMDCAAPPEMTTPGPRHAPWASAPSSVPRQPSLRDIMMEQQQRQHQAEKSSLLMVELAQEEELIRIALERSLTDVGSVHSATAASTRTAPHESHAPPGDPQNAQPAAVSERPSVRKETQVSKTDLSAVEVSLIEQALREGIRRHQNDFHHNASLPQKPHPVARMLATLHEEETTVGSSPNEDDDLSPEALTDSDPEPSLDLPVRPSSTTLSSSPPTTPAGQGSLQNLEGSHKDSSPLTTPLSSSSWRLREGQYACAGASPASTSVSVTSSWTPRDAASPDNGISPASTSSARSAGYNYRSPLVQHLGPSFQRLEELSSDELLLVDSARSISGASSAMESSSATVPRHAVRDPLLGFTYLDEYRNTNESQSQEWDGSEVQQRQKALRASQSSGLSAGPMLAPPSADMPLPPVTTLRSVSTAVTTASTAADSETSITGPATANQSFADDYDWRGAEHHLSAEEIRSIQQALTDDDTWQENSALVDAPEAGDTHTDTQNGELSAAEAEAIERALREADEESERDSLLLAWQMQDEEEARQRQQVAARGTQQGNIRTITRAELRAEQSGRFSTIGAVHSSDPPVMRHPLEDEEEVQLAAAGFRMNSTTRQEWSRRDQHSVVGPNNEVRTKHDAELHEQANAHRLGLDTDEHGLARIGNKAFNSFLHSVRRDKKKGVATHGTGRAGSDTDATKGGAMDPAVRMQITRAINSGLIERCNGVVKEGKEAVVYHAEKGEESEGFDVAMKVFKRIQEFKGRGDYVEGDPRYARANFRKASNREQLEIWAEKEFRNLMRAIRAGVPVPTPLLQKENVLFMRFMGMNGWPSPQLRELDLRKGSKKWTTLYTQVMEAIQRLYTKGRLVHGDLSEYNIMVVPAFLVDNPSTYVENDQDLQPVLIDFGQAVDLRHPEARPLLERDLDRVIAFFKRQGVETMRISDAVSFVVNEAELKPINVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G164</accession>
    <name>B7G164_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180798.1">
        <property type="nucleotide sequence ID" value="XM_002180762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G164"/>
    <dbReference type="PaxDb" id="2850-Phatr46428"/>
    <dbReference type="GeneID" id="7201786"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46428"/>
    <dbReference type="HOGENOM" id="CLU_746937_0_0_1"/>
    <dbReference type="InParanoid" id="B7G164"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41854" checksum="3DB6BA2ACD97B45A" modified="2009-02-10" version="1">MPPFTVRAPYTSKPTSSNCLPWTIVYLLLIIVASQWALLNVALNRPDIKKGYESHSLPLRQKESVHSTIPQSNREENVTKNQGTSQLEAEIQGVFTTVLFRAPKWFHLRYLGILHNALSNLPPHWKLHIFINEEWIRSQVYPWQSGLQRFLMDPPSRVKVTPLPPYLTRGKPKQILVDQWFWNSLLADHVLIFSGNGAFCGNHMDAHIWNELNLLDYGGTPWSMGVGGDGSSHSIRNRHAMLKVIVYANSTGKPLNPLSGREHDFFVNTMKEMNEKNLARFTLASVEQTVRFGGVTNLANETGTIHVPLVAAGTQARLSYEERDSLLKHCPEIKMIFPSLHEPACFGAHPNPEKCRASICALQDDIPKHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G195</accession>
    <name>B7G195_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_46448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180814.1">
        <property type="nucleotide sequence ID" value="XM_002180778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G195"/>
    <dbReference type="STRING" id="556484.B7G195"/>
    <dbReference type="PaxDb" id="2850-Phatr46448"/>
    <dbReference type="GeneID" id="7201549"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46448"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_991961_0_0_1"/>
    <dbReference type="InParanoid" id="B7G195"/>
    <dbReference type="OrthoDB" id="46527at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="131"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="31711" checksum="51A49DCD8E1C0C1D" modified="2009-02-10" version="1">MKLSTYTIFAALPVMAAAYNMGGYRFARPLYVRGVRCEPSTRGKSQCQPDPVDQAFQNLENQVTGNARGRRRRWKNEEEMLRQQQEWVNRAFGLASEVASKVNANKGEVRDEVLRQQQEWTNRAFAIANDVATGRTTPRYEVNDDNEAFSVALDVPGVKASDIDISVDEEEHVLMISGERKVGRGEDARVNKFSKSFSLDSSTQTEQLTARLSNGVLMITVPKEFKKKESTVRKVAIVEVTDDATPINEVRNKENEDPPVSEKDYVEKDDAEDETKPTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1H1</accession>
    <name>B7G1H1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_13095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180856.1">
        <property type="nucleotide sequence ID" value="XM_002180820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1H1"/>
    <dbReference type="STRING" id="556484.B7G1H1"/>
    <dbReference type="PaxDb" id="2850-Phatr13095"/>
    <dbReference type="GeneID" id="7201591"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13095"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_23_3_1"/>
    <dbReference type="InParanoid" id="B7G1H1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="97" mass="10815" checksum="08CB0BAA9F794E5C" modified="2009-02-10" version="1" fragment="single">DNYSIYVGQVDYSTTPEELLAHFEACGTVERVTIVCDKFTGKPKGFAYLEFENESSVENALKLDESEFKGRQLKITHKRVNQPGMAGGPPRGRGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1P6</accession>
    <name>B7G1P6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-contain kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180892.1">
        <property type="nucleotide sequence ID" value="XM_002180856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1P6"/>
    <dbReference type="STRING" id="556484.B7G1P6"/>
    <dbReference type="PaxDb" id="2850-Phatr46573"/>
    <dbReference type="GeneID" id="7201710"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46573"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014380_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1P6"/>
    <dbReference type="OrthoDB" id="197174at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="694" mass="78485" checksum="942875DF07616A05" modified="2009-02-10" version="1">MSLPRSAIVTPALHEMYMDEHSMVQMGMVVRHNNLGVACIESGAYERAGQYFRRALDKASETTFFSLPQSESYIKPGEVSRSLYIYQRGEYDEGMHTFSDPFFLDVAFSTMHSATATILFNIGQLHLRLDNNEEASASFLRALHIAQWSNEDILHDSEEGVCVMAILHNIGHVQYRSGNYEDAVRTYAKALHLAKNAFCKNSHRMLEVAATLNCLGVLYFHLPKAETERAMELYVESLAIRNAVHGVDCESTEIATTLNNIGRIYYMKGEHDKALELYRQALRMRRSLLGSEHLDVAATIYNAGQTHHQRGDLVEAMELYKEFLSIARKRLGIHHRDVAIMLKCMAQIHHERKEYESAKQFYEEALSVGKAALGNYHPEVASTLNKLGNLLYEKGDLENAIRVYKSGLEVERAVLDVFHPNVVVTLTNIGQIHKLRGEYQAALRLYKEALAIQRNSLGAAHPNLSATLSSIALIHYQTRSFSKSLDVYQEALRIRRDAYGDNNLEVASTLNSIGLVLFKMEQHELAMQSFQESLRIRREVLGKDHRDVAIILYNIATIHMEIGNDDEAMNFYRETLRVERTSLGENYRDVVLTTQHVGQVHQQRGELTEALYYFQQALDLQKAAPQQNYGAIAQTLNHIGNVLLQRGDAQGLVHAFSEALRFLRLGGKSNDELTVSGFNFYGLSKMHPECAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1Q4</accession>
    <name>B7G1Q4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_36568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181073.1">
        <property type="nucleotide sequence ID" value="XM_002181037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1Q4"/>
    <dbReference type="PaxDb" id="2850-Phatr36568"/>
    <dbReference type="GeneID" id="7201714"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36568"/>
    <dbReference type="HOGENOM" id="CLU_2008370_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1Q4"/>
    <dbReference type="OrthoDB" id="57212at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="124" mass="14149" checksum="A6B5D907C20E37BF" modified="2009-02-10" version="1">MSPENNGPLLIYRFTDFKKDDILYHGYILELQDVDLRFGEPNFVAYFLGNNEVVVKYPSTSYTFLYDTDVEAAGRRLANLVDDRLEQTVDVARNQIASDPARKFKHLLLTFPSKPNKAGAYPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G234</accession>
    <name>B7G234_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="4">3.1.3.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_13606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.99" evidence="4"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181142.1">
        <property type="nucleotide sequence ID" value="XM_002181106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G234"/>
    <dbReference type="FunCoup" id="B7G234">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G234"/>
    <dbReference type="PaxDb" id="2850-Phatr13606"/>
    <dbReference type="GeneID" id="7202097"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13606"/>
    <dbReference type="eggNOG" id="ENOG502QR24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G234"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="338" mass="38414" checksum="97EEA96EDAE37C0C" modified="2009-02-10" version="1" fragment="single">MSEQNNQQVSRLQQLVPTIGMFHTHLPLRRAFEVYNEKHKLTKRQHIQISFNEIRHILNLAQIMALRKNLNGPRLITFDGDQTLYADGANFDSNPRLANYLYLLLRHGVSVAVVTAAGYEYNVEKYEYRLSGLLHFFRQRGLSNAECARFYLFGGECNYLFQLGHGYRLQPVKEYGPGGWITSTSFIKESPGNWSEAHINTVLDLAESNANETLKELNLRGRIVRKRRSVGLCPNHGQEIPRESLDELVLRSHEKLNRMNEGTGPGIPYCAFNGGTDAWVDVGNKRVGVQVLQSYLGIPVQETLHIGDQFLNTGNDYAARDVSCCVWIISPQETTYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2C9</accession>
    <name>B7G2C9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Drug/Metabolite Transporter (DMT) Superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181185.1">
        <property type="nucleotide sequence ID" value="XM_002181149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2C9"/>
    <dbReference type="PaxDb" id="2850-Phatr47075"/>
    <dbReference type="GeneID" id="7202160"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47075"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025028_1_1_1"/>
    <dbReference type="InParanoid" id="B7G2C9"/>
    <dbReference type="OMA" id="HGANEDF"/>
    <dbReference type="OrthoDB" id="300580at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF3">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53149" checksum="3C238F4E95E14CC2" modified="2009-02-10" version="1">MGGASNDSSSSTTRCGVFELSIFVAAIVSGTACSICSKTMMELHGVGIDGTMELFTKPIFQTFGMFVGMMFGLIMHWAVLVLKIPFPGYEHTSALDNDQRPGYNTTSTNYGAIQSEKDQLLASQASTASTSNATPVWMYFFLIIPSIFDLGATALCMMGLRYLDVSIYQLLRGSGIIFVALMKQHVLGDRLFFFQWLGVFWNVVSVILVGATAILNSNDDVDLDPNDAFWGVALVMAGAFVQALQFVFEEKVMSMEDAAAPPLLLIGMEGFWGTLLCLVVVYPLAYYFPGEDHGSYEDPFNTYEMFMNSNTIQWSFVIYFFTIFAYNLFAVLVTFMLNSIWHAILDNFRPITVWLTDLMIFYVITETGDFGEPWTKFSVVQLLGMFVLLYGTAIYNAPNAGSLKLEGQWYSFGFNLRGEYEEIELEIHEEELNREWEERQQNFKARRTSSLAERSPHTSIHTQALRGFASPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G325</accession>
    <name>B7G325_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_21538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181714.1">
        <property type="nucleotide sequence ID" value="XM_002181678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G325"/>
    <dbReference type="STRING" id="556484.B7G325"/>
    <dbReference type="PaxDb" id="2850-Phatr21538"/>
    <dbReference type="GeneID" id="7202509"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21538"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G325"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="256" mass="29776" checksum="0230CECD6B2E6133" modified="2009-02-10" version="1">MSSLRNAVKRVTHKERAQPQSRAHLGILEKKKDYRGRAQDYHRKEARIKAIQEKVAMRNPDEFYFGMKNAQVLDGKHRKTLEAKQKEFEADVGLDTVRIMKTQDLGYVRMQKQRDAKKVERLQSSLHFLADNSESKKRKHTIFVESRQVAENFNVAEHFDTLPELAGRTFNRPRKQTVQEIALRASGSGSEVGEARIRGAGYKEMEERKERVQKLERAEAHLVTEKLVQGKGRKRKIKAAENGQPAQYKWRRKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3F0</accession>
    <name>B7G3F0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_14064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181776.1">
        <property type="nucleotide sequence ID" value="XM_002181740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3F0"/>
    <dbReference type="STRING" id="556484.B7G3F0"/>
    <dbReference type="PaxDb" id="2850-Phatr14064"/>
    <dbReference type="GeneID" id="7202571"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14064"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786348_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3F0"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="161"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="177" mass="19632" checksum="82B62D78DAA3923F" modified="2009-02-10" version="1">MLPKFDIEPPLPPNLNKWYNQLKNTDPVFEKVHDEVMSGLNAWEEKNRWHPILGAGWRDEEPATIFDKLMSGDIPATVVKQDDKIFAFKDINPAAPAHVLVIPKDRSGLTRLGKATEEHTEILGRLLVAAAEISKDKELGFGDGARIVINDGPDGGQEVPHLHVHVLGGRSMQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3R9</accession>
    <name>B7G3R9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein arginine N-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_54710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181483.1">
        <property type="nucleotide sequence ID" value="XM_002181447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3R9"/>
    <dbReference type="STRING" id="556484.B7G3R9"/>
    <dbReference type="PaxDb" id="2850-Phatr54710"/>
    <dbReference type="GeneID" id="7202308"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54710"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3R9"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000132">
        <property type="entry name" value="Protein arginine N-methyltransferase PRMT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF68">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE PRMT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="181"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="410" mass="46021" checksum="8E769578DBDD79F6" modified="2009-02-10" version="1">MSSSAPETPFFVNATAAGEIPSYNGDEKAKATDFANYFCSYAQLYHQKQMLADHNRMAAYHSAILGNQDVFRDKVVMDIGTGSGILAVWAAQAGARKVYAIEYTDMAKHAERVMKANGVDHIVTVIQSSVEDVVLPRCVDIIVSEWMGYMLLRESMLDSVIRARDKFLKKNTGLMFPSHTTMFVAPVNDEDERKAAANDYGSSMSDWAEFAQTTNQVYGVNMDCLEKEFDREQKEYHMLSSRWTELPPEAVLAEPAMIKQLDMTTCTLQDSRGIDKDAEHSAFDFEIDGDEINNPISGIAGWFTADFRSRTDAGGRDAPKLSHPAFLSTGPENGYTHWGQQTFYFLSSIPILKGEITRLTGALEMMRTKENSRLYNCRLTYSTSRRRNDEPQDGSVLMKSGKIEQVYQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G459</accession>
    <name>B7G459_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_21744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181858.1">
        <property type="nucleotide sequence ID" value="XM_002181822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G459"/>
    <dbReference type="STRING" id="556484.B7G459"/>
    <dbReference type="PaxDb" id="2850-Phatr21744"/>
    <dbReference type="GeneID" id="7202801"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21744"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440393_0_0_1"/>
    <dbReference type="InParanoid" id="B7G459"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="149" mass="16928" checksum="974E3F903CE6C6A4" modified="2009-02-10" version="1">MLVQRLPSAQQEEFRETFQLIDASGDGLISLLELKRVMNSIGETKSDTELLAMIENSADPELAGRDEMNLQDFMGIMAEAEFYHLFRDIFSSLDTNDSGFVKARELDQVLSGVRDLISDDHRSIIDVEDKDMLIDYEQFSRMLLGTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4M4</accession>
    <name>B7G4M4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182099.1">
        <property type="nucleotide sequence ID" value="XM_002182063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4M4"/>
    <dbReference type="STRING" id="556484.B7G4M4"/>
    <dbReference type="PaxDb" id="2850-Phatr47712"/>
    <dbReference type="GeneID" id="7202894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47712"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420108_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4M4"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46069:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46069">
        <property type="entry name" value="TUBULIN TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="645" mass="72122" checksum="C302C6E734804AB8" modified="2009-02-10" version="1">MIADVATTIATGPTTAQTKALIVCDMQPDLLKSLPPARRQALLDTVIVTVDAVRKAPPSKIIWTGVRFLDPTFASEVSYTHRLYGALRRLYDSAPKGTVQWFVAGTYGTAIDPALLPLDEQDRPHEDNDQDIISWRSQHLPLELAEIVKSQGIVECTVVGYKASYAVQATCQVLCDASIPVQVVIDAVEDDNSARRQAVIKHLLPIYAECMDLSTFLSNTVDMDSYQVPPQLHRGQKPLLSTSSDEYTKRSWTAGAVRYFADCGRGGHGPIYRQHLMQQPWPVQEWYADHLRGQTYRCPVGKRVVDFCDEPQFSGIAMFLKGREWLDEKEKLITLRYDNTILQIPPTFVIRQGQWVDAAPPTSSAASEICWFLKEVIKNGGRAVQVCPSAEDALALAEARNNYVVQAHIPSPLLTDNGRKCHVKFYSLVTSDHTNGWNLYTYKDGFLSVSPNLWSAGDLSAETQITVKRNVRLQFSPDSENNQEGAVSAAPMENWTAAGSWPILYGRCRDAVRSMVRVAIDEGKLMNRPPGRSQFEIFSADFMLDTEGSVWLIEFNFTPVLFDPLYHSHDPSRLTTDGLKRYHAEHLEMGDTAPINDHDMIRDAVSIVFDGIPVKPGLTKWEHAMKCDDKPYHECLSPTHPIDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4T3</accession>
    <name>B7G4T3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181970.1">
        <property type="nucleotide sequence ID" value="XM_002181934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4T3"/>
    <dbReference type="STRING" id="556484.B7G4T3"/>
    <dbReference type="PaxDb" id="2850-Phatr47759"/>
    <dbReference type="GeneID" id="7202923"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47759"/>
    <dbReference type="eggNOG" id="KOG2491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355455_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4T3"/>
    <dbReference type="OMA" id="HIMIVND"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="87620" checksum="E59E100F9F61C283" modified="2009-02-10" version="1">MNLPGNADFLEKASLMEPLLSITEKAINVSSIPGNDSFNAPTAALRGEQFEIALRRHVVKAASKVTEKGVSELDELGVFWDLCLKVCLHIMIVNDKALVDSSAADPRYKDMSVRKVPFVLLEDILDVLSSPLALQFWSSRVRPSYDFLFAPTLWSPIRGDSAASPSHPCWLPFLKISQKFLRRLVPEAAAPILVQLSTVYPLSEKSATKVWGSHGESTTEYDSLEDFHKEEQSITLDTTTPNGSSSSVYDYSFYESFWRLQEDLSNPNSIKVAGFLSRVRSMMTAFENQTCDTNTSQDSPINLYGHYLTSSRVLAIQLLDASFQIHVLTQFLIVAKHLMAQVPVLESQLADHVTRAKNRLQLELGDAGRHQLELLHHLWQGSESLWRDWKRKKCPADIDAPKLALSAAGGSPPRKRLLGALGSGNGESNDADERNTDYSLAQVHDELPALSKRMKRLAPDLYTHLQDYVEALDPDAGIEAEYHPKNNALFGWRALRLLSVDHLGEFNLLDRNGDCEGLVRTIYQRKGIVIPGKIPESALDELEEFEAGDPGVGNDDSEGNTDTLKEVRGVMEEDAENHLDSGDDHVEEKVGVPIKVEQPSIDTEDRVDTSHKVETNLKQSSSSPHKQTEKLVLESTLPRETGGQIAKSGDGRMTQSFVQEGSKEGSRKRSRSPVRSEDDRSRLNREESRSRVRDHGQRGIVDLEGRGGGKGNGGSSRGRNGPGHHGMYRQDQGGRGAGNNRPLLPRESAPRDGPPPLRDGRARRGGDNRHDDWRGDERQGGGRGNHRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G544</accession>
    <name>B7G544_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_29097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182350.1">
        <property type="nucleotide sequence ID" value="XM_002182314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G544"/>
    <dbReference type="FunCoup" id="B7G544">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G544"/>
    <dbReference type="PaxDb" id="2850-Phatr29097"/>
    <dbReference type="GeneID" id="7202981"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29097"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="B7G544"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="6">
        <location>
            <begin position="67"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="25379" checksum="59E2DC2C49339079" modified="2009-02-10" version="1">MAEVEETPMEEQPVEEPQEEFEEEEEEEFVVAGGATEIKLFGKWSFDDIEIRDISLVDYIACKGDHATYLPHTAGRYQKKRFRKASCPIVERLACCLMKKGRNSGKKLMAVRIIQHTLEIIHLLTDQNPVQVVVDAIINSGPREDSTRVGGAGVVRRQAVDMSPFRRVNYALYLLATGAREASFRNLKTMAECLAEELINAARGSSNSYAIKKKDEIERVSKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G548</accession>
    <name>B7G548_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182184.1">
        <property type="nucleotide sequence ID" value="XM_002182148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G548"/>
    <dbReference type="PaxDb" id="2850-Phatr47849"/>
    <dbReference type="GeneID" id="7203077"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47849"/>
    <dbReference type="HOGENOM" id="CLU_759647_0_0_1"/>
    <dbReference type="InParanoid" id="B7G548"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="305" mass="33828" checksum="B60416A917CBA7E9" modified="2009-02-10" version="1">MTETPHSEDCPSPRSHGLHIFPIRNRLFTEETVPVRNHAAVCFTMTHENPFKSPREATDVLEADAVSHVSSLSSDSRRRNNSRWNGVDMTGETGTGALLLPHEIAFFTPRTPSPEWLAGDERDNGEGFTLMMPPPPSHKVPTTTVRPSPSLPRPILGKFRSTPIFPHPSSISPIFEGRIRTSVADQSLISQVTEDDTLSLLGNRPRRRPVRGSSSAISVGSIVGQSSLKTVPTLATVSISEQSFTHQIKAQQTLDSLVAERSPMRHGLVKRELHYMFKSVSSPLRRFQQSRQKVDLQRTNKGCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5K7</accession>
    <name>B7G5K7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_14467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182433.1">
        <property type="nucleotide sequence ID" value="XM_002182397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5K7"/>
    <dbReference type="FunCoup" id="B7G5K7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5K7"/>
    <dbReference type="PaxDb" id="2850-Phatr14467"/>
    <dbReference type="GeneID" id="7203228"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14467"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085890_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5K7"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="89" mass="9658" checksum="5D28DDCAA553E1C8" modified="2009-02-10" version="1" fragment="single">GGLGALAGWGMSGAAIYDATIQGPEVISLTMTPVLIVYSSLFARWAWVVKPQNLLLCACHVTNVGAQLNQLRRALQYKIENGQEEQVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5S4</accession>
    <name>B7G5S4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182303.1">
        <property type="nucleotide sequence ID" value="XM_002182267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5S4"/>
    <dbReference type="PaxDb" id="2850-Phatr48042"/>
    <dbReference type="GeneID" id="7203255"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48042"/>
    <dbReference type="InParanoid" id="B7G5S4"/>
    <dbReference type="OrthoDB" id="45673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="103" mass="11345" checksum="49BCB1B4F442D467" modified="2009-02-10" version="1">MGSWAKSATTESSRLLTLDFPFCVVFAGQKNALRTLATESAVVAPEKKTGAGLWQRLTSFIVGAGLTGVFTQYYIFEEVKNGNLLMLAKQKELETRIAKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5T7</accession>
    <name>B7G5T7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182464.1">
        <property type="nucleotide sequence ID" value="XM_002182428.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48048"/>
    <dbReference type="GeneID" id="7203409"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48048"/>
    <dbReference type="eggNOG" id="ENOG502QU3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224479_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5T7"/>
    <dbReference type="OrthoDB" id="39934at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1750"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2013"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2101"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2143"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2255" mass="253815" checksum="CC2336E5F629288E" modified="2009-02-10" version="1">MSGTPDHPHDPADVAIQQGETNKLSLSNPTSPMSMDDEQPFPHTPIEDSDQSRSSAAIFVSRVSQPLVTLPPSSRHLARTAGSSKRHEGGENPVWLAQPPSVSSISHRNICDFGNKGFDSDRGWYLRESCLLSMEVGSQRQVVSTPCRRDCNGQIMPVAVQSPLISRDESFFRDRKKVLQDAMSERSKYDIQLNNEVGALGGAWRGIVRRFMLWAFDNVNALQLSRALQLQLPFQTGYESYLTSQVIEALDRGDPSEVADVLSAAFLNRNVSRVMVQNLGPRYDLLWHWSTAITWNRAFDAWGQFPLVGITGFPATENFPSTRNHALASIFRVLLGQGNWITRVVTQGREGILTDNPNNKAQNLAPESNGFELANRNQYGTYFGRVKTNEFRYAHRLPTDESIVRTFVASPMATMSNNGVVHVLRMLDKHWHNMLSQEWGNFAHQRMEQLDPFETLRFHMPLVLVTLSNLRGRNAWDAEVLGPAVRKLQALKPGLDTAAAWKLAKELVDDVAVTVSGGVASVFVPLRSWLKAIRESLDRLERKAGEVLKIVSSVEMGIRLGHDLVTQVSWKVPSDSVLKAAILNHIRGKDKQAVIANDQDAADAPDANAVDSWRIRSALQKTTPRDMRTLIELVKGNLEHMKAAQLLIGRVKTLLQRELRRGYLNQAIRDLSKGPYINGPLMRDEWYWLEEEHGQGLHIYIGKIPDSGLHQFIHVDSGNDKTISLSNGKVLARAYIPVPESISRAQKAFMTIELEYGKTFKYSAFMEFSMLRIALQRLVVVSQMNCEELDNARLNVLREIQRSKQTVLGPEDLTPGNTYYTFDESKRQYIPFLCEPTNSVSTQSKRAKYVRAPPQSVLVVGGGPTGLLTTIHCAEACLATGGAMKLQEARDAFAQGGSTFERAQVVRLDARWISMLRYHLGTIFEDVYIPASGETDAQLGNTLPTQGFVEITIKDLESSLHTEASRLWSRGIIFVHTDSKARYDATSNSMIKQGKNLKDGDVVLRPVDSHGKDSSHFHSWKVSEVRYTKVLGIEDLKVGEEYGVWIHQEQKVLPYTLVAVDLDTELYTFRSHSKDKSKLCVNAKNLPSIYPPGTTTKAHAGVREVVFEGLGNRQEGELPKQTVPFDPIENVNFTLDLGNTHVVEAIGKQYPSDVHIGVTTKEPYGVCCMQGLKVSMGMHNFGEKRWGTGILDDIRSQNDQNTRIIGDFTKMVRVVPIVEHMYQTISKDKDWRMHFSNVIKESGFPEVADLQPVLPELVEGCRLLSQASLNFRRKTLQTRFFETGDNYYLGMEFPREYDAWKNALSFSLVKKLSATGINSRAVERLRSFLMHHIDRLWYNGCLETIRTGDVYNPGARERVPRLYLINSYMEMSLSALPIGESFRLVSDPQSKYEVLAISSSTILVRNVEGYLSKFKKSTKVLREGNLTRGPDGNQESKVALATFDVGHYVNHRTMRLLNKDQGYVFAFIGDEQATPHFMRYSGLTGACINAMSFNNFITDAGRGVSFEERLQQYSEETDWSNGEVVQRGTGANYGDDGFLRPGFSYRDGVAFLYSKIVEFGEMGKDVNNLLTRDWMVKLTASLVPRGMELNRVFLEGLQRHWKAAVFDKLMASVKSDIPVDEKGANVVDALRSSSSTLVEKNAASPVYWDELTTSLQVDTATRDVLSTRHFPVAKRLCEIINELIDFASKAYVYNERISSELSNQPKSVDSLIDDFSVEAQNFANSLTQSAAFAAGVLAFRLVGSNVANTFSAVFAGLNILIAFGTMTNVSRYKIRNEEWRVFFADQKFSGVKCAVFALLSKDDQDSTPLEQNPFIDILEKRVKLFREAAGYYGYSDPTEFDEAYQQLKSRANDASELQKFRDLLVTDLLVDTYHVNSYVQEKLVDVFRVLDEMIFLLDSRKSKSASKAKQLFDQLLAYDSVLEDSLQRGPVRFGFIKQRKFLHWNLIAAVRYLGKVLCCIPRSCQSDRALFQSGTLGIVRSLQSLSKEQDSKVLRRESRDFETLLWATRESEIASLIFLSGFFVFFASVLFSVARIFNIDSLENAAFWANAVSSFGAVLAAFHLVRKFSILFGLWVTLWLKTSSTEGMDHINIRRIRDVTSIQALLTLTRLAAASGAAVALPWSVIENAFPSVITLDEDYPFWLASGAVCAAILATVFFFVVEYVVRYNLSPQLGPFVSELFRDEIETMFNDLAQRQNDIDTKVVQDRENWEYVAREFLHKYRFDTVFAADRFGTIFQYIQAGMEGSSDSKIEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6M0</accession>
    <name>B7G6M0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182593.1">
        <property type="nucleotide sequence ID" value="XM_002182557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6M0"/>
    <dbReference type="PaxDb" id="2850-Phatr48289"/>
    <dbReference type="GeneID" id="7203384"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48289"/>
    <dbReference type="eggNOG" id="ENOG502SVQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010608_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6M0"/>
    <dbReference type="OMA" id="TIMERPT"/>
    <dbReference type="OrthoDB" id="56122at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="589"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="851" mass="95262" checksum="38F85739165CDF9E" modified="2009-02-10" version="1">MTLIIKPFIREDENAERYVPIFSQIIKSTGKQFESNIMEHILQYRELEATELQLIKLVKIAEDWLTQYARIEVAEVPANLRASLMLYEGVEVNQVAQNTTFSMRENVSVLSKELKKLLCFLWRHDCVGTGIIVKTRQELSDLLELSESSTQIIEGGLIGKLLVDILLENPASTSQCPLGCVYAAARCFFISKDQLVLRSADASASQVATIMHLFRLAYCSVVGTVSHPLGYIEGAKVLVKTIMERPTMNTLGPMIRHLREIQMQKPKIVDRYFSRNGEIVVQGLIFKPEIWKTLIPRVVSAARLVLSQIFDGKDWEVFLTTTLPLLNVGISGGADEGVQFQVQQAGGDVFSESLKLSPQLNEMDQDHLSSIVEFCLHGLGLGSMRYSETLGLQDFQVLWGDGALYFYAKSTKKWKAQSKLSTELTQHKLPKSISRIVLLFRLVISLRGGDLSSFVPVRSDRKYLMKDFVQSLFCLPRAPDDLQVRHFFASLSNYLFPMQDDGKATTSDMVAMQSHHAPSTHASTYFTHRKAHLEDYYDAYHFHLGDKDTQWTFDIPLDVLPENTIVAALKILYGGEANWLSETQRSMVLTWSTLSKNVIANLPCGGGKSAVWEVTAYARHRVGLTRKCAVVVVPYKFLAYNHYHSAKSKFELLDGVSVDMLESSAVCSNQVPTILKSDVLPHILFLTVDALAKLLEFHLPIVQSMQSRLAGFVIDECHCPYTETFRPVFDCLQDLTMFGVPICALSGTLPSTFPSSLMKYYGVSAFETVADSDCIGDGFSLSIKQCHDEVAAVTRKVVQERNQNSRSAIHIIAASARVAELLFQQLCSKSFQCLLVTSLRGGRTQSSTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6X1</accession>
    <name>B7G6X1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_15083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182805.1">
        <property type="nucleotide sequence ID" value="XM_002182769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6X1"/>
    <dbReference type="STRING" id="556484.B7G6X1"/>
    <dbReference type="PaxDb" id="2850-Phatr15083"/>
    <dbReference type="GeneID" id="7203639"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15083"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_5_0_1"/>
    <dbReference type="InParanoid" id="B7G6X1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="135"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="374" mass="41385" checksum="4E747F7FA2E45723" modified="2009-02-10" version="1" fragment="single">SPVVVAIWKGRDEGLPVLVLNSHYDVVPADTSAWTVPPFAGLQRDGNIYGRGTQDMKCVCIQYVEAIRRIHRLDPTWQPERSIYLTFVPDEEVGGFGMAAFLESETYRSLPGIALALDEGLASTTDTYSVFYGERLPWWVDVTAHGPTGHGSRFIENTAVEQLVELANKALAFRDGQRAQLGLDEHVNCAHAVAAKTLGDVTSLNITTLQAGVRVGETFAYNCVPPKAQCSLDIRISPHVEPSEIGEMLDQWCRECSKDEKNKVEWSFLGNGNDMKKHSVTSTDPNQNPWYAVFSKAMADMNLKFEPQVFPAATDSRFLRALGIRALGFSPMKQTEIMLHENDEYIPESIFLEGIDVYVGLIRSLGGIGKDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Z7</accession>
    <name>B7G6Z7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II DNA topoisomerase 6 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOP6B</name>
        <name evidence="8" type="ORF">PHATRDRAFT_38840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182945.1">
        <property type="nucleotide sequence ID" value="XM_002182909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Z7"/>
    <dbReference type="STRING" id="556484.B7G6Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr15042"/>
    <dbReference type="GeneID" id="7203590"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38840"/>
    <dbReference type="eggNOG" id="ENOG502QQC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006403_1_0_1"/>
    <dbReference type="InParanoid" id="B7G6Z7"/>
    <dbReference type="OMA" id="VYRGNPF"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000050">
        <property type="entry name" value="DNA topoisomerase 6 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003218">
        <property type="entry name" value="PRK04184.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase VI subunit B transducer" evidence="7">
        <location>
            <begin position="384"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="682" mass="76161" checksum="FB05B6105ED8CA7B" modified="2009-02-10" version="1">MAKTNGVASKASAGEVQVQKSPAEFFAENQAIAGFDNLGKSLYTSLRELVENSLDACESIHELPEISIEIKEYTQEEFNALDVMKTSPRKKRDMQLFETKKKDKKPPKEATDVDEITTVENSGKKRKKAPQDAYFKLTVKDNGCGMSHSAIPNLLGRVLSGSKYGVRQTRGKFGLGAKMALIWAKKSTGQPIRIMTSHRPDGGVAPERASACVLDIDIYKNAPRILEHTTRKNTDGWMGTEMSVLIAGNWTTYKSRIVQYLQQLAIITPYAVLELAYINISDSKRNLHVRYDRRSDQMPPPAKTIKHHPASVNNLVIQQLIQFTKTRTLFKFLSTELSTVSPPLARRLVTELGFDESMPPSSLEDKEITRLVQLLRQVQLFKAPDGSCLSPLGEYNLNLGIRKVLEPDLIATSRDKPGAYEGHPFLVEAAVSLGGKEVKEGITVIRFANRIPLLFEGGADVATRVANTKIRWSNYKMDYKRDRIGVFVSIVSTKVPFKGTSKEYIGDDATEIQQSVKRALQSCCQQLRGYLAKRSALKDAQTRKSRMAKYVPDVGRSLFGILDSMRARQAELSLPEAPPSQSPTKRLRLDRSAAQLMIERLNRGEVTEQSLAAKLTESIDDQLNVQEEGTDDKGSAPTQEAQPLYLVPLYNLDDDSNDISHPLFTFRPIMPILRMPAMQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G731</accession>
    <name>B7G731_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spondin like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182963.1">
        <property type="nucleotide sequence ID" value="XM_002182927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G731"/>
    <dbReference type="STRING" id="556484.B7G731"/>
    <dbReference type="PaxDb" id="2850-Phatr48425"/>
    <dbReference type="GeneID" id="7203606"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48425"/>
    <dbReference type="eggNOG" id="KOG3539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G731"/>
    <dbReference type="OrthoDB" id="43709at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855505" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="332" mass="37126" checksum="FE2146E9B263878D" modified="2009-02-10" version="1">MALRTLIPIVFAGLFFCIVSADIVVINDLIEPEEIFDFKTLADSDHFWTASKMNRTKYYCVFRNLWDEAHHPKIHALAAKPTNVVWNRETRGDTFEREIEAAGELVYSFGKGKGFFIDQDDNEENYAFLDGITVDSDFPFISGMAGINPSPDWFTGFYLLDSIDEFDRTFWNRIKIHTYPWDAGTDAGETYTSPDSDLDPPLDVERIFPQNAPDGIFVSPDGSTVHPVGEWECILHVCPDENDCERENWPPSNGCDVLKYPGCDEMCDPEVTSPCQQCQPRTSDNGSVFYPNCCESGYRPTSGDCDGNGSSASRTVFPLLSLIGGLFAASMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7D0</accession>
    <name>B7G7D0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183012.1">
        <property type="nucleotide sequence ID" value="XM_002182976.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48497"/>
    <dbReference type="GeneID" id="7203774"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48497"/>
    <dbReference type="eggNOG" id="ENOG502SMWR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237819_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7D0"/>
    <dbReference type="OrthoDB" id="44916at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1761" mass="194496" checksum="BAAF2412915FD413" modified="2009-02-10" version="1">MKGRNQDAESGKLLQQIVRQFISESVRRPHDAAADAFGKHLAEFYTTSGQIALSSETVWRALCQKNLHCSIPTAFFQYLTERILQVEPDTDPGREAMSFSFLSSWTLHIEEVVREQERGYTALSECLKSYATALVYRSEDFPDSAILDSYRRLRLVSSRSCLIDETVGHVMAEPQRFVIMSSLLAEICLDFQSPMTEKVLFTQRLGRLAWATLDTSSEITACMIVWMMTSLNLLILGVANLSSREEQIAQLNLAQSWILELLAVAQEVWCQTEKPSVHVRLRKWLYDLVSNVLLRLANQVPQYAPHFSPIVGALHPLLEEAGLVADMVMTFRLCVLTLLTSGTESQALIRMLASLRYEDQYSRSILQVLTSSHFDEDGRQSLAQHLHHSYGSLAGISHEEDPKFHLLRLLNDPSGAFFSNIVLRCDFSAKSLSPAQQLAVLLFGAAMLADEDRCGMALTYLTELVASYPHLGIQLVPVIVSHINESCLKRDFKQATRNLEFLCSALVSDPHCAHHVWNLVGIELMKKDSALSLRIAAVRLFPRLCRSNNRLYRRIIDTFGACLVNEPIELRLAVSASICDLAKDDLLRDVSDVIGWIQQFLTEDMTSPIRCLQVHYALLSLHYLVISDELDFDVVIKVINKRLCSVHDYEAVLQLPLIVLEALVLLLGDGSSSSPSDKGSIDGNESATAAEVSLQVSLAIDLLLHIGKSLEDGQAQRRPFDVNRSSTENQQRCRIRLGVLKGLSAYPLYFLGLDDSGMKSFLESKEDPKGRSSILQSGFRYKLLVDIVIGGVADTSLEKQCQGPNPAVCLARKIVNFEDNTLGSALWLKEGRRSSKVTKRHSKTLFAILPTSESMDTLLSGNTSGAAVAISRLICADGSQLSILRDNADACIEGSDPLFLSLALQGYLHVAATLVSFRRPEIGDILEEIGSWYEAFVSPDAMYLSLAALSVYILADMHEQSSKSIPYAEEIYDLVLKAFKEKRFHKDSISKLAVSLIGVNCIRRGSSESLDQVILVLEHSIRGYGGQQDFGAYYGLALISQALSTFTTPIQLDGVRSRICRTVGFLMEDLLACFDDAHAFFRDIVACIKSGSYTTDLLDTILDVDRNSISVLMTKHVVARYLFFSLAHCLPALKLIDGKIFIVVLHAIETLERGGGKGIVLPAIAQSCQATDLLELDKLKPLSTQKTAAFDSRMSSDAADIASDGLGDIFYAVNGKSNRPTLHVVRQLLAGNIELFDDNACVLSLIAVVSKVCLLPFLGTSPFVLSPKLRENVSQSDLESIVDLVSQAAQSESDSKSSRMALVMMSILSCLMNADELSAATALSQKSEETQAQMPPTRSSKQGLAINFSKLPCPKSGTALDGIMDVLENASIDPMNSVNSFCASVAVLQSLSLPEQFAKSFIEPLLQEESCAIKTSLIDLLLSQIQGRRKVTFDGRDFVTLALRLCLAPEKEKKNQFGGVPSFQRFVEALPLFAMKLPSSSFEKAINEIWQRCVSVDEMMPSILGSFFTGMKGMLCSTALSPKALNCMRRFVLTKMLAQLGEMDIESVLEVSALSNARVIDGYSSCLIKIPLLTFDNIGFFDYDTADRALSSFQVLRSIAILELVRNNFFEDDRQRLELAKMSVWIAALLPYSRDAVAKAGLRRIMCSFASASSKAKAVARPDPLAALFENLLQMTPDSIVLGLDWLAVSMSSWSGGKASDGEMTLGFLSSTDVHSYNALPPADLDRLFAVFLDDLPFNLGLFCRQHKTFVIKMGKCWHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7M9</accession>
    <name>B7G7M9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183171.1">
        <property type="nucleotide sequence ID" value="XM_002183135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7M9"/>
    <dbReference type="PaxDb" id="2850-Phatr39038"/>
    <dbReference type="GeneID" id="7194786"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39038"/>
    <dbReference type="HOGENOM" id="CLU_964612_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7M9"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="31455" checksum="5EC20462D3381D6F" modified="2009-02-10" version="1">MSAVVATTKSYTHVVSADGRTMTVRLHAAQSSRDCFSADQPSTGHAVWFAAENLTQMLVDQVRSPSKSWREARHVLELGAGPGLVGIWAAKLLEDGGSGARDNGNLTPGTETRQYLFTDGDADVVALLQRNCDYNAMPDSVVCAKLWWGPEESSALRSLRPGGFDIILGADLIYGREHTLQQGNVLDNLMSTVQTLLAINGVFYLAFTRRDLPVDVVLACAEKHGMVYELEEDYVFDIFDTNTDGQTCFWRDAIYAFRRTRIAASPLLPAAATPDGAVDRGCGHDGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7N8</accession>
    <name>B7G7N8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183048.1">
        <property type="nucleotide sequence ID" value="XM_002183012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7N8"/>
    <dbReference type="PaxDb" id="2850-Phatr48558"/>
    <dbReference type="GeneID" id="7194727"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48558"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638536_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7N8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="468" mass="51754" checksum="4D764DE08C167090" modified="2009-02-10" version="1">MDNRPAPLMISDDEVSFSGNAKVSKTANCATKSYGGYIDYAKISFDQVSQSIRSPVAMRRGPRGGVTVPFPAKLASLLEEVSLEGMEDIVSWGAHGRCFSIHKPSQFVSELLPRFFRQSKLTSFQRQLNLYGFGRLTRGRDRGSYYHELFLRGRADLCKIMLQTRVIRDAAQRCLEPIAAVAPNFYAMPTTEGGDKDQLFSIQNTWKGLYSRQKTAATLINEDLPEEFDLVKPLPFAELPPAPSTSAASSPDVCVVKARNSTAQSLASESESSVRAARKCSQPRGHPLACPPKLKLCVGNIISPIIDGPVVAPPNDLCVLVDEPSSVPFFFEDMPFTPVAHNVVTFCRTDSRGTASCSNGRTAEELSIDVNVDEFGSSLFEECFASYSIHLFLYTFLTGLRNATKFSLHIVSLTLPRYFMDRLLWPKRLASEPVAFNAGLNQQERKANYKRFALKALVKFNSTVSGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7T0</accession>
    <name>B7G7T0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183199.1">
        <property type="nucleotide sequence ID" value="XM_002183163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7T0"/>
    <dbReference type="PaxDb" id="2850-Phatr48590"/>
    <dbReference type="GeneID" id="7194809"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48590"/>
    <dbReference type="eggNOG" id="ENOG502S5TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084066_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7T0"/>
    <dbReference type="OMA" id="HAGKGIM"/>
    <dbReference type="OrthoDB" id="533393at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36974:SF1">
        <property type="entry name" value="DOXX FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36974">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855920" evidence="3">
        <location>
            <begin position="32"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="31323" checksum="37273E69F6762C0D" modified="2009-02-10" version="1">MALHSIYARGFAFALILLLCGASKTIRLAQAWVIPQIHVRYTFDRSPRFHPSRSLDYPPVSDPATRLRAGNSNNNDGSDDDRDSAPIIVERPDPSVLVAARDDDSQKLAIAAVGGVLTVGTLAVVQVLNTMEAILPNGWFALWRDYTWPVPMGAIFVAAGVAHFALKDTFIAMVPPQGVWGGLWQVPAPGADEWNLSYAEYHVYWTGVAELGGGLLLLTSGLGLTPLPVQIPAALLFALTLVVTPANTYMYTHDIQAPKLPPIPYPEGHYGRAALQCVLLAIFWKLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Z1</accession>
    <name>B7G7Z1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183102.1">
        <property type="nucleotide sequence ID" value="XM_002183066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Z1"/>
    <dbReference type="PaxDb" id="2850-Phatr48643"/>
    <dbReference type="GeneID" id="7194841"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48643"/>
    <dbReference type="eggNOG" id="KOG2501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019626_2_0_1"/>
    <dbReference type="InParanoid" id="B7G7Z1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="159"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="415" mass="46184" checksum="4AF66A6377358963" modified="2009-02-10" version="1">MAGNDGLIKSFGEGCQLWSATLQQTQPASDVISDKVVLLYFSAHWCGPCRRFTPALASLYKSLKARNEDFEVVFCSMDRTAAEYRSYTDEMPWWSLPHKSPALGKLANLYGAVGIPHLVVLEKDGSVLHSDGIGEVSVDPEGKNFPWRPKKLVELLPASYIGQDKSEHSISDLNDKYLMLYFSAHWCPPCKQFTPKLSQAYTALKEHRDNFELLFVSSDHDQSSFDEYFAEMTFGAIPFAAREAKAAISSKLQVRGIPTLMIFGPCPADGGDRPLINGYIRGVIEQGDYISEFPYVPKAYGDLNKTTDNINNYKCVIVFHEAGDDEEHGEIQEALKGASDAYVGRGELKFYWAFAITGLSKTVREALEIGPIGDAPVMIVLDIPNQGSFYVSEAPEITTTNILRFVQYPGERKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G851</accession>
    <name>B7G851_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_48718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183414.1">
        <property type="nucleotide sequence ID" value="XM_002183378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G851"/>
    <dbReference type="PaxDb" id="2850-Phatr48718"/>
    <dbReference type="GeneID" id="7194991"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48718"/>
    <dbReference type="HOGENOM" id="CLU_039704_0_0_1"/>
    <dbReference type="InParanoid" id="B7G851"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053166">
        <property type="entry name" value="UPF0718_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42775">
        <property type="entry name" value="PERMEASE RV2963-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42775:SF1">
        <property type="entry name" value="PERMEASE RV2963-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49661" checksum="731EEDF953CA3680" modified="2009-02-10" version="1">MAAFLESWHEAAITSLGLFWTAFWAFALGYLISSMIQVFVTRKKMQELMGVEGVKSIALATFFGFVSSSCSFAALSGARSLFAKGAGLVPALSFLLASTNLVIELGIVIAVFLSWEFVVGEYVGGIILILLTWLLVHFTTRFAPVEEARQRALKHENAGSEGQGSHGNQRRRNEGESMKDGASRDKRNSDTEREVEDGDASDDDDHESRDEDNQGSMKPHKFFAKDSWEQVAMRYFMEWNMVWKDVTVGFTVAGIVSAFVPNSFFNWLFISGDDPSFWELLEECLVGPVAAFFTFIGSMGNIPLAAVLFENGVSFAGIMAFIFSDLVVIPIIRINAKYYGLKMALYILGVFLTVLVATALILYYVFDVIGILPSPESVDSLSERDFFELNYTFGLNIIFLVMSVGLFGWYFAKHGFGWSMGGTVIEIGLFWLALASYIWLIGGLLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G865</accession>
    <name>B7G865_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anti-silencing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_52450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183287.1">
        <property type="nucleotide sequence ID" value="XM_002183251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G865"/>
    <dbReference type="FunCoup" id="B7G865">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G865"/>
    <dbReference type="PaxDb" id="2850-Phatr52450"/>
    <dbReference type="GeneID" id="7195018"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52450"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060354_1_1_1"/>
    <dbReference type="InParanoid" id="B7G865"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17553" checksum="E7D3C178EB5C4322" modified="2009-02-10" version="1" fragment="single">NTQVVLDNPTCFLNPFQFEITFECLQELEDDLEWKVLYVGSAHDSHQDQVLDEILVGPVPVGRNKFVLQADAPDSQTLPKDELLGVTVVLVTCRYKDREFVRVGYYVNNEYTKPGYDPDADGPVSWPFALEHVTRHILADKPRVTKFAIPWDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G940</accession>
    <name>B7G940_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002183667.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr48985"/>
    <dbReference type="GeneID" id="7195257"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48985"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231236_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2198" mass="243340" checksum="7618C400E5023999" modified="2009-02-10" version="1">MSKPRPIHTLHREIRTSPDESEPAFSYEEQRTGFLHREDEVAEDFHQRYAVHSKSRRDSGGGNSNASAGGNGTSTGGGSFWRTSEAGSTGPAFASVHMNSGKDQYTSNSARKSTGVLGAALESHDSTDSVERGQSDSSHATPTAATGTALHSLWNGGPNSLHGTTPHEILRRKESSMSVCSNASWETITTSTTTKPVLAKKKKEKLVDKQRAADRRQKWDSQSAIIDASIATGPASAGGGQNGDSNSATTIMTTPKVVVVAPPNFSEMTHGSSLERSSSDQSTGSLLYGKTPHSGSLLGKSSSLIFPTGVDANAEADSEADNLKRRKINLLLDQCESVRFPFNKKKLVLNNMSLTAADLPLQYLVGTSLGNTLHKLSLTGNRLGSVPAKLVQHLPFLKHLDISQCELHQLPDKWNLPQLKRLNVSHNRLRDFPEEGILEGLPELQELNMYGNKVAEIIIHHNTTVLSKLEILNLGYNDLAYLPDDLDQLKALKTLKVMNNFLEKVPMRVCEMELKLIDVSSNPVIQPPQETCDRGICSMRRYYHCLRMEEQSKQRALEEVQKKAQKGKKAVPKKKCYGGFMKSLTKPSRKNTDDSAMANSVGPVQSGAHLDDGHYVNEQGAFALKVAPMERDTSSVDLGKERSLQQRLTSESSEEVVESVAASSPVVDAYDQVTVNDTLKVIFVGMAMVGKTSMIKRLIGGEAASVPTHDQRTVGVDIYQWNPKEDVRFEHIDSRIEFQDEELSAACGDVDVKFSVWDFAGQHVYHATHELFFSSRALYVLVWDMGAMNRDTMKRKGSLLEDSETGAFKLSYDSSDDESVGDCDDDNFAVEEEARRADRALERDIDEKVQFWVDCIQSSSPGAAILPVSSFADYFAGDDCEGEAKRRCNMLKNRLLKHERRRIKGIKKRLKDYVDQNRADDPAALRLRKLLCPYTRPKLIFGNDEDSVVRVSGTQYTGFDRLTSKIIDIASGRDKGQWRYPIFHGHVGARIPRMRLEVREAVTHMRSKFMVVEWGYFINQLRDRGLTSVEDISDALHFLTNIGELSYFGGVMTTKDQVANPIKKKSDKGSENDQGEKGSMARERCDGNDSDVDDTDPDTAVLSMDDTSITAQSTADGSLSTVDDFMSSSLSQFVFLNPRWLVTAVACILRHDLDREIKETRRMTSIGQGRRLARDTSFYDAQMNCPVITAEDACLLWQTKGITKRAAERAQKYSNNMTVTPFEFLQLLLIRFGVFVPIDLSIDKAFLGGHEYAQLVDSLCGHAPTPEEVEIIVDSDEVAPKAEFFFLPSLLGSSEPAEAWTYKNTDSWKTTLCHSILFPDGVPPGLMERLTAGVLSSIYAVAHRKNVSGQDFLGNDIATYEGKLTVKEVLCWRTAFLLKLGTQVTAGDGSSKESIVEIIALLADRDSHLCVGSAYMGIGMRRLIVSGRGQVGDGGRKIWKGGYLLVLKCVRRVMDQYGGLEYEKQAFCPECLAKKGVSEASSWEFNSIRSSVLNGEGNIRCQHGHRVDTPLVAGPIDVFPKAKQEAFTQPSESGLDSSVPVQDLLRAIVVVGLWDGKERKIIRVGSGFIVDRKHGLIVTASHTLMNIWGDKNTPFGENYYGLRQGKVVIGVIPREKEGGDAGNKDMAVFRYFATIVAKDPSMERGECHLDACVLRITTRMEQDVGGYGDGCGDQPERLLLNNPVAMKKEKLQALKITDKCELEEQVRILGYNQGGEGRLLPGESLNRYVDFARGYVCKRFASGEESGNKVRDLFKPRQEIVVICPTIGGHSGGPCVNQQGEVIGILSRADPAENQRCYISPTSEWVALSHQTRHQLVFGVFSLSLLRTTHDDDMTVNQNHTLPDHTVSMNACQNNMITLTKRTLPQAIHRQTQRRALNILSRIVTSNAEQQRDLDSAIKTVRLHDPAGYLPGLLLPERRMQKAYYAVRGFWIESGLRFGNSAKISKHSSPEEQLKWWKQGVDAVFAGDVLTVNQNHHPTLRLLQSLSTEVPWTKQHFDDIIDGRAKDLNVKQYETVADLTRHAEQSCGTLAELVLESGEIMPDISPACHEAARLVGIAHGVTNALRLSIPVISTTGKLIIPTELTTKYGVRSPRYLLSALGQGDKVCLRAMENAVRDIVETARDNLQKARDLREAILAEPNGNKAVSVLLPGLASETFLNRLEKSQYQLTDRNLRNVGSLEHAVCASRMTLAYFQKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9E5</accession>
    <name>B7G9E5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183763.1">
        <property type="nucleotide sequence ID" value="XM_002183727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9E5"/>
    <dbReference type="PaxDb" id="2850-Phatr49075"/>
    <dbReference type="GeneID" id="7195432"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49075"/>
    <dbReference type="eggNOG" id="ENOG502S115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115186_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9E5"/>
    <dbReference type="OrthoDB" id="446939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36018">
        <property type="entry name" value="OS09G0481800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36018:SF1">
        <property type="entry name" value="OS09G0481800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="203" mass="22332" checksum="3173E1708CCB9628" modified="2009-02-10" version="1">MVTASFAIACIAMVTITLNDWIRVYAYTSVRMGGTPFSRSTKPQALLMSSEWSSFQALDDDDDDLMGKIDTNEYAIEDDSQERKAEIGSSLKAPTIDRSADPIQVPAELTEETVLGVLSACRGELGTLFGYSAENRGVGITGGVDYVDLDGPSVILSLKGRFWHQRTAVLERVGNYLQQRIPEIVDVQVEDPWQLTDAANEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Z4</accession>
    <name>B7G9Z4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183977.1">
        <property type="nucleotide sequence ID" value="XM_002183941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Z4"/>
    <dbReference type="STRING" id="556484.B7G9Z4"/>
    <dbReference type="PaxDb" id="2850-Phatr39918"/>
    <dbReference type="GeneID" id="7195706"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39918"/>
    <dbReference type="eggNOG" id="ENOG502QTTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664758_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Z4"/>
    <dbReference type="OrthoDB" id="41771at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="30182" checksum="A925B832D03E8159" modified="2009-02-10" version="1">MEKLSSSPRIVDMYGYCASSIVAEAMPTDITTQLVPGDKDQYDRGRMKQKDLDKLQTTDVYPLNNFTAIEKLSLALTMAESLADLHGFEGGVIVHGDYHPDQHLLSDKGQLKLNDFNNGEFLHWNDVDERYCYYSRQFGGTYKAPEEFSGGYCNQEVDTWSFGNNIYGLLTGLYPMYETYSHSEVRERFLNHELPYVDPRYRSRSYIEGRLVEIMEKCWAYEPEDRASIFDVVIFLQETLRKHEAEQRELLKKHGAHQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA43</accession>
    <name>B7GA43_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184003.1">
        <property type="nucleotide sequence ID" value="XM_002183967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA43"/>
    <dbReference type="STRING" id="556484.B7GA43"/>
    <dbReference type="PaxDb" id="2850-Phatr49291"/>
    <dbReference type="GeneID" id="7195467"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49291"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513379_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA43"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="231"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="60856" checksum="9D1F8BA6EB09C68C" modified="2009-02-10" version="1">MRRPLRLWYKEPPPPSHDPPSPQLHHHHHSRFYHPHWGFLLILSGVALQMWVSVTQLSALEVPENNLDVPLLPAFRSTREDSSRKTPASTSAWRLYVGRVRYGVPVSAASYTWEAQPPRVVRLAHDGSYQHPIPSSRNRVARRNVAELGNASCTYCQYESDQHLWDFEKPFYEDCTPMAKWQTIFYPTCNVLHEITMMHSEEDYDPKGHDLADESIDEIEDNDDDTVPSIEETTLLSMQGSWRSVWKYQDAVNDTAVLKVLKHSREFDHESFAYHITDAIVMERLTSSPHIINAYGFCGQSVLTEFASGSARKLIKDPKFNSKERLKMGRDLARALTAMHSIDFPNSTNPTLAHNDINIANAVEVDGRIKLNDFNLAVLMRWNDTQPCGYPVRFDRPMWESPEDVRNLTYVDPALGDVYSLGNLLFSVLTTRQPWLHLEPNGPYNKTEVAQMKTQGIMPAIPDKYLESRKMAHHALYFAIQAAYRDDPAERLSSHELAEALGIALNWGRDGRRTSRTDLAMLFVKPRPDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP9</accession>
    <name>B7GAP9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CrcB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184114.1">
        <property type="nucleotide sequence ID" value="XM_002184078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP9"/>
    <dbReference type="STRING" id="556484.B7GAP9"/>
    <dbReference type="PaxDb" id="2850-Phatr49471"/>
    <dbReference type="GeneID" id="7195823"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49471"/>
    <dbReference type="eggNOG" id="ENOG502T75V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535851_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAP9"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="53250" checksum="1DD38DF20FD20415" modified="2009-02-10" version="1">MTDWQSLDQSSLNVRVDPSTASSPSTDLLASKNDGLATKASSSSKMDAGKPPTAVAAGGSGAANETVGCEFSMERNPPWNGGQPAVEDSNGKIIDALQEDVGDSTFSPSPQLSKGNRGQHVLYISTFAVFGTVIRVFTGRLFGGDCGNTASTSTSVVADFVEPWASLVCVTANGKTDQTGGALFTDLPANMLGSFLIGVLSLMGTHRNRTNHPLPWFRADHPLQRHTAFHVALVTGLCGCLTTFASWNTQMVVMLDGTDTVLGSQPVPALFGYLIGISTAATSFLSGRHCNMLLRSRHRESLSSTRNDIPAVDTELGQPVLERPPPPSSRAPVQPCWLTRLLGIRVAPFLVVTVLIGAFVVGDVVYQVPFYRKMWISIALTPLGALLRWRLSRWNSKIVWNRLAWVPWGTLVANLLAAVLSAAAEAIGERYYKNDAWTFTIWKGVGAGFAGSLSTVSTMVKEMFAMDSPARAYFYATVTVIAAALLSLAVYSPIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAY8</accession>
    <name>B7GAY8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184275.1">
        <property type="nucleotide sequence ID" value="XM_002184239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAY8"/>
    <dbReference type="PaxDb" id="2850-Phatr49542"/>
    <dbReference type="GeneID" id="7195752"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49542"/>
    <dbReference type="eggNOG" id="ENOG502SSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710727_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAY8"/>
    <dbReference type="OrthoDB" id="39124at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="389" mass="43039" checksum="BAF4FAF784313D2A" modified="2009-02-10" version="1">MKSATRRQQRPSHKRTPSSNSSLPSNSDRSAASALGLDGGQVDMPDSALLQFDRDAFSVSWKELVWTACFIGVVAVLSAFVGASAGISISIHFMETAQTPSFSRIAARERSMGPHLRVTMVDPKMSFSNIASRKNPHSADGIGLERVVTKSPTGWHSVLMVVDEQSLNDTEINGRWNKKAAMKLSPYELDWKPQVRPKMCSDGRTAGFDSWSTLRDAVQEANTYSARRFLHWTEYFAWMDDDFDGVFEDDSLYFEPEIRLAICPKAKLTPPKKHYYYGPRNEPIYVNAENIVLECDDCTMDAAGGTGHFLFGPQAKNALIRGVTFRRAKGSSISFYGDGAEVSFEDCLWVGQKGAASDRASISDVNSVVTLNFLRCEMDGINLIPLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBM6</accession>
    <name>B7GBM6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184553.1">
        <property type="nucleotide sequence ID" value="XM_002184517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBM6"/>
    <dbReference type="PaxDb" id="2850-Phatr49709"/>
    <dbReference type="GeneID" id="7198411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49709"/>
    <dbReference type="eggNOG" id="ENOG502S7VU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835397_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBM6"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37989" checksum="6B920FF822D3DD0A" modified="2009-02-10" version="1">MNEERSALRIETLSKWWKDRDENGNCRLPLLDLRSNAESEESHLRLSRKSPVNANIVHIPLDEISRRNYELPPRSLEFVVLVPGEYCLSTVSKLLLGKTPSRKDKSNLRKRQPWMVQYAILASDLSSRDIEAWMSLACKQTYCSGRQDVRAISFVPRPRLWQPDPMVESLLLPVLQSELTQRVISDPSSHCEIWDLGAGSGRDVCFLAEQLLARLTCPNFTVVGYDQRYRNLNTEPCRAFYNRRGLSHVTDSRKIDLTNVNEVVAELDRVVTNSNRIVIGLFAVRFWHRPLVEAIAASTSSMSSASVFAISQFGRAFDGASWDFEHPKVNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCE5</accession>
    <name>B7GCE5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_40783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184794.1">
        <property type="nucleotide sequence ID" value="XM_002184758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCE5"/>
    <dbReference type="STRING" id="556484.B7GCE5"/>
    <dbReference type="PaxDb" id="2850-Phatr40783"/>
    <dbReference type="GeneID" id="7198640"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40783"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414191_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCE5"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777">
        <property type="entry name" value="HEMOLYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777:SF17">
        <property type="entry name" value="UPF0053 PROTEIN SLL0260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="403"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="663" mass="72514" checksum="4ECFCCA4EFD2D005" modified="2009-02-10" version="1">MAVASGGSMGIKKGPVIPLERKELISLGSLWFGLFVILALLHAAEIAITTLYPWKVREIAEEEEKQGNMRGTFKVLNEDITRVLTTILVASTACSIFATTLFTHLVASLFGLQGERYGAIALTGLTLFFVELLPKSLGVTNAETVARIMVPPVNVASAIVSPLGISLSWLAKRTLSMLGVKDKNSGSGVSDSQLRLIVTGALDSGTIDHGEQEMIQGVLKLQDQRVKEIMRPRVEMVAVPVDMSVASVLGVVRESGYSRIPVYDGEIDNIVGIVLAKSVLDFFVNGVLVDEDLSKKLGKNTEEIKAAVEDLKAADEARRGELPDDIQADADKVMERVDLKIDALVDQRIDANIDASLPPSLYTPERIPIRSKGNSNEPQGYVRSLTATELASRMEKSIQEAGLIESCYFVPDTANGWSVLQEMRRRRVHLAIVVDEFGGTGGLVSLEDIVEEVVGEIYDEDDDEDFQVSEDSIAMQDDGTFLIRGDADLEDCDTILELNLDEEEALKEFSTLSGFLCMCAGEIPSVGDFIMSRGWSFEILSADDKKVLLVKVERLVGAFDNEEEAASENVLKNLLKLNSNKEHNSNHNSNDGDSDSENRDGRDSEQDREQQAEGELQSTVAANMAEAREIERMVEAGERKRAVLEAIKFASLANNTSPDRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCV4</accession>
    <name>B7GCV4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_16499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184867.1">
        <property type="nucleotide sequence ID" value="XM_002184831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCV4"/>
    <dbReference type="SMR" id="B7GCV4"/>
    <dbReference type="STRING" id="556484.B7GCV4"/>
    <dbReference type="PaxDb" id="2850-Phatr16499"/>
    <dbReference type="GeneID" id="7198760"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16499"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_0_1"/>
    <dbReference type="InParanoid" id="B7GCV4"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="40"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="378" mass="41766" checksum="691ECC710FB49466" modified="2009-02-10" version="1">MDDSGQTYTYLNYPLENGQVLAEAQLRYQTYGQLNETRDNVMVVCHALTGNASLHAWWGDMLGPGKVFDTDKYLVVCCNILGSCYGSTSPVSIRPGTDQPYGLDFPDVSVKDTVRLQLCMLRDELKVASVHAVVGGSFGGMQAVEFAVQAGSTRAAFTDAHGQPFCKHVVPIACGAQHSAWQIAISEVQRQAIYQDPAWPTDPFRATHGLRVARQLGMISYRTPQGYGSKFGRERQRGRGDDDTDGPAYGSHARWQVKSYLEYQGVKFLQRFDPVTYVKLTEQMDSHDVTRQPAGSCPGTVSKEQVLGHVTIPVLVLGIDSDVLYPLAEQQELARLLPNATLEVIHSDDGHDGFLLEQEQVAAHIQHFLTLHERPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD26</accession>
    <name>B7GD26_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_50133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185059.1">
        <property type="nucleotide sequence ID" value="XM_002185023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD26"/>
    <dbReference type="STRING" id="556484.B7GD26"/>
    <dbReference type="PaxDb" id="2850-Phatr50133"/>
    <dbReference type="GeneID" id="7198931"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50133"/>
    <dbReference type="eggNOG" id="ENOG502RY20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435128_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD26"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="629" mass="68905" checksum="296D20B4C9E74716" modified="2009-02-10" version="1">MMSLTTHLTTSCSSFTFENDADALFANTTGTLFTVGIAWCAIAATYVTIIVRILRSDRLSSWRELWKVPASLPLCIASFSHAACPRRRSRWFKCTQRGRSSLSGMALCEMSCPLQRAAAFYKLHLPPPLPWTCRRRANRLRQEQEQQAAIAKVLPEPSPSDQDSSVSSRESLVSHTSVECAQAETSTTTLTTTTSTITTSSSTSHTTPSPRTSHRPPSRTRIPVSSLLDMARMQQWQTIVAAAPLHRRDAKQRDADGLYPLHWACSGGPTLSVVQTLLDAYPSAARKRDTEGSTPLHFASCYSASTAIHQTLLGVYPQAASLPDRYGRLPLYHAVEHNAGKAVLEALVHVDAASVTQPCLPPHPLHPVPLVNGNRVWATRTPLFVAWANLDRPAKLSFRGKRWDKAQYLLRTAYQHHGHPGTGTGYNFIRAVIAMDLYLPEPILDMAIQARPELLRERDETGSYVLHQAAATLTHSPQRARDVLHSVLDAFPAAARVRDNYGRSPLAIALASGKVWKDSAVQALWQAAPEALAWRDGKTGLPPVLVAATAMAPLWTGTEESSFAALGNDPCGLLTGKQQELLRRRSLSSAETNRAKHQYGTGDPDVDALETVYSLLQADPSVLVTATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD87</accession>
    <name>B7GD87_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_41082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185086.1">
        <property type="nucleotide sequence ID" value="XM_002185050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD87"/>
    <dbReference type="PaxDb" id="2850-Phatr41082"/>
    <dbReference type="GeneID" id="7198873"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41082"/>
    <dbReference type="HOGENOM" id="CLU_2282921_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD87"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="10746" checksum="1D449D333C73F5DE" modified="2009-02-10" version="1">MAYEDVEADSEYWYPTHNSLLTKIRVWVSVKGYGNSDGASKGILGGLSDGNDKGCKDGEANGIPNAFNNGAIEGFDDSVADVALEGTPDDKALELPGGDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDY7</accession>
    <name>B7GDY7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_50388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185291.1">
        <property type="nucleotide sequence ID" value="XM_002185255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDY7"/>
    <dbReference type="PaxDb" id="2850-Phatr50388"/>
    <dbReference type="GeneID" id="7199202"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50388"/>
    <dbReference type="eggNOG" id="ENOG502SZ2D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784065_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDY7"/>
    <dbReference type="OrthoDB" id="47421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="354" mass="38616" checksum="33C23ABFCA90EC84" modified="2009-02-10" version="1">MSSASDPQGWVTNPPSVLVKVRDITAKPHLNGELGVVVGYLPDRTRYVVVTCRQQEQLSLKPENLHKANFLEQAKGQYQLLTNDPRVRRQLQQVYHRVQTKLPAPLQPEHVAVVLLLLILASGYFLGVSKTLMIVSLLLGLATLAGPEIAAGKSWEQIGRDLPRRATSTLQDTIRQSVPYVGPKLADTPYVVPALLGILLAGTVKVLLLPAQPRVPLETAATALRTEPGAPRRGGALPDAEELYKLGFDDATSNLAFGTSLSPPSVVPDDFLVNDDYSDMPSLTTNTRVSPWNWSTLMSVFYLGRTVYALGWDPVQGAWSWGRAKANLVTQPTYQSAFLALSVYRVVSAIAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEH7</accession>
    <name>B7GEH7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_17048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185525.1">
        <property type="nucleotide sequence ID" value="XM_002185489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEH7"/>
    <dbReference type="STRING" id="556484.B7GEH7"/>
    <dbReference type="PaxDb" id="2850-Phatr17048"/>
    <dbReference type="GeneID" id="7199354"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17048"/>
    <dbReference type="eggNOG" id="ENOG502SCDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1345500_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEH7"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="67" mass="8108" checksum="87C12C01621CA04A" modified="2009-02-10" version="1" fragment="single">RLLKEVNYYQKEVQENEVKLQQMKDDNRDPYDVKKFAEVLDESYMMVPDSEARLAQAVHELRDFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEN8</accession>
    <name>B7GEN8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_41608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185561.1">
        <property type="nucleotide sequence ID" value="XM_002185525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEN8"/>
    <dbReference type="STRING" id="556484.B7GEN8"/>
    <dbReference type="PaxDb" id="2850-Phatr41608"/>
    <dbReference type="GeneID" id="7199427"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41608"/>
    <dbReference type="eggNOG" id="ENOG502S4D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102256_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEN8"/>
    <dbReference type="OMA" id="CTPQSCA"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF21">
        <property type="entry name" value="BCPB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="200" mass="22340" checksum="3EFED3E29F9B08EC" modified="2009-02-10" version="1">MVPHGSASQNDWSVVDWSRIPPPVDDGGTDHLQPGLVLPSLPQGTHLVSTDGARIDPSRLPGRTVLYAFPITGRPDQDLPRGWDMIPGARGCTPQSCAFRDHFRELQTLRVQHIFGVSTQTPEYQTKAVARLHLPFSLLSDQDLVCANLWKLPTVQVEGRTLLQRVTLIIDDGVVKAKFYPIFPPNQNALRVIQWLTHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEP4</accession>
    <name>B7GEP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185564.1">
        <property type="nucleotide sequence ID" value="XM_002185528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEP4"/>
    <dbReference type="PaxDb" id="2850-Phatr50614"/>
    <dbReference type="GeneID" id="7199448"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50614"/>
    <dbReference type="eggNOG" id="ENOG502SDA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246814_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEP4"/>
    <dbReference type="OrthoDB" id="2276795at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1123" mass="127285" checksum="BA699B8375652E8B" modified="2009-02-10" version="1">MPDVEQHRRQSSNAELSWSEISQLTDENWQYISEDSRSGIVEISRAGNLTFSSLDLYGREKEISTLKEAFDRSRSSRELLLISGQSGSGKSALASCVEQPVRQAKGFYLKGKFDLNQQSQPFSAIVSACSRLCEELLQQEEGLSCPGREQNSGSREERSSKQWQSVFSLDEIRTRMHEEMANEVEDLIFVVPGLADVVGIDVIQPLNDSTKDDPLEARNRLNAAFRKFIRVLGCFGPIAMFLDDMQWADLASLELIEFLFTDPEKTGLLILGCYRDTGLDDTNGYQKLLRKLKRRDETTITEIEVRNLSVRYVNEILSDLLRTEKGRTLPLAELVHRKTHGNAFFAIQFIKSLVDSRILKPSDSSAWAWDLEQAEKSTEPTSNVIDLMKSKLKKLPYDVCLTLQLMACLGSTFTFRVFHLIVDEFYNNPLHVDPTKLAVQPLDQRKPEECLQLCVEQGLIVAHRRHSYRWIHDKLQEAALSLLPSDSLPIVQFRIGNLLRQNLSSVEIESSVFVVAALLNEGSEALLTDEQRIQIAHIDLVAGKKAIESSAFVSAKYYLEKGVELLPVGSWNEHYRLTLNIYSTAAEAEYCNGNAVMVERYCDEVLKQIHRPLLDRLPAYKVLIETTGAQGDHKKAAHLTLDVLSQLGCPFPKYAVLIQAYAGLQKARLFQRRLSTEKVNGMRQMTDIKDIWIMSLLDKMFAFAYVGRLPNILLMSILKSLQWTLKKGLSDFAPSTFARVGLVFAAFLNDPKTSEMYAEHCMSLLVRTSSRKAKVKASMIVQSFVFHYLRPLSSTTRPLTHSYELGMKIGAIDDAMWCFFFAQETKVHCGVSLNSIADELSVAIKQMQDLKQVKQEELCYILERVVLDMTGNARDAHLLSAKYLAQDELFARLRQTEDTTMKMYFLRNRMAVAFLFERYDLLMELLEDTGYQKFIEKAQPGVFAVQSMTFRNALACVSVFHRTGDRHYLRLANRLAWKVKKAAKQNNPNLFHYDALLDAEFAATNGKHAAALKHFGAAILLAGSRRFQNDQALIYERFGEYNDREGQKDDARYSLRLAIESYQVWGARGKANQIRLKHAGLLTPPAEIEVGDFNPDFLTLRHKSLDTAHVRGTAQVEKPLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Z7</accession>
    <name>B7S3Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_bd1642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176310.1">
        <property type="nucleotide sequence ID" value="XM_002176274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Z7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1642"/>
    <dbReference type="GeneID" id="7204879"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1642"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500108_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3Z7"/>
    <dbReference type="OrthoDB" id="48357at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="439"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="584" mass="66199" checksum="1013C5302B0D3CA7" modified="2009-02-10" version="1">MQICSKRRIDCWCGRPFMPFASKRQAGYLTFSFVVLFPFARSFLLTQPKVHVAMQTESTATTDCDLSFSKSDQPAPLYITIGPPCAGKTTWLQQQQRHSPDYSQVSIDDVSLDDQPDTYVPLNTEYFLTNTANSYPEELRTHCICGKSLAERIQGNDQRELRTVLQRVAGNLTESEFRNAIIGNIVGMDHCESTTSKSVQTLLVNAVERCMQDQTMVALLPQTVDLFVRERIFRRDGTHSTTGLESSEKALYACPIDRPVAWGNTNTRPSDYRMALVMAASTRRPVRFVVYSDKKALLRILNNSEMDLADKVPQELFGLQATLPELIDRNVNRLLTSGRYVPVSVIRDMHERSLELLQKVVHGWNSLSRNHSNNSKLTAFDLDRGLARLVDFDLLADRTVVDLRTAVGNEAVLIHGLVVNRQSPYGMAQLIPEEHGWTRHLPDLLTEKSVDREVKRAFSTWRKTEGFMPTFDFYVWMGTGGTCTPLHFDSYDNLFMQLVGAKYVRLYPRDATLKLYVSTSGAYGLQGIMNDLDCEREDWAVHGKARDAEYTEVLLLPGDALLISARTWQYVRALSTSLSVNNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7S447</accession>
    <name>B7S447_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_bd1682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176337.1">
        <property type="nucleotide sequence ID" value="XM_002176301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S447"/>
    <dbReference type="FunCoup" id="B7S447">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7S447"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1682"/>
    <dbReference type="GeneID" id="7204864"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1682"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_2_1"/>
    <dbReference type="InParanoid" id="B7S447"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="13">
        <location>
            <begin position="350"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="597"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="927" mass="104067" checksum="F58BE358FAA196D9" modified="2009-02-10" version="1">MSSIFTSVAEDDHQYHRKSEGKPKLDTSSQHKTKEDKLDLRLLLIDHYDSFTYNLVDLLAQICVHPPIVVAADVATSWEGLEKHLQLLLSTTSEDTPFQNYQQGELTSLVDLLDGIVLSPGPGRPDQAPLSLDIVRKAPSNLPILGVCLGHQILGHVYGANVTLAPNPIHGQVQAIRRVNGEENDEDPLWKNIPHFINVTRYHSLQVLLDYNKESPLLIPTALAENDNVVMGLRHHLLPHFGVQFHPESIGSSTWGPELLRNFCNLCVARQDSNTTTTQATRQMTWNTSGILDSQENTVSPLPVLKELIQATISTRTGSIHTTTRSPPRVFLHRIEYTEMEPEILMQTYLVNEPYNFWLDSANAETNKSSSQQTMYSILGAAKTRVEYYGKEKNDRRGIYVFEEEALKLHLPDTDVLTYLEQYHNPRRLTEGATILSFEKKCADERGCITKLFVPETELSQQVGFGFRGGHVGYLGYETRHDTTSYLEAYEGGGTAPTRKEKSRLSSSTDPHVPTAAFLWADRSYVYNHRNREWYLVGVAETSDDESAVLVWMKRTSQLLRRSFKKPLSSDSRLYQQLGNLKYTRPVMCKPNRSRGKYDRNFDSCIEYIRQGDSYELCLTNQLEADVPKQNPFELYQILRRHNPAPYSAYFHWNIGNQGNTNTPSAFAICCSSPERFVSVKPDGIVPVVNKNNKRLVEAKPIKGTCARVIPAQYGQWTEQEKRDDLMRVEALRSSLKDRAENLMIVDLLRNDLSRVCETGSVHVAKLMEIESYASVHQMVSTIRGVIDSSTRSCIDVLKSSFPGGSMTGAPKLRTMELLDEIEEGVGRGPYSGCLGYISLNGDMDMNIIIRSAVLTPSSDNVSWKVRVGAGGAITALSERASEYDEMLLKASAVTKAVEVWGRAGPTDSDNPQTVTSTFKNPLQIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7S479</accession>
    <name>B7S479_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase-modifying factor enzyme-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176400.1">
        <property type="nucleotide sequence ID" value="XM_002176364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S479"/>
    <dbReference type="STRING" id="556484.B7S479"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1393"/>
    <dbReference type="GeneID" id="7204979"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1393"/>
    <dbReference type="eggNOG" id="ENOG502QRY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556077_0_0_1"/>
    <dbReference type="InParanoid" id="B7S479"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF19">
        <property type="entry name" value="FORMYLGLYCINE-GENERATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="518" mass="59565" checksum="687AD856EDD5C57D" modified="2009-02-10" version="1">MVWCARTTTTPQRVILCRSHSRVGYNRCLFVGLLLFLNRSWSYGTSSIQTDESLRNDSGDSIDWPNELGANLEPHPDPNDEHYDNMVYVGRHDEEGKRMGFDVDNTVRYIFGTSFDETHRAIEEADLLHAHADGDDTHRNVADRGQVPLDSTRASEYATDQEQHQALFEQRHRKVDRTGPKSFGYVETHPLDGGVVPPKVVAVRPFFMDTTLVTNKEFAKFVKATYYETEAEQFGWSFVLESFAPNAMLDAESDPEASHWIAVNDAYWRRPEGPDSSYKFREHHPVTHVSHRDAAEYCQWVGKRLPGEREWEAAARAAHWGPRNRTPFAWGDDSADWKVASQYANLWGNGTFPWDNKAEDNWRGTSPVKTFPPNVMGFYDMTGNVWEWMRGGKHKSRIVRGASYVDSLDGSFNHAATLGARATLHGTTTTGNVGFRCVKSPKQRTEYHYISHDENVHGQLTIEDQFGHRDTVPQRGWEDQFHRQFMDNDDDEFEEDDERPSIKRKKVTKRRERISTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3T0</accession>
    <name>B5Y3T0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185711.1">
        <property type="nucleotide sequence ID" value="XM_002185675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3T0"/>
    <dbReference type="PaxDb" id="2850-Phatr46792"/>
    <dbReference type="GeneID" id="7204663"/>
    <dbReference type="KEGG" id="pti:PHATR_46792"/>
    <dbReference type="eggNOG" id="ENOG502SNIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_916637_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3T0"/>
    <dbReference type="OMA" id="GSFWRER"/>
    <dbReference type="OrthoDB" id="192213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838763" evidence="1">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="34941" checksum="C4FFBFA6731146EA" modified="2008-11-25" version="1">MKYQTNSALLIFAAVCHVSVDAVRNLRIVSPLQALTIPDPEVKEEITTARRHFLDRFKVGLEAESKARRELAEKKSEQLQADATAPDWAKQAASSVNRIRNADEKHIETAFDNAVAQFDRDRPSKKAAKNSNRYQFVGLINSASSKTPIMWYARKKPTNAKWSVRLVHADQAAIVKDLFNRGKVDIFARYENIGKASDETKGPIVESTYAVRERSWKNLWNTSPKHWITDSSGMYWRERRLRPGMYTDGKTVYESSYRYRDGRNGMHQRSTLDQFLSSKAFDDKGKQRILRRLKEDAPDVVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3T7</accession>
    <name>B5Y3T7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_36840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185714.1">
        <property type="nucleotide sequence ID" value="XM_002185678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3T7"/>
    <dbReference type="PaxDb" id="2850-Phatr36840"/>
    <dbReference type="GeneID" id="7204547"/>
    <dbReference type="KEGG" id="pti:PHATR_36840"/>
    <dbReference type="eggNOG" id="ENOG502SMSR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1130910_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3T7"/>
    <dbReference type="OMA" id="REHAHPF"/>
    <dbReference type="OrthoDB" id="38589at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039987">
        <property type="entry name" value="PGRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31032">
        <property type="entry name" value="PGR5-LIKE PROTEIN 1B, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31032:SF1">
        <property type="entry name" value="PGR5-LIKE PROTEIN 1B, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838764" evidence="1">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="246" mass="27545" checksum="7CA3CBFF6103670F" modified="2008-11-25" version="1">MNCLWLSFLFFQMSQAWTMFYPRTSSFLSKTAVKSSSSVEAELFVDENEMVPIAENYVRAKYKSMAQSHGKLACTNEGAGQILRSLLPPVTPAELNTEVSKTLATIMANPKNSDDTIEEDDFVKAIVNNSYWKAAGSLVVKELIYFDALHTYYRAGTPLLNNSDYETLRDNLTGEGSVVVNMKAKETIFVMAVASSRRGDPVMDDLQYTTLKRELKAQGSWVTARSQDTLEKLGLNTFMGYLHRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Z8</accession>
    <name>B5Y3Z8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185751.1">
        <property type="nucleotide sequence ID" value="XM_002185715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3Z8"/>
    <dbReference type="PaxDb" id="2850-Phatr36903"/>
    <dbReference type="GeneID" id="7204703"/>
    <dbReference type="KEGG" id="pti:PHATR_36903"/>
    <dbReference type="HOGENOM" id="CLU_1829125_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Z8"/>
    <dbReference type="OrthoDB" id="41869at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841250" evidence="1">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="141" mass="15886" checksum="2BBB0E400A68EE4D" modified="2008-11-25" version="1">MRRNVVLLYFVLFVSSSWAVVAAERRTIKLSLGAEAQSAFTGRRFAKVLDVPRGGGWFVPAGWNPFGYKITTLGDEFLSYDGSLDCDVGRFLASLKNRKRFSDIKSNWLEIVRVAKTGQAMRIYKNLQDMIQLCLKAGLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y450</accession>
    <name>B5Y450_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185778.1">
        <property type="nucleotide sequence ID" value="XM_002185742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y450"/>
    <dbReference type="PaxDb" id="2850-Phatr46898"/>
    <dbReference type="GeneID" id="7204442"/>
    <dbReference type="KEGG" id="pti:PHATR_46898"/>
    <dbReference type="HOGENOM" id="CLU_898527_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y450"/>
    <dbReference type="OrthoDB" id="48818at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33844" checksum="70677043D062642B" modified="2008-11-25" version="1">MLTRIWLKDGTMQDEDETSTTEPLPYDSLDGKIDSTTMDPSINSADILCGRGKTSFNHVGNRQFRDSVTNSLRAYMDADNRFEKSMVVHRIVDNIHSAGGRFLKKDYSSSQWFELSDQQAKEKVGHAIRDAVNAYESKVKGKQQKGKDLSPGGKPFHQDLDYTDRSLVAQHTMSLRDSYLTHYPINIPLQQTADRPSFPYLSSQPQSFQLPQSQPAMKAAHQNYSMKHRRMLDALPVEVIFDEASSKNVSSTRVKPSTDDGHDEFVARINAVLGPLPQDANDPMEPLLDKQYHGRDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4B7</accession>
    <name>B5Y4B7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_37028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185809.1">
        <property type="nucleotide sequence ID" value="XM_002185773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4B7"/>
    <dbReference type="PaxDb" id="2850-Phatr37028"/>
    <dbReference type="GeneID" id="7204771"/>
    <dbReference type="KEGG" id="pti:PHATR_37028"/>
    <dbReference type="HOGENOM" id="CLU_021949_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4B7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="577" mass="63182" checksum="B680D4D5F9D765B5" modified="2008-11-25" version="1">MTTKSTPKDLIDSFPHSKLTPIATATTEPDYLSLHQLQYEINDNAETLSSTLGDGQHGHLFLVISETEYLEMTDGIPCIPPVQPPFDPVHAANATAPQILFDLYHNAIKAFRNQLLEAIPIEYIESLGHPTRGFNKVSPLEILSHLWETFGKIQASDLIANDEHMKAAWHPPTPIQQLFQQLEKGNQFIIASGQVMDERIIARIGYQIIEKTGLFDLASRNWRYKDEADKTLANFKKHFQKANKDLALTATSSSAGYHTANQSTVTKGKSYCWTHGIVHNTKHTSATCEKQAPGHKTGATLHNKQGGSTKTYQYTPPSSVAPNTPPLASSPPFFPPDAIADTGCTGHFLSTNIAHIHCQPTVPGINVVLPDGRTITSSHITELNIPSLPPAARTAHIFPGLSNGSLISIGQLCDHGCTATFTSDTVRIALNNTVVLRGGRSPYTRLWTLDSPVTPNPPATELHAPVHDKNFANHLGDHSGTLADRIAFVHASLFSPQLSTWCKAIDKGRLTTFPDITSAQVKRHPPQSVPMVKGHLDQQRSNLRSTKPKVTLSASVDPDDINFDTNPVVQVSRYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4V1</accession>
    <name>B5Y4V1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATR_43944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="12"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186072.1">
        <property type="nucleotide sequence ID" value="XM_002186036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4V1"/>
    <dbReference type="STRING" id="556484.B5Y4V1"/>
    <dbReference type="PaxDb" id="2850-Phatr43944"/>
    <dbReference type="GeneID" id="7204173"/>
    <dbReference type="KEGG" id="pti:PHATR_43944"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="InParanoid" id="B5Y4V1"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="13">
        <location>
            <begin position="368"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACI65542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="493" mass="54054" checksum="DC468C59ADF8147A" modified="2008-11-25" version="1">MMILSSTAARATAKALSRPGSRALASQAEHNLTSGFNFLSDQDRIFTNLYGEQDWRLPDAIKRGDYHLTKEIMCMGPDWIIQEIKDSGLRGRGGAGFPSGLKWSFMPKETDGRPSFLVVNADESEPGTCKDREIMRKDPHKLIEGCILAGYAMRARAAYIYIRGEYFNEAVVLDEAIHEAYAAGLLGKNACGSGYDYDIYLHRGAGAYICGEETALIESLEGKQGKPRLKPPFPAGVGLFGCPSTVTNVETVAVAPTILRRGASWFASFGNENNRGTKLFAISGHVKNPMVVEESMSIPLRDLIDKHCGGMRNGWESVQACIPGGSSVPVLNKDQCGEALMEFDDLRAKGSGLGTAAVTMFDNTVDMVGAIRRLSHFYKHESCGQCTPCREGTGWLEDILIRMEKGDADKREIPMLEEISRQIEGHTICALGDAAAWPVQGLLRHFKKDIEDRIDNPKGFDHEAAFQKAWSGDPFDNNAWTKEHGDGKTYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y502</accession>
    <name>B5Y502_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_25714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186096.1">
        <property type="nucleotide sequence ID" value="XM_002186060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y502"/>
    <dbReference type="FunCoup" id="B5Y502">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y502"/>
    <dbReference type="PaxDb" id="2850-Phatr25714"/>
    <dbReference type="GeneID" id="7204200"/>
    <dbReference type="KEGG" id="pti:PHATR_25714"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y502"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="205" mass="24398" checksum="4FEF8A44D53FA8FE" modified="2008-11-25" version="1">MGAYKYMEELWRHKQSDALRFLLRVRAWEYRQRPNILTCNRPARTEKAHRLGYKAKQGYVIVRAGVRRGGRKRQNHRGMVFGKPKHQGINQLKFERNLQNVAEEKVGRRYANLRVLNSYWVNQDATMKYYEVILVDPNHPKIRNDPRANWIVNPVHKHREMRGLTSAGRKGRGLRKKGHRANGIKGGSYRAAWLRRNTMRLKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y552</accession>
    <name>B5Y552_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186410.1">
        <property type="nucleotide sequence ID" value="XM_002186374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y552"/>
    <dbReference type="PaxDb" id="2850-Phatr44034"/>
    <dbReference type="GeneID" id="7203994"/>
    <dbReference type="KEGG" id="pti:PHATR_44034"/>
    <dbReference type="eggNOG" id="ENOG502SUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1291201_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y552"/>
    <dbReference type="OrthoDB" id="48328at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="214" mass="23411" checksum="156D1733B8AC3CEB" modified="2008-11-25" version="1">MKHPATFVSGTRRARSQHSRTSLCVQFPYDHITSPFWIGNAVSTSPADSFEPVLNVPALGSFLFIALVFSLLRWRVGAIERAADRRTTALEGFRTIKSQALEGKADEEKVQLALEDYKRAVEEVENLRTIIPGVRIAPPPSTASLSTERSNENAAAARQFLGMELDTLPQQQSNEEGKQGLPVPLVLLLGLVAASQVGLLFLFLQDPMSSSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5S9</accession>
    <name>B5Y5S9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATR_44231</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186241.1">
        <property type="nucleotide sequence ID" value="XM_002186205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5S9"/>
    <dbReference type="PaxDb" id="2850-Phatr44231"/>
    <dbReference type="GeneID" id="7204064"/>
    <dbReference type="KEGG" id="pti:PHATR_44231"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340245_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5S9"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="517"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACI65711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="814" mass="91615" checksum="85F607BCE3A3E812" modified="2008-11-25" version="1">MPAIYLFHRRTIVGGDDLQPAAFLTASLRCVQLVCLLGPILAHIHDESSRNGGLFHYIMYDPSDDVSCRHSNLFPTLLTLYAVASVVYSFASIALEWRLAHWSSIGSPTETEPRSSKVRHLLELKLVPFSILLLLVWMSGLSAVAFAPLYNYCVDLTQQNNSEIQREMADDIDKYSVEVFTPLRVHLWWLALAILLVGQLSEVLVSFAFLWHLCKQPMQAHILENPELMEVTLPSHRMIEEMWADRCAAACQCLGSASCFMFGGRELLGQAEFGDVARALADYLDTGGILDVVPSDIVTGFMLLQRIQRQRIYRAREEVLQHVEVAARLEGQSVQDNAGDELMVPLDSLQSTSYLPSSSTTCRVGGRQSSVFRFDPDGTYERRNRALFERHNVDEMSVLEEGTRYAKYALAIYTWVLYLYVHPCSGIPRLFAKSGRLCCRSSKTDRRGESSVIPQLAANLIDQHGRIEGDNLCETNKAALLLTVGLMEADLIYAQLRSGFADTPYAILVDHEWKSIVVSIRGTFSLEDCVTDVLIDPEPLEQLGVDFGFDAKDQYCHGGVLTCVRNVYRDLQRHGILDRLLLGEHARFPEYRLRLVGHSLGASTCTLLSYMLRGKFASIRCVNYSPPDSDLVPRLSFNAMEILRNEILSLIGRIKVPKIEVASRVVSGSGLSNCRFCLDQDPDEHANILEDINEMLYAPTELPESEYQHQLERFQTVQEERRRSRGHLRSLQLYPPGKLVHLVKIGERKSCLHGLAKCLTCCTTNAGSKYQPVWIGNDDLNEIVVSPTMATDHFPNRLCDLLQTVAREYKVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP09</accession>
    <name>B7FP09_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176625.1">
        <property type="nucleotide sequence ID" value="XM_002176589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP09"/>
    <dbReference type="STRING" id="556484.B7FP09"/>
    <dbReference type="PaxDb" id="2850-Phatr42636"/>
    <dbReference type="GeneID" id="7195997"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42636"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP09"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="7">
        <location>
            <begin position="115"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="897" mass="99630" checksum="EE91E9DAA4AB14E4" modified="2009-02-10" version="1">MATAPAANSTQHQGPKLPPHSGDVDEELGRIRLALAAVFSPSNSGNGSEQWWAQRQLADQYLTSFQATSVSWMVCDRLLQGDISDVVAQDALPSLRDSLLAHLNRYAADGSEGPLSTRLAMCISALAVQMQWTTVVSDLLATPQNVHVVMLILRALPEECASDRLVLADDAYRFKMRDHLVSFAPNVLQFLHAHVTDASRVLKVLHLWIRYVPVHPQTLVESPLLNAAVQASLPLDEALQSDDEDVLRAYCRVVTEMGESYMSLILSPQYLEASQLVSWVLKCSGMANQEIASITLHFWYRLVMDLESVDPYDWRQELIDAYTPHLLQLIDVCIKSLMRYPADMDTIPEDLLDELTRHRFYVAETVEDCCRLLGGQNVLQRIGNLLQQEIHAASGNQVWQGLESCLACIGAIHRFVPSDEAELLPLTFQLVPQLPTEIRPLRYTASKTIGKFASWLAFHPHLLQPLMPYLAQGLSVPECAPAAAVAIKELCECSNQSFAIAEPVMELFQGLTPGTLEVEDELQILEGVCRALSRQMQDARGRGNDTQAALTRLAQPIGTRLAASVSEPNSSPRRIIPEIERLTVLVRYLVILYDGNATTGLHPMLELTTSIWSFLDAAVIRFPGDIVLAEKICRLHKHSLRSCGAQAYSPMLDRLMTQLVQSFERSHQSPFLYAASICIAEYGSDSTYSNRLLGMVSAMATTCFSFLRNVDELTAHPDVVEELFYMMGRMMSNCPDPLVQSPLLRSLLQCAAVGMQLDHHGANKGTLKFLENTISYGLSLREQKKPACQAPLEEALSQEGQAIVVNLMKAMMGDLPEYGNSQIPEILWKLNLLCPGLLTQWLHSAFAGTLTLPEGAKNDFIAALDTGLARDEFSMAVRAFQTACERQRRLRKGPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP69</accession>
    <name>B7FP69_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176656.1">
        <property type="nucleotide sequence ID" value="XM_002176620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP69"/>
    <dbReference type="STRING" id="556484.B7FP69"/>
    <dbReference type="PaxDb" id="2850-Phatr42688"/>
    <dbReference type="GeneID" id="7196026"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42688"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FP69"/>
    <dbReference type="OrthoDB" id="195747at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF24">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="318"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="700" mass="77371" checksum="DC207BABC6FA668B" modified="2009-02-10" version="1">MESIQPPSTAALVVSSTNARKTPIILSAVYGRKHSWTSLCAVAFIASYFWVARTIEAFSCISFNRAQYRSVSVTLPSALFRNGNILRASPSDYVHSFQSNATRTSAKNRSIPLHNPQNMTVIRKQSARKSALQRSSQKRPILARLGQLRNRVRANQTSPVGIDGSMGLPSQRECDQVLADCVALDEWELVLETLDLMKSVGLSQQHSTYLACLEACFPVANAASAKEILYAMEQAGVEVTADDIVWAILIYCRASSMRPRNDPVWLPLALQLIQEHPNVSVAAYDAVLSCMVETKQWKEAVRLLRGMEQQGSTGPALSTYRFVLESCVASDQPTQAVQVLQSCIHHGLVPTLYSFELVIGALAQKMQWRRALQLVELMRQIDVSPNLVVYNAVLSACSKAKEFLPARRLLHQMRREGVQPSIRSFNAVIAACASAGQWQDAIQVLDQCHREPGIQPDIYTYTNVMRACAKAGKTRKALTLLQVIKDKKLPLDAYAYTAAIEACAKATLRIAKRADLAFDLWAEMVDTKPFEVNSIAVAKLDEVSTPDIITVTDAIGALSSASDTVEDRYRVDKVFAEAVRRNIVLRSDTLDSKWEIDLSGMSFPVARAACRYVITSISKSTSNREFEDLTFITGVGVGKSFYKGSNGVPDLPTQQTSLQKYVQQILISDFHPEIESYVPSLAKGTICIGSESICKWAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPN7</accession>
    <name>B7FPN7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_31906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177243.1">
        <property type="nucleotide sequence ID" value="XM_002177207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPN7"/>
    <dbReference type="STRING" id="556484.B7FPN7"/>
    <dbReference type="PaxDb" id="2850-Phatr31906"/>
    <dbReference type="GeneID" id="7196480"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31906"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039242_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPN7"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000019">
        <property type="entry name" value="probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF7">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 12A1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="551" mass="60600" checksum="FE89ECA792C0DF77" modified="2009-02-10" version="1">MSNRTAKATLSSVMTKSSILVRRRSMSSIPWATMDPKALGTTAEPYAVPNIVDGKLTSTSKTIEIIHPLDRDAYPIFTVPDTQTGEIQPFLDSLRKVTKSGMHNPLKNPERYLDYGEISRKAGDALMQPDIAEFFIQTIQACVPKSHAQAAGEVRVTAAFLNNFGGDNVRRLAKSFGVPGDHYGQMSVGHRWPYGPVAIVTPFNFPLEIPVLQLMGALYMGNKPVLKPSEQVSIVMEQFLRLLHHCGMDEGDVDFLNCRGPVAQAVITQTPVRLTQFTGSSKVGELLAEATKGKVRLEDAGFDWKIIGPDVGDVDYVAWQCDQDAYATIGQKCSAQSICFIHENWKKVGLVEKIKSITEKRNLNDLTAGPTLTVSTKTFLDHTNRLASIPGASVLWGGEELENHKIPEKYGAVKPTAVFVPLEEMIKEENFESCVTEIFAPFQVISFYNDDTIDDVLSALEKMSHHLTAAVVSNDVSFQTKVLANTVNGTTYAGRRARTTGAPQNHWFGPAGDPRGAGIGTQEAIQLVWSCHREIINDNLVPTNWNQPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPX6</accession>
    <name>B7FPX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_31997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177291.1">
        <property type="nucleotide sequence ID" value="XM_002177255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPX6"/>
    <dbReference type="STRING" id="556484.B7FPX6"/>
    <dbReference type="PaxDb" id="2850-Phatr31997"/>
    <dbReference type="GeneID" id="7196467"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31997"/>
    <dbReference type="eggNOG" id="ENOG502RCX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929029_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPX6"/>
    <dbReference type="OrthoDB" id="47490at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="180"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="33295" checksum="2545C241C8EC3C48" modified="2009-02-10" version="1">MSRYNSHSNVTTAVLDTIISREASDREGIAQNQSLCRTMASRLAAPYGDLEQTLLPLCKENNAVAEETDVRAFLQEQRARIKKLAKGNVERERKLQIFLETLRTLKEQALNEANTDPSTDDEPMQVVDYKEKIETLMEQTRVEHQNTQLPMHQEAYYREILAELGEKEPVLVKKDGGDDDDDDIEFLNHQSSSEKSLKCPITMVLLEEPVKNKTCKHVYSKAGIMQLMGQKGFCKCPVPGCGNHQVTLVQLEKDLQKDMLVRRARRRQAADSEQQASQAEMQDSDEEEQEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPY4</accession>
    <name>B7FPY4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176791.1">
        <property type="nucleotide sequence ID" value="XM_002176755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPY4"/>
    <dbReference type="PaxDb" id="2850-Phatr42895"/>
    <dbReference type="GeneID" id="7196532"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42895"/>
    <dbReference type="HOGENOM" id="CLU_913553_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPY4"/>
    <dbReference type="OrthoDB" id="46098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="305" mass="33844" checksum="602F31BC58845DFC" modified="2009-02-10" version="1">MIPSNGGESSRKGNKRPLDVPPSTTSLYHPSIYRFYCRGAYFAHSKDKGSQGTCRGIKSRLELLSDMEMSTRADAIKNFTYMTDYELEDGNANDLNEQTKSILVSPALVYREDKNSKNRAEPLPEEELIKRQSWHCYGSTEVEYLVLKDPETGLQTISALAPRTEGLTIRKIITDDESLTSVAVGPINVVMQSSGIDTSDTNDDEVEKGHDVSRFPEEVPAKPSFVSLEAGQQAVTKVGDFSRRAAAQWVTNASWLAGTLQDEFPHRVYSAGEKIAAQLPRTVDQTIQYMGKIIDRYFGDDDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQB1</accession>
    <name>B7FQB1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_8827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176846.1">
        <property type="nucleotide sequence ID" value="XM_002176810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQB1"/>
    <dbReference type="FunCoup" id="B7FQB1">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQB1"/>
    <dbReference type="PaxDb" id="2850-Phatr8827"/>
    <dbReference type="GeneID" id="7196816"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8827"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQB1"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="219" mass="24467" checksum="1438E90873C33710" modified="2009-02-10" version="1" fragment="single">IESVVNLIKERRNVVVLTGAGISVSCGIPDFRSKDTGLYSILDAEELGLSCPEELFDWEVFQESPQPFYTFARKLYFPLGSDERAKPSDSHKLLSLLERQKKLLRVYTQNIDGLEQEAGVSSKKIVYAHGSLQFATCLTCKRKVSAKEIEPDILRARYENSLVCNGILKPGVTFFGETLHDNVGRSLEVDYDKVDALIVIGTSLSVYVCRLDVREVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQS1</accession>
    <name>B7FQS1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uracil-DNA glycosylase</fullName>
            <ecNumber evidence="6">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_8763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177455.1">
        <property type="nucleotide sequence ID" value="XM_002177419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQS1"/>
    <dbReference type="FunCoup" id="B7FQS1">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQS1"/>
    <dbReference type="PaxDb" id="2850-Phatr8763"/>
    <dbReference type="GeneID" id="7196748"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8763"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_1"/>
    <dbReference type="InParanoid" id="B7FQS1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25447" checksum="DF6642C9C9FC32D0" modified="2009-02-10" version="1" fragment="single">WRKELARHLDSASFASLASFVAKERLVNTVYPPVADTWSALNLTPLDQVRVVIIGQDPYHGPGQAHGLCFSVLPGQAIPPSLKNVYRELNEDSQIKFLMPRHGHLIRWAKQGVLMLNACMSVRRGEANSHQKKGWENLTDEIVRAVDRQSKKSGQRVVFLLWGKPATAKAQALIGSNSSVNRHVVICTSHPSPLGARKTNQPFLGSKCFSRCNQALTEMGCGAIDWNVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRI5</accession>
    <name>B7FRI5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176552.1">
        <property type="nucleotide sequence ID" value="XM_002176516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRI5"/>
    <dbReference type="PaxDb" id="2850-Phatr42504"/>
    <dbReference type="GeneID" id="7196684"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42504"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600612_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRI5"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="129"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="49797" checksum="9FE3414BD36478ED" modified="2009-02-10" version="1">MALSEDQNWTKEQLMGGGTAEQPSPSKKKGKGVEEDPMLWGIPGHLTSDEADTFAKFRAEVLKRDGDFRDTVYCFGEEEGEVWALGRWLRARKFVYDDVIAMVQEATETRKEAKAKDFYPDPVEALHVDTSLYFAQYPQLYSGVAKNGAPLFISKPGILNVDGVECITTLDGILKFHWYVMMHDFANRLRDQKKNNPGFKRVDPGLDSQRGLTLESSLVFCRFECVCILDLSQLTASKLTRRALAIIKEQAAVDAICFPETMCKMFIVNAPTFFTATWRLIRGWLDARTAGKIDVISSRATMEKKLLDFVDADQLPSDYGGKGQDTNVTLTQSMAGAARRLVTNVMYLRGHGSEVCLIHANEEAEIEVFTNSSAGAKFSVTDADAKSHIVDNVLVQHVGSGVESEQPSRKVITSQRITGPANVKVKADSNAGRFSTQNFLIVFSIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRS4</accession>
    <name>B7FRS4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_5099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177852.1">
        <property type="nucleotide sequence ID" value="XM_002177816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRS4"/>
    <dbReference type="STRING" id="556484.B7FRS4"/>
    <dbReference type="PaxDb" id="2850-Phatr5099"/>
    <dbReference type="GeneID" id="7197597"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5099"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032401_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRS4"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="157" mass="17587" checksum="AC3DC65622C06745" modified="2009-02-10" version="1" fragment="single">EDPEVIERVRCVIPDAHVFKLPPRQTAGGWRGADWDQEVWQGTLKVVERGALTVILLTDKTTHAIFAVCPVKEGAVDRCVDSSRYFVLRVENAAGRHMFIGLAFNERNDAFDFNTSLEDSRREKEAEANPEEGTDSGPPKDYSMKDGEKIHISVSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSB7</accession>
    <name>B7FSB7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_9987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177955.1">
        <property type="nucleotide sequence ID" value="XM_002177919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSB7"/>
    <dbReference type="STRING" id="556484.B7FSB7"/>
    <dbReference type="PaxDb" id="2850-Phatr9987"/>
    <dbReference type="GeneID" id="7197529"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9987"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSB7"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="350" mass="37413" checksum="491DA4C7D646F89E" modified="2009-02-10" version="1" fragment="single">VLGIESSCDDTGAAVVRSDGVILGEALASQQEIHEAWGGVVPGLARDAHVEKIDGVVEEALAKAGMTMSDIDAVGVTVGPGLEICLRVGCTKARELAIEHKKPFVGIHHLEAHILMARLPLSMDFPFLALLVSGGHCQLMRCMGIGSYTILGGTLDDSLGEAFDKTARLLGLPTGGGGGPAVEKLARDGDSTVVTLPIPLRQRKDMDFSYAGLKTAVRKVAEKMVADKGLESVDELPYQDKANIAASFQNVAIKHLEQRLKYAMTQLEEDSGIRTLTVVGGVAANTELRTRLQELCLSRKQPWTIIVPPPRLCTDQGAMSAWAAVERIMVGSSDDPAEQEVFARFPFSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSI2</accession>
    <name>B7FSI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177669.1">
        <property type="nucleotide sequence ID" value="XM_002177633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSI2"/>
    <dbReference type="PaxDb" id="2850-Phatr32745"/>
    <dbReference type="GeneID" id="7197562"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32745"/>
    <dbReference type="eggNOG" id="ENOG502SC0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460419_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSI2"/>
    <dbReference type="OrthoDB" id="206447at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65331" checksum="0596C4413890DE4D" modified="2009-02-10" version="1">MSLLPEKSLTKANFRPLPLKQRTSSVDQRRDYSTQTWTSLLGLLKVREFLVTVDHFSIWRRHLAWAFENGKDLRDYMTQRYASSMVFMSLLLSTELNVLFNSAGVTTQVRHALMTENLTSVSFWAGIAIIMSAVLTLLSLISTFTAWTMVSAVSENNAHCIFRSSIGQYAAELPGRFIVGSIYSFLVWLILFFFLLLPFGVWSIGLLLISLALFVHTITAFSAFGRVIMHTGAMGSQRIFDPSFEVNLHPHGLHNNLLVKAKANLTNCTSIMRQYRSKVKPINRQYSEDELSSHLSDRFSGALIPEAGPARKRTGSLVKFADGYDTNGDFYRKPLDPTLGLKKLSGAGQNRSPLSAVSERSSSPPNHPADLSLESVRALLPAASPRPSLMSRRESRDGVDMASPFEGLSPRNLTEDDNFSGVFERWLSSSNQSATSESFVSAGADATSPRIGSGDAKPGKDSLTDLRIPTFDEFNNHSALPGSIAASHSNSDQRDAIRRSFSAVSSLDDDDAAVLAEDERFEHEYGDLFEPERANFSYDFSIDGNSNSGTPPLSVADPTSRPDSTIGGNEDPERTALLSETDRLERGDYDSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSZ9</accession>
    <name>B7FSZ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_43649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177751.1">
        <property type="nucleotide sequence ID" value="XM_002177715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSZ9"/>
    <dbReference type="STRING" id="556484.B7FSZ9"/>
    <dbReference type="PaxDb" id="2850-Phatr43649"/>
    <dbReference type="GeneID" id="7197505"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43649"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="B7FSZ9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="775" mass="86544" checksum="DCDF7BDDC30B3698" modified="2009-02-10" version="1">MLLKKTTNPPMPAEQSLACHKFVTRLLHDSTDSTVNGTGEANFSVDKRRDLLRSAKHHDVASFVTRSRVCHLLFATQSGRAKACARRSARIISETVPSLTLLQNRVGATFDDEIKGDLQTFVKRTKQSNAFLLLFVSTTGDGEHTDTIRQTWQQFLGDRAYGPQYCAAGRKLAVRLMQLGATTFCQPGYGDDGTANGGVIADLDVWIDSILLPAIKALGLPNEGPRRSPSFISPGSRRAAYSVIVSDERRKGPLLDEWMEPGFSHAYSAFFSHLRPLTAYSYNGSLHRVETTGCVSRISEEPLLTRVEDNIRLTRSEWEQETRHIRLVAARKATQPETIAYQWKRNSLPYQAGDVASVIPSNDPEEVLKFLRALPPQIHENSDCILTITPKMLNTAEFLGVCCPFWPKRCTLYGWLIFCADIHALPEREDLRALSEFCSLEHEFGKDQRAKLISLSDLSGAALYGDYVLREKRSWADILHDFDSLRAPGSQLTVEVVLGLLSPIQCREFSIASSPSYEMMKMTCEASDKPNANGFAIELCVAKVEGTTPLGRAYHGLCSSYLSRLNDRRGESPSEVRMWIRPGTFSGLPLELSSESQSNKRLDVPTLFIGAGTGIAPLRGLIYEREAMFNLVNGLENGSMSNDINNIDENGLQCDNVLCFGCRKKDSDFYYEHEWQKLSQTGRLGMLTAFSRDQWHKIYVQQVLEKADAEETFLTNHLLHRNGAIYIAGGPNMARRVKQLIVESLARACGDDQKAALRILNQIQLAGRFSIEAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT90</accession>
    <name>B7FT90_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_33005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177799.1">
        <property type="nucleotide sequence ID" value="XM_002177763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT90"/>
    <dbReference type="PaxDb" id="2850-Phatr33005"/>
    <dbReference type="GeneID" id="7197255"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33005"/>
    <dbReference type="eggNOG" id="ENOG502SY68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2126094_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT90"/>
    <dbReference type="OMA" id="EGRWNDL"/>
    <dbReference type="OrthoDB" id="42927at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="127" mass="13349" checksum="04BB268D4DF635F3" modified="2009-02-10" version="1">MPQHSDSSFSAVTRHRTPYSTAGRPPSIDIVDDEWATDKLPDDDVDVSRHEAAVAPLMEEGELDADAIVVSPSGNSSAAAKNAAERRRRAEGWNDLGLDELDGGNVAAALTVAPANRSAPTNGSNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTR0</accession>
    <name>B7FTR0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_18877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178193.1">
        <property type="nucleotide sequence ID" value="XM_002178157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTR0"/>
    <dbReference type="STRING" id="556484.B7FTR0"/>
    <dbReference type="PaxDb" id="2850-Phatr18877"/>
    <dbReference type="GeneID" id="7198026"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18877"/>
    <dbReference type="eggNOG" id="KOG2492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396636_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTR0"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035600">
        <property type="term" value="P:tRNA methylthiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000001">
        <property type="entry name" value="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01574">
        <property type="entry name" value="miaB-methiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="154"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="455" mass="50963" checksum="EE7DA7561D8E49AE" modified="2009-02-10" version="1">MGQSRENKDISDLTYKLETMGCQMNMADSERIEGQLQGLGIRPLDPDVDKNKQPDVVILNTCSIRDHAEQKVYSYIGPHAKRKRDGEDVTIIVAGCVAQQEGEALLRRVPEVDLVMGPQYANRIGDLLEDVSNGNQVVATEASHIMEDSTKPRRQSTVAAWVNVIYGCNERCTFCIVPTTRGVEQSRPAESIVREVTELVEQGFKEITLLGQNIDAYGRDMIPKRKFSDLIRIVGEIPGLDRLRFVTSHPRYMSLGVVDSVAETPAACECFHIPFQSGSNEILAAMGRGHTREKYLHIVDRIRSRIPDAAITADVIVGFPGETEEQFEDTLSLMREVVFDSVNTAAYSPRPNTPAAVWDDQVDDAVKQNRLQRINALNLEHAAQRRARMKGRTVEILVEERNVRVPTQVMGRTRHGYIVYCDGEIDELRGKLVNVEIDTCEQYYLAGKPVAQDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTV9</accession>
    <name>B7FTV9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178214.1">
        <property type="nucleotide sequence ID" value="XM_002178178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTV9"/>
    <dbReference type="PaxDb" id="2850-Phatr44369"/>
    <dbReference type="GeneID" id="7197843"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44369"/>
    <dbReference type="eggNOG" id="ENOG502SUEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600620_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTV9"/>
    <dbReference type="OrthoDB" id="47491at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="50658" checksum="A7541328E7421A5E" modified="2009-02-10" version="1">MQTSTKSVFFVDASKALSLIHSPVRRVREDALPYWTYPGFEVFNGKNVEIAIAQNKLRRHRAAAHYTAKRSPSLENVDGRHTVDGCVLLNFKETLHHYRKNTFPLFSAGAYIRRGILLKEATKESKKRLRPDRENLFLAKPESGKPAKNSKTDATIPKMDAVETTRPFQHTPPARYNAPLIPFTVMMPNPYYSQMFLSGMPPYQAALSSSNAPKQTPETVLTVNGERSEQVKNDAIGKATLNKSKGEKKDVPSTEWFNNSIFYPPTMTPMQAAQNVLPQFLMVPRPTFTSPGFASTQGLINKGVPISLACDTEQLSEYQILIRHQLELFEAGPEDVESNTQGRKKPVVPMQVGLRCRHCATFPLRARGRGAVYYPSKLFGIYQAAQNMAGSHLCNSCQQIPYNLKQAIKKLRERRDNASGGKQYWADGARVLGLYETDAGLRMNAPVPKPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTW4</accession>
    <name>B7FTW4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178491.1">
        <property type="nucleotide sequence ID" value="XM_002178455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTW4"/>
    <dbReference type="STRING" id="556484.B7FTW4"/>
    <dbReference type="PaxDb" id="2850-Phatr44374"/>
    <dbReference type="GeneID" id="7198050"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44374"/>
    <dbReference type="eggNOG" id="ENOG502SQEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FTW4"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF32">
        <property type="entry name" value="THIOREDOXIN-LIKE 2-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="89"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="26168" checksum="0A0AD70E0A19DE25" modified="2009-02-10" version="1">MFVGIWTLRFHFLCRRRLCSWIFPSATSRNSFAPTFLRPSQGGDSTRSSGKRPYIASLQVVADAEDIDKDRGKRKHDEEETVSSSWIETGTGGFLPNFGSRKISEVATIEDYKKVVVEEPDLLVCVRFFAPWCRACKAVSSRFQRLANEYPKVKFVECPLTKENAYLHQGLGVPSLPYAHIYHPTAGLVEERKINKNVFAEFKNKVLKSYLDGSCPIEYDDEKDGKESLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTW8</accession>
    <name>B7FTW8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_10718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178494.1">
        <property type="nucleotide sequence ID" value="XM_002178458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTW8"/>
    <dbReference type="ESTHER" id="phatc-b7ftw8">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr10718"/>
    <dbReference type="GeneID" id="7197848"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10718"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570511_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTW8"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="279" mass="30764" checksum="14DD526DC34B6FD0" modified="2009-02-10" version="1" fragment="single">EFWDFRERIETPDGDWFHADIKKASGAALNAPTVVVCHGLESNSASPVSTGMAKAYANEGMNCVCLNFRGCSGTPNDRLGGYHLGFTDDLKQFLSILKERSGGRVYLSGYSLGGNVVLKCLGELGEDALYKYNVYGAAVLCAPLDQKRNADILASEPIYTSNLLKSLQKRAQNQLELFCDNDASTIRFDYKRAMDASNITEFDDAFIAPIYGFDSAWDYYDKTSAIFFLESIAVPTFILNAKDDPFMNPDVWPVEKTINGGGRAPIKMARTDYGGHLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU54</accession>
    <name>B7FU54_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_10948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178260.1">
        <property type="nucleotide sequence ID" value="XM_002178224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU54"/>
    <dbReference type="PaxDb" id="2850-Phatr10948"/>
    <dbReference type="GeneID" id="7197688"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10948"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328324_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU54"/>
    <dbReference type="OrthoDB" id="287671at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="120" mass="13714" checksum="0875A4C9303DC444" modified="2009-02-10" version="1" fragment="single">MEIRKRQALVIEDSLVVRKSLAQAFERLGFVVTQAVDGLEGLNALKETIFDVTLCDFLMPVMDGMDCVKQYRDWERENRPWFRQLIIGISAHANANDSGQGIKVGMDQFWPKPVSIKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUL9</accession>
    <name>B7FUL9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_34061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178340.1">
        <property type="nucleotide sequence ID" value="XM_002178304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUL9"/>
    <dbReference type="FunCoup" id="B7FUL9">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUL9"/>
    <dbReference type="PaxDb" id="2850-Phatr34061"/>
    <dbReference type="GeneID" id="7198094"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34061"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_3_0_1"/>
    <dbReference type="InParanoid" id="B7FUL9"/>
    <dbReference type="OMA" id="CKRSEYM"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEP"/>
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    </dbReference>
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        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="244" mass="26143" checksum="40F9E523EDCEBB61" modified="2009-02-10" version="1">MSNVHGLFSGKKDDSDSDDDANNRFVGGIGDRGGGSGLAVQPNMDEGPDRDAVFGLAENATAEDSGQSRRTITMYRDGFVVDDGPYRRLEDPENAEFLRHLAMGRTPRELVDDAGENVTVGLIDKRSEEYVEEFRSFSGQGTSLGTSTSVSEDGRFDPASLVEPPALDENRPTTSIAVRLLNGSRRVVKINTTGTVANLASSLRDSSDEPFRLVSGFPPKPLQDGSVTIEDAGLKGAQVSMQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUV7</accession>
    <name>B7FUV7_PHATC</name>
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        <recommendedName>
            <fullName evidence="1">Casein kinase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_7026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002178627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUV7"/>
    <dbReference type="STRING" id="556484.B7FUV7"/>
    <dbReference type="PaxDb" id="2850-Phatr7026"/>
    <dbReference type="GeneID" id="7197911"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7026"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FUV7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="11601" checksum="D0B10306EBDF1EC0" modified="2009-02-10" version="1" fragment="single">VYLAADVMLPLLQRMHEAGVVHRDVKPSNCVRSTGERDFCIVDFGLSKSAGFYRLEREKAEFRGTSMYASLRVHQGKDYAPRDDVWSLLYVFCDLVSGGLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV58</accession>
    <name>B7FV58_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179082.1">
        <property type="nucleotide sequence ID" value="XM_002179046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV58"/>
    <dbReference type="PaxDb" id="2850-Phatr34551"/>
    <dbReference type="GeneID" id="7199657"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34551"/>
    <dbReference type="HOGENOM" id="CLU_1242217_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV58"/>
    <dbReference type="OrthoDB" id="5981895at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855370" evidence="1">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="24866" checksum="549EBB26B77CA2FE" modified="2009-02-10" version="1">MGTRIWLIAFTAMLLVVVLTRVAFVSSDLDRIQAYSAVDWEVFSAPVPNISGGGLPLMKQRMSQPACDRCNHSSSMCSDLRAERTSLAFECLLNPSLSQCDYQCTDIPSSSDIVLPEELADSNMMWPSMNNGQWTTDPEYCRKYQNTSQTCLFDKYRWADGGDFSSFSPQGACHILHEHNISDLVIVGDSLGRHMWQGMMMVLSGDFNYIFVSSPVCQGETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV88</accession>
    <name>B7FV88_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IST1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178884.1">
        <property type="nucleotide sequence ID" value="XM_002178848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV88"/>
    <dbReference type="STRING" id="556484.B7FV88"/>
    <dbReference type="PaxDb" id="2850-Phatr11271"/>
    <dbReference type="GeneID" id="7199672"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11271"/>
    <dbReference type="eggNOG" id="KOG2027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772668_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV88"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19184" checksum="6669B8CDE3F993E0" modified="2009-02-10" version="1" fragment="single">LVLELKMAVSRIQIASNKKAALSKQKMREVAKMLSEEPPKEEKAKIRAEALIRDDNLMEAYEILQLECELIHERLKLIEYSRSCPPDMTSVISTLIWASHRVDIPELLAIRKLFCAKYGKAFEEAALANTNGVLNERVVTKLSVDPPAAYLVHRYLERICEQYEVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVC9</accession>
    <name>B7FVC9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178906.1">
        <property type="nucleotide sequence ID" value="XM_002178870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVC9"/>
    <dbReference type="PaxDb" id="2850-Phatr45034"/>
    <dbReference type="GeneID" id="7199539"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45034"/>
    <dbReference type="HOGENOM" id="CLU_496525_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVC9"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55777" checksum="DEF0A87643485186" modified="2009-02-10" version="1">MRTGNPASVRFHSPALRDPTPSSFHTNFRTAGDAMSTSKGAVNETTNASKAFGCFQQSIEEQSYPSTLSLTSTLSRPQSKGSHSMVRTRPLVSLSLSLLPTLVRLGTTSVTADASADCTVQLDGTCVSSLPRLECGVYMAPSTLGEDTNLGIYTGKALRTDDVVNFPEIAIPLLFREWGEHVEGIADGALWDRYIWEGEVADLETYTDRNRIDNRAVFVPGVGCTVNSVLDMNNIESTHGSTYDTAGLHRSRDPGTGAFSPYHSALTTAVTDIAPGAELFASYGDYWVPSIPGVQVTLDEVLDVTEDFLQNDLYEFVQSHRDADALTPDVKEALFAFVKDFPLPNQPFSNLPRNVPWADVERAIHEAGTHRKHTDTTTDNVSGESSVARQFIREQSIRDLAWLDEHGYCQDHLRPGRSTLPQAGRGAFATRNLPAGSVVGYAPLIHIGLHGREVLRITYPPSEHDHHVGNDDNDGENGTTPRTSYDLVLNYSFAHRNSTVILTPYGGMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW10</accession>
    <name>B7FW10_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178802.1">
        <property type="nucleotide sequence ID" value="XM_002178766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW10"/>
    <dbReference type="STRING" id="556484.B7FW10"/>
    <dbReference type="PaxDb" id="2850-Phatr34431"/>
    <dbReference type="GeneID" id="7199593"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34431"/>
    <dbReference type="HOGENOM" id="CLU_1067365_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW10"/>
    <dbReference type="OrthoDB" id="45721at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="261" mass="28560" checksum="19142FF3878CF642" modified="2009-02-10" version="1">MMLKEAKVLTLGESTNPKARTTWPSFRVHFDDDGYVTYLNLGSFRLRKGIVGLDAFRMFSKLSTLSLAGTDSPLSDLKVILDLITSTIECLYLGGNGYQTPVTHVLAPWIVSAAQLVKLDLRYNDMDSSGLSSLCDGLVGSNVKSLYLEGNRISDLAALGKVLECNSCRIQELYLGSNRVHALGAKQLASCLITNRSLRKLYLESNNIGTEGALAFVIVLQKVAGEVALENLFVDNNNIDREALKQLAKALNECTNIRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWB3</accession>
    <name>B7FWB3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_6817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179131.1">
        <property type="nucleotide sequence ID" value="XM_002179095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWB3"/>
    <dbReference type="SMR" id="B7FWB3"/>
    <dbReference type="STRING" id="556484.B7FWB3"/>
    <dbReference type="PaxDb" id="2850-Phatr6817"/>
    <dbReference type="GeneID" id="7200070"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6817"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724559_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWB3"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF274">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="106" mass="12668" checksum="8B9C569340B37378" modified="2009-02-10" version="1" fragment="single">PWTADEDDLIRRHVQRHGLKGWTLLAKERMPGRRGKQCRERWINQLDPDIDRTGWRFPEDLFLLQGLTRWGPKWALIAKQLPGRPENNAKNRFNAYLHPKIEKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWU6</accession>
    <name>B7FWU6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Creatine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_11733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179224.1">
        <property type="nucleotide sequence ID" value="XM_002179188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWU6"/>
    <dbReference type="STRING" id="556484.B7FWU6"/>
    <dbReference type="PaxDb" id="2850-Phatr11733"/>
    <dbReference type="GeneID" id="7200237"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11733"/>
    <dbReference type="eggNOG" id="KOG3581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019868_4_2_1"/>
    <dbReference type="InParanoid" id="B7FWU6"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="302"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40844" checksum="D26D8BAB508AA091" modified="2009-02-10" version="1" fragment="single">SLIRKYLTEAVYNDLKDKETTNGVCLDHMIRGAVSLPWGAKPPRGIGGVYAGDAESYQVFAPLLDPLIEDHHHADYRLRGQLRRHRTNLNPRQLLQQRLDPDGQYILYTRMRLARSIEGFRFSPCISVAERRQVEAILKNCIKDWKHGNKDSEYISVMNMTNEQHQSLLQRQLLFPDPDPFALCAGTHRDWPDARGVYCDDWQDPKILIWCNGEDHLWIISNAKGGDVQGVFTRLSTSVWALETSLEGRGHAFVEDKRLGFLNASPTNIGPALRASVFVKLVRLGRHPDFENLIRRLKLEARVYEETDRRYTGIFDIANSEALGKSEVELINVMIEGVGKLIELEKSLENGDVLDLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWV9</accession>
    <name>B7FWV9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_34853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179448.1">
        <property type="nucleotide sequence ID" value="XM_002179412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWV9"/>
    <dbReference type="STRING" id="556484.B7FWV9"/>
    <dbReference type="PaxDb" id="2850-Phatr34853"/>
    <dbReference type="GeneID" id="7200100"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34853"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_3_1"/>
    <dbReference type="InParanoid" id="B7FWV9"/>
    <dbReference type="OMA" id="SRWHKDY"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="35261" checksum="74B06063DD4371C3" modified="2009-02-10" version="1">METKITLSELIKPGNVAVVTGASSGIGRAACLRFAQSGMTVWMVDVDEAELGLAHQLVQQSQSAAAVGSDGNSTQIHARVVDVADEIAVQELATAVFARNGATHILMNNAGIGLGGGALTDMTTVQRVLSVNTYGPIHGCVAFVPKMKASDQPGMVINTGSKQGITMPPGNLTYNISKAALKAYTEGLEHEFMQERMEGVGKLRAALLVPGWVNTSILLKAQQHKASQQGQDFAVSSVSFHEEKPASGAWMPSQVIDFAIQEIDADRFYVICPDNDVDRETDNMRMTWTMQDVTHNRPPLSRWHPAYKDKFTEYVKAASENRKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA8</accession>
    <name>B7FYA8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_20066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179705.1">
        <property type="nucleotide sequence ID" value="XM_002179669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA8"/>
    <dbReference type="STRING" id="556484.B7FYA8"/>
    <dbReference type="PaxDb" id="2850-Phatr20066"/>
    <dbReference type="GeneID" id="7200391"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20066"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYA8"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="6">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="111"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38786" checksum="D12526CDBFDC4AB0" modified="2009-02-10" version="1">MRHPFRGLRERFETWALDHRKSYHTEIEKQKRFEIWAENHRRTLEKNERHGPCRLTEQPVFGSNRFQDLTDEEFQSSYLTGYSSSNARRLSFSKDSGVLDPSKNMKRHPEVHRPVDWRGIGAVTSVHSQGDCGACWAITAVETVESAVFLATGTLYDLSEAEVTLCQENCDMCYGGWPQDAFDYIMDHDGLPLESDLSYNGSLLLKLSQAKRYGQIEGYGYATSRCDEGVAVRNLATYGPAVVCVDASTWKDYSGGIITSESGCSQKFLDVNHCVQAVGYAYTSSGGGSESENGSHDSGSQDDSGSRQGYWIVRNQWSSYWGMSGYAWVAMGENTCGILNDFVQAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYF9</accession>
    <name>B7FYF9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179929.1">
        <property type="nucleotide sequence ID" value="XM_002179893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYF9"/>
    <dbReference type="STRING" id="556484.B7FYF9"/>
    <dbReference type="PaxDb" id="2850-Phatr45663"/>
    <dbReference type="GeneID" id="7200447"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45663"/>
    <dbReference type="eggNOG" id="ENOG502S1NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_1"/>
    <dbReference type="InParanoid" id="B7FYF9"/>
    <dbReference type="OrthoDB" id="43813at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF15">
        <property type="entry name" value="BLR3095 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="7"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="356" mass="39529" checksum="A6B4C65B30F87929" modified="2009-02-10" version="1">MSRKIVYMNNAGQAQLDQSVVAAGIACVQKPAWEMDAEEDAKIVRTLFAQMIHASPTNIAIMPSTAFAITLAAHNLKFQLEGQKGRILVLQDQMCSAVYPWEHLCSRSGGYLELDIVSYPSASTTWTEKVITHLKNGQDKILVACLPPLHWADGALLDLVEISKICRDIGAFLVVDATQAVGVYPCDISLFSPALLACSVHKWLRGPSGASLVYIDPKLQNTWEPLDQHGRSRKVAGMAIWNAAKDGMGPQGYPQEFVTDARRFDSGGKPSPFLLPMLRKSMLKVIEVDIEKIQSLLKDRMMPLLDWADKHELWTPSVHAYHLIGIRANTMYILLSDAGRFGFPRISTPPRKTYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYT6</accession>
    <name>B7FYT6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
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        <text evidence="1">Belongs to the HscB family.</text>
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    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
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                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="7200870"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR33418:SF1">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
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            <end position="300"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="482"/>
            <end position="530"/>
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    </feature>
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            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="79"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="588" mass="68014" checksum="0C95486F48DC7386" modified="2009-02-10" version="1">MADSVSRSRVKDSDDIEKSVRRSSRIRRPQRIPIHRLFEDDDLSVESDSALSQAGIHSSRQKYNRKRKAGEGLTHEKSEANSSKRRPKVSDVHGARGPEVRVHKRLIPVEDEPALIETIKREHADLLRSDEALEVDRAKKIKLQMVLVNNEWEQRFLEFLVFQRVYGHSLVPKNFMPNKQLGRWCAKVRCWYSKNDSRLTPSRQRRLNAAGFIWKAKKDPQFWKIQNQCEQAMDKWEDFFDRLLVYKAQKGDCLVPKEYPEDMTLARWVAKTRKHYKAKKEGRYHTLDDDKEMRLVEAGFVFNSKTQERLRFTVLKRFEGRWEEYFSKLEKYKERFGHCVVPRRWKEDQSLASWVMRQRCHWKRLQQGLHSYLTEERLAKLEEIGFAFVVARKGMPLHTGPDQEGSEDEDESNENDSDDDTESLRSDEVQPKISRRHRENAGMGLEGETQRSKRSALRESVSCVPAASVSVYVTAEVASGEDLTVSDPHQNKESKPESLDPPFSSHCTASNPTVHYDGEVKSTRSSSQGKNLLSAFRSSLAVKKSEEPPVIKGQWRCESCGKDEFSAFAEFAAHEHSCLALPEFATVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZL8</accession>
    <name>B7FZL8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_35508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179968.1">
        <property type="nucleotide sequence ID" value="XM_002179932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZL8"/>
    <dbReference type="STRING" id="556484.B7FZL8"/>
    <dbReference type="PaxDb" id="2850-Phatr35508"/>
    <dbReference type="GeneID" id="7200887"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35508"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763640_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZL8"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="320" mass="34864" checksum="E336E6B17EEB4D6A" modified="2009-02-10" version="1">MPSNDPLWAAASPNPSTSSWFAGATTTKLLVILSVVAYGTMHTQKTFPAWQFDAQLIRDGQWHRLFSSKVAFGTPGTALLGTTLGVLFSRQFERELGSRRFVSFVLFVQIVAVLLEAGLLATAFPYPWRYSGPYALLGAAFRLYHVHTPRLHPRFFGVLGFWCSEKAVYYLWMLQLTGSGGYSTVGATATGWLAAVLYTRLGSTSSSGIAHLPTVLDIPDWLVALWKPIGDRVGDVPPRLLVPRTAAAGRPGFAPAPHPIFGGQPLPPPAPTVRTPVVVEPDPAAREQLLLMGFDADAVEQALRETRNDVNRAADRLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZQ1</accession>
    <name>B7FZQ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_45758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180185.1">
        <property type="nucleotide sequence ID" value="XM_002180149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZQ1"/>
    <dbReference type="STRING" id="556484.B7FZQ1"/>
    <dbReference type="PaxDb" id="2850-Phatr45758"/>
    <dbReference type="GeneID" id="7200783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45758"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426712_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZQ1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="95"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="353"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="753" mass="82193" checksum="C523EBB3D48E81FC" modified="2009-02-10" version="1">MILRYSRSVTALSTTFPSVHVLARQRYRAQRLDPSFIGSAGRRGILTRMRSTATVIGHFNARRSSFLRPTFAVNEFSPICWYASTTVPLRSLPSIRILFASQGGTAQLFANMLSDALDEKNVPNVTVQSLADDTPENLVTSSLSSSSDSYYLFLTSTSGVGEPPSNGKVFYDWLMSQSNDSFPTDTNSNNRYYALFGLGNSKAHPSHYNVTSKAMDAKLNELKVMTPLMPLALGDDGDCLEDDFDQWQEAIVEQIVSRSTLNGESSTLQDDNSATTNTEDAPHAAEAPTPEPTANSDITVPTESMQCPGAKSGYRRAPIKYPRVLMGPPASSGSNGHAVRRDLLDVAPTFYHERTRAFPVVHNIALNPVASSNGLRELCVSLPAGDDESVQYQAGDHFTVYPRNKDYLVESYLDFVLDDVDPHAAILGNVSSTSTNSKPYPHPIDISLYETLSHAVDLNATPSPSFARFLLDGEDGSMDYKGDIVRHGRTVLDLLLQNSRAGQPKKIALEDLLYQLPPMKARYYSIASSEHTHNRQIYLTYRPVRYVTSRGALREGVATSYLSGLTTGSTVIAAVHANPSFRLPVDPQVSVCMIAGGCGVAPIRAFLEERIQRAPNSNYGPGWLFLGFRDPNDAVYGDMIATALECGALTHAQVMYNNPLGGDGTASSLTVDQQEASRGNVSDAVRRNGAAILAHLQNGGYTYLCGGARTFGVAIENEVHQILQTHGKMSEEEATTYLQRLIHEGRFLEDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZR8</accession>
    <name>B7FZR8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_45771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179993.1">
        <property type="nucleotide sequence ID" value="XM_002179957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZR8"/>
    <dbReference type="PaxDb" id="2850-Phatr45771"/>
    <dbReference type="GeneID" id="7200912"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45771"/>
    <dbReference type="eggNOG" id="ENOG502S7K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265776_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZR8"/>
    <dbReference type="OrthoDB" id="41192at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="947" mass="106356" checksum="431F151D770E3043" modified="2009-02-10" version="1">MIQYDRSPFGISTLCRMHGSAVYRATIPGFASVIFIVLIHELWLERPIYQEKDNELGHPYAIGVLVGTITFLLVFRTQQAYARYWEACSSVYQMMSKWMDASSHTAVYHLQCDHYDHIRPPSFYDYPHLNAEFLTRDRETHDPNSTGVMESMRMQKRATTKSIEQIETCRLAPAKPKRKVWERRSSDTKSESSSRGEDTPVPLESDPRLDGNWGALFDDNRATFFDPKFPDSIDKAGFASSQGGNTPPLFLQELAHLTSLLTGVALATLRNDIEGAESPLDIYEAGSPWPEVDPDKMADATFFGAGFTAMKISNFIGIGRTPEERTRYNASRPLAVLGGVSAAEIRFLQMARGPYAKTQLCWSWLSEFITREHLAGSTGNVGPPIISRIIQFLGDGMIYYNHARKITFIPFPFPHAQLSVVYVLVTVPAVAFLMDQYTEKLWVGCILTFLTVTALAGIHEVARELENPFRNVPNELPLVTMQAQFNEALLTMYAGFHPDNFWKEDADRYSKKKKRTTAKKCVQSNGVNSSESCPRQAPEGEAPETRTNHEKSLDAKIQELLEKIDQQGSELARLRATVVSGIKDPESQPVEYHRQAEEQMISIASAIVYQWHLKVLGMEIFRTSFANLGKHFWATATGLFLALSGMASLFHEGQIIFSLSSDSPFAATHGVDELHPTSAISEMRSASDRQMQQNKTETELLVSYRNRFEVVPEITRPLVETIPGDSTAPTSRAFNTSQADRADIKEEPGRKQNWSRMIIPWPVFVLSLPKSGTSSISSYFNCGLKHRQSAHHWGKMNSGKQNKLGFCFLDNVRGNRPMLNGCGKYKVWVDAGVPSSRGKCFYPGMHGLDNIVTNYPNATIVLSTREALNWVRSVRKYAGGTLMDKWQRNCPDFPNANSTELEWAVFYDGYNDSIRKFSIANPSLTLVEVNLESSLAPSVLKEKAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZU4</accession>
    <name>B7FZU4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180559.1">
        <property type="nucleotide sequence ID" value="XM_002180523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZU4"/>
    <dbReference type="STRING" id="556484.B7FZU4"/>
    <dbReference type="PaxDb" id="2850-Phatr12641"/>
    <dbReference type="GeneID" id="7201523"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12641"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZU4"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="27106" checksum="44E57DE3EC92081B" modified="2009-02-10" version="1">MEDDFVCAPDFAAVFDGHGGKAVSEYLRQNLYAELQAALPRVMGAQISETTKTTDEKMPSPSGKEFCNTLSDPMMIQSKRTIIAANIGDSRAILSRNETAIELTRDHKPSDPIELDRIHSLGGRVIWHGHVDTHGDPIPGTGVYRVNGNLALSRAIGDRSERPAVTADPDVSILPIDEADDFLVLATDGLWDVMTSSDVVAFIHALIEQGEDIDRDPIAAMVVEEAIRRGSYDNITVLIVWLNPSATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7G044</accession>
    <name>B7G044_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180613.1">
        <property type="nucleotide sequence ID" value="XM_002180577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G044"/>
    <dbReference type="PaxDb" id="2850-Phatr46119"/>
    <dbReference type="GeneID" id="7201451"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46119"/>
    <dbReference type="HOGENOM" id="CLU_1819605_0_0_1"/>
    <dbReference type="InParanoid" id="B7G044"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="158" mass="17518" checksum="88604A2DE7686142" modified="2009-02-10" version="1">MSQRHTGRVYTVRDTPEDTDDSLYLVLQLMIVFLTPSAKHVMVNLSSSGIKEGFASVIALQDAGAPLICQSHHDHCNWDWQCLFLPGRHRRPPLHLGKEQILMWHLGSVAAACPPQDPALGKGLQQLAILSQMVHACADLHRQGPSPGRSQLWCDIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0W7</accession>
    <name>B7G0W7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180744.1">
        <property type="nucleotide sequence ID" value="XM_002180708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0W7"/>
    <dbReference type="PaxDb" id="2850-Phatr46345"/>
    <dbReference type="GeneID" id="7201615"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46345"/>
    <dbReference type="HOGENOM" id="CLU_460416_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0W7"/>
    <dbReference type="OrthoDB" id="57390at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="593" mass="68910" checksum="D3A4182E92E8E242" modified="2009-02-10" version="1">MSGGNSLNFGSQNVFHEEEVIEREHDLSEYAEEEEEIDDEEDTHCHEIYDTDEYDEQIIESIFDLKEDPKTQEEYDCQIRKLIPIVYKDQDVDADSMIRKCPVQSELYIYLKQMYWYQKHNGAVTEEVNDAQEVVEDQNKLPLAAKTRSIMEIYARRALSREQTSDRPNQSSFDDEESIDDNGDETEENYDSESERDVDESVRSSDALKEYALRALGVSSGPEWEKATAINIHHDAISQVHKALDICHNGRGRQDMLFRSHQFSGRSTLLHSDGSEKCVNEHDEFDPDEARKDERDSRLERGEDWIVKREIPGSTDVGEAGNAPHIQNGSFDQEEDEDETEYDEQVIESIFDLKEDPKTREEYDLQIRKLIPIVYKNQDVDADSMIRKCPVQSELYTYLKQMYWYQKHNGAVMDGTDEDDKSPEVKQREDGSPKAKKMTLMEIFVRRALLGESIHSDNHADENKVCSLSESIVDDFCEDADIVEEAYTHKYCGYRDQAGTVRNPDESNDSSKEIEVMEETEVEELVDDSGDEEDVEIVFDGSEREEIEEEYVEEIEETDTEYEEEIEESSTAFKETKDFLLRLQDDVKAFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G138</accession>
    <name>B7G138_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180784.1">
        <property type="nucleotide sequence ID" value="XM_002180748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G138"/>
    <dbReference type="STRING" id="556484.B7G138"/>
    <dbReference type="PaxDb" id="2850-Phatr46405"/>
    <dbReference type="GeneID" id="7201655"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46405"/>
    <dbReference type="HOGENOM" id="CLU_347340_0_0_1"/>
    <dbReference type="InParanoid" id="B7G138"/>
    <dbReference type="OrthoDB" id="49596at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909:SF1">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="710"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="813" mass="87833" checksum="CDA84DBD715BB466" modified="2009-02-10" version="1">MGFFAKLFRRKGGSSNNDENGDPRSLRRARKSVKPTALPSSPEDDHGAPGPDDALVPSSPRTAAATTPPGRHRPDETHGSQRPSTGNRHDRIVLGPRNAEASPAESNGSSGTGQPIGKYSGPVDLDDTDVETADESNERLSRAHLEQFDLLQELTGETYRSSSNNNSTKLDDNINLAHFPTFNMTEPATTRFSAGSDTLVDGMDDARSDAESSTFNVSTDAEDTEYESLRRSGVLPKHLLVNRKVANLSLDEDTSAVQTDGETSLFPNLLTDDESNLTDSSFSPQRKLVNLKKTPASSSRMQIVPVMSKETSPTSPNSNNDSHTSMSSSWKSPRTNGDDGFGSSTVVSFPNTYSGSTQTTASTSPRVLDTAKSADHTSDFAVDPFADFADFSQADFNGQQQEETRQNNQISPVMNKTPRLLEDSTSLTDLLSKAKSKSRSRKSGDSVNSAPAMSSALVRDHYSLSRTKSSSRTTSKYSGTEVRSSHESGASVSDIIKNLEATQPTPNSRRYRGDAMSAHSRDASTSIRSTKERIRARRRGNSRRTSNADSDEDSDGDKDNDRWLFDEVAGALGPRGIAADLESLSGRSNRSRSSGGARSHKSHRSHRSRSSRRLLKGSGESVESHGSRRSRSSRHSRYSTRSYMSQMSEQSRSVANDLLRLEMQLAMVGEGSATEDAATRHSNGSNPRRPAPSASPRRPLANTAAPRRSRVTVTAPAGKLGIILANRSDAKGTIVSGVRTSSVLVEKVSPGDRIVAIDGEDVSLMAVSEITTIMARKSDFERSLTVLTTPRAISAAIDSEAASASFQQRYNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G155</accession>
    <name>B7G155_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHATRDRAFT_13154</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180792.1">
        <property type="nucleotide sequence ID" value="XM_002180756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G155"/>
    <dbReference type="STRING" id="556484.B7G155"/>
    <dbReference type="PaxDb" id="2850-Phatr13154"/>
    <dbReference type="GeneID" id="7201783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13154"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_1"/>
    <dbReference type="InParanoid" id="B7G155"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098809">
        <property type="term" value="F:nitrite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="20">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-rubredoxin oxidoreductase C-terminal" evidence="21">
        <location>
            <begin position="353"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="BFD-like [2Fe-2S]-binding" evidence="19">
        <location>
            <begin position="461"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="18">
        <location>
            <begin position="604"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="17">
        <location>
            <begin position="676"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEC47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="885" mass="95814" checksum="2A6814662582B149" modified="2009-02-10" version="1" fragment="single">SKKRVVVIGNGMVGQKVMENLLKIGAAADGNEKQLQLSTFCEEPRAAYNRVKLTSYFETRDPSALSMTSEFDKEGKTVWYDENGVELLLKDKAVSIDTEAQTVTGQSGKVLSYDACVLATGSFPFVPPIPGKQRPGVFVYRTIEDLENMLQYAQDNNVKSAAVIGGGLLGLEAAKAAKDMGLESHIIEFADILMCRQIDQGGHNALVGVIEDMGLKVHCGARTESFVGQDGSTDMESMSPVSALRFSNEDWEDLPVQMVIVSAGIKPRDELARDAGIAVGERGGVVVDDQMRTSAKGVYAVGEIALYNNFIYGLIAPGYTMADVAAKCLADDFGIGKALDPENLPAFTGADMSTKLKLLGCDVASFGVNQPRSDDKDVSEMVWNDPVSRVYRKLILNKAGTKLRGGILVGDAADYDKLHKLAVKSEEELTENPAMLLPPISARGGVAEENEGVSDDPTAQICSCNDVTRGDIASTIVELGVEGATLSAVKKCSNAGTGCGGCEPQVKDILKQELAKLGGTLSNHLCEHFSYSRPELMALVRTDTDPSSVDSFEKVLHKHGHGDGCEVCKPTVGSILASLNNGIIIDDGRDALQDTNDRAMANMQRGGSYSVVPRVPAGELLPDQLIALGVVAKKYDLYTKVTGAQRVDLFGAAKHQLPDIWEELGQAGFESGHAYGKALRTVKSCVGSTWCRYGVQDAVSFAVEIENRYKGIRSPHKLKSGVSGCVRECAEAQSKDFGLIATENGYNLYLGGNGGTNPVHAELFATDIDEKTVIKYLDRYLMYYILTADRLERTAVWQKKLPSGKDGSGPIGHLHEVIIEDSLGICDELDTRMEHLVDTYHDEWAEVVKDPARRAKFKQFVNTDETLSKDSMIEFIDMRGQKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1D9</accession>
    <name>B7G1D9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180838.1">
        <property type="nucleotide sequence ID" value="XM_002180802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1D9"/>
    <dbReference type="PaxDb" id="2850-Phatr46483"/>
    <dbReference type="GeneID" id="7201573"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46483"/>
    <dbReference type="eggNOG" id="ENOG502SBIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685994_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1D9"/>
    <dbReference type="OMA" id="NDCDETR"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="402" mass="43508" checksum="3E18AC747FFA00B4" modified="2009-02-10" version="1">MNNFFDRFKPKSKDKSSKGRGNPLASLGLGGPKTFGGKGQSLGGNLPGEIISIELSEHGPLGLQVEKRSNTQKTAIVAMVVEGSQAEKAGLQRGDILCFQGSEGMEEILYDMFLELAKSNQRPLCFEVRRVSTRQVASTSTSKSKSSADSYARKQAVIAAAETREKAAKQKYKPIPKTKNLPTLLSAAERQQIEEDRLARAAAHHLGDAPQTEAAKAAAAAAKEEERKLAVTLGYNPYEPNRTTAGQARHATVATKHGSIKSSSQENGIPSVAPPKDAVMPEVDDTDACSDEFEAAFELTVTTNSHDIIVNSFGILRKLMINATTKGQQEGEESAKFLRVRLGNPKIKATVLDVEGALDLMRTVGFEWLEEGGDSFLVFPKGCQGPLWLPSALRKMERYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1J1</accession>
    <name>B7G1J1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Photosystem II Psb31 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180868.1">
        <property type="nucleotide sequence ID" value="XM_002180832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1J1"/>
    <dbReference type="STRING" id="556484.B7G1J1"/>
    <dbReference type="PaxDb" id="2850-Phatr46529"/>
    <dbReference type="GeneID" id="7201679"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46529"/>
    <dbReference type="eggNOG" id="ENOG502S4K1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1528228_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1J1"/>
    <dbReference type="OrthoDB" id="202886at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1740">
        <property type="entry name" value="Sodium ion translocating NADH-quinone reductase subunit C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040933">
        <property type="entry name" value="PSII_Pbs31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18240">
        <property type="entry name" value="PSII_Pbs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855297" description="Photosystem II Psb31 protein domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Photosystem II Psb31 protein" evidence="2">
        <location>
            <begin position="60"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="183" mass="18956" checksum="E5ADC9BD2C626699" modified="2009-02-10" version="1">MKLSVVACALLASSAAAFAPAASQRSSTSLNMDRRAAFGAIVAGAAVVATAPNAAFADGAVSGATVQKARTVYGGRIAELKEAVNKGDFGAVANEKSAFVLFNSGAYPTSKSKEEKKAAISSTNKIFAAVKAGDKAALKSAYDEYVKTNDIKPFPKVDPKNGQGYSSDYDYRVRTPAAAIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1M6</accession>
    <name>B7G1M6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemolysin III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180884.1">
        <property type="nucleotide sequence ID" value="XM_002180848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1M6"/>
    <dbReference type="STRING" id="556484.B7G1M6"/>
    <dbReference type="PaxDb" id="2850-Phatr46556"/>
    <dbReference type="GeneID" id="7201698"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46556"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_2_1_1"/>
    <dbReference type="InParanoid" id="B7G1M6"/>
    <dbReference type="OMA" id="NAWTHLV"/>
    <dbReference type="OrthoDB" id="186812at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30039" checksum="769EE5819EACFA28" modified="2009-02-10" version="1">MANADGILEAAHPYYPHASEYGHELPQQPPEVWSITDFGRVNERSRDGSVHATDEVFNTASHFAATFLSFLGTVLLVVQASARHEPWKIVSFSIYGASLVFLFAASTLHHGLTGVHEAFFRRLDYLAIYPLISGTFTPLCLVFYHDSLIGWVFGATVWAIAILGMVATAFWFHKIPKWLSMTAYMTLGWLGACMTYWLIPVLGMDGFGLFLFGGILYTGGGYVFYTERPNPYPGTFGFHEIWHVTVVLAATCHWLLMYTYVLPWESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1N4</accession>
    <name>B7G1N4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_46563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181062.1">
        <property type="nucleotide sequence ID" value="XM_002181026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1N4"/>
    <dbReference type="STRING" id="556484.B7G1N4"/>
    <dbReference type="PaxDb" id="2850-Phatr46563"/>
    <dbReference type="GeneID" id="7201846"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46563"/>
    <dbReference type="eggNOG" id="ENOG502QSGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007113_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1N4"/>
    <dbReference type="OrthoDB" id="39300at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855302" description="G8 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="10">
        <location>
            <begin position="72"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1245" mass="136552" checksum="A1E25C6B8D9336E8" modified="2009-02-10" version="1">MYSHLVLGLAILFLGASQCNSNLIRGNSSMSASEAGDSEALTTTISRRLVENFVPLRCNAAIGKAPCSSFVTMFGNGAVRSNRVIIPCGKCVTMDYPGPQLTLNDGIDIRGKLVFPDGYRLTVRTNLVSVQGELEMRSSKPVDGNPDVRFVMQGTESASFAPISSNAAKCGGNCDAGARSIAVAGGKVNLNGLPTSTPTWLHVHDVIGSSAIVVSNSVRNKWGAGATIVITSEHQGYFGEQVRKITSISDVGSNSVRLNLDQPINRPVTLRDSPDFATEVALLSRNIVFEGAPGTKGGHFWIMHTPRVRQRIEGVELVNFGQEGLLGRYPVHFHMCGDVSGSVVVKNTIRNSNQRCVVVHGTNNLLVQENVAYFTKGHCYMLEDGIETGNQFVRNIGIRTVKPEIIIPNMGSNGKESDMTASTFWITNADNSWIGNVVAGSEALGFWFELLVRGNLANEHQDFDPMMVPTRKFEGNVVHSVYGVGMTYYLSGYIPETLQYFKNNKFFRNHHLALRIHRARNIVLTGNKFSDNRYAIRIDRDEEIHVTDTTIVGYSDLFKDVVRRNRFAQAPCAQGISFQSTNPWKDKMDSELNGVILDKVRFSGFSNAVCSSSTAIELDSRLDGYKSFEMFSQYSGATVSDANSIDFCRGKSAGARDVYVSDTTGSLLDGVASAPSTLMVNSPELASFVNPSACTENAARCYTYCSNTCFRTVHYYVPVGQSRDYKLKVCDRKDASDCTVLSGYVHSNHPWPRRFAVHVPSGREYDTYFLDKGVPVYPTNVEIVFQEKLCPTAPDDDDIALLYKARGTTFPPTPSPTTALAACGNLIANSDFERGFNGYWDAQGAGTLSTTAGYESATAMYYASGNRNRYWVGPSHQWREGLDLKCLKQGTIWEFSARLKLVDSKTGRGASCDPGSSSGGEMCPQVQLIVRDQSWTQHSFRISGFDGGDTWVANGFNEFKGYWTIPANGSGWQGGVANMRVILSEFPFGMDLVVDNFSMVLTFDTNKSLAQSPTLSPVLAVPPPTQAPIRIPTQAPVRIPAQAPIRTPNESPLIGPGTDLNTCAKMIANSNFDLGYEGYWSVPSGGSLSNKEGFSSSTSMYYDSGNRRRYWIGPEYKWPNGVDYGCLLQGTTWKFTAKFQLIDAATGKGSSCSVNSSKEGEMCPRVRLTLRDDGWTLRNVRIDGFSAADTWDANGMNSFTGYWTVPENGPDWQGRVRNIRLAIADFPFDKNLVVDDFQMAFFNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G210</accession>
    <name>B7G210_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181295.1">
        <property type="nucleotide sequence ID" value="XM_002181259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G210"/>
    <dbReference type="PaxDb" id="2850-Phatr37058"/>
    <dbReference type="GeneID" id="7202085"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37058"/>
    <dbReference type="HOGENOM" id="CLU_1859166_0_0_1"/>
    <dbReference type="InParanoid" id="B7G210"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="13026" checksum="703DB92A7722A13E" modified="2009-02-10" version="1">METPDSKSGAANQRPQYHYFYGSIDDQSQVNRRENAVSVPTDQDSLVGESLLPTDNEQDDDRSKIAKQDFQQIVMSNVNGVRPIDSSRSGQSDKNTQGRVELSHAVSSGGSGTVRRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Q8</accession>
    <name>B7G2Q8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181249.1">
        <property type="nucleotide sequence ID" value="XM_002181213.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47168"/>
    <dbReference type="GeneID" id="7202061"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47168"/>
    <dbReference type="HOGENOM" id="CLU_250486_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Q8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1524" mass="171582" checksum="676F0EA7334A36AE" modified="2009-02-10" version="1">MSKSDHSRNYGPEMAQSPGTSTLFSISADEHSLMNRKKCARRISHRTIWQGIERLADRMADQYLPEELRGTFSIEEESVFESESPLFSEEFSNETESNSDTDGAPYFEDTSQAFESPRSRDHHIRTRSILFVEPIKRESRQERQPNEASEEICLVFQKSLEFKATHSVQSATSLGVENGCRSNEFGPEVCDSVSRSSGVISKCSPPFLKDEGAKVPSFKFNSVPPEARRFFKTWRQGASSKVPTPMLSTKTNSEFPALPAISPRKRTSSGMFNVIQNKETLSQRDSIIKTSRLELAKKSSHVAADNSREDILPLSLSDEENEIIFHFSSTSSLLENSSVREKVDALEQELNPFETSDEKHPTAALKYTIPYDKDGNVEVVPALISSPRSFTQRRRLFSKLREGRQRTFLWEKKFADLKLKVKADDQSLLCEINRQENNKILGKKQMGRKQSIELMSPSRTAAPQSTRATPPLELVDKAIRSSQEERPCSKPASPLDSGSVASKLTTKHSNALGRCYKEVGAQAYVEDSTQSWEIARKSSKERHSTILASEKDFEVNVFLSDATGTLKDVRASEEIMIDRATQSIEVDGGSLAYSLVPYGDEIRQPIVTSSLSPMKLALQVPFHVQRTQTHSTGEVEVECQSTTKSSSVTQETARVKRKKRKESPHGQMVGFKPRNDFPLRKSSKIVEPNINEPEDLVMIGTDCHGSCKKPVRSMVHSLKKSSQRCKDHRMTCAATKRRGLDAKCDRIPTEPESSPYQIRSNRLSTSKLKSSRASLTPVEKKLVGPHDTSSLIDLPPKAAPPREGAENYLSKLKTVTETSMRMSPHRSYGTQVYPEHSNTSGSVEEIYEEASRKDDKVHHIDTQPVNSGQKKAKTRADFHFSLRRIRALSRLHKVSVGMTSKKSGSSIISLSTESIPFEDCIYAHKILSPIRLSEKEHVEPILHEKRDTYRNANMLLSDDGSNRDILQCTKHISLERKLDCDKKQILQRSPNIGGLVKVQSLCIDCVSPNGGVEVPRLEFEKQIARGWTRWSGRKFAVFPPKISARARTETVRIHDRNIGSLYDKPVNSNIQAIFVETEEHQALKSSTTALNARCQHGLSPTKPNSMHLFHEGDLGTDEKGEIELKRCLQQKPDLQAIDTTLIPQIPLLRPSGNGLPSLPGTVSTCFDEKVAIAAAKSNTEHSVEFTTQRRGLDLQEKDAKQTNPLLILSGNKFSADNKVCTIPNMKQPATVQTIKKIEVVLLSKRKQAKAEKDAEFLCIEKNWSPQVSTDQSSSINLPSFEKVNESQNLESFDVRRSAGSTGGLARIENQRIRKESTIQQRNALNLSQENREHEQLDVVDRDDKQRTRRISNEQVKSKYSHRARMLESSSACQQNSKPLPFRVNAGTRERSHSVTKTMKSDQSQSAGRSREERINEVEKKLARRRAADIKILTAIKNRKERADRRRVCDRGVKYDNPMHSSVLLQSVEGLLRRRSQYLQEDRNKGEEENINLKTTALTCVFSRMLSCTQDEGRDDENVDSCKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G334</accession>
    <name>B7G334_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_47361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181718.1">
        <property type="nucleotide sequence ID" value="XM_002181682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G334"/>
    <dbReference type="FunCoup" id="B7G334">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G334"/>
    <dbReference type="PaxDb" id="2850-Phatr47361"/>
    <dbReference type="GeneID" id="7202513"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47361"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_3_1"/>
    <dbReference type="InParanoid" id="B7G334"/>
    <dbReference type="OMA" id="SAEYSWR"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="170"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="489" mass="54999" checksum="6A8A591B7AC63451" modified="2009-02-10" version="1">MKSCIQLGHFRQSFRGKKSCGWVGLSAFSLNTFALFSRGTIALCPPLSAAPYRIRPTSYRRLYVTTALRMAPRSSKKEPDAASGTPNKHDRVTRGSTKTPPSAASIDSQKTSEAPLKKSAKRTLPEDTTKENSPKKKAPTHQVLTERDDIPRLWSDEQAAKNGSYTMRIASWNVAGLRALMRNSPHALSDFVREHNVDVLCLQETKLQESHLDDPKLKIRGHLLEKEGFDSYYSCSTARKGYSGTSVFVKRRQLIKGSKVAKKQKTLGSYFGKNDERETSSNSLKGTEELSIDPHLLVPEGVSFQMNVDKHDSEGRIVVVDFPSFTMCNVYVPNSGQKLERLSYRTEEWDKDFLSFIQKKQKDRGVPVLWLGDLNVAHTNLEVWNDGAKHLAKQAGVTAEERASFEAQLNAGFIDAFRRLHPTAKGHYSYWSQRAGNREPNKGLRLDYFICDPSLFDEESKTIVRDSYVLPLQQGSDHCPVVLELEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G351</accession>
    <name>B7G351_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181556.1">
        <property type="nucleotide sequence ID" value="XM_002181520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G351"/>
    <dbReference type="PaxDb" id="2850-Phatr37567"/>
    <dbReference type="GeneID" id="7202421"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37567"/>
    <dbReference type="HOGENOM" id="CLU_1424039_0_0_1"/>
    <dbReference type="InParanoid" id="B7G351"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd07812">
        <property type="entry name" value="SRPBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20995" checksum="65D5879F001DD7E0" modified="2009-02-10" version="1">MSSNSRSAFPHSLGISKSLDISASASIVWALLVDVDSYPNHLSTCMSVRVYQPHPTNRRNPRGSSNASQNVGSVKAGSKWVEVRQFKGRTYKMLVSTTAVDNEEDDPKSFTVATDALGSTSTATHTLTTIDERSCRLSLSYGIVPHRWWSQIYFACFKRILRKDCLEALEHDLADIAKAAVAVATGQDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E0</accession>
    <name>B7G3E0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181602.1">
        <property type="nucleotide sequence ID" value="XM_002181566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E0"/>
    <dbReference type="STRING" id="556484.B7G3E0"/>
    <dbReference type="PaxDb" id="2850-Phatr37658"/>
    <dbReference type="GeneID" id="7202565"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37658"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_1_2_1"/>
    <dbReference type="InParanoid" id="B7G3E0"/>
    <dbReference type="OMA" id="PWFKEQD"/>
    <dbReference type="OrthoDB" id="420389at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25515" checksum="78C3F7DA3594A45C" modified="2009-02-10" version="1">MTPLPKIKLTYFDIEGVAEAVRLALVLSNTPFEDDRVGFGDWGEMKPKTPYGCLPIMSVDDGPLRTQSMAMLRWVGSSCSETLYPRDKIFDIEEAIGLMEDLNKSWYPAFAIGMRPQNYGRPEGFGQTEEGKKIIKEMRETWFQNELPRFLTYIENKLEGNQWLAGGETPTIADCVAVPILRNFSRGHVDHVPATALDSHPKVVDYIKRFCAQPQLKGRYNNGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4U9</accession>
    <name>B7G4U9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181977.1">
        <property type="nucleotide sequence ID" value="XM_002181941.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr38066"/>
    <dbReference type="GeneID" id="7202748"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38066"/>
    <dbReference type="eggNOG" id="ENOG502TAG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247855_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4U9"/>
    <dbReference type="OrthoDB" id="49229at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1519" mass="171287" checksum="86414091C0615475" modified="2009-02-10" version="1">MTKKPSFSVDICATCITSKAPPLPLREELPSLGFEIVYNAGGLGAKASKHETKIALDQYRKQCQTKELKKRRFFPKSSRRIRETLLERKKIEHQLKIPHALSYAAYEHRLARLEEKSWTSTSTSFTPTTHASSHKSISLYKYKDGKKPFTKRCKGRWGISLRRRIGSNRKKDTKSLPSETSEFLQTSSIRDTIGKAAFGDFLVPVNSSSHEKENGVDCGMYTKRNPLKWKRAFDSESFDSHSNDSSISSNGDCSTNDIKLQFVASDEMEKKLPVFNTFNETEREGAAFANQGMNKDVSLIMAAGDSAKSSAKLYDDLEVEEAIAAAFKEFANPKLNSASISPIAAQSSNNPFNIHEAPAPWSGSTKYAIENQSAEANGISSKVEPQRPMEREPIRDRDKSHIKQQNWFWFAKHLFEDVAGDVVKASITSTPGFKIEAKSLEVADEPVVVEERRAEVKKSIAHLPAVTLSIKTKAGSEGLGDSGGPNQCNTRLPFLEMLTGLGSCMSDILGAVQETPELAHVKCQDDGRFPLHTLCNRDIIDRSSVAESPLAGVLLADILEYKEVLRNLLEAYPAAATVMDKTGDLPVHLLARTLMKWEAYWYTTVYAQAAKVFNPDGKDANAISSLYHTMSTCVELVLEPLVTKEDLCRQPGSVGRMFPLHIASIFTCSVESLQSLLEAYPNAAKKRCDLNTLNTFTPDDSFPLILHDSLSTDFPKWEVEIFKQNESYVAGLGCHKYGDDTERYLRRSDLLFAYNPTIEPYRLDGERIRRLERKIIFEAIQVVEGKEDCLSKAMQRIWVWLCTFKEHGSKRPTYSQSVKRIARMLTLRAVQYLASISTPHGKLVLDEATPECSRVIQLRLAESQPIDLWGKRVPQSRRLTKQNVRQFVKKIFNVEQQRFPTSFIVLPYRLQVNKDGFNSIGTPEAIEVADLFTSYMLRLTDPRALLHYLNVKSQKHYGEPLIQGSKTDEARQNFLDSIKRVEDNMLSLYKPGSSFLYLLDEGTGFPVVPGSTDEYPIILAEPMSIIPKIFPLMMPGLVMMRGEQYLITLSKVLLDSDVTMVPRNWLTTTDNIERRLLSAEVADLTDSEASTLGDRISQLSSSNKTRWEGIMSPKNGNTEWAAEMSILNTLMEVNDPSMKFAGLKVQRDDDSSLFWSVDSNNDCCNSTLALGALHIDDLSNKQKELAKKLERMRVDRKDSGPDFRYPRKNFVEPHNEMLNKPFWQRLANACDYVKYPDKAVDSERKKLPLKIAIDCKSKLDSEISSDDMKGEIRKKYSFLLSDLAVKDRDNKGQEAFCCRQRERGSSSERIWEDVTSELDRAGMFYEESAILHLKVGIAEEAKRSGLLAKRIASLQEGGAHVCFKAEALDTELPYHEIQNEVTVLPGLSDSRKLLIRLFDLEDRLLCDEIDIQHLAIESLSMFYQIEEVDPDNLFEETKEEFNSRESVLHRAHPRVHSASFRADARGFCGEKTPSLATSLSNDPGSFVNPLDLTNLNDNVMEDIAVPWVVYHESTGQIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G502</accession>
    <name>B7G502_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lhcr13</name>
        <name evidence="11" type="ORF">PHATRDRAFT_38121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182329.1">
        <property type="nucleotide sequence ID" value="XM_002182293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G502"/>
    <dbReference type="STRING" id="556484.B7G502"/>
    <dbReference type="PaxDb" id="2850-Phatr14442"/>
    <dbReference type="GeneID" id="7202961"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38121"/>
    <dbReference type="eggNOG" id="ENOG502S5AH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_3_2_1"/>
    <dbReference type="InParanoid" id="B7G502"/>
    <dbReference type="OMA" id="WIALFEM"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012971716" evidence="10">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="206" mass="22267" checksum="B8574EDE9FBABBF5" modified="2009-02-10" version="1">MKSIIFASLLTSAAAFAPASSSTTRTATPTALNEEFCRGYVGGESVEPMFIGKTGSKNFDPLGLTEKVPEWVPWFRESELKHGRAAMLAVAGFVVPEFVRVPGEAYSFAAIPNVIDAHDALPQAMIQIFAWISFVEAVSFPALANMNEFDRVPGDFGFDPLKLYPKDAAKQEQMQLKELKNGRLAMVAIGGMVTGSAITGHGFPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G525</accession>
    <name>B7G525_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182342.1">
        <property type="nucleotide sequence ID" value="XM_002182306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G525"/>
    <dbReference type="STRING" id="556484.B7G525"/>
    <dbReference type="PaxDb" id="2850-Phatr47831"/>
    <dbReference type="GeneID" id="7202971"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47831"/>
    <dbReference type="HOGENOM" id="CLU_938327_0_0_1"/>
    <dbReference type="InParanoid" id="B7G525"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855775" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="297" mass="31722" checksum="B28FCC7D2E7B7D7C" modified="2009-02-10" version="1">MTRGKTYGCGDRVMHIRLGLFLLLSLMFQYATAQQECSPACGPYGRCSNVVRTCTGRDCEKACRCKAGFAGADCSIPFTLCEDTVNPAGTATVCYNGGSCLEAGHYDGVTKEDVWWCDCSTAYTSTGTAFAGHQCEFPHGVSCETGLTESSYAFCVNGGSCLETIAPGSPHPGCRCVGQFEGRHCQYAAGTAPEKELTYTDATRAFTDGDDGISAGVVFILVALVLAVVAGAIFLVLRRGRRNASNKEMDTNNAPQLDDLQLTSFVEHKPEQVGMESMDAIPLEDVDVDGSERTEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G543</accession>
    <name>B7G543_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182182.1">
        <property type="nucleotide sequence ID" value="XM_002182146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G543"/>
    <dbReference type="STRING" id="556484.B7G543"/>
    <dbReference type="PaxDb" id="2850-Phatr47847"/>
    <dbReference type="GeneID" id="7203074"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47847"/>
    <dbReference type="HOGENOM" id="CLU_401424_0_0_1"/>
    <dbReference type="InParanoid" id="B7G543"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="206"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69396" checksum="3E81AAC382D15292" modified="2009-02-10" version="1">MGNNSSSSRTGIGLKLDQAGYQAGDVLKGRVYLALRQGDPVLRNLRAIHVLLQGAENVEIERHIRDGSGSSSKTKNVVVDRSTRVFVRTDLFLAHLPSAKSGAAKVGDSGAGQYEYPFQYRLPDNLPGTMHCSHKDCRSFAEVRYTLTAYLAMEMADQDDQPAVQASTAVYVKGRRPNEVFVDIPIQPLRAETEAFPVKTCCFWNKGVVHLGWQIPSPTPYPGETIPVRVWGNNQSSVDVQYLWVRCVETVHWKAADETVVAHRNTNGHIAGRPSQKSVRRVLAEQKIGVTRAQGLWQPVYETGRHRDSTLLQADDQTLLTAHLRLPKESRLSYAGRLVRVHHTLIVTAVTKGGCATSSPESACQIRILPAVDHQHQGPDAGDATISASMPLAAHATSPLNPTAPTANLVYGSDNTTYDDILQAQVLPDDWKPSTADEIILPEASAVFVDDGVSPASIPLAAGTNRAPSTATPINDTSGSLHVNVAAATAPEQHLLDDPEDVFSNFTETARRPFPTNAAVAELRRVVTVCPQNLPAILEDPSWATAVQNLSPRDLCTVLQSAVDPVAPRVARSLGTCMGSSLTCRHLLACLWSLPEGQRMDVVRELAPLASDLPEHQRLVEQELDRTELLNFRAALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G566</accession>
    <name>B7G566_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182193.1">
        <property type="nucleotide sequence ID" value="XM_002182157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G566"/>
    <dbReference type="PaxDb" id="2850-Phatr47865"/>
    <dbReference type="GeneID" id="7203086"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47865"/>
    <dbReference type="eggNOG" id="ENOG502S6ZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1664118_0_0_1"/>
    <dbReference type="InParanoid" id="B7G566"/>
    <dbReference type="OMA" id="GHSILEW"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="159" mass="17742" checksum="EA3369C9DB124D7E" modified="2009-02-10" version="1">MFRLVVSPARPKGRQSSLYGAAAFVLRPPTRWTTCRSLVQHTVPLRAVQYILTYEYVPDVLEKRGPFRDEHLRLARDYVTENRAVAGGPTGAVGTNVPTGALFLFTDRDAAREFVARDPYVAHGIVTAHTIQEWNVVVQKADDDDGDSKRVHSKQQGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5H7</accession>
    <name>B7G5H7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin extension protein 1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBI1/2</name>
        <name evidence="14" type="ORF">PHATRDRAFT_22043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182250.1">
        <property type="nucleotide sequence ID" value="XM_002182214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5H7"/>
    <dbReference type="FunCoup" id="B7G5H7">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G5H7"/>
    <dbReference type="GeneID" id="7203140"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22043"/>
    <dbReference type="InParanoid" id="B7G5H7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC46151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="128" mass="14454" checksum="3F83D3BD0998D471" modified="2009-02-10" version="1">MQIFVKTLTGKTITLDVEPSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGVYDPSLALLAKGFNCDKAVCRKCYARLPPRATNCRKKKCGHTSQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5N9</accession>
    <name>B7G5N9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_14571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182283.1">
        <property type="nucleotide sequence ID" value="XM_002182247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5N9"/>
    <dbReference type="STRING" id="556484.B7G5N9"/>
    <dbReference type="MEROPS" id="T01.A02"/>
    <dbReference type="PaxDb" id="2850-Phatr14571"/>
    <dbReference type="GeneID" id="7203009"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14571"/>
    <dbReference type="eggNOG" id="KOG0173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673488_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5N9"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="20737" checksum="09E2994737279A2F" modified="2009-02-10" version="1" fragment="single">MHQRLLKTGTTIAGVCGADFCVLGADTRATNDRLVADKACAKIHKLAANVYACGAGTSADLEHVTRQVYYTTLLQSRQDEAIGNAASVDGALASSSNILYDQGGSCQATLIVGGVYKSKAMLRAIHPHGSQDALAFTALGSGGMAAMGVLESSYRHDLTLEEAIELVTRAITAGIVNDLGSGSQVDLCIITAEGTDYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Y6</accession>
    <name>B7G5Y6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E2f-dp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DP1</name>
        <name evidence="10" type="ORF">PHATRDRAFT_14805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182629.1">
        <property type="nucleotide sequence ID" value="XM_002182593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Y6"/>
    <dbReference type="STRING" id="556484.B7G5Y6"/>
    <dbReference type="PaxDb" id="2850-Phatr14805"/>
    <dbReference type="GeneID" id="7203459"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14805"/>
    <dbReference type="eggNOG" id="KOG2829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_904516_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5Y6"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
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        <property type="entry name" value="Transcription factor Dp-1, a"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
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        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="182" mass="21263" checksum="6EA9C5DB0C0C1FD8" modified="2009-02-10" version="1" fragment="single">GLRHFSKMVCKKVEEKGSTSYKEVADELVDTVKKEFLKENPHGKFEEKNVRRRVYDVLNVFMAMDIISKDKKAIVWKGLPSSAHQDIEMLTRERDFRMQEIHRKREALQHLLTQQVCFRNLVQHNHARGLANDPNDHKIPLPFIVVNTHSSAVIQCNMSRELTDVMFDFSAPFEINDDNMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6B1</accession>
    <name>B7G6B1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182694.1">
        <property type="nucleotide sequence ID" value="XM_002182658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6B1"/>
    <dbReference type="STRING" id="556484.B7G6B1"/>
    <dbReference type="PaxDb" id="2850-Phatr48196"/>
    <dbReference type="GeneID" id="7203518"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48196"/>
    <dbReference type="eggNOG" id="ENOG502RW9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666424_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6B1"/>
    <dbReference type="OrthoDB" id="48536at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="253"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="405" mass="44841" checksum="E8EEB30C0DB5D997" modified="2009-02-10" version="1">MWHRLIPVKGTARLSALSYYNFAGTTTCPAFREAVVSGRISNAQKRMLSTSGGVDIAPDKAKGTYNKSAATLRFYRILQRQCKELHRSLLVSTNENSDTKSAKDSFVLIQQPIDPHHAGGSQILSNITDASPSAILRLFWYWNEDLEDDEFDAMADWLDGVNSTWNETQPELSLSSRYGDGGCKTLWASPEALRQTIRQVFRHAPTQTTDGVTEATPTYVPYRAAWSIRAYQYLNDLREMQRTTSVSNEKNVRIVATSRCVDVSGVVGMGRGNPTTATIPWRTRFAYRIRIENHGAHAIQVLGRTWLIQELLNDQPTGEPVRVHAPQTGAVGKLPVLHPGEAFEYMSGCELATTVGEMKGCFHCCVVEDGTPSAVVGQHVEAFQSDQRFEVTVQPFPLLADSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6E2</accession>
    <name>B7G6E2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_38628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182557.1">
        <property type="nucleotide sequence ID" value="XM_002182521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6E2"/>
    <dbReference type="PaxDb" id="2850-Phatr38628"/>
    <dbReference type="GeneID" id="7203342"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38628"/>
    <dbReference type="eggNOG" id="ENOG502SX2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1242212_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6E2"/>
    <dbReference type="OMA" id="KIDYLIW"/>
    <dbReference type="OrthoDB" id="40222at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="54"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="25819" checksum="61F19140E1608DEE" modified="2009-02-10" version="1">MSNPLFLGLYKFWSVYNGDTSFLPLYLPLLFWVVSYTYCRFVRREFHKWTLLHSFHNFGAIVLGLISLYYDNDAVFSERLSILWSMAYFLVDIVDCIVRGDVAYTVHATFCLLLGVANYTTPVCRELRMNSKAALLECSTPFLYVAKTTRHPAHFILFALAFTLCRIVWVPVLSLQLKQAGRGYTDYLQLALCGFYCLNLFWYAKILRILYDGATGKIDKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6F6</accession>
    <name>B7G6F6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_38642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182565.1">
        <property type="nucleotide sequence ID" value="XM_002182529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6F6"/>
    <dbReference type="STRING" id="556484.B7G6F6"/>
    <dbReference type="PaxDb" id="2850-Phatr38642"/>
    <dbReference type="GeneID" id="7203348"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38642"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="B7G6F6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="340"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="587" mass="64164" checksum="F3579C510B953086" modified="2009-02-10" version="1">MMGGKVVTIQVPYLFKHLVDDLPSGAAITSEGSATATEAATAMMAADPSASVAAGVPVFLLLGYGLSRIASSGLQEWRNAVFAHVAQDAIRNVGRSVFDHVHRLDMQFHLSRNTGQLSRVLDRGQRSISFTLNAMVFHIAPTILEVGIVTSLMGYQFGYAHSSVVMATVVAYTGFTLGVTSWRTKFRREMNRLENQASGRVVDSLLNYETVQYFNNAQYEGERYESSLKGYQKAALESQTSLSLLNFGQAAIFSAGLTSVMWLTSQQIVEGAATVGDLVLVNGLLFQLSVPLFFIGSVYREVRQSLVDMEAMFQLRDTIPAIVDKPNALSYDPSTMGTSIALHNVHFAYPTAANQRPILNGTTLDIAQGKTVAFVGSSGCGKSTILRLLYRFYHPDQGLISVGGHDIQDMTKYSLQRAIAVVPQDTVLFHESIAYNIQYGDLSASWDEVIEAAKKAKIHDTIMSFPDGYETVVGERGLKLSGGEKQRVAIARAILKNAPILLCDEPTSSLDSETETDIMSNLKDVGKGRTTLIIAHRLSTIQDCDEIIVMNRGMVVERGTHDELIAMGGRYTELIKMQEAVVDEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G850</accession>
    <name>B7G850_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_48717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183413.1">
        <property type="nucleotide sequence ID" value="XM_002183377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G850"/>
    <dbReference type="PaxDb" id="2850-Phatr48717"/>
    <dbReference type="GeneID" id="7195190"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48717"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400894_0_0_1"/>
    <dbReference type="InParanoid" id="B7G850"/>
    <dbReference type="OrthoDB" id="49134at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="272"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="687" mass="75708" checksum="D90120C5B430EDBE" modified="2009-02-10" version="1">MSESVWSKTILVALLRLFICLYVFPFLLVGVHLHAVASSHQTLFVYIQRKESGEAIGVDRETRKNIYGTSPSIGGDNGVDDAVITGVYDYVQEGLFVWRESQHIKSSSWTRFSWPDITSNRFTSPRDGFSITDISSVVSPTRLSRSRDSSEWCLYAGRDWKKVACHEGSAVVGEYIDTDTVSGAVDTSSQNDKIRIQIQYISSFDRWRHGSASSPFGYRTTIKLKPWQRMLLEKPATLFWMGINIGLAFVYWNRRIAVSSVAKVYSKMMHDGEIWRGLSGATAHFETWHLFFNMQALYSLGSELESNDGSTKYSSVTFFMYTASLVLWTTIFWLLLETLKRRFESAMSPVASGDSPTVGFSGVLFAWMVVASLEQSQTCPVHFLPSLCFVTHEFVGFRFNFAPLVQLGIAQVLLPRVSLTGHLAGILSGLALHWGLLPLAYTQPAVLLPTLYAMYLKFVCPTTQVFSTRLGSNDTSDRVARFSHQWGLKIVLAMSSWTFGVMNALTICFGLVVGYGHWNSGKLPKDIRVVKGWMITVVLACLLDAMSVAGWTLLVPGASRLPAAIAPTSVMVIRWVAFMTSLAGAACHLTPTGSTGDSGDEANTSGIFDMVLGWTVVQPATVLAHAWSRDRVLPTGVFAGPGQALGGVSCSTELASSTRPTRWGGQGYRLGAKVDDRNHDTELSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8B5</accession>
    <name>B7G8B5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183317.1">
        <property type="nucleotide sequence ID" value="XM_002183281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8B5"/>
    <dbReference type="STRING" id="556484.B7G8B5"/>
    <dbReference type="PaxDb" id="2850-Phatr48773"/>
    <dbReference type="GeneID" id="7195048"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48773"/>
    <dbReference type="HOGENOM" id="CLU_1630259_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8B5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="154" mass="17104" checksum="14D5593D0A5BEA44" modified="2009-02-10" version="1">MHSLSAIDEFDIRAAFEVLDDGVQGRISLEDLRTLYIGLGFEPMRMTLEELGGKLVANLVDVEKNGVSIDTALLVLSRYKRNRELNMQSTFDLIDSGGKGYLTKDDVQRLAQDVGEPVSQKRAKVLVSLCSLDGKIDIDDFNRLFSPPSPPVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G907</accession>
    <name>B7G907_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183558.1">
        <property type="nucleotide sequence ID" value="XM_002183522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G907"/>
    <dbReference type="PaxDb" id="2850-Phatr48957"/>
    <dbReference type="GeneID" id="7195239"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48957"/>
    <dbReference type="HOGENOM" id="CLU_1039988_0_0_1"/>
    <dbReference type="InParanoid" id="B7G907"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="29307" checksum="4A6711E4FC3CD463" modified="2009-02-10" version="1">MPKLALSRRHQRQRNLLEVPDTSESTFPNTPRKISEESIHHTISVASTSPVASIADDCSNSSCTSSVEFQQAPGDASDYCSDSASNSPPVLETESNLSRQSLKRPIHSVCLVDMMDTHDNDAWNHTPTAIPVSPSLGAKPVAAPEEPVSPLWGHFVELFNAPTRDNADESGEFGIHTPRFCHPQGKLQLVHSNSHYNSSNSTKHSRFMLGSASQGPYPLKRRRKMSGNAGSSLMDEFMLGGPTSFQSRNLKHSSSTQRIQDALQGLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G912</accession>
    <name>B7G912_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_39571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183561.1">
        <property type="nucleotide sequence ID" value="XM_002183525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G912"/>
    <dbReference type="PaxDb" id="2850-Phatr39571"/>
    <dbReference type="GeneID" id="7195241"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39571"/>
    <dbReference type="HOGENOM" id="CLU_718593_0_0_1"/>
    <dbReference type="InParanoid" id="B7G912"/>
    <dbReference type="OrthoDB" id="49043at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853095" evidence="3">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="404" mass="43272" checksum="E83FB984D71D49B8" modified="2009-02-10" version="1">MMRILLFAMILLDAASLAQPNDEAQIHKSVFEKRELMNNYIELSMSMPVIGKGKGKGKGKGIDYSLSSKSSKASWSKSSKSKGKGSSKKSDKSGKGGGKEISLVPTVPTPTTAPIVAPPTITTTSPFGSTMSESPNSTPAPTLTPVSISPFTILYTIEQFRLPLASEYVSVANLTANYLNEYFRANFQETSLVDFVIADTMMTDNNFQFGQPVEIDYRTQLTFASASFIPSTEEFDELLASAFRDDNLAIYISLLNSLPISNIFQTTSLVTFEGSTSATVPATSADSAARAAGIAVAAGAGALIFIIAGVVMYRRKEREEVGKRLDEDGQMTVAGDTCGGSSMDSQSVVNQTHAMNDADGSSVSELGDFQVAPSNHPILEEGAEEETDDECDFEERGQLSEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9E3</accession>
    <name>B7G9E3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183762.1">
        <property type="nucleotide sequence ID" value="XM_002183726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9E3"/>
    <dbReference type="STRING" id="556484.B7G9E3"/>
    <dbReference type="PaxDb" id="2850-Phatr49073"/>
    <dbReference type="GeneID" id="7195315"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49073"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452351_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9E3"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="647" mass="70659" checksum="2FC3C53B1D85A30F" modified="2009-02-10" version="1">MTRTAPPSPFFRPSTPHVVVVRQSPGGTRTTVSQKEVHEHKSTMLGCTANLVNAIVGSGIVGIPYAIQQAGFGAGLFLILLCAVITEKSLRLLISTAKHVHCPSYETAMEAPFGVAGFRFVAINMFVMAYGAMLSYLMIVKDSFSVMIGIETDDFPMKRAVLLLVSILIMVPLSSQRDMADLAWTSRLSVIIDTVLVGLVAWNAPIEESFQNRGGWPAVLIDTFHADTIFVGLGVLSFAFVCQHSAFIIAGSLDRPTVARWSIVTRNALILCACLATTCGVSGYLGYLDKTQGNILNNLSVDSFSANAARGMLGCTMLFVYPLESFVARHVCVVLLFSGRRAHEGEDSAILNRRDRRIGLTVLLYLIAVIPAAFFEDLGSVLAATGAVGGSCLSYIGPGLVYFGVHGGRFLELVDASWLGSVWRTNNKSTADRHTGQSSRPTLAVETTPLVAGQNDPPKQEKTSEPLVQESLLFSILKRIVWYILWMPFWCSIAKIGRRGLTSHIYDLALKSPHPIRIGEVEYHRVAVSRKGYIDADPEEAAVLRPSSQHAFDDAYLPMLAKEQQQRPKNSSMLNRPFVPSAGREGQGINQQIGKKLLEQQRQQETTVEPDPQEDPPTWVDFGIAIFLVLFGVLAMLAGLISLYIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9I9</accession>
    <name>B7G9I9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183782.1">
        <property type="nucleotide sequence ID" value="XM_002183746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9I9"/>
    <dbReference type="FunCoup" id="B7G9I9">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G9I9"/>
    <dbReference type="PaxDb" id="2850-Phatr15613"/>
    <dbReference type="GeneID" id="7195197"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15613"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094004_2_2_1"/>
    <dbReference type="InParanoid" id="B7G9I9"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="123" mass="14034" checksum="1AD28F1A54BF7B10" modified="2009-02-10" version="1" fragment="single">KLQQGEKLRYYIYKIEDKKTIVIEKKGARDRTYDDFVADLPENDCRYGLIDLEFKTDDGRPTAKLVFITWNPDTANVRSKMLYSGSKEALKTALNGVGIHINATDQAELDLETSILPTCRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9P0</accession>
    <name>B7G9P0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183925.1">
        <property type="nucleotide sequence ID" value="XM_002183889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9P0"/>
    <dbReference type="PaxDb" id="2850-Phatr49156"/>
    <dbReference type="GeneID" id="7195654"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49156"/>
    <dbReference type="HOGENOM" id="CLU_313205_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9P0"/>
    <dbReference type="OrthoDB" id="45468at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123568" checksum="9784745E9FD028B9" modified="2009-02-10" version="1">MDDSTGDGSSEGHDGDDKPRLNWTSAQEQLVGRESEWKRLHRALEEAVSGSARMRSNSHSETLPRRSCALKSPPIVFEGESGMGKTFLVTQFLVHVQEEHKHVLAGYGAFPFGRSDVPFAPFQSAMHDILSVLLREDREIWKTQYCFKIWMISIRADPYKPYLKRENSSRSTSMEEGLKWGFERLRLALRSLFRLITIHRPVVLILDDLQEAEIDAWSIITTLVHDSSLPGLLLVGTMIPKSLEIMNACSAVEIHTLAPWREIGTHAWLEALVQKASKEDLQALVKFVSGKAYGCPLSTIRLLRHLEYHDCFSYDTERRWTIQLPTYMGSGSTIFESVCRLPNAMMALTTAACLQTNIIDPDTLFYLLTAEEDEGDAYTSNSQIGVTHPMKCIGDLYTVLDHAVDAGLLIRRAQDSVTPLPSRGNSPPPRTLVIYRFANSSTRQAAYELVQTPDEWHLRIGRHLRDWMHQVAERGSRIEDSLHIQVVRQLTLGQPGILDSWELLDLSELNYQVAQRTAHKASFYASLSFLKDGIRLLGNDPWKHHFDLALEFSIAIARMYSACGRYQDAILSADQVIFRTNSIRHQRVAHMIKMSHIFFHEGRSTDAIDYTLDVLESLECPFPRRFHKVHIATNLLKVRKMLKSRADVELRNLPTATDPKVEYTADFLEKLGEYAYNARTPQPDCLTLVLLRHMLLTLDYGVLTQTAASFVVVGFIFCQIGEFDEGAKYADIGLEYAARGNGGRSDQRAIVLYHFFVAHWSSLYYHSIEPTTRAVLAMWEMGSVQTAIEDTIALLRLKYTAGQDLTKVSAAIANQDANLRDYQLVHLLDVNMSFFQMVSNFMGKSESPSVLSGEYMDQDKMVTKWTQQGNENALQALYFHQMELAYYFGDIKLAKKMLKKMWSPYTQGADIWVTVKVFYKGMVYVSLYASTGQKKYKVRGNAAIRQMKAWVEKGVVNCQHMLLLLRAEELTGPLSGCENDFDFTRRAFDDAISCARKHRFLQHQALGNELAAIHCIRQNEDSWAAAYLDSARKLYGEWGAAAKVEQMDHKYRRVFEGSTEMLDSDMNAFTSSFHSQRLHRNLRILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9S2</accession>
    <name>B7G9S2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCDC43 PWI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183826.1">
        <property type="nucleotide sequence ID" value="XM_002183790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9S2"/>
    <dbReference type="PaxDb" id="2850-Phatr49187"/>
    <dbReference type="GeneID" id="7195632"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49187"/>
    <dbReference type="eggNOG" id="ENOG502R8KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1291199_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9S2"/>
    <dbReference type="OMA" id="IEEAWRN"/>
    <dbReference type="OrthoDB" id="49156at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="214" mass="24672" checksum="7275B61543AD1314" modified="2009-02-10" version="1">MSEDEDKHVLAPFLTSRLPQLGLDYETYGPYVLPLLTDEEVDEDEWESVVELLQASSESHGDDEQAWKDLRVQIEEAWRNHKLALDEQEAEFKQNQATRLQEEIEREREIAVEAALMEKDRKEKPAVVEQDAARKALVARFAYDIPDEDDADNEGVLSNKEVAAQAKLEQTQGLRQQKVTTKREEQQKTAKARVDKANAKEERRARATKGERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9U6</accession>
    <name>B7G9U6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183837.1">
        <property type="nucleotide sequence ID" value="XM_002183801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9U6"/>
    <dbReference type="PaxDb" id="2850-Phatr39868"/>
    <dbReference type="GeneID" id="7195682"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39868"/>
    <dbReference type="eggNOG" id="ENOG502SF8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1091790_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9U6"/>
    <dbReference type="OrthoDB" id="49329at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855988" evidence="1">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="248" mass="27656" checksum="C51CC6CFA720148C" modified="2009-02-10" version="1">MDWIKFLFLLMASGWKRGNSWRLTSQSSNLSKIRPRSGTITPGILLYATLPKGYEEVGTRLIQEAGRQCGITDDNRLKAEWKAGRIIVTVYGDSYVSDPVDSDADFEEGDDYIDIDDREMEHLEVAVNAVASPPPGAVDVTQLTRAINAAFDADEVGLAIAEAHEVEVTTPGASDELSGIMFQSYRGFDVIVQHMDKNTKKQKIIEGRLHERNDEFTVINIKGRMKNLKNQDIISVKLPKAKREKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA29</accession>
    <name>B7GA29_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_49278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183997.1">
        <property type="nucleotide sequence ID" value="XM_002183961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA29"/>
    <dbReference type="STRING" id="556484.B7GA29"/>
    <dbReference type="PaxDb" id="2850-Phatr49278"/>
    <dbReference type="GeneID" id="7195568"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49278"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445173_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA29"/>
    <dbReference type="OMA" id="SFPIVTC"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="113"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="618" mass="67544" checksum="952B8169FC979EB0" modified="2009-02-10" version="1">MGLMAQSAMTDGGEDALVNSELMNEVQLQQVDNFAETAAGQDGKLPLRSLNTQHSFLSYIQKSPLLTKARIFQDKGSEPDYRSTHEPRHHVLLLREQQVSLELLKPDHSSQARKSSPMVAMINMVATVCGGGVLSLPLAFSKAGILPTTLLMIYGALTTDLSLYLLVACARRTGGRSYGDVAMAAFGSAAQVVTTVTLTTMLCGALIAYQVLVKDVWTPVLLTTVPGLSVSLGKLSDREASNLLLAGILLLAMPLLLKRDLHALRHTCYVGFGSCILLLVAVFFRAAQKIRHQSVHAAINWYSTDPADWLFCFPIVVLCFFCSYNILEVHAQLMHPTRLQIKRVIDHSMMICLVLFYTVGLCGYLYAGTATADNILLNFPFQDSAVLAGRIGFCFTLLFGLPLVLLPCREAALSIPAHWRAWRQDVAETRKFRLLARERNNYGAHLIVNGVDFDATEPHLVSKTRHGASLRYGTACIEQTLSADETDGTATNSANSSWTQLVNSDEQGMRTVDSCPNDCFLQSWKEQFSNVVPTVVILLVTYFVAISVPGVAAVWSICGSSMAIWIAFIVPTACYLKIREHKGLTLLASAAWLLLITSAIAMVLCTRQAVQNATSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAE5</accession>
    <name>B7GAE5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184181.1">
        <property type="nucleotide sequence ID" value="XM_002184145.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr49379"/>
    <dbReference type="GeneID" id="7195771"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49379"/>
    <dbReference type="eggNOG" id="ENOG502SP3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_12_1_1"/>
    <dbReference type="InParanoid" id="B7GAE5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151928" checksum="CED4149D3B596AB3" modified="2009-02-10" version="1">MRRPRKVTPAVPAPAAATDSPADAASASEEDEEFGGFDSSDGEEPSGTAPPSPASSDDEGDGKKTAKPLARSKNTSDEVSVIEKSVIDAEPHLSKDSDGLDSVPRQDRVERKALMVVLRDVICVPLSVAAAMLNNGIKSSDDFRLLTKEDINDLCMRLKMGSMHTKRILVFAKWMHHAPNSVDVAKEFTASVLRFEMMTRAAASYDNVTTTAAKAEKSATSLLPEPFDGSQKKWLTFRYGFEAWAGASGSTFTACIAHHSDRYSKADPTGPHTSPRDVSDLFALSPVVNITRNATIFYTLMSLTSAGDAWGLVEPHEHTKDGRSAWISLCAFYEGTSQVGLTTEQARATVMESVYTGLSKQFSFTKYVARHITANNALLRNKEGYSDAQKTNFFLKGITDPALLPYKATAEARLDDWNFNRVVNYMRTSATKLSSKDRSDSRNVRQTKTTGRATGNQRGNDNKRRGSSNRPSNKGAEKPSRPHKHVLPPELWEALTPAIRESILSAKRSIAPPGREAKRAKSSDTDNSSSTVESYSQLPSSKKTIRKHTCENHVQVDPSTPETLLRDAPTDISPHVTAKKVTFGAGVLFGRYANRVSLNRMVRSGSHFDQAPWRKSDFRLNDATLVRIRQNRSRGTKTPTNYGEAVIDTGADTVCVGAGYSVLSYTGRSVSLRGFHDDGETFERIPVVTAATAYDYDDGTTVILIFHEALNLGPTQTTSLINLNQIRHAGHQTDDIPKFLSQGKSLHGIETLDGDYIPFELKGRASLLYSRVPTQHELDNCQHIDLTCDQPWDPNSKDWEENEAKYTRHDRSRRACYTDSVQVDILPDWPPLPVSPGSVVPDFHNRVMNPRDVVRDIKYATIGASISSPRVMDVDRDTLRRILGHVPMEVVERTLTATTQLAERTGEMPLHRRYKTKFEQLRYRRLKCTLYSDTFKSSIKSSRGHTHTQGFVCGDSYFIYHYLMKAESAADQGLAEFIHNIGIPAQLHTDNAKVETLSKWKKLTSSHWIKTTVTEPYSPWQNRCEHEFGAARIHTRLVLETTKCPEQLWDYALAYVIFVRNHTARKALAWITPLTAMTGDTHDISEILVFEFFEPVQYFDNPDVKFPQNKAKVGRWLGIATNVGQALCYHILTAKGTVITRSTVTPLQNLDSSALQTALATFDATIREIYQPSDFALGNKIKAPAFRRDEAMKVARRSDDPGDGNTRNRHVLYDLNEGDDHIQLDPGLTVDDFFENDSPDQDPTSLIIGTDVLLTSGAVQRQGRVTKRDRDGTPVPNDDPGNFVVEFDDGTEEVHGYQALLDAVYKQIDDDGNEWYTFDDIVDHQKRPRGGRGRTRGWFLRVKWANGEQSLPGGQICGRPRSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAL2</accession>
    <name>B7GAL2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SMC2</name>
        <name evidence="15" type="ORF">PHATRDRAFT_30352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184096.1">
        <property type="nucleotide sequence ID" value="XM_002184060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAL2"/>
    <dbReference type="FunCoup" id="B7GAL2">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAL2"/>
    <dbReference type="PaxDb" id="2850-Phatr30352"/>
    <dbReference type="GeneID" id="7195804"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30352"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="B7GAL2"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="521"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1182"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="359"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="713"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="820"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1196"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1213" mass="134502" checksum="CB5C2A917C14AE42" modified="2009-02-10" version="1">MFIQEIVIDGFKSYARRTVVEGFDPHFNAITGLNGSGKSNILDAICFVLGITNLSQVRAGNLSELVYKQGQAGVNKATVTIIFNNEDESSSPVGYEQCPQVTVTRQVLIGGKSKYLINGRNAPANQVQNLFHSVQLNVNNPHFLIMQGRITKVLNMKPHEILGMVEEAAGTRMYETKRVGALKTIEKKQLKLDELNAVLAEEITPTLERLRGEKQSYLKWSKNNADMERIERFVIANEFMQAQKALDNNTEGSAEMEEQVAILDDKTSQIRELIVAKEREIEERSSSLKGEFENSHNEAKVLEEQRSKDLVKITSSWKNAKTNVTKAESDLDAARSLVTETKQAVVAKESDIATESQSIEHKILAAKEAEERLARLTLDYQNMSAGISSTEGDEGRTLPEQISKAHSDSKSAEAKVQQASMKMKHLSKELKLVEKDLQKEGKTAEKMAQKRAVAAHKVEDCRGKLKDMGFSPEEFNALDQEKTDLEITVSELSERVDTLSAQLEGRLRFKYSDPVRGFDRSKVKGLVAKLIEVKDHKNATALEVVAGGKLYQVVVDEAITGKALLDRGKLERRVTIIPLDKIKPRNVSHTASELANDISQSLDSRASPAIELVGFDEEVRSAVEYVFGSTIVVDGMKAANAICDATKTRTVTLEGDVYDPSGTISGGSNNQLGTTLVKLTELTQVTSKLDEKRSLLASISMKVKSMATHASSYDKLSATLELAEAELSNIDKHLSQTSFGMLVEQRDSMAAELEAAQNESIEMEEEKEKKWTLFVNLQAQEAELTERREQRLAEIDQAVKDAKADTVEKGRIARQADSKSQTFSLELDSLQAEVAAAEEAVSVAEQLLDEATGDESKVQMKVGEVRALYEEAKKELDELDGRLNLYSAKLVELKRAKSYLVKEAEVATLEAKKLSVTITRIHKERSGAEKLVATLMKKYAWIDSEKSAFGVPGGDYDFEETNPRHVGQQLQSLKAEQESLSKKINKKVMGMIEKAEGEYTELLRKRKVVENDKKKIQAVIEELDVKKKSELERTWVKVNRDFGSIFSTLLPGAFAKLEPPDGMKAWEGLEVKVAFGDVWKDSLSELSGGQRSLLALSLILSLLLFKPAPMYILDEVDAALDLSHTQNIGNMLKTHFSQSQFVVVSLKEGMFNNANVIFRTKFVDGISTVTRTIGIGSSRNRALAESDNADSTNTSEKGRTEQSRRIGKENTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAQ5</accession>
    <name>B7GAQ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184237.1">
        <property type="nucleotide sequence ID" value="XM_002184201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAQ5"/>
    <dbReference type="PaxDb" id="2850-Phatr49475"/>
    <dbReference type="GeneID" id="7195827"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49475"/>
    <dbReference type="HOGENOM" id="CLU_096662_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAQ5"/>
    <dbReference type="OrthoDB" id="197594at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="341" mass="38312" checksum="B5AC46CB509248D9" modified="2009-02-10" version="1">MKRYMFGKYRLRVPRFMEDERVHRYSVAYFVCGSLRSRHCYSSGRSEKGEYWFVGKQEARVFTTSSPERCLHGVVWSPLVKTQVLHTVTLLVSGVRDPSALYFILSQNCINALIACILPPALETTPPLYVGLINLGISPPQLFPFLAVHEPTNDHVHFPLSSVTLDTATSACAYAQSNAYVYFTCLNLIVDFLQNQYAPIREWIRGAEREQCLLASHLAALLRRMYQRIANLASGPVVDDVRSNAVVSQLTVNGLHEEIDALNDVFFCGIQGLNVRLCEDFLQTVVFVLFCLDCYHHKKAKSLMVGIVDANVIPEKEAQAQVTVSFSCEVVLTVRGNVLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAT6</accession>
    <name>B7GAT6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_15948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184249.1">
        <property type="nucleotide sequence ID" value="XM_002184213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAT6"/>
    <dbReference type="STRING" id="556484.B7GAT6"/>
    <dbReference type="PaxDb" id="2850-Phatr15948"/>
    <dbReference type="GeneID" id="7195726"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15948"/>
    <dbReference type="eggNOG" id="KOG3984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="InParanoid" id="B7GAT6"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="262" mass="27739" checksum="B2B85F3C7E321ECF" modified="2009-02-10" version="1" fragment="single">PTVGIICGSGLSGLAATLDGPTLTVPYADIPGFPAHCTVAGHKGEVVFGSIHGVQAICFRGRFHSYEGHDMKTVVLPVYVMRCLDTKIVIITNAAGGLNPDYNVGDVVAVSDHLALPQLAGKNPLIGPNDDELGPRFPATSDAYPDALRIAATHAAESLNMQEYWHPHGTYCFVSGPMYESKAECRLLRTLGGDAVGMSTIPEVVAAHHCELKVLCLSLITNKVVMEGDEGATVATHAEVLEAVQARSVQMQTLVKEIVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB06</accession>
    <name>B7GB06_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_16155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184286.1">
        <property type="nucleotide sequence ID" value="XM_002184250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB06"/>
    <dbReference type="STRING" id="556484.B7GB06"/>
    <dbReference type="PaxDb" id="2850-Phatr16155"/>
    <dbReference type="GeneID" id="7198222"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16155"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054987_2_1_1"/>
    <dbReference type="InParanoid" id="B7GB06"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="153" mass="16883" checksum="EED0ED523881D120" modified="2009-02-10" version="1" fragment="single">MANHKKRISGKSEGIGKPKMTKDERRAKYTQIARDRKAKQVAREKSIKLVCYNCRKLGHAVSECPEQKSQQKMQQSDVKICYKCGSHDHALAACPSMRAGGKKHDGTLPFATCFICHLTGHLASKCSQNEKGIYVNGGACKTCGSKQHRATDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBG7</accession>
    <name>B7GBG7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Methionine synthase</fullName>
            <ecNumber evidence="5 16">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">METH</name>
        <name evidence="26" type="ORF">PHATRDRAFT_23399</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16 17">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5 16"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184461.1">
        <property type="nucleotide sequence ID" value="XM_002184425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBG7"/>
    <dbReference type="STRING" id="556484.B7GBG7"/>
    <dbReference type="PaxDb" id="2850-Phatr23399"/>
    <dbReference type="GeneID" id="7198319"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23399"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GBG7"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00740">
        <property type="entry name" value="MeTr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.10:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000002">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.288.10">
        <property type="entry name" value="Cobalamin-dependent Methionine Synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="entry name" value="Vitamin B12-dependent methionine synthase, activation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007024">
        <property type="entry name" value="PRK09490.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="Methionine synthase activation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 16 17" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="15 16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 16 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 16 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="21">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="22">
        <location>
            <begin position="345"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="25">
        <location>
            <begin position="639"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="24">
        <location>
            <begin position="752"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="23">
        <location>
            <begin position="905"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="762"/>
            <end position="766"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="956"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="1207"/>
            <end position="1208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EEC44210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137880" checksum="36A6AF159FD29367" modified="2009-02-10" version="1">MGTMIQNYAKKNRLDEEEYRGERFRDWNCAVKGNNDMLSISQPHIIKGIYMQYLEEGGSNMIGTNTFSSTTIAMADYQMEAYAYELNYVGARLAREACDEVTAKDPSKPRFVVGAIGPTNRTCSISPSVEDPAARNVTFDELVETYLEQVVGLVDGGADVLMVETIFDTLNAKAALYAIGEFLEFSGLDIPVFVSGTLVDQSGRTLSGQTGEAFYVSIRHAKPMCVGLNCALGAKHMVPFVERLSKAAECFVHVYSNAGLPNAMGGYDDTPEDMARENEVFFENGWLNMVGGCCGSTPPHIKAIRETAERYQPRKLPDVGRPKMWLSGLEDLKVEDVHNQLGLPFLNVGERCNIAGSIKFKKLMMKGDYGAAMDIAKQQVEDGAHVIDINVDDGMLDGLAAMQKFVKIAVTEPEIAKVPFMLDASKFDIVMAGLKWCQGKCIVNSISLKVGEELFMEQATLLKKHGAAVVVMAFDEQGQAATEDEKIRICKRSYDVLVNKVGFPPEDIVFDPNVLTIGTGMEEHANYGVDFINSVKRIKEECPYVKISGGISNLSFGFRGVTKIRESIHAVFLHHAITESGMDVGIVNSHELLSVDDLEPDMKLLCENLVFNKTPDATDDMLERTNFERSKGGVVDEVKKSSWRDLEPSKRLEHSLVNGISEFVDSDVEEARVLATKPLDVIEGPLMDGMNVVGDLFGAGKMFLPQVIKSARVMKKAVAYLLPFMDAEKRENMIAAGLDPDDVDPDDDSNYAGKVLMATVKGDVHDIGKNIVAVVLGCNNYKVYDIGVMCSCEKILAKAKEYNVDVIGLSGLITPSLDEMVDVAKEMSKQGFKQPLLIGGATTSKMHTSVKIAPSYTTPEHPTIHVLDASRSVTVVNSLLGENKGEFVEDIMEEYEEMREDYYAGLEDRNFLTFEKAKEQKITINFDQSPVADTPNKIGITVIDTVKISAVVPYIDWNPFFQTWELRGRYPNRGYPKIFNDEAVGGEAKKLFHDAQTMLNQICEDGSMTLKGVVGIFPANRSEDGEDVHVYETEADRESGNVSTTFCMLRQQAEKESDDPYLSQADFVAPAGYKDHLGMFAVSCFGCDALVKKFESENDDYSKIMAQALADRFVEAFAEYVHREMRLDLWGYAAGEQLNESDLLKVKYDGIRPAPGYPSQPDHTEKRTMWNLLQAQELAGIELSESLSMMPASSVSALVFAHPESEYFAVGQVGKDQVTNYASRKQMDLALCERWLSPILNYERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBH6</accession>
    <name>B7GBH6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_7679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184371.1">
        <property type="nucleotide sequence ID" value="XM_002184335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBH6"/>
    <dbReference type="STRING" id="556484.B7GBH6"/>
    <dbReference type="PaxDb" id="2850-Phatr7679"/>
    <dbReference type="GeneID" id="7198172"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7679"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443118_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBH6"/>
    <dbReference type="OrthoDB" id="46524at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="105" mass="10760" checksum="DFAB60BD7084FEC4" modified="2009-02-10" version="1" fragment="single">VMGFGTTSFQGSISTTLQHVNSTAVSFATCARQYRGISNIDRDIMLCAGTQDNEGSCQGDSGGPLINANGVQVGIVSFGVGCGDSDFPGVYARTSGAADWISSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBK3</accession>
    <name>B7GBK3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184545.1">
        <property type="nucleotide sequence ID" value="XM_002184509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBK3"/>
    <dbReference type="PaxDb" id="2850-Phatr49816"/>
    <dbReference type="GeneID" id="7198477"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49816"/>
    <dbReference type="HOGENOM" id="CLU_1075453_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBK3"/>
    <dbReference type="OrthoDB" id="45960at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="259" mass="28854" checksum="236B1AAB0C693C06" modified="2009-02-10" version="1">MYVSDEKGSTCAAEREAYLLRNFDFECPGTRFLAVSLWDNGIGANMNYIAVPALMAGLVTNRVVLFVNKVPGKRKIMSTRWSLASCPRRDFQCFFKAASPYVPTVKELNEAYGLTRTEKQDLFHRGEVPIGHENDKVIYMMGLQKTPSMHLGGRLESTLYNISMSLIDSAATKVADPALLRSAADSITSQDGNRPGYHFQFSTSKIHHGLLFYALRPSLLSKHRINSILNQVVPANFDPAKSIGLPIRGGLFFKKIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC36</accession>
    <name>B7GC36_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PHATRDRAFT_23552</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="28">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184735.1">
        <property type="nucleotide sequence ID" value="XM_002184699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC36"/>
    <dbReference type="STRING" id="556484.B7GC36"/>
    <dbReference type="PaxDb" id="2850-Phatr23552"/>
    <dbReference type="GeneID" id="7198495"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23552"/>
    <dbReference type="eggNOG" id="ENOG502QQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232892_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC36"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="56"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="195"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EEC43794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1060" mass="110352" checksum="62D4B5C4C6556045" modified="2009-02-10" version="1">MTSRLLRAVTLSPPTWQRSYRVVRHFTSSSVYGQKSSTPVDDTPPLGVAYNSLTVGIPKETYALEKRVAATPESVARLVAPGFSVVVEEGAGRNSFFSNADYEAAGAKIVPNIWTESDIVLKVRRTNQATLLGNKTLISFVYPKQNEALVNQLASQQATVLAMDCIPRTLSRGQTYDALSSQANISGYRAVLEASNEFGRFFAGQMTAAGKVPPAKVLVIGTGVAGLAAIQTAKNMGAVVRAFDVRPVTKEQVEAMGAQFLEVDYSEDGSAAGGYAKEMSKEWHAAARAMLTKQCADVDIVITTALIPGRQAPIMVTKEMVAQMKNGSVTVDLAAEAGGNVETTVKDKKFVTENGVTCLGYTDLPSRLPTTSSSLYSNNISKLLLSAGPQTTKKPGFFYLDHNDDAVRGMLVLEKGKMMYPAPLPPAPAAPAKEKKDAAPVVIDYKAPFLQGAKTAGILSTSILAFGAVAPNPAFSSMFTTFALSNVIGVQVVMGVTHSLHSPLMAVTNAISGTTALGGMHLYAHSTSVAATLLGAAATTLSTVNIVGGFIVTTKMLDMFKRPDDPPEYYHLYGIPAATTMGLYGIGTMTGKFPELDASAATLSGLLCIGGIAGLASQKTARLGAVSGQSGVALGVASTMGHLNPTIGTAAGITALMGVGAVAGKYIGDRVEPTSLPQTVAAFHSLVGLAASAAAVGDYWNCPDTTQLDGVHLASIYLATVIGSVTATGSLVAFGKLDGRLGSAPLKLAQRDKINAGLGAATLGAGAVVMGAPEVGTGMAALSSALTTSGVLGWHMTASIGGADMPVVITVLNSYSGWALCAEGFMLDMPILTTVGALIGCSGAALTKIMCDAMNRDILSVILGGYGTKATAGGEAMHFEGEATMTNVDDTVRLLTESEKIIVVPGYGLAVAHAQYPLKEMVDVLIKAGKKVRFAIHPVAGRMPGQLNVLLAEAGVPYDIVEEMEEINDDFKDTDVTLVIGANDTVNSAAEDDPNSQIAGMPVLRVWNSNQVIVMKRSLAAGYAGVDNPVFIKDNTDMLLGDAKDTVEKLAVGVKTFYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC67</accession>
    <name>B7GC67_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184666.1">
        <property type="nucleotide sequence ID" value="XM_002184630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC67"/>
    <dbReference type="SMR" id="B7GC67"/>
    <dbReference type="STRING" id="556484.B7GC67"/>
    <dbReference type="PaxDb" id="2850-Phatr49881"/>
    <dbReference type="GeneID" id="7198512"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49881"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649683_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC67"/>
    <dbReference type="OMA" id="WVEKAMI"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856013" description="Kelch repeat protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45462" checksum="1C3EBCED0ADC0374" modified="2009-02-10" version="1">MRLAVVSATGTLGFCRLFLGILQAAILASLTFAHADDIGDNSIFQSTMLEAQLPKPLSDMTATYLGSSDDGVYIAGGCDDPNGNVFVDDPDFPGFSCGSISDTLYRFDVSESTIREVAKMPRPRYRHAAFGIQGRLWLVGGRDLNDDIVVEVDSYDTATDTWTTFTDLPVSLATSDVGGFSHGDYGYIVGGYSQDYKAQATTWRLLTTAALVNNSLANDDAVEIVNGLAEARGDVAAAFDNNFGYVSGGFTDVNKFCEPLASVSAYSFDSGEWSSLPDLAFARGDKGLAAFDGHIYALGGERQIENICAVTADTPDPGDLTVAVDVAERFDLGEGNTEWTLLDDLPIHRFRFAAVAVPARHEVLTFGGQQAYNADCQCLAATTDIVQYKEVPQESGTSDAGHGYWLLPMKMIVFAITYMTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCI9</accession>
    <name>B7GCI9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184881.1">
        <property type="nucleotide sequence ID" value="XM_002184845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCI9"/>
    <dbReference type="PaxDb" id="2850-Phatr49988"/>
    <dbReference type="GeneID" id="7198772"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49988"/>
    <dbReference type="eggNOG" id="KOG2860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606187_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCI9"/>
    <dbReference type="OrthoDB" id="45039at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="452" mass="50265" checksum="3D789BA8EBC2DA42" modified="2009-02-10" version="1">MGKNQFVRGYLSYVPIAVCALYLVASPAKLVAAHSQWKVQNRHRQTKLYESSKSPAARSVIADLRGGSQPRHSSADVREINSTLDFTNPSLIEEGPHLNALDSQSEADRLRNLDLNTSAALPIPAWREHLPPPLRLKKNTLQRVRIKNVEIFLLGTAHVSSDSSEEVKLLLRHVHPDAIFVELCEARIPLLEGTAKDEHEEEALAHQNRTMREKIRQVQSTQGGSRLQALSTVLLTSVQEDYASELGVELGGEFRAAYQYWQAQQSIPTGTSSQSCALILGDRPLQLTLVRAWESLGFWPKVKVLLGLLWSSWQKPKKEEIQEWLQSVLRDETDVLTESLKELRRHFPTLFTVIIAERDAWLAAKLVQSCRVLSASATAASPVCTVVAIVGAGHIPGIVAWLTTPPADTSITPETVLRDLVTTKRWAHDDAIQLQAIPAWIYEVSHLQPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCP2</accession>
    <name>B7GCP2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_16490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184913.1">
        <property type="nucleotide sequence ID" value="XM_002184877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCP2"/>
    <dbReference type="FunCoup" id="B7GCP2">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCP2"/>
    <dbReference type="PaxDb" id="2850-Phatr16490"/>
    <dbReference type="GeneID" id="7198727"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16490"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_2_1"/>
    <dbReference type="InParanoid" id="B7GCP2"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="31472" checksum="B4EB0908846FE16F" modified="2009-02-10" version="1" fragment="single">EFIPLRLLRKDILSHDTRRFTFALPNPKAVLGLPTGQHVVLKCTHPDTGKPVQRSYTPVTDNRVLGEMALVIKVYRPNDVFPQGGTMSQHVDDLRIGDAVLVKGPKGHLNFYDPTVAAFTVKPLGKPLESRTARNICLLAGGTGLTPCLQILHAIFRHENNDNSHVSCKMIYANQTPDDILCREELETLARAFPTRFQVWYTVDRTTTAMPTSNGSTKEAEETWAYDVGFLNKKMIEKHGLFPGQESSTQFFMCGPPPMIKFACLPALQELGFSEKDWVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCR5</accession>
    <name>B7GCR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_50049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184928.1">
        <property type="nucleotide sequence ID" value="XM_002184892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCR5"/>
    <dbReference type="STRING" id="556484.B7GCR5"/>
    <dbReference type="PaxDb" id="2850-Phatr50049"/>
    <dbReference type="GeneID" id="7198801"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50049"/>
    <dbReference type="eggNOG" id="KOG0403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025354_2_0_1"/>
    <dbReference type="InParanoid" id="B7GCR5"/>
    <dbReference type="OMA" id="NQDDCEF"/>
    <dbReference type="OrthoDB" id="414546at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="160"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="319"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="456" mass="50351" checksum="11B3CDD53BBEF48B" modified="2009-02-10" version="1">MVDFAKRPEVTVSTMGKLHNPTGEGVRAISNEAKVKAAKHSAAVASGITRTEAESAHDTKVGKEGTAKRNIIRKKTADIDSGNYNSTHKKQGGHGKGQWKDAMDPTYVEDVPIDEKDPLYNAAEDLNRYILSSHVDGSDHRGYDPQTSKSVYGPMLTNQEFKVQVAEALKEYFDSCDADEVIRTLEELGCQEFHHEIVKKAISLAMDNSSRERELTSRLLTCLHPTPLSMEHMEAGFNLLLDSVDDLSTDVPEAETMVASFLARAVVDEVLPPAYLSEQNNVRVGDMVIAKAVALLSREHCTARLERVWGPGDGRPVEELKIEMDQLLQEYLHSRELDEAARCVKELHAPHFHHELVKRGAFAAMELDGKKEEQDHANLDAMAALLAFLVKNAIVSEYQVKKGLSRLKDVLPDMQLDVPLAPALMEAFAGFCAEQGCLPVEKKVAAEVEEGTDQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCW1</accession>
    <name>B7GCW1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">20 kDa chaperonin, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Chaperonin 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein Cpn21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_16537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184950.1">
        <property type="nucleotide sequence ID" value="XM_002184914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCW1"/>
    <dbReference type="STRING" id="556484.B7GCW1"/>
    <dbReference type="PaxDb" id="2850-Phatr16537"/>
    <dbReference type="GeneID" id="7198764"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16537"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086520_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCW1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000001">
        <property type="entry name" value="10 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF63">
        <property type="entry name" value="20 KDA CHAPERONIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="90" mass="9632" checksum="4D3C02AAA2E946DE" modified="2009-02-10" version="1" fragment="single">LTPLGNLVLVRVKDTLTATGGGILLPDQSKERPTEGVVVEAGPGKIHPLTGVRIENPIKPGVSVLYGKFDGRPLEYQGDECQVIRDDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD36</accession>
    <name>B7GD36_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184980.1">
        <property type="nucleotide sequence ID" value="XM_002184944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD36"/>
    <dbReference type="PaxDb" id="2850-Phatr50142"/>
    <dbReference type="GeneID" id="7198937"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50142"/>
    <dbReference type="HOGENOM" id="CLU_331910_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD36"/>
    <dbReference type="OrthoDB" id="10405286at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="121" mass="13180" checksum="056E6554054983DD" modified="2009-02-10" version="1" fragment="single">MDLMNEVRVQRSFYETVVPEDMRVPLRLRVAGGLDWDCILHVLPPGTSWQGRWTTGSWAMIKTLTGVAEIASLVGPDRNGNLRKRTSKDLRGGSDGSLGGGQSTAGDKCIKYVGGPLRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDA3</accession>
    <name>B7GDA3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_41098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185092.1">
        <property type="nucleotide sequence ID" value="XM_002185056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDA3"/>
    <dbReference type="PaxDb" id="2850-Phatr41098"/>
    <dbReference type="GeneID" id="7198893"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41098"/>
    <dbReference type="HOGENOM" id="CLU_1216799_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDA3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="228" mass="25810" checksum="B02ADE07AEAFCC3E" modified="2009-02-10" version="1">MNHYTNNNLRKVYHDPRTDRFAVVVPLRPRSLLDLFEACCHRPSVGSEVGIDKTKNRCVRSRDQELTSSGEFKHQQSMGGVALEVPKAAVDNSKGPLLGSLLLDQLLGRPSHSVGAAEHGNQSDQSNTFFIRRKLLRRRHLHKIQKEREERATTAASASVQIQHPRPIYAHSSYQPAFYRGMPQYHHFMEVPQITIQADCMRMPCISPVQISNKRRKIGVVEAIPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE15</accession>
    <name>B7GE15_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_16904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185356.1">
        <property type="nucleotide sequence ID" value="XM_002185320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE15"/>
    <dbReference type="STRING" id="556484.B7GE15"/>
    <dbReference type="PaxDb" id="2850-Phatr16904"/>
    <dbReference type="GeneID" id="7199218"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16904"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1130912_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE15"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="73" mass="8566" checksum="7DEE0C856FC0929F" modified="2009-02-10" version="1" fragment="single">MAKADFYRVLQVAPHATMADIKTNYRRLVLQLHPDRLKHVPEAERLLKTVEFKKVTEAYAVLSDTTQRHAYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE59</accession>
    <name>B7GE59_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185380.1">
        <property type="nucleotide sequence ID" value="XM_002185344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE59"/>
    <dbReference type="PaxDb" id="2850-Phatr50451"/>
    <dbReference type="GeneID" id="7199261"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50451"/>
    <dbReference type="eggNOG" id="ENOG502SAGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383808_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE59"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="688" mass="74689" checksum="D3AF086ABF4B76B2" modified="2009-02-10" version="1">MPVATRTIIRAGAQEVEATRFDSFESTIPNIRVDNISNLDVLTTEAPPTSCTRLANAADDSDTRPGDEGSSLAGQVGSGPNWIERSFPVDVLGTSNVDPKKVDDYNLGICGQSYQVGPLGARMYEAITRNVNSSVQLATPEITKAYKVYAMDFTAKEAVRAALKQNGLEMVLTEEEEDEGMWADIDSIRLLTTNEDGSVTVTGPLYDSWQDAVDVWKPGQAFHFVARQVPAKMRELELDELLQALDPKGELRAQAKEAGMALPGEDIDSLAVLASDNVRRVETAPRDAVPVADAYAGTDEKRGYRVVYASDLLQDSMNADGTEQRKTLMHVMEALVAHGCVIVDLTDGGLALQKAFEMAQMWDTAQTFFGQPDKTSLPGMETVQETGSTHAKAGYASYDDGNLQFLETRYDREGNLLPEGARALLGPQGCAALRKAFHIVTNVAKDVTRIAVSASSVEYQALDGVAASAAAIQLTDELLDDGEPLTANIPHSEGSVSMSPHRLCRYSNNGSNSKEKSDDQSDTVDAKTKEVFGAHTDSTFVTAVPVAAVAGLEVYDEDAEQWYRPELAALRHWQGLQKGLGLDVNELVETIDGQQLPWFARYVVLMPGELLQIATRNEILAAVHRVVATEETSSRLSAPILLRGRPGTTWDVSRYLGGALDNPLLEEIDGMTIEQIHDAMQPKSSSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEA9</accession>
    <name>B7GEA9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_16982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185453.1">
        <property type="nucleotide sequence ID" value="XM_002185417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEA9"/>
    <dbReference type="STRING" id="556484.B7GEA9"/>
    <dbReference type="PaxDb" id="2850-Phatr16982"/>
    <dbReference type="GeneID" id="7199333"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16982"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_4_1"/>
    <dbReference type="InParanoid" id="B7GEA9"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd10292">
        <property type="entry name" value="GST_C_YghU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008731">
        <property type="entry name" value="PRK11752.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33001" checksum="DC07638D19CF4237" modified="2009-02-10" version="1">MSSSTSNEEYTPPKVWKYESSEGSKFSMNRPTAGPRFEKELPVGKHPIQLHSMATPNGQKVTIMLEELLAAGHDAEYDAYPIKIMEEDQFGSGFVAINPNSKIPAMSVSQEGKEPLRIFESGSILLYLAERFNAFLPADKRTETLNWLFWQMGSAPYVGGGFGHFYQYANVKNKYAIDRFTMETKRQLDVLNRQLEQNKYMVGDEYTIADIAIYPWYGWLVLGQGYGDAATFLNVEEDYPHVIRWAKMIEARPAVQRGSIVNKFWGDNEDAQLLERHSADDFQKTTAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEN6</accession>
    <name>B7GEN6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_41606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185579.1">
        <property type="nucleotide sequence ID" value="XM_002185543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEN6"/>
    <dbReference type="PaxDb" id="2850-Phatr41606"/>
    <dbReference type="GeneID" id="7199426"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41606"/>
    <dbReference type="eggNOG" id="ENOG502S7I0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1317694_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEN6"/>
    <dbReference type="OMA" id="NEYNACL"/>
    <dbReference type="OrthoDB" id="44284at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="209" mass="22415" checksum="9A1AEB59020140D1" modified="2009-02-10" version="1">MSCAFALCAWAFRWASPRSGLGVSAWAPPRPYDVVVRPETPSRRTFLFTPVVLLLASTGGTTGAAAVPLPPSVAERTALLEQARTQLVKVPALLREEKWDAVRAVLLQPPVADLWAKASGVKNILPAYAAAVGDAGGDELAVLEAKEDIVSHLRYLDMAVYNNVFNPIAVEGTVGATKALLRSYYEDPINEYNACLRALDELIALGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Q9</accession>
    <name>B7S3Q9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_bd1590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999265">
        <property type="protein sequence ID" value="EEC42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176199.1">
        <property type="nucleotide sequence ID" value="XM_002176163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Q9"/>
    <dbReference type="STRING" id="556484.B7S3Q9"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1590"/>
    <dbReference type="GeneID" id="7205032"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1590"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238525_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3Q9"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="927"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="958" mass="104691" checksum="3A024047787EF011" modified="2009-02-10" version="1">MTDVHVPKNSRIVQASYLEKHSSKVLQEDESIEPDGDEFPGLAATCHVLSQTFLEHVDKQVRLYTVQCCMELFAIYAPEAPWDTPEILAIFRQTIRQLANLAHTTASQPLFANYMNILDLLANVKIGVVLVELCKTAHPADDDEAALEVLAELVRTLLHSIRVEHPPQVSEYVVAIVNGIIDEYEKGVHIPVAILDELLACIGQGPTVSITKLQQNVPTPGTQPNPSYLTAATIVRVTSNKIATPLENLLNGLLNRQSHVVEASSISAEPPPTDSHDKVPDVYTIVYELHKVAPTCLATVLGTVTNGLTHEDTVRRTATVQLLGRIFVATPVVAKTHHASFGAWLGRSVDAEVPIRKTMVALLRQLVLTDASAPDVPDDIRQQAVPALCTLIQDVDVLVRLDAIQAVCDGAYHETARHGPASLLHAVGQRVSSKHKQERRNAVTGLAQLYFSRFLRPALVHVHNGGDDVELDVIRQTLHHGCRLDRPLTRKGRKTNTFPDADAVDVEDECYRWIPRKVMEALCFTDQTDSEMRSRVSLILDEVLLGSDLSSKSSKRLTSTARAVGLVMIVDSIRDGPTVAEASTSTPEKFLRQWLAARATLQKALRRYLDARATKRQHPHGTEEALTADAKAVELLETVASLTAVPSKSLPDVLEAFHGIRDKHVFNILATITDPTHSPKARARALEDLPKRTKSLGDAVSLWVKNLARRCVMGDFVNAEIVNHCVLLAQECFAEGDIAACTALLSPVKLVADIFPALCAVPKTFTTLTEVFSECRNATGAEAKREIQETSIITTLSSIMSAAAATDARSFKHAETHASSDDEDFRKELMLLCTRDGTPEQARNAVYTLAQLLRKESDDTKGFEPLLKALTSTTRMTVSGKESVKLVSVLSALAAFTDCAPALLEGTEKGNKAINFALECVLMGRRQDGGDEGYDSADEDGETRTPSPSSQDHHADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3S7</accession>
    <name>B7S3S7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PtRabX1</name>
        <name evidence="7" type="ORF">PHATRDRAFT_bd853</name>
        <name evidence="6" type="ORF">PHATRDRAFT_bd998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999277">
        <property type="protein sequence ID" value="EEC42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS999270">
        <property type="protein sequence ID" value="EEC42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176219.1">
        <property type="nucleotide sequence ID" value="XM_002176183.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176248.1">
        <property type="nucleotide sequence ID" value="XM_002176212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3S7"/>
    <dbReference type="SMR" id="B7S3S7"/>
    <dbReference type="STRING" id="556484.B7S3S7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft853"/>
    <dbReference type="GeneID" id="7204873"/>
    <dbReference type="GeneID" id="7205095"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd853"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd998"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="B7S3S7"/>
    <dbReference type="OMA" id="TIGIEFH"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002139">
        <property type="entry name" value="GTP-binding protein YPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25383" checksum="7CA123C16B4DDE78" modified="2009-02-10" version="1">MENNGGQPRPLQLGAKGAYIVRLLMVGDSACGKTSLVLRFDQNVFSTKFVTTIGVDYRDKMVKIEGAQMRLQLWDTAGQERFRSLTSNFFGRADGFVLTYDISNRPSFDHVIGWMRDIKTRAPPDCDIVLCGNKSDLDNDRVVTYDEGKLLADEYGVQFFETSALTGHNVERTFTALATTIKHKRIDEFEGTPSIRGAPSTDSASAAGDHRTVNLSSAGEKREGQKPGCC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0D8</accession>
    <name>RPOC1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PEP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Plastid-encoded RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNA polymerase subunit beta'</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC1</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 Zn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874413.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0D8"/>
    <dbReference type="SMR" id="A0T0D8"/>
    <dbReference type="FunCoup" id="A0T0D8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.A0T0D8"/>
    <dbReference type="GeneID" id="4524588"/>
    <dbReference type="InParanoid" id="A0T0D8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01323">
        <property type="entry name" value="RNApol_bact_RpoC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034678">
        <property type="entry name" value="RNApol_RpoC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF54">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000277182" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01323"/>
        </source>
    </evidence>
    <sequence length="696" mass="80750" checksum="FD1E500B87ABFFD2" modified="2007-01-09" version="1">MVESTKEFDYIKIKLASPFRILQWANRKLPNGQFVGEVQKSETINYRTFKPEMDGLFCERIFGPSKSLECACGKYKRVRYEGLICERCGVELTESRVRRHRMGYINLIYPVTHVWYINSRPNFMALLLEVEEFEKKLDTTYTTHSENCKKCDGLKLTTSTVVDLWDERVKRIKLASLAYFIAEDEISFYGIHWDLQQYRRSRELGYTGYPLKPYPKPQNRRYSTPKYLLRATPNFLIGAPLIKRELEKLNLKSEIFRMRYFILVCTKVLNKEKPIYDESRWFRKWEQQRIYKIREQAIKRIRILENLVGTGSSPAWMILTILPVIPPALRPMIQLEGGRFATSDLNELYRRIITRNNRLLRLLEIDAPQLIIRNEKRLLQEAVDTLIDNGKRGKIALSANNRPLKSLSDIIKGKHGRFRQNLLGKRVDYSGRSVIVVGPSLRLNQCGLPYEMAIELFQPFIIRELINQGLASNMKIAKNLIQQNESIIDPVLEKVLKSHPIFLNRAPTLHRLGIQAFEPILVQGRAIKLHPLVCSAFNADFDGDQMAVHIPLSLEAQAECYMLMLAPYNFLSPANGEPIIMPSQDMVLGCYYLTVNNINGLLGSSHYFANLADVILAYSQSKLEIHSAIWIRLEEQEINESILLKTTILDDETKIEFYENLQIRKTKDNQLIVQYVQTTTGRAILNYIIQKTLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y463</accession>
    <name>B5Y463_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_36970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185950.1">
        <property type="nucleotide sequence ID" value="XM_002185914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y463"/>
    <dbReference type="STRING" id="556484.B5Y463"/>
    <dbReference type="PaxDb" id="2850-Phatr36970"/>
    <dbReference type="GeneID" id="7204450"/>
    <dbReference type="KEGG" id="pti:PHATR_36970"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309399_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y463"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
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        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46218" checksum="928F145E3D8BD354" modified="2008-11-25" version="1">MASLISTYGSLRRFEDARRVFLTIEGPVDAACLRAILFACSTASPPQWNEALVLLHTCDVIGGTRSPTHMDSIAVSNAMLACSKADQWEESLQLLRLYGDNATSPLALNSLIASCGRGGRPDMAIEVLNEMRVYGLQPDTVSYRNAVIACNQAEHEMHRAARNHREVRLAQDEVGFAWWECALSLLRRMQEEGQQPDTQTFSSAISACESAGQWQRALRVLQSTLDDGDDSKLNLYCFNAAIAACEKGGAWVEALEIYERMKAHGGSLRPNFVTIASLVLALDRGGQKELAQEVYREGAQQLRVVQPWRYTQNAQEERVRAMDLHTFSAAMSRAALRSYLERLLAKETVVPADDWIIIVGQGRHSVEEPVLLPTVWRLLQYEYKLPVTTNPVNPGRLVVQSRDLSVLVKTKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4F3</accession>
    <name>B5Y4F3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">APC11</name>
        <name evidence="11" type="ORF">PHATR_10271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186283.1">
        <property type="nucleotide sequence ID" value="XM_002186247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4F3"/>
    <dbReference type="FunCoup" id="B5Y4F3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y4F3"/>
    <dbReference type="PaxDb" id="2850-Phatr10271"/>
    <dbReference type="GeneID" id="7203954"/>
    <dbReference type="KEGG" id="pti:PHATR_10271"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115512_0_1_1"/>
    <dbReference type="InParanoid" id="B5Y4F3"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000552">
        <property type="entry name" value="Anaphase promoting complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="82" mass="9474" checksum="9ED8A8B839A13519" modified="2008-11-25" version="1" fragment="single">LRVRIQRYHGVAQWSWNANDEVCGICQTAFEGTAPNIKYPGEDCPVVWGKCGHAYHLQCLTTWLQQPTSKNSCPMCRQEWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y576</accession>
    <name>B5Y576_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_44054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186137.1">
        <property type="nucleotide sequence ID" value="XM_002186101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y576"/>
    <dbReference type="PaxDb" id="2850-Phatr44054"/>
    <dbReference type="GeneID" id="7204008"/>
    <dbReference type="KEGG" id="pti:PHATR_44054"/>
    <dbReference type="eggNOG" id="ENOG502QWSX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520233_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y576"/>
    <dbReference type="OrthoDB" id="185024at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="548" mass="58538" checksum="7205A5F78D1AC6DA" modified="2008-11-25" version="1">MSTTTTDALNAAVAAMNQGRVFDVTIVCTTDDHQAAYWMDRLAAGVCRRPDQSATSASNPYPMVLAVSEDWNAPGGAGNGLGTLYAFEKANALAQQHYSVNLAGALAAGEISAALYHTAGKGTRLAPLPASENNNKPGVKLPFGLQLSDGSYQPLTVLEAVVKQTGIYAKARKGRLSVYWGDQVFLPSQPFDSAPTHHIDIMCTLLGDQAPTAEEWTAQGLEKYGVIACIQTAENRVDAAQVEKVSHATATAMLDKLGKIRQVGPSLGSFSVSAMILQALCAEFTPELAEKTGKLDTDPHFWMPLTLSSEDYLALMEQKGTDNVTAKAHYDRMAAMKDKLDLGDKMGLFGAVDVGKDACWWDYGLVKLYSKNTLVLLEDSPSATLLKKFLGLAPDAHVIDSTVREEVALDANSFVFGSKVAAGSIQNSLLASSQAAEITADGAIIVNCVARKITAGPGAILYNIMDQSEAGIVAGAGDIQVAVTDETGHAKILKSRMDVDGGQAWKIQLPQNDVTFEQVHQQNQNANIQVIQALRQAKFEEIAQTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5J6</accession>
    <name>B5Y5J6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UGDH1</name>
        <name evidence="12" type="ORF">PHATR_18745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186195.1">
        <property type="nucleotide sequence ID" value="XM_002186159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5J6"/>
    <dbReference type="SMR" id="B5Y5J6"/>
    <dbReference type="STRING" id="556484.B5Y5J6"/>
    <dbReference type="PaxDb" id="2850-Phatr18745"/>
    <dbReference type="GeneID" id="7203905"/>
    <dbReference type="KEGG" id="pti:PHATR_18745"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_7_0_1"/>
    <dbReference type="InParanoid" id="B5Y5J6"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="333"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACI65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="475" mass="52608" checksum="AAB6C552AD0E0A3F" modified="2008-11-25" version="1">MSDDWDLKICCMGAGYVGGPTMAVIAKQCPKIRVCVVDLSQKQIDAWNTDELPIYEPGLLEVVQVCRGKNLFFSTDIDAEIQKADVVFISVNTPTKTQGIGAGRAANIKNCELCARKIVEVSTTNKIVVEKSTVPVRTAQAITRVLKSNEKGLEFPVLSNPEFLAEGTAMADLMNPDRVLIGGQQNEAGLKAAQTLVSVYANWVPREQILTTNLWSSELSKLVANAFLAQRVSSINSISALCEATGADVLEISRAVGMDARIGNRFLQPSVGFGGSCFQKDILNLVYLCETYGLDECATYWNQVILMNDYQKKRFSEKIVAKMFNTVTGKKIALMGYAFKKDTGDVRETPSMFVLRDLIQEQAKIFVYDPQVSREDMWSEMDYTCGVNHQNTPGLDDAVVTATDPYQACDGAHAMAILTEWDEFKTLDFDRIYKSMAKPAFLFDGRNLLDHEKLRDMGFEVHAIGKPDPTAFTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNY5</accession>
    <name>B7FNY5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176616.1">
        <property type="nucleotide sequence ID" value="XM_002176580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNY5"/>
    <dbReference type="STRING" id="556484.B7FNY5"/>
    <dbReference type="PaxDb" id="2850-Phatr42619"/>
    <dbReference type="GeneID" id="7196296"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42619"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="InParanoid" id="B7FNY5"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="2">
        <location>
            <begin position="302"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54819" checksum="E81C25602AC83C3E" modified="2009-02-10" version="1">MTESNGNNSKRPSIENPLVDSTSVVAGLSPRASKKPRSSERKEEDGIPLPEVTQADLITLTSHPDAFGVDPIPISWGHPDPAVRGPVICTVRHSAQRNAIGAHQGSYCVYTGLAVAAGKLDPSYVPNLSLTSPVFQIGPYPSWSDPKKISALDPFGHLTTDAYGDWLEKGWDIRPTITWKDLLIVPHEMALNVFNFQAVTKAHIDLPECREAIATGRLVPDGKILLSSGQSIVAKAAIEPVWYLPELARRFQTTETNLRQSIFRMTNGMYPELITRPDIKIFLPPIGGLTIYIWGDPATIPDEDIELTCRVHDECNGSDVFGSDICTCRPYLTHAIEECIRTAQKGGCGIVIYYRKEGRSLGEVTKYLVYNTRKRQEGGDSAERYFSCTEQVAGVQDTRFQALMPDPLHFLGVTKIDNFISMSDMKYDAIVSTGIKIVNRVEIPPEMVPEDAKVEITAKVFHGYNAGEAYKNIDEEELKNTKGREYAYNEKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNZ2</accession>
    <name>B7FNZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_4761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177126.1">
        <property type="nucleotide sequence ID" value="XM_002177090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNZ2"/>
    <dbReference type="STRING" id="556484.B7FNZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr4761"/>
    <dbReference type="GeneID" id="7196298"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4761"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1047521_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNZ2"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="163" mass="18642" checksum="73C3FC9E34C64401" modified="2009-02-10" version="1" fragment="single">VAMDCEMVGVGPHRFSVLARVSIVNLRGDTIFDSYVRVDEKVTDYRTCVSGIRPENLKSEKAIAFGKCRAKVMQVLKGKILVGHALKNDLKILNLHHPWYNTRDTSMYGPFMKMSHKGIWKPRRLSELTRVVLDTSIQQKEHCSVEDARAAMSLYCSVRDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPA6</accession>
    <name>B7FPA6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_8940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177182.1">
        <property type="nucleotide sequence ID" value="XM_002177146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPA6"/>
    <dbReference type="STRING" id="556484.B7FPA6"/>
    <dbReference type="PaxDb" id="2850-Phatr8940"/>
    <dbReference type="GeneID" id="7196356"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8940"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1201859_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPA6"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF26">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP16-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="113" mass="12177" checksum="50B6EB6C8437C7B8" modified="2009-02-10" version="1" fragment="single">MDSDAPVPREAYRKLDSGVVYADIRQGSGAEVKQGSKVNLQWILRKSNGYFVDSSERNQSVPFIFTVGDGNAIAGVDEGLRGMKEGGVRRLLIPPSLAYVEGLEDGKPGPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPC5</accession>
    <name>B7FPC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_9255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176686.1">
        <property type="nucleotide sequence ID" value="XM_002176650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPC5"/>
    <dbReference type="STRING" id="556484.B7FPC5"/>
    <dbReference type="PaxDb" id="2850-Phatr9255"/>
    <dbReference type="GeneID" id="7196366"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9255"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_0_1_1"/>
    <dbReference type="InParanoid" id="B7FPC5"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="278" mass="32349" checksum="B82709D93BE3B35A" modified="2009-02-10" version="1" fragment="single">MDPPVPSLAARYTCASILVGVFAVWGKYTFVDEAKVPGGGRVELHNWKVPAALTTFYLVSLPLLRWFSNKFLLPNVDVKILLREAMILYNAGQVVLNAWMVYRFVDAVMFRGHPFVGGPVDLVDTGATFAIWVHYCDKYLEFLDTYFMVLRGKMDQVSFLHVYHHTSISWAWWFGLKLHPGGDGYFGALLNSWIHVMMYSYYTFSLLKVHCPWKRYLTQAQLLQFTTVLLYSFWSMNRMPPGSNWGHYAAHCIQDFEMISLFLLFLHFYRKAYSQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPD1</accession>
    <name>B7FPD1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176690.1">
        <property type="nucleotide sequence ID" value="XM_002176654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPD1"/>
    <dbReference type="PaxDb" id="2850-Phatr42739"/>
    <dbReference type="GeneID" id="7196370"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42739"/>
    <dbReference type="eggNOG" id="ENOG502S19T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1231941_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPD1"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="321" mass="36524" checksum="49A38627453E1B2B" modified="2009-02-10" version="1">MKRSANFMDWHPAFACQKRMMCTCLQFALLLIACSIPESYCFHQFSYRKILMPLFVHNSRRDFVLKSPPVAIGTLWLTNAPSPANAMINFPDLSKTMTAQGPVNRRVGGLASKIRNIGSVMDELQRDLMQERWDLVESYPAQLRSFVPVFTTYTDSAFPSDAPTDKGLRVALRYEVGRFFASVERFKQAASRQALDEAYLAYSEMALHFDRYLRVGGLYTYYDDSISTEPYFQGIADDALVYSDPKTDPPFVRDLVILVRGPEKGKTGIIIGMYSDGTNKSVIKLDRYKGMREIRVVANDWVAKRLGEQDPDDVFLIPRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPL7</accession>
    <name>B7FPL7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_8747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177233.1">
        <property type="nucleotide sequence ID" value="XM_002177197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPL7"/>
    <dbReference type="STRING" id="556484.B7FPL7"/>
    <dbReference type="PaxDb" id="2850-Phatr8747"/>
    <dbReference type="GeneID" id="7196416"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8747"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_1_1"/>
    <dbReference type="InParanoid" id="B7FPL7"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF20">
        <property type="entry name" value="IMPACT FAMILY MEMBER YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="190" mass="20146" checksum="436B95F8CF79F585" modified="2009-02-10" version="1" fragment="single">EMEVKKSRFIGYATHVDSWPDAQRVLQDIKNKHPKARHWCIGYQGGADPVNERSSDDGEPSGTAGAPIIAAIRAEALSDTLCVVVRYFGGIKLGTGGLIRAYGGAARLVLKDAPVIICLPRSSVTLTVDASYVGVIYDTIGKVGGAVIEEAYGADGSLTVTLTCETNQVDRFESGLKDATSGIVSFHCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPN5</accession>
    <name>B7FPN5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176745.1">
        <property type="nucleotide sequence ID" value="XM_002176709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPN5"/>
    <dbReference type="PaxDb" id="2850-Phatr42817"/>
    <dbReference type="GeneID" id="7196425"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42817"/>
    <dbReference type="eggNOG" id="ENOG502T0VR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1071409_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPN5"/>
    <dbReference type="OrthoDB" id="47337at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855156" description="SAP domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="262" mass="29130" checksum="7E0DDEF25339C998" modified="2009-02-10" version="1">MMPRKSLVSRIFSAWAFLLPDSSANGYSFHRKEQTLTYRNLIRTHPGVHCGHLYAHPGERSSTTNLEKKVLASAQAKLDYDRVVAAMDGGKIDTTTEMFPDRVPTSQWYVALAAAGAAAGVSFVLFQNIYISAFVVAAVLLAASQDPLDEDDNVYGALARLLGRATIQSVEASQPRVRALARAVLTGEEEIGELKRHIVELQEENHRLQIWIRRRVYVDENISAFSFDELKDQARCNGIKVGGTKKQLLMRLLEAEIVSVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPW7</accession>
    <name>B7FPW7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase of the ABC class C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176781.1">
        <property type="nucleotide sequence ID" value="XM_002176745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPW7"/>
    <dbReference type="PaxDb" id="2850-Phatr42881"/>
    <dbReference type="GeneID" id="7196525"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42881"/>
    <dbReference type="eggNOG" id="ENOG502QT9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394567_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPW7"/>
    <dbReference type="OrthoDB" id="189459at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="1">
        <location>
            <begin position="281"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="699" mass="77030" checksum="C553C0D79A66DA6E" modified="2009-02-10" version="1">MWKIRIVDDPLDVAGRNDATGVLLLQNKLAHATISLLDLFPDVPEVSGERIVQTALADFVSRQWTRDLHLVHTHHEQGCTFVVEALEKTTLHTRHRNRRNRSVSPHWTPYMLERTDIWCTPTGVLHVWVRVLAYNNDPTVVAGDHPSPVRRDCASDIFRHGQTCAVRTILASVVPADTATFVDAAQRHVATAMWQERLRVQLRAHNAVAFVADGSILPRKSGASHAPMASPPAIPFAAPVDSPLRRDVSVDLGPWKTYLSKPTLAATPGTWLVEETDTILTMTGLLIPRGVSLIVGGGYHGKSTILRCVAAGVYNKIPGDGREFCVTVDDAVTVRAEDGRYVNRCNVSAFIANLPVLPNSASDTVNITKSFSTGEASGSTSQAANVVEAMEMGASAFLVDEDVSAANFMARDGRMRALVMDESITPLLYRVNGLYQKHGISSVVVVGGVGDWLDVPDAVILMDKYVCHDATQKARSVSRQFSHGHVQYGGRGVVHRLNWESTGTPNPRRPTDAWSQKFDRQSTVISLLDGVQSLVLHHAEEDQAITNDEEEEEEAMIDLSRCEQLLGKKPQLYGCGLCVVWLLEASRQYPNLGLSDLLHKMDSAIDTEGLFNVVSAVGETNTSLQSESLPANVGLLIETLGCAFRPRRFEVGQALTRLRGIQLEELPVEEDLVEKAAREEEARKRQRLREIWEARRQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ53</accession>
    <name>B7FQ53_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177333.1">
        <property type="nucleotide sequence ID" value="XM_002177297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ53"/>
    <dbReference type="PaxDb" id="2850-Phatr42957"/>
    <dbReference type="GeneID" id="7196200"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42957"/>
    <dbReference type="eggNOG" id="ENOG502T24M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442455_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ53"/>
    <dbReference type="OMA" id="LMRSANH"/>
    <dbReference type="OrthoDB" id="49399at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="618" mass="67789" checksum="CE91B2768B23528E" modified="2009-02-10" version="1">MSNGEEADILRTMVQDRDQRILLIQRQTQEQVDKESRLEQELDGVNMETNRFKIAHQTEKTRLLHSFQSTSSRLESVQRDLQQQTVTLQNYATVVQKQNKPDAAQDSNYVMRMQAQLCKAMHSMGIVDHQFDLMQAEAEALVKFQKESIAQTAEEKTELELQLLNGLMNVDNAKREMEAKFQKELDLILKEISNINEQLEEDSDDEDKGDDEVENEEVDEEENNAKEELLKMLQSRKEQIEKLETATEEQAEVIEDLQGQLAEFGPIDPSLAPIVTPRPPPPETDPPPPDSQDEEEDYLAIVAARSRAAQAIVGSEDGSDVEDMDEIDLLKFAKSRLAGEDPTVKNAVEEESESESNTDFDESSAGEVDEEDEDIVETSSEMTPVLNALPGSLLGNDDGSIESVDGVKMAVGTNSVAGSIPTSPAPGREDGTTDNLLVTTEMQDDSTDRKSVDFTAESFATAAQQEQVSETPVNLLESSTESADEATPNVEAVDSSNAQSILSTDSSDQPDGNAVFNGTNTMDKLNNQNIEVEAPELGRDDDDAATKGGNTPPNPIEGTIADPTLEESFLAEPHVESENAVKDEMAVASEAEVNGVELEKKEAVELTETPPATAPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ60</accession>
    <name>B7FQ60_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_25</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177337.1">
        <property type="nucleotide sequence ID" value="XM_002177301.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQ60"/>
    <dbReference type="PaxDb" id="2850-Phatr25"/>
    <dbReference type="GeneID" id="7196786"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQ60"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="951"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1589" mass="178026" checksum="7AEFA33F89198471" modified="2009-02-10" version="1" fragment="single">LPHGTIYESTDRMEKVIIPPADRNEANLHPRLRIHEVLETDPAKAFEGTVSLNPMQSSVFEVAYLHRDNLLVCAPTGAGKTNVAMLSVVAHFRDVGLIASDRTTVLETGRKVIYIAPMKALAQEVVEKFSAKLKGLRLTVRELTGDMQLTRLQAEAAHVIVTTPEKWDVVTRKSGTDENALGNQCGLLIIDEVHLLADERGAVIESVVSRLHRLVESRQKQARIVGLSATLPNYQDVASFLKVPERGLFFFGPEHRPVPLQQQFIGVSAGTKDRFAKEKRMNEICFDVVLDSLQRGYQVMVFVHSRKGTGDTAKSLAEMASHEGVLERYFVTAGKEGSSGDAYSRHAEKVKKSRNREVGMHFANGMGIHHAGMLRGDRKLTEQVFSDGAIKVLVCTATLAWQVFRGFRLPAHTVVIKGTEVYNPEKGGVVDLSILDVQQIFGRAGRPQFDTSGEATMITSIDAFPRYMDKLVRAVPIESNFIKHLADHLNAEVVGGTVTNIQEAVTWLTYTYLYTRMRRNPIGYGIKEDEKNSDPMLKGRCNELVREAAKLLDLNRMIRYDQQSGNLSVADRGRVAAHFYIQSESIATFNEMLAMTDYYTDADLCRVICNATEFRNLKIRQEEMSELEELVKTACPLPLKGAGMDDRGRGLITDASDKAFVLLQAYISRAKIKSFTLITDMNYIASNASRVARAVFEICLKQNSAGPALKLLRIAKSADTRIWWFQTPMRIFEDEFSESVYSSIETKSGGKGYDSLYSALSLLDMQPKEVEIYCRWNKSNKGGRGGEKIQRFVRTLPNLHIECDVQPVTSSVMRFHILVTPNFEWNGRWHGGAQSFWLWVEDGENNRIYHDESILFAKRTFPDAITLDLSIPAFEPMPSQYFIRAISDSWVGSEMLLPVSLDHVQMVKDKTPITPVYDLSPVPVTSLAECKYEQLYRNFKCFNSIQSQLFHVLYHTDSPVLLGAPTGSGKTIVAELALLRMKRIFPKGICVYIAPLKSLARERLKEWKIRLGSAPLRWKILELSGDTHHDQGVVESADVLVCTPEKWDLISRGWRSYVKAEASENAGKAFVKRVKLLVLDEVHLLGEERGAVLEAIVSRTRFISQFVEEQNNAKTSKPKEDVTRIIGLSTALANPLDLADWIGIDTRNTGPTRMRGLYNFSSSVRPVPLTVHVQGYPGRHYCPRMATMNKPCFAAIKEYSPAKPVLIFVASRRQTRLTAFDIISYAAAEANPKRFLKCNEEVVDAIINTVSDEALRHTLAFGIGLHHAGISSHDRDVVETMYLSGKIQVLVATSTLAWGVNTPAHLVIVKGTEYFDGKSSRYVDYPLTDVLQMIGRAGRPGFDDRGSAVVMSTEDKKPFYKKFLYSPFPVESCLTGRIHENLNAEIASGTIGSVLEAVGYLTWTFYARRVRANPSFYGAQSSSEEDVEHLLVSIVKSTLRDLEDQGCVSIQSDELEAHVTTMPLGLATSNFYLLYRTPKQMQFVDEISLAWILYALASTHEFDELPVRHNEDILNEELSANVRWGPDVDHLLSGDQSNAYRNPEIFSDPHTKCFLLLQAHLEHAKLPISDYVNDTKSVVENIPRLLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQM3</accession>
    <name>B7FQM3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176894.1">
        <property type="nucleotide sequence ID" value="XM_002176858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQM3"/>
    <dbReference type="PaxDb" id="2850-Phatr32247"/>
    <dbReference type="GeneID" id="7196880"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32247"/>
    <dbReference type="HOGENOM" id="CLU_827593_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQM3"/>
    <dbReference type="OrthoDB" id="416042at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39313" checksum="417789E871E8D3CF" modified="2009-02-10" version="1">MAAPRREPRPFHLRRQSAYTIIACFVVFYIVSQTVVLIFFHLNSPKLNFGSDSWQRGFVSYGTNVHTQRFVSFPLYNATAEKAQALLYTKSFQSLERPLKFLHIPKTAGSAIENAAGENGINWGSCAFFHKPKRDICDYPGTEWPMRIGWWHLPTYVFPLAESDPYQHAEVFGVIRDPYERMVSEFYYICTLKVKDWRPDQCNRSRLHESAYMNQWLMRKMHDRETKTAAGYLLDNGHFTPQIEYIVGPHETRYVDYILRLDDTLNPQFAHLMQVFGLGHVELKKFQALGSAEDFKDRSDDTHLTTDALDKHTLDWIHNRYSQDFLDFGYMKRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQZ0</accession>
    <name>B7FQZ0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177491.1">
        <property type="nucleotide sequence ID" value="XM_002177455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQZ0"/>
    <dbReference type="PaxDb" id="2850-Phatr32365"/>
    <dbReference type="GeneID" id="7196938"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32365"/>
    <dbReference type="HOGENOM" id="CLU_1921190_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQZ0"/>
    <dbReference type="OrthoDB" id="49177at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="132" mass="14724" checksum="7BB610F540C2119F" modified="2009-02-10" version="1">MYRRQVGVLNLGSKSAPSEASLTVNDSLSTLTQWMFPRGERQTPQSSSASSTASSPSWSSRRHREIAAVETSEKESRNTNVKHLTRLSRYSESSVPAIVDHNDTWGQFVDTAEAEDELIRHSKVLSMRRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR14</accession>
    <name>B7FR14_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbamoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176966.1">
        <property type="nucleotide sequence ID" value="XM_002176930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR14"/>
    <dbReference type="STRING" id="556484.B7FR14"/>
    <dbReference type="PaxDb" id="2850-Phatr43222"/>
    <dbReference type="GeneID" id="7196947"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43222"/>
    <dbReference type="eggNOG" id="ENOG502RKTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014411_2_1_1"/>
    <dbReference type="InParanoid" id="B7FR14"/>
    <dbReference type="OrthoDB" id="414294at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24033">
        <property type="entry name" value="ASKHA_NBD_NodU_CmcH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="entry name" value="Carbamoyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051338">
        <property type="entry name" value="NodU/CmcH_Carbamoyltrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34847">
        <property type="entry name" value="NODULATION PROTEIN U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34847:SF1">
        <property type="entry name" value="NODULATION PROTEIN U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyltransferase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Carbamoyltransferase C-terminal" evidence="3">
        <location>
            <begin position="602"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="102367" checksum="954881784B80554D" modified="2009-02-10" version="1">MRRLCLFDATTKSTSEKLVFVLLVFQILSPGFAWIASDSRLPNSKLTWRDSHSTTPARTSHLASTPFEADLYDNPFNENTNKPSTAVPKDTKLVLGVNKYSHDTTICAADASSGQVLFAVAKERLSRKKHDAGNVATAVEACLEALDLDLDSIEHVVVNNHHHRVLPREVNVRHMEWECGLSINGGVEDGYDDPENLLPDARHHELSHHLAHAYSTAAQAPFDKGLCVVMDGMGEPLRTMLRAQETKDETYTSDFSFGFDTFQCVPSNVIEQSQLSYFDWREAESVYVFEKKERTIDLRPVWKRFTPEHSPPSLYNHGFENMDSVGALYSRASSHIFGDWNACGKVMGLAPWALHEWTDSRGAKLAPVVHNSPILQGKLYEDDGLHIDRNLLEGQPLISRNDPDIFNDDGTRRKRYDFDDNADKETLLDVDENDEYGENREETTKVEERIPIRVALDAIALASRMQIDLETVVMDFVAHMKAQTGETNLCLAGGVALNSVLNGRLARELGFAQTFISPYPGDDGIAVGCCAFGLFGNDRLDQIASTKARSGPARPAVWSQPLSPYLGPDASEAAIKAAIETAAPWLEVESIRNVDQRLQKMAEEVESGGVVAWYHSRSELGPRALGHRSILADPRKKGLVRFVNEKVKSRESFRPFAPSVLAEEASNWFDLGPSVLPDDQNVSPFMSMTAIVHESKRARIPAVTHVDGSSRLQTVTSTAEPLYHLFISKFFALTGIPMILNTSFNTLPSEPIVESPRDAIRSFLYSMGAIEMLVMGDYVIKRKPPNLRKLLGEVSKSGEMQVEPGCPIRAGPATFESSFALEAGVQAEEEIETVTRVRMPDRPTFSEKKAWFPLLDDLEGELLSVCDGTNTMNDIMVQYTPLPEGQDKIGKEDVEEAQTLLQNIVYRLVRLYEHTLISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR33</accession>
    <name>B7FR33_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177510.1">
        <property type="nucleotide sequence ID" value="XM_002177474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR33"/>
    <dbReference type="PaxDb" id="2850-Phatr43237"/>
    <dbReference type="GeneID" id="7196592"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43237"/>
    <dbReference type="HOGENOM" id="CLU_1328606_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR33"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="207" mass="23102" checksum="04357F926CF1006E" modified="2009-02-10" version="1">MIFDRMFDLEPSKEAGGVPRSVVRLPAAIETTPNDSRSQHSMPEARPHRSLRIPLPSSYVSRTQSELQLALEQEEAEHRDAAMFYRLVNGIKVRQSSQYPPSPNVEAPHNDSIASIIRTRMSDLAVIPAPTPPEQLPFHLHWQQCSRPNTLCWDSTAISPTVADPADEWSITGYEASTEPLEALQSSPAEMESLQLEEDEGVFSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR57</accession>
    <name>B7FR57_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_43259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176985.1">
        <property type="nucleotide sequence ID" value="XM_002176949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR57"/>
    <dbReference type="STRING" id="556484.B7FR57"/>
    <dbReference type="PaxDb" id="2850-Phatr43259"/>
    <dbReference type="GeneID" id="7196971"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43259"/>
    <dbReference type="HOGENOM" id="CLU_604787_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR57"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51104" checksum="734D51B71A692AAD" modified="2009-02-10" version="1">MASTAYLTPLWNTEMEYHAAYSRNAEWKHSCLLALGVVTAPWGEAIEDPPLREDPNAPLFLNLARSDLTEELEDDSTLSRTADPWMETALEIHKNMNRMEAWIDDVQADFVSVEMVNEEASLIQSTVTSYTATTANEVETLRSMIVLAKDGSVRGHWQHHQNGIVQILLDRLKHIAKFFGVLQQQRNRTAVWLWQDPLACKLVAAVATESSPQDNHLDEVLGLSSPSTHPGAVMSQRERRFLPTRPSHLLQRNLLDSYQQHEKRVRAATLQTQRPKSMFGAVKRARPVSTLDARQTSPSQQTTPTSTKRSKLGHLKELESMETEPWTKISAMVVSQDDPDLNQQYEQENQVALQQEAVLLKAKVENDLDAVQAMEQSMVDITALLSQFSELVASQQENVWNIHDATATTKENMEQGQEELVDATARTKASRHWTATGITAMGLILLIFHWIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR87</accession>
    <name>B7FR87_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dsCYC9</name>
        <name evidence="2" type="ORF">PHATRDRAFT_42423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176503.1">
        <property type="nucleotide sequence ID" value="XM_002176467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR87"/>
    <dbReference type="STRING" id="556484.B7FR87"/>
    <dbReference type="PaxDb" id="2850-Phatr42423"/>
    <dbReference type="GeneID" id="7196635"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42423"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067459_1_0_1"/>
    <dbReference type="InParanoid" id="B7FR87"/>
    <dbReference type="OMA" id="CKFRRET"/>
    <dbReference type="OrthoDB" id="44315at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="320" mass="36077" checksum="07432CA9E7E52FD0" modified="2009-02-10" version="1">MVALSIATTPLEDAMLHHIDVDEISDRVAIMRIQEDTTYRVKDYLAESTGIRKLASKPVDEDCRVKMCEWCYQVVDFCKFRRETVGIGMSYLDRYLCTPKGKEALCNRKEYQLAAMTALYIAIKIHEPLEMETSLLADLSRGCYTEMEFVHMEQTILQALKWRVNGPTLLGFVAHFVALLPESVHPAIAETIFDYARYQTEIAIAEHVLVSIKPSEVALAAVLNAIEGMDVALLPLKVQGKFVRNIERFSEIFIDDVEHIQSHLSLALASLLSGDVSEIIAAVTDIESEDEYVDDKSITAYNRRNSPVSVVQRNRQTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRG3</accession>
    <name>B7FRG3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rpe</name>
        <name evidence="15" type="ORF">PHATRDRAFT_53935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177037.1">
        <property type="nucleotide sequence ID" value="XM_002177001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRG3"/>
    <dbReference type="STRING" id="556484.B7FRG3"/>
    <dbReference type="PaxDb" id="2850-Phatr53935"/>
    <dbReference type="GeneID" id="7196672"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_53935"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_1_0_1"/>
    <dbReference type="InParanoid" id="B7FRG3"/>
    <dbReference type="OMA" id="CDLILIM"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000004">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005665811" description="Ribulose-phosphate 3-epimerase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="27812" checksum="F3E603CA9F38AD03" modified="2009-02-10" version="1">MKFTIVSLAAVVASASAFAPATKSVRSVSALNVWGDKDYLIAPSILSADFARLGEEVDNVLEAGADVVHFDVMDNHYVPNLTIGPMVCKALRDHGVTAPIDVHLMVSPVDAAIQDFIDAGASYITFHPEATNHVDRSLQLIKNGGCKAGLVFNPATSLDAAKFVMDKLDIILLMSVNPGFGGQAFIPAVLDKAREARQLIDDAGIDCRLEIDGGVKTENIKEIKDAGVDMFVAGSAILKEPRTLEAYKETIDTMRAELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS51</accession>
    <name>B7FS51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_43405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177604.1">
        <property type="nucleotide sequence ID" value="XM_002177568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS51"/>
    <dbReference type="PaxDb" id="2850-Phatr43405"/>
    <dbReference type="GeneID" id="7197138"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43405"/>
    <dbReference type="eggNOG" id="ENOG502S7K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494765_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS51"/>
    <dbReference type="OrthoDB" id="41192at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68747" checksum="4BADA008DBAC5D21" modified="2009-02-10" version="1">MITYNSGTFGFQLLFRLHGSAVFKSITPALISSIIYVIIYHTHDLENDDGELFDHPYPMGALISALTFLLAFRANFSYNRYWEAMTAVHQMHSKWLDAGMELAAFHLQSAAYDARKPPAFGSHPELKHLERERERLHAHTIEELESQLNSMENIQHSVRDRIKSVFNRSSRKANRTGSTRTKTEEQQTSPAPPLPSKGGQTMNLNNTSKSITAAGKISKYKKPRNPFKPWSHSKKPTSLPKNSKVSSSKDGTNAWEADSPPLFLQESAHLLSLLSAVAMSTLRNDLEQVGSPLDTFYPGVDWPHVDPDAMDADVRKDWALTTHRSYTVCKYLTGLSRTPKSRTLYNAARPFRVVGGVSDAEIDLLQAARGPLAKVALCTMWLQEFISREYLHGSTGHVAPPIISRLYQYTSDGMAGYNQARKVAYVPFPFPHAQITSLFVLVVVGLMPVLMLTYVTNEIFGIILNFLTVMCFAGLHEVARELENPFQNVPNDIPLNNFQAQFNESLMNMFTGYHPDAYWEVTQDVEPPTSSQLDALEEFRGKVQTAKEKVSQHGNGNKSTTARVSPKSSMRDDNNPEGDEFPIGVDNPVRANLEGNDSKERDQRPREIVQEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS55</accession>
    <name>B7FS55_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_9832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177922.1">
        <property type="nucleotide sequence ID" value="XM_002177886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS55"/>
    <dbReference type="STRING" id="556484.B7FS55"/>
    <dbReference type="PaxDb" id="2850-Phatr9832"/>
    <dbReference type="GeneID" id="7197427"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9832"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_0_2_1"/>
    <dbReference type="InParanoid" id="B7FS55"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854947" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="187" mass="21102" checksum="F46E830ED0AF01C8" modified="2009-02-10" version="1" fragment="single">MAWQWCTYGVCVCTFHLLEFGVTAISNPTVVSADSFLVNHSLTYTAAALTSWTEFGLRVALVPSWNYPSMSVCVALPLVLLSQMIRSLAMATAGESFNHLIQTTKKENHVLITHGIYKLLRHPSYVGFYYWSVGTQLLLGNFLHAAAFAVVSWVFFNRRIAYEEESLCLHFPHEYPAYVARSWMGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSH7</accession>
    <name>B7FSH7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_10005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177666.1">
        <property type="nucleotide sequence ID" value="XM_002177630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSH7"/>
    <dbReference type="FunCoup" id="B7FSH7">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSH7"/>
    <dbReference type="PaxDb" id="2850-Phatr10005"/>
    <dbReference type="GeneID" id="7197559"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10005"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FSH7"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="102"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="212" mass="23493" checksum="06D79C9515958866" modified="2009-02-10" version="1" fragment="single">RPVALVTSGGTAADLENQSVRCIDNFSTGLRGAIAVEQLLQRGYAVVHLSRKGSAEPFARALSQYLGLQQANHGLDVQTMVDGRLLSISFRTVEDYLGRLQLCAESLRDAQSLVMIFLAAAVSDFYVPAEGRVEHKIQSDGEDLVLTLKPVPKVIEELRQKWCPDAFVVTFKLETDTKILKEKAARAVERYGCHMVIGNLLKSRHNKVWILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSL6</accession>
    <name>B7FSL6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_25334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178003.1">
        <property type="nucleotide sequence ID" value="XM_002177967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSL6"/>
    <dbReference type="STRING" id="556484.B7FSL6"/>
    <dbReference type="PaxDb" id="2850-Phatr25334"/>
    <dbReference type="GeneID" id="7197580"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25334"/>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="B7FSL6"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="34704" checksum="FBAE0F418C094792" modified="2009-02-10" version="1" fragment="single">MEDSAPQGATDAQLGAAAPCESWPTSAQSYELIGKIGQGAFATVWRAHVSEKKACAVKVLNLDHVDTNLSEIRQEVQAMRLSAHPNVLTCHTAFVSNTQLWLVTPLMRKGSSLHCLQTARRVMRTQQQQQQQQEGEARVTPSMEDHILYILHETLLGLQYIHENGQIHRDIKAGNILLDGNGDVRIADFGVSGWLVQAGSQQEKAKTFVGTPAWMAPEVMEQVHGYDTKADLWSLGITALELAKGYAPYAKYPPMKVLILTIQEDPPSLDSYDEDEDDDDCVDEEFSTDFRSLVSLCLQRNPSKRPTCRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM7</accession>
    <name>B7FSM7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178008.1">
        <property type="nucleotide sequence ID" value="XM_002177972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSM7"/>
    <dbReference type="PaxDb" id="2850-Phatr43557"/>
    <dbReference type="GeneID" id="7197586"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43557"/>
    <dbReference type="eggNOG" id="KOG2131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596515_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSM7"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="196"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="418" mass="47383" checksum="600B68DF7978A20F" modified="2009-02-10" version="1" fragment="single">MVSAVPPSLTDVRRRQIVGRYIHELWTDGGSDLSGLAFPIFDGRLVALGRYVAFQDDDADHAITRKESSPSIDRVQCEDMTYDTFIQTYMYPNRPVVIGGLAENWQAGQEWVQDVGEARIPNIAFLRAQFGSERAPVYEQQTKGFGPTRPQASDSTIAEYCDWWTEQATLASETVAVEKESTLYLKDWKFLAAHPKYNLYEWPHYFRDDWLNQAMGNAYKFVYLGPKGTSTVLHADVLQSFSWSTNVCGKKRWFLIPPEYTYLLYDCFGKKLASHLHADVDDGMKTFFPGLQEARRHAVRVDQEAGETIFVPSKWYHTVENLEDTLSINHNWLNGANIGHSWDRLCIELAEVRPSRLDAGMGSEEIKSTEEICCGNSQIGDDLVLLWHVVTRKVLAVRNIIGASLSNQTISDIDAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSZ5</accession>
    <name>B7FSZ5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177749.1">
        <property type="nucleotide sequence ID" value="XM_002177713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSZ5"/>
    <dbReference type="STRING" id="556484.B7FSZ5"/>
    <dbReference type="PaxDb" id="2850-Phatr43645"/>
    <dbReference type="GeneID" id="7197358"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43645"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323784_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSZ5"/>
    <dbReference type="OrthoDB" id="46573at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="862" mass="97486" checksum="A4B0AD7B55DA569E" modified="2009-02-10" version="1">MHNHFLAEADKSNRKEASARLLSATKPFSRLQWREAIRTLEWWTNENGGSELSICIFAKLCEQESKGENELDETLAKKVAQSWARDFVAGVSTLSVAEFSRQLKICQEAIPSLRMDVSAIIHSANAKRQTQERSQGEKLAIPNISLLEEMESKIEKSQIQDDPSVCPDVRTINAAISASLSFDEPELAERVLTRMWNIYDCRQWQKIRPNHITYHNIMVSWVKTCRSTERAVRVERLLQQLKKRHSEHHYDKGLTPQRQHYILALSAYSRDGDLKRAQALFDYMLKSFTLTREISLKPTGKVCAVYLSALSRKPDVTAPVLAAAVVHNLFERFHDNMDPDWLPTPQMYTSYMKIWIDSGRPDGAQQAQKILDDMSTKPGNLSPNIMHYGAVISGWCKADEPDRAESIVRFLCEKTKVKPDIKCFLEVVKAWSSRNTSEANKRAEKLLVLMKEIEGTSGTERSTATLDIMRILSRSIKGGDAQRSEDIIHRMQSQYYLGHSSLKATTEHYNAALGAWSRSNEFESPDRAEALLLEMLERFDHGDNDLSPTEQSFTSVITCWGRSNREEAGLRAQAVFDGMQDRRDQQHLSSLCVTAASYSALIMAWARAGEPNRAEIVLQEMHNDYLNGNKAAEPNQIVFNATINAWGKSQRKGREKRVDQIIRLMQQLGDLTEVRPDIVTFSTAIASCMRSELSNAHELAESYLDEAKRLYAEGDSGCKPNSMCYGAVIQAIVRGGKSDAPLRAEKYLNEMISQSELDAKQVQMAFAATISSWAHASYQSENVLRAEALLDTMTAFGSKRGQQFLPGLRVYTEVLIAISKSEPRIRAKKATALSQSMQANSIFPDEICERIFNACFIRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTL8</accession>
    <name>B7FTL8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178437.1">
        <property type="nucleotide sequence ID" value="XM_002178401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTL8"/>
    <dbReference type="PaxDb" id="2850-Phatr44296"/>
    <dbReference type="GeneID" id="7197959"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44296"/>
    <dbReference type="eggNOG" id="ENOG502R0TK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_941614_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTL8"/>
    <dbReference type="OMA" id="FNCKSKP"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF1">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="31779" checksum="09FE79E94F572EFE" modified="2009-02-10" version="1">MTGNQRTELSSSPITRLNIINLIAYTLNVLITYGIGVAGLFDLPTNGDLSRKYQTLVTPVGWAFSIWGLIFTFQLVWVIFQTVSKRNRNSEWISAIGMGYFRICVAQAAWTLAFSNEAIWLSLGFMVLILVFLVEAVLSLIPKQASVGDYVLWKLPFTLHCGWILAATVVNLNVVLVAEGFSTNIQFLSAVGSLASLFLIGVFTAWRHIDYVIPIVVAWALLGVYVELGSAAASIVISFERSQIDQARYGAIIVSSALILATLVKGAFSLCQGRSDASTEESRYLRQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTR2</accession>
    <name>B7FTR2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178194.1">
        <property type="nucleotide sequence ID" value="XM_002178158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTR2"/>
    <dbReference type="PaxDb" id="2850-Phatr44332"/>
    <dbReference type="GeneID" id="7197984"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44332"/>
    <dbReference type="eggNOG" id="ENOG502SNSX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360003_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTR2"/>
    <dbReference type="OrthoDB" id="47180at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="778" mass="85691" checksum="507E666F3D29198E" modified="2009-02-10" version="1">MDFSYTTANAESVDDPSETVMATHEDDDEETEDGEIVESLEDVEIGDPKAQPRREETSTPDEHEESDEDSRSVPGDNHDGAVSGTRTEPHASTDGSPTPKSDEPKDAEDEGEELHEQAKMESAYSTRGRTADRDPDPLERLARDALGELAREKEPSASHSSFLSDSLTEEERRTRTRYLPEVEGLHALRKHEVKGDLSLARTLQPVPGKKSKRTEDAMDEDGGLSPMEDSTDANRRVVTIAGHALPIPSPAFVAPLTEATVPSARVVGSVTAFNPPQPPESVSAKYKHRMLRWENHPSEIQVDLTKYRKTVQKARSELHKAMAERERVETVQDHLRRHFFQHIDCLNAEWRQLQGEFHEIQQECVDAADLLTSRTRSRGAGKSSHVMRDVLQVLRSRGAELQTKSLNLHSIPTSSEPALRGMGGVGLRSFLTWDRSTVIAPAPAAAAWLLAGDAVETPCGPGTVQAVYPPGDALEKGGDADKNPDSQPSEGLTGPRVAVQLPFGIGYFPLDAVMTKENPAAYDDARLAQRWKGLMETATAVGSVLDLESMATTTNDGTKKEESVDGMDESGSNVESKDDMEESTVARRIPFGAGMLPIGTARGHDLYKRKLADLENDLDKPLYEGEGVLGFKGNKNVPTATREAEDLRQERIDLEAKLHHLKNKVYRQRNIRILNERTYAGAQERSTRVKSLITEMRMDLMSLRSRLDDEVRELGITGDQAEAILTSFYRSLDSQHSGEASPPKRQRRAQDDLDDDEEMASAQAGSTDVASDSGLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU40</accession>
    <name>B7FU40_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_33874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178533.1">
        <property type="nucleotide sequence ID" value="XM_002178497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU40"/>
    <dbReference type="PaxDb" id="2850-Phatr33874"/>
    <dbReference type="GeneID" id="7197887"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33874"/>
    <dbReference type="HOGENOM" id="CLU_077033_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU40"/>
    <dbReference type="OMA" id="NDDHEAM"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="31206" checksum="DB026A2F4753E56F" modified="2009-02-10" version="1">MAPQEANAIDDREQTHPDETEAFLAARLVEFDKEVALLTEQETKFLRQAQANCSELLDQNFKLMFLRTDVFNVQLAAKRYASYWEHRVGLFGPEKAFLPMTLDGAMKDDLETLALGYTRTVQDHGRILFMDPSRTLVDRDIDSIVRCQWYVSTKALMSEPEMQKKGAIFVLDLDTIRHVDRPLIKRMAETTNDSFPLRVSLCCMINPPPLTDFFVKIVKLFMKPKVRQRLYVIKGDQKLVKHVEGLDMKTLYTALDHDKWIETMREKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUG0</accession>
    <name>B7FUG0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_26190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178316.1">
        <property type="nucleotide sequence ID" value="XM_002178280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUG0"/>
    <dbReference type="FunCoup" id="B7FUG0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr26190"/>
    <dbReference type="GeneID" id="7197790"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26190"/>
    <dbReference type="eggNOG" id="ENOG502QPJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_1"/>
    <dbReference type="InParanoid" id="B7FUG0"/>
    <dbReference type="OrthoDB" id="5210at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001953">
        <property type="entry name" value="PRK00733.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001960">
        <property type="entry name" value="PRK00733.3-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="742" mass="78144" checksum="C25AE87F8E500CC7" modified="2009-02-10" version="1" fragment="single">MYALILLAVTMLFFFALPIEWAILSLVFGSCGFGAIASLWLSRAVLQCDDGTPEMRAVSDPIREGAEGFLRVQYTSIAKFAVPLAALIVFSYQFRPLHPHDAKGVGLLGNTLLGVVAAVGFVFGALCSALSGYVSMWVAAQSNIRVASAARRTYGEALVVCFRGGAFSAVLNLTLCIVGVTTLYTMLSTVFVNAAGLESTDIPMLLVGYGFGASFVALFMQLGGGIYTKAADVGADLVGKIEQSIPEDDPRNPAVIADLVGDMVGDCVGSSADVFESVAAEIIGAMILGSTLADEAGMSHNHATKFMFFPLVVHAMDIVVSSVGIAFVGVTRDSADSDPMKALQRGYRVALLLSVVGFYIITHWLLALPENPEAAFRFFLCGIVGMICAYIVVLSTQYNTDYAHRPVQSIAEASTTGHGTNIIVGVSVGMKATLVPTLTVAVAVLLAYHVGASTGIGNGRNAGLFGTAVATMGMLSNAVYILSMNCFGPIADNAGGIAEMSMQPEQVRDVTDRLDAAGNVTKAITKGYSIGSASMACFLLFGAFMDEFSEYSGLPFTTVDIATPEVLVGGLIGSMIIFYFTGLAIAAVGRTAHEVVIEVRRQFKENPDIMDYKAKPDYDRCVGLVTKAALKEMQFPGLVCVATPILVGLIFRFVGEATSRPLLGAEVLAAYLMFGTVTGILMALFLDTAGGAWDNAKKYIELGNFGGKNSEAHKASVTGDTVGDPFKDTAGPSLHVVIKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUM9</accession>
    <name>B7FUM9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">chk2</name>
        <name evidence="18" type="ORF">PHATRDRAFT_34071</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178626.1">
        <property type="nucleotide sequence ID" value="XM_002178590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUM9"/>
    <dbReference type="STRING" id="556484.B7FUM9"/>
    <dbReference type="PaxDb" id="2850-Phatr34071"/>
    <dbReference type="GeneID" id="7197616"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34071"/>
    <dbReference type="eggNOG" id="KOG0033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="B7FUM9"/>
    <dbReference type="OMA" id="EMQHPHI"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="41"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="355" mass="39770" checksum="114DE65EF82E63E7" modified="2009-02-10" version="1">MGICGSSEAAAQNVSNADQKPPAQHGKAEDPRSGKRFGDVYKMGKELGSGAFSIVKSGQHKQTGESFAIKIVTKSKLTQEDETALKDEIAVLKELKHPNIIQLYDVYEERDFYYLVTEQMAGGELFDRIVQKSYYNEKEARDVCKILFEAMTYCHSHKVAHRDLKPENLLLLSSDNDSNIKIADFGFAKKCPKPQCLKTQCGTPGYVAPEILEGTPYDTQADMWSLGVIVYILLGGYPPFIEQNQRELFRKIRKGQFEFHDEYWGQVSKEAKHLISSLLTVHPTKRMDGPDSLTDKWITAGDDVLASNDLGTNLDKLRSFNGKRKLRAAVQTIMAAHKLTSLGVDLKKNLDETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV67</accession>
    <name>B7FV67_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_19518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178872.1">
        <property type="nucleotide sequence ID" value="XM_002178836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV67"/>
    <dbReference type="STRING" id="556484.B7FV67"/>
    <dbReference type="PaxDb" id="2850-Phatr19518"/>
    <dbReference type="GeneID" id="7199509"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19518"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_1"/>
    <dbReference type="InParanoid" id="B7FV67"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="84"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="479" mass="50569" checksum="003FF143A2B4542A" modified="2009-02-10" version="1">MIATPRLWCPVAFRVRVRATRWGIASPAGSISGRGWASSSSEPVVESAKDAPDPTGTKTPVSQRELDALPISFADISRAEVAIRGGVVRTTCERSPFISELIGANVYFKNEFRQFTGSFKERGARNAILTLKKKLGGALKGVIAASAGNHAQALAYHGRSLGVPATVVMPTVAPLAKVDKCRKFGARVIIKGSHIGEAKEFAETLVASEGLEYVNGYDDPPILAGAGTIGMEMIDDVPDVDVVVVPIGGAGLIAGISCAIKTLKPDTKVIGVEPKFCASYTAALRAGKPVPAPFTPTLADGLAVPIVGAHAFEVARHYVDECVLASEKCISLAVLRLLENEKVVVEGGGAAGLAALLPGGPLDRADMKGKTIIVPLCGGNIDTTVLGRVLDRGLAADMRLVNFYATVSDRPGGIAKLAQLLSDEGASIKDIYHERAWLHTSVDQVQVKCVVELQGEEHGQRVHRALLNHGYPVNWNVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW18</accession>
    <name>B7FW18_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178807.1">
        <property type="nucleotide sequence ID" value="XM_002178771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW18"/>
    <dbReference type="PaxDb" id="2850-Phatr34440"/>
    <dbReference type="GeneID" id="7199814"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34440"/>
    <dbReference type="HOGENOM" id="CLU_706905_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW18"/>
    <dbReference type="OrthoDB" id="47942at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="391" mass="44097" checksum="09868087762C5C4E" modified="2009-02-10" version="1">MPLPMVLRNCNTLQKPKVFFHQIPHTFKFASMQPTKQSGKVDALNLNGSEPGMIESIARREVPQASIHANRRFRFKSFFPVAVSTIGLVVLLGSMKNTRTLSEVLLANRDIDKTIAKSYTENDVIYSVEQGSIENNLTQTGALFTPNGRRKERTRSGPNNKPPQKYRRDRQGQRMKISGPVLIMSLPKSGTTSLQKYFQCGLATRGASAHYWSYDFQDQIGKCMESNLKENIPVLTGCGIKNATTAFSDFGLVRQKNEGQGCFYPGFSDEFWNNLAAYYPNATIVLGTRGAESWHKSAEKWASGSLIYRWRRHCDNFPGMNGTAADFAAFYRRYSDMVKTRAAKHNLRYVHVALEDPETPLRLHGQIGFRVDCFKVCRPKTGCTGFNPLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWF3</accession>
    <name>B7FWF3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nad-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_55575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179147.1">
        <property type="nucleotide sequence ID" value="XM_002179111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWF3"/>
    <dbReference type="STRING" id="556484.B7FWF3"/>
    <dbReference type="PaxDb" id="2850-Phatr11559"/>
    <dbReference type="GeneID" id="7200293"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55575"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308483_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWF3"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="112"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="593" mass="65798" checksum="2DBF659530601694" modified="2009-02-10" version="1">MESVFDDEPDVINDHGSSPGPCCASISKAQHLLGYQPHTSWKEGLAKTREWYQTRSVKHRRISTKDADKTLVAAQIRPTPTRATTRTNLVAAPSDWERIPKVAPHNGTKTVLLTGAAGFIGSHVAEGLLARGDTVILVDEVNDYYDVRIKESNLQLLQETFGSARLRIYRGDLANASFISRVFAREKPEWVCHLAARAGVRPSIQNPYVYLNSNIVGTMRLLELSRIYNIQNFVFASSSSVYGGSQSTLFSEDERVDRPISPYAATKKSCELMAYTYHHLYGLPVTALRFFTVYGPRGRPDMAPFKFVDRVSRGLPLQQFGDGSSSRDYTYISDIVDGVVRAIDRPYDYQILNLGKGSGTKLIEFIKLVQKYTGKNATIQYLPDQAGDVPYTCADVRKAEHFLGYKPKVSFEEGIRLTVEWFSKTYVPQQSVKKETKRSSPKTASKPSKGKAKGKAPANKAPIRNYPANFSGYMMPPGGVMPPEKKKYPLAGGYVVPPGAIDPDTNIGYAFGGSIDGATYKPTEVDSTSIFDFSVVNQQLKTVIQSNAEKIGIVALDMAYVQWLIIGFLVTCRIFLGHRVRICRNTGQSLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXG1</accession>
    <name>B7FXG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_35058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179330.1">
        <property type="nucleotide sequence ID" value="XM_002179294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXG1"/>
    <dbReference type="PaxDb" id="2850-Phatr35058"/>
    <dbReference type="GeneID" id="7199996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35058"/>
    <dbReference type="eggNOG" id="ENOG502S4BH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025303_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXG1"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051030">
        <property type="entry name" value="Vitamin_B12-ABC_binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860:SF1">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="6">
        <location>
            <begin position="166"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="469"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="672" mass="73602" checksum="7C41B35901227F4F" modified="2009-02-10" version="1">MSIESLAEESSSVSVTDLRIVCLIPSATDICVALGLQAAIVAVTHECDTNLWSRASSRTAVKIITRDGVNGNETSQGAIHDQVVASCRAKDEAVGDGDIPALADVPSLYPIWEDEFREALQLNDVHDSSKRLVITQDLCEVCAPSSETVRRLVGKDASQPPPPHEVHVVSLTPQSLWDVAANILTVGHACGVPRRAKIVHDAFLSNLQTLETTVTEVRSHDGAPKLFLLEWLDPPFDGGHWILDMMQFAGVQPAQHKHTQKSTSTTWAQVRQADADVILVACCGFGLERNVRDTFGARNQLQQLRAARNRRIYATNGDHYFARPGPKLLHGAIIMALTAYADQPEVVQAIQALDFVDAELGGYQMVDVLDPTIVQANNDVPDMEDFDRLHREACSAGSLSYPDPVTGYKVFTELAHRQRGKCCGSGCRHCPYNHENVKNKAGKIQQPAMLTAGDQTGPLALSNGNLHVLFFSGGKDSFLAIRALTRQAKQTAPFGLALLTTFDATSRIIAHQDMPIDTVVEQATHLGLALIGVPIHRGSAEGYVTRVRKGLEVLQSSVKPPSKVTTLAFGDLHLENLVEWRNSQIGSLGYKLQYPVFQTEYEILWQDLEASKVPCVVSSSTVDHIRVGDVYSREFAQRLPECVDRFGENGEFHTIAQVWEVDRITALGFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXL6</accession>
    <name>B7FXL6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179577.1">
        <property type="nucleotide sequence ID" value="XM_002179541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXL6"/>
    <dbReference type="PaxDb" id="2850-Phatr45414"/>
    <dbReference type="GeneID" id="7200533"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45414"/>
    <dbReference type="HOGENOM" id="CLU_718599_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXL6"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="7">
        <location>
            <begin position="108"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="375" mass="43530" checksum="6B2FD61F97CD34FE" modified="2009-02-10" version="1">MHQRHRHADHDVRTDVEVGTRPLAKGEDPSCGPRTAVRRVVVRRKRKTRHQWRSRDFRRPFAASLVLLLVCLILWTIGWRRRRTVVFERSLVPTDPIHISPDIKVSVVIMNHSRPRMVRESNLVQTLAAHDSIDEILLCHSNPVTAFEYPHDKVRNLNATEANERMGLSLRFHYCSTARNDWVIHVDDDQELSSDAINQLISTFARNPHRVVGKFGRAYHYWKAPQRHGYDTKNVLGPSEVILTKFMIVERKVCESFFQYQHVVQDMVSESRPLWNGEDIFLSLTANHVYNVPLQGPYGNLALPLDVWEASDSFKDDDTGAHDVSGNMDRHRIWNVGLVNWWNAFYRAQCHAAYRGRLWYTAKQRLAAIEDTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXU2</accession>
    <name>B7FXU2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179617.1">
        <property type="nucleotide sequence ID" value="XM_002179581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXU2"/>
    <dbReference type="PaxDb" id="2850-Phatr45477"/>
    <dbReference type="GeneID" id="7200702"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45477"/>
    <dbReference type="eggNOG" id="ENOG502T0QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_895641_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXU2"/>
    <dbReference type="OMA" id="PIIARNN"/>
    <dbReference type="OrthoDB" id="48864at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35473" checksum="F10EB082785304CA" modified="2009-02-10" version="1">MGRVARYKKVKACDPYSKENGGRIQLDEVGIWGIGKDSRKPKKRSKTSERLRVKRKKTTEIDDGFDAPPEKGDDFDMADLYGTLKQEKVQNEQFDLGSSVKAHTTIITKTPSKPNPPIDEDDKKTNMILKLDEQVDKKKAAVQSLGRMEGETKNAFRKRVKAETRQIIKRESMDLHNPEKRQKKKEFLNKKKSKKRKASSLSFGDDDDESNYQSDTTVEKNGGLITGERAVAARAVATQAHFGEQAERPPVFRQLPRGAIKKADKKSSVSKLFRDEDILAEHQAMESIRRKVQAQYSLIKRQRKSNNDFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYK2</accession>
    <name>B7FYK2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179947.1">
        <property type="nucleotide sequence ID" value="XM_002179911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYK2"/>
    <dbReference type="STRING" id="556484.B7FYK2"/>
    <dbReference type="PaxDb" id="2850-Phatr45698"/>
    <dbReference type="GeneID" id="7200472"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45698"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302579_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYK2"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="908" mass="99904" checksum="538A08D5505AF83B" modified="2009-02-10" version="1">METYSSSADDSSDEEFLALGENREGKVDREALVRKKLLESFYGKSAVVAADYEPNPISLDDGDSEDEDSVEFKRSSRKLASSQDLDSPYFDAQAHTTKHIHASSVHELLETEERLALQVRTLDSTMQTLVYENYSRFIDATDAIKSIGVNVKANEDGLDRLASGMKRIHDTSKDVEDALGSLRDQVAEKIRVKRLLTRLDTLLKLPKTLQSQIGAGKYRSATRNYLSASSILGQHSKGFESLRNIEVECHEILVEMKEDLKRKLLQWSGHFQDVDQEDPNAEMGSIDGRTIDLPKNMTDIFECVGTLFILFNSHAEDYLEADFSGDDLQSMAMSAAARTIERMLDAHVLEVQESRFEGAKDLTVSINLTNSFSHVESSQNQSEGSILVPSDVLDTILEVATLFGLTFGAAAESSYMIDFISKSFGYFLSHVRSVILEVGFEAASSEETTTRDDGNYTGDDVSTALATLMKAVRQLASGLALPDIGIGVDYASKLVDQAMALSESMVRRRVDRKFQELRLSVVTDCMLPFAERMQIERGNEFRRDAQQAILNSALSDCIQLIDDTIRSVLAEGREHSDSISAPDLPVLKDAVYSSVRRFASWLAGVFECLAGGDSCDATELLEVNLLTTEKDGDNEDHEGIDTMAGCFSDAVSQNQSQTGIVQLVDSIVRKLQSISATTGRSMGDIGCTLAIAQLCLLAEESVSDEIEESIQSYVGGGKKKSRGMFPTDASLSAEMKVSRADDIIARQFQLSSSRIIAQYAVYQGHQAADALTAGLLATNVSGKDFRNRPSDAAVKALEIARVTALDCYDVFGGRQRAGPVSYLADDSIPEFTKSVVGRKTGLQLDVERMFMDNVVSVLPHPGEIVDPSRNAVLYIFFKSAFRGFAEQTRAFLSREAMLARLCRTYYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYP1</accession>
    <name>B7FYP1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_45790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180007.1">
        <property type="nucleotide sequence ID" value="XM_002179971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYP1"/>
    <dbReference type="PaxDb" id="2850-Phatr45790"/>
    <dbReference type="GeneID" id="7200924"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45790"/>
    <dbReference type="eggNOG" id="ENOG502S61Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484399_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYP1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="8">
        <location>
            <begin position="98"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="9">
        <location>
            <begin position="385"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="557" mass="61354" checksum="15D3BF1821AA3F0E" modified="2009-02-10" version="1">MATSVGARLVWGHAKLTVLATAAAMSPKLRVASCDAGQSPTPPTRSINNAVLRKKMTSIGHFSMISETAFNPSIVTFFIKLSGPPMTLPDFAKLWQTREMDQRHERFHQAVSETHPGHFEAIPLEPEQDPVSRHLSDTIFPSSRQDLQARIQTTQTSRWNLSNELWHIYIASSLEKRESLLLFRGHHALADGASMGAALMDLSDEAAILQSQIRTLLDARKIKARARTWWQKVFRSLGQLWWLFSGSIRAVCYQGELLLWAWWNPSPWKQIEAASNSSNVATQDEADVPLRNISMTTAAPVDQVKWVAQMLSQDSGRKITVNDVFCSCVTAALAKQFQYHRQRMLILAEVAGDKSTQPLPPIERFHVTIPVHLRGGIVLPGESVGNRLGAFTARLPGEIDHAITLTATERLRTVHDELAFIKSTPAALVSHLLAKVLSTASRVLPSTWTSAAFAASSANSSCVVTNTRGPPQPVHMAGRKVEAIQGFIPLPPGIPIGVVVSSYASDLGLTVTAEAWAVPNADLFLQWVLEEYLELVRAAKAKSEILERQQPYAVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYY4</accession>
    <name>B7FYY4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180060.1">
        <property type="nucleotide sequence ID" value="XM_002180024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYY4"/>
    <dbReference type="PaxDb" id="2850-Phatr45862"/>
    <dbReference type="GeneID" id="7201102"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45862"/>
    <dbReference type="eggNOG" id="ENOG502RWMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575526_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYY4"/>
    <dbReference type="OrthoDB" id="10676949at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="531" mass="58223" checksum="3FB033301E65146D" modified="2009-02-10" version="1">MVATVPVTQLAQYVPYPCLSSMGPFLVFRSPTPGLGSARVPDSSQGIVSSAAAAGFVCSPTLSLHQSSSHPTRSLEWSSTETSLKSTPADENEDIQGISDLKSSLSGMFRVNSRTPTPVYGGDPSMGLSPSDLEAYFAQRQIEIDATATSISNSSHSPHISKNSTSSDDIEGVYLEPDVYVQSQKWMQPDGALRGVVDDRTWQSVDRRYKQVARTLVQQAPYSPDTTWNSGNADGNDNISLDDLWAAVQNQNTVDASSTLSEDIHRKVFEAEQGFLDQSETFRQALVDSSKASEAAALRHGAKFQERQKEAIDRLNVQIADFEAELKVTTPAHPSSLDFTAQPRCRKCFCRLGEEEVRSATTSNGFCQVCHADDIVERSRQETAQASADQKRLATQKRREEKGRKMPSSHRGYDKQTSDLREDGVSRPFPQTTLGRSAPNSHAQPTRTKWPRRDSLPGYNAHERRGLPPGTRSLSSATPIPKSPSPVASTLAEKKPKKIESERSESMVETQAQSSIHSWAEVADEDTDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ51</accession>
    <name>B7FZ51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_45914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180288.1">
        <property type="nucleotide sequence ID" value="XM_002180252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ51"/>
    <dbReference type="STRING" id="556484.B7FZ51"/>
    <dbReference type="PaxDb" id="2850-Phatr45914"/>
    <dbReference type="GeneID" id="7201003"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45914"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372794_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ51"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC48479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="746" mass="83599" checksum="0E6023E85679D728" modified="2009-02-10" version="1">MDNDSDDDNLWGDEPDWFGDNDDDKNSNKQHGEASTVLPDVPVAQHLLILLDCGPDMLRASLPDPEFPDDLIAPLDVVLHACEALVRAQVRASVFAATGQRDALGLYCYNTRPRLPVPTTTATTKTTTTSFPREDYNDDEEEHEDDNDDDYDRFVHGPLPSTAHEIVPLAPPGKAAVQTLQAVQDHPVRGRRIDLPQLYGHRHVTSPTTTPTTPTTTAPHPLQTALFHALQVFGRAKCVRKTTPTRPADWQHVWIFTNNAHPVSSDGDDPDGCSQRQLLQTALHDAAEAGIDVTVWPLPNGPDQDNVDSSVYEQLEMDVAPSTAWTLLVDILPETHRQWKQARRAVGVPLLLPDWKERPPNDPNIQLNLYRLVQESRPPKQYHVHQETGRALEKLTQTVTVRGSELLEQSWGTGHAKNSWGGGADRIQTYVEFGGEKIPMSYADRDAIRRSCNANPDFASLILLGFHDDQSIPLAHTMERSYFCVPDEESVEGSTAAFAHLHASMLRKKVVAVGELLTKVTAAARLVALVPLPEERVDSHFDDELPEILRPAGMLVVSLPFEDEVRELDDDEATNVWEATGTDVASPDLVKAATKLIQRQIIDSIRIGENFENAALLKMWNYIEHVALEEPMPEQPASETILDKDLVLERARHEIDVFLANLPDDSIVEKMPRKRKVEPDDSRLDWFTIWSRDQYFECTNSDLKKKLRSCGEKVSGKKQDLIDRLVPILENEFGKRVIKSEPLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZD4</accession>
    <name>B7FZD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180130.1">
        <property type="nucleotide sequence ID" value="XM_002180094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZD4"/>
    <dbReference type="PaxDb" id="2850-Phatr35830"/>
    <dbReference type="GeneID" id="7201044"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35830"/>
    <dbReference type="InParanoid" id="B7FZD4"/>
    <dbReference type="OrthoDB" id="1933874at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16255" checksum="A50DF248BA2F3FF4" modified="2009-02-10" version="1">MEFQVRVRSARLAAAPAKEAPVAVKKTVIKKAAPKKDTKKSDHPKVVDEKDHPAESPAAPATPAAEDTGDEKKTGTDDQKKTTRANTIVKAVGDKAKISINAEKPGKGNFVVRVSGQDAPLVELLGLKRPFPPLKALDMEEVCEKVLQAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZK8</accession>
    <name>B7FZK8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179964.1">
        <property type="nucleotide sequence ID" value="XM_002179928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZK8"/>
    <dbReference type="PaxDb" id="2850-Phatr45729"/>
    <dbReference type="GeneID" id="7200881"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45729"/>
    <dbReference type="HOGENOM" id="CLU_090175_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZK8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30365" checksum="A4B6A1C41C8896BD" modified="2009-02-10" version="1">MPVWSTKSIVPVGSRSYLLRDTLTVSLSPPDFNLPTDCSDSAPIGTRMFTQSVATASTTFATMAKARPKQRHLDVDGSKSYDNVQYEDCHEEDLDEEDSNFCYVPFQTDEPEDSENRNEHCCESVAYWYVLPVLLLVQFGLAFANDPNLQSTHGGVVQWRIANYSIALFTVTHYLYRNTLQECHVYDTILGIVPDVTVNVTLAMVLWGRVDVALGVLLGVLLFMSLLVAGVSMYHLLVDVPKFSNDTRCRNDGDSKDLRERLEYHPIVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G008</accession>
    <name>B7G008_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_46087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180393.1">
        <property type="nucleotide sequence ID" value="XM_002180357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G008"/>
    <dbReference type="PaxDb" id="2850-Phatr46087"/>
    <dbReference type="GeneID" id="7201330"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46087"/>
    <dbReference type="HOGENOM" id="CLU_320169_0_0_1"/>
    <dbReference type="InParanoid" id="B7G008"/>
    <dbReference type="OrthoDB" id="47926at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05562">
        <property type="entry name" value="Peptidases_S53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034075">
        <property type="entry name" value="Glr3161-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855662" description="subtilisin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="554"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="907" mass="95406" checksum="799C451F5D76824C" modified="2009-02-10" version="1">MNPSFNTFLALVFGVLVILVAWTTFYATPQGTSSAQNGPYDHDQRHRLTQAASSDFVLTRVKKNDLDKIGTMLGNMVEALEKPNSMVEPATALSSQSSADQSRNTVLVDVTGTDGEILKIILDSYGCKRTGCYGNSCSAYAPVDRLVAIAGSDVVLELHPALPKTNSGSIVTEGDRAMDADDARTQFGVSGEGILVGILSDSYNCLGGAAGDISSKDLPGGQNDIVILQDLEGDECASAKDEGRAMMQIIHDVAPGARLAYRTAFRGTSDFASGIRELAQAGCDIIVDDIGYLTEPFFQDGDIAQAADEVVAQGIPFFSSSGNYNEWTWDDPNGFRSSGQTFTDGESSGDRHLFDGAVASQSIFIENANSVYSFTLQWDEPFRSVPGSQIGSASNLDVFFLVNGNVIARSTDNNIDRNAVEFLQVNPSTIAGVSGDTVELEMIITLVEGPAPSFVKVISFNEAEFEFSASTGTSFGHPNAGRAAGVGSAVFANTPEFGRDPPLINANSSPGGIPIFFENSGSRLGAAVVRSQPRFVGPDGGRTTFFGNAPEFRFFGTSAAAPHAAAVAALMLEINDSLTPDEIYTILQETAIDMEDPNTSEFEVGFDFRTGHGLVNALEAVRRAEPITPGEPTIQPTAQPSSIPTVTSMDAPTTGDDEPTSQPTFEQAAISDVPSNSLSLAPTGSTLLPTNQATTVAPTSSTSFPTGSPMTFLPTAIPPTLQPTVTSTSIQLNLNNFLLTLLGTNINEEALRQSLIEYLLQELSKDFPDLLSISLDLVSFTELGPNQLALVEYSGLATFPENSVVSLKELLKAQTEALKHFSDVEAAIVAGGNDVRVVSIEVDHGSSSKGKSSNSTTMKSSKSGRGKGKAKGSSSRDSTSSKTGGNGSTNGGKGSINGGKGSNGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G016</accession>
    <name>B7G016_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_35977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180601.1">
        <property type="nucleotide sequence ID" value="XM_002180565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G016"/>
    <dbReference type="PaxDb" id="2850-Phatr35977"/>
    <dbReference type="GeneID" id="7201435"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35977"/>
    <dbReference type="eggNOG" id="ENOG502RMTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028773_0_0_1"/>
    <dbReference type="InParanoid" id="B7G016"/>
    <dbReference type="OrthoDB" id="410754at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35791">
        <property type="entry name" value="UPF0754 MEMBRANE PROTEIN YHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35791:SF1">
        <property type="entry name" value="UPF0754 MEMBRANE PROTEIN YHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="551" mass="61949" checksum="4DFB652D44A1643A" modified="2009-02-10" version="1">MPSHRQVQSIGTRNGVKLGRFGIVSALCLIITPSAAFTTTSSFPVIWRVEPNLLQGRNPISRFHFRTPDYATRPRRRGPLTTTSADENDKKSGPLDKAVAKFKARPGTYLLIPCVAAIVGWFTNWLAVQMIFYPVRFRGIPIYRRPEIPLGFLGWQGIVPCKTRPMSEAMVEMVTSQLLTVEEVFARLDPKKVASLLAPEVPKLTNSILQDLFPKWVTAMPSAVFQGLDSVSQGVMMHFNRKFLEGLTKNMQSNIDSIFSLRNCVVDQMLRDRSKLGELFKICGQKELDFLTNSGLWFGFLLGLIQMAVALFWDNPWSLSIGGGIVGLATNWLALKWIFEPVDPTRIGPFVLQGQFLRRQPEVAKEFSAFFANQILTAEQLWYSVLNDPATKPAFATMFASHFTNFVHKITHGFRVTLEPETMKLAAAKALEKLPNHVPVLFPYMDKALQLESTLRVKMEQMTSRQFERAGAVLGFAAGLVQQGLETGAIRMPNVWQVVRDFSKAPKAQSKLVFERSRSALARSTRRIRQALVGPFRKRRDKLPGDESEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G067</accession>
    <name>B7G067_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylglycohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180424.1">
        <property type="nucleotide sequence ID" value="XM_002180388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G067"/>
    <dbReference type="STRING" id="556484.B7G067"/>
    <dbReference type="PaxDb" id="2850-Phatr46136"/>
    <dbReference type="GeneID" id="7201358"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46136"/>
    <dbReference type="eggNOG" id="ENOG502RNN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384747_0_0_1"/>
    <dbReference type="InParanoid" id="B7G067"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF34">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="79713" checksum="AD63C6C1243ED04E" modified="2009-02-10" version="1">MTDNTLDRSRVAGSLYGLLVGDALAMPSHWFYSPEKLRADYGDISGMVAPRPTHAESMVQGMSYTGTWDILHDKARYYTGHQSNTGEGLSQAEKDARRDDHGNYVGHTPDDRVHYHATLKAGQNTANGCLTRLAMRYLAEANEDGDGYDPDEHLRRLQDYMLAPPEPDNDQQLINHNDVYLDVYLRGFFTNASQGKSLRDCALTQRDSWSIGSLDGVVLAIPTIAAYAHEADWYVVGRAVEHHMLTHRSVTVTASLAVLVPLLLSLYRGTDLRTTLDEYMSKMRPPKITGRALADSYVNHHGPGNIPPNEKWRQHMELDDSETTRDLVHRMLDWDDQDVAGFRDRECSRLSTACYCEHALTTVLYLAYKYAEDPEMALLQNVRIGGHSTARGAVLGAILGAAHGVNAVPFVGELCAKESIDQEIAALISTIPSRRKSNLRPYKRDHHHNTATYVSGGCGAQKTDLGRMDPILITVLRDVLGVEISPLTNNVAAALSMVLYFKIAIEAVTWFRLRYSTSLYSKQLLHITLASSIIFWSLFDDSHWSWRLNTLLPSVMMARYIYKGAILKDPEDLEVLTLSRTSSPSDLLFGSLQFAAVLVWLGLYQFRTAEAAIIIAALGVGDGIAPMVGHWYGRHDYQMPLASQKTMEGSVVGVFLGTVVGCYLYMYLLGIPLLPLRIVLAYGGIAAVVEGTAPGNLDNLTVPIAIHFSLDKVQEWLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0H3</accession>
    <name>B7G0H3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180678.1">
        <property type="nucleotide sequence ID" value="XM_002180642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0H3"/>
    <dbReference type="PaxDb" id="2850-Phatr36133"/>
    <dbReference type="GeneID" id="7201184"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36133"/>
    <dbReference type="HOGENOM" id="CLU_1655603_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0H3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="160" mass="18421" checksum="0FA866BAB338763A" modified="2009-02-10" version="1">MRAASTTTASLKDRIKASERLEWRKIRDLGKEAAELELHLLRCDDLKKLAVAYCDFPTIQQTKKKLGFLKARLCEIRSTLSHQEKVLEEMEAILQEEIRVLERRKHQALIEHDYEAASKASNRMLAFLSEYAVVEQTSRACRTFKTKTDLANCGCNVHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0I7</accession>
    <name>B7G0I7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AP1sigma</name>
        <name evidence="8" type="ORF">PHATRDRAFT_36149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180685.1">
        <property type="nucleotide sequence ID" value="XM_002180649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0I7"/>
    <dbReference type="STRING" id="556484.B7G0I7"/>
    <dbReference type="PaxDb" id="2850-Phatr36149"/>
    <dbReference type="GeneID" id="7201294"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36149"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_1_3_1"/>
    <dbReference type="InParanoid" id="B7G0I7"/>
    <dbReference type="OMA" id="WYVATSE"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="22817" checksum="AE876F94118624C6" modified="2009-02-10" version="1">MTTTDIAGEAVETGKAACGWDFIVLMSRQGKIRLSEFFSSYSESDKRRIVRDIQADILPRAPKMCNIIEKGTYKFVYRRYASLYFVVGVPQGLNELIVLEQIHLFVEALDGYFNSVCELDLVFSLHKSLLILFEMFIGGMLCESNKREVLKAIVEAEELVEEMTKPGEDTASQLDDGLSFQEQFQLGRTPGRRQGNSGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0K6</accession>
    <name>B7G0K6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180492.1">
        <property type="nucleotide sequence ID" value="XM_002180456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0K6"/>
    <dbReference type="PaxDb" id="2850-Phatr36168"/>
    <dbReference type="GeneID" id="7201202"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36168"/>
    <dbReference type="eggNOG" id="ENOG502S74G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817533_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0K6"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36869" checksum="DA8501CBD8805DD7" modified="2009-02-10" version="1">MKQAKGLILPIRSCHSLSVDPTLLLLRQSPNVHVAGCFSRQFVRSFQSMIIRSCAPLISFIYTFRWASGAAAWTNTAQVSSTLAMSSTSSPIRLTENDNLPDLPPVSSTAKRIFWVRHGEVVNPGGDRPVYYGAMDVPLSELGQAEARAAGKYLKENTRLSHVFSSPLSRAIYGAEQVALAQSDGSKEGLESVKVLDGFKELDRGDWCGKTKEEIGDDFMRRFDACDELVTPDNGESYNALKARVLKARDAVLQALQPGTSACVVSHLQVTRCVLSDALGIPTDKMVNLKIATASLTCIDYETSMGDDRGNEDGAGITQQVQYQSFKPQAGLATARDGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0S1</accession>
    <name>B7G0S1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_46302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180722.1">
        <property type="nucleotide sequence ID" value="XM_002180686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0S1"/>
    <dbReference type="PaxDb" id="2850-Phatr46302"/>
    <dbReference type="GeneID" id="7201496"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46302"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541313_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0S1"/>
    <dbReference type="OMA" id="CHIVQED"/>
    <dbReference type="OrthoDB" id="45986at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="57712" checksum="C816675BAF9C4E09" modified="2009-02-10" version="1">MSDTADAHRGGIHQDTIREEPTTSYSYSVTHSPSGQSSSSSRPPSHMKNEVSGDHRLSSIHRGESEVEQMAERIETLRANRVVITFPVRVRFLTECRQIAVEQGYDSTKISRTDLEVLRSRIAEEASRTPEVWTRALGVLGFYNVAPALSVVLDRAMETLLLHDDDWLHYQDFSFYYTRVVARWPWLRSEMRVACLIIFAYYFFTPILFCHIVQEDTICVDLGRSYDGWLSSLYFASTTLSTVGYGDLKVEQSPRWRSFIGSLYMIVSIVVAVVAFSAAAGNAFSPLNTYDAWIANFFIGDPHPNDFLYTRVARVKLVKITEIVVQFVLLNLIGVFVTRYYARHSEVEEQQWTWMTSLYWAIQTTTTIGYGDLDMPFQLRWFQIFYLTLSTYFVGNCLGKLGALRAELAEVRRRYVWERRKVTRRFIDELQAYEHDDNVDQFEFLVASLLMLNKISSADVTPIMDKFRELAGGKGFINALDDAEEDPIADEAEAVDADIQGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0T2</accession>
    <name>B7G0T2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180727.1">
        <property type="nucleotide sequence ID" value="XM_002180691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0T2"/>
    <dbReference type="PaxDb" id="2850-Phatr46314"/>
    <dbReference type="GeneID" id="7201383"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46314"/>
    <dbReference type="eggNOG" id="ENOG502STKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053241_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0T2"/>
    <dbReference type="OrthoDB" id="45827at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852835" evidence="1">
        <location>
            <begin position="25"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="405" mass="46647" checksum="2688A92871D0DD65" modified="2009-02-10" version="1">MGLNKQSVAVILLVACSIARTVLHFQTFSNLSLQQVRSTAYSPEVDKRQIRDDTSLFRSGQRFRPKNSGESAATGKCAINLFGLPRAFQSLVLPSLVQSVIRPNALHNCDYFVHYYYLTYEKEGRANSGGRLDPDEILLLKQAVHNVSPNSIVEFRYDQEQAFWDQYQPLIDRIRTVNDTDGHYLYFPWRDKSYLYTLTTDNIVKMWHSIQSAWELMTEHETMKSRRYDRVAMLRSDVVYMTPIDLFQANRQPLRDGAKVAVVPAFGRYPVSDRMIIGPRDAVEIWAAQRFDRLETHVQFVHDKHPGWGMHSERFVKWTIFPAIRETNTTIVEDDFMCFFRARADDTVMIKDCEGNRYQNAAPSIVKNLGKDKIEVLESILGRKCRDRTVALSSSLLQCPAQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G169</accession>
    <name>B7G169_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180983.1">
        <property type="nucleotide sequence ID" value="XM_002180947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G169"/>
    <dbReference type="STRING" id="556484.B7G169"/>
    <dbReference type="PaxDb" id="2850-Phatr36381"/>
    <dbReference type="GeneID" id="7201788"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36381"/>
    <dbReference type="eggNOG" id="ENOG502S3VG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G169"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58416" checksum="A19CA35752A277F8" modified="2009-02-10" version="1">MDEDEGQTIHSDCRKSVAGDRRYSKYLQINFGTRQEYEEIDGPGRTRSPHRSKLVIATLSTLLIAFAIVTLATRLVGLPRLVAESQDSLTNLVPLIAPELDYGEESNEERFQRCQGIDWEQACRNLAGGAGARRRRLVVENDHPAAPFVASDLEEAYLLDVDDPSVVYDEHCLRVYRLDLLQNITFPYHANNLLRAGGNQTMTLFIQHGAMRDADKYFCSFRQLMKSQTYRPFDDILIIAPDFNYKQDVGVLPTDAFWNSSKPTGDWRGGAQSDPECCSSDLTLSSYEILDHMLRILTSKKLYPRMDKISYVGHSAGAQMVQRYALTSRLAAKHDAHNDAVALEFVVANPSSIPHRLGVPTTKKGTEAQYEQWVCADGSYNSWPYGIDLERKEYLPPYILNADMERAVRLYRQRNVIYMVGQNDTCNDGLPTCDSSCWKRLDFLPGEEPCFRNHMDNRCPAMLEGPNRRTRGLQYMDYLREIYGNHTHVLHVIDGVGHNATAMFSSTVGLLELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1I7</accession>
    <name>B7G1I7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181034.1">
        <property type="nucleotide sequence ID" value="XM_002180998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1I7"/>
    <dbReference type="PaxDb" id="2850-Phatr36499"/>
    <dbReference type="GeneID" id="7201603"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36499"/>
    <dbReference type="eggNOG" id="ENOG502SR1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699196_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1I7"/>
    <dbReference type="OrthoDB" id="45460at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="395" mass="45207" checksum="6EE182F17A6A8B3C" modified="2009-02-10" version="1">MRKSRPKVLLLGVSYPKIETLSLFKQRPGCEGISNGGGRISLVERVVDSVKQNILTQMDGRDLARCVATEEHCHVDVYTVSQEKGAIYRDDRHFDGNFNRQTFCRTLKKHFDLIDEGFDQVILDYFWIPAGWNVQHWSRSFFKTTLVNLVKDCVLKLSRDAGHRPGRVYLPFCLHCFKEILASSSTILEHYNVSFLRKGELQQISFWKGTQQIDPDTMQGILAKRRDQEELYCTFGPRDLHEGEDDPFISKGEIADMARKLEDFGMIRFIVLEPLTKTATTRTARQRKNTGRLRGDFVGLVPPPSVKRGFDHLKNTSVCPTTPRKSKLKRVAPNALSLPIRSLTRSERDTRSTQRKAKERRITRAGSPQTVIEGFLKEPAITSQQKQLKPSNLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1V4</accession>
    <name>B7G1V4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180920.1">
        <property type="nucleotide sequence ID" value="XM_002180884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1V4"/>
    <dbReference type="STRING" id="556484.B7G1V4"/>
    <dbReference type="PaxDb" id="2850-Phatr46613"/>
    <dbReference type="GeneID" id="7201740"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46613"/>
    <dbReference type="eggNOG" id="ENOG502S277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352522_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1V4"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050118">
        <property type="entry name" value="Pur/Pyrimidine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864">
        <property type="entry name" value="HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF1">
        <property type="entry name" value="XANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="6">
        <location>
            <begin position="633"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="798" mass="88427" checksum="7432A47663C19C61" modified="2009-02-10" version="1">MRYSSRQPRALRKRSPSTEIDIKMQRSNPASLGVSVMIALAITLATESMHDSVTLLAIPWITGGLPGPWGVVSAWVPTVTFPSTSARTRQNQGQDLAFSSVTTTTCWLAKRNKKQAANQDADDLDRWYGSVNADASPDDVFWEEMQRQRLLAQVGDAVNANLPDPVAAIGATNTNTNSLNNPDSLNTSPYPTTTTTSSSSFVPSPLSSSPRSGSNINLAINTPAARSVEATLSEYEAFSLTDNWLDDELAWMMQEDFVLHEGDPNAHVKSLDEQIEEWELSEDGNMTDEDDLTDSDNAWMQSDDPWDHWGVSEEEQQRALRVSNKADEFLFDSDADDREDSAQQEADFWSRVQGTGIKSRRLERARGNAKAQAFFSREPDDTEGYDRLWVSAIDNVCFKNLVGTFRNYGVQFADNFGDWKDASVQDGLLTIEDVASFKARRVHNVTGLPCIASRTSFEIEPVPELNTGSGSGSPRPSSRSTVINTNPRVTSGYRFNDIGMHVDYVCDALRPLSEPTRVTRFKTCLCYYDGEVEVFDYGVCDCDLLFADSMRTFIPMSQAINEMVKTLELTFGLEYQRWLQSRLSQAMSGIDGASMKLRDRVLKEGKVLPNDIIDVSAFMDSKIDVNLMDECAEELASRFVSQKPSKILTVATTGLVIALPMAKYLQVPVVYARKERNVVMADTYKASYSSKTVGQFRELLVSKSHLDEDDRILIIDDFLSSGASQEALLQLVFDAGATAVGVGVLLEKVYDSGRQSLSGFDIPIHSMCRVASVESGVIQMVEEEGFDLMQKSSQQEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2A0</accession>
    <name>B7G2A0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181341.1">
        <property type="nucleotide sequence ID" value="XM_002181305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2A0"/>
    <dbReference type="PaxDb" id="2850-Phatr47050"/>
    <dbReference type="GeneID" id="7202129"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47050"/>
    <dbReference type="eggNOG" id="ENOG502RZ90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912422_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2A0"/>
    <dbReference type="OrthoDB" id="2150942at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="299" mass="33763" checksum="81CE2606F43B01B9" modified="2009-02-10" version="1">MNAQEFYGQYHGHNVNHLEYVLPFLRESSDRLIWTAGDSSLDNKFWFHDTAPAVGAYKEVLRPPRMKQDVTYWLNALIESRRSNDGSYPKLAAINTAVEATTLNERTFMLTPQDRFLRDNIISEDILLVSIGGNDVALKPSPCTILSMCGYFRHMFGTRVQKYIDALTAKTKPTKILVCMIYFLDETPNPGWAGAALGAMGYNRDPGRLQSFIRKVFLEATTSIQIEGTEVIHVPLFHVLDGKNTNDYVQRVEPSPSGGRKMAEYLLSLCPPGYDRRTKLVTSIYYHAERVSSSDSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2X4</accession>
    <name>B7G2X4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181460.1">
        <property type="nucleotide sequence ID" value="XM_002181424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2X4"/>
    <dbReference type="PaxDb" id="2850-Phatr47229"/>
    <dbReference type="GeneID" id="7201987"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47229"/>
    <dbReference type="eggNOG" id="ENOG502S2NC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059121_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2X4"/>
    <dbReference type="OMA" id="ICVLESF"/>
    <dbReference type="OrthoDB" id="497914at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855329" evidence="2">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="38221" checksum="58531533A3092DDF" modified="2009-02-10" version="1">MRWTIFLIVTLWAEAFCLKTLAFHQSSCSNGMVARTRLGVATRLAARPTMTKVGTFDPLGFASSADRRVASYYRHPATPTTAVETRPRPVATAAVVATTTALVPFEASAQVAGNKFISQGTMNPDNFQPVCPASDGFYRVLQSTTTAVVGEENFVEYGPLISGGLLRIRLELCVVESFFKEAIGPFIQQNGLSWILPLHETVETFLAGSIFALATTFILIGSTKIVTVVLVYMDILVGLPFRLFGGFAYDRAVGKPVTLDVGFGPFKTRIIGPPKPKEGEVTVSEFDLTKASPLGIVLVAVSGTARIIGQVLGFVREVFEAFDLFVGRYLVIGATGYILLKFVHFKIFPDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G313</accession>
    <name>B7G313_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anti-viral guanylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_54726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181708.1">
        <property type="nucleotide sequence ID" value="XM_002181672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G313"/>
    <dbReference type="STRING" id="556484.B7G313"/>
    <dbReference type="PaxDb" id="2850-Phatr54726"/>
    <dbReference type="GeneID" id="7202403"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54726"/>
    <dbReference type="eggNOG" id="KOG2037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021447_2_0_1"/>
    <dbReference type="InParanoid" id="B7G313"/>
    <dbReference type="OMA" id="GQVMFKR"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="7">
        <location>
            <begin position="96"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="589" mass="65803" checksum="AE51CFA506671190" modified="2009-02-10" version="1">MSDTDDSGVLVEHETKTGDQSAPAVVVSDDEVEALTVDEKIDSGPGKEEDDDAAATDDEAKPQALQIVSIGSEKDAYAFKFEEEKLQAILSRVPVGWDVSIVSVVGAFRTGKSFLLSWFLRYLYQVQADQKSDATNTEPWYERIESLGNEGFEWKAGSDRNTTGIWMWSHPHFIETGKEHPTAVLLVDTQGMFDHETTMSLTASIFGFSTLLSSYQIYNVDKRIQEDNLQQLALFSEYARTAVNDGIEESKKEGDDNDLPKPFQKIEFLVRDWQHFEDEEDDEDCEAMEKSMEKYLQTAIADRDAKDLQDTRQQILSCFANVTCYGLCHPGLAVTKKKFSGDVESIQPLFMHLLDRYCKRVFSPDNLEAKVIHGRTLSAAELGSYIQAYADMFASGAKFPTAATLLEATASANNTNAVHLAVTAYKEEMDRIAGPRCSNYVRPEELQEEHGMIRSKALTVFESVATFGSRNSIDQAKGKFLDQVEDNFQVYESLNTGRNPLAGMETYLIPLAIAAVSAILRWFTDLTCSSHSATCRASSEVLHHIYMVVFFFLLIVGATKAQQIKQILTRFRTALEVMSDGSSKNTKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G335</accession>
    <name>B7G335_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_21543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181548.1">
        <property type="nucleotide sequence ID" value="XM_002181512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G335"/>
    <dbReference type="STRING" id="556484.B7G335"/>
    <dbReference type="PaxDb" id="2850-Phatr21543"/>
    <dbReference type="GeneID" id="7202514"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21543"/>
    <dbReference type="eggNOG" id="KOG2683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_2_1"/>
    <dbReference type="InParanoid" id="B7G335"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="66"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="366" mass="40062" checksum="B7203461E7DBF567" modified="2009-02-10" version="1" fragment="single">MMKARSRLTASVSVTAAVSFVSFQQTRAMVSLHGNQALTTSFRMRHTDRLHAVTARPPDPNSLLSATDQQECIDTLLAWFAGKSQILCLTGAGLSTESGIPDYRGNNGSYHRGHKPMVHDQFMKSECQRKRYWGRGMVGWKSFDETAPNAGHVALTELERLGRIGGHDDDLEWTFRSGHRKLSLITQNVDTLHRRAGTKHLIELHGRTDQLECMQCGTKRDRNSFHAELEGLNTDWLNRALATTDNDDMRPDGDAAVGMEDFESVQVPPCQSCGGFMKPSVVFFGDTVPRNRVAQCQTAVEKADGLLVVGSSLAVHSAFRHVRAASKLGVPIAILNVGGTRAEAEGLDVLKIEAPTGQTLEGVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3A4</accession>
    <name>B7G3A4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_14067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181583.1">
        <property type="nucleotide sequence ID" value="XM_002181547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3A4"/>
    <dbReference type="STRING" id="556484.B7G3A4"/>
    <dbReference type="PaxDb" id="2850-Phatr14067"/>
    <dbReference type="GeneID" id="7202448"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14067"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3A4"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="5">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="104"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30613" checksum="B6F815EC2E5E39A3" modified="2009-02-10" version="1" fragment="single">MAPSSLVRLVKPYLYTFRSNAKFRWFGRTILDVYVSEFGSYPESYYRTAIQQGRIRVGNEKVDVAYTIRSNDVLTHTVHRHEPAVAVSQPQAPFVKVVANSETWLVVDKPGTMPVHPSGAYHLNSLLPILENTYGKLYPIHRLDRLTSGLVILGKTPEAARQLGKAIKERDSCTKLYIARVRGRFPFNCASHVPNLSSHKSYPPRYGEWSVLQDMDGKKDMKAAETSFALLKFDAKSDSSVVLCRPATGRTHQIRLHLQYLGHPIANDPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3N4</accession>
    <name>B7G3N4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181645.1">
        <property type="nucleotide sequence ID" value="XM_002181609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3N4"/>
    <dbReference type="PaxDb" id="2850-Phatr47518"/>
    <dbReference type="GeneID" id="7202292"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47518"/>
    <dbReference type="eggNOG" id="ENOG502RYM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334790_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3N4"/>
    <dbReference type="OrthoDB" id="46714at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="5">
        <location>
            <begin position="616"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="953" mass="108230" checksum="761E2F6A878B4E95" modified="2009-02-10" version="1">METSVCNSSSNPRYGPLEPRRRKTNIQRMLRQESGGRASTYRLRITQPCPILLLLLLLIAQSSVFVWYHTCDEAFFVDRPINEQGIPAFYKPSEHDFCKSFVRHGLFSLLGNGMVPNDGKIENDLFNTAAHTPKDRTTLSASRRASADLKMIKATIAGEPTKATGPEDSSVSRDFMNTSASKEEHLEVYGGVPGKNQHTDEAIQPVSMLLLRAVGNSLPPRHSAEQTLRNLDFVLTYEEAFPNLSRHWFLNRLVDPQVEQQVVQRLQQANESYTIIPFDLKSYDSHVYRFDLLDFPDQIHSTYSYNTYTGFFLGLNAEDRIMRDKLVYTANVNGVRNEMLNYGRHLSSAEYILPFDGNCFLARNAWEAMQRNIQHNPAAKYFAVPMDRLVEENAALLSGSYKPNPVEEPQIIFHRTSIANFNPNLPYGRRNKVDLLRRLGIKGIWENNEGNKWDVILEATNPVAEIEANVIEMTGTAGWISRLYSGNKNAELTDAGASTTRVRMRRTAISTLLDRLDLRAAVTLYNFTSNTMLFYDEQQLYQSHLLWKNGQLQNPMINSLMEKAAQSLNEGPWSVVDKRSFGCGPSLSCRDYYNPWPYMWPQRNESGSIDWTREFVMNNGEILPGSVLYTEGSEHFDYTRLESMQRNTTVLALAYAISANQSYAEKAAANLRVWFLEPGTRMNPNLSYTQVAWVGNPPQWRRKAFGTIEMSGVYFFLDAVRIVEGSGALSILEIHNLRRWFREYLHWLYMSNGRKEASEFDPNGGIPEVFAPNHIGLNFDIQLASVAAYCGNLSLAVRTIHRAVSRLDAHVNSTGAMPKEQRVGSCEHFTALALNGWSVAARVASSIGIDYWRRFRVANRNISKLCLAMEYGNPLLDNRETCAGDGAPIDPSRWWPLFFEAKSRCPHLETRYLVQNERDPPEHSDFPSHHNLISGSNMPYSGVAPFWNLNLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3T1</accession>
    <name>B7G3T1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181665.1">
        <property type="nucleotide sequence ID" value="XM_002181629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3T1"/>
    <dbReference type="STRING" id="556484.B7G3T1"/>
    <dbReference type="PaxDb" id="2850-Phatr47270"/>
    <dbReference type="GeneID" id="7202357"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47270"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013303_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3T1"/>
    <dbReference type="OrthoDB" id="3979788at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF6">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="897" mass="99039" checksum="A61CC74AD560EE17" modified="2009-02-10" version="1">MATPDQILAASRYRAGGGALFTSSKCPPGPGLENSCQLPFGFIYTPLSPPDNIQVVPIHDENLPPVICLTCLSYLNLYCDVDETTGVWTCALCGCKNAAPPESFHNGTLSPILISPIVEFRQPIAEAHDRVNTISVVVVMDANLPRAEAQAVGSALQAILPEMADAKTRINLGFIVFSKHVSIYQLNSTGVASADIFSTHEGLTEKHLESRQYLTEIGQDGSLECMWRCLSAVYGVVLDNEEGSEINVSKGKQLSRLEQLKQRKETRMRKELERDDDDPDVVVKSPWVLAKENSASRHPLRCTGEAIQCAIDLVASPSNVDLIESRILVFTNGCPNYGDGSVVYDDRDMTTTARARPTADVVDPLKLSGAVEYFSIIAKAAVEGGIAIDVCCSGASELCLPVFQALVEPSSGYVLPHETFAGPHLKHNMNHFLKETNMTMAACSESQAEKSKSLAPSGCTIDIRMPSFVNPTHLVGPGEILDDFKGLLLNERSAFAAGCKLAARIGMRTNHLPQKDFVDDAVTRLSMGRKDPLSTFSVMLEINNFFQKDAFAFVQCIARFVDRRGQILITRVFSHRISIANDVGEFLDSIDEEVVPVVLGKEAVYRSMYGREIDARNEDETEVATSDELDDLAYDAQKDLDATIHRISVAFRLLGLEQGNRGLDLTEEGGIRTVGSSIDFAFPPELSDALRRLYHLRRGPLLSPGPMRSDDDRAQIRSLFLRLPLEDCLCMCAPSLWRTEVTPECKSDSVEWIAVPPESLALWDKTAIVADCYHSLFIWFGRGVPESFFDSIRQQARTYLLDRSVIRFPMAEIYTVSEGESMDRRFTALLAPSYGDPVDHQVANFPALGQLSPQELESLRCKFRFYDPTSDPSFRTWFWDVASATSSSKEFGLSLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4I5</accession>
    <name>B7G4I5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182078.1">
        <property type="nucleotide sequence ID" value="XM_002182042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4I5"/>
    <dbReference type="PaxDb" id="2850-Phatr47680"/>
    <dbReference type="GeneID" id="7202693"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47680"/>
    <dbReference type="HOGENOM" id="CLU_1762361_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4I5"/>
    <dbReference type="OrthoDB" id="53916at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="148" mass="16945" checksum="942CC0CC218CB8D1" modified="2009-02-10" version="1">MMREDEDEALVSAKGSAYKLDWVERTVQLAQTCNQILSANACRLCYVYVDKQVEYETRQQQPYEGNGRAANSNRSPHPLPGALERVWTQTATSPHFSMEVDFYRQLLFDEDSVVDAVSERDPDSKDEEDDETEEIDETLRAIATQCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4J8</accession>
    <name>B7G4J8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyrophosphate-dependent phosphofructose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PFK1</name>
        <name evidence="13" type="ORF">PHATRDRAFT_47690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182086.1">
        <property type="nucleotide sequence ID" value="XM_002182050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4J8"/>
    <dbReference type="STRING" id="556484.B7G4J8"/>
    <dbReference type="PaxDb" id="2850-Phatr14284"/>
    <dbReference type="GeneID" id="7202698"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47690"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_7_4_1"/>
    <dbReference type="InParanoid" id="B7G4J8"/>
    <dbReference type="OMA" id="ERMGINM"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050929">
        <property type="entry name" value="PFKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005301">
        <property type="entry name" value="PRK06830.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45770">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="564" mass="62266" checksum="308961F93477DA52" modified="2009-02-10" version="1">MSKEHGQSLWYATALWLTTVVVTAAATYTVTKRREDAKQTAIVYRQYQRDKMLKEKTAEARKKSYEPPSGSLLDDLTLDKIYLWECEDLRKKFPSAMTENTMKCKATPAPLIRSPTLRRSYTAELDESDFETAEKITRYNKLITDHECILADIVRKPNMHTHTVSYMRAGPRRHLHFDPQSVNAAIVTCGGLCPGLNNVIREITKTLHQIYGIEGTVYGIQGGFRGFYDPAPHLQPVILTPELVENIHHEGGTVLGSSRGGFDIEKIRNFIHKHKINNLYVIGGDGTHRGAFRIHEDCMEHGMNVAVAGIPKTIDNDVDYIDHSFGFNSAVEAAQYAIRSAKTEAVCNLPNGIGIVKLMGRSAGFIAAHATMASSDVDLCLVPEVPTVLEGPNGCLPHLMRRVKQQGYAVVVVAEGAGEEVLGISAEADASGNKKLPAIGEFMKQAVTDFFAKHGDVATVKYIDPSYTVRSVPANAADSLYCMQLAQNAVHGAMAGFTGFSVGLCNNRMVWLPIPELVATSPRSMNPRGRTWERVLALTRQPNTVQPLKKGEKDKYDSHSPMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5F4</accession>
    <name>B7G5F4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_38277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182403.1">
        <property type="nucleotide sequence ID" value="XM_002182367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5F4"/>
    <dbReference type="PaxDb" id="2850-Phatr38277"/>
    <dbReference type="GeneID" id="7203191"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38277"/>
    <dbReference type="HOGENOM" id="CLU_373200_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5F4"/>
    <dbReference type="OrthoDB" id="199120at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="745" mass="81733" checksum="F4D83C3D89C4BEB8" modified="2009-02-10" version="1">MSNQQKDGTPMAGSDQVSLVKDGLALQNHDSNHLPFFADATLDLEEAHDIADTPEPTRPVTRPNKLQIAAAVEQIPMPTLHFLESPTADSFADANVDPRTVADATSTGSSIPTNSISRESPDDKSTFARITSLETAYPSMSRTQHSVPRWPRDLPWAIAFVLFVPTGLLWPILTQTEANESSHAITFHPLSTASLHGLFWSALASVLLSRALYRTPSGGEGDDARFHIAQLLTLAAPVAVCVHVALVLLILLACPHAALAALVPAWFAVKDMYLFRRWKQRRSAQFNGPTESPSTSAFSAVQSVGGTRQAFFQALMGMTLDILSRSLRRASFYRVLSGVLIVQCITVWLWRWALLAALTISGSSSPFGAHSKGIIFMVAFVAGKWATGTVARLLSLLACGGVTSWVAVQQELQSVNNNPMFYSQGSNSNSRNGTYDADRDENIGYSEDETNDMPEAYRTVDASVYQSVLSIEDDLDDDYELDDDEFMEAPSRREHSRRRENAQPQSTVKSILLVGLSISFGSVAQCGLVGGLAQFMWSQLRVVEAARTVLSEVRRDSGFHNMTIGSNEAGFFGKMCKCMHNMARKFVRNHSDLAMTHVAAFYKSYQKAARDVSTLIDESDSHFDSDTSPQQPQTGVEPILHDDITTHMAACVGGSISGLIVIFTTSVLLYQRDQRQDPGSDLEVVENMLVSFALFYTLLFTVLEPIRASIKAVHLGFPRIHSDDKVCLAIFLSSNQQVLLARLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5F6</accession>
    <name>B7G5F6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_56595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182240.1">
        <property type="nucleotide sequence ID" value="XM_002182204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5F6"/>
    <dbReference type="STRING" id="556484.B7G5F6"/>
    <dbReference type="PaxDb" id="2850-Phatr14426"/>
    <dbReference type="GeneID" id="7203129"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56595"/>
    <dbReference type="eggNOG" id="ENOG502QRFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_1"/>
    <dbReference type="InParanoid" id="B7G5F6"/>
    <dbReference type="OrthoDB" id="70257at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048285">
        <property type="term" value="P:organelle fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000023">
        <property type="entry name" value="Cell division protein FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0717">Septation</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855790" description="Cell division protein FtsZ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="267"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="48479" checksum="0259B029F99030FE" modified="2009-02-10" version="1">MSASNRYTALLLSISCLLHASLAFSSRSLSSQTSTSSHTLLHSDLYNGGPPLFNQGAGEQANVYTQPGAPCVIKVIGVGGGGGNAVNRMIQTRIEGVSFWALNTDAQALSKSLAPNVLNIGRQLTRGLGAGGDPGVGRGAGEENIIEMQHICDNTDLVFITAGMGGGTGSGAAPVLAKIAKQDCGCLTVGVVTKPFAFEGRKRMMQAEAAIEELRKNVDTLIVVSNDKLLRIVPDNTPVTEAFLVADDILRQGVVGISEIILKTGLVNVDFADVRAVMKDAGTALMGVGTGVGKNRASDAALAAISSPLLDFPIQRAKRIVFNIVGGADMGLQEINEASEVIYENADDNANIIFGALVDPQMDGQISITVLACDFDAQPADVYSITEPIGVGIDERNPNFYKERRKSTQSPLGPDASVEETRVAITRGFKKAVDPDEPVADEEDAQSGFRNFLKRFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5P4</accession>
    <name>B7G5P4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182285.1">
        <property type="nucleotide sequence ID" value="XM_002182249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5P4"/>
    <dbReference type="PaxDb" id="2850-Phatr48017"/>
    <dbReference type="GeneID" id="7203243"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48017"/>
    <dbReference type="HOGENOM" id="CLU_898528_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5P4"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="310" mass="34485" checksum="DF95B3639B4AD36A" modified="2009-02-10" version="1">MLPFSRDNIEQDQVFLSRWLVSSQSNLNEIGKRASTDASVDTKGSTADTSECSQSFDDTISEVSCELGICFALQLSVSDFAEAEFHSSATIGSPESLHEHQAYSTTCSTNHKKQETEDRSTFTFEQQLAHGVAAMQASKFQCAVAFFERASDETNGVPRGERIPLRRARALHLVSLAASQLKNLDLAHNAAQESYLIRLQSYGPLHIDTIASFSNLGYIYIELNEVGKAAWCLAQVLKALRAVFGYEHESVGTTATTLAAIYLRLERPEQAKRCYLYALETYRALGWDKTRDGLEEELYKLGLSETRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5T3</accession>
    <name>B7G5T3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase E1 component domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_38407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182597.1">
        <property type="nucleotide sequence ID" value="XM_002182561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5T3"/>
    <dbReference type="STRING" id="556484.B7G5T3"/>
    <dbReference type="PaxDb" id="2850-Phatr38407"/>
    <dbReference type="GeneID" id="7203406"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38407"/>
    <dbReference type="eggNOG" id="KOG0450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5T3"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="219" mass="24319" checksum="F9A36B604C7F49E8" modified="2009-02-10" version="1">MKFLTLHPAANSFLFTTNWAAKATLGFDIKGDQHEVILSQRGFVGICFYSQAAEEISDNEEPHEPLFSGKAAGEQALGLAQCILEKKMFSLFGHVTKPVSLKKIRNVLPILLHGDATFAGQGVVYETMQMAEVPDFDVGGTIHAFTCPIFHCNGNDPLAVSTALETAVEWRHEWGMDVIIEMVCYRCNGHNKLDQPAFTQPKLYKEISQHPPTLEIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G691</accession>
    <name>B7G691_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182684.1">
        <property type="nucleotide sequence ID" value="XM_002182648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G691"/>
    <dbReference type="PaxDb" id="2850-Phatr48181"/>
    <dbReference type="GeneID" id="7203508"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48181"/>
    <dbReference type="HOGENOM" id="CLU_898530_0_0_1"/>
    <dbReference type="InParanoid" id="B7G691"/>
    <dbReference type="OrthoDB" id="47441at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="348" mass="38265" checksum="98CF66FF9A9200F8" modified="2009-02-10" version="1">MKPTCLLLSSFQSGNNKSVQLLLPNPSIYETGIAAMKGAWAQVVDQDARDSFEQLSSDGVIRESVLQNASNGSTLTFALFNNLQDPIWKKHNFKAKEFVQAVGPALENVHEILGKIRNEMITTVPGEKAAIESTLKHSIEEILANQVSIGHEPETLLGKNELHVQAKENPNSLAAWATKILTPACLEAFYYTSKFDLLSALPKSHKVFEEGSCNISEVAILNARAMAVTDKTSSESAPVIKQRGVAAQIDVLYEVSHTFNETNMILHDDPNKDASESCSDPENKSSPELASEEESVPESLIHTNLTVAVFEGWLHGGPDNILKWRIAGFRQPFEFPFSPPTINRKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G693</accession>
    <name>B7G693_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182685.1">
        <property type="nucleotide sequence ID" value="XM_002182649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G693"/>
    <dbReference type="PaxDb" id="2850-Phatr48183"/>
    <dbReference type="GeneID" id="7203509"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48183"/>
    <dbReference type="HOGENOM" id="CLU_1059455_0_0_1"/>
    <dbReference type="InParanoid" id="B7G693"/>
    <dbReference type="OrthoDB" id="55282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="254" mass="27925" checksum="87D84B63BD085302" modified="2009-02-10" version="1">MDSSDGFRNHDYRGAIALNNMGVSLLEQKAYLEAMETLKDSVIVMKVAFQQESCTNFRDTSILVEEKLDRACQRLSTQRLEADPTLIEGLRHDGGFATLQSLVTKQDPILSESLFPVRIEQLDDHEDIENSLKTAIIMHNFSIAHFCMSKTPVNDEVRARLVEGGLRLASVSYGILSKMMSGGKNLLYELILRDTNVFVVAIAVLNSLVQMLIALGSLGEAERCSAKLHQLGALVKQIDSPEITQSNTVAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G700</accession>
    <name>B7G700_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_29532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182946.1">
        <property type="nucleotide sequence ID" value="XM_002182910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G700"/>
    <dbReference type="STRING" id="556484.B7G700"/>
    <dbReference type="PaxDb" id="2850-Phatr29532"/>
    <dbReference type="GeneID" id="7203592"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29532"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_5_1_1"/>
    <dbReference type="InParanoid" id="B7G700"/>
    <dbReference type="OrthoDB" id="45555at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="237" mass="25949" checksum="71381FDDA5E39EC9" modified="2009-02-10" version="1" fragment="single">MFARAMELYGDDDSQRELGRVSRMLRVQYRMHKLIADWASQALYGGALQTATNVQSRTLAQLTGCLDEEEDCFGAASNAALLLIDTTGCNMHESVNAAGSRFNEGEAQIVRQHVQTLLDMGVRQEQIAIISPYNGQVELLRSALLPDAPHLEIRSVDGFQGGEREAVVLSLVRSSARGGVDGIGFLGDNRRLNVAVTRAKRHCCVVCDSGTVSKSPFIRGLVDWIEEHGETRAALEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G721</accession>
    <name>B7G721_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182826.1">
        <property type="nucleotide sequence ID" value="XM_002182790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G721"/>
    <dbReference type="STRING" id="556484.B7G721"/>
    <dbReference type="PaxDb" id="2850-Phatr48417"/>
    <dbReference type="GeneID" id="7203668"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48417"/>
    <dbReference type="eggNOG" id="ENOG502QW74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_5_1_1"/>
    <dbReference type="InParanoid" id="B7G721"/>
    <dbReference type="OMA" id="LRKPPNH"/>
    <dbReference type="OrthoDB" id="197550at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="333"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="455" mass="50792" checksum="62BA4301478CAB53" modified="2009-02-10" version="1">MGKSKKRKHALFHAATKVLDEEQSNGKDPGDDLGSVVSAADLQTTIDTLQILTEHGELLQGRAFKDLRRALHPIIVAQMRSYDQGTDYKIKATHALQNLKWSDALAALQGCRDFQQIPKQGTIQRWVRDCDQAPTECKITLLNAILQVNGHSSNNKHDVGLVLAERLKDGNSSHAANGGLLVLDSWRVPGHASSSKIEKEEVIKFKVPLSTNIIFQEKASERKPPNEYDLLLHSVTPDSIQWSDPPPTINKHIVPFVDDVFLLDHVLTRSECNQLRSVATMLGYRPDHPVTVDKPTGIDSCEWLVDASIMDPLNERVKSLLPPIMKESAVVHSINSRWRFFRYSQDSVYRPHIDGSWPESRINEKGEYEYDESGSVKSYLTFLIYLNDDFEGGETLFYIPSSQGMSARGVVPKAGAVLVFPQGNTASLIHEGSAVANGTKYVVRTDVLYRVKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G737</accession>
    <name>B7G737_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182836.1">
        <property type="nucleotide sequence ID" value="XM_002182800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G737"/>
    <dbReference type="PaxDb" id="2850-Phatr38881"/>
    <dbReference type="GeneID" id="7203674"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38881"/>
    <dbReference type="eggNOG" id="ENOG502SFCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399822_0_0_1"/>
    <dbReference type="InParanoid" id="B7G737"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72033" checksum="4D90B04BE699C6D9" modified="2009-02-10" version="1">MVVDYLGSEFQAFRTQNITSRSRLDNSQSLSTFTSLPSLRCFSSAAANGKAETSSADSATEFNAATVASKKRLSMLRRRRRHIKASKQKLSKQKNAVEYVPMVPRKRDAYLALFDSLASHHALSCIDEALDILRKLAKSIANSVVPLITAFASTLHTSNSSQVLQIQILEFLLSTERKAKEIPKGEVESTGAGEERETYFKKDHKSEETGATVVQVYKHARERALEQELLWKSKFKVSDRVAIQRLRLQQHREKSDDDLEKDAVDLVDFLKDSLTAHQFDMLAKLFQNYTSTNDGIDEDSTAKNGEEREPATSSRKRVMRKLSTKLERATGTHFALVATKVASFFYMDDIEVSEDDKVLKAKEKWKSQRDKFADILLRLQELLVECMEEIRSEMSAAGTADPSLENIVAGIRKNSDLDPPTEPTTKPSLPKIRQHHLVFDAMVLHEATEEWYHTDAAVSVFNLRPSENIVFVDNLPIDMSISELEDLYQRCGTLQSVQIFNQRPDLDPGPLNRAQLRDRVKRQVGSVSLRQKRWQRPRTPVYGILQFEDSDGYRAAVDDSLRTFGIVVRKHPMRSIRASEMTRLYVESVPAGIPGIDFEYMLSQLLKPEVFVSLDVGQDKSAIYFNKETKEVDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7E0</accession>
    <name>B7G7E0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183258.1">
        <property type="nucleotide sequence ID" value="XM_002183222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7E0"/>
    <dbReference type="PaxDb" id="2850-Phatr48693"/>
    <dbReference type="GeneID" id="7194678"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48693"/>
    <dbReference type="HOGENOM" id="CLU_664753_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7E0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="414" mass="45106" checksum="13EEF125CD647A78" modified="2009-02-10" version="1">MILPHPSPPQVPARRTPTRSVGTRSTIHNQSQASTCRSRSLPSHQTPLQTLVGVAPMHCESDDVAVNANREESIFDPRITDARNGTEFEAAPSLEDPMQVDDDTVQSFLVKTLPLVTPASPTTVAVRSPVTRAPTTDAIDAINPSIGAAVTTTTILHNNNTIRALSPHPFTQWVDYLPSLPQSSHEATVTTLTTPTRQHTTASATVKRVSLDATESHLHDNNNTTLGCHHDDEDLHEMQLDVWDDAAASEITSTSDEFYNPLVPHSLLLSHDVQLQHELLLDDATSISSQSLHTPLPPTSGGRTQAETPHHAEDLRMRRQSLAASMQASQQSRKVLLSAHVQQRANLARVLSSIEKSSRQIQTGILTTDASSEHDGHYPSSTTTTLPDNDEDVVLEDDAVLCFPVEELLNDPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G856</accession>
    <name>B7G856_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183417.1">
        <property type="nucleotide sequence ID" value="XM_002183381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G856"/>
    <dbReference type="PaxDb" id="2850-Phatr48724"/>
    <dbReference type="GeneID" id="7195192"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48724"/>
    <dbReference type="HOGENOM" id="CLU_420640_0_0_1"/>
    <dbReference type="InParanoid" id="B7G856"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="652" mass="71960" checksum="C7C51C9FF197E2C3" modified="2009-02-10" version="1">MSTSSAQLITTPAVHLLPPPTDPEIIHTLRMLASPGSDNNNDDDDETSLASPTVEEWAPSSVVRIVAQETDTRVRHRKGAVTRATARSSLVTVTPTERSDTNLPTTPARVDPTKEASERAWASTEPQRMTTVPDDDSTLERSQGPRVRQAPTLTTTVTRASVSQRTKQDGRRSSTNGSFRPKVSVSRRRYSLPHKNRAPVDRRSSLDHNHRLDRTNSPLRPQNIFQTTGVSRRPNDYDRLLQMEISLRDAVPVRHQAPFQKGWSVEHGVRSPTVHRSTREQHHHKSWREDSPRNAQPKLVGGDTGTPVVPRGENAETFLSIPILAQSNDRPSNTHLPSPILGDIPQLVHQPSKTDGSHRNLPPSESSLGTVLRAKDTGSPTEEDVSTATTDVTLSTTSSSRAKESAPVETEPAPLAARAHSLLSQIKQRTVANKHRVSHIREHRRRTEVFEAELNRNKTKNGIESGDDAKPITAVVYAQRLFQTEGRLYRSQSEGLILKEAVLNLSSLLREKDDRLSRLEFHRAVRDEQIKASGMVHAAVCITELEQKLAECNLKISTLTATIDQQTAQNELYEARSKMAQHLNVDPECLSSIQKFLTKQDSDKSNDTLDETLSHASTPPPVARGASAAAESSTGSVTSSELTISPLRSDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L2</accession>
    <name>B7G8L2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183491.1">
        <property type="nucleotide sequence ID" value="XM_002183455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L2"/>
    <dbReference type="STRING" id="556484.B7G8L2"/>
    <dbReference type="PaxDb" id="2850-Phatr15320"/>
    <dbReference type="GeneID" id="7194940"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15320"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G8L2"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="32005" checksum="424107490FD82A3B" modified="2009-02-10" version="1" fragment="single">AGLTLGLLGLDPLLLLIKERAGRSEKERRMARNLLPLVQQHHRLLVTLLLMNSIANEALPIFLEGLLSPTVAVLVSVTLVLFFGEIIPSAIFTGPNQLQIANRLAPLVKAAMCVLGPIAIPIAKLLDWFLHDDDGESLSAYNRGELSALILLHEMSAPVQSGRPTYERSTSIHVDEVTMVEGALQMKTKVAVDVYTPLRKAFLLSDDTLLTEKEIVQIYASGYSRIPIYRKDPEDPTYKSNVIGVLITKQLIVVNSRDKRPLHTLPLYTPRCVSHDMSLVDLLNQFQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8P1</accession>
    <name>B7G8P1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_22819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183376.1">
        <property type="nucleotide sequence ID" value="XM_002183340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8P1"/>
    <dbReference type="STRING" id="556484.B7G8P1"/>
    <dbReference type="PaxDb" id="2850-Phatr22819"/>
    <dbReference type="GeneID" id="7195158"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22819"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_4_1_1"/>
    <dbReference type="InParanoid" id="B7G8P1"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="20700" checksum="A28F0AF7019A7F28" modified="2009-02-10" version="1">MSGLWARYNSMLDAQPLLTKALTSMTGFSLGDILAQCFIEEGDKGYDPMRTFRMGSFGFLLHGTTGHYFYGFLDSKLPGTAPMTVASKVAIDQTIWNPIFGCMFFGYLNLMEGKSLDDYTTKIKTDLKTAVMGSWAVWVPAHTINFAFVPPAQRLLYINTIQIGYNVFLSFLGNKSVEEEPKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9C3</accession>
    <name>B7G9C3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183749.1">
        <property type="nucleotide sequence ID" value="XM_002183713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9C3"/>
    <dbReference type="STRING" id="556484.B7G9C3"/>
    <dbReference type="PaxDb" id="2850-Phatr49054"/>
    <dbReference type="GeneID" id="7195424"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49054"/>
    <dbReference type="eggNOG" id="KOG0510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339351_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9C3"/>
    <dbReference type="OMA" id="IGNEMRY"/>
    <dbReference type="OrthoDB" id="39446at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="399"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="853" mass="96158" checksum="625CC9B33585BBC2" modified="2009-02-10" version="1">MSRPYDGQTPAEQATFAREELMHLDEESMMDDYNDDETENNQSFLNLLPEDDEAGNDDPAQLFAILEDAINQTAKQTGDTGRALTAVEQQQKRENAEHTWDRVRRWMWAHPQVEQRQAAAFIRGQADATALHLMCKLHNPPDDIIQAIVDSAVDVVSWTDAHGWLPLHHACANGVSPETMKVLVDAYPAGKLQQDNMRRTPLHFYATRNSDSTVIMTTNTELLADDGAAELTDRGGMLPMHYACAYGTDPAVLEVLAQVYPASLTAKENKGRTPMHLAMVNAHRDASPNVIHFLLEYAESRATVNVRDQDGYLPLHLLALGLKGYTADESTKRSNVSACLSMYMDAEPQAAADFLTAIQDLPDWLQDTAVVSKHVRNVLNYKIVQPFPTSILMLDGYFLIVLIVCFAFSTKYYIDFLFEPESNKTDIDIYIVFLFIGASYFLMRELVQVASLVSLGSFSSWWSDAANWLDVGVITMVYYYAICMSMDSPVDRNLFRSGAAFGQGILYVAVIVYLKSTYVDFAVFVGGVLYVVQRLTAFLTAVGVILLAFAQMFYFIYVDGEMCTNRLQPDDLNYDADLDCRFSHCSFEESLLRVYSMMMGEIGDEKRYSAGPTSLVAQILYVGYAFLVVILLSNVLIAIVTDSYEIIQNDRAAIVFWTNRLDFVAEMDAITYGAQRRLGCFRKKKAPMQVEEIPNAPGLVSDDYNDRNGSSDFFRYGWQQVMLLFDANLYEEIDPIESLVYNIFRIACIVFVIPLWLIMGAATAGWLWPPQVREALFCQKGTTTSRSEIERKKLEQLRTIQTDLTSLKSDIVREMTSDRDEMIRMKLEVEGVQAEVLSDLIQVRELITSLLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9D0</accession>
    <name>B7G9D0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteinase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183753.1">
        <property type="nucleotide sequence ID" value="XM_002183717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9D0"/>
    <dbReference type="PaxDb" id="2850-Phatr49059"/>
    <dbReference type="GeneID" id="7195306"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49059"/>
    <dbReference type="HOGENOM" id="CLU_2066030_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9D0"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091:SF29">
        <property type="entry name" value="SUBTILISIN INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00292">
        <property type="entry name" value="POTATOINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853102" evidence="4">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="12986" checksum="15518EA3FB35046E" modified="2009-02-10" version="1">MAASKMWIAVVVIVVGTILATAQVQNRGNKVSSKTNAAMVPMPKIGGGDEGQNKEGPWPQCVGWTGEKCKTWIESFAEDLRGNVYILPEDSMMTMDFRTDRVRILVDGNDLVSQTPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9W7</accession>
    <name>B7G9W7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183848.1">
        <property type="nucleotide sequence ID" value="XM_002183812.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr49227"/>
    <dbReference type="GeneID" id="7195693"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49227"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241885_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9W7"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1182"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1297"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1496"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1531"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1675" mass="190922" checksum="A82F3E85CABAB5AB" modified="2009-02-10" version="1">MKPKVRIIDPEEFPSDTDENLEIVPLTPRDSAETTESFHTHATSSYLHFFRSDQLPSARSHRSETPLCPTSEQRHSVLLDEEEDGEYEDLDDISPSPRKYVPTQYMLSEPPRHRTPASCRSLSSVSSACSVESSRLSILSSASHLFGESIVNFDQRDIETGSVASSYVLSPGRTVISPTSRGADRNIIWWREMSDNLITIARGLREDLPHLIESVWPRHHQTRLPLSPRSRNLADINFLTSQHKSKVQALVFPEEEYFDFCLVLKPQETYAFWASLLDFRVEILGQERVDQMNEALESSSTNNTRSNTPSSDRPSTPRSYSDDGSEARDVVDSVIATPPTTGMHRRRANVTGKSQTTPGQSTSGSPMPTPYESATMTRSKMSMVSPGLYSVADSSRVSQGMTRLSMFERAIHNGSSTAFTPESCLRRSSTVALDNALVESATPNTVHRRRWGNHTASQTPNMMSPPIRSLTRGSSTVRRSTTIRSTAFPSSGNGTEITLGVAEKTSPRTVNEIRIEDIPNQVIPRGIAAHTNGMLHFLSALKRGIVVRRHRPGKEAVFSKIVSSDGGDTIQYIFVEKEDGMNAFKEQRVRYNNVSADEVENTQPWSYEQHSLESDTTRPNHDFSVPDYVAAKQYREKMRREEGLRKNVKTLATKVVRSGAAKAADIIAVHPGQHEDPRSSERNLGSTSLRRSNCSFSAPHTFSLVLRTSQSFGRNREMSLDEWEQKWYSGEGNESLFRYVDIEAATKGEYWLLFRGFLLLHRDAAVGRFAEQRAAGIGSHYSRLEVEQREQADLEAHNRLHRDEFHEPVTVGCLEKLIVKWRQLDTTYMEGFTMAGALPPPSDYFLGFKSAGTSIWSRLRQAGLETQRVYSLDPRRVLIKVRCPSDRLMDVAEVLKLKLRSSEGGFAPFREDMMDMFKSTDDLTETPHIDNVHSFHFRSSIRQSIIDFIISSRIRDSGAELGQTTDVGKMIQSRVPLHMRAKVNSIYQTWTHFWKEENWTGRDGCSLSHESFSDTSKGVEHDRFSFVSKSTCDTESGDSSEAAVPHLFVRIFKGCFYQPLDSIEQYFGEKVAFYFAWLQHTAGHLVWLSIFGFIMFLLQVGSGSWDHPLRPFYSVMVMIWTFTVLINWKKRANYLAYRWGTLDYKEQETTRPEFKGDYMRDEVTGEWVVTYPKWKRWVKYSISFPLTLLFTAGSLVLILWVHANRDLTLARYLDQKANPGSEKFQFNFAISAIGKEAAITDVQLSREHILDPTFWFITIGMPALLGLCQPLLNLLLMKLSLMLNDFENYRTESEYRTYLIIKVISFRFVCYFAHLYYYAFVSVGSTQAIENGILRVGTGVFVYTTVAHWWQIFLQIYFPILIRKLRMYYRDKRLCEELRDLELDEEEVREMASRGLRVNLKERQVRLVNKRLLVEQAQDDIWLEVMLPEHNSFPEYIQAVVLFTYVSCFSAVLPITPLIVLFNYLVSMRLDAFKVCKGRRRPLAEKTGGIGIWEHVLHIVAVISVLTNCWMMGFTNALFVKIGESIGEVGLFAIIVVWEHVMLLIKYVMETSISPLPKIVKDAIKREQFELDQQRNTSMRLRQGRRSQHDRESVGEDRTQGVWRNVPSIGRASALHPIHSEDQESVRSVSRALSRAPTLDLGESSIEQSMIDSVRTPKVGKSDVEQGLEKTLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9W9</accession>
    <name>B7G9W9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183849.1">
        <property type="nucleotide sequence ID" value="XM_002183813.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr49228"/>
    <dbReference type="GeneID" id="7195529"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49228"/>
    <dbReference type="eggNOG" id="ENOG502S6FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234108_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9W9"/>
    <dbReference type="OrthoDB" id="71430at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="3">
        <location>
            <begin position="369"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1761" mass="195605" checksum="E7946BF5F2D23AA2" modified="2009-02-10" version="1">MFTLWHRSHQRSSSPILPMTDPQVLAASSALSSPKDSTTDAIGTHSRGLVQPRPASDGSSSNNGINGTSASGDAAVFRDSPVARVSSSGSNGKKQAAKVFKPLRTVTRRLAGRFLKTDYGSTAHSLVENAERSRSSRGPSVRRTRVTRNAKGKALASRKNLDAGKEHLLPHRADSLEEEEEIVSSDASEGLFIGNRHSESFPSHHPISSQDTVLWFELMLRQLALLLIVYQIGARFPLYTANSAKVLEYVSVAWLTCLVIIFVSWVQTVTPPEASELSEPRLSEGSPKLQQCASHLTEESQPLLLGEVEEGLEGEAVGLEATSGYNTADKEGSEPPFSQPGPVSPDAVSAPARTVVHPALTHYYIIDTQKNERIFPNDMQAMGRLDTEYFLGNMMILIRTPDADDPSATSGKPENWTTSAYLRGKQRRFEFQFQVQLKKIPTGRVYFATELQEPVKMGMIQRAFVSAAMAFVKTTNKSFHYSITGSSPSSDGKYEKPHMSFPVEEGMNRVVATPKGQLPPQLGTVIEEDDASVARRKKGARMDWKLDEIYTFALWSQYVDFLEWRVLNLPGIRPFNLTSVIGTEAIRLVLYEIPDKADKHYRKDMQTIITIEMSNAERSGMGPAARKWTKTKTTNQNLVDTEPEQVPGTSENVDTGDHLASRDSFGGEVDGDVDLPSGVLIDEADEEAVAELGGGIYVRSGDQISLRESNVDSNLSENLSSCFVTAGGGFAVLQEQSSETIVIEKVTKSRRSAGSQLIHSGDVVRFKLEAKGKKNNEIEFKYLSVHRGWWLKWVSTPPSKNGHFTLLTHETEYSVNGEEQVRSAETQSSYLTLGGSFWLQHKRWSKFMVGVSAESSATYGGRMLGLYSRKDSVGGPSEDPYLSDEGEVQELDQLVCNYEKGKSNWMRPLQLRAYESYSCTVPTGTVTVKTESDDQSVEELADNEKVDLVFSSDDFQMDAPAWLEIMNRRERIRQLTYAVRVLPAEETLSDAGTSDDEFQTEDVGPPPVLGAFIRLRTGAELAQIMRVGLNWRHSQSITRRKTIPQSSSMLSVSPSPGTPNSPKRKSASIPLSPDSIEETSMPYQFEEEDSEYEWDGDAETTDDVEMLNVAYEGEDTTDRRPRKGRKLIGKIAKSVKRHSTTTGKSVVRRSLKVGKGTVSAGKAIIAPSVKVGKGTVSAGKAIIAPIRHKNPPEREPKAKVPGDRKMRKRRERDLHAAISRSMRRIEKAESKLTAVESPTFVAGELCAPEQSCRTVSKMLSMMSNLPRTSQFSDSFSELLATQVVEATEQDGWFLQGGALQLGVVPQEDKGKGQLVAEGVVARCLWESHWREEWYGMYESCVQFYAPLSKVPCLELSFQDIQSIRRLGSGARSPLPGFPMLVIETAWLCHYAVFSDETALDNFSAKARLLLENYSPTDGLDPNLDDNVLSKARFWQGFQSSVESSLSFGKGKWAEIFVGKQAKRRTILNGRRMKFDLDAMDISTNEFVQGLLSASLSFSLDSLTEDPGALIRFLDATSYLRTLTLQDLNLKSASTFCVFANLYHCLLQHTLLLSVNGPLKRSSYEHIMRTSCYEIGGDVFSLAEIQSCIIRGQLSRPVVPKAPYVETSKQSRSYRYYALGYTTPRVNFVLNSGHAFSPKEVPILDPETLESQLNTVTAEFIRRNIRVDSSKKTIVLPKVCDVYRNDFGTDFNGMNHAALIYCMSYLDESMVKTIRSFVRDEPIIKYQFAIDQYHSVLEAKDAYPVYNQDDQGETETRSDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Z5</accession>
    <name>B7G9Z5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183978.1">
        <property type="nucleotide sequence ID" value="XM_002183942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Z5"/>
    <dbReference type="PaxDb" id="2850-Phatr49248"/>
    <dbReference type="GeneID" id="7195543"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49248"/>
    <dbReference type="eggNOG" id="ENOG502SF8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_904519_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Z5"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853118" description="CRAL-TRIO domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="134"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="310" mass="34027" checksum="BB7F133CDFD2AF30" modified="2009-02-10" version="1">MQMNIPTTLLLSLIVFWQSLQSAFGFSLVAPDKSVTQLLQDHAGDIANLKAAAQQQLNRDDAMAEEPYCQDVFYLRYCLELKDSPSQLDLLKRNLAWREGPGRLICQKAVQAVKEATAGEGWNNEPVLAKAPFSETISMYIKPSNVLTTTSSQADLVYCIRAGSIDDNGLMKAVSVQQMTEFFLYAKEVNAIVANQRSAYLDKLLCVLTANDLSGVKLIGGSADFRKALSSSSKTATELYPATSGPTLLLNLPILLNALVKLFTPLFPPAVNARLKFAQGPLKDLNSLEEITPQGSGRVQFLRQMDDIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA78</accession>
    <name>B7GA78_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_15797</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184022.1">
        <property type="nucleotide sequence ID" value="XM_002183986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA78"/>
    <dbReference type="STRING" id="556484.B7GA78"/>
    <dbReference type="PaxDb" id="2850-Phatr15797"/>
    <dbReference type="GeneID" id="7195592"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15797"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GA78"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="303" mass="33112" checksum="C9226C851E5A5BAF" modified="2009-02-10" version="1" fragment="single">VAGAAAGAFSKTAMAPVERVKLLLQLRHSVYPPPVATAPLATTTTTPLASPSAWHVAREVYQTQGFRSFWRGNLPSVWRTAGTAAVNFTCMDYYKRVAVQPLLARTILHRTTTHAPTFWSSLISGGLAGGTATTLMYPFEFLRTRLAMDLGKNESRQYQGALDVLRRIVRSDGVGGLFQGYGIALAGGIFYRVLFLGGYDALKNELKHRKRAAMVVGNTGTVPAISLSAGTLSYPFDSVRRRMMMQAGQAMETRRYRSSWHCITVVLRTEGIRGFFLGLGPNVIRSVGGAVLLVAYDSFRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB33</accession>
    <name>B7GB33_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184391.1">
        <property type="nucleotide sequence ID" value="XM_002184355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB33"/>
    <dbReference type="STRING" id="556484.B7GB33"/>
    <dbReference type="PaxDb" id="2850-Phatr49575"/>
    <dbReference type="GeneID" id="7198239"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49575"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_1"/>
    <dbReference type="InParanoid" id="B7GB33"/>
    <dbReference type="OMA" id="TMYLAQY"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855657" description="Ketoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="375" mass="40930" checksum="DAB6C8D415D02551" modified="2009-02-10" version="1">MLPLSLWNKVFTATAAAAASSVGWWMLDCPPSLYIYDKFRTLSSRPGREGSFHDKNVWIVGASSGIGRELCFQLAASGCTNVIVSSRSTDKLERVASETIRRYPRTTCHVLPLDVCDDTQLQQCVQILPCPVDLVILNAGSGHLSPALETSPRTVRNMLEQNVVWPMILIPLLLHSDFGVFRTSSSQIFPRIAVTSSVGAVLPLPLSSAYAASKAALNRYLGSLRAERPDIRIDIWCPGPVDTDFHGSQSAANVATLTKGTLADESVSSASVSRSRLKMPVARCVSLMLSSLLQTSRREVWIVPQPTLTVLYLQGLFPGLVDWMLSLIGPKRVALWRAGLDLYDPASWTGRRPTASLGTSSQNKNENNESDSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBU0</accession>
    <name>B7GBU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184585.1">
        <property type="nucleotide sequence ID" value="XM_002184549.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBU0"/>
    <dbReference type="PaxDb" id="2850-Phatr49765"/>
    <dbReference type="GeneID" id="7198348"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49765"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262953_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBU0"/>
    <dbReference type="OrthoDB" id="49219at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47764:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47764">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="862"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1283" mass="144936" checksum="C301007DABA81798" modified="2009-02-10" version="1">MSESRSFPNGKRRHSMYGRHQRPKSAYGQRSTNTGDSAPPQEGPCSPTSNANDHSNGKVPSMRDDRGISFLQDMAGPSKTGHPVVTMPNCTVVESAQLPVVNKLHSRKRSRREGNVEPLQQARSQQQATGSRRLVSNFPQPGMAAVGNSRDGIEWADRQSGLVSEEKVRRTAQSNQPIPRKKKTHSDYTKKSIQEQHRPHRGSRLDVRFIVPKLKPRHNCPKARVESICDGDSDNTADEGISAVQTCETLPKSIDVHTSAKRQPSRTKTQLTSSCPSADSVTSSGLEANAVELPLLSCKGTPVPGKRSSSKLWTSLERPSQSSKTDDAGTKESPVDLATAAIKQQHSEAEKNENEHKPSKKLLWREMSDDDDDYTTSRNRQARHSLAVVNTILQSGLESDVVPTKPTNHSAVNFDAGSDQDQPSSSFLSRIVDRGRKGIARTKLGFLNTLQSQKKEKKLSLSKQLNPDAQSKTLQHRGVSSDCKRKPIKGKKITIGNSFSHKGQESSLLDQTPERDRKDPFFECKGVGLTSFSEHTTPFKTKLNFCKSQPRSSERLLLKKKTKEPEVVEILDDSESEMTKSPPMATRSVKRTLNCAVIRIAIGTKVFCSGCQIRLRATCKLMLEFEPHKKTTRKGTESLNKATLELDLQHDLTECKYYLNEEFSAETNEGEEDAVGSFLAIKVVPNNQNGLKIYSNSYQPDKENTKRMFILIEFRENKDLRDLVETIQTSRPPAMDLFFNDHSKLDSASAEIYCQPLIDDCKREARHRQKSMHSLSVHRKNSFLAGRKEDDLLLIYPFDADEKIFDQAAVHLTEAKYDSRCDSNLQVCALSESSIPSPEQKSADCDGGNADMNNMNNRSHLAIIRVTDYERLVIEDEYLNDTLIDFWMLWISRFDDLSKFHVFSSHFYTSLFEDGSIAVTKWTERKGIDVFDKKFIFVPINKSLHWSLCVVVNPGQILQHPDLRGKDEHLDESSPMPCILFLDSLKAHQKTQVAHRIRQWLNSEWQRLHKSSSIPNPFQSKTMPVIDPKIPYQNNSWDCGVFVCRYAFALYKLRNISFSFQEYRQDCFRSLITNSEPFQFDMKDITRLRQEMKTLVENLCTAYVPWKSEQDRKAKEDRRKAKAVAEETVQVDNNVPEDPDSSEGNEVVVNNEDKVDTANARWSAVVKGIEANENNIIQDSLLIVDDLNDDDNSRMHETSQSGSKEMVFGPDWTETYDPMEVDEDEAHSYATQEGLTVERVSPAEGSIVKDVEMKDDLHTYKAQDLVDPLDTEAVDDDVDIDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC27</accession>
    <name>B7GC27_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184731.1">
        <property type="nucleotide sequence ID" value="XM_002184695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC27"/>
    <dbReference type="PaxDb" id="2850-Phatr49850"/>
    <dbReference type="GeneID" id="7198672"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49850"/>
    <dbReference type="HOGENOM" id="CLU_1430603_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC27"/>
    <dbReference type="OrthoDB" id="48987at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20842" checksum="3D3816FEB33BEF3D" modified="2009-02-10" version="1">MIRRQRSVSMKLIITVAHSLSLVLVTCLLARSVAFTAPSRPVSVPRTVEHARFGAVPVSSVMARHRSARHPMFMTEDAPEAQREETIPATSPQAVRQKVAAEKEKSGLAKAVLLAVPLFCKFVIVLCIKFLTDLVVFPLLWTYRLARLTKKKILGLFGKRSSPFDGANGDVQGNKDAPNQALPPKMSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC59</accession>
    <name>B7GC59_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184745.1">
        <property type="nucleotide sequence ID" value="XM_002184709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC59"/>
    <dbReference type="PaxDb" id="2850-Phatr40694"/>
    <dbReference type="GeneID" id="7198508"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40694"/>
    <dbReference type="HOGENOM" id="CLU_1535458_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC59"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="175" mass="19405" checksum="54F37ACD0F058781" modified="2009-02-10" version="1">MKLTEESILNMAVSTPRSGSTPIHPSGSCEDQNCATPERKLSAGLWNSRPHSHQSSSASDAESSELVYFANRGRSPLMPMLPDSPPNLPKLALPFRLRPTSQRVAAHLHTRRPRILPERNTIAFIPIEDYSEEDDSWPGAPRVDGCPDRRVGLLAPRPRLRSLPTLRDAKRAKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC60</accession>
    <name>B7GC60_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184662.1">
        <property type="nucleotide sequence ID" value="XM_002184626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC60"/>
    <dbReference type="ESTHER" id="phatc-b7gc60">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr40695"/>
    <dbReference type="GeneID" id="7198592"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40695"/>
    <dbReference type="eggNOG" id="ENOG502S059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081870_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC60"/>
    <dbReference type="OMA" id="LIHPIGV"/>
    <dbReference type="OrthoDB" id="199322at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="285" mass="32101" checksum="54638D360D8785CD" modified="2009-02-10" version="1">MVEDTCESLVAFYSSFYRRERSGIGMSSWFWKRFLSTWQGPAVYAVDLIGCGVSHGADAWNPEEKGMSFPLGWVKGCEALMEQVILRSHTKPFSLGKRYPTCTIMVQGGLAPVGVSLAFRNSQTVDRLILASPPSWKDMTTAVPERELARNYNFLKSPRWGNLAFRFLETREAVEFFSNAFLFEKGCDAEWLNECVTEMGVAVRPPVQVFNAGFCMHRSYAEELESLSQPVLILQGRDDKARLSERALYETSIPTCRIETLPGKNVLPWESPDAVGLVVREFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCR0</accession>
    <name>B7GCR0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_50045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184843.1">
        <property type="nucleotide sequence ID" value="XM_002184807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCR0"/>
    <dbReference type="SMR" id="B7GCR0"/>
    <dbReference type="PaxDb" id="2850-Phatr50045"/>
    <dbReference type="GeneID" id="7198740"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50045"/>
    <dbReference type="eggNOG" id="ENOG502R87K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GCR0"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="696" mass="77016" checksum="16E364D0AE9EF09A" modified="2009-02-10" version="1">MNEDSTEDPDDGSVALCASCDRCRSRKTKCDGQRPCGNCLAKYMKKNKLSSADGIDFTECECVYSPAKRRGPIPGRTAGQARKATELQHHQQQQPNDWPQNYHNNPSTGVNLNGTGLDAQMTAALFSGQTEQASLQQKLNFLQSLQNQDEDHLMMQQQQQQHQMDEPANRRVKREDAGQNTSTNGIPRTITTHTHLLERSNPDGARLRAYYQLSIDELYRLPPIPTDEEYCARLNVPGMTPQMIPGPHLAALSAARFAEIALGALVHNEVSLAMELCNAVVHCLRESVQEPVQTPVMFEVAKAYFLLGVFRACRGDMERYFKYRRVCMTYLAKLENDDKTAVLLAAVAYLDSWAPYATQTELKYDVKLDAGAIASDPKNQNWIQGAPPVYLNNEAPLHARALDALACAVRTCCDQANSRFALISKEANIEGLDTIPSESISSATYNAVLSHENELCSRNIVLSAYTLMQQHESTDSSRHKNEGQHMVISAMDAFLENSDEDGNGGFTDSQIQSLLSVCNTAIENPFLLHHAGPTYHMVSNAAVLLCHLLNGLHMAKMNGQDFGRMEQSMFEEVFDAFISIRKLLTIHRRKLPVKLRCHAIPRPSMDGLKEGQPLIDLGETILCACRGCQGFVLMACSPCVAAERAQAAQHDLSVEAAKEAEAIEMGELDNELDNLGAEFDMDDDMLLGMISNLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDH3</accession>
    <name>B7GDH3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl14</name>
        <name evidence="5" type="ORF">PHATRDRAFT_50259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185212.1">
        <property type="nucleotide sequence ID" value="XM_002185176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDH3"/>
    <dbReference type="FunCoup" id="B7GDH3">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDH3"/>
    <dbReference type="PaxDb" id="2850-Phatr50259"/>
    <dbReference type="GeneID" id="7199107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50259"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="InParanoid" id="B7GDH3"/>
    <dbReference type="OMA" id="MIQMQTR"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15166" checksum="DCAF978A2A0B701E" modified="2009-02-10" version="1">MGEKGQRGRALASGIKHRVSAGLPVAAVVNCADNSGAKNLRIIAVCNIGGRLNRYPKASSGDMVMCAVKKGKPELRKKVMPAVIVRQRKAFRRKEGVFIHFEDSAGVIVNNKGEMKGSAVSGPVAKECAELWPRIAANAGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDQ4</accession>
    <name>B7GDQ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185254.1">
        <property type="nucleotide sequence ID" value="XM_002185218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDQ4"/>
    <dbReference type="FunCoup" id="B7GDQ4">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDQ4"/>
    <dbReference type="MEROPS" id="C85.003"/>
    <dbReference type="PaxDb" id="2850-Phatr41252"/>
    <dbReference type="GeneID" id="7199066"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41252"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_895638_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDQ4"/>
    <dbReference type="OMA" id="CMNIDLE"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22771">
        <property type="entry name" value="OTU_plant_OTU7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103642">
        <property type="entry name" value="Sec-C motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="311" mass="34654" checksum="466A56DDBF894713" modified="2009-02-10" version="1">MGKKKSAKKGSKGYNRVPDDGGEHVSRSPSMSCSRKKRRGKNNKASGNFAEDSKLRDSLESDGSKTIIDIDADGNCLFRSLSDQLYHDFGSKHAEIRSDVCDYLEAFEEDFSVFLVLDENEDDEDAADFNTYIKNMRQDGDWGGNVELVAAARLYRRNITVFSASMGAYTIEHGSDKQSAGSDLCISYHDNDHYNSVRNHASGKPSVPLKTFVKSESDDNEFCTERKEAMVDGPCEESTLDALPDTGMSIETTKKSAPCPCGSGLRYKKCCFASKSHVKRLHRMQDSEKRDANVESEHQPKMDGTFRVMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDV8</accession>
    <name>B7GDV8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_16827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185323.1">
        <property type="nucleotide sequence ID" value="XM_002185287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDV8"/>
    <dbReference type="PaxDb" id="2850-Phatr16827"/>
    <dbReference type="GeneID" id="7199185"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16827"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341146_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDV8"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF121">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="110"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="475" mass="52487" checksum="A5F78121F6B6A9A1" modified="2009-02-10" version="1" fragment="single">MDRNITNAIDEEGLPLIYDKDLIEAYWTKERGALNKRWAYFVGKAVPFLTKLTTLFIRDGKIAESEIPALSRQARMDLQDLGPTFIKAGQMMSVRPDVLPQATLDELTTLQDSVVPFDTVTAVAQIERELGGPLGSFFTSISEEPVAAASLAQVYLATLADGSNTRVAIKVQRPDVLSTVSKDLYVLRRAAEVFQGLIERFAPQQKTNYVALLNEWAIGFYTELDFQNEAANQRRLRDMLIEKNITDVTVPLVYDELCTRRLLVSEWMDGRKLSDTSPEQIAEVTPAAQEAFLTQLFDVGFFHADPHPGNLLLLDEPTKGGAKLALIDCGLMASIDPVDRDNMISAVIHLANKDYAALVDDFIKLQILPADSNRAAIVPLMDKALSPYVKGGGAKNQVGGFQAMTQDALTVLNDIPFSVPPYFAILGRAIVTLEGVALTGNSDYGIIMESYPFIARKLLREGRPEIQKALQEVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE42</accession>
    <name>B7GE42_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185422.1">
        <property type="nucleotide sequence ID" value="XM_002185386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE42"/>
    <dbReference type="PaxDb" id="2850-Phatr50435"/>
    <dbReference type="GeneID" id="7199250"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50435"/>
    <dbReference type="HOGENOM" id="CLU_507619_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE42"/>
    <dbReference type="OrthoDB" id="41246at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="527" mass="58210" checksum="DDCB8D0709260D3B" modified="2009-02-10" version="1">MATSTNREHWSHPPAVHPARPPVYDSPGWSHGGGGGEPYESYAGGPAAYRGSSAATYGAPSRRAAYPHVPVRPPRPHDFAPPLSRSGWRPPVATERHVRANTNPPHKSPPKAGDTGCATSASTNRVSSRTKKKDADPLALLAKVSSTMEDDEDEEEVKEASPTSPLQRRSQEVPVATATPKSDPSTYVPRQPAYTYGPKPITPTGNYSPYDDAPQYHHHRGPAYPPPQTRGSLPPHPYPPPSYLPHARVGPTEWDTGRPVMVERTSFDSHDSGDYSRGAPPRYYYDGPDYGPSSPPQHYYARSGSYPPSYGGPPPQWGYEGPPSHAPFYPPRGPPTAHGGLYERPGPERDAPPPPYQSSTAAPYTYVQQPTLEEKTVLRKKFSWKHYPELERFLISHRDEYLEHSSKNYTAEQKTYNNWLTNQLLHLAAQHNYQFDPQAFTFVAIRDRIRCYYKSYVQTARKRGLPLPTTPSIKKTKSPRDGDEEVSLSTPPVESKGVTSSGNNEGETGRAANDAMTTDPREDSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7GED1</accession>
    <name>B7GED1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_3686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185414.1">
        <property type="nucleotide sequence ID" value="XM_002185378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GED1"/>
    <dbReference type="STRING" id="556484.B7GED1"/>
    <dbReference type="PaxDb" id="2850-Phatr3686"/>
    <dbReference type="GeneID" id="7199295"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3686"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521263_0_0_1"/>
    <dbReference type="InParanoid" id="B7GED1"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="184" mass="20454" checksum="ADF95761ABF7DEF3" modified="2009-02-10" version="1" fragment="single">SSGVLLYGPPGCGKTLLVKALASTARIPCLVVTPSVLLRKYYGETNAQVRSLFSLAAKLSPCILCIDELDGLFRERSEQEHEVSRDLKTEFLQWVDGMMSKDDEDRQILLVGATNRPFDCDSAVLRRMSQSHFVGLPDLTARSVYLKHALRSVPITNDFDFNEIACRSEGYSPSDLRQLLQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEE3</accession>
    <name>B7GEE3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185472.1">
        <property type="nucleotide sequence ID" value="XM_002185436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEE3"/>
    <dbReference type="PaxDb" id="2850-Phatr50531"/>
    <dbReference type="GeneID" id="7199337"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50531"/>
    <dbReference type="eggNOG" id="ENOG502SE5M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726610_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEE3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="40425" checksum="6675232D921D58DE" modified="2009-02-10" version="1">MTHCIDTAGVEEAALQMDETTLGSTEHGDKESPATLNCNLESSDYLKDIVFEYEDEVHPRQPDTLPAVTGEGEEERDSEDDTVVVRWQLLHKLQTILVIVAATVATFGLHNYLSVFNSIAASGLVGLVSGLVLPQYMALAAFCGSFAGMATLQVIPSVVAAISLGFFCALVVLVFDYKGFLLGIGGRLGFIALCACTMHFVLSIIVVAPSPEASLVDISSFPSIEEFFPIKLFRVLSTTIVGSIFMKLWRLTFARLEGSLAKCMAHSVVASSATGILVAWTLPLWATGPVYCGSFVAMAAPEELPTMMSIVSAATLAGLAQLALDGFFLGGWGGKLGTAALIGVLLYRIPVRLLAECVDSQEDGSESDAGNKPNVPGMTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEF8</accession>
    <name>B7GEF8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185514.1">
        <property type="nucleotide sequence ID" value="XM_002185478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEF8"/>
    <dbReference type="PaxDb" id="2850-Phatr50544"/>
    <dbReference type="GeneID" id="7199378"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50544"/>
    <dbReference type="eggNOG" id="ENOG502SCJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892718_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEF8"/>
    <dbReference type="OMA" id="FYEKHDP"/>
    <dbReference type="OrthoDB" id="164285at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35385" checksum="162D054C2D43AB86" modified="2009-02-10" version="1">MARGAQAKLRRRNRKGDDEEAVIDMFGPKQGGAEATGTSDFDEIPMPPGLASGTTSESPVEADNSEEESNLPKKKKKKSKPTAKEPLAGTASSAGSTNGIKRTPLILLILMTGTTLLPAFIYAGDYLSTFMAKNHIMGQIGFRMGVGAVPRKRVVSFYEKHSPEKLEEVPNILSKHYGDYPKLIRKLERKYQDYGYFLGWEEDEAPMRLALDQVHAMYETWVTDYWNRYAPQPLKTAARNMRYNFSFLYKKLRKAWKKQVWPHLEPFLGVPDKRAAEKQKRKDAADARKRRAGSSAGTRRKNTDYRDDVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GER8</accession>
    <name>B7GER8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000635">
        <property type="protein sequence ID" value="EEC42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185596.1">
        <property type="nucleotide sequence ID" value="XM_002185560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GER8"/>
    <dbReference type="STRING" id="556484.B7GER8"/>
    <dbReference type="PaxDb" id="2850-Phatr50632"/>
    <dbReference type="GeneID" id="7199463"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50632"/>
    <dbReference type="eggNOG" id="ENOG502SWNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437131_0_0_1"/>
    <dbReference type="InParanoid" id="B7GER8"/>
    <dbReference type="OrthoDB" id="204102at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="2">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="622" mass="68645" checksum="DE54FB6EFA5EEF38" modified="2009-02-10" version="1">MTPSASSKKGKTKLEEFFEVAERRKSLTSMDLWLKMTSSQSQLSTLNQRRTHNGSSKPKSSSFALKGNGRMPREYESETSLKNGLAVRKESHPPTCPKVHTSTSMGGIEGINNRPPMLLGAGHSFTRTVEGASAGISGVASDDDDSIEILKVVPSVIDSIGAAFPSEAPVTEEDEERWLQHAIRKSYEETRKVLPSKHFPPLTPRTSPRILARKRARASEKYLEPDTEGKATSSKFLKFSPAKSVFQSTSPAASNDDDSSKDKATTSKVPPGDHLYTFNEFDRMFDDVFLDFGMEVTDVEEGCLVRTGNSKVSPSDTKGQSKAQYGRLLPTATQYLLADALCVTKKDTFVDIGHGIGNAVIQAAYTMGCESRGIEVMAGRNLVAELIMENLEGQRKVHHERDNRSVIVGKILLRHGRLEVPEHRTFLTNPEGVTKAFLDNFNGVFADRSAKLRQRYTLDQYNAGLFALMKPGSMLVALHKLDLGPTYLEANTYRKRHNLANQDNILASFYALEEFSFGPACNAVTWSQGGGCTDAIIGYKYTRLNQKTPEGKAVFLCCNRDCDIARAGTPIDATRLVESDEGDGTRVVINTCICKYTPIAPRSGRNRRPRKFRESLSEESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Q7</accession>
    <name>B7S3Q7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_bd375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5"/>
    <dbReference type="EMBL" id="DS999263">
        <property type="protein sequence ID" value="EEC42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176197.1">
        <property type="nucleotide sequence ID" value="XM_002176161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Q7"/>
    <dbReference type="STRING" id="556484.B7S3Q7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft375"/>
    <dbReference type="GeneID" id="7205070"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd375"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3Q7"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="107" mass="11922" checksum="FAD6AE216E8CA0F1" modified="2009-02-10" version="1" fragment="single">SDDNKPMLFVFHGGSGSDVKDIQYAIEAGVVKMNIDTDTQWAFWDGVREYEATNREYLQGQIGNPDGADKPNKKYYDPRMSLRAGEEAMAARLCQAAEDLKCNGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7S401</accession>
    <name>B7S401_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_bd1645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176312.1">
        <property type="nucleotide sequence ID" value="XM_002176276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S401"/>
    <dbReference type="PeroxiBase" id="2540">
        <property type="entry name" value="PtrAPx-CcP01"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatrdraft1645"/>
    <dbReference type="GeneID" id="7204866"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1645"/>
    <dbReference type="eggNOG" id="ENOG502SQ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534709_0_0_1"/>
    <dbReference type="InParanoid" id="B7S401"/>
    <dbReference type="OrthoDB" id="10655949at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00314">
        <property type="entry name" value="plant_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002863530" evidence="4">
        <location>
            <begin position="33"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="5">
        <location>
            <begin position="160"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="520" mass="56894" checksum="CD82A946FD70371E" modified="2009-02-10" version="1">MDLTIIDEFRMMILPSVHFVFALLWVAVPLSAQPLSAQDPVLSPSKGTDVLLPSEEAAWWATLSIQEKGKLSQLFHAPWFVTLQEKEKIAYCYVAQKVYDLLNSGADSNPDDSYRGFAPLLLRTSFHSSGSYHHGSGSGGSNGGTIFNQAELDDDMNGCIQTATDEINSRLNNSAIVSLADAVIIAGVVALDSMGFPRMDLIRVQGGRVDLEKLAYTQSMASPDNDPMMHFVTMYNLTVSELVAVIGGGHNFGSAHGMCSGYQGQWTTDPLSWSDPETGVPEFFVDLLKDDWLWRKVCTYKNGTVSYMSMEDPFSSDIPAVVEDTTPPSTCKTELSEDPLNCEAQAMRGCNFADGVYNTSDSPCDVKLLKMRLRSDFFLKANPMTRPHAEAFATDPDLLAQEFGVAYRKLTHNGLDRCGLSGRGCDGNTKCITYTDTVTDRYLSSSCVSDVGYNYAADEDSDYGSWSLDHGASIAVLFLLAITSILSIFLTFKAVRKYAKAPPDVGKEYTEPSSGDREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3S2</accession>
    <name>B5Y3S2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_13402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185888.1">
        <property type="nucleotide sequence ID" value="XM_002185852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3S2"/>
    <dbReference type="FunCoup" id="B5Y3S2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3S2"/>
    <dbReference type="PaxDb" id="2850-Phatr13402"/>
    <dbReference type="GeneID" id="7204659"/>
    <dbReference type="KEGG" id="pti:PHATR_13402"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1177370_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3S2"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="117" mass="13566" checksum="ACB069911FC39ECD" modified="2008-11-25" version="1" fragment="single">PHVRSAAGKTWIDSSLDDWPQNDFRIFVGNMGNDVTDQQLYDHFVSKYPSLLRTKVVRDAKTSESKGYGFVSLGDALECAKAIREMDQTWLGSRPIRLKRSNWKDREASKRIYKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3Y0</accession>
    <name>B5Y3Y0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_21135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185913.1">
        <property type="nucleotide sequence ID" value="XM_002185877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3Y0"/>
    <dbReference type="STRING" id="556484.B5Y3Y0"/>
    <dbReference type="PaxDb" id="2850-Phatr21135"/>
    <dbReference type="GeneID" id="7204692"/>
    <dbReference type="KEGG" id="pti:PHATR_21135"/>
    <dbReference type="eggNOG" id="ENOG502RS9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_1"/>
    <dbReference type="InParanoid" id="B5Y3Y0"/>
    <dbReference type="OrthoDB" id="276825at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003964">
        <property type="entry name" value="PRK05456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF7">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="18848" checksum="84E02F817F877F2A" modified="2008-11-25" version="1">MMGDGMVSQGSIQVKPNAVKIRRIPHKGDDKEHQGTIVGFAGSTADAFTLLERLEMKLDEYPGQLARSCVELAKGWRTDKYLRRLEASLIVADATVSLELTGNGDVIESHDGILGVGSGSPFAIAAARALMDSSDLDAEAVARKAMNIAADMCIYTNKEFLVETMETKEKEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y400</accession>
    <name>B5Y400_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_46855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185752.1">
        <property type="nucleotide sequence ID" value="XM_002185716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y400"/>
    <dbReference type="FunCoup" id="B5Y400">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y400"/>
    <dbReference type="PaxDb" id="2850-Phatr46855"/>
    <dbReference type="GeneID" id="7204711"/>
    <dbReference type="KEGG" id="pti:PHATR_46855"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="B5Y400"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="245" mass="26912" checksum="EEBB10F69BB21923" modified="2008-11-25" version="1">MITEVPKISRGAFVVLEGVDRCGKTTQSGLLLKRLLAAGIAACSMRFPDRTTATGKIIDQYLQSSQNLDDRAIHLLFSANRWESADALTAHLQAGTTVLCDRYAYSGVAFSASKIDKKGNSLLSLDWCQAPDQGLPAPDCVIFLDLSQAEAEQRGGYGGERYEKKEMQIRVRHRFGDLEAIDKASGRVAWKFIDAAQSVEQVENDIWKAVEETIQAVKGSKALGKMWQDGEYEFKSVGDGESESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4A6</accession>
    <name>B5Y4A6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185805.1">
        <property type="nucleotide sequence ID" value="XM_002185769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4A6"/>
    <dbReference type="PaxDb" id="2850-Phatr46947"/>
    <dbReference type="GeneID" id="7204764"/>
    <dbReference type="KEGG" id="pti:PHATR_46947"/>
    <dbReference type="HOGENOM" id="CLU_044543_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4A6"/>
    <dbReference type="OrthoDB" id="40253at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52444" checksum="2A98217D6A5AC60E" modified="2008-11-25" version="1">MRKTTIYIAERYHLANPSRFAVCSRLRLVTTIVTLFVYLLSRRTLLVYDVWATFSTTHEAELFLPAMAPATSRNPDSEKRNQSQIEILLDSSNLTVQEMSIDINANGKLIKFAPSSSKQFGVPPQDAFSACLLVMDENFRLSEWIAYHFFTLPLRTLVVLVDPRSRTSPKLILDQWREYMDIVEWTDGDILFNYNSSLLKGTTREKTKLHRTRQKLFYGSCTRYLKATNRSWTTYFDVDEYLAINEADTFDSSERIGQSGSIIRLLRETKAKPRERLYHGPCITLPRRYFSGSKESTVDMVFNRVPDFLNASRFETLRWRYRSDNTVTENGASKAIMDVSQIAWKELRRQRLEVHRPIKSCPPNHVRSGPFSIHHYLGTWEAYSHRNDARDGHHRNRTQWELRSDQTSGGSTDQIRPWIAGFVQQVGKQRAAYLLEDVGIYQDRVSDDGNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Z7</accession>
    <name>B5Y4Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_18579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186383.1">
        <property type="nucleotide sequence ID" value="XM_002186347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Z7"/>
    <dbReference type="SMR" id="B5Y4Z7"/>
    <dbReference type="FunCoup" id="B5Y4Z7">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y4Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr18579"/>
    <dbReference type="GeneID" id="7204395"/>
    <dbReference type="KEGG" id="pti:PHATR_18579"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Z7"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="301"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="510" mass="56254" checksum="1D1ED0C19240797C" modified="2008-11-25" version="1">MADAKSLFTLLESAAGYALFEVVAFEEIGGLLEDSMDTVTDLQRFSRAVKLKAFSPFESAAEALENANAVSEHAMTGTLHNFLEMNLPKVKKSSKTASYALGVMDPALATAISEGLGVSCRSDDTIREIARGCRAHLDTFVKGLEGGAAEKAQLGLGHSYSRSKIKFNPARSDNMIIQSIALLDQLDKDVNTFAMRIREWYSWHFPELKDIVKDNIMFARAAAFIQDKNSLFTNSASDSGEKIVGDEDLAKQVIASARTSMGMDCSPVDMINIVNFTTRMVKLAEFRKQLGMYLTEKMSIVAPNLSALIGDTVAARLISKAGSLTNLAKAPASTVQILGAEKALFRALKTKGNTPKYGLIYHSTFIGRADAKNKGRISRYLANKCSIATRIDSFSDEPSRLYGEKLRDQVEERLKFYETGQAPRRNLDVMEEVSRELRAAKGEEDDNVEMEDISKKDKKKKAKKEKKSRKSSDAIEVDEELKRSAKKAKKEAASSEKKKKKKKSKSGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y543</accession>
    <name>B5Y543_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_44026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186405.1">
        <property type="nucleotide sequence ID" value="XM_002186369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y543"/>
    <dbReference type="STRING" id="556484.B5Y543"/>
    <dbReference type="PaxDb" id="2850-Phatr44026"/>
    <dbReference type="GeneID" id="7203990"/>
    <dbReference type="KEGG" id="pti:PHATR_44026"/>
    <dbReference type="eggNOG" id="ENOG502S5VN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720551_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y543"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841274" description="Fe2OG dioxygenase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="279"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="384" mass="42355" checksum="4EB206DC579FED7F" modified="2008-11-25" version="1">MGKLLYLRSGLVFAASALLGVTPADGFSPTATRSQLLAELQRCLTPTDLLDRVGARVSRSIDPDGSLASLVLVRLSKLVISLDNQDRAFVADESSTKTLNAIIESLLDSDPSSNCESIVEATKACSTFSRISPYSPNSTYERLFNFWNDSSDIVSQLEPHHTSGVKWAFDVLTLQSSAPSPTALDQAYADLNLPFAIIPGCLAGLESLSVDRLTSQVHFRVDDIRTTSNKVVSERRQTAWEGDTGVAPFTYSGKAMPRSDWSPLVVQVRDVVQARTNQYYNGCLLNLYTDGCSGMRYHIDPDQGTLWDYDTAVVSVGASRRFAFRAMSSSTLQPHNFVVMHGDLTYMFGECQSQFQHTVKKADDKTDTTPRASLVFKRTWECKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5G1</accession>
    <name>B5Y5G1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_44133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186179.1">
        <property type="nucleotide sequence ID" value="XM_002186143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5G1"/>
    <dbReference type="PaxDb" id="2850-Phatr44133"/>
    <dbReference type="GeneID" id="7203886"/>
    <dbReference type="KEGG" id="pti:PHATR_44133"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297629_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5G1"/>
    <dbReference type="OrthoDB" id="46083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="846"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111643" checksum="31F1682104CAD507" modified="2008-11-25" version="1">MTTIHIIDSWADLLGGITLSDCRNVTDPSCVGGVANVAAFARHLTRSGASVTDSPSGGTAEDIEEPYIVTPRLDRYSPFVQMHPLGWSVNRLIFVEVLQWKFFISSPALLYLSSTARGSTNGSSTISTNSSLMSDLQTDELPFLLTNVAVPPENDWYPYTKAIYFDETTHLAFLSVADSDEPLNAPQIESATGALNYIARLNKESDCDAFVDDGGGTAVALGSSWDNRTCWIPVVAFGDSENRWNNFLLAMTALENPPSLIMDIEGHDARFFTPQKYNQTWVSSYKMNSTTYRQQSIVLAEDSRTIVSVTATAIPLNELPDEFKDNIYTSHVTRMYELGQEAANKDPIVGTSTFMPIARIDQYRRCMGGECEIGNLFTDALRWYSSADVAFVSSGGLRGQGWPEGVVQMSNLWESLPFPNTLCSGTMTGVSLFKLFNYSTSVANFEVKETVSGGQLLQVSGARLRYNTKLPQGASRMVRLEIWDKNANQYAPVQRLQLYKFATDNFLCETNIPYPELLGQNFYIDGEVPGVVRDDLHQNIVADYLTQLNTTYQATIEGRLINDTTVLDAMNLVQIEGGCGQGTYWVFTQQSCKVCPNTDQVYFGKKELEFASESGSSKPVEGRFEILNNAGFPVSVGPRSFPFWVTLTVFLCNGTIPIDPIPAGVTRVLQSGEKLTVGLSISSEQLEAGTAVATGSFSVVDGGSFPGCIGNEISFDILVRVDPSRELNQIGGIRWVGWSLFMVLVFSAMFFYTWVCQHERIAVVRAMHRLFLNTVCLGIVVLGSVLIPVGFDDGAFSENICNSACASIPWISAAGLSTIFAAMYRKLGSIVGKNEDAREFRGRRVVLTFAVFFGLNASILVPWSILAPLHWDRTPLVQEEWKSYGRCSTSDTSSLAFVVMAGVLNVSGFVLICRLAYKAQQIQDRRDQFDQAKSISLALYSWIQLAVVGIPVLSLISAETTRARYFMIVALIFALCISMLLSLFIPMQMQKTMQSVRTLSLGSRFLSSFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5L1</accession>
    <name>B5Y5L1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATR_44176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186203.1">
        <property type="nucleotide sequence ID" value="XM_002186167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5L1"/>
    <dbReference type="FunCoup" id="B5Y5L1">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y5L1"/>
    <dbReference type="PaxDb" id="2850-Phatr44176"/>
    <dbReference type="GeneID" id="7204096"/>
    <dbReference type="KEGG" id="pti:PHATR_44176"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508544_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5L1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACI65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="22127" checksum="5C8134B796DCD637" modified="2008-11-25" version="1">MSIKPRLTFVTGNKNKLEEVKQILESGGELPFELSSRNIELPELQGEPYDIAIEKCRIAASKIKGPCLTEDTSLCFNALNGMPGPYIKWFLEKCGHDGLNAMLTGFDDKSAYAETIVAFTKGPDEDVHVFDGRTDGRIVPPRGLLDFGWDPIFEADESDGKTYAEMDKPTKNAISHRGRSLAKLRSFLLENRSTLSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5U0</accession>
    <name>B5Y5U0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_44239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186246.1">
        <property type="nucleotide sequence ID" value="XM_002186210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5U0"/>
    <dbReference type="STRING" id="556484.B5Y5U0"/>
    <dbReference type="PaxDb" id="2850-Phatr44239"/>
    <dbReference type="GeneID" id="7204070"/>
    <dbReference type="KEGG" id="pti:PHATR_44239"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y5U0"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="635"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1180" mass="128711" checksum="8EE1380A8AAA76A6" modified="2008-11-25" version="1">MSEEPPADWRENSTGGLADPNVPVAPYPPMISARFPSHHLRSSLSHSPHYTSPTPSFIGSRAESNVSGTSSLFPGYATNVGGASTATSLEDGGTADEASRQTNAFAVTDDSAAIANIEFCRPDLLACINCVSSSSNTHTTSNTPTSLNSAKFADSTTPARSNRKMGPVLLELRKLQLNEGTHGNHDFFTTSQISVSRGNPSLGMSMSSTCLHVSPQAMRTGENALHRPPPPIATGLTTGALCIHTFVIKSDGDNENNQDWTPNVEYYHTPRHHRASTAVQWCPTTVRPQHVAIGLLSASSSGSHPTTNSVVPGRRGVSGGGVAASVGLGARSASTGDKDYCCFVWDVEHQSASRRTKTSPIYKLSHQSGVASLGWLMGGETLAIGGQLRHVQLYDLREATTSAPMTVMAHNFAVHGIVPDPHKSWQFATYSRVSNEPVKIWDCRRMDTNLTEIKIPSQSISPSSVSGVTPPVSQVHWSPLEAGFLSVAVGDAIYEFDTTTPASRPIHVNTMYARGSVLDVALYPFVAEMGTAKEASQPTHSWRTLPQSYDGSLYRQISTRFSTPYHCSVGSVQQGWQVGALHRTQGPAAIERLTAAQDEDVSAVMLRRARCIQSINYSMDPSANIQILAHDGSGVDSLLRLWSWIERVEVLCSSTETDDGWDDGMSWPAKTLMDAGAWRLLHIAGCGEGEIRGFSEHSCCSIYDSPGRRAALTSCGWAGRFDLSTVMGECEELGEYERSAALAVWHDDIGAAVDCLQRGASVIRQQMKRGGESVNMYCSSEHAETLDLVSFCVAGHRGDSMDSPASGIWRRTCATLMKRSSFSGQSRCFAYVRGMLKFLMTSGSDQGHDEVLLCDDLSLCDRVGFACRFLSWNELLQYLETCIVNCQRSGDIEGMIITGLEKEGIKILQSFVDRTADVQSAALITSRVIFPVGWNGERRASIEWLESYRSLLNTWQMWQSRALFDVDRADLLRKVKSRQFDASGKFGSVPISRRQVSAGGKPGLRQPDPDIQATIPAQLDARCNYCSAPLSLKLKDTHANQWLSKMKPVLPCCAQCRKPLPHCAICMLSMGTLNPYMELTKDRSGRSSRSGLSSLQTADDMSSLGNLPFAEWFTWCLRCKHGGHAHHLVGWFAKHEVCPVSGCDCHCQFDGIHELNRYKQSSERVTNENEQDTTSNTEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNZ0</accession>
    <name>B7FNZ0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_31652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="2850-Phatr31652"/>
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    <dbReference type="KEGG" id="pti:PHATRDRAFT_31652"/>
    <dbReference type="eggNOG" id="KOG4711">
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    <dbReference type="HOGENOM" id="CLU_832771_0_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="FHA_dom"/>
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            <begin position="4"/>
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        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="227" mass="23920" checksum="762D2A56A908C485" modified="2009-02-10" version="1">MESTTVGFSTTIDLKYGTGAAALALLAWLHSQIFVPKQLASAVILDRITEGTFLANKRLTCVYKASRDGWSAIDFHNQVDGRGSAVVVARSRSGKTFGGFNPNGWRSTDDYYDSSSAFLWSGTSATAIAKFPVLAGGNAAIFDYATGGPCFGNSDLLIGPPKAAIMGGFAGPDMENTSTNAGNLRQAKASPGITYDGDARWPVLGDVSLLEVEVYCNAAVGQQRASW</sequence>
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            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002177107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP28"/>
    <dbReference type="PaxDb" id="2850-Phatr42656"/>
    <dbReference type="GeneID" id="7196004"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42656"/>
    <dbReference type="eggNOG" id="ENOG502SZUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805258_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP28"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="14"/>
            <end position="99"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="274"/>
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        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="303" mass="34042" checksum="92381EE36027E474" modified="2009-02-10" version="1">MSRRGSILQPHEHDVLLGRGGKNNQALGNEKLREMARVEAENYRRSTKKGKSSISRKLVRQMRELDPPARFMKRNSDNSEWEDVGDEFAREKASQVLRDAVAGLPEITGSGDIGYDEERDTQPRLVTASRSRDSASRAYAEMQPTPTLQCIASSLPPPTPLAVGSRKRSRYSQHSEQQPTAYPRQGYAPHTPTVYSPPQYPYSYDHPGTYTPTHYSGFPARPPLPSFLHERINPRVATRPARVQNRDTSTASSLLGEIQEHATEFDLFNGELLASDTEEEVKESRAPSGYRRDSYGHPAPPWP</sequence>
</entry>
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    <accession>B7FP78</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CCAP 1055/1</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002176624.1"/>
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    <dbReference type="STRING" id="556484.B7FP78"/>
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    <dbReference type="GeneID" id="7196103"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31741"/>
    <dbReference type="eggNOG" id="ENOG502SE0Q">
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    <dbReference type="InParanoid" id="B7FP78"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="InterPro" id="IPR019656">
        <property type="entry name" value="Uncharacterised_Ycf34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10718">
        <property type="entry name" value="Ycf34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855138" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="148" mass="17162" checksum="D5C67425DB9CDCF8" modified="2009-02-10" version="1" fragment="single">MPHLSKIFVLWLMAFAGRTFAFSKGLASNQQIPRSTFQRTPTRSALHCICVDCARVTNCAAYHFVETKHEQPHMTDNPTFTPRDGSPTIHVDVRTIRTDDDRQAEMDRMWREYKDEEQKAEANQQEGGKLRGEKVYDFTPVTTYEYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPE2</accession>
    <name>B7FPE2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177197.1">
        <property type="nucleotide sequence ID" value="XM_002177161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPE2"/>
    <dbReference type="STRING" id="556484.B7FPE2"/>
    <dbReference type="PaxDb" id="2850-Phatr42750"/>
    <dbReference type="GeneID" id="7196377"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42750"/>
    <dbReference type="eggNOG" id="KOG2545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029811_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPE2"/>
    <dbReference type="OMA" id="VANNIQI"/>
    <dbReference type="OrthoDB" id="48289at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73533" checksum="7172BA693E379DDC" modified="2009-02-10" version="1">MISGYFVFRAGAPNPLSIARHFWIEGAHFSLGRDDGTVRHGTASIDCKRFSLDCCLTMVRMIVTQPVVTPVHSREDSAAEESHECLRKLQEGSDLSASDWEEIGREKNQIPVYSKNLPSQIKGGSLVRVRGMVQDMFEAEYFSTSLIPSHSLNGNSLAERTPLFLSPVPFTTPWYQEELNDGASSEENQDMHRSKRLRLEETGEEDQSSECNNQNRWWCSEYMKSDPHQTPVLAKFYYDQYGAQSPKILLNELVEAVGVLEWEEDVTSSSGTNNTTPVTLDDTMGAGAHTLWADEGIDTVIATTIPTDIPRLHVLWYQTFTLDQSLYESGHEDFTKDSFGGEDCHQAPNLLSQALSVSELSANLLWMTLLSQAERHVVSEESSDPHWTPVSTPDNTTLGCLSTQFVLPDTSDCRQLAQVMEHVLSQVLPAVYVVTITQEALTLLRPPAKRNGRIEPTPMQLPRGATLVLNASELEEGHLLASQIETLQSFQSIALNHSVPYEFDGGVHIAFEADVRVLVLCTAKTAKIVPCHEQVKCDFNAHRYHPGTILQTAHKLRQVLASTRNLGISHRCNPNNIALSNSLLDRAQKDFIQRRLECRQQKRSELYTEQDFHRWLTLTRLQARSRKSATANISDWERALALDDARNDEIQLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ19</accession>
    <name>B7FQ19_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176805.1">
        <property type="nucleotide sequence ID" value="XM_002176769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ19"/>
    <dbReference type="PaxDb" id="2850-Phatr32041"/>
    <dbReference type="GeneID" id="7196553"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32041"/>
    <dbReference type="HOGENOM" id="CLU_488763_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ19"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="51892" checksum="4078F5BD876A4519" modified="2009-02-10" version="1">MWKSLFTFSRRKAKREISQQSKYDQRALPEQSTRKSSRAVGPGATAIPTLIVPEQRADSDKEKANDVEEHAGDCCLSSDDLKAIAETKIISPSCTKKDGASQSQDSNSKSSSTDAKGNGHEESTDFTYFDFLGLLCGASLILELFLPRAHHKATSEATKAPDCGFDPSSEEGIEQTLMMDEIGDWAQVCNAIDGSRDSSLYNGSEKTSQAVRETGIPTHRLVPDSTDASTDDEACLKTDTRSIERHVCNTTLVAPHQIQRDTIVDVSDDQKLPSEGSNRNTEKNYGMALSGLNPKALDNQHQTASKKTRVRSFKSLLGSQRLRTNTRSQGVGIAVNGSSTSLKTKTKTGLRRGGYSNASNQRRKESGPLPPEQNRKRLGFWKKKLLNQNPGLASKNMEEPRLEAAKVSAMKAAAVPCPDRNSATNLPTVNAMEKECTTAGKDTVSRQYEAQREDWITYNATRAARTHARPCTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQJ6</accession>
    <name>B7FQJ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_8926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176883.1">
        <property type="nucleotide sequence ID" value="XM_002176847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQJ6"/>
    <dbReference type="STRING" id="556484.B7FQJ6"/>
    <dbReference type="PaxDb" id="2850-Phatr8926"/>
    <dbReference type="GeneID" id="7196864"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8926"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429908_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQJ6"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="147"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="349" mass="39938" checksum="BB26B34B8B9A28BD" modified="2009-02-10" version="1" fragment="single">MSDTAEQISIDDVSKELRVVRQEFGEKMERVTSVADAEVIRREYLGKKGPINKAMGYMRLLPNEDKPKLGAVVNEIKEALETTMTERMDALKVAEIEAAMELERIDVTQPGLWNSPDIGRRHPLSITMEKAVDIFTKLGYDTVTGCADSPEIENDYYCFEALNCPKDHPARDMQDTFYLTEDLELMLRTHTSAVQIRQLEKRKPPLRIVAPGRVYRKDDIDATHSLMFHQVEILALEKRGELNLGHLKGTVEHFLQNMFGPNIKVRFRGSYFPFTEPSMEVDVFFRGKWLEVLGCGMVDPNVLEMAGIDPNEYSGFAAGFGVERFAMVIHGITDLREFYKNDKRFLQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQQ9</accession>
    <name>B7FQQ9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176913.1">
        <property type="nucleotide sequence ID" value="XM_002176877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQQ9"/>
    <dbReference type="PaxDb" id="2850-Phatr43131"/>
    <dbReference type="GeneID" id="7196743"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43131"/>
    <dbReference type="eggNOG" id="ENOG502S6TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817521_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQQ9"/>
    <dbReference type="OrthoDB" id="5813at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855203" evidence="3">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="32586" checksum="1BA84721AD74E828" modified="2009-02-10" version="1" fragment="single">MHRSVFSAVLMVVGVASTVAFSLNRIGGQTAPPTAGRPSEVLLHATSGDNRKRKRRRKTVPGAVSPDPIKDAQEKIEGVESEANDGDGLTKDDLLNVARVANFEFNPISEIAVGIEDEKVAQKTPENVIRLPDIKEAKKKKQMEEELARMAEEEEKSKVKIKRSDKEAFRRLLEQQPFADADDSFFEEEAYGTVSALLGERAKPFIGIPTGPLQVGHFVGALGLLLMAYVEYPGFPLTNLPTPLRDCLQGGLGTIYAINTVLAVLALFKAGERGQPKWLWIAKTFSVGGLAYDQLTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR28</accession>
    <name>B7FR28_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Limiting CO2-inducible protein B/C beta carbonyic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2020" name="Acta Crystallogr. D Struct. Biol." volume="76" first="676" last="686">
            <title>Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum.</title>
            <authorList>
                <person name="Jin S."/>
                <person name="Vullo D."/>
                <person name="Bua S."/>
                <person name="Nocentini A."/>
                <person name="Supuran C.T."/>
                <person name="Gao Y.G."/>
            </authorList>
            <dbReference type="PubMed" id="32627740"/>
            <dbReference type="DOI" id="10.1107/s2059798320007202"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 261-517 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177507.1">
        <property type="nucleotide sequence ID" value="XM_002177471.1"/>
    </dbReference>
    <dbReference type="PDB" id="6KFS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.20 A"/>
        <property type="chains" value="A=261-517"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR28"/>
    <dbReference type="SMR" id="B7FR28"/>
    <dbReference type="PaxDb" id="2850-Phatr43233"/>
    <dbReference type="GeneID" id="7196954"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43233"/>
    <dbReference type="eggNOG" id="ENOG502S48Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527323_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR28"/>
    <dbReference type="OrthoDB" id="38305at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040703">
        <property type="entry name" value="LCIB/C_CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016:SF1">
        <property type="entry name" value="LIMITING CO2-INDUCIBLE PROTEIN B_C BETA CARBONYIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18599">
        <property type="entry name" value="LCIB_C_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Limiting CO2-inducible protein B/C beta carbonyic anhydrase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6KFS"/>
        </source>
    </evidence>
    <sequence length="517" mass="54155" checksum="80887B61D2752703" modified="2009-02-10" version="1">MRICMRSQSYSSLVVASMVVCTAAFQTSVVSVRRHSPLSSTIDGVDRSEAVAKLERAAELSDFLAQAYEDKVKAIETVEKQNQAEIDALKAQIESLQSQSSGAASKPSAPPKITGDLAKLSNDDLKKKLQEYEEFMAKTMADADPSIKAAIQKKQAEAAQQQQQQQQQSSTTTTATAGATTSGTGGVLGTEDLLSVGAVSALTAVATSVILDNTRRQSFGSIVAGVSAPLVAGNSAPEPTETPAPAPATVAPPAPVVVDLSQFETTMAKVQQAFPGAATNDQLVAKTKSALSRFGFGSNSLVATSFCSDEVNRPLETDFAKEFKDTFSLGGLAGFPFSGVTGFGAMAKHIPDGGSCLVVYGPHVGVDLDGNVGTVNRRGREKGGTCCGSAVAAAGYISKVFNGEADPAPAVPESSMDAQQLYVGNMLLPYAERIGNAQDAMVELPYATYEPLDDLMQKIVAKGCGKVGGDGKIALLGGLQINTPAGCPDYFLPLRFEVRDNQNNVLDNLLYEKRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRI4</accession>
    <name>B7FRI4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_8683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176551.1">
        <property type="nucleotide sequence ID" value="XM_002176515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRI4"/>
    <dbReference type="STRING" id="556484.B7FRI4"/>
    <dbReference type="PaxDb" id="2850-Phatr8683"/>
    <dbReference type="GeneID" id="7196058"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8683"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761782_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRI4"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852594" description="peptide-methionine (S)-S-oxide reductase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="164" mass="18516" checksum="D5C06A054139152B" modified="2009-02-10" version="1" fragment="single">EVATFALGCFWGAELAFLRVQGVVGTKVGYSQGITRDPTYEKVCSGGTQHREAVMVVYDANVVSYATLLGVAMERLAVTTSSYDTYRMFEQDEDSRQYKHGVYYHNPEQQRLAHEFSESSNNRFGIELLMASTFYDAEEDHQKYLYKGGQSARKGAKETIRCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS66</accession>
    <name>B7FS66_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177612.1">
        <property type="nucleotide sequence ID" value="XM_002177576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS66"/>
    <dbReference type="PaxDb" id="2850-Phatr43421"/>
    <dbReference type="GeneID" id="7197146"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43421"/>
    <dbReference type="HOGENOM" id="CLU_566813_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS66"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54439" checksum="F3AAD2143413252E" modified="2009-02-10" version="1">METFRRTFKTTSYPARNMLSNSSSALFRRSRRAGIDGADCGVVPSEDEENQFHSSRKEGNAQCPRKPSYTILWNWRWRVSAKRRVARIITVVCVFILQLCFLIIAERRVVVFGTLDLSPVVYHVARRTGLCVWQHEFAFLPAPSLVSSCKCKFDFCTVTHEGGEGTLYRGKCCNSSDGTGDPGEMQRSVLFKSTKISNRRSAWTEADATRTFTATNKSDLLLLDSGLNYLILTELAEYEFLNVRKLMNARQMDFSTVLVLLLKQVGAQLVELHRAGYLHLDVSRLNILQHSYDQSQAAATKTTFQLIDLSGAQPMHQWRRIIHGMYYDMKRFHLPKLPDLACLVADDPDARDFSAQQEYCRVRRIEGSSARLCPGLVDLYPLGILGLDLVLRFLGEESIAKRPTTSFPLSNNTTQGFAWIVEQRQAHVAAWHRLDQRLVQPPMGSYRKALRLIGDVMLISAPTNETANEFAASLCAFSTMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS70</accession>
    <name>B7FS70_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177930.1">
        <property type="nucleotide sequence ID" value="XM_002177894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS70"/>
    <dbReference type="PaxDb" id="2850-Phatr43424"/>
    <dbReference type="GeneID" id="7197148"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43424"/>
    <dbReference type="eggNOG" id="ENOG502S4WB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095464_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS70"/>
    <dbReference type="OMA" id="IPYMQRG"/>
    <dbReference type="OrthoDB" id="38535at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855367" evidence="2">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="19849" checksum="EB484B9641E89E26" modified="2009-02-10" version="1">MNFKAKFTLLAVVFLSAATAFAPGFVKHTAMKLEMGYVPDGLTEDQYRKIKMDDARKAKGKELGRLGPKGFKSRSLQSWQEAFDHGKAGHTFAPIDYKERVKQGLMKKEDVPYMVRGGNWDNSDVKGAKKLQWSKKDKDYAKGGYKKEQSASILGSGPGFDWTGMGDKKNKRNMPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSB0</accession>
    <name>B7FSB0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Rab5a</name>
        <name evidence="2" type="ORF">PHATRDRAFT_51511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177632.1">
        <property type="nucleotide sequence ID" value="XM_002177596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSB0"/>
    <dbReference type="FunCoup" id="B7FSB0">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSB0"/>
    <dbReference type="PaxDb" id="2850-Phatr51511"/>
    <dbReference type="GeneID" id="7197170"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51511"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="B7FSB0"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="entry name" value="Rab5_related"/>
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        <property type="entry name" value="Rab family gtpase"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="small_GTP"/>
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        <property type="entry name" value="Ras"/>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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        <property type="entry name" value="RAN"/>
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        <property type="entry name" value="RHO"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="RAB"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="201" mass="22359" checksum="56DE85306B978483" modified="2009-02-10" version="1">MANHPGSAANARVHHFKLVLLGDTAVGKSCLVVRFVRDEFFEFQEPTIGAAFLTQTVQLDDATVKFEIWDTAGQERYRSLAPMYYRGASAAIVVYDITNPDSFTGAKSWVKELQRRGDPNVVIALAGNKADLETRRAVEFEEANAYAQENGILHLETSAKNANNVKSLFIEIAKTLPKNAPQPEKEAFPILQQQQETRNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSE3</accession>
    <name>B7FSE3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Immediate early response 3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_10128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177649.1">
        <property type="nucleotide sequence ID" value="XM_002177613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSE3"/>
    <dbReference type="PaxDb" id="2850-Phatr10128"/>
    <dbReference type="GeneID" id="7197186"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10128"/>
    <dbReference type="HOGENOM" id="CLU_152125_3_0_1"/>
    <dbReference type="InParanoid" id="B7FSE3"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7990" checksum="84042707BD5A5524" modified="2009-02-10" version="1" fragment="single">LQAGLLLLNAVMVLNRKRFLAKYGLDDLNHIQEERNPLRSQAVGLLHAVGYLKVPVIVANLITALFEILLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSN6</accession>
    <name>B7FSN6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178013.1">
        <property type="nucleotide sequence ID" value="XM_002177977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSN6"/>
    <dbReference type="STRING" id="556484.B7FSN6"/>
    <dbReference type="PaxDb" id="2850-Phatr43565"/>
    <dbReference type="GeneID" id="7197301"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43565"/>
    <dbReference type="eggNOG" id="KOG2146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="358" mass="38303" checksum="4B62A090F4F9733D" modified="2009-02-10" version="1">MPAIKGTASVSDSRALSKALKSINFPANFSSPVDISKVNRAVLAQWIETRVTEILGFEDEIVYSTIVNVFLPTVASDSSAAQPEVDPRRAQVDVAGFLGDEEASMFVRDLWSMMLDAQDSGVGIPRKLLEEKKKELAAQAAQKAASLSKSGSSAPLEKNLPLPLPPENRRADNQRTIGNTGRMETPVKNLLAIAIVSMTMTGERKTILPEVSTMNVANETPTASIDMMTRAHSIEVPRDQGGGGAPTKQRHRGEHRSTAIAVKLNGGIGKIGRGRGTNGIKNVAAVEVVAATNMAVARDGAAIPVPRLAAIAVHHNALIYISRIDNWKRIFTPCCLCSAQEGAKLSRRSTIPADCRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FST6</accession>
    <name>B7FST6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_32850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178038.1">
        <property type="nucleotide sequence ID" value="XM_002178002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FST6"/>
    <dbReference type="PaxDb" id="2850-Phatr32850"/>
    <dbReference type="GeneID" id="7197326"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32850"/>
    <dbReference type="HOGENOM" id="CLU_001650_12_1_1"/>
    <dbReference type="InParanoid" id="B7FST6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="131" mass="14178" checksum="581959FCD5375AD2" modified="2009-02-10" version="1">MLNSKLFSKFLPVLRKKVKSSPWPQLLSTGMTVLSTGLRDGAHYLGRGTQGEPVETNLVCLVTNPDTDVFGQAQSQLSIQKHDVTVSGLNCCHAKEHGNYDECAHGAVYNTVENNGTDHDGAWQIVGPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSX1</accession>
    <name>B7FSX1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177740.1">
        <property type="nucleotide sequence ID" value="XM_002177704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSX1"/>
    <dbReference type="PaxDb" id="2850-Phatr32886"/>
    <dbReference type="GeneID" id="7197494"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32886"/>
    <dbReference type="HOGENOM" id="CLU_090174_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSX1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="270" mass="31116" checksum="19B7CFB1B37407B3" modified="2009-02-10" version="1">MGSRQHQFLVLRLKLGIRISNVVILPDNVIQRHFVDTRHGAQIIDQQLEERNPLRFFRERSRRLDLDILFVFRFFQFTHFPGVQVSNGRSKIRRNHRGPLSEALRHPQMHSAELVLPHHGNSDPRSARRRRDRSISASSWHCGHTIGTTTDDLADILETVTGDQAKGVHRIKTFVRKRVRRRNRPSDPPERTTKRISTVSSHDIKNNFNEKKEQRNNVTQSKSSCTIAKKTSRTAGADTTLQAQLPSVLSHKVSLHKYYTYPVLLTSETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT69</accession>
    <name>B7FT69_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178104.1">
        <property type="nucleotide sequence ID" value="XM_002178068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT69"/>
    <dbReference type="STRING" id="556484.B7FT69"/>
    <dbReference type="PaxDb" id="2850-Phatr43708"/>
    <dbReference type="GeneID" id="7197005"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43708"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544554_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT69"/>
    <dbReference type="OrthoDB" id="194692at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="102"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="501" mass="56041" checksum="B68F11EA0F08A6E9" modified="2009-02-10" version="1">MQEADSDNNKDEGFFCLLDGLSVGDLTSFAWENESDTETDERGDVSVFREVLSPLDSKEKTQQIRVSSASKIPVSEDHNRHIFPLAYKSSGYCTRDGKVQRPQVQVVDMGPRRGNGLITRTALRRGEVVYTEQTLMATQIPQTETINKREELFSIRACQNCFRSMEPITSCRTANSLASLPLPHLWPVSDVTLLDEAMKASSPRNGQDKFGRIQCRLCHAWFCTIHCKTIHNRKMGSCCIATQALESLLCFRDIDEPYEVQAAVTWAVRMFVAETQRFRVSNTLLGSLLEGFCGEASDLTALELGILSKHENGLLWTYTLQPIYESLVRLLRLTPDEQESLSLMFLHELASKAGRNGFGMLTQSPFKAYYAGILRNSGGRGSKRHEGLMKQVAQALGSQRLERGMDRVVEDKVAPEIVAVFPLTARINHSCVPNAQVQSQEFVDARIDVVALRDIAAGEEITISYIGCGRTSGSKSTSRRRRELLAKYLFTCECPRCTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTI4</accession>
    <name>B7FTI4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_33664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178420.1">
        <property type="nucleotide sequence ID" value="XM_002178384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTI4"/>
    <dbReference type="PaxDb" id="2850-Phatr33664"/>
    <dbReference type="GeneID" id="7197991"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33664"/>
    <dbReference type="HOGENOM" id="CLU_1172644_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTI4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="237" mass="25880" checksum="A55CB025236B9AC8" modified="2009-02-10" version="1">MANPTVSSVWSANSQAVLCMKNGSNAQALRILASAIDQLQNHLVAIPLHQIRGDHPINICFVSESTSGGSMCPAVQSPLADDFSIFVPMFEWSFVTQPGQGKIPDGIPGSEIVITACLLYNLGLAHERLGQDTGRDSLFIRALNIYKKAIRLLMDYGSLRANHSVTFIYLALLTNTIRIQGNYFLQAERAQAVVMLRSALDYISPDDLSEGAHTSFYTNLWMIDQFNTMLPAASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTQ3</accession>
    <name>B7FTQ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CXXC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178457.1">
        <property type="nucleotide sequence ID" value="XM_002178421.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr44324"/>
    <dbReference type="GeneID" id="7198023"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44324"/>
    <dbReference type="HOGENOM" id="CLU_243009_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTQ3"/>
    <dbReference type="OrthoDB" id="57231at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1594" mass="174381" checksum="07B720FCE2DD4297" modified="2009-02-10" version="1">MPSILDIATSSGLEANSVTLETPIAPPPSLPIPPTMVANPVDEIDNFKTNGNAETQKELMVLAPTLEDIVAGGIATTSYSPEELARLQERPVVNIKSLDDTHSDSSRRCNIAATDPIPEFEDSKVALGYEDNKAIELLESNNECVVSTSNKGNGLPGLELANTATNDPELPHSKCKNVATALGASTESSDGFRLTSPNEIDQSSENGHPEKKCQSDRMVSTSQVHLSGQLESSKSGLVSVPISGVTPGQNDVDQQPPDEIAEMQEPLAVVAPARKETVTPEHSPTTKLSAEAAQLGKSQDGKIDFSKITYTDAAAADSKPEVEQAMVVLGCEENPLVNVMSVSVFSASKDVTKDPQAKSLDTTAHSVEQPHHESTSKTVTGSAESTDGVKWLYSTSPIKLDSSSEDEDVEKNTESVRIVSTSEMCSSGQSESSKSVLASVPSSGASSGQNALDKQPFKPANNGEKEVGAVLTAKSDTQKGVDKKMQIIDSVGSIKGEERGIDSLLLVSTSAGDLPQGDSTSSVPTIIEIDLAMPETEFAQGENSSKTRTRLSGPASAAQGLSSTGTKFKAPHGKRSCPETRNARLAPVIGEQTFQGNSDGRTSSVAESSMSLSMVHQNKITSGELHSTALPMSKETPTKSTETALKFSLSRRSAVKSPSLKRSASSNKTLAVGTAILQDKPMIASTPLGADSASVLWDLEHSNLSRKKRRYTNTNADSPHGSCHLPVNNQEVIVLLSSSDDDQSASEASNLNGIQTNVAEKLEPSVSSEKEESFWSFMFQDESIEDSCLTMQDADEDDTVSECDIPNDCTHSKHVQGLAPSENHASIRPPGVNAAKPCGCCLNCIRASCGMCNNCILGKRQSCFQKVDESDSAVHAPSFPSGWRFYFGQDKKYCGLFILGPGGLRYKRAESAVNRSPSALRNVDIQHFYQYVGLDDTRATNERTNQKSSSSMGVGVRCYAMYTNRQWYWGTVLFDDGDTRDRVPFGNGLELITESEYRNLYPTQIIPKRPSRLEQSDTEQDCTVLNARDLRRRRCHNCSACRTESCGFCFSCVSNKENTTLYKQQCFLTVCSQIKVSEKAHAVPRLDSYTFYFDNEKSDRCPRWLPPKLAGLVVIDANGSTQRFTKSSKPCTLFDSRSKEVQDFYEGFLGIPLREQNVEHTLVGKGFRRDWLDVNGNCKTLSGIISSCEKDIFSGDYYFTITYDNWSLSFLDYRAGKVPQPNKGIRCERWICPDACKVSAASVTSKNFPHMCLSVRGFLLEFQVKKSTIKGAGLGVFVRCASMNDSLKAEGLVLAAREYIDLGIYAPLVPEQKIPEHVNLALNFVHEWKCEEWNFSLWGHPTGWIYNISDVVTGELSTSSRQNLLSYVNETDGKEAPLIRAAHDPEGAVHYLLGFEQGDNLHLPLDSNWMELKINYGSGYEKVRVRKGYSRLSHSEQEKFRELIASDDKDTLDDVMKWSAQDLIQCLTKFEESFVIQKGDTPLREIAAARAILIVIQFKERIKSFQEEFATLDDDTSFCDNGYTDLEKLDVVGRCTRLLGALLNSGSTRTQVCKFILKTRELCSTLATLLKWTEKMLATMSVSRLRKTIVGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUI9</accession>
    <name>B7FUI9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkgJ family cysteine cluster protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178604.1">
        <property type="nucleotide sequence ID" value="XM_002178568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUI9"/>
    <dbReference type="PaxDb" id="2850-Phatr44566"/>
    <dbReference type="GeneID" id="7197806"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44566"/>
    <dbReference type="eggNOG" id="ENOG502SAAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1028416_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUI9"/>
    <dbReference type="OMA" id="CEGMMIL"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866:SF1">
        <property type="entry name" value="YKGJ FAMILY CYSTEINE CLUSTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30507" checksum="9F6EE92CB2431899" modified="2009-02-10" version="1">MNILSLGRSLASFIVVYGGIDLVAVHAFAPLRSLSADGLPRRRLTSRFSAGVDLKQNEDLQKYFQAAEERSLAQFARDDAPAWLQTIASLPFECTACGKCCKTIGSVYLSSEETWQAAELMNISSTEFIEAYASDIIRDSAEASNTWVRLKEKEVLKGTDHSPACIFLNSDTNQCQIYEARPTQCRTYPFWPNLLASPDAWDAEVRRMDHDSESTLLEWTPDAGGCEGMMILDQNSTTLGVPMKDVYRQLREYRQQDRYFPTGDKKADTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVK7</accession>
    <name>B7FVK7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_8310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178948.1">
        <property type="nucleotide sequence ID" value="XM_002178912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVK7"/>
    <dbReference type="STRING" id="556484.B7FVK7"/>
    <dbReference type="PaxDb" id="2850-Phatr8310"/>
    <dbReference type="GeneID" id="7199736"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8310"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462717_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVK7"/>
    <dbReference type="OrthoDB" id="424673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021995">
        <property type="entry name" value="DUF3593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35473">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35473:SF3">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12159">
        <property type="entry name" value="DUF3593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="77" mass="8441" checksum="427EB1B00C01899C" modified="2009-02-10" version="1" fragment="single">FQASLLPYLLFLYFLSFRANRISSLGNFGFQFVLLFVVSTIPSGIIAKTVYGTSLANVDWLHGGAETLLTLANILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWB2</accession>
    <name>B7FWB2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179351.1">
        <property type="nucleotide sequence ID" value="XM_002179315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWB2"/>
    <dbReference type="PaxDb" id="2850-Phatr34656"/>
    <dbReference type="GeneID" id="7200069"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34656"/>
    <dbReference type="eggNOG" id="ENOG502SVPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633820_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWB2"/>
    <dbReference type="OrthoDB" id="53696at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="433" mass="48147" checksum="F2C20DAC07B46CAE" modified="2009-02-10" version="1">MRGWIREGGAAVILGLSAVYYQQQDGGDRWGISRAVEIMDDDWTERIGVVRAQRSRLAYFQCLDVLPNEASKPFDIAPFERAPVVEACCRAFAKLVDEPQRLLVACLATAAYGGHVRDKEESCSDRNVPLVAFLYETAPRSVTTSWSVPDTPISFHDAESLTNSTDPQPWIYSVYDKRNQLCLMELSSTDKDTDCASLLARLALDSIDSSENTQLNAFVASTLSSVGGLHREWQHQFTVSFGAEITAVETGYLTLEYLLHVGSDVFVNVEDAVQILTLPFLDDDDLRSRWNISIQHDPYRVIDQEEPAFVSPQHVVLVQLQGPMTRHPGADQPMVFETVTKLHLRYPEPLDQGTCNFVQFPLMPPNLLQASFVTASGQRYQQHGSVLPRAPPVGVWIATGRASDYIWVVTVSVLASVVGAVVILRDLHPIATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWJ9</accession>
    <name>B7FWJ9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179395.1">
        <property type="nucleotide sequence ID" value="XM_002179359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWJ9"/>
    <dbReference type="PaxDb" id="2850-Phatr45130"/>
    <dbReference type="GeneID" id="7200320"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45130"/>
    <dbReference type="HOGENOM" id="CLU_1879469_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWJ9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855535" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="136" mass="15968" checksum="9BA7A79F1AC79D20" modified="2009-02-10" version="1">MKVFFVFVILSAFFSMIYAKTVKERLMDFRHVSDTEPSPEALAALQAHDNKRMSQLQVMIEDRRRQLMDHKNGRRHLNVDEHATVADQADVYTRKLAQMRSETALDKEEKLREMIDSFKHMNRMDYIDFGKSGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWP8</accession>
    <name>B7FWP8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179200.1">
        <property type="nucleotide sequence ID" value="XM_002179164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWP8"/>
    <dbReference type="PaxDb" id="2850-Phatr34794"/>
    <dbReference type="GeneID" id="7200346"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34794"/>
    <dbReference type="HOGENOM" id="CLU_081702_1_0_1"/>
    <dbReference type="InParanoid" id="B7FWP8"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="265" mass="29540" checksum="9E37BF8CE9B71602" modified="2009-02-10" version="1">MSGTTATASPESSAPLRYAPGVLTQWTIGMLVAHAVSAAMTVAVLTAAWNQPSRQAAMAFYGVYHRNPMNQLIHFFGVPAILWTGFVFGAHLPWSPALMVPRVAPPLLPDIPKHYVTYATVWCLFYTFYYIKIDPVGGLLYAPFLYGMYASAVRWTLTDQTNAKHEINKPPPWTGTGKVLWWAILVHLLAWYVQIHPGHKMFEGAQPALLQSLGASFSSAPLFAFYEGVWFLGLRHTFREQVRDLVQQYTIELCQGGSTMRACTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWY9</accession>
    <name>B7FWY9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179464.1">
        <property type="nucleotide sequence ID" value="XM_002179428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWY9"/>
    <dbReference type="PaxDb" id="2850-Phatr34884"/>
    <dbReference type="GeneID" id="7200114"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34884"/>
    <dbReference type="eggNOG" id="ENOG502SKE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057612_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWY9"/>
    <dbReference type="OMA" id="APERINC"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="125"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="401" mass="44510" checksum="26ED97ECD98B70B9" modified="2009-02-10" version="1">MSLLIKGGSSLTVVSLVVSKRTPVARICKPSIWDSRVGFCRRTNKNRLYTTSNIASQEATPSSTSVSDRKLLPFETTPLGRNGAAQMDGLDLYQVPADDDHPLSVYGIQSTTPVMFDKGSSLRPVLLLHGRTWSAVPVYHLLGGTQYEKNGQQSRSLMEALLAKGLQPYTMDFRGFGGTHADETGYVEPSRCVQDTEVVLEWIARRHGMVGKEFPALFGWSQGALVAQLVAQKTRPLMSKLILYGSIYDPMVRYPREPLYSTSKPNRTVIENTFDNAIEDFTIEGSIAPEPARLFAEAALQSDPVKAVWRHLYQFNNCDPGRVHVPTLVVAGDQDPYAPLHVQQELFCNLGRASDRTWSILADSDHAVHLLEGRERFISTVVSFVKNGKRSENDGGQDYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX15</accession>
    <name>B7FX15_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179477.1">
        <property type="nucleotide sequence ID" value="XM_002179441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX15"/>
    <dbReference type="PaxDb" id="2850-Phatr34908"/>
    <dbReference type="GeneID" id="7200272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34908"/>
    <dbReference type="eggNOG" id="ENOG502T4FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1664127_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX15"/>
    <dbReference type="OrthoDB" id="49066at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852774" evidence="2">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="159" mass="17802" checksum="F84B3402BBBB6513" modified="2009-02-10" version="1">MNQLLFVFAFLCLSTVSSFTIPVRHSDQRAVLVFAGTKEDEIAALEEKLRRLKEDEDQKMKEEDLNVFAADQRTLERVRGKDMLLSEQELIEAQIMEKQDDSDGNIVPKVAAALGLAVALLLFAQIPVGQEDYQKYSVSGSSTVRTIDLGDLNRDVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXJ8</accession>
    <name>B7FXJ8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179782.1">
        <property type="nucleotide sequence ID" value="XM_002179746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXJ8"/>
    <dbReference type="PaxDb" id="2850-Phatr45400"/>
    <dbReference type="GeneID" id="7200497"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45400"/>
    <dbReference type="eggNOG" id="ENOG502QUYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040972_2_0_1"/>
    <dbReference type="InParanoid" id="B7FXJ8"/>
    <dbReference type="OMA" id="PSPFCKI"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45288">
        <property type="entry name" value="THIOREDOXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45288:SF1">
        <property type="entry name" value="THIOREDOXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855147" description="GST N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="38011" checksum="685442606D5A0F69" modified="2009-02-10" version="1">MSTMQCWLAILLNLSTLVSAFVPALPNNVAVVCTKVNLFNAISKPQTPKVQVPEDFEIPEPRPLSVTEGTDVSKLLKNSLGLVVRLGTGAFVLGWQIDDLFYKGEEYSLKLGPLSLRDSSSVLADAPRPSKPLIVYEYDASPYCKRVREMVNILDLTVEYRPCPGARQGAFSEKLFKQTGRRTVPFLVDPNKGVEMFDSNTIINYLVDTYGPAREVFDRKALWPVTAEGFAVSTATTTAVLAGMPGAQRQKNARPDNENMQPLEFWAYECSPFCRPVKEKLCSLCLPHTLVSCSRGSANRDRMVEKTGRFQVPYLVDPNTGVDMFEGAAMVDYLDKVYTIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXK0</accession>
    <name>B7FXK0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179783.1">
        <property type="nucleotide sequence ID" value="XM_002179747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXK0"/>
    <dbReference type="PaxDb" id="2850-Phatr35099"/>
    <dbReference type="GeneID" id="7200524"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35099"/>
    <dbReference type="HOGENOM" id="CLU_668124_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXK0"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="204"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="412" mass="46904" checksum="D47B729BB9F49864" modified="2009-02-10" version="1">MVLFQHRSQPSRPTLAVCVRDPSLTSVTSQDSEIDSTTPAHGTRRRHALVRWRSRREISTVASTAPHHPNLPRPHGPTLRPLERSRSLASIIKPASVRSLVQRPSPDRHAVYRELGMGPLRFAPAPDVPSTSLHDLTVPQRLVVRILWEQWRDRNPADVSAEWEHWCLCFARCSPGAANFDSRNAWKVMKHFDKRYVNLKAVTLESRLAAKTVVPVPGLRTHQGLDVVYVRPSRFHPKTDNVPAILDPLVYVLMNMTVTHESASTNGLCIVLNMEQWTMRHYTTDFLRRFWAVFQGFRAPVRVRQVLIVDPPSWFATIGRLMTSSMMTDDFAARVHRTPSAALGQYLADGYTQHLPDDMVGGSVPTADLVRDYLAFRKYVEAVEEVPPSTRPPLTRGFQSERRVRFEFPTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXT9</accession>
    <name>B7FXT9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_19937</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179824.1">
        <property type="nucleotide sequence ID" value="XM_002179788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXT9"/>
    <dbReference type="STRING" id="556484.B7FXT9"/>
    <dbReference type="PaxDb" id="2850-Phatr19937"/>
    <dbReference type="GeneID" id="7200572"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19937"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FXT9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="381"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="569"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC48810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114638" checksum="F24181B1131A807B" modified="2009-02-10" version="1">MPSTNKTETIQWCSDALHDLLGFADTALASYLVSVAKKATQSSEIVQILVDGDVRDVTPERMERFAEQLLSHARPTPKQSHGGPASRQAKAIHSQTKTNADWVKAASSYQLIDVEISEEPSNLNKPSDRRKGKKDRQDKRDSSLSEPLTPAERVELEREKDLKERDELVQRMMERDQTKTKQKAKSEEKSDSLTLERLREESRRAYLKKREERELALLKQSLQDEEDLFRGAKLTEAEKKRIQMGKQILSMVEERDGEEDKDDEFYRLPGDFHEKHSRAKQQEALLTSRYNEPKLEKSEQDLWEESQTQKAGAIGGRQKKAIESDGYELLFDDQIDFVMQETREGYDKHESLSEMRPATEHEKILEGRTKLPVYAYREEFLAAVKEHQILILVGETGSGKTTQIPQFLNEVGYGELGKIGCTQPRRVAAMSVAARVAQEMNVRLGHEVGYSIRFENCTSPKTILQYMTDGMLLREILTQPDLASYSCMVIDEAHERTLHTDILFGLVKDIVRFRSDLKLIVSSATLDAEKFSKYFDDASIFMIPGRMFPVDTYYTKAPEADYVDAAVVTVLQIHVSQPLNGDVLVFLTGQEEIETAAETLSERSKNLGSRIPELIICPIYANLPSEQQAKIFEKTPSGARKVVLATNIAETSLTIDGICYVIDTGFNKQKTYNARSGMESLVVTPISQAAANQRAGRAGRTQPGKCFRLFTAWSFQHELEPNTVPEILRTNMGNVVLMLKSLGINDLLNFDFMDRPPADALIRALEQLYALGALNDRGELTKLGRRMAEFPLDPMLSKSVIVSEKYECTSEVLSTVAMLSLGASVFYRPKEKAVHADTARLNFARGGGGDHIALLRCYSEWAASDFSPSWCFENFVQVKNIKKARDIREQLAGLCDRVEIDHTVSNSDDFDATLKTITAGFFYNIAKLGRTGEYQTAKQHKTVYIHPSSVMAKEEEPPPWLVFFELTFTTKEFMRQVAPIKPSWLVEIAPHYYQETDIEDSKTKKMPRTRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY28</accession>
    <name>B7FY28_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_7966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179667.1">
        <property type="nucleotide sequence ID" value="XM_002179631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY28"/>
    <dbReference type="STRING" id="556484.B7FY28"/>
    <dbReference type="PaxDb" id="2850-Phatr7966"/>
    <dbReference type="GeneID" id="7200622"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7966"/>
    <dbReference type="HOGENOM" id="CLU_231251_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY28"/>
    <dbReference type="OrthoDB" id="48634at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="59" mass="6933" checksum="2479E4E0316056CF" modified="2009-02-10" version="1" fragment="single">FLLPVNDYRYSDYPSRVEVPMDLTFVLNRLEADYYGSRPSVVADVRLIRDNCIKYNGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY78</accession>
    <name>B7FY78_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_35332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        </source>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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            <begin position="24"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYY2</accession>
    <name>B7FYY2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
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            <taxon>Phaeodactylum</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180248.1">
        <property type="nucleotide sequence ID" value="XM_002180212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYY2"/>
    <dbReference type="STRING" id="556484.B7FYY2"/>
    <dbReference type="PaxDb" id="2850-Phatr27385"/>
    <dbReference type="GeneID" id="7201101"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27385"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="B7FYY2"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="45"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="382"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="498"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="697" mass="80042" checksum="A008493509C9AA66" modified="2009-02-10" version="1">MSDRETSGTMDAEYSTVALKGRELEWAVNSPELLASHKAVNGSIIRTRFPPEPNGYLHIGHAKSMNMNFRLAFDKLGVPEAHRRTIFRYDDTNPEAESAEYIDSLRRDVAWLGWTPERTTYSSDNFQQLHDYAVVLIRKGLAYVCDMTKAEMEIQRELAMKRANARNTGKDPDVECPIPSEDILPGRNRNTSVDRNLELFEKMKLGFFNEGSYTLRLKMDLESSNPNMYDLVAYRIKYTAHPHAGSGWCIYPSYDWTHGTCDSLEHIDYSICTLEFETRREPYFWILWALDLYRPNVYEMSRLNLQYTVLSKRRLIKLVEKGWVRGWDDPRMPTVSGLRRRGYTAHILNSFCSDVGASRASNVVEITKLQQTARVNLSDLSRRVMAALEPIEVVLTNFGTETAQDATLTFEVQNSPTDVSLGFHTVTLTPTIYLDSADFRLEDSPQYYGLAPNKAVGLKYYGGNLVCEKVIQDKDGNVVQLEGRLDKSENREKPKTYLSWVPSDGIRCEVRVYNELFTVPEPSDLWEDEVNTESEIVHQQAIVDPSIRDVVCVHDIDKWKSNVSLQFERLGYFVVDYETTYNGATNEGHLIFNRTVTLKEEVFKKKLTKEEEDKITARKAQTKNDLEAKGIRMQIDALNLFKEAEEYRGKYSKYDAGTGVPTHEVDGTELTKSMMKKLAKEQVKHKKQQLAWNKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ01</accession>
    <name>B7FZ01_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF501 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180068.1">
        <property type="nucleotide sequence ID" value="XM_002180032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ01"/>
    <dbReference type="PaxDb" id="2850-Phatr35692"/>
    <dbReference type="GeneID" id="7200973"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35692"/>
    <dbReference type="eggNOG" id="ENOG502R7HU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853823_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ01"/>
    <dbReference type="OrthoDB" id="46395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163:SF1">
        <property type="entry name" value="DUF501 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36401" checksum="1006405741368A82" modified="2009-02-10" version="1">MSSTKNAYHDPTLPTTSISRVVPYKRKVPGRSARRRRKKLLDIQRAVSAINDSQTGSHCPIDKPSVIPQDRSRVWPAVVEKRNEFGWNNDDENLLIAQLGYLPGNAIRVTCRRTHSEELTGSPHEESSTGNDDPVVVQLYPIVLREEYSGGKSDGRKFKGRKRQKLQPLDDDQQGTSGTPMDGIVLEPFPTMYWLVNPLLRAQISKLEVEGYGANFQQRLAENSDELARMKRAHDAYGKERLDLLTAPDRQLIQSRRWESAFAIDRGVAGIRNFGSVKCLHAHTAHYLSGNSDNLIGQWVMEAIASKAEVGTNGVAALKANEESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ52</accession>
    <name>B7FZ52_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_45915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180088.1">
        <property type="nucleotide sequence ID" value="XM_002180052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ52"/>
    <dbReference type="FunCoup" id="B7FZ52">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZ52"/>
    <dbReference type="PaxDb" id="2850-Phatr45915"/>
    <dbReference type="GeneID" id="7201004"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45915"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266637_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ52"/>
    <dbReference type="OMA" id="CSGNFFK"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1242" mass="133656" checksum="76C282A044C66FF7" modified="2009-02-10" version="1">MAVLTAFPSLDATLRFFCLPYLPLYSFVCLSTINSTKHMSEFLTTDVLDALLSASHVERQAAEAVLRNWTVDQRIRALLQALTQQPSTNLPQSQAIAVREPVSRTEHHQQLLAVLLRREIQQSSHVALLHDAMEPLLQRIVTHSDSPGVSTNVVGDCVAEIVSVTAALASHDDGVRLVRRILSSVAEPASHADLSSLKLLVAVAERAPTVFAPAVADDVSTLVSTALRHAIHTGPPTASQVQHPGNVIRILTDLVVATARAHESVHSYGDSSGTTLDPNTRSSQLGRTCLVPLLETIRHVHDRDVVSKLLQALTSAAEHVPALLAGSPHTLPILVTVLSDVAHDATDTDVDLQLQAVQVLASLVEHHNVKHHRLTPQLVQAILQGTNGKHGVVQLCLHAMVHGTDDDWDDEPLVWHQYSNDNASDETAAFAQELLHTVLQALGKLALDVVLPSVERLCSSPEPTAVRAGLAALQVAVQAAPVSIQPHLPVVGRAALTWAAPTHHSFRVQFQATQLAGVLCELPGDATVRTLYGPQLLQALAVATGSPCPHVAAVASTAIVSYCRGDGITEVDAAQFVVPYLTDVLHALVHGPLSLSRTDRSQVVVVIRAVGAWPAWRKLPVPPLPPITPTSFLDAATGNPELAHLRGAALEAATIIGQALGDTHRELFVADAVNMMDWAVPYLNSGATHVPLEQLLSACARVASVLGEDYAPYAGVVLPHLMQRATAAADMEVTEGDQAGWDATQRQQVVRDDEQGTESMTIAIPGRGLAKVTVNTTRIQEKAQAVRAIYEHAVALGAAFPQSEACLDAFLELVRFPYSAEIRAVSAQTLAAIYEASCAHGEDGGMRVPATYLPLIAQGIATQIYEQDEADMDALYAMADSLSEIYYSIYRRLAKFGPVLLEKFTVGTASATVQLFMQAMVACLERRRETADILSGSPQSPLGEDEHAEYAELLRLEETLLTPLVDAVGYTLKFLRHEFLPIFEAHVLPVLGPYLSTGNDIRARLATVCLFDDCVEYCGAAAAAKFAPMLMEGALLGMNDASNGQDEELLRAAIYGIAQIARYAPSSVLAPHAHSLVQHLATISSQPKDEADNVAIHENAVSTLASLVLIGNAPFRGSAFVKPETALHIFLANLPLREDADEAKICHSGLCDLVERNTIDVTETCQELIRIIGEILVYVDDEEDLASPETLLRSVGILFRMQKEVHGDAMQRAFASIPDEAQAAINNAMQQHSRQFNCVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZP0</accession>
    <name>B7FZP0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179978.1">
        <property type="nucleotide sequence ID" value="XM_002179942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZP0"/>
    <dbReference type="PaxDb" id="2850-Phatr45750"/>
    <dbReference type="GeneID" id="7200899"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45750"/>
    <dbReference type="eggNOG" id="ENOG502SCEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475291_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZP0"/>
    <dbReference type="OrthoDB" id="198528at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="262" mass="27752" checksum="69A4444789118C3A" modified="2009-02-10" version="1">MTSPDGMNWTSQRSASQAEWRSIMYGNGIFVAVANGGMDDNHVMTSPNGINWTMQESPPEIDNWNSVTFGMEKFVAIGANTEEGETAMTSPNGMDWTLATTTPLGTWSSVTYGNGIFVAVDLFGMSGNQVMTSPNGISWTTHASPVAGWFSVAYGMDLFVAVAYLGEGTNLVMTSPNGMNWTIHQSATIAAWTSVTYAEAEQIFVAVAGGGVGTNLVMTSPNGMNWTIQESAAAAQWISVTYSNGTLVAVSLDGKVMTSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G028</accession>
    <name>B7G028_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180403.1">
        <property type="nucleotide sequence ID" value="XM_002180367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G028"/>
    <dbReference type="PaxDb" id="2850-Phatr35989"/>
    <dbReference type="GeneID" id="7201340"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35989"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641704_0_0_1"/>
    <dbReference type="InParanoid" id="B7G028"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="255"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="434" mass="48867" checksum="76904F8DF3D4D74C" modified="2009-02-10" version="1" fragment="single">MAKAQKNSSSRSRLTENPVFSDLLGSEIRMSKARAWCEPIESKTLYLSGDERYEVWTIKAAERPHLLDVCSTDSNHQQENTNEDAADMNEILALTDGCDVSGWRKEKFVRTNAEVLSAFNVGSGCVLLRRETQLPIVLSSIASSAWDSLRDRLFQEPCTTASRQLYSSNRALHPWFERENVPVILDGCPAIDKWAAMKSCRFDNLVQRYGDLEWRFSDTHGETITLKTYQKYLRSIEGSTDDAPLAVYDSQFGGDDRSSLLDDYTVPSCFDSDLFASAIPNEDDRPPFRWLLIGPARSGTGLHIDPVGTHAWVTLIEGCKRWILFPAGTDPEAIHMRDPQIPSAIWFRDFYDQAMRDHADAVEVLQRPGETVFVPAGWPHLVLNLELSVAITHNFATEYPSLFLLNKAIAQAEPELAGRFEIALKSSRPDLFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G089</accession>
    <name>B7G089_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180435.1">
        <property type="nucleotide sequence ID" value="XM_002180399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G089"/>
    <dbReference type="PaxDb" id="2850-Phatr46157"/>
    <dbReference type="GeneID" id="7201245"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46157"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482763_0_0_1"/>
    <dbReference type="InParanoid" id="B7G089"/>
    <dbReference type="OrthoDB" id="59899at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="248"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="565" mass="63344" checksum="86A5409A0E0A518A" modified="2009-02-10" version="1">MFSCCRNSTSAIQTEKEGKTESLSRTNTSQANLVRRTSVYFDSAKDSSDIQECIPSDDDSEIFMDAVQDLKDMYPIITTSYIPPAPRRVSMLEPDSMLRATHLNEPDTILQAKPVQQRLRLPPVLEKRSSSRATRKAQRRPTAAAKQDLVNPHVVIQERGYPGQLSNDELAQAQKFYRAIHGDDAAVRDIVYSLNTVEEEPYAICRFLRATQFDADKIVQRLQDGLDLWKDASAANFYPDLSDAIGAPVPVFLQFYPYCYFGTAKNGCPVSYFKAGRFDVEGLLAMTTTDKTASYFWHSNMYSFRDLLQKTKESQPEFVRCEAINVIDLTGLSASQFSNDTMDALKIISKIGDYFPETMHCLIVLNAPTWFSMTWRIIQGFIDPRTAKKIQVFGSETKGRNRLFELVDESEVPTDFGGKAGSTDLTIRKLAFGNDWNKRRLAVDLMHVKRNGKSKTFEWTLNANEEMTQVQVFSRSVTPCSITLTQKGGAVVADQVAIERPHGNTTFTAAKEALPFVTTIPMANAPIRGPGTFTVEASDNKESSTVNKKLPSGFFLFVADIRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0E3</accession>
    <name>B7G0E3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180666.1">
        <property type="nucleotide sequence ID" value="XM_002180630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0E3"/>
    <dbReference type="PaxDb" id="2850-Phatr36105"/>
    <dbReference type="GeneID" id="7201172"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36105"/>
    <dbReference type="eggNOG" id="ENOG502RYM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G0E3"/>
    <dbReference type="OrthoDB" id="46714at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="419" mass="47527" checksum="05869E71EA9D3B8E" modified="2009-02-10" version="1">MDVSQISRKERSKASTSGKFRIHLLIILLFSTALSAISIVSSILTHFSDPVNFISAVFLPSSRANASMVSSSEVSDDTLSSTYRVKTETVVEGPAQSMYLPAQPSSMILLRAIGNALPPRHSPRQTLDNLEFTLAHEKAFPNTTRHWFVNRIVDPKVREQLLCRLRKANETYTIIPFNIQVYGQLSKIPTLNATEPNRSRTLAHRGRFAEEEKKHEKILYVINVNGVRNAMLEYGRRHTNAQYILPWDGNCFLTQNAWSAIQSSLTMHPDDKYFLSPMDRLKEPNEALLSESYKPNAVEEPQIIFHRTALARFNENLRYGRRNKVELLTRIRARGPWDTALWDWQESEVRSLDTNPTPDSSADVPVAGWSVRLYSGKDGAEQPGAVALRGSLRRKAVSMLLTRLDHDYSAVNEHQRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0H0</accession>
    <name>B7G0H0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180676.1">
        <property type="nucleotide sequence ID" value="XM_002180640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0H0"/>
    <dbReference type="STRING" id="556484.B7G0H0"/>
    <dbReference type="PaxDb" id="2850-Phatr46214"/>
    <dbReference type="GeneID" id="7201286"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46214"/>
    <dbReference type="eggNOG" id="ENOG502S5R1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671704_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0H0"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="367" mass="40296" checksum="4C0425413A6C4DB5" modified="2009-02-10" version="1">MLMKPAVLRNTARHSTQTEWVPLDPESLVAAPCLIEQTLCVADESVHQPRRAKDFHYAKAVLDAWKQQELDEGDSVWSAETCRVQYAATYGSDSERDPNPGKQPSLLHGHLIRKGSSGALGTQSSTPRPGILFFHTGAGPQDLFLFWKAVALVQKLDCVVLIADILGDETGWAWDADRSRYQQAREHVLAQKNTDDPNDDESRSRPELRARIRAALDVLGKQDEIDTDRLGAMGWCLGGYPILELGQMNLPSVKAMAAFHGVFGEDERAHGSNLPSPEGSASGEGTADIIICHGVEDPFVSNQSLEYALETLQAHRHRTSLLQLSAKHGYTNPAQDFNDNDAFAYNAEAANKAWNQAVNLFVRTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0I9</accession>
    <name>B7G0I9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GrpE protein, HSP90 cofactor, chloroplast targeted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GrpE</name>
        <name evidence="10" type="ORF">PHATRDRAFT_12896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180686.1">
        <property type="nucleotide sequence ID" value="XM_002180650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0I9"/>
    <dbReference type="STRING" id="556484.B7G0I9"/>
    <dbReference type="PaxDb" id="2850-Phatr12896"/>
    <dbReference type="GeneID" id="7201295"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12896"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0I9"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="102"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="525" mass="59590" checksum="C4C66EF6B51354F5" modified="2009-02-10" version="1" fragment="single">EQLKSDYTQSRPYPHGIFKNIFEPEFLKSVLTEVKCNSQVNFKESDLFRVYQSIDLANVAIDDHSNQEKLPNTIQLRQFLYSDGWRHLIEDVSGLERGTLNEKVDCAFNCHTTGCHLLCHDDVIGTRKISYILYLTDEGWKEEEGGALELYDSVEYGKGEAKQRLPNCVPSKTILPLFNHMGFFEVRPGFSFHAVQEVFGDRPRLSLQGWYHTDKPPKGIGKATLERLKATSDHFESPFTPVEIPPHSLMSATTDVCILFNEDLNFLRKYVHPVYLNPDAIREINQRFEEDSSVQLRNFLLPHWVDKLRKATEEEKQESSDGYTAGVTKDWKLVGPSHKQRYLQYTNRISDDSADLVETGEILAHLQHVLQSSVFLRFLLSITSLSPTSYRGHVRRFRPGLDYTVAHYGLLQLTSVLDATLCFVAGQGEDVAETDDPLEADVAWQSGDVGAFECYIAADDEEGSEAAADEYHEDDDTGLLSVSASNNTLSLVYRDPGTLRFIKYVGSQAPSSRWDISMEYQVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0M8</accession>
    <name>B7G0M8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetrapyrrole methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_12925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180504.1">
        <property type="nucleotide sequence ID" value="XM_002180468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0M8"/>
    <dbReference type="STRING" id="556484.B7G0M8"/>
    <dbReference type="PaxDb" id="2850-Phatr12925"/>
    <dbReference type="GeneID" id="7201469"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12925"/>
    <dbReference type="eggNOG" id="KOG1527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G0M8"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004790">
        <property type="entry name" value="PRK06136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="255" mass="27368" checksum="7BCBB9A2FC88786B" modified="2009-02-10" version="1" fragment="single">VGSGPGDPDLLTVAAYKLLTSDPDALVVADRLVSPEILALIPGEVKVARKLPGCAELAQEEIYWWCYQGLNQGRHVIRLKIGDPFVFGRGGEEILAFRDFGVEAAVVPGVSSAFSAPLLGGIPVTHRGVAQQVVMCTGYGREGSSPDLIQYHKEQTVVFLMAVGRLRSLCDKLIELAGYPRDTPVAIVEKAGCPEQRTVVGNMMTIADIAEEHKIKPPSVIVVGEVVNARDNVPPRALHALDKGLPALKSFFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1M1</accession>
    <name>B7G1M1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_36534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181053.1">
        <property type="nucleotide sequence ID" value="XM_002181017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1M1"/>
    <dbReference type="PaxDb" id="2850-Phatr36534"/>
    <dbReference type="GeneID" id="7201842"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36534"/>
    <dbReference type="eggNOG" id="ENOG502SFMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638535_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1M1"/>
    <dbReference type="OMA" id="RADNEHI"/>
    <dbReference type="OrthoDB" id="408541at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF1">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="65"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="430" mass="48730" checksum="0CE39936362411A4" modified="2009-02-10" version="1">MADGEVGDNVAFGFCVSLTVNDIVADSLIVIVPVLYLFSQGRLVHSLSVRKCPRNLPSIECFPLQTLSPPFEDDAYRSICNFYRENYSRKRIVPSLPKFNCTTTDDVVCFMRCEGSDRIVAAVRLTHDSTHPEYVFIRSLCIEVSLRRQGLGSQLLQRAMDNFGAWSYYCLADPLLTSFYVAAGFTKADSSNDVPTSISQRYESIARRVQRKNRELHFFVRRPQPPPCAVILLQHVNENNRATATGWLVDDEAYQKATGTNLTTLQSQLTVARWTWSGRADNEHIQKMLSDLPSTPILLWAKKADKSYRMVASGEHFTPIYIILDGTWQEAQSMFRKIPSLWQLPRLSLSSSTRSSYVLRHDYTGWKQRFSSQGGEDLLCTAEVIAALLDESLNRESGNLIRNRLRYFQDNFPQVSARSFDADADSGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G233</accession>
    <name>B7G233_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181141.1">
        <property type="nucleotide sequence ID" value="XM_002181105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G233"/>
    <dbReference type="PaxDb" id="2850-Phatr46995"/>
    <dbReference type="GeneID" id="7202232"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46995"/>
    <dbReference type="eggNOG" id="ENOG502T46T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041745_0_0_1"/>
    <dbReference type="InParanoid" id="B7G233"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47232" checksum="AF960CC84A100344" modified="2009-02-10" version="1">MSDNNNTNHRCEPKNDHGESVASVASIYQLNGQRVRHTRINSTKYKDTFDDSRMVVVRYFLDRPGYDLHNATARLWFHPPTICSPEDVRYFLKNQGVSLEGLLIEIYLDTFESFMVLESCAANCVEWSFEGTSYQDPGILNIRLTDLIDATMENVSSTTRLVHPTKYGATKEQANTSPVGLFSFSMVQAMQTMQVMSKLIPDSVAESWTLTNGPYMFFLGGVVQFVVGIFQVLRGNIYGATAFLAFGGFLMADGAGIILRNHFSDAGSRAVELIGVPDPWGNFFRHAYICAFCCVLLKQTLVMNKLTTGLIAVVCTKLAASSFTGWSETFEWMEIALGWIVSVFAFYVFTVEVTNEVYHREVFPMYKWSERHSPEELFGATGRIGTLTSKATKLRQANYPTPLNIRWANTMHGSQQLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Q6</accession>
    <name>B7G2Q6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_28533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181423.1">
        <property type="nucleotide sequence ID" value="XM_002181387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Q6"/>
    <dbReference type="PaxDb" id="2850-Phatr28533"/>
    <dbReference type="GeneID" id="7201950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28533"/>
    <dbReference type="eggNOG" id="ENOG502S8RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178114_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Q6"/>
    <dbReference type="OMA" id="MTGICLW"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="76" mass="8107" checksum="73953BAF2FF5DF04" modified="2009-02-10" version="1">MSGIPGPVVTGTIAYLLLGVVAVGGIYGSRATGMLSKDNADIGNVVVSLACFSMWLFWLCAWLHQWHPLIAPIYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2V0</accession>
    <name>B7G2V0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_21441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181447.1">
        <property type="nucleotide sequence ID" value="XM_002181411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2V0"/>
    <dbReference type="STRING" id="556484.B7G2V0"/>
    <dbReference type="PaxDb" id="2850-Phatr21441"/>
    <dbReference type="GeneID" id="7202193"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21441"/>
    <dbReference type="eggNOG" id="KOG2532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G2V0"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852941" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="416" mass="44835" checksum="222FA6CC48050A74" modified="2009-02-10" version="1">MLTLLWVIAVLSALDRVAMSVAIIPMSAEFGYTDTFKGSISSFFSIGYGLMILPAGLIVANASPRTIMACGITVWSLATIATPWSTGMESLLPILLVRAMVGAAESVVLPTMQRLLSTWTDPEEKSVALATMFSGFQTGTVLAYLLSPAVVDLTGGWRGLFYTYGGVGLIALIPWLLFAQDAPSSKQSDLPTDQMGFQESTQVFRDAPFRGFFESPGVWAMLLAHCSKNWSLYNSLAWTPTFYSEQYEIGVRDSAFLSILPSIAAIIGGLLAGNVADAIIRKMEPSEERLSLIRKVFQSIGLYGPALALGVLALHIPEDPTIAQAFLTVSVGLSSFNAAGFEAGNQEKAGPKWAGLLYSVTSLPAVLVGTFGVYFTGQVLDWTQQDWTFVFGLNAFINVLGATAFLVLYDSKKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Y0</accession>
    <name>B7G2Y0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181463.1">
        <property type="nucleotide sequence ID" value="XM_002181427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Y0"/>
    <dbReference type="STRING" id="556484.B7G2Y0"/>
    <dbReference type="PaxDb" id="2850-Phatr47235"/>
    <dbReference type="GeneID" id="7201990"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47235"/>
    <dbReference type="eggNOG" id="KOG2925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106477_2_0_1"/>
    <dbReference type="InParanoid" id="B7G2Y0"/>
    <dbReference type="OMA" id="RFMITHI"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23571" checksum="5FC1409FA1FE16BE" modified="2009-02-10" version="1">MAGLGRRTHYRKHLTDSILHDFPEPLGDERVAKIVATRGSNQFDIVLSVEKSLPEEHSATTRPCHLAILPTKFRKLVWLKRNDFVIVQTATDAEGADRKNDSGGVRFMITHILYKEQIKHLQSNELWPGWDTEFTQDSIESSPQNEITTNEDCSSAGVRSFDEEDQASPIEDGIVYATGYDTDDDLFVNTNRLASLQVQDSSETESDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3I4</accession>
    <name>B7G3I4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181621.1">
        <property type="nucleotide sequence ID" value="XM_002181585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3I4"/>
    <dbReference type="PaxDb" id="2850-Phatr47483"/>
    <dbReference type="GeneID" id="7202590"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47483"/>
    <dbReference type="HOGENOM" id="CLU_502978_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3I4"/>
    <dbReference type="OrthoDB" id="49525at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="542" mass="58189" checksum="4A6956680BBA62BA" modified="2009-02-10" version="1">MASAFLPTNTTTTRNTLGVSPVGPSLCVPSLNESSIHTSKPPPPKPVWESETEDEEVKFSCVGGGRYTYGADFSDIESAGEDEGENCASEESDAEADAPDECTGVVTFVTAQPTISTQPSLLRPKAYSPSRSSPAASLSSSSTRNVSMVRHRQRDSSNERDSSSVGARGVPCTLFSSAMSEEDADDCEDEEVADGDDEDSDYDESEEDDVSSDDETDEPATSRIDFHAGGVSNANYCEPNGGVEEEPAGNGVTWDEPEEPENDLELASILGSSGDSSFDVEDESEFPTDFIVGVMQDRNIEATANVPKTKRVLSYTTLTALNVEAGHDDDSPKRQKAIDSPPQLPLLRLGPAATSMLPLLSVRSLREIREESPILSSSDEEELDERLRDELDKLGPERGENDGEAEMHHTRNGDSNTPVPLLTPPQSPSTIALEQGTSTTVCEWPSNMAVDSAMRTAAEMETMTVRVMSALSLTGLDDEGEESDSYDFNKVACYDDASLLPVTTLRESSSPETTTTATPSEAIDLNATTLTPLIRGIYVGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3M3</accession>
    <name>B7G3M3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CAAX prenyl protease</fullName>
            <ecNumber evidence="14">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_28833</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="14"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181639.1">
        <property type="nucleotide sequence ID" value="XM_002181603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3M3"/>
    <dbReference type="STRING" id="556484.B7G3M3"/>
    <dbReference type="PaxDb" id="2850-Phatr28833"/>
    <dbReference type="GeneID" id="7202611"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28833"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3M3"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="16">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="15">
        <location>
            <begin position="250"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC46853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="464" mass="52788" checksum="C5931DFEC07E9C6C" modified="2009-02-10" version="1">MDRWTSLPWTPFYTQQSANASTSAVSVDDQDSPLLAYWSLAATVAFTIVVYSFEGHLDARQKISYQQTSFPTELETTLQAKFRSAQTYGLDKINFGILAGTYDTAESVVFLLLGFLPYVWDWSCQLGQTYFGYHDEAAYETNISLIFLAIITLIGTVTQLPFELYSTFQIERKHGFNKQTLSLFFTDKIKSLLLTCLIGGPFVALLLYIIRVGGEYFYLYVWAFMFVFSAVMMTLVPVFIMPLFNKYEPLPDGDLKTRIYALADRLQYPLTKLFVMDGSKRSSHSNAFMFGFGNNKRIVLFDTLLTQVQEDEILAILGHELGHWKLGHTLSNFAVTQMYFGAAFYFFSLTYGSRSLYAAFGFDDVSRPVPTIVALLLFFQTLWAPVDKILSFILTITSRHNEFAADRFSVDLGMSQKLQSGLCKIHLENLGAMCPDPWYSTYHYSHPPLVERLGAMMALDRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3N0</accession>
    <name>B7G3N0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_37749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181819.1">
        <property type="nucleotide sequence ID" value="XM_002181783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3N0"/>
    <dbReference type="PaxDb" id="2850-Phatr37749"/>
    <dbReference type="GeneID" id="7202290"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37749"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576667_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3N0"/>
    <dbReference type="OMA" id="WGCETAR"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855689" description="Rubisco LSMT substrate-binding domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="5">
        <location>
            <begin position="469"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="579" mass="63793" checksum="15C219C944A30439" modified="2009-02-10" version="1">MWPTRTSILLCVVMLLSNARGEHRTAWQALRSRSVRPQPVPLLAPPPSAPFRFSSGAKSSTILCAKKPNTKAKPSVAPLQSLSRKNRIQSVLDWAQRADVQVSKEIALDSRVAEYGLGWYASTNIPTNQVLLSVPSNRALTVEIPGEGPDDRSVLDLVASSDSGSKTEVRALPWFVQMSLYIYKLDQVDADKEGVDMRPWLDSLPRSFDTVIHWSEANRQELQYDSMVTAVASQEQDWKRYYQSLLQAGASSSSLTWEQFLWGCEIARSRAFSGGFTGSAFNPGVYAFTLLLVTIYVGLGVGSLEQAANGAGVVFSASILKDFVLPKLFKKRRYVICPMIDMANHQSVKFAGQVSFEYFANAYSLATDQAIPSGDEVYISYGPRSNDQLLQYYGFVERNNPNDVYVMPPLREWDIEALERATDRKFAVGRLEKLNRAGLLGSATTVLSDKKYDETEVANANGGVVITRVLGLDPAILQALRALVSTEDEWNAAGQAVGSFAEEGSGGAANEAAARLAARTAVGMELQSKETTLQEDEALLQRMDTVKSMDASREEKLAVQFRIEKKKLLSETLDKLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3X6</accession>
    <name>B7G3X6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181515.1">
        <property type="nucleotide sequence ID" value="XM_002181479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3X6"/>
    <dbReference type="FunCoup" id="B7G3X6">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3X6"/>
    <dbReference type="PaxDb" id="2850-Phatr47306"/>
    <dbReference type="GeneID" id="7202481"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47306"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_4_0_1"/>
    <dbReference type="InParanoid" id="B7G3X6"/>
    <dbReference type="OMA" id="FIVTESK"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855377" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="193" mass="21560" checksum="E05A36F457837D09" modified="2009-02-10" version="1">MTMGMRSFFSFLAFATTAAAIQELDEASFDQLMGSGKNGMIKFFQPWCGHCTRMKPDWDKLAEEAHSSVFIADVNCSDQAELCEKNDVAGYPTIKVYKDGVDEKYNGARGFDDLMDYVDANLASKCDVSKLEETCGEKAVKYANKWKDREAADVTKEFSRLEGMAGKSMTMELKAWLRERMAILKQLTASASS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3Y9</accession>
    <name>LIPA2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName>Lipoyl synthase 2, mitochondrial</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase 2</fullName>
            <shortName evidence="1">LS 2</shortName>
            <shortName evidence="1">Lip-syn 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">PHATRDRAFT_28652</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181691.1">
        <property type="nucleotide sequence ID" value="XM_002181655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3Y9"/>
    <dbReference type="SMR" id="B7G3Y9"/>
    <dbReference type="FunCoup" id="B7G3Y9">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3Y9"/>
    <dbReference type="PaxDb" id="2850-Phatr28652"/>
    <dbReference type="EnsemblProtists" id="Phatr3_J28652.t1">
        <property type="protein sequence ID" value="Phatr3_J28652.p1"/>
        <property type="gene ID" value="Phatr3_J28652"/>
    </dbReference>
    <dbReference type="GeneID" id="7202486"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28652"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_1"/>
    <dbReference type="InParanoid" id="B7G3Y9"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000398244" description="Lipoyl synthase 2, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="58"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="314" mass="34862" checksum="70E379E29A535340" modified="2009-02-10" version="1">MPKGRPSWFKVPAPSQGTQSTYSTASYSRYAQVKDSLQKLDLHTVCEEAQCPNIGECWNGGTGTIMLLGDTCTRGCMFCAVNTDSKPPPPDPFEPFKTAEAVVAWGVDYIVLTSVDRDDIADGGAQHFAQTVQLLKQNKPNLLVECLVSDFQGMLDSVETLALSGLDVYAHNVETVERLQPFVRDARANYQQSLSTLQHAKVVKPELYTKTSIMLGLGETEEEVTQTMTDLRAIGVDVVTFGQYLRPTEHHLSVVEYVTPEKFDHYRQVGENMGFKYVASGPMVRSSYKAGEFYLEHMIKKERTEAAIDIGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G418</accession>
    <name>B7G418_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181838.1">
        <property type="nucleotide sequence ID" value="XM_002181802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G418"/>
    <dbReference type="PaxDb" id="2850-Phatr47545"/>
    <dbReference type="GeneID" id="7202765"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47545"/>
    <dbReference type="HOGENOM" id="CLU_814997_0_0_1"/>
    <dbReference type="InParanoid" id="B7G418"/>
    <dbReference type="OrthoDB" id="55557at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34867" checksum="32B54E70F9DF8107" modified="2009-02-10" version="1">MSTPDVPPRTPAQARHDDEAFLVQGFATILHYHNDDIIAIRRIERDVDRDNIRTDFTPYEKKVLRISNYRNYHVGLAAGAFTMAVLSGITLWRTGTVRSVPLQKLVTNTKTQAYTQFDGVARRTQTPHHQQHHHNRNVPPKQPWRSEELDSSEASSPEIITSLHNMVFGAIAIVVTVVTANATLDRKAYVRGLSTVPLLPGSSQFCQRVCPALQEHYDRTIKSSVKLPQGHDAQTLWNDPVTDELESIVIMLHNCRQRQAFEADLRQSQTSPPPSWHKPVHIPPPGVPSNYLGISVGDAEQLTTDAEEGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G430</accession>
    <name>B7G430_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thymidylate synthase</fullName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_2087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181844.1">
        <property type="nucleotide sequence ID" value="XM_002181808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G430"/>
    <dbReference type="STRING" id="556484.B7G430"/>
    <dbReference type="PaxDb" id="2850-Phatr2087"/>
    <dbReference type="GeneID" id="7202626"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2087"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613202_0_0_1"/>
    <dbReference type="InParanoid" id="B7G430"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000008">
        <property type="entry name" value="thymidylate synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="217" mass="24602" checksum="271EF30F4C640C20" modified="2009-02-10" version="1" fragment="single">NAEERQYLDLCRHILDHGVHRGDRTGTGTLSQFGTQMRFSLRDGTLPLLTTKRVFWRGVAEELLWFVAGNTNANDLAAKDIRIWDGNGSPDFLDSWGLGHREVGDLGPVYGFQWRHFGATYGTIHDDYTGKGVDQLAECIDKIKNNPEDRRIILSAWNPADLELMALPPCHMFRQFYVDTEKNELSCQMYQRSADMGLGVPFNIASYALLTHMIAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4E4</accession>
    <name>B7G4E4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_37916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182059.1">
        <property type="nucleotide sequence ID" value="XM_002182023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4E4"/>
    <dbReference type="STRING" id="556484.B7G4E4"/>
    <dbReference type="PaxDb" id="2850-Phatr37916"/>
    <dbReference type="GeneID" id="7202843"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37916"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292648_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4E4"/>
    <dbReference type="OMA" id="FSPKNEM"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="784"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="922"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1041" mass="112731" checksum="96389E7ABFA5EE90" modified="2009-02-10" version="1">MKRRRISHAIPLALSVCLRSRLIDSFLALPSKLHSNRLVFDSPSSTKTTCKRDFRIFGDLTGKLEDDQDAQELTTTRHSSTHQSRRKAMQALGLASLAIPMAASAGIAELDKSTGALFSPKSEMLSGGSAAARGIPVSGSRRQQLQPGQALQTVYETRFIVYLARFLLNFDPSAHAWWLQQGFADSWEPRSGSDEAFADNTLAEFAESVEVGLADYFVGPYGSYSSLSAAKAGISAARPAPSAQPQQEENYLKELLFGRPKLSDEKTPKEKVDSAKKGILNLYTLLKARYTSVAAKRHLAILFSFISSPRLQPSNEILALLGESDNATISEIRIVKPTHWPVNEADSRTSSRRGGGYSIEEPPIVTIDEPPALGDSYVPAELRPVLKPTSRVLRISVIDGGEGYTSAPQVTVVQSGYLRLCQATAIIDRSGRVESVILLDPGWGYGGRKQAPPKVKIEPPRLKSKGESGQRAKAVAELEYEIVGAKVVRGGNGYVKTEVPQITITPPDGNPDWFLAVQEQPEMRMKKPAEIEPLRLEVAEMKFSDGSVAYSIDRMPESKGVDNALLDRLQRDPLEMLPPSIRPERYKYGIYAIPSLARIPQSVPNLSPRYRACDPVFGGVGRVPVTKGAVALKASEYARLALSGAVCTVLVRTALNPLELIKTKQQLQNDNELLSFARARALRKGISPDHQDAHEHMLSSNKAEINATAAVAPQETDGQIKLGTLDLISSLIELRGPLALFQSADITFLASLVFGSLGFGATELFRRSFTAFFIAGSGTDEIGLDVVALLAAASLATVVTAAAAAPFEVLRVRSMGLIESVGWTKVLEDFIAEKSRPRQKTSNSFGLNRKQHGGHQEFELRNLKARDILPLWAGFAPTVSRELPFAVVKFLTFDFITGTVITFLNTQSSDGALPIQVGTGPIGLIVSALAGAVAGIAGAVVSHPADLILTKTSASGNRNGTETSASVEEPDWRDVVRELIAQPGGIANLYVGFPARATFFFLVIGLQFFLYDYFKTLLNVGSDDLSLVLDVFYAVRAGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4R1</accession>
    <name>B7G4R1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182118.1">
        <property type="nucleotide sequence ID" value="XM_002182082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4R1"/>
    <dbReference type="PaxDb" id="2850-Phatr47742"/>
    <dbReference type="GeneID" id="7202913"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47742"/>
    <dbReference type="eggNOG" id="ENOG502SVPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149787_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4R1"/>
    <dbReference type="OMA" id="VRAHANC"/>
    <dbReference type="OrthoDB" id="10444292at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15381" checksum="0E305F4C82B3DA8A" modified="2009-02-10" version="1">MSVDLSSSPAALMAFAAWIAFHMMVIMTYRATLVITGKKVNTFGPSRSDSQSSFIGRVGSSHANCLENFPLFLTVVMVNTVTSGPDISELAWHYVYARVAQSLAHWYSFSELTVMVRLTNFLVSWGLLVTIGYRTMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Y2</accession>
    <name>B7G4Y2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182317.1">
        <property type="nucleotide sequence ID" value="XM_002182281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Y2"/>
    <dbReference type="PaxDb" id="2850-Phatr47798"/>
    <dbReference type="GeneID" id="7203042"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47798"/>
    <dbReference type="HOGENOM" id="CLU_1550529_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Y2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="25420" checksum="4E53465F1807E0BC" modified="2009-02-10" version="1">MEFFNYTMDEHFDGAPVPVYLPTCGNCLSTTGDSPDALPTADEMWRQNHAQALQELHIAYLRFADEWYHQAVAKLPQIWKKTNLWGDLETFTELHKNGQALVDFDEQDYENRGRIAKHEREYLWRTFRDYEAFDAAKIYSLFTGSKYVPLQARWMDLHDVEAWRRDFLTPECRGGSRGADLAPNVKCWIYWMRRTSGGHPPLYKECFKIADSKDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5A7</accession>
    <name>B7G5A7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182213.1">
        <property type="nucleotide sequence ID" value="XM_002182177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5A7"/>
    <dbReference type="PaxDb" id="2850-Phatr47898"/>
    <dbReference type="GeneID" id="7203164"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47898"/>
    <dbReference type="HOGENOM" id="CLU_1535454_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5A7"/>
    <dbReference type="OrthoDB" id="10554205at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="175" mass="20200" checksum="D51B6F116E0E4219" modified="2009-02-10" version="1">MNRLFCYTIGLQVPTLASRRQLVMQERLSFKTEQKDEILAICDSPVYGNFPKVKSLSTMSADDDTASTVSSFDDSLSGYSVTFADEIVTAVFVRPATTREEKRELFYSDIDYRRFRYESYCNREIKDTVVKFAPSVVSNIHVYPCAEEKELLFYSATDLQRFLDEFVSHLRETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5A9</accession>
    <name>B7G5A9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182383.1">
        <property type="nucleotide sequence ID" value="XM_002182347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5A9"/>
    <dbReference type="PaxDb" id="2850-Phatr47900"/>
    <dbReference type="GeneID" id="7203166"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47900"/>
    <dbReference type="eggNOG" id="ENOG502TAQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1392595_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5A9"/>
    <dbReference type="OrthoDB" id="47934at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="196" mass="22718" checksum="9CC932AC6E273F00" modified="2009-02-10" version="1">MGGRRRERITRCISVLQTGQHDVATKPIDPAVEERHLILFQNSPHYESSSSLARSDSTTTTDHILDRIQFKNDRKTVSFASIEIRNYSIVFGDHPYCNDGLPLSLGWDFDGINLLSLDTYEATRAPRRSRRELRMSCEERRQLLSEDGVSEGEIRRAQRKMHRARSCSAKLCEKMTESFFRDEPKLIQSQPNMRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6M7</accession>
    <name>B7G6M7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182885.1">
        <property type="nucleotide sequence ID" value="XM_002182849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6M7"/>
    <dbReference type="PaxDb" id="2850-Phatr48292"/>
    <dbReference type="GeneID" id="7203724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48292"/>
    <dbReference type="HOGENOM" id="CLU_677011_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6M7"/>
    <dbReference type="OrthoDB" id="48335at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="260"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="407" mass="45792" checksum="EA2CE6216C9BDCB1" modified="2009-02-10" version="1">MAEEQTYLRVRRRRNAGTALTMIRLEGIEDSRKRDRTDDEAIQDLTASLSLQHDEAQPRKLRKRSTVWRRLDSTSTESEEIDTKAKRRSFRVIDAILSDDEFTDLPLAAELQRHKRRRLKLVETTEDAPSLLKAQTSAPSVAKSLGYRVLDPLSRLVDDSLQSVHRGETTIQQHMNLILTDSRLMDQSWLEWCNDKYGNLLHSCAVWNEVQHATDLLSRNLDNMADTLDAEGRTPYQVAQLSGNTQMCAVLEAFGADHGNYVYDIYCMDDEPSLNTDAEAPDALIEEPIACSLFGGVGYWNEKGKLVLEIPAGIKGSATAQSNQDEEDSNDEYWMGNDYPDEDAWGESDSDSNDPCLPDVTYRRRIVCFGEDQNSSQSAHAGSDNGEDGFDAAYGIALQNDIDYEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G749</accession>
    <name>B7G749_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_38893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182843.1">
        <property type="nucleotide sequence ID" value="XM_002182807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G749"/>
    <dbReference type="STRING" id="556484.B7G749"/>
    <dbReference type="PaxDb" id="2850-Phatr38893"/>
    <dbReference type="GeneID" id="7203679"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38893"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_1_2_1"/>
    <dbReference type="InParanoid" id="B7G749"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="20392" checksum="A31A66F5F88488DA" modified="2009-02-10" version="1">MPDFQYPEFYSFPPFFTIQPVLATREKQMALWRELILRYHTEKKIKTLVVHDCPLWKNDNIKRRLQPGEIQEVLDDFCRHGHGEWQDANKTTCRILWRTPEQLATDIHQWAEKNGYVGSVCTVYELHSGEDVNGMSFQGADEELLRRALSILEDRGKCTIFRGETSEEDGIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7F1</accession>
    <name>B7G7F1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183263.1">
        <property type="nucleotide sequence ID" value="XM_002183227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7F1"/>
    <dbReference type="FunCoup" id="B7G7F1">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7F1"/>
    <dbReference type="PaxDb" id="2850-Phatr48699"/>
    <dbReference type="GeneID" id="7194684"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48699"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7F1"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24701" checksum="5F5437765B5AF6FA" modified="2009-02-10" version="1">MGRRPARCYRYQKNKPYIKSRYCRGVPESKIRIFDVGAKKAPVDQFPFVAHLVCDEKQQISSEALEACRVAINKHLSKNIGKDAFHIRIRAHPFHVLRANKMLSCAGADRLSSGMRHSYGKPIGVAARVDIGQILISVRSKDTHEAHVIEAIRRGKFKFAGRQKILKSLKWGFTSYPREEYVRMRRCGELSADGNIVKVHNRRGPLEKSALYKAGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7K8</accession>
    <name>B7G7K8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_15229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183036.1">
        <property type="nucleotide sequence ID" value="XM_002183000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7K8"/>
    <dbReference type="STRING" id="556484.B7G7K8"/>
    <dbReference type="PaxDb" id="2850-Phatr15229"/>
    <dbReference type="GeneID" id="7194709"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15229"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299670_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7K8"/>
    <dbReference type="OrthoDB" id="39248at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="54" mass="5978" checksum="FA5A3F33FAC13344" modified="2009-02-10" version="1" fragment="single">MRKFFRELASGVRYCHANGIAHRDLKPENLLVHNSRTGSCTLKIADFGLSAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Y5</accession>
    <name>B7G7Y5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183225.1">
        <property type="nucleotide sequence ID" value="XM_002183189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Y5"/>
    <dbReference type="PaxDb" id="2850-Phatr39150"/>
    <dbReference type="GeneID" id="7194888"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39150"/>
    <dbReference type="HOGENOM" id="CLU_1104554_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7Y5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34138" checksum="D313F4FB54580B58" modified="2009-02-10" version="1">MCKYSIIQITSKNRRKPILRLVLFTLLPASCIDFGRVDAFLVVGQVPVVSMVRTPSSAWDFSNFARQERRSLDYEQLPTLHVASNESKNDFNVTTTKERAAKMDNFVTNEDERKRDKVDTRIKRQAIDRVWIADRSLWTADVLGMAVACQLLGLVDAVTAQDFVTNGGWFQPITVQSSTTTLPTLVQRFSVNTVVWTMAATVLPLLPTAASGTRPEYYGEMMLQESLWNTRKIFVLVLVVFVLLRVTLDVGVVAFLMVTGTAHDLPSELQLRMLETLRECYFVGLAMATTRSAMHELYSTRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Y7</accession>
    <name>FEN1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
            <shortName evidence="1">FEN-1</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FEN1</name>
        <name type="ORF">PHATRDRAFT_48638</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183226.1">
        <property type="nucleotide sequence ID" value="XM_002183190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Y7"/>
    <dbReference type="SMR" id="B7G7Y7"/>
    <dbReference type="FunCoup" id="B7G7Y7">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7Y7"/>
    <dbReference type="PaxDb" id="2850-Phatr48638"/>
    <dbReference type="EnsemblProtists" id="Phatr3_J48638.t1">
        <property type="protein sequence ID" value="Phatr3_J48638.p1"/>
        <property type="gene ID" value="Phatr3_J48638"/>
    </dbReference>
    <dbReference type="GeneID" id="7194839"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48638"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="InParanoid" id="B7G7Y7"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403552" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="127"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="1">
        <location>
            <begin position="379"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="421" mass="46668" checksum="B08A9CCD0A85275F" modified="2009-02-10" version="1">MGIKGLAKLLSDEAPDCIREVELKSLHGRKIAIDASMAIYQFLIAVRSGGPNQQATMLTNAEGETTSHIQGMFNRTIRYMTEGIRPVFVFDGKPPDVKSHELIKRREKREKAQAALAVASEEGNVEEQDKQSKRLVRAGTKENEDCRKLLTLMGVPVVTAPCEAEAQAAALCKAGLVYATGTEDMDALTFATPILVRKLTFANASKSMVQTMNYNKVIEGLAISHDQFVDLCIMLGCDYCDTIRGVGPKTALKLIREHGNIEKVIETIDRKKFVVPESWVPNEKKLDAQSDDDDEEGVESPSKEENNGIVDTEELIPAYVQARKLFNEHEVLNDIELKWKPCQAEDLQKFLVDDMGFNVDRVKNNIEKLQAAYKANSKPQTRMDSFFAVKANPNAAKSAAKRKADAAKAKAAVSKKKTKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G822</accession>
    <name>B7G822_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_15212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183119.1">
        <property type="nucleotide sequence ID" value="XM_002183083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G822"/>
    <dbReference type="PaxDb" id="2850-Phatr15212"/>
    <dbReference type="GeneID" id="7194858"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15212"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G822"/>
    <dbReference type="OrthoDB" id="196083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="255"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="475" mass="51889" checksum="3253540C34372F4A" modified="2009-02-10" version="1" fragment="single">MFFLSCEGHNGAGKSTLSNLISCEFRPTSGDVKVFGHSVTNETCAVRNLVGICRQDDYLYPNLTAKEHLELYAGLRGVPLKNIPSVVQEWLESVDLQSVQDHYSASYSGGMKRRLSLALATIGGRPLIILDEPTTGMDPVSRRFVWRHIDSVKEGRVILLTTHAMEEADLLADTVAIMRKGKFAAVGTPLELKAEHGSALQFSVLVEPELVSTTESSIRDRFAQYKEFFTLTAGSAGNLSANIRRVSKTDGEEGVDVDTLTEFVACFACTDELDLHVPKGQVIGLLGKNGAGKTTALKILSTAHDATDGVALVAGYNVNAEQRRVFEHLGNCPQFDVVWDRYTVEHHLVFFARLKGLPRKEVRDIAMRVANAVGLGAPEVFHRHVGQLSGGMRRRLSIAISLVGAPDVLLLDEPSTGLDPSTRNSIWGLIHSFATPERSIIITTHMMIEADTLCNRIAIMKKGKLAVVGTQQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G873</accession>
    <name>B7G873_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183422.1">
        <property type="nucleotide sequence ID" value="XM_002183386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G873"/>
    <dbReference type="PaxDb" id="2850-Phatr48736"/>
    <dbReference type="GeneID" id="7194999"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48736"/>
    <dbReference type="HOGENOM" id="CLU_1100300_0_0_1"/>
    <dbReference type="InParanoid" id="B7G873"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="27955" checksum="FB74DCF850605070" modified="2009-02-10" version="1">MLHSRRPLSSADGTLRWSNDENSVAQKPIVGMDASSKTPAPSKARRAFGDISNRKKAGGGKVIALAKLSTVASQTNGGKVQSVPETPLQKRVIKDSPATKRRVDFALPSSVHKNLQLTQPKALTDSHDLRGADFEYSSTDDIEHPAGRLWKDEQALLDDDSTTASMDELLNDATSVWTTFKDQERVLLQRAKEEQEHALLFLDQQFQDMLHESVKLSSPNGSLYDAAELLDMKIVESDDDFSCSQTRVLNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G894</accession>
    <name>B7G894_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_48755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183432.1">
        <property type="nucleotide sequence ID" value="XM_002183396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G894"/>
    <dbReference type="STRING" id="556484.B7G894"/>
    <dbReference type="PaxDb" id="2850-Phatr48755"/>
    <dbReference type="GeneID" id="7195034"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48755"/>
    <dbReference type="eggNOG" id="KOG2557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465784_0_0_1"/>
    <dbReference type="InParanoid" id="B7G894"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="330"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="586" mass="64165" checksum="A7F777285B39047F" modified="2009-02-10" version="1">MGNSDSSSRSPASLADRDIEDLGRRFPFGDTELQALYAAYGAMAYPGSAVHRVSFWSDWARAIRRPGRDAAEATVATDTALLLRVCETKILTPDLGTRLYRAAFWVPGDVLWYGGTGQSQNPKSLGEQVNAVPLAKDGSPEPTTSDEYTRKARLERTFEGLTLSSRKGSGPAVKVLFDALALDPHAPATLTTVPTRIRAFDFVTAGYRLAMATAFLAAAAHDNDDADDMAGFLPEADSSGRDAVALRALAQSLTERARMREARPGMSIESPHEDHTDDHVELEDVYDWIDAVAPLFASILPTFWHQILFPHQAYPPSRTAFSFPRVPCDSVFFESTSSPTLFTLGCLSKSLTGVYYRLYTSASDGLSFNRLQNALLGYSGPTLLLIRTTGGAILGAFTASAWKESRDFYGNTDCFLFSAAPVTAVYRPTGTGRNFMYCNSFARSRGYDQQAHGIGFGGTVDEPRLFLSESFDACRAGAQDCTFANGSLLPRTSSGAPQTNFELDAVEVWGVGGDDVVDAALGQRQKARALREEGIRRARKVDKAQFLDDFRSGLMDSKAFQHRQQMRGRADVDCEERATKQYEYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8J1</accession>
    <name>B7G8J1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">digalactosyldiacylglycerol synthase</fullName>
            <ecNumber evidence="9">2.4.1.241</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_2215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17615"/>
            <dbReference type="ChEBI" id="CHEBI:28396"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.241"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.241" evidence="9"/>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183353.1">
        <property type="nucleotide sequence ID" value="XM_002183317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8J1"/>
    <dbReference type="STRING" id="556484.B7G8J1"/>
    <dbReference type="PaxDb" id="2850-Phatr2215"/>
    <dbReference type="GeneID" id="7195131"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2215"/>
    <dbReference type="eggNOG" id="ENOG502QQ73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336665_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8J1"/>
    <dbReference type="OrthoDB" id="44480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046481">
        <property type="term" value="F:digalactosyldiacylglycerol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01635">
        <property type="entry name" value="Glycosyltransferase_GTB-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044525">
        <property type="entry name" value="DGDG1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132:SF1">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC45053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="415" mass="46215" checksum="C24E92504F87AF7B" modified="2009-02-10" version="1" fragment="single">VFIVTTAALPWMTGTAVNPLLRAAYLTLRNAARCPHQDCDGTNNSSNAITNKTNTNTTVTLVIPWLESAADRVLLYGDAWKHATTAVQETFIREWLVTRASLTSQQAHSVVIVFYPARYHHGLSSIFAMGDFCERLTVPDDAVCLLEEPEHINCYRAPGKTSWRKKFAHVVGIIHTNYKAYASHHYSGLLTGPLVGVLSSWCVRAYCDKVIKLSPVLQTYAAEKETVCNVHGIRDEFLHTPAPTGPKIYFLGKLLWAKGLDKMLRLQYAYRKATGSYFAMDVFGSGPEEKEIRKAFLGEALEDDDFLGRQDHGTISTDYKIMVNPSITEVLCTSTAEAVAMSKFVILPTHPSNVFFEQFPNCLFYETPADFCRVLQHATSHNPEPLTPECRDVLSWSAATTRLLEAGQVSERDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8K8</accession>
    <name>B7G8K8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183490.1">
        <property type="nucleotide sequence ID" value="XM_002183454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8K8"/>
    <dbReference type="PaxDb" id="2850-Phatr39417"/>
    <dbReference type="GeneID" id="7195142"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39417"/>
    <dbReference type="eggNOG" id="ENOG502SUSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609017_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8K8"/>
    <dbReference type="OrthoDB" id="48529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="37540" checksum="4EF98BF3A785659E" modified="2009-02-10" version="1">MANNLGYLARGLGMAWWLEREFHVNATIVLRHQNHDKWIRAYQDVTRCFPNVRDWSFTAGNTDAVTRELQSSPPLIVTGSVVPQRRVVYALEPYNETLQSFLTLYNENHTRMAEGNGHVSIPFLTTKAMSCNDHILDKYYEDFRRIYRFDESCCIDRPDEDESVYHFRNFIGEMPKNTKRLGFEELAPDAVANQLFAHLHAGDKVAIASRFGEDFRTQMLVRAFARRGILARVLEPRSGVADFCFLLHAQKELVGTAQSTYFMWAGILGNARRVRAYSVRTPEGNNLVHNSNWTHPDLQRRFQFELYSVNSSATDLLNPNATLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L0</accession>
    <name>B7G8L0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_39419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183360.1">
        <property type="nucleotide sequence ID" value="XM_002183324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L0"/>
    <dbReference type="STRING" id="556484.B7G8L0"/>
    <dbReference type="PaxDb" id="2850-Phatr39419"/>
    <dbReference type="GeneID" id="7194938"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39419"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G8L0"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="4">
        <location>
            <begin position="204"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="40163" checksum="40809EEE566CF19A" modified="2009-02-10" version="1">MNQAQLQQKQERLRQLQEEERQLRLQLQVQEHAATYQVELAWPARIVDSNGNAPRTNNELIQHRLLESGVLYEVPVRVGATVESTNAFIQDLEKTGCFNSVRVEVGQGVSDEDASTRVQKQLKITLDEKRWYRVNAGAGVKTDGWLRPETAVNDGFLPTAEIDHSLASPEYTPDLYYGVEWSLLSRDLVPRRQSKMPYAMDASPEVVSQAGPSLKHSILAEFRSNGELLDHPYSPTGGVEMHGSAEVAVPPGSVGFVRCNGGFGIHMPLLQSLSVHSIFNAGYLKALSFGGLCRPPTLSDRYYVGGPLRFRGFVPAGIGPRTKHGGSSTPGGDAVGGDFFYTATAMASITPTSGIQSVDSLRLRVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8N5</accession>
    <name>B7G8N5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183503.1">
        <property type="nucleotide sequence ID" value="XM_002183467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8N5"/>
    <dbReference type="PaxDb" id="2850-Phatr48869"/>
    <dbReference type="GeneID" id="7195155"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48869"/>
    <dbReference type="HOGENOM" id="CLU_408552_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8N5"/>
    <dbReference type="OrthoDB" id="49406at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="673" mass="74871" checksum="E18E5F771C29FF4D" modified="2009-02-10" version="1">MSDDDEESGRADISTFPRFDDKLAPPRPFLVPSFDGEIVEILPSEKANRKIRFDETVHICEIENRFAYGDYPADDEEGSYEIEIVDENDDEADFYLEIVDGEVYYVFETEDDISVEDDSYETEDEDDAESNDGPIQSLQLAIANMQIPDFDGDVCVMADNVEIEKVGEDDNGYSEDSLGESQHPTIEEINIKDTDEVIELEENNGEYEEKVASKIVSLSIHTKEEPLSSLDSSIRIPTAATPDINLKTDTLEARVQDEDLMNNTDAIEIFIGKKGPIAAAQLEEAGQSISGSDHEKANENNDTPISPQAGVAPGATASPLSSIRCPVLATPNHTPKRSIGADAPDSPVKGIPPASPVKSILRACPESPRKAPKKKPKAREVSTKREKTFTKTYVRAETFDGEHRVYSWAKPDWTQETKLKSTGLGDRIRNGGNLANPITFPKKKPANADLVEEEYEQVNKEELIRRIKDGHSAPGVKLPRYLRGQSKLKISVHGARIRDGGDLVKPVTMATTTKKSYEFQKPEWTQKKLNETEIGKKVKSGADMQQPVTMATTQKKYSWEKPSWTKQRSLRSLGSSDGEEAASEIEKKIYTWEKPRWAKEKVLGTTGKIRKIQDGGDIVKPITFPEGKGDGINQEVRPELVLRPSKKGIHARHGEKLERPITVLPDLAKCKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Y5</accession>
    <name>B7G8Y5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183548.1">
        <property type="nucleotide sequence ID" value="XM_002183512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8Y5"/>
    <dbReference type="PaxDb" id="2850-Phatr48943"/>
    <dbReference type="GeneID" id="7195361"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48943"/>
    <dbReference type="HOGENOM" id="CLU_1317691_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8Y5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="209" mass="23069" checksum="8BC0ECC0C4AB7BB2" modified="2009-02-10" version="1">MNPSSPDKSFVRRENADNMYGYEHHTPTTPCRKVERERHEMMPRLPQRSSDIGFASEEFSGTNCPPMSPDRVARKQRSISRRGGACYATLLQSAVQASMSSFDPTGSDGETDALGTSFVSLGSMFLQDGPASPRKRVRRLQDKKDNEDAIEYASDLLGSLCVGPVDDASEETKASSSIGERKPPVRRVSRRTSYDSRVSDGTDFEFDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G948</accession>
    <name>B7G948_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183707.1">
        <property type="nucleotide sequence ID" value="XM_002183671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G948"/>
    <dbReference type="PaxDb" id="2850-Phatr48992"/>
    <dbReference type="GeneID" id="7195391"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48992"/>
    <dbReference type="eggNOG" id="ENOG502SZHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607611_0_0_1"/>
    <dbReference type="InParanoid" id="B7G948"/>
    <dbReference type="OrthoDB" id="44012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853097" evidence="3">
        <location>
            <begin position="28"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="451" mass="50854" checksum="45E9CED1DA89DBD2" modified="2009-02-10" version="1">MFPSTVSATTELLWRTLVVLLAHQSATRVFTTAYKDDSYYPKGVANPNTKNAMYWRDARNVLQDISQFQSLSIKYHSCAWSGVAVSNQGGSGDKNGADNLCQTIDYGEGDDENNAYDWWYLGSTVCNRANAAFSLYGTLAGEEEKGCRKSSYINSFFTNQGLGPFMQAMTNAGVSYFQTDDNTNSLSSYCTIIEGATDDNYSGGDDSYEKYAYGNHNEGYFDNFYSQSLACNRGRFVQQNFQGAFCNAEQMTKIVDSMNQVNSALNSLDCVQIYNADSNENSNGDNNDEDEDYDGALQLLQYSEACSLRDPSGACPDPFGKLQKYSNTIERISRALDMTSYRRKMRRNISLLMIVMGVAFFLLAFRVFLRRVLKRFPALRKRLRGGSFLRSMKRRSRRKSEGDGIHKAIDSDRNSRKKSSRRQRDPRPAQDYEGDNRNDTSSSQHELPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9N4</accession>
    <name>B7G9N4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183805.1">
        <property type="nucleotide sequence ID" value="XM_002183769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9N4"/>
    <dbReference type="PaxDb" id="2850-Phatr49150"/>
    <dbReference type="GeneID" id="7195650"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49150"/>
    <dbReference type="eggNOG" id="ENOG502R34C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025479_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9N4"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="349"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="650" mass="72709" checksum="71BF20BF184953FE" modified="2009-02-10" version="1">MRLTPRDSGDSGATKKANRSCLYSGSMKALSRAFLTHLLACWIGYQLGFSVQTSVTKTSTEPFVNREGASKNGVSWMNARHMEQQMQHPQAVQACPKPTPCSSQPESASFDHDNFIPAEYRSFVAGMSRVDRTDFASQYDTGIPLDIKAKANQRLEKHQQALLLHMSPLSVPDFISYRQTNSSTATRALPLLSAEDATRHCHVVQVVHVRSTLPPFQRHCVAIVPQWDDDATVHKFMRVPDDSHFASVRTGHRNGAQNTGVLNESLPARYVSRTHTEGGIYTSVPGPGRRYWDELAQYHATLPTFLKQLGPIADQAARNQTIVVMTCNQGQSELLVNFVCSCTRRGLPISHVLVFATDTETYKLAKSLGLRAWDVTSLPGAFGVRSFPTKAADAYGDLTFAALMMAKVYCVHVVLLLGYNVLFQDVDVIWYQDPVPYFETHWTTMDVIMQDDGARTKRFAPYTGNSGFYFVRNNERSLYTWAALARMGDTVAVMKSHQAVLNTVLEQQASWRGLKVKTLGRFTPEGLLFPCGFQYQKRFGVFERAGDDGKVAPIVMHMSWTYNKSDKLKYMKQMGDWYARDVCILDEDIGNAKAGEVKLEQIIATASAEAAIDHCCEVDPIVTCYYQDKPSKIPCKDSPKKEPNGIPFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA91</accession>
    <name>B7GA91_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_49335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183905.1">
        <property type="nucleotide sequence ID" value="XM_002183869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA91"/>
    <dbReference type="PaxDb" id="2850-Phatr49335"/>
    <dbReference type="GeneID" id="7195597"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49335"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324279_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA91"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="428"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="769"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="891" mass="98624" checksum="8261BDEB988F3347" modified="2009-02-10" version="1">MANGGTIAGDTKWKILLFGAIPDTQVLLEKLHEIHDGPAGPFHVAFVTGFVENVRVLEKANAPIPVYLYPFAQYRNAGIDCDWPSNSARPSDPLSLSSQLSTPETTHGKPPCATRLYDALRIANNFFILGDCSRTSSALLYRLPLSAGSGAASCGSPICETSQGSPHSTSPTSPKTPLIVLVCPGIVSNIPLIMNQLALTTTNHGCDLFFSTQAAVGVQDVLDEDPKDITLDYTTTVSRLVQAYQPRYHVIAANKYCSSHSFSYSMDDVTQRLSARNSRVGRFLTLAPCRDGPSRGSDKFVHALSLQPSFTMTSLDWQRERPGFVLANPFQHLALEASTEAEESDNYVSGTTPRRLFPPTSPLTIREYDDDPRTGRNGFHNDGAQLQSQSQFFREYRVSIDESNRVHVSSHTFYSNLSSISFWQHLSQTPIRFATELFMPVGYPYSVREGYLSYQIYDSIQGLSSYLRAVLCSAQVLQAAGVGDANATAIMAALTWALKDGLGMIGGLIFSYGVASHLDAYVKEFRLFADVINDVGMLLDMLAPYVPRADLIWISSAATLCKVMCGIAAGATKSSITQHFALQGNMADLNAKEATQETLVNLIGMVCGVTLARYLSQLEAGNEEGDTDRIGYRSWIPCISHDSIQWMVFTILTLLHIWSNWKGVSLLRLETLNRERTKVVLCAAGLWRALVPDCEALRSEKYAELGLLRQEMLLETLQKCIENIPRPNDMRESLASSTWDLLMPTRLVLHARLKDMIAIDWTATKDFVNEKYVVVLSDRGRALVCLLTGAAPMDELKAFMHGLLILKCLDSIGRKLNLGDVGQRSELVRQTQQQINMLFNPSWASQSAQSENTSEPLSFSKELRAKGWDVDGRLYLGFPRRRSQWMPEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAB1</accession>
    <name>B7GAB1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184043.1">
        <property type="nucleotide sequence ID" value="XM_002184007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAB1"/>
    <dbReference type="PaxDb" id="2850-Phatr40038"/>
    <dbReference type="GeneID" id="7195507"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40038"/>
    <dbReference type="eggNOG" id="ENOG502SCEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112241_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAB1"/>
    <dbReference type="OrthoDB" id="198528at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="214" mass="22521" checksum="8FFDB27A8EE084ED" modified="2009-02-10" version="1">MTSPNGMTWTSCTSPVASFWKSVTYSDELFVAVAQDAVGETDCVMTSANGKNWKSGTAAANYAWVSVTYGNNMFVAVSETGYDQVMTSPNGENWTSRSAAVAKDWRSVTYSDGKFVAVAGSDGNNDVMTSTDGETLMIVSSGVDALWYSVTFGGRTFVAVAFGGNSQIMTSSDGATWTAQDSPAESKWQSVTFGANMSVAVASDGEDGEFVMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAM6</accession>
    <name>B7GAM6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184220.1">
        <property type="nucleotide sequence ID" value="XM_002184184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAM6"/>
    <dbReference type="PaxDb" id="2850-Phatr40158"/>
    <dbReference type="GeneID" id="7195931"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40158"/>
    <dbReference type="eggNOG" id="ENOG502RB8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466523_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAM6"/>
    <dbReference type="OrthoDB" id="72550at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="643" mass="68220" checksum="26DE922DEB4671E7" modified="2009-02-10" version="1">MADYGSPGSPRTPQTYQIDFSAVASGKRIASSKRRVRWRFGFANSEALASGETGTACRGEEHDVTLVWSIASGKRLILVDGHEVHYSSSRNAIFDFSWTMRGNHVLKMVAHVSPPLSPTPGFRQYDFFIDGQSFFTFPKVFRLGLAPGQAPASPSGASTSYAGMAPTSARRSASGEIVSMEAPHNPDEEEAYLQEAIRQSLRDDTPASTSRGAPTNPTSDLLDFSSPPAGAPTQTYSPSTNDLFSPQASATRKQQHVCLARFYYVGSLGSSGSGSTTDPWGASAPATHYGYGTPAAGPLPALTGPAPAATGYGGYNTDPVQAPYGAPALYPPPAQSYAPAPAQYGGPEQTHAPDPVQAPYQAPVQSPYQAPPPASAWQVPAAIATQPPYGQDPSIPPSVTPQAQATPSTIGFSSPPPDFSGFSSAPQASEPAQAPSSDPVVFSMNALSGEQNGLVDSNSTAQSASLVDQAYSKLVNMDTFSLVSKNDEARSNPFDMGSTTVGGNVPLAQMSKHKSQTAPKKEVMRSPAPPPGSMIVASNHNGNWGGQYGQPQQPDMQQAYGQQQSPMQQQPQYGQQQPPMQPQPQYGQQQPPMQPQPQYGQQQPPMQQPGQLGQHGQQHFGQTNQMQYGQAQQPPAQPGYNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN1</accession>
    <name>B7GAN1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_40163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184106.1">
        <property type="nucleotide sequence ID" value="XM_002184070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN1"/>
    <dbReference type="FunCoup" id="B7GAN1">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAN1"/>
    <dbReference type="PaxDb" id="2850-Phatr40163"/>
    <dbReference type="GeneID" id="7195933"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40163"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_2_2_1"/>
    <dbReference type="InParanoid" id="B7GAN1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="196"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC44284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="371" mass="42224" checksum="5D1C54CB231A9416" modified="2009-02-10" version="1">MDGAFDLLHYGHMNAFRLGRSLGTHLVVGVNSDESISQCKGPPLMNDEERMTMVSACKFVDEILPNCPYIMNREYLDYVIETYKIDYVIHGDDPCIVDGKDVYAAAKEAGKYRGIPRTEGVSTTDIVGRMLLMTKEHHYHNETSSIDERDDEVPKSPGSSREWLGRQSKFLTTSRMLQLFSADVQAPTPHMRVVYIDGAWDLFHPGHVAILRAARERGDYLIVGIHGDATVNRVRGMNLPLMNLHERVLSVLGCRFADDVLIDAPYDVSMEMIASLNISEVVGTNDHDIGEFEMKSQTHRYRHAEQAGLLHLMDIPSKFNMGRIVERIQRNQEAYQAKFERKMAAEREFYEQKRASEYDAAFHEGRVTFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP6</accession>
    <name>B7GAP6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_15870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184230.1">
        <property type="nucleotide sequence ID" value="XM_002184194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP6"/>
    <dbReference type="STRING" id="556484.B7GAP6"/>
    <dbReference type="PaxDb" id="2850-Phatr15870"/>
    <dbReference type="GeneID" id="7195941"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15870"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1520743_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAP6"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47105">
        <property type="entry name" value="OS02G0173600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47105:SF1">
        <property type="entry name" value="OS06G0665100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31802" checksum="6F4F77ECA323AA5D" modified="2009-02-10" version="1">MGTWPKIHPKRVRVITCDVTGTLVSFRGSIEEHYLGSAQKCGIDFVPDDPASSTGHNGPLPIHKAFSQGYRECCQIYPCFGGHDISAKEWWKRCVLRSFELAGARMNEAQQEAVFQRIYSIFGSQACYEKFDDALPFLQWANRSRIVCGVLSNADERYGDSILPMLGLTHDELQFQCFSKDFGLEKPDARFFLAALKQAELYLVSQNSYDVNDPLLPSQVLHIGNDFQKDFEGARRAGMHAALLSRYGEDELAAEWKRRGALVFEDLLDVVELLGRSNCQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBR6</accession>
    <name>B7GBR6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184493.1">
        <property type="nucleotide sequence ID" value="XM_002184457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBR6"/>
    <dbReference type="PaxDb" id="2850-Phatr49745"/>
    <dbReference type="GeneID" id="7198334"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49745"/>
    <dbReference type="HOGENOM" id="CLU_473696_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBR6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="368"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="453"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="576" mass="65485" checksum="311F32636EF35D4A" modified="2009-02-10" version="1">MDSEALNDFIWDGQWESVYEALCRYICIRGSANVPIQFVVNGLKLGKWLYEQRCKWGQGSLSPKQVSKLVEVGVQPLSSLNKMRLPPTYPQQLPDHVSSTLLTLPPVRRISDATDCRSPPKMSPERSDEGWRSSKCVTPRDSGSTMAIPSSSALGELQRSSFLGRRMMMPSLSSVTAAAKASHRRQHLEMMLLAEERRIAQEQALAGQYTGYSQEHIRTAGKSNHFAAYSDLIMEAQNRFELSANTTSSSSFLPRSNDPALSHQMSVHPDLTSSRLGNREKMAAATMNRLPPLRVNPLMDISTPEAPPGWCTRRKKQPNKHVILLPEEPDDDEQDRSKIKRQLFVSVSDESTLCTTPMLPKKTSALNAWDSKLVELVRFEKTFGHMLVPPEFRTAEHRLGAWVRHLRVLFEQDKSRCAVDRKAKRSQLSGYRVKRLDAVGFDWHATEEQVQNKRWGVYFQLLRDFFQKNGHVNVSATHKVSGMKIGNWVRLQRIARHEGCLNPDQTSKLDALGFDWELERDTQSSSNEKQNPNRPSEDDTMRLLKRRREEQEQLSSDCGLSLLSSTATKRMVVRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDF2</accession>
    <name>B7GDF2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185120.1">
        <property type="nucleotide sequence ID" value="XM_002185084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDF2"/>
    <dbReference type="PaxDb" id="2850-Phatr41149"/>
    <dbReference type="GeneID" id="7199017"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41149"/>
    <dbReference type="HOGENOM" id="CLU_2282922_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDF2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="11553" checksum="7948EEB13D6657BE" modified="2009-02-10" version="1">MIDAAYILAWMGIVLLQAVAHYSVSARKRFDPHPLEATEDVCLDEVPPREQLASSIDEQDERSDEDLDGEEFDRLLSQTGSEMMNSCRSLESIVQEKICHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDU2</accession>
    <name>B7GDU2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_41291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185270.1">
        <property type="nucleotide sequence ID" value="XM_002185234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDU2"/>
    <dbReference type="PaxDb" id="2850-Phatr41291"/>
    <dbReference type="GeneID" id="7199178"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41291"/>
    <dbReference type="HOGENOM" id="CLU_450937_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDU2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="101" mass="10857" checksum="08FE98644E66DE1F" modified="2009-02-10" version="1">MTVLSTGSRDGEHYLGCGTQGEPVETNLVCLATNPDTDGFGQAQSQLSIQKHDVTVLGLDRCHAKEHGNYDECAHGAVYNTVENSETDHDDAWQIVGPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDU7</accession>
    <name>B7GDU7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185272.1">
        <property type="nucleotide sequence ID" value="XM_002185236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDU7"/>
    <dbReference type="STRING" id="556484.B7GDU7"/>
    <dbReference type="PaxDb" id="2850-Phatr50353"/>
    <dbReference type="GeneID" id="7199136"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50353"/>
    <dbReference type="eggNOG" id="ENOG502RGMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567088_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDU7"/>
    <dbReference type="OMA" id="YRCAAEP"/>
    <dbReference type="OrthoDB" id="38729at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF33">
        <property type="entry name" value="NITRONATE MONOOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853169" description="2-nitropropane dioxygenase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59625" checksum="A27FBF6DCA012AB0" modified="2009-02-10" version="1">MKQFGIFSLACALAFSSLAPAYAYSVAPSVPSIIQGGMGIRISQWKLAREVALKGELGVVSGTAMDNVMVRELQKGDAEGSFFRALKTFPDQDMANRIVARFYIEGGKDPSEPYKSIPMWTLTPNQLLLEANVLANYCEVWLAKHNDDGSIIDGLVGMNLLTKVQLPTIASLYGAMMAGVDYIIMGAGIPISVPGFLDNLSECKDCEQKIDVDGVAEKEAPVYKFSPIAFWEAAGKPELAAPLKRPSFLPIVSSTILAQSLLKKASGKGPTRGIQGFVVELSSAGGHNAPPRGFKFDPVFSTHAGGLNERGEPVYGPKDEVDLAKFCKACQGLPFWLAGSYARPERFAEVRALGGAGVQCGTIFALAEESGLDDWIKQDILRKLSETRLDVLTDPAASPTGFPFKVLDLPQSLSQREVYEARPRACNLGYLRQPYKRPDGKIGYRCPAEPEVAFARKGGDAKATVGRKCLCNALCSNAGFPQVGEVKAVNGEKMKYVELPLITTGDDISSCRDFIKEDADGHLGFPAGEIVDYLLSEWKRKPVGSAAEGSMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE41</accession>
    <name>B7GE41_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185368.1">
        <property type="nucleotide sequence ID" value="XM_002185332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE41"/>
    <dbReference type="PaxDb" id="2850-Phatr50434"/>
    <dbReference type="GeneID" id="7199302"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50434"/>
    <dbReference type="eggNOG" id="ENOG502SFUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1312320_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE41"/>
    <dbReference type="OrthoDB" id="272750at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF17">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856140" evidence="1">
        <location>
            <begin position="28"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="258" mass="28487" checksum="35AB4D9719025015" modified="2009-02-10" version="1">MAPSRIARLHFCARAVLSLLALGTVFAWVPTGSGVHHRCRNGKTPILGMSAGKNDGDASPSSKVRFLGKGERAIVRPGVVLLAPTNEYHHYYRQAAIFVHAMGEDDDDVYVIRGVILDQPTPFTLGEMMEHNPALQKTPLKDNLLFRGGDKGGDQVVLLHNHEEIGQSSIGVSGVFQGGFDQAMAACEKGHRQTSDFKLFFNYCEFTELEMEDLLASDEDGDAWISVEVDSDFVLNDGWERGDAWSRLRNAVQQQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE50</accession>
    <name>B7GE50_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_50443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185374.1">
        <property type="nucleotide sequence ID" value="XM_002185338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE50"/>
    <dbReference type="PaxDb" id="2850-Phatr50443"/>
    <dbReference type="GeneID" id="7199255"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50443"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_1_1_1"/>
    <dbReference type="InParanoid" id="B7GE50"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF19">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853265" description="Cytochrome b5 heme-binding domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="517" mass="57763" checksum="58DDD5E2DDBE84BE" modified="2009-02-10" version="1">MKFLHSALIVLTSASASSAFTATNFFCLSQYGSSVSGCPEDFIRQWKAAGSTTNRISKKNVAYDCDEDANCVIVDACDDEQCRTSLDVRIHGKWYDLSGWRKAHPAGAHWIDWYDGRDATEVMDAFHSEKGRAMYKRLPASSTESVAMLETTIAPDSSTQIAFRQLRDDLEKEGWWKRDMVHEFTQLGIWASLVVGAAVTAHSAPPLATFLLGLSMTAAGWLGHDFIHGVDSFTDRLRNFAGVAAGLGPTWWSDKHNKHHALTNEQGVDEDIATDPFLFTWAPDPKDDSPLRKIQHLIFWVPFSALFALWRVDTMQVVIEAVENKRVGAKGELYGLLLHYAVLFTVFPVTVWLPAIFLSGLMSALIVTPTHQSEEMFETYQPDWVTAQFQSTRNAVTTNPFSEWLWGGMQYQLEHHLFPSMPRNRYPALRERLIQFAADNKIPGGYRESGEFEILRMNWNLYKSVAEADAVPGAPPTRGRLGQQGAIRETNSPAAQQEKAKIDQTVAKGNGPALESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3J8</accession>
    <name>B7S3J8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1122</name>
        <name evidence="1" type="ORF">PHATRDRAFT_bd1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999282">
        <property type="protein sequence ID" value="EEC42730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS999254">
        <property type="protein sequence ID" value="EEC42875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176138.1">
        <property type="nucleotide sequence ID" value="XM_002176102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176283.1">
        <property type="nucleotide sequence ID" value="XM_002176247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3J8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1122"/>
    <dbReference type="GeneID" id="7204940"/>
    <dbReference type="GeneID" id="7204954"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1122"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1296"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3J8"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="383" mass="42788" checksum="98B28427EC276CBF" modified="2009-02-10" version="1">MTDARIVSATANTKVPADMARRMERVTKKKPPKQVLVEFFLNADEIQSRPLNLAERITRSFAPQPGAVEREAMDLQDQTLRIFNTELLEFAGIVMRLSLDHSFALLDSDWQRTASDRDALECKLEVEAAAAAAHGVSRIPVEKQHDNACDDNSDPTSETNKARGIMGFARFMAKNAKKSIASAVKTVEKMMGDGSELLNPPDHRPLCKEERQAILLMQSFCPQQSTPDYMVGTTIAQGFSRCMPNLTPPVLTRTGVVRGDVARLPHQGIEGFVRDNVIRRDVFDNARDYHNVIAECQTLQVDDLLLNLEGSILDEEKAVKLVTWWTKYSRVDPNATATKSLALKDAIRFNENLLTDTKDKTSAGRSIVLMRNLLFFVAKKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7S441</accession>
    <name>B7S441_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_bd1680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176308.1">
        <property type="nucleotide sequence ID" value="XM_002176272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S441"/>
    <dbReference type="STRING" id="556484.B7S441"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1680"/>
    <dbReference type="GeneID" id="7205024"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1680"/>
    <dbReference type="eggNOG" id="KOG1307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421216_0_0_1"/>
    <dbReference type="InParanoid" id="B7S441"/>
    <dbReference type="OMA" id="XSSRKFF"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="496"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="651" mass="71375" checksum="65B75CFA226D0839" modified="2009-02-10" version="1">MQNDQDEVPTASIAVWIGLTLATCLSFWGQAVVTEERFVPALNVVANLFSIPDDIAGATLMAAGASSPELFSSFVSLFITHSSLGLGTIVGSEIFNQLVICAGAVYAAKSGSLQLNPAILIREVGFYALGIGLLYYALRDSAPDPTDPSGENHIYISFGESALVFGGYVLYVIVCANMEKIVSLFDKGTTRRDGMAHYGAIGNFSKHVLVGSDIRHSVKIDSLPFLQNQSLAHQEPAENFHELYLGRMTERASIFQRTGSSTISEDVGNGSFGGSARGTSLLEKSLRHTDLFRLMVNEVKPSDQHGLYDMEINKVEGRLSCFMWQRSYFYNKARMATHGWHLRWFTLTNHKMVSVPDRTDFEKHRIVYPPFTEVSVDEARLIIRIENEVGKRNFYIMAPSAEILATVVQKMDDTMQGHEEVERRATNGTGDSEDLDATEAAEDHVPLIELPVGGSNMEIALFFLLFPLRYLIHHTIPDVRTLDHHGNPTATLPKALLASTSCLVWLIVGSYIMVASLEALAALMDIPDAVVGVTVSAAGTSLPNYVASRVAAQNGFGNMAVSNAFGSNTFNIMVGLGLPWMLYTSIGTGFQPYHGLRDEGILQSVIVMASVLMVFVVLVSLSKFLLYRWHGIVFVMMYAGYLAFAIGQVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7S457</accession>
    <name>B7S457_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_bd1692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176343.1">
        <property type="nucleotide sequence ID" value="XM_002176307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S457"/>
    <dbReference type="STRING" id="556484.B7S457"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1692"/>
    <dbReference type="GeneID" id="7204941"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1692"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_3_1"/>
    <dbReference type="InParanoid" id="B7S457"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26409" checksum="C00946FB47E0EB2B" modified="2009-02-10" version="1">MLIAEVFGTCMFVQIGCAANAVALYTHNSTTMTIDWQVGVVWALAMTVAVFLSAALSGAHLNPAVSFSFALARPADFRFRKLIPYWAAQLGGALLAGIVNLFLFHQAISHYEKKMAIVPGAAGSIQSAAAFGCYWSLNSKYISNGVHAFFIEAFGTGVLVFCIFAATHIKNPLPGVAVPPIIGAMYGVLVVTLGPMTGGSFNPVRDMGPRIVSVIGHWGPTALTNFLPYLLGPMIGGPIGAFLADKVLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7S462</accession>
    <name>B7S462_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_bd1693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176391.1">
        <property type="nucleotide sequence ID" value="XM_002176355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S462"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1693"/>
    <dbReference type="GeneID" id="7205031"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1693"/>
    <dbReference type="HOGENOM" id="CLU_985050_0_0_1"/>
    <dbReference type="InParanoid" id="B7S462"/>
    <dbReference type="OrthoDB" id="10607435at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="283" mass="31381" checksum="E6D0B08EED2E3BBD" modified="2009-02-10" version="1">MLSSITTIARRSTLAASQKATVPLLNSLANRSFSGPRKASSERVPDEDYYDGHLMTDHLEYLDDMLDNALKMETSMEDLKGTYAKKRHAFENVGWMNRAEIDLLFDEAAMHKEKISNQISDLKRLVREARQTLAVDSPEGIPDGEVKDNIAEVNRLIQAAANHEDTAEILAAQRIVAVDGPDGNPDGSTGEDLREIDRLIDHAATHEDARSIEVGHQMGADQSAFAVDAPDGLPDGSTREDLYVTEQFVADAAKMEDANTIKLQHKMEDAVRNDRARDAEHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4D5</accession>
    <name>B7S4D5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176378.1">
        <property type="nucleotide sequence ID" value="XM_002176342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4D5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft276"/>
    <dbReference type="GeneID" id="7205150"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd276"/>
    <dbReference type="eggNOG" id="ENOG502SAWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473703_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4D5"/>
    <dbReference type="OrthoDB" id="47270at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.30">
        <property type="entry name" value="sav2460 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051324">
        <property type="entry name" value="Stress/Tellurium_Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32097">
        <property type="entry name" value="CAMP-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32097:SF17">
        <property type="entry name" value="CAMP-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="142" mass="15596" checksum="C160A894231952DA" modified="2009-02-10" version="1" fragment="single">SIDLDASAICLDSNMELVDKVYFGNLQSSDHAIQHAGDQRSGDSAGDDETISVSLQMLNPRITYIGFVISSFSGQELDDIALASCHLYDTASVRDIARYSLTNARALDKHTALVMGCLYQDEGREWMLRIISKPAQGRSVHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0A2</accession>
    <name>YCF4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem I assembly protein Ycf4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycf4</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for the assembly of the photosystem I complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ycf4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874368.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0A2"/>
    <dbReference type="STRING" id="556484.A0T0A2"/>
    <dbReference type="GeneID" id="4524570"/>
    <dbReference type="InParanoid" id="A0T0A2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00437">
        <property type="entry name" value="Ycf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003359">
        <property type="entry name" value="PSI_Ycf4_assembly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002712">
        <property type="entry name" value="PRK02542.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02392">
        <property type="entry name" value="Ycf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000275680" description="Photosystem I assembly protein Ycf4">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00437"/>
        </source>
    </evidence>
    <sequence length="181" mass="20477" checksum="8058691092597671" modified="2007-01-09" version="1">MQNEIRQDKIIGSRRFSNYFWAFFLLVGGLGFLLAGISSYFKVNLLPFTNTTELVFIPQGLVMMFYGALSLGISIYTLLTIILDIGSGYNEYNRIENLVKVVRKGFPGKNREILLTYSLSNVRAIGIKITEGLNPTRSIYLCLKDERNIPLTPVQEPTAISNLEEEATDLAKFLDLRLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y416</accession>
    <name>B5Y416_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_36922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185928.1">
        <property type="nucleotide sequence ID" value="XM_002185892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y416"/>
    <dbReference type="STRING" id="556484.B5Y416"/>
    <dbReference type="PaxDb" id="2850-Phatr36922"/>
    <dbReference type="GeneID" id="7204718"/>
    <dbReference type="KEGG" id="pti:PHATR_36922"/>
    <dbReference type="eggNOG" id="KOG3568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421214_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y416"/>
    <dbReference type="OrthoDB" id="193961at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838768" description="DOMON domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="6">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="645" mass="70886" checksum="B8511DA8C0A55430" modified="2008-11-25" version="1">MIQSSWTLLALYSAWWSSLGSLVSGQTLFNQPTEYFSNSTDPVSTQFYLDWVDTTLERYDASLFLSAANNASNGVAVHWSVRADTPDTITDNATSTTLRLAVAAPASGWVAFGLSENGGMSGSDVVVFEAAQPDRLRDMHILDTRAVMDDVCNDWTLIEAHLAENFVIFEATRVLDTGDPQDRIIFPDADTLIASHRIIAAWGNDESVSYHKENKARGAIRWFGEGAVEALTFEQTMRAVSIGSFEVRAVDHPVKTIDTEYAEFCLGRGQILAQTGLDGSPDSLTIVGMEPIIDPSTSQFVHHFTVYTSPNANEDGVVPCDDREYFELIYVWAPGEYGFALPLNVGATYGPNVAQSFRLQIHYDNPSLIADAVDNSGVRFYFSKQPRKHAMGVLQLGDPFVGLEGQTVGAGWNKHDFTCSGSCATMALGEEPVTVIREFLHMHQAGVRASNKQIRDGRIVRSSAIDYFSFAQQGNQAVLQDPFQIFPGDEFKTSCFYKGNTDTVFGISSQEEMCIAFLFYFPRKRISGLLPWLCAVGYDHFVPACESQWSSLVLSTTIELERIFGTVPEESQCLLKTTPVEIPTKAPVAVSNSNSIPNNKPANSSESTLDPTSGAVERESSGLILDFDAICRLLLPMTLLTLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4J7</accession>
    <name>B5Y4J7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186305.1">
        <property type="nucleotide sequence ID" value="XM_002186269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4J7"/>
    <dbReference type="STRING" id="556484.B5Y4J7"/>
    <dbReference type="PaxDb" id="2850-Phatr43856"/>
    <dbReference type="GeneID" id="7203976"/>
    <dbReference type="KEGG" id="pti:PHATR_43856"/>
    <dbReference type="eggNOG" id="ENOG502RDF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330540_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4J7"/>
    <dbReference type="OMA" id="NTDEERW"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="763"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="985" mass="109570" checksum="4293370541560F60" modified="2008-11-25" version="1">MVSNSNTKGVNFASFVPHHNVPESDVEEATETAAKPPTHGVPEDGSEKMPHSVELVNAPTDRMKRLASAPTVCTLRDHFTLPIASSTVRYRQTQGAARVIQGGDAQYVLEETVNRNTEQREISIRRIHDTSEGVRFLRATYATVTAFWTGFLFVFCLQVLLFLVLDLAIEVGATSKQEANWGAAMGVIFSIIPFVYGLSSALVIAGAYIQDTFRGHPLIRNFTFRKLSPVAVEWIFFTFFLGAPIFILCCSLLSGSDSWWEITSLFWFASVLAFYVIFAGNVIWYELRACWEVTRNLRDDDNDDFWHVVYRSIRSRQRAVYSGRKSVTYLSMGSIRDAEFTDSLSTRKLQVDGTMVEKIGLRSKATEWKIWSDLGFYKELDQPERFFTIDDARDVRPYLTSYTWNLEKVFCRPRDSRYIAIVKGPGAVTRAQMKASFICSLLGTFLMFFVLFSALIYLELGGAFTTLILAAGVLVCYPSFVSTFRLYRATQRLVFARSQAKDSDESDDEEKEEDGMAASKGIFLVHEQYRINVATDRLCFLMFAIEVMLMLVWPLASLYSVGNWTLASLFVIVAGISGVRYYISAAVVLEETGHLDLVDGNTDEERWQNQSRLNEIVGNITVGRSRGAWMSVLGTFGFVVLALFVGAVGTNQETTAAVAGVGNTYLPSNEFVYQQKDSLRYPTCALTSAAVDQTPLNTMADYTFLAGLAYSGDQVASEAIAQWFSEGAILQDTVVAEYRNRTGVSSAVSFKLFTFPSSADFAIVSIRGTQNNWDMLTDAQLWSSAALMQFLRELLPFGEIWTPIMDSLINIITSIESESIERVSFYKDTTRFVQFLQNQSDVYSGVAVTGHSLGGGLSIITGAIAGVPAVALSGPNAMLSRKSFDPQVSAEQLNSKTFNIIPERDVVPMIDDPAQNYQSIRCEADFADFIGCHDSTRSLCEILYTCGNDNRPIPCECHTLYNYPQPIQTAASNRTFAEACGLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4M4</accession>
    <name>B5Y4M4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_10187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186037.1">
        <property type="nucleotide sequence ID" value="XM_002186001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4M4"/>
    <dbReference type="STRING" id="556484.B5Y4M4"/>
    <dbReference type="PaxDb" id="2850-Phatr10187"/>
    <dbReference type="GeneID" id="7204293"/>
    <dbReference type="KEGG" id="pti:PHATR_10187"/>
    <dbReference type="eggNOG" id="KOG2352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065920_2_0_1"/>
    <dbReference type="InParanoid" id="B5Y4M4"/>
    <dbReference type="OrthoDB" id="44301at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="171" mass="19673" checksum="BCC527B7A3FA8D3D" modified="2008-11-25" version="1" fragment="single">NSTYGSHDYWEDRFENEDSFEWLLSYEQLAAQIEPHLLPVSRILVVGCGNAPFSADLYDAGYHNIVNVDYSETVIANMQQRHLTERLQMEWLVMDMTDLSALMDASFDVVIDKAAMDAIMTKESDVWNPDASVVRASRDMCRHISRILRPDGGVFLQISLAQPHFRKRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5T4</accession>
    <name>B5Y5T4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186521.1">
        <property type="nucleotide sequence ID" value="XM_002186485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5T4"/>
    <dbReference type="PaxDb" id="2850-Phatr44235"/>
    <dbReference type="GeneID" id="7204066"/>
    <dbReference type="KEGG" id="pti:PHATR_44235"/>
    <dbReference type="eggNOG" id="ENOG502T1Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441785_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5T4"/>
    <dbReference type="OrthoDB" id="56838at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="619" mass="70012" checksum="1DBD9C6A21F20A47" modified="2008-11-25" version="1">MGRFRYHEEDDGANDGEEDQFRTEQSRTIGSSKSWRSNPEWEFVAQGVSEQGALVSRDIDQRTARVESTSNSANMENNPFGPSESNHNPLFSNTRPTFIVLPQSQSIAEGDGSEWCDDYSNNQDPTLWRRTYPGSVWIPTWVRTILLAMVVQLALFGSSRYGPPAPPLPNTIADDSTITDTEPTTWNDYVSLHGFQLWQSTRALFFDTPLHLAGWGWMHIHTELRDLYQDYRGTSRWNSRPRPCSLRISSDINLWKAFESSMVGQPLAVQILTERVQTWNRDSPLLFFATGGIGEGKQTALIHLARHVLMPHCFNAVEHSSEAQSEAVLLLLDGQDFLVDHEALRETLQAKLATRILRHVKKMQEGSIILLKNVEHMEPSLLSWLLHELGETGYNDLQTSTWQLRKHCRQSVIMFTSTEIGRMAITQSIRTHGTSEIYSQASLVLDVGHELMRHLGGRALEWPAIVPFFPLTQKDLSAILDARVRHHSTTYADTQWRTFSLTSSLKTALLEPSSQVEYVAWKGRQGSDPDATTMSFTFSSTGAQVLGEGGPVWIKIQAQLNRCVFSRPLKKRSDQDVVMDYDARIQRGMVQQCEYDGACTELCRFPIHTPSLSTYGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNU5</accession>
    <name>B7FNU5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_42587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177100.1">
        <property type="nucleotide sequence ID" value="XM_002177064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNU5"/>
    <dbReference type="PaxDb" id="2850-Phatr42587"/>
    <dbReference type="GeneID" id="7196277"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42587"/>
    <dbReference type="eggNOG" id="KOG2556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289269_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNU5"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC51563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116871" checksum="F72EA4860FAC0C4C" modified="2009-02-10" version="1">MVFHSRKRSWVYMGWSMLAGSLGPSWSNQMETAQAARPFTQHVVSPATRLTPYEGEFRQSAIPFPCGSSQGERESSEPVFDHDQSEREFYTSRNEVRALRTAATGNDYWHDVHADAVRTNPDILFKGLKKRRKRQSQKGSTSDADTEPSLGYRVRRASNQGDEDPPVESEEGNFVNADIDIPLPETNMSVPVSERPLSNDFNVTAETQYNVSVSVSHGSNSTNDTVTAVYTQNEQTNKTVAPPFRPIRIRAFLSETDGGGVHLSEAQHQILLQDTVRPALLAWSAALRVNPVVGNLTIDPTQLVDGVSCGPGLDSGLPSVPVPDEHILWGVPNTDLIIYLNLGFVQSNPQNVTDSLNVSGTNASIFSEGPAVFPSKPKRYFNKSELVIPRNETTNETDSEQWNASFVATYNMTSTVPKKTCQGDYLAASSFCTMDQKDRPTAAILHICISENFFDPLMLETNIMTVMHELGHALGFNSVSMALFRTSDGTPLTPRNEKGAVPDTVVECSGPKGNRGNATVPLPSAKILQFREVRGGVRVAEIVTPSVQKVVRNHFDCQGLQGAELESGEFLPLSTSPGEVSCIGDHWERRLFKNDILNPIVDELEFHPRFSTITLAYFADTGWYQVDLSRASLAASWGRGAGCAFVEEACIRQDGQVPPSYEPFFCNQATSIDDAGFVSDISGCTPDLSRKAACSIGQYTNELPREYQYFNLTFGANVGGNDPFMDYCPVFTGFSNGLCSDSQNEALIRVNQVERFGQRNSRCLSGRVGAYKAAFCLPIACVVEDHSLRIQVDGEWKKCLFKDHHILSSNGDRIICPDPIRICPTFYCHRDCLGTDRICNYREGKCVCNGTFAPADDGVSCTTPVEPSGVIPAVFYSPPTMNNQDLPDEDSPLADYYVPSERALKEDNPIFIEEIRYLVVVAVIFALGIVAFIWIWLRRNRAFDTQLADGGADDSPPTDATHNPNKDKMIASVIVDLRVNGPSQFQYRDALRERESETDVSLTDTEGTGTTNAANSAENAGAGESIFGLHGAENEAPQGDRIIRRRRYFQHQQPNDGEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNW5</accession>
    <name>B7FNW5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177110.1">
        <property type="nucleotide sequence ID" value="XM_002177074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNW5"/>
    <dbReference type="PaxDb" id="2850-Phatr42603"/>
    <dbReference type="GeneID" id="7196287"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42603"/>
    <dbReference type="eggNOG" id="ENOG502TKTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510451_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNW5"/>
    <dbReference type="OrthoDB" id="45409at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="506" mass="55613" checksum="1A8D08C5A071DDC1" modified="2009-02-10" version="1">MGSSDDSNCLVPYERLTEAAIFARGEDEGFRALEQLSILCAERFSFDLVEKPAFKPNDSVISHIPGLIPKNVTELVWNKVYQMERNGWMSSNPDSVDGLPSLHLNLVTGGRQIFTKASCEGGDSCESFENGICDLIELISPFVYYELLPKVNELLNTTTIKVDDIFLRRYGDELTDGMSRNGISAHYDVFSRLTSVIALDDTAAQGTNGLYTTQQLIADTKTFGTTSNHAALRRFFPLQCGDGVVHTWDVLHGVHIDPGLNRTSLIVWFTDSDEPTQTNVPSWISKRSDLESNDVTQFVLASSLESASILSGELEQQCNNPVPRRSLEDATLPTTGASGDHLHYFDFYLESASRGNSFALTRLGRACEEGLLSSQGLHRAQEILTRLQPSMCLDLPGVPGLHELHSPMNLAKRFWLEGAVRGNAIAQIALGDECMMEASETGDSDVRLLAAVLFALAAQQPGNVHAFDSLARVIDFEVADEKIRNDEDFASSFIVRIAHSVQSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNW6</accession>
    <name>B7FNW6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177111.1">
        <property type="nucleotide sequence ID" value="XM_002177075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNW6"/>
    <dbReference type="PaxDb" id="2850-Phatr42604"/>
    <dbReference type="GeneID" id="7195972"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42604"/>
    <dbReference type="HOGENOM" id="CLU_1921188_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNW6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="132" mass="14829" checksum="0760CAA81B2D413E" modified="2009-02-10" version="1">MTPNSAHAILSILHDQARQNNEPTTKTIAESMHNTIEDLSTEFAKESATIQINPPKRTNTWGEHNSVVMATMYGNRMTNCQDVREIYAECHAAHSKDNICKTAASYFSICMMGSRIEKDQSRLVSYQDSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPH8</accession>
    <name>B7FPH8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_7349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
            <location evidence="2 9">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176715.1">
        <property type="nucleotide sequence ID" value="XM_002176679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPH8"/>
    <dbReference type="SMR" id="B7FPH8"/>
    <dbReference type="STRING" id="556484.B7FPH8"/>
    <dbReference type="PaxDb" id="2850-Phatr7349"/>
    <dbReference type="GeneID" id="7196148"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7349"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="InParanoid" id="B7FPH8"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="87" mass="9744" checksum="4D3B0EFC86A4EF9A" modified="2009-02-10" version="1" fragment="single">EAGCVAHDVESELLCQWQLADKVPYFNAGIYLENKRKIGKVDEILGKVNNIFVTIKMDPGILSSSFQPKDLLYIGTDKLLPISRFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPJ4</accession>
    <name>B7FPJ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177222.1">
        <property type="nucleotide sequence ID" value="XM_002177186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPJ4"/>
    <dbReference type="SMR" id="B7FPJ4"/>
    <dbReference type="STRING" id="556484.B7FPJ4"/>
    <dbReference type="PaxDb" id="2850-Phatr42788"/>
    <dbReference type="GeneID" id="7196404"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42788"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264053_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPJ4"/>
    <dbReference type="OMA" id="AWSENAN"/>
    <dbReference type="OrthoDB" id="39740at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855251" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="50"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="445"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1270" mass="143469" checksum="F6194BBDD0FAAD20" modified="2009-02-10" version="1">MKPLFKPISWLLLLHLPIVCASENGASSVTIDHGKALVDWIRSKGGFFHSKIELRRFDANDPTSPYGVFANEDISDKELLFEVPRSCLLDAINDYKVGDKIEGFFVNKEWHPATVAAFYPEDDTFDVAYDDGDFESRVPRSSIQWPSSAMNCGTVRSLLREFDLGEESDYAPFTNYLREQPYGQLPSAWSVAGKSLLLEMLGQDLSGKQTLPPFEALDWLTSGWHNLCRGSTDPFAENAAMMVVQRCWDELLIPIYDMVSHRNGRWLNTQSNSVQDGGPVSVTASRKIQAGEELYSTYNFCTDCDARAHWYGTGEILRDYGFVELYPQRWLFPDQKISFDIDEKLNEEGKPTGEMIIHWNGLTATTLDFLEKQIRRLDFFAETELRSRDVEVLDYEWDTINQYHQALSIAMKEAARHLASQSKTGVKTTCSDGEGPCALTSTIYDSLEQEEVEAWAAYRPETCKFKDLFKFDTWSVTEEIKSPYQKIAFFSDPTMKDTCFELDAIVQICTSYRPHYHEMAVHYTARFLDKIQRVLFVGGGDSMLLHDIIKYPSLELVVGLELDQKVTRGAFKYYGAQPHWDNEKVEWWYGDATKSLLMIPKEYFGSFDMVLVDLSETVMSFPVTRDLDVMEALSLLVKPDGIFVKNEYNYFKEMSEIFEHTVHVFYHDVPFVCSQSLMLGSDKVDFLRTPTTDHKVDYVYNLLDSNDSLDNAHDYQRNYTSVHRQISCQKDDEEELGVQERSPGILMIVEVEKATAALDLQSLERSLTSALKQEGLIVLSTVLSEEAGNSIVLIFAEGYVVARSMSQDAYCAFDIQLWSSFEKQDSIRKAVIAAVGSDSVGASSSAYRIVSGGMFGAEKWKSDAKSIGPHMNNLCLDPVEQIRNIPIDDKIVETVLNESMSLVQDESFIIGVLCGQSGQACKSAEILKKQDKIEEVVTLATCLNLAPGAEFAADGLAQMETCEKEVWKLLSGSLSARGKKLRAIVIDEGASSTMARILFRIFRSSRNAKRWLAEDILVQAPTVDHSESWRSVFVDEFRREIFKKEPVYTAEVYFNTTASSLKLSITSAGDEHFVRHLVDFATKAEQSAEVVSEVRSVRGALEFKFFDNYRPSQLFEPDAYDQSSSLEQWNSQKPLGHQTVFQLETEGSETSMSLTTIKESLNSAIRSIVPENTPEVKIEMFTEMGDGCVFVALWAEGNIVALWDGRKHVDLNLFTFIESVEVADTFVLQFGAEDPKLHTVLRDDQPRGTGRVVNFKTDFEPGKSPIWSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPN8</accession>
    <name>B7FPN8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_42820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177244.1">
        <property type="nucleotide sequence ID" value="XM_002177208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPN8"/>
    <dbReference type="STRING" id="556484.B7FPN8"/>
    <dbReference type="PaxDb" id="2850-Phatr42820"/>
    <dbReference type="GeneID" id="7196481"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42820"/>
    <dbReference type="eggNOG" id="ENOG502SEE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648080_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPN8"/>
    <dbReference type="OrthoDB" id="432829at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162:SF10">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN-CONTAINING PROTEIN 9 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162">
        <property type="entry name" value="OS02G0192300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="419" mass="46869" checksum="60E764BBA5B61126" modified="2009-02-10" version="1">MEHDTGGSFLSPAERTMLLKEIEVFEKLEASLKSTKRGNLRKPRSVHAGSNKPRTRDSGFREAPRSTGCLVCGIDRDHTNILLCEGCNGEYHTYCLLPPLKSIPQDDWFCDDGDGLEQLVSSLPPNFTTRFAEICWAQGGNGYGWWPCCIYDPRLTVGDARVLARKNLGKKHLVYFFQCEEAPFAVLPTTKIQGWTEGLVDSFYMGKAAKAAGKCRYIQFRKAFQAAIIEESKPLTQRLEWNQLGFPPQASLAARPASPQKTPVNAKKRPTDCLIEGSRTKRAKSSVSLDLARNDIMEKREPARYVETSESGTEMFCKVKRKLLGAVDKVEIGFVLLPCRFTSTFADVRRAISIDLDEELPSNWDWRFYVPPLGPLSIKQESRFGAMLSFLRKAAPHSDIGEGSLQKPAQVVLVDAPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQU9</accession>
    <name>B7FQU9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177468.1">
        <property type="nucleotide sequence ID" value="XM_002177432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQU9"/>
    <dbReference type="STRING" id="556484.B7FQU9"/>
    <dbReference type="PaxDb" id="2850-Phatr43164"/>
    <dbReference type="GeneID" id="7196764"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43164"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_3_1"/>
    <dbReference type="InParanoid" id="B7FQU9"/>
    <dbReference type="OrthoDB" id="187748at2759"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855209" evidence="2">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="31782" checksum="940C693B0DFA33A5" modified="2009-02-10" version="1">MTMHLLSLVFVCALVLPSVAFSTRGKAVRLMIRDPTSSRIEAHRSVGDVDVPTVQPIITDRRRLLIEASGIALSGWILGQPLPVRAVEPLASPRTIVVTGANSGIGLEACKRLADQGLRIVLACRTLQKARDTAELLRDKPGQLIPAECDLADTRSMQAFATDLPKLIGSQSKLDTVCLNAGLARNTAAKDVARTADGFELTVGTNHFGHFYLNHLLLPMLQTDARIVVTASGVHDPESPGGAQGTPATLGALQGLETDGRACTMIDGGSFNPDKAYKDSKVWMDCGSALWSTDAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR04</accession>
    <name>B7FR04_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176959.1">
        <property type="nucleotide sequence ID" value="XM_002176923.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FR04"/>
    <dbReference type="PaxDb" id="2850-Phatr32379"/>
    <dbReference type="GeneID" id="7196944"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32379"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248118_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR04"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="872"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1606" mass="175420" checksum="ADFA049D8CE43D88" modified="2009-02-10" version="1">MSVETETSHIPESSISNATNAKGVTVEKQVVKEAKEKTIPSSGDGINDSITAGKSCSSQIRTWFESLSADELSAVMSFSDKAFLETFLDLSSWSDSDRVPYLREKHGSPSDVGSRQIQWEKLVPWKAVETSLSMCKLWVEEVENDSALSMPSASKTETEGPADASLSLAESEGTGRVAEEIGEIFLEESSSILEVEDECVGGEGIIDIQPFLSLLDRTCVIYSSAIRYVSEREREGKESPFVTVHPSHFEALQGSQLLSVLDTAASSMSEPFFLSKSVYDKAPWQHRFGTKKALKFPLWGLFLARFEKSVYNAFSKHTRQKSFHANEALNADFPLRDVFSHARLLGEKIVEIDVKTLEKVMLPLHLVYFGEDRPRSCTLENLMFLPLNWLVYAKSTCRKVNFLSGDVAVQCCLERVKEHSGLENVSFGNVGAEFEVTTPREGGQSQGTVLKKRRRRRVNRKKNSNETSIGPIGGEKRLTTVETECAPVETPLTELSTSLEAAVVPKGLVCELSVATDEISAQSDRSAVKQAEQSNVDDGSREITISRVQGTYVVASTPNMENIEQVNLSDDRKGDDGDSWEKVEVRGRANRKKAFERPHHGQLRGSHRGCASHSMHGHIDGSKKAKISRSSGARRRNTNRKVARDILYKVLDSVEDQVKNRGEEKPPLPSSNPWKTVHSVGRTPGVSTPCSQKGAQKHVTMRDVVLGKSVRKSTIKSSLSSFEASPSGTNALKESMKVQNSLVSSQQRMVDQNTAPTYQETVSAVSGNTHDLLPQKTSIFKTKKHDPKSDCISDNSEAPQNRAGETSPSNEKNIALSPPLPTLLNPESGNSSTSSVSSSLEVPHASHCHHHSTTAVDVNDVGYHLLDVCDRLSQDMRLFMSRRSQALNARRKERVALLGALQNSVAKLWPASCQVELYGSCATHLDLPSSDLDVVVVGLDRRRGTLMQVGTQNNGCLDGKMESKSDFDVDDVRQKILNASLPPYIPTSTSLNAERIKRLAAELATQPWAVQVKAIPTASVPVVKVLADPYRLQNVSGNDWKLDKHPKIAAETSKVSQVSSDSARLQSFQPWRGADAMNGLLSFDITFEGPEHGGIGSTEFSIRTVNEACRETGLPPEGTPFVQVIMVLKELLAQRKLNEPYSGGLSSYALLLLVVSLLRERTVIREELDRVEQQRQAVAADTMDTQFSRMGHDRTAPACPKSQQVTKTSNIQRMKKVAEGDIGKQQVSSTWASIAKSEANDSDLATNKVSGIWNSRQKRHSSFADVMLRPASQCKASNRSSTHMNDVAQNFDALHEATSECEKDGTGNREHMPDVLPADSSHVPTAPSFFQQGYNDVVDVLCSGNTTAGKLLMHFLLFYGHHFEAQKTAIDVSGTHARDITGRYLSYFSPFIPRGALGSIDPMTGMLTVDPVIVYDPLEGAENNNVARRCFAWNSIRWIFAQSYATLSSAVERSTNPPTCPNNGATPTPVADMTVLADSSRGFIDRAEGCVSVGVSKRRREKISGRSSTGRSSATSSASVTGRGGGSAGQGRGKTAGQGPKRKADASVSTVTGASTPTYHTETAATQTKCFLKRIDGTHSGNGRVRSYGGSSVRRSFQSLQISQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR74</accession>
    <name>B7FR74_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_6093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
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    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC51997.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16687" checksum="83BD97246E730982" modified="2009-02-10" version="1" fragment="single">KFTRCKPLREQGKGWGLVPCDKIGKGDLVLEYVGNVIDAKEKEDRLSEWERDHPNDPNFYIMSLRDQWYIDARHKANLSRFINHSCAPNCFLTQINVNGYARNGIFAKRDIQAGEFLSYDYHFDTKQGDRFVCRCGAKSCRGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM5</accession>
    <name>B7FSM5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43556</name>
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    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002177971.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="7197295"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43556"/>
    <dbReference type="eggNOG" id="ENOG502QVHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="B7FSM5"/>
    <dbReference type="OMA" id="HAMACLV"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TPM_dom"/>
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        <property type="entry name" value="THYLAKOID LUMENAL 15.0 KDA PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35514:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 15.0 KDA PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852628" description="TPM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="27297" checksum="E1A82676BECCFBB8" modified="2009-02-10" version="1">MRNLLSALLLLLNHYAPVVAFAPSANSRDTLRARTHTGLGVQPDEFTPQGEVTRRSAFSTAISRALAVGTVAAGTTLPAWARLESVDRPDLLPAEKGVNVIQTEKFLTSGQAKRMNDLLVALERDTGFRVRVLCQSYPNTPGLAIRDYWDLGKEGQKDDKYVVLVVDQFGGRGNVLNFNVGDGLKFALPNVFWNRLSSKYGTTFYVRDNGIDLAVTNAIEAIVTCLRSEDQYCVSVPEEAPSMKSLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSR9</accession>
    <name>B7FSR9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177714.1">
        <property type="nucleotide sequence ID" value="XM_002177678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSR9"/>
    <dbReference type="PaxDb" id="2850-Phatr32833"/>
    <dbReference type="GeneID" id="7197468"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32833"/>
    <dbReference type="eggNOG" id="ENOG502T9U5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736645_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSR9"/>
    <dbReference type="OrthoDB" id="38408at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="185"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="376" mass="42468" checksum="BCE79E02F091C0C8" modified="2009-02-10" version="1">MTASQYVTLISFSPHVRYLCLLSLSWLSVTSHGFALSHNTLKRFAPNKALCSPPTRLDLISLVNFRDEITFFDKTDDERCCINRQGEFRPQKGDVFELALAEETDLPDVSRFIVTSFGADAIRVSQDMSTFEGMLMRPAVELVNGYSGIVAFAEVLAGLRSRLKTRIANGSDLSLPELKGRSRTEQISEATNDSIVLVLGRRHAGNDWHIDVIASVELRLQLCDAKIPFSLPWLDRIERTAASWIGLGKNHARDLQPYLGNLCVAERYRGRGIGRALVRCVEDISKTKWGYSRIYLHVDKDNAAALNLYQEEGYRDVGLRWKPFWAGKAVDIGYYVKGLNRKERKEYKASLSIDKKENKSDANTVEGKLKRSDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT01</accession>
    <name>B7FT01_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177752.1">
        <property type="nucleotide sequence ID" value="XM_002177716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT01"/>
    <dbReference type="PaxDb" id="2850-Phatr43650"/>
    <dbReference type="GeneID" id="7197361"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43650"/>
    <dbReference type="eggNOG" id="ENOG502SUCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1206912_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT01"/>
    <dbReference type="OrthoDB" id="45725at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="302" mass="33924" checksum="B03500260338C677" modified="2009-02-10" version="1">MKPTNRTPGLQTIPRDEKTVTATRVQFCRYVMGHHVCLLLLLYISCLCRDRLTCVAFTPGTYFSKLQSSGCRQLSIRRHCLLVDMQTSRGASSGNQNEKDHGNWLERAHQLRREAQDLESQLRPSGEAVQRPPIRTKSVQYTTLAASYWTFTYRFTSVPLSADDDSGPPPDSFGGKMTLHFRSDGFTELISHEGLSGKPLEIIKVWGWDLETSSEDEEEYLLFSVDTVLPSPGLEQRFYFQARQDLNNDGTIKLTEGTVTMKQDVASASSNGFWGFMSPKGILAEFRYVGNFVAKPSPNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT46</accession>
    <name>B7FT46_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177775.1">
        <property type="nucleotide sequence ID" value="XM_002177739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT46"/>
    <dbReference type="PaxDb" id="2850-Phatr32960"/>
    <dbReference type="GeneID" id="7196991"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32960"/>
    <dbReference type="HOGENOM" id="CLU_1009943_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT46"/>
    <dbReference type="OrthoDB" id="45004at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854983" evidence="1">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="30754" checksum="35B1A7310D93A67D" modified="2009-02-10" version="1">MRRVSALSICSFCFLVYSEGFTGILSRDAVAQCRLPLFATRDQSSLTFRCDIQYTSEVLPECGKEEAAAFLFRPETRDLLLSAGGSRLVKEVLVTPEIKGMWVEACQRYYSQEDFPEKGDKVMVVGTEIKFPGLKLMIKALSGVKAYSTDDGLYIYKFYSIAEKQQVEGALPVVWLFNQITGAKDKPNGFGPSNAWSKTCVSIVELGAGTAYNFDCTFEIKMQFPATLLRLLPASKEMVEEQSSITIRNTLFKDIVKAVDASHKAFSQRCDSTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTJ1</accession>
    <name>B7FTJ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178424.1">
        <property type="nucleotide sequence ID" value="XM_002178388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTJ1"/>
    <dbReference type="PaxDb" id="2850-Phatr44270"/>
    <dbReference type="GeneID" id="7197946"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44270"/>
    <dbReference type="eggNOG" id="ENOG502SHTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030622_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTJ1"/>
    <dbReference type="OrthoDB" id="40564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852676" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="302"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="628" mass="71062" checksum="53FB83EE533A87F3" modified="2009-02-10" version="1">MKNTWSSLLFISLLSCSVDGESQSGLIEKQILTKESKPLECGLYLAPSTIPGAGLGLFVGHQAWEEGTKAGYGDICIPIVNPHLHRNYSKPFFHPLGDYTWSHIDVGMTLEAYPALHLEAFCPGIDALVNSHQFVLNLGSPNKSHVAQYLPAGIFRTSPNAGAVSPYRNSTTRVSRRIPPGGELFKSYGPTWFPSRAKALGDSFAFPEDFRRGQALLNRMAPLVDRISSTVSVSPLFTDLFDIVQAVTGTFQSRILKTLPREPQHAHDAGDDESGLLRFHEDMSRHSLEYLTSYGQCVDHVRPVPLSPKHPEAGQGAVAARDLPQGTIVSTSPLHVFPDLDYFNMYVLKQNDKGTWERESDHVHTKQLLLNYCFGHPNTTMTLCPYGPGVNYINHDRNPNVRIRWSLNPWHNATAVAERTVENSFDFQLKLAFDYVALRNISEGEEILLDYGDAWETAWQEHKRTYQPIDGKIIQPDYVYNHQLHIPLRTRSEQEFDPYPEHLHTRCHVALLQPTYRQSQYNWLETPESPLLVNYGLPCHVLQRYASEMDPSEYAYTVELDLEILSDEHKADLSIPKNDLVLERHQVPRRGVAQFTRPNLSDMHLSNTFRHSIGLPDSVLPLQWKNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTL7</accession>
    <name>B7FTL7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178436.1">
        <property type="nucleotide sequence ID" value="XM_002178400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTL7"/>
    <dbReference type="PaxDb" id="2850-Phatr44294"/>
    <dbReference type="GeneID" id="7198008"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44294"/>
    <dbReference type="HOGENOM" id="CLU_1013593_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTL7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="275" mass="31793" checksum="DB9EF52F7FDE3968" modified="2009-02-10" version="1">MENDRKQYWLKEQEKIPNTLRKYWNPNLLRKNTKETLEESIQPQTSVEKKRNCVSKTSEDSMAICDRPSKTNAKCQSESILLPREKMLLLLEQRIRIKLKSAEKDVKTTAKAVEHLLFKTASTPKVYEDLETLDKRLYAILAALMKRKVRKISREQDRTVILKHRLGIKTFEAVQVILREIQLLRLGRVALGCNKLSCNSQTKKDLLSWPVSKVDLPKGEKLPQAVKNIFFKNELTKAWQTTQAVSLANHNWEELVASTEKDIEAYKSWASASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU26</accession>
    <name>B7FU26_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178241.1">
        <property type="nucleotide sequence ID" value="XM_002178205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU26"/>
    <dbReference type="PaxDb" id="2850-Phatr44428"/>
    <dbReference type="GeneID" id="7197883"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44428"/>
    <dbReference type="eggNOG" id="ENOG502SY9K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881285_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU26"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="32775" checksum="0020ADBD17DEEC15" modified="2009-02-10" version="1">MRHNPLRKAIQSVTPFSCRSDTDGRKACRSLARLPLHLLREASGVSELATRLFYFHVWSRAFGFLYRRKINARKILGRPDAGSFVKFFQPRSIKKFTRSCVSFDNSPDGSCVGWKLFERSRVSRLKKWDCEEHLLDCRLDFMILRRLLGTETSVPLKGSSWSYRRSSIPTGFAVVPRKSNGTGNGATEDCCSKCWSGLQKKQGNASSPTLCAPVNPMIAEESQPMELDTTPVVVEEVKPVVVDTPKKKKKASYKSMMKAMTKTDPERDVEKDKEALRKVTGGGAFTKIDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU38</accession>
    <name>B7FU38_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178250.1">
        <property type="nucleotide sequence ID" value="XM_002178214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU38"/>
    <dbReference type="STRING" id="556484.B7FU38"/>
    <dbReference type="PaxDb" id="2850-Phatr44438"/>
    <dbReference type="GeneID" id="7197678"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44438"/>
    <dbReference type="eggNOG" id="ENOG502QR9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597831_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU38"/>
    <dbReference type="OMA" id="ATIMPIR"/>
    <dbReference type="OrthoDB" id="361580at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF15">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="363"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="458" mass="51519" checksum="62CF87F710DAE4AB" modified="2009-02-10" version="1">MSVVQPTKRAKAAVGLILVLVIGSDGLDLSLRPHSKPSSVSYPCRFVVGPTRLAKPHRHPRLPMRGYRYPTVRGAGDSLSSEPSQNRPSWAWVWMPTWLFTMNPLAQFLTTMGFYLLHILVLSQRQLVFPIQLIPNEKGQFASIGYDSIAGILVAVCYTILRKASTQSSLQSSSEAPFPALFKSPTSDAPWKLPSNHIRHRVSSFLTIILLVQAYFFTGRFSLFWEDTLYTMSGLGWPLTAPMHRSLCVLFGHLSWLITGTLLLRFVPRPPRFFGPKAVYNTDDDDAVSSKSPAKPAYRWFRSSIRRNWVWWVVGGYFVSSWLFNITDVINQFVLPTAVLEDAQESVVSQLVNPEHNDIAASVAGYIAPCLTAPWWEEVLYRGFLLAGLSQLLGYPWAVFVQGLIFSAHHMSLTAALPLAVLGWTWAILYTKCRNLFTVIFVHALWNSRVFLGSWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU49</accession>
    <name>B7FU49_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_44445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178256.1">
        <property type="nucleotide sequence ID" value="XM_002178220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU49"/>
    <dbReference type="STRING" id="556484.B7FU49"/>
    <dbReference type="PaxDb" id="2850-Phatr44445"/>
    <dbReference type="GeneID" id="7197739"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44445"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009091_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU49"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09213">
        <property type="entry name" value="Luminal_IRE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852692" description="Protein kinase domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="526"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC49921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129092" checksum="41F3CDDC802AA3CB" modified="2009-02-10" version="1">MNRRQRRGVVWAVLVLPLFLSLGRSVFGAHKSSRTEAGAEASTTESLFVLCTADGTIYSIDAWTGEFQSVVLTGSPLISHHQHAARDEHAESSHSMMVPGLDGTLYWKEDGGALQALPLTMESILEHPVRSCDPEDQHCGILTATAHTSLIALDEWGKLAWKTIPGSTDDPLQAPTTSSNADENTTPRPNEEQAQASSVLLQRKDYWIQHISSETGRQVWNATLGMYQALEFDADEQDEEGRLLPGASTSRHSGATHFPGVVFSNAGRTLAGVDLQTQSILWQIDTPTVLATVFGMHAGQWKPVHVLQSHPLESETMPKVVQQRALPDRASPVTQYVDYAELWRQHQSSAEQTHRWCPRTTCLPNQPCECSEFNDDTCVDTEPSRLELPSPTSAVPMLVSQVDGLLLSWRVVSLIVGSLLGLVVCGQFWYIRKKEKWSQATKTSRSRSSSFATNSHEDQVDGPMIGMKRTMSLPAILKPENSTALPTQSSVDIVPSAPAYSSPAPSSKDASGSIPLVRYSRYASEFQELRALGKGGFGTVFQCQNSLDGRDYAIKKILIRGNDLNFQTRLERVLREVKILAVLDHPHIVRYYTAWLELEESNHDESLNVDDDETLSRKFSSSLLTEQTDWNAHKTGHNKSPRPRTQGLIMGGEENGWRDDFGLSEEPSFIVRRTFHREISDCGFIFENSNETGTGTSPDEVTANQDTEAVEDVCSHHQDLKSLDKIADPVVTGDLPRSPSSSSDISASVVIAPELAKALKKSSDPPLRTVRHILYIQMQLCSQETVNDFLTDANARKGVAPEGVDVPSALKLFFQIAQAVQHVHGRGLIHRDLKPSNCFIDGSGNVKVGDFGLSRESTDKDEGEASFPQSRQEDRVFDNHTAGIGTRSYASPEQMNGSDYDSSTDVYSLGIILFELCYPMYTGMERNICLSQLRCLRFPETWHATVGRGFPTLQNLIKSMLSPNPNERPTAGVVAQHIQSILGEFTIQSLDLQDAPGTILLRVEAEHRDDVLRYTMQCIQNVAEEDDAAEGKIEIVQYGLRSSNRNKDKPTAVMEFALRSSLPGTMFVEYLRKRPEKSRNLEQGEFWFFAPNEEEQQAFFWVCVRQFSLHCKFPKIGSVTQFIFTKSAAQPLDLQLSTSKSAARHMMRCTNEDGFAWGGEPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUB0</accession>
    <name>B7FUB0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_44493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178290.1">
        <property type="nucleotide sequence ID" value="XM_002178254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUB0"/>
    <dbReference type="STRING" id="556484.B7FUB0"/>
    <dbReference type="PaxDb" id="2850-Phatr44493"/>
    <dbReference type="GeneID" id="7197718"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44493"/>
    <dbReference type="eggNOG" id="ENOG502RK0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267896_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUB0"/>
    <dbReference type="OMA" id="WYNEGGF"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1247" mass="138262" checksum="1B7714D73F87226A" modified="2009-02-10" version="1">MSVNVKTVSQAEPTTSPKSEPPITSFTLKVSAKDAARFFAMSKAINERLPEVSPDTGDTCEFSLHAQLYEATQKCPDELVKGFLDRMIAFLIPVKEIKAGLVLLHDANMNDKLLHVAEALSPSATTSGLDKGQLTSLFRSLLTAISCCIDQSTEAVDLEDTLMEDKPQGLEPPPKKTKLDIKIVEESDQEFRPCQSPSFDCSLATLRDEDDTATNTVRREIDEISSFAAGEVLSDGVERATFDLLRSWYDEKGKSVVPWLELLDATKWMSTEPPSPPCRKTAECDPSMETHQALRDDILQVDENERSVSSGSRDIRCSVEEELPVPPTAAHSPIDSLSDGDGSRILVSFDFSGTGHTTPLCINVSENNIVALRQLVHRTGIVHCQAVEMCRRLLHMASQRQEGNETILALHCHDFSRSIDQLWSPEVLKNISKEERESFTLSLTSILSCYQETKPSLSSEEVDLQEFAVGFCFFCAGNKSAKLATGFEMLDDTRHGYLTEQQLLRYLSSYLMMLSAISLLHPLSKGHHSNKLTPQRRKAMRTAVDNGAKWTIGHFLKHMHDREGGEHPNAYSFESFALWYSVGGYNVAPWLELLDLNKLFVLIAPDVESSLHTKSSASMAHTSGGRRPAGQRDRMSTLRRHHSRRNPGTHPEVLFTFPLARSRSLVVLKEDARYVRDVVQELGLLSFSPDFVWSSLSKIVTRPSTPTEGYGVDMQTFVQCMIDVCNKSSRKRSASGAESTMEELLCNFYQCFNLDQKKLVAVDELMGGLTLLCGGKKSVKLAFAFGIFDTRPGVHGKSAESVVHSLDGHDLFVFLRSILIVAFSCCRQSLDMDDSVVGQCISDTANMLCNDVMTHQGKQRFCDRLNFDEFGLWYNEGGFERAPWLELLDLKKWVLADNFDATLEKRVVESQLQVIPVSIATDSSIPPPPPEDALDGSFFEENGIMAMDSMDEMDMILMQSSTDRESDQRSPAYGPLPESSSHSPGSKLCSPDPRGNPLKFHLLTNEEQGGYNVSLSHIRITHLKSVLEDNCLHGLDCENVCNAILNKATKKNKAISKKGFDAAVASVMGSQRGRPETQQVLSNLLSGIFDAFDRLGSGTPSAVEIACGFTVLCHGKKSDKLEFAFEVLDTKKKGKLSRSDILTYLRSFLTVLMSIAFSPALKKDIRDDKISTMKGFGCNQTTAAVKHAVNAGAEWAVTAAFDGKREGDMSVMSFNEFADWYTTVGYSSIPWLELLDLQKWVFTNDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUE2</accession>
    <name>B7FUE2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178579.1">
        <property type="nucleotide sequence ID" value="XM_002178543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUE2"/>
    <dbReference type="STRING" id="556484.B7FUE2"/>
    <dbReference type="PaxDb" id="2850-Phatr44521"/>
    <dbReference type="GeneID" id="7197735"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44521"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269070_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUE2"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="218" mass="24618" checksum="45D789BB98D330AD" modified="2009-02-10" version="1">MGDKDEVPAGTSWRQTLLTSDEVYLYTVPTLKTSSGHRAEDWNLANPIQTCKLLVERRGDSLALEFRHDEKLFAQATIDLTIRKEVQIHKWLESTVDSSRYFVVKIQGSGGREALVGFGFRDRDVATDLRESLQHYENSIRRQRKAEDFTMSTTNSYSIPMLMEGEKIHFDGKSGKSTITRKVKDKGNSVPILVRKPPPAATGHNPPAPKERGTTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUI2</accession>
    <name>B7FUI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178599.1">
        <property type="nucleotide sequence ID" value="XM_002178563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUI2"/>
    <dbReference type="STRING" id="556484.B7FUI2"/>
    <dbReference type="PaxDb" id="2850-Phatr44561"/>
    <dbReference type="GeneID" id="7198081"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44561"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599177_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUI2"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48875" checksum="0A554AF3A0E227A0" modified="2009-02-10" version="1" fragment="single">MSTKELFGDSSSDDDDDVADNANPPQAAPPVSERATSPRLSTPTHTTDAHNALDDSDNDEGDVEFDDRGTVVGLSSTTIAGDQINTPTRNTTDPDQAGTQARDNDEDAPTDAGPRIAASQLYLQQEPKISENIALHMTKLPNLVGIQTQAFDPDTYHPAMEEDDFGQSVYNLVRWRYRKDDTGNYVRDEQDRLLRESNSRLVQWEDGSYTLHIGNEAFEIDALKTAANGFPGLNGFIYRTQKAVLKTADDNERAAGTVLECVGAVATRMTIRPSSLQSEAHKSLTVGIRQKTMKKARIAEYVTQEDPEKAKQDRIKVKQDLEKVSARKRSGYSQAGGRTARPRMSRSYLEEEEDGDYDTFNIKDTKRRIRDADEELKEYGDDDDSSSEDDEYDQTFSKRSNMRGASTAAATAQPKKESDEEIVVDDEEEDDDEDMDSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUR1</accession>
    <name>B7FUR1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonyl reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178364.1">
        <property type="nucleotide sequence ID" value="XM_002178328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUR1"/>
    <dbReference type="STRING" id="556484.B7FUR1"/>
    <dbReference type="PaxDb" id="2850-Phatr44630"/>
    <dbReference type="GeneID" id="7198118"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44630"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="B7FUR1"/>
    <dbReference type="OMA" id="QKKFRCE"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29727" checksum="C7BB4E00FE6574B4" modified="2009-02-10" version="1">MMSTVSGRVAVVTGSNKGIGYFIALQLGLSNLFEHVLLACRDESRAADAVASLQAQLPNKVKVSSASLTLGNTESHRAFAKQMEESFGKVDVLVNNAGFAFKGSDSTPFKEQCTPTLDINFRGTVDLTNRLLPLIEKGTDPRVVNVASMAGRLAQLSPELQSKFSSNDLTMAELESLVDQFETAVHDGTQKDKGWGSSNYGISKLAVIAATKVWAREYANKGTVSINCCCPGYCKTDMTSAKGVRDPADGAKNAVIPATMENPPTGQFFENFKVGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUV4</accession>
    <name>B7FUV4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_34147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178662.1">
        <property type="nucleotide sequence ID" value="XM_002178626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUV4"/>
    <dbReference type="PaxDb" id="2850-Phatr34147"/>
    <dbReference type="GeneID" id="7197909"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34147"/>
    <dbReference type="eggNOG" id="ENOG502SG09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461921_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUV4"/>
    <dbReference type="OMA" id="TISACYV"/>
    <dbReference type="OrthoDB" id="194491at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051337">
        <property type="entry name" value="OPA_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="591" mass="64654" checksum="709C80ED9FF2939D" modified="2009-02-10" version="1">MTLPPLSSLWTTNTLFGETQQLSARRQYQPQHQDRDDNHDGLDFSRNERLRDDPDVHIGKRHSLNKINQFLFGFMYEDENEEDDDDVLYRSTVEPSTPLWNRLNLSLFGILWLLSTAEIIPVTLVVSMCDNFVEVSDGTWTSDATTIPSTTATSAAARLAAAAVLGTSMGKLINGPLTDVWGARRSLCVASGAMAVGLVLLATAMTLDTAAMACFLVEYAYAITWPCCVVILATHYRGNASGMYEGGIYVTSLASRLGALTGIPLASVLLRHTTEATTTTTTMVGSSWRLVALLAAWIALVASSVVYFYVADTPSRKHQPQNPLDPVWLNKWFPSYANGSRPLTLSTTLRLIPFVVRYNLVPSMKHVLRSGTFWMVALAHTGSSMVRTSERLIGTYLSDTSNDSLSHNRAGGLAVFLSLGTVIGLLVAGNLFATLHERARKRLVTRLYILTISACYVLALLAIPAVRNTWQAPELVTTFQVMAVAVAGFGIAVQFYHIPGLVGATFGCDKGLFAAYVDGVAYLFASYVWRLVIGKAVQDPVDDDGLGWAYGWAAVALLLILSAVLMVEFMEHYFCRSLHQQGGTYETIIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV19</accession>
    <name>B7FV19_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179066.1">
        <property type="nucleotide sequence ID" value="XM_002179030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV19"/>
    <dbReference type="PaxDb" id="2850-Phatr34514"/>
    <dbReference type="GeneID" id="7199487"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34514"/>
    <dbReference type="HOGENOM" id="CLU_964618_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV19"/>
    <dbReference type="OrthoDB" id="47440at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042023">
        <property type="term" value="P:DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033246">
        <property type="entry name" value="BIN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="289" mass="31716" checksum="0289C0EA410113F9" modified="2009-02-10" version="1">MSDDDKSFNPNEDVEPTIQPPKTKKRPLHSNADASSASRKENSRTLAIKRREQTSSKSVATVNDLGAGIMNSELRNVVSEHNSGKPPSAKRLPATKVTKNIKKTPQNVEPIKSCIPVEGVLHAECDDKFFDNYDVVIPPNFGSNGEYTLLVQIDPEDSASLDFTGAVGAIGRLETVAEGVVLDFKGCQYRGRIYPGSTAVVLSTNGKKADTQLLKVESMTDEFCRLTKEGNAMEKLNAIVRGDMVGYQYQFREDDVNRNTTVQTIESSEPTSKKKQLTSTTGGSQKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVA1</accession>
    <name>B7FVA1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_45011</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178890.1">
        <property type="nucleotide sequence ID" value="XM_002178854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVA1"/>
    <dbReference type="STRING" id="556484.B7FVA1"/>
    <dbReference type="PaxDb" id="2850-Phatr45011"/>
    <dbReference type="GeneID" id="7199525"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45011"/>
    <dbReference type="HOGENOM" id="CLU_736649_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVA1"/>
    <dbReference type="OrthoDB" id="49515at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF13-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768:SF18">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL47-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="376" mass="41793" checksum="0F1E20DB86B92035" modified="2009-02-10" version="1">MSTAQFIASRLLREALQAAIANDADEDSEATFFPTSAPTTEDDFQRRNWMMYNIAMVKKPLLTGVGVLIGLVMIAYGFMHLLERLNVCERVDMQRAERKKSDGLWDIQESERRKILLFLFRKQAKTVFRFKREEGGKAVVDETTTQPLSQQSTMPEDANRDICVSLNQESTGTTINGRQASCCISGSVIQKSAIPPDTTDCGQVSTADESENVTTSEKNVSHPLNGSSTKASPDAVLYDQEQKETVASILVAPNEELDSSTNAADDENDNNLSYEEVISEPSTDSLEYVCSICLSDYEDGCKVMTGTACQHVFHMECAMEWLQKHSHCPYCREPMMSRDEFRLAAMQVLGLVRCRELGILADPSTDTERGESDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVI8</accession>
    <name>B7FVI8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_44756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178938.1">
        <property type="nucleotide sequence ID" value="XM_002178902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVI8"/>
    <dbReference type="PaxDb" id="2850-Phatr44756"/>
    <dbReference type="GeneID" id="7199877"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44756"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="InParanoid" id="B7FVI8"/>
    <dbReference type="OMA" id="AQNDHIK"/>
    <dbReference type="OrthoDB" id="185936at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="641" mass="71419" checksum="5B90B2A10D649BCE" modified="2009-02-10" version="1">MTDNEYDKAEENEPVTMEEPGAITQPNARNPRRLHSAQSSGMESSVLRFNLNFTVGSKGKQKAILSDVAATVKWGHVLAIMGPSGAGKSVLISALTLDALFGRTEGRVTLNGVPLTDKIFKSHCYTVVQLDQHWPYLTCRETLRYAAELYDVAAKEDIDAVVDEIVQKMGLDVCVDTRNARLSGGQRRRLSLGIALLKQPTLLFLDEPTTGLDAASAENIMQEIVRVAKEENLIILCTIHQPSTKVYQGFDEVMVLSKGREAYTGNVKESVPYFESIGYPLPPQTNPAEHFLDMVNADFSDDAEVDRILDTWQEKRPGAGSSHHKKGFGGVDNDDEGQEGVADVKRALLRKEISIMFSRHLKLMMRDPVLYSGRAVIFFVVTLLFSLVYLNARDYSQDQALNKMWIVLWLVSVPSNMGVVAVYALNEEFKSILRESKNGMASPLSYALAKTVLVIPIMFVFALFALVIASFVVIDMPWDTFGVAIIIYAATMYVFECVAECLSVWFENPILGMLQFMNFWFGSFLFAGFLISKDDLFWPFTLFYYIMPYAYYLRSSMYNYLKDTTFDSCEPGTSAGVCVQSTSGSDVLGGINLVYNVVENEDTISADIATLIGIAIFYKILYIIGVVYKSSRVTTIHEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVZ9</accession>
    <name>B7FVZ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA family transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178796.1">
        <property type="nucleotide sequence ID" value="XM_002178760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVZ9"/>
    <dbReference type="STRING" id="556484.B7FVZ9"/>
    <dbReference type="PaxDb" id="2850-Phatr11230"/>
    <dbReference type="GeneID" id="7199587"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11230"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041968_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVZ9"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10283" checksum="08A54C54A713EDEB" modified="2009-02-10" version="1" fragment="single">RPMYDGIINALQKLQPGELRLVDNSQQHAGHAGAKGLDGDETHFDLYITSDAFDGLSLVKRHKLVYMMLGEIMPKIHALQIKALTLAEADAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW64</accession>
    <name>B7FW64_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ParB/Sulfiredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178828.1">
        <property type="nucleotide sequence ID" value="XM_002178792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW64"/>
    <dbReference type="STRING" id="556484.B7FW64"/>
    <dbReference type="PaxDb" id="2850-Phatr44938"/>
    <dbReference type="GeneID" id="7199839"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44938"/>
    <dbReference type="eggNOG" id="ENOG502S2UE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247366_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW64"/>
    <dbReference type="OrthoDB" id="204494at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855089" description="ParB/Sulfiredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="85062" checksum="E38480B3264F4E4F" modified="2009-02-10" version="1">MKRVRAALFQALALAVLLNVPTLEKVDAFILPFSASSLAARPVVSRPIPPTASHSSSVDDCGSGDATIFSGDPPQLAKEMDIRERIRAESFLRVNGEAELIVQWSRRIDELEQSGVRLVMVSIGKPEKGRQLIQHLEIPSGEDYLFVDPVNALYDAISLNRGVDRTFFNINTPLAFVERLTKEDGMKDLVNILGKWSKAFFIPPKNEQAFLQGGTFVFDGAKTLFAHYDPSTASHASVDNVLEIAYRKQSLAPANPTVSDAHFFDPRARSRKASAFDVNPHRASPMAFLFRQSVLDTLLPIARCTRVSVDTDIVMGLPMLAQLVERAVKHPTVSRAALFWPMSHRFLSSQRPKTTSTSLFDSASDFMHSLRVKATNALTATLSVQEREQLFSRLTPPQQEKQDGKTNDDRMDMEHSIAEAVAAARAQEAKKQEDKWSKTKEAIEKEAEKAARERVENEFKIQRRRIEFERWQTQVEEEKQRRSNKSKVEAAPGPVTRGEVVEQSVESEINVHPVLGAAIADFGHKRIHVVSAHALSTIPVWKKQRIYRHDRAKAMASDKMKTLHLGMPGIIGLHEDLNGKLSIIDGQHRVGMMTILHEKCASHDDFDLDRVLVEVYPQNPDHVDTHAQDLFLEVNKAEPVKLVDMPGVAKGSDRKIISEGAERIAEKYAEMFKSSQKCRPPHLNIDNLRDALFASNAIKRHNLKTSKAVEAWMLAKNQSLADLYKDPAEQEKVSKTAYEKAKKFEFYLGLDLSWLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX06</accession>
    <name>B7FX06_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_8239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179470.1">
        <property type="nucleotide sequence ID" value="XM_002179434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX06"/>
    <dbReference type="STRING" id="556484.B7FX06"/>
    <dbReference type="PaxDb" id="2850-Phatr8239"/>
    <dbReference type="GeneID" id="7200125"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8239"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_18_1_1"/>
    <dbReference type="InParanoid" id="B7FX06"/>
    <dbReference type="OMA" id="KEVQHAY"/>
    <dbReference type="OrthoDB" id="41702at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="66" mass="7778" checksum="2B8F61B7CB3479DC" modified="2009-02-10" version="1" fragment="single">YRVLNVSKDATKNEIRQSYRSLCLKYHPDKNVNRSGAEKRASEERFKQIQKAYALVGDIEARKQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX51</accession>
    <name>B7FX51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179492.1">
        <property type="nucleotide sequence ID" value="XM_002179456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX51"/>
    <dbReference type="STRING" id="556484.B7FX51"/>
    <dbReference type="PaxDb" id="2850-Phatr45285"/>
    <dbReference type="GeneID" id="7200148"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45285"/>
    <dbReference type="eggNOG" id="ENOG502QQM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382483_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX51"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="192"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="491"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="595" mass="66420" checksum="D009C3650B8A8E07" modified="2009-02-10" version="1">MAEDGARHEAMVEFLGTFTTLSSAPPETLTDLSDGVALFEALSEIAPDYFDPTTIARQLGDNWALKSSNLRKFLRNLEHYYHEGLGKDADFTLVNVSSIAKQSDVKSIDVLVELVMAAAVTCEEKGTYVARMMQMNANLAMKDILETSLARVSDFDAQDSDMDENELVFDGQEDADGMDERADDTNLFGANHLQQSEALDDARREISTLKSQAAMMAEDNEKSQGKLRALVEDLQDRLVSRQDQLIQVEEELQKATSDLEQTMSELGAMASVKTQLEDDLDVANAKAAQLYKAEATLMAYKKKMESVGAMNQQMTDLEDQAASYLRQIVDLENEVKKSASLEKTVTDLREEIARMEKKHTQVESRSTSSASEIAALKSRVEAAESARKLFEEELVDLRAQQEHALNSSVEAINLNESSAQAPNSSSAEHREKLTRLEIENETLQRKVQALEAAAAASIEIAEEAAKTSQRVSEVQKTPTTETMSAADIGKIRDLEDSLAKAMAKLELKEQENNKISSDKDKLEAYTKRTLAKFQDKYLVALQECKTKLKEKQDKIEILEQRSNSERTAQKREERLLSSTIFELGLAIMQNRLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXX4</accession>
    <name>B7FXX4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_12243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179840.1">
        <property type="nucleotide sequence ID" value="XM_002179804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXX4"/>
    <dbReference type="STRING" id="556484.B7FXX4"/>
    <dbReference type="PaxDb" id="2850-Phatr12243"/>
    <dbReference type="GeneID" id="7200590"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12243"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2163329_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXX4"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="16011" checksum="920B52945ABD7D37" modified="2009-02-10" version="1" fragment="single">FWHPQLQWSTEPGVARCVVGYSGGNEPDPTYQTIKDHTEAVLIEYNPDMISYEKILKLAKADYPYSPQKRQYRSGVFYLTEEQAKSAKEFVGKLSAKHSGERKLYVDIEPVTKFYRGEEYHQFFLEKQTSNRGLQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXZ7</accession>
    <name>B7FXZ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179649.1">
        <property type="nucleotide sequence ID" value="XM_002179613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXZ7"/>
    <dbReference type="PaxDb" id="2850-Phatr45527"/>
    <dbReference type="GeneID" id="7200724"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45527"/>
    <dbReference type="eggNOG" id="ENOG502T0X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_3_1_1"/>
    <dbReference type="InParanoid" id="B7FXZ7"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14310" checksum="040DD8A91C0C965A" modified="2009-02-10" version="1">MDETTRIPIVTKPASMMEVGPNGNNLASVAASRHPVDDLQRKLDVNPFQNLEYVRHVYGSGLAMRLATEQKVALEQERGAAGLPSSGLYRDIVTGNDVKLDFADFLSLPEYRPDVATISPHATMERRLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY55</accession>
    <name>B7FY55_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI inositol-deacylase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179680.1">
        <property type="nucleotide sequence ID" value="XM_002179644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY55"/>
    <dbReference type="STRING" id="556484.B7FY55"/>
    <dbReference type="PaxDb" id="2850-Phatr45579"/>
    <dbReference type="GeneID" id="7200363"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45579"/>
    <dbReference type="eggNOG" id="ENOG502S15P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757525_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY55"/>
    <dbReference type="OMA" id="CPAQFCV"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909:SF2">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855162" description="GPI inositol-deacylase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="4">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="366" mass="39793" checksum="DC35D92EC7A06996" modified="2009-02-10" version="1">MARVLRVAAAWWSLTAVNGFQSTVPQSTTRPIVHAPRTSDTVLGASLSSTPENKKNQPSTIQTPYNETGKLGKLERVALLVCPAQFCVPDDYAVLFENLRALSSDDAATLAWPRIGTCVVAPLPRTEWIRVARQLPTRAFWDARLPVHSTLDWYFDAIEKGLAQIFAQEGEDVRICIVGHSIGGWVARAYLGGLGRTSSAVYRLASTQVSSLITLGTPHVSPELALVDQTRGLLREIADAESCSPETLAARGIDVTCVCSQGLDGNFWTTNVEELVAASSYWPLSGSFRGAGDGIVPLSLAFMEEPSRRIVVESCGATMLPVRHSHVVPTPWNLWNGYAPSIILPDTTFPSYVSKGVVAQWAQYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYE3</accession>
    <name>B7FYE3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179723.1">
        <property type="nucleotide sequence ID" value="XM_002179687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYE3"/>
    <dbReference type="PaxDb" id="2850-Phatr35397"/>
    <dbReference type="GeneID" id="7200408"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35397"/>
    <dbReference type="eggNOG" id="ENOG502T9AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065914_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYE3"/>
    <dbReference type="OrthoDB" id="43681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38283" checksum="317776CE8AE62972" modified="2009-02-10" version="1">MGHAQPSRRSELRPSPSFALAKDRLAAYQARSNSMSERESSRTIPALALRAYHLPGNSWCDDWVQYFANNHPLFGICCHHRLHPVTAKWRLIHLVGSIVFGLAVTNIIWLWFIVNDQHDVNDPVLTISFGGGIRTGNSTVSTGNYTDTEYSNSTAEAALQGHQEIAVTEGMLILWTIGGGLHALFDNTVWYMTACVCCLPGQPLQCLYKYKWCGTYVVVLLVVIFTAVASFVVVLRASLEEDDMVDAGDLNSAGIVDDSIDLSNGIDRDREKYRFLLSYTVELLLALLVYYPVVGTILFTGILGCGRLPVLGGRPYEVECERKLQQRESRRSFNNGRKTSSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYT1</accession>
    <name>B7FYT1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ACL</name>
        <name evidence="29" type="ORF">PHATRDRAFT_54477</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="30">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180032.1">
        <property type="nucleotide sequence ID" value="XM_002179996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYT1"/>
    <dbReference type="STRING" id="556484.B7FYT1"/>
    <dbReference type="PaxDb" id="2850-Phatr54477"/>
    <dbReference type="GeneID" id="7201075"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54477"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_1_0_1"/>
    <dbReference type="InParanoid" id="B7FYT1"/>
    <dbReference type="OMA" id="MDYAWAK"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="29" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23 29" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="249"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="482"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="646"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EEC48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119428" checksum="03D6088760ED6657" modified="2009-02-10" version="1">MSAKAVREFHGKKLIARHVHEVSEGKHSIDDRSVLITTETDLETLPISETWLSDTLLVVKPDQLIKRRGKAGLVGIKLNWQGVQEWVNARMQKEIQIEHATGTLDHFIVEPFVPHEQSDEYYICIQSDREGEEILFCAEGGVDVGDVDTKAKRLHVAIDDDYLTPDRILEADLLEGVPADRQDSLASFVLTLFTVYRKLNFVYMEINPIVYTAEGTIVPLDLAAKIDETAAFLNAPDWGHLDFPAPFGRKEFPEEAYIRDLDAKTGASLKLTILNHAGRVWTMVAGGGASVVYADTISDLGFGHELANYGEYSGAPSTEHTFEYAKTLISLMTREKDPRGKIFIIGGGIANFTDVAATFTGLIKAIKAFQEILKAHHIKIWVRRAGPNYQEGLRLMRDCGAETGLDIHIYGPETHATAVVPLALGLAKAGDFPEFDDPRVHETLPKRNSSKASLEELSKIEYTGQVADHEADHNVENFTALTRCVVYGMQHRAVQGMLDFDFMCKRKKPSVAAMIFPFSANHFVKFYWGTDEIMMPVYQTMEEAFKKHAEVTVVVNFASFRSVYSSVLEMLNFSEQIKTIAIIAEGVPESQTRAINIAAQKLNVGIIGPATVGGIKPGCFRIGNTGGMLDNIVMSKLYRPGSVAYVSKSGGLSNELNNLICRNSDGVYEGVAIGGDRYPGSRFMDHLLRYNDNPHVHILVLLGEVGGVDEYEICGALKSGRISKPLVAWCIGTCASIFPFEVQFGHAGALARGDMETARAKNKALKEAGAHVPENFFEFGDVIHEVFEFLVNRGSLVPAPEPEPPKVPMDYAWAKRLGLVRKPAHFVSSISDDRGEELLYCGMPISEVFEKDLGVGGVVSLLWFRRQLPTFASKFIEMILMVTADHGPAVSGAHNTIVAARAGKDLVSSLASGLLTIGPRFGGALDEAAVMFKEASDAGYDAEQFVKNMRRSNKLIMGIGHRIKSLSNPDKRVEIIKNYALDHFSDNTVLKFALAVEQVTTRKKANLILNVDGCIAVCFVDMLRGCGAFSKEEADEMIHNGCLNGLFVLGRSIGFIGHYLDQKRLKQGLYRHPWDDISYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYW1</accession>
    <name>B7FYW1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_12322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180237.1">
        <property type="nucleotide sequence ID" value="XM_002180201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYW1"/>
    <dbReference type="STRING" id="556484.B7FYW1"/>
    <dbReference type="PaxDb" id="2850-Phatr12322"/>
    <dbReference type="GeneID" id="7201091"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12322"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYW1"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="212" mass="22829" checksum="0FD178B6E9CD3274" modified="2009-02-10" version="1" fragment="single">VLEAAQGSALVELGHTKVIGQVLGPVTASSSHLPPSLQLNMEEGVMHFELLSTGKINSWTIARETDLASNLSDALSASVPLRQYPKCALLVKITVLQDDGSILPACITAATLALADASVEMYDVVAASTVAVCDGLLVADPTLREVSAADAVMTLAILPNWKESTLWQQSGRLNPQRANEAMELCRNGCRTMHRFLREHLIQENEKDMAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ14</accession>
    <name>B7FZ14_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180077.1">
        <property type="nucleotide sequence ID" value="XM_002180041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ14"/>
    <dbReference type="STRING" id="556484.B7FZ14"/>
    <dbReference type="PaxDb" id="2850-Phatr45881"/>
    <dbReference type="GeneID" id="7200977"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45881"/>
    <dbReference type="eggNOG" id="ENOG502S9KP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_995584_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ14"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="206"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="31585" checksum="2BB4ADA9F61BE4FB" modified="2009-02-10" version="1">MSFQDFGRKNRGTGTPSSRPDPQAPASGYHRASTNHSHNALAQTSESLLQYQRHVGILEKIVQSLLARSNHPGGTAYDELELQYKAQLDVMNQWEDKLTRQIAQHRNTTNSSSNNNNNNKTVKSNHAATPPTAPTTTQWTKLQRDHERIQARVAALRDSVARRRPNGPPRRHLTDGESADSPSGHPAAPDYEQQQQLQLEQDRMNADIMREREEEIRNINRGMHQVNEIYKDLAHIVGSQQEQVDNIETQMEESRVNAESGLQQVEKANEKFGNANCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ50</accession>
    <name>B7FZ50_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180287.1">
        <property type="nucleotide sequence ID" value="XM_002180251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ50"/>
    <dbReference type="STRING" id="556484.B7FZ50"/>
    <dbReference type="PaxDb" id="2850-Phatr45913"/>
    <dbReference type="GeneID" id="7201002"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45913"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298192_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ50"/>
    <dbReference type="OrthoDB" id="203703at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052592">
        <property type="entry name" value="LRR-RLK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054:SF30">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110722" checksum="939D0466F4C48D6B" modified="2009-02-10" version="1">MIGMMDSEETETAESETIVINEAGSITPNVNGTLTDEDAGAQENAKGLPQTASTQCSGDPQSRAPVMLDAKGKSNTLPVQTQIYRTRIPAIASEADVFGSQRDTIDAREKAPRPFEYEIGMEEGSAAFALPSPLLCEGASRPGAFPMGLTRPLDDNEDLSAHSNLLQSESFLHTSSLLSMDESSGILVEASLVPDDSFIETSTTDNKPTALVQANPLPDTAFFFRPKIICTVLGTLIIIILALALGIVLSARSIDEGVSALNEGNLSASSSDAPTSANTLIELFPIEALPTYTQMSLQDPLSAQSRAVAWLKDDPLLASYSNSRRLQRFALATLYYSTRGEMWSTNDGWLSETDECTWFSDLGSASSICDAGIYRAISLVKNKLRGTIPQEMELLDSLVHLRMNFNFVFGPLVPQIANLIALEDLQLANAGLQGPFPMELASLTKCRKGFFHSNDFTGGLPSDLFASWTAVKDLDFGRNMFEGSIPVEIGAMVNIVSLGFDDNVFLSGELPSEFGLLTALEFLWLQGNSLTGTVPSSLGALTRLRELQIHNNFFTGALPEELCELVKKNNLIVVVDCFQVNCDCECECVESSRPLPSGLLSMPTLNPTMIPSSVNVISPTITSANRLQELRDNSLPEFTRLALGDPTSPQARAFSWLEQDPNVDDFSEKRLFHRFVLATLYESTNGEAWIRNDGWMTYTPECDWYFDTTWTASPTCLGDTFEYLVLEDNNLQGSLPLELGLLTGLKAIVLSQNFLSGEIPSTLGSISGLIELELSENNLEWFIPTELGLLTSLTVLNLQSNNLSGSIPREIGNMLKLEYLFLDTNILTGTLPMELGNLVNLLSIWIFRNDLDGSIPSSLADISRLEDLQIDRNLLNYSLPSPLWRALSRAAFINVADNLLSGTIPSQVGLLRQVVMIDFFDNLFSGTIPTEFGLLTNLEELSFVDNIFSGTIPTELGLLSNMRTLFLHDNYFHGSVPSELCNLVHSQSLDLSVDCNMVICTCNCECDLSFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ93</accession>
    <name>B7FZ93_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_12373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180111.1">
        <property type="nucleotide sequence ID" value="XM_002180075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ93"/>
    <dbReference type="STRING" id="556484.B7FZ93"/>
    <dbReference type="PaxDb" id="2850-Phatr12373"/>
    <dbReference type="GeneID" id="7201022"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12373"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_1"/>
    <dbReference type="InParanoid" id="B7FZ93"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23401" checksum="BEB0E84A41E2CA5F" modified="2009-02-10" version="1" fragment="single">AVVGTSSKFGATIIPRVAALLQVSPVTDIVQILAKDTFIRPMYAGNALAKVQTKEGFQVLSIRPTSFEKAPLQDTTVTVETIEVAEFTDSVWVGESVQQSDRPDLGSAAVVVSGGRGMQSGENFGLLEQLADKLGGGAVGASRAAVDAGMVPNDMQVGQTGKVVAPDLYLAVGISGAIQHLSGMRDSKTIVAINKDPDAPIFQVADYGLAQDLFEAVPELTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZM9</accession>
    <name>B7FZM9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
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    </reference>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC48365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002180138.1"/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="257" mass="28842" checksum="BDBCE01D0A859A84" modified="2009-02-10" version="1">MASPKPQTEELEVQWIESKWLQQQEGENTREADEEDIPAVGDLFADPDPLESFRFDWDTLEGKHIAIELTGHKAELGQTLNSTGLTLWRASELLCEYLVKHPEWVATKDVLELGSGLGLVGLLVHHLGAARTSLTDGDTDTLSNLRENVQRNGADTDCGRHVSCRQLVWGEKLESFQTSYGSFDTIVGSDIIYVEQILDPLWTTVDLLLRPAGTFLLSYARRNVSIDLVLRKATEYGFEWTTPEMSEGVFVFVRTSI</sequence>
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        <lineage>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
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            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180377.1">
        <property type="nucleotide sequence ID" value="XM_002180341.1"/>
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    <dbReference type="GeneID" id="7201308"/>
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    <dbReference type="HOGENOM" id="CLU_664762_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZX0"/>
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        <property type="component" value="Chromosome 9"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="262"/>
            <end position="285"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="414" mass="46702" checksum="6A8E7940A679C4AB" modified="2009-02-10" version="1">MAANKSNLVVFPDNLPTPQDMGWIDEDDETQATTAPPFFQDACAVHDDDDFSEESRLQHGQDLSQSERKFRRLRYALASLKLRRQKPFIENRALACRQDESTESSPTHCSQHPNEATCGWETHSETANVVVESKAGNDRWDRPFRRMRHRKPSKPKFHRDLLVDLDIDCGNHLQDVSLNTFFQQGHLESAKKKRDDILSFGEINAETRGTIMSGLAVDFDDGCAQLAIQPHPFEHGTDDDVRVNEWIRDDESLGVAFSHPAAGTSAVSPESTCKPRPPLPQWLESTNDSDWEWLESRQDEESVEVILSNVSPVMIKIESTHWENVGRSFSPDIFDDAMSEFNQASPTVKATPLHIPKKSDASRQSPLRVISALHGDFEAPYDESQEKSSFLVSSDYSPKRGDVRNSNILPVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0T8</accession>
    <name>B7G0T8_PHATC</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="4">eIF3a</shortName>
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        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 10</fullName>
        </alternativeName>
    </protein>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
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                <person name="Maumus F."/>
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                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
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                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
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                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
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                <person name="Jenkins B.D."/>
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                <person name="Jorgensen R.E."/>
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                <person name="Kroger N."/>
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                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
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                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Vyverman W."/>
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                <person name="Weissenbach J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
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    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
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    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit A family.</text>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="eIF3a PCI" evidence="6">
        <location>
            <begin position="12"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="815"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="931"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1022" mass="116824" checksum="5CD67FCD5D4B12C6" modified="2009-02-10" version="1">MATSNFFHKPELALRRAQELEGIHQDDAALAMLHEVLSSRRHRTWSPAFEQIMIVYVDLCLKLYKTREAKDGLHQYRNLSQTQAPGSLEKVIRYLLTAAEKKCTEAKASADAQQDQILEENGNGDDEDGFRASPQAILLSTMSTDPAKSQRDSALLVPSLKFLWETYRAVLDILRSNSKLEHVYHFAAQSALQFCQDYKRRMEFRNLCDMLRLHLGNLRQYGNLDANDDGKTNNKVRGWEGWTTESIELHLQTRFIQLETASVLHRYTEGFRTCEDIFNILQISQARRKHNPDVPAPKAKLMASYYEKLTTLFWVSENYLFHAFAWYKYYTLCKEFNRGMSEDTKRMQASAVLLAALCIPSVPANESKASHSNQHTIATTVEDGIVKQKMARMATLLGFHTRNPTRDALLAEIRSKGILEQAPAYLRELYELLEETNDPLIMVQKAKPLLEQLQQELGATTSNDVKNDDVDDTTLGRYVKPITNVLLLKLIRNLSAAYHTVSMDHLKSLTSGLDLSFEQVEKTIVTSSKTLAVRLDHRAGCLRFGNVQLESDAMRSQLVNLSKQLQAVSNVLTPPDRQSVLQSRLSTYQSVRENLHAEHAAVLERKNLIETRKEETERVAQEKSKQEARVKAEEEAARKAEEEQRIVREQRLREIEKQRKIQQELDNQEKKRFLAAMGKKTEDISEEQIAKIDTEALQREHEAKINKEREEAERKTRETAKKLDYLVRAIRIEELPLIKKKYEEKTKLDKERYEQENIEKAQKAKLQWEADVKDKAVLESHNVFAYCSEFENSVMVGRQAEHDVICQRAEEEAEMEAEKAKISRARKRKAAEEKLMAAEAAREAEEEARRKEEEEKRKKDEARREREAKEEERRRAEDERMEEERRKKAGPAKYIPPSQRLASGGERGGGGGEDRPSRFGGAGSYPGGGRYEGRSDDRGGGWRGGGDRSGDYRRGGDDRRGGDDRRGGDDRRGGDDRRGGDDRREGDDRRGGAYGGDRRGGAGSGSYNDRRGPPSDGNSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G174</accession>
    <name>B7G174_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180985.1">
        <property type="nucleotide sequence ID" value="XM_002180949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G174"/>
    <dbReference type="PaxDb" id="2850-Phatr36386"/>
    <dbReference type="GeneID" id="7201539"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36386"/>
    <dbReference type="eggNOG" id="ENOG502SSPR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1071410_0_0_1"/>
    <dbReference type="InParanoid" id="B7G174"/>
    <dbReference type="OrthoDB" id="49541at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28580" checksum="F2CD96B24A94CD76" modified="2009-02-10" version="1">MAPRVELPPSSANTPNTQSEEETRPNSSEKQDVTGNIIAEQQYQSMPRPDTAYGSSPALGPYEPISSSMYNSGGFGLGSGMYGVGAGYGGMGMYGSSYGMMSPGMGMGGPFNGLNQFLFGMQSVLFSLSQAIQIVSMNTQTFNQLFESATSMFDHAIETFHEMRSIESASRESESEEMKKRRRRLRALRWAIVTAVTIAGYKIIRRLARKRGRQEHPILMQNAFQPGGSMAQPYHGMSSHVQQRPYSDQWGGGMNGAQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G196</accession>
    <name>B7G196_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_1469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.28" evidence="8"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180815.1">
        <property type="nucleotide sequence ID" value="XM_002180779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G196"/>
    <dbReference type="STRING" id="556484.B7G196"/>
    <dbReference type="GeneID" id="7201550"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1469"/>
    <dbReference type="InParanoid" id="B7G196"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14133">
        <property type="entry name" value="PKc_DYRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="354" mass="40733" checksum="E3A92007FF3A6A89" modified="2009-02-10" version="1" fragment="single">DLEYFYLPIIFKSHVTGFEPTKDLFLEQGNIVAGQYLVEGELGSAAFSTAYRCTDLNSDQDSDGEHEEVCLKVIKNTKDFFDQSLDEIKILELLRQTGKCNENHLIEMKTFFYHREHLIIVTELLRQNLFEFGKFIIEDNEEPYFTMNRLAYITRQCLTALRFVHNLGLVHSDVKPENILLASYSRAQIKLIDFGSSCYLTDRQSSYIQSRSYRAPEVVLGLPYDGRIDIWSLGCVVAEMYTGEVTFQNDSIVSMLSRIEAICGAFPYHMIVQGRQSENFFTKRGLLFESLSEEEETNNDSHHSDKGEQNTLSKDLTRQAMFVDFVRKLLTIDPEVRPTAGQALEHPWMKYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1B3</accession>
    <name>B7G1B3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180825.1">
        <property type="nucleotide sequence ID" value="XM_002180789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1B3"/>
    <dbReference type="PaxDb" id="2850-Phatr36424"/>
    <dbReference type="GeneID" id="7201560"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36424"/>
    <dbReference type="HOGENOM" id="CLU_1039985_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1B3"/>
    <dbReference type="OrthoDB" id="196779at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="30609" checksum="27EA85FBA6B449C3" modified="2009-02-10" version="1">MHTAVGEKQLERQSTKIKMLEKTVRTLQNDKAILSAAVEARDSRLSSMTDLQMSLKEVESKLGIQEALQHKLKEAKMKCKSLRMQTKSAEENENVYQEKLAKHARKVLDLEGHVNLANDQRRSCQKELSMQQIAIQSLKQSVTVANKNAKVFPRKLARYVGMVEAYARRQEIVLLRDQKRKALEEMQYCRAACEQSRAAQKMAGLDNDMAKVLEQNLELERLLSELTKYVSAKEMQLETLKQVNDALKSELGSITKGRMTRNMGKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1E4</accession>
    <name>B7G1E4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180841.1">
        <property type="nucleotide sequence ID" value="XM_002180805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1E4"/>
    <dbReference type="PaxDb" id="2850-Phatr46488"/>
    <dbReference type="GeneID" id="7201823"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46488"/>
    <dbReference type="HOGENOM" id="CLU_1201860_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1E4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="231" mass="25816" checksum="8EBCF5F54F94369A" modified="2009-02-10" version="1">MADSDEDSTALSDDNTAKAGGEPRKVVTEDTCPETASKSARLEAPEATGRTQVRLPNTLLVLSPMERHASTQLKGTDLLETFLLRIILASLRCKKDYLSKKSKRKGRSVPAPQVQRTVCRSFGACPKLYCKIMSSYLMDHSVHTSGAEGQGRAGNPLPRETRIPRTKAVTIALREFVQKERMNRKRVTASQLLDFFMKENIVHILTDPRTGLLSKTEFDSAHRNVRRYLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G241</accession>
    <name>B7G241_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181146.1">
        <property type="nucleotide sequence ID" value="XM_002181110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G241"/>
    <dbReference type="PaxDb" id="2850-Phatr47001"/>
    <dbReference type="GeneID" id="7202235"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47001"/>
    <dbReference type="eggNOG" id="ENOG502S2C6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510454_0_0_1"/>
    <dbReference type="InParanoid" id="B7G241"/>
    <dbReference type="OrthoDB" id="46706at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="242"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="534" mass="58268" checksum="E1F7FD51BB5E72D3" modified="2009-02-10" version="1">MSHSVAGSSVDVSSSNSVASSGDASPTSGSRILNQSTPSSDASTVASVPSVEPQNPFEMSLNDTAVSASGAAEKTNQNTSSPARNGSNPPSPMHAHASHQTTRSHPSPVGTPVSTTPLREPHSPGYHQAQSSPPHAITGVGSLTVPTLSQSDQARSRIQQQLPGHLQTFPSPAQHGVREPVFDDDENTEPSSTNNTADQQHQEVGHGSSFIRFLENTRKRLSVANKDEDAEDPLEDEEGLDGALIYGYLQKMGRNGKWQTRWFESDGECLSYFKSKKRTKLLATLDLEKVGSICIDPQDPQGCSFTIQVLGRMYHLRANSKAATKDWVITLNRIKEAKMQQGHIHLVNPYEQQPQDLLDNHEEIVAPRVVVVANRERTRAVAETIDFDQLIRVDQNGENRELTYDNSKRRSTIGTVVLGRWTKRRSSLSRLSAKFSKWARSLKKYSCTESGTENVQLDRYVHPPGHDDIPKRRQPDSGPKLAADAESNPVSVSGWIGKETSRSGQAGSGSADVPQPTRAVRSMSQASDDVRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2C6</accession>
    <name>B7G2C6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_6626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181184.1">
        <property type="nucleotide sequence ID" value="XM_002181148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2C6"/>
    <dbReference type="STRING" id="556484.B7G2C6"/>
    <dbReference type="PaxDb" id="2850-Phatr6626"/>
    <dbReference type="GeneID" id="7201996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6626"/>
    <dbReference type="eggNOG" id="ENOG502S1FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932100_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2C6"/>
    <dbReference type="OrthoDB" id="197940at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021511">
        <property type="entry name" value="DUF3172"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11371">
        <property type="entry name" value="DUF3172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855743" description="DUF3172 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15122" checksum="200DFDD278403340" modified="2009-02-10" version="1" fragment="single">SVSKALLAGVFVLGVGLGVTIDSQVNTNPKDLASRDAIDNAAPNPTLCAKLGASAMAFDQRVFVSFNPFNVYVSQADVKPACVLREANVVPILKARGLINDNEVRSCKQNMNTWAFVGSLDDTPQLSCVYRSQDAQNEFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2I2</accession>
    <name>B7G2I2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181212.1">
        <property type="nucleotide sequence ID" value="XM_002181176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2I2"/>
    <dbReference type="PaxDb" id="2850-Phatr47110"/>
    <dbReference type="GeneID" id="7202024"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47110"/>
    <dbReference type="eggNOG" id="ENOG502RRC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320166_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2I2"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="907" mass="102832" checksum="4ACC7E6C170FB58A" modified="2009-02-10" version="1">MRTRNQRQDGADDIMSKVNATDSRHRRQDSNIKDNEQTPIVLPNRSIDGFTDDSFRVTQTRKRILRQGVAPQVAEGSGDCEQKEKSKTRGKISRLGAAGFYLKACHQSGYVLQAITWAKARPFVVGAMLFSIPFILRPSRFGRFLSFIGLMRWYPAYFGNHPIAGGPLGRKIDYNYLTKVYERTKRENQEKLGKLGITELPYIETLNAKEQINVLNLNTRAAIRELLVRRERRAVMWNELELQSQGLKLATDCKQCDGVAGCLNPCGIPRILLLPQLHNWEPPRPGLISGANLIPFTFDETEVRDFLSVAHPQLRNHTKQETNVSTTVWALAALTSYGGVFLGDQRRSKIDTANKVLFGGSNRGILDIALRDTPVAIVSLERTGTDFRLKMLMTTPNHPFLECALGELQAMSLLNVPQLWRMLMVSKEPSFYVDEGWKRALINCPAKKETGCCHSNSLVSVTDVAADYESQMLKVGKSVVYVQIVKEEILEVRSAKTAQVEIQHTSRASTEPSTKVRLETLLRLHKADPGWLCTRCIKTPWYGSMEKCSFFCPTRYEELVCRSPDKPPRREVPVDVNVLVPSQPSAQRIPRIIHQTWFEDLTIDRYPQLVRLQNSWKQSGWEYRFYDDAAAKEYVIENFPYHFAEAFDSLIPGAYKADFFRYLVLMKTGGVYADVDVMLDTNLDSFITPSMSFFAPRDIVGEYAGQPFCLWNGLIGAAPGHPFLIRAVERLVNLILDRSDLYDMERDICRRSEKPIELWKVRAEPLLLFSGPCALGVAANEALNRSSLEPFDIGWISMENLGFGGKDDHGDALILVGDKFDMGAFRISDPERNFVVASTDLDGVEKKARIMANPTIVERNLNDTRQKQLPHYSKTAKGVYVWGSARVYKDNEVANEKIKFFPQYHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G303</accession>
    <name>B7G303_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_42126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181703.1">
        <property type="nucleotide sequence ID" value="XM_002181667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G303"/>
    <dbReference type="FunCoup" id="B7G303">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G303"/>
    <dbReference type="PaxDb" id="2850-Phatr42126"/>
    <dbReference type="GeneID" id="7202398"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42126"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_2_1"/>
    <dbReference type="InParanoid" id="B7G303"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC46917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26726" checksum="115A0099D1684BF3" modified="2009-02-10" version="1">MSMNIFRLAGDMCHVFSIIVLLLRLRVAKNAQGISLRTNELFLLVFVTRYLDLFFNFFSIYNSVMKVLYIVSTASIVYTIRFKEPIKSTYEKSQDTFLHWKFAVAPCFAIALITHLIGSKRFDMVELLWTFSIYLESIAILPQLIVLQRYREVENLTGNYIFFMGAYRALYIVNWIYRAHTEKGYKHHWVVYFCGVVQTLLYADFFYYYLKSKSKGGKFTLPTKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3C7</accession>
    <name>B7G3C7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181764.1">
        <property type="nucleotide sequence ID" value="XM_002181728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3C7"/>
    <dbReference type="FunCoup" id="B7G3C7">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3C7"/>
    <dbReference type="PaxDb" id="2850-Phatr47430"/>
    <dbReference type="GeneID" id="7202460"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47430"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_2_1_1"/>
    <dbReference type="InParanoid" id="B7G3C7"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="125" mass="14222" checksum="AE50A0D95EA2FA1D" modified="2009-02-10" version="1">MNAPERASSFLLDEDSGERKIVYTTDTKVTNAGTFRLNKEDHTVLNLLRMQLLRDPGVRFAGYIHPHPLINYMELKVQTNSSHTSPTEVLSNAIEDLGSETDHLLKEVQNAMENWRKENQDVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3K6</accession>
    <name>B7G3K6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_54749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181807.1">
        <property type="nucleotide sequence ID" value="XM_002181771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3K6"/>
    <dbReference type="PaxDb" id="2850-Phatr54749"/>
    <dbReference type="GeneID" id="7202602"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54749"/>
    <dbReference type="eggNOG" id="ENOG502R93N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450172_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3K6"/>
    <dbReference type="OrthoDB" id="44002at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852966" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="80907" checksum="DD7D8BD4164D1B09" modified="2009-02-10" version="1" fragment="single">MTFCRMNARRGHLLFIFRVFVVGVKTSLLRLIDACSVCPDSRNFTLPEKAISIPGLESITTCQQLGSTVSILLSDNDPLCKTVQSLGTFCGCPKAETACEICQSGQRLSRPARELFFLSLEGIMPSCELFEAYLHSLASDDEVCIASIFLLADYCGCTSEADDILSGDDMSSIGGCSLCQNMDDLEMETEVYFPGFPLNTCGQFASTANAVSSPEADTCLYLQASIGTLCGCSVRNPATQPCTLCSDRSAPSRPSQMLPLLSSQFAGLTPTCEILEASLLSVELSSDECKVGHLLGGVCGCAPVEDHCVFCPEGDPIPEYLRERELPQFARFLDGLIATCADIEQAQTQIPTESLICSRGKHRKDLCCGGHFQYLGTSTVRKQAVLAWLPRGVALLSILGSTYVLSNIVRHKERRATIFHRIMIGLTVSDIVSAVAWGFTTLPVPANDDFGAPSKIYGARGNGVTCAIQGFFIQLGFTSIFFNVALTTYYVLVIVYNWRETRLIKLQYWFYTIPVLLGSTLAFAGIPFYTNNIMACYVNAPPLAEKYTVIALLAVVPVCFVVLFCTTAMARVYLHVRHQQKRASNWRMGGSGKCIEQQVLWQSVFYVGAFYISWPIQVVGIFMSEPPFREHTPYAFWLLMVSLAPIQGLLNFFVYIRPRLSKKRDSAGSSPADSGIQGSSWLLSTRFAKVLSIFERQREARDETSLLNEQVSHKRNEANDLDPKDFQEDPLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3V2</accession>
    <name>B7G3V2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181675.1">
        <property type="nucleotide sequence ID" value="XM_002181639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3V2"/>
    <dbReference type="STRING" id="556484.B7G3V2"/>
    <dbReference type="PaxDb" id="2850-Phatr47285"/>
    <dbReference type="GeneID" id="7202322"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47285"/>
    <dbReference type="eggNOG" id="ENOG502S4BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077993_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3V2"/>
    <dbReference type="OMA" id="NYVLCDL"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="30997" checksum="A2783F696A6F668E" modified="2009-02-10" version="1">MSSSSAARTNLTSQSVITHRDQLVGKGSFRLVYAGTYVGGNRNAQEAVCKQFKPHCSHLEDYYYSNDFRIIDKAVDYAEDWNGMCEVGKEILVTRGNVMNAGRAKYMVEPLIRDFTRFTSNNGWIRYDGDAELAMEAYCHYTYHRSGGRLIVCDLQGRYRYNSYRQNKCRFELTDPAICSRDRQYGPTDLGEKGIESFFANHECNRFCNWDGYWQRPRSARAWFKLNQGTSMFGSDSTHLLLTCNTARFNASLQPIYDDNEDSSDDDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3V7</accession>
    <name>B7G3V7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_37460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181677.1">
        <property type="nucleotide sequence ID" value="XM_002181641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3V7"/>
    <dbReference type="STRING" id="556484.B7G3V7"/>
    <dbReference type="PaxDb" id="2850-Phatr37460"/>
    <dbReference type="GeneID" id="7202324"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37460"/>
    <dbReference type="eggNOG" id="ENOG502RYZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1306975_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3V7"/>
    <dbReference type="OMA" id="RFHAMEN"/>
    <dbReference type="OrthoDB" id="61042at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="211" mass="23335" checksum="36FC98C41E2C5DC2" modified="2009-02-10" version="1">MMNSVARNKLRIVAAGRGRSMCLDPIVKAVLDLTDSIEEKEIRLVYLGTATYDKNDAFEAQTHAYSRLSNCKVIKLEVSEAAQKNLSHDEIRDVIDSAHVIMVSGGNTLYAVKRWKQLKIDAMIRNCVIQKNPPPVLCGGSAGAICWFEYGHSDSMDPTTFFSSQSSDDCAALAGSLELKASGISLRYAYHITTLPRAMVSRDHKIQMPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4C0</accession>
    <name>B7G4C0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_3730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181886.1">
        <property type="nucleotide sequence ID" value="XM_002181850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4C0"/>
    <dbReference type="STRING" id="556484.B7G4C0"/>
    <dbReference type="PaxDb" id="2850-Phatr3730"/>
    <dbReference type="GeneID" id="7202829"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3730"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_73_2_1"/>
    <dbReference type="InParanoid" id="B7G4C0"/>
    <dbReference type="OrthoDB" id="35715at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF143">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="300" mass="34250" checksum="56E9790B7B0C909B" modified="2009-02-10" version="1" fragment="single">LSDLDKHRVLGKGAFGEVWLVSDTKKAGKSFALKSISKRTLLESKQEQSVINEKEFLCLLQHPFILNLVASFQDEENVYLLLPLVPGGELFNVLQKQKQKHLGLVNDHAAFYSACTIEAIGHLHQRQIAYRDLKLENILIDTEGYCKIIDLGFAKVVVDKTYTLVGTPEYLAPEIILSKGHDKSVDYWSYGVLVYELLVGHSPFYLKHSSQIDMFKRIVMQKYTIPETVEGHARVLIQDLLIRKPEKRLGNLSKGYFDIKKHAWFEMSKIKFRALLKKTLEAPWKPHLSGATDSSNFDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4F8</accession>
    <name>B7G4F8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181906.1">
        <property type="nucleotide sequence ID" value="XM_002181870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4F8"/>
    <dbReference type="PaxDb" id="2850-Phatr47657"/>
    <dbReference type="GeneID" id="7202862"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47657"/>
    <dbReference type="eggNOG" id="ENOG502SNBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433115_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4F8"/>
    <dbReference type="OrthoDB" id="75502at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909:SF1">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855404" description="PDZ domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="506"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="583" mass="59475" checksum="83C883EEF20454A0" modified="2009-02-10" version="1">MRMPYRITTALAWAWTLASFTHAQMGTTAPVAAPSVLPVVTPTLLPVAAPTKAPAAAVVPTKAPAAAVVPTKAPAATATIAPVAVATTAPVAVATTAPVVVASAAPSAAAVNVTTAPVAVASAAPLAAVASQAPSSAPVMVPSALPTGNTSPAPSVVPTDSPSAMPSGIPTKAPTATSAPTAVATESPTMGPTVAATTGTPLRVAFQGIQLVLPGVITLNQGAQADFATVTDQFYEDFYKLTESSRRQRALQTFQSAGIAGLRSTTTFRTQMVTSDNSGPTNTIEYDQLLEYRVIDSNPLSPPDLIVAPFLLSDINRNYTDRLRESNSAFSTIQDGGLDPPVVPVNGDGGGDDGLSTGIIAGIAIGAAVVAGILGYICYSCMNRESNDEYVPSSSPTPQAFSIANSEEVSTLHDPIRTVGSGGGYGDQSVATVDYDYSKAYGGVGDASVVSSAGGTLGENTRLTKDETTTGTLSRAALGAGYDSEAQYDRDDSVREEIIEVVAPSGKLGVVIDTPDDGAPVVHAVKDSSVIAHQIKVGDKLIAVDDQDVTAMTAIKVSKLISKKSANPTRKLTIIRSSLYDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4X5</accession>
    <name>B7G4X5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182313.1">
        <property type="nucleotide sequence ID" value="XM_002182277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4X5"/>
    <dbReference type="STRING" id="556484.B7G4X5"/>
    <dbReference type="PaxDb" id="2850-Phatr47795"/>
    <dbReference type="GeneID" id="7203038"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47795"/>
    <dbReference type="eggNOG" id="ENOG502S0Y3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_1_0_1"/>
    <dbReference type="InParanoid" id="B7G4X5"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF53">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="1">
        <location>
            <begin position="61"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="523" mass="56943" checksum="8B22E2B4CC50202D" modified="2009-02-10" version="1">MPSHKATSRHAAVWGLTETRFLSKPCWYRLIPSETSLFISLTSCMNFSEACRLAPLESAQLSVGFCAFTIPVEIDQPRSILSNGPSTILSLERGSSSIVLLEDADGDGVADSRRTLATAPDLNHGLALHDGYVYASSDQNVYRWAYTEDFGSVDPSPTLVVNNINADGQGGAPFGHRTRTIIFDGSDRLYISVGSAGNVDDDSFRSRIRRFSDLDPSNFPIDFLQGEVFADGLRNEVGLAFDTHGVLWGVENGADNLERSDLGGDITNDNPAEELNRFREEDVGRHYGYPYCWTEFLLSPGLGQGRGTAWAWPTFLANGAVTDAQCRNNYIGPVVSMQAHSAPLGITFYRWKEPNELPQDCTGGFPRSMDGFAFLAFHGSWNRDIPTGYKVTYVPMDENGEALGEPVDLLAHIAPNASWASGFRPVDVDFDSCGRLIVSSDGSRQDGAYRGSGIVRVEYQTLESSLVPGPSAPPTAINTDTVAPVPAPTITQPPLASPTSAAKNWGYQWSVALFLLMVQDLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G518</accession>
    <name>B7G518_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_51088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182169.1">
        <property type="nucleotide sequence ID" value="XM_002182133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G518"/>
    <dbReference type="STRING" id="556484.B7G518"/>
    <dbReference type="PaxDb" id="2850-Phatr14401"/>
    <dbReference type="GeneID" id="7202968"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51088"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="B7G518"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="477"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="593" mass="64547" checksum="8461075B3EF0A9CE" modified="2009-02-10" version="1">MKFTVASISGSSSASPTSNGATKEDVAKPKIPRGLRALPAAAASSRVSPGSELGMLRSEASSIDQWWKDPRWKNTTRVYSSTDVACLRPSAQARNNLRQAPGVSFSSQQSDKLWSLLVQLQARKGYSHTFGALDPVQVTQMAPHLSSIYVSGWQCSSTASSTNEPGPDFADYPMNTVPNKVDQLVRAQLHHDRRQQQERSEALLAGKDPGQPVDYLRPIVADADTGHGGLSAVMKLTKLMVEAGAAGMHLEDQKPGTKKCGHMGGKVLVSTQEHIDRLVASRLASDILGVNLILVARTDAEAATLLDSNIDGRDHPFILGVTTPGMPTLQDAVAKAPAGQANQVTTEWTKQANLMTFGEAVLATIQRSSKPAYQKRQMEQRWMASNPNTLSNAQARRMADEILGQANAVNFDWESCRVREGYYQLRPGIEYCIQRAIAYAPYADLIWMETKIPAIDDAAQFSRGVHAVHPHQMLAYNLSPSFNWDASGMTDSQIASFNDDLGRLGYVWQFITLAGFHGNGLVMTKLARAYGDRGMIAYVEQIQRQERIHKVELLTHQKWSGAELVDQMVNVASGGVSSTAAMGAGVTEAQFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5E4</accession>
    <name>B7G5E4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_47933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182232.1">
        <property type="nucleotide sequence ID" value="XM_002182196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5E4"/>
    <dbReference type="STRING" id="556484.B7G5E4"/>
    <dbReference type="PaxDb" id="2850-Phatr47933"/>
    <dbReference type="GeneID" id="7203125"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47933"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336331_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5E4"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="623"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC46133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="848" mass="91759" checksum="0BF2FC5770C2C4D6" modified="2009-02-10" version="1">MLEGNDNIGSNPAGAATGLRRRRGVVDMAPDLNNENDATAAHEILEAVHPPQRPLNNPLPRQHSASRVASTASSFTARRMSSWYGWLSAVAACLAIVTTNQPEPFWQLVRECVPAGIVEPATSIILSGAKSTPSTLTWNTEAWGGFFSFLTPPSSTSTTEFWSNGMEQRQEISSPIVEENNRKVPKYLETKGGGIPVWLRWIPGIYSPAPSPSLSEGTAFTKNRKDSSSMAAAIRGKLDSFETTILQAAFTVAATVEVIVWTTLSLISKWPAVLKSLVDPAILHPSASTTATDLIDKILTSTPRLLCIANIFLAVTYIFHQAVAEWFLGSNGSSRRDMASREQRLGGFLVFKLLLISAVVGPDTLDLLILLSWYTCLSLLRSLGVLCANVTTHTSQSGQPPRPGVWHLLTGVLVADFLAAAVCVGLFHGAGWGMVALLTCDCALLAMDIICHLLSHLSQVLEQQHGRVVQRWQEQRGLGEEPVSTGRVWRFPESAEGINEHDSVDADTAPDQGPSAGMEHRLEQYEKQHSRRVAILDSTIFALQLGGHVLTVAHFLHIWKVHGFQFTLIDGVLALHLNSAITSLSKKIASRRNLHRIARDLNTTFVDASEWDLRKAAASGDVCCICLGVLTSDVKKISCGHLYHTQCLREVVARARSMQTARCPLCRASVVDGRYANDTSTAIPRNERGAEVNEATLDQASGRPPDTVGVAPTAGPNAIGTLPNGGNALFRFSTEGIFPAWLPLPGFSFEVVRRTAATSNANTTVDLVPSQIPEPSFIRRFLILAGAIPLSPEEEAVAMEQLVDMFPQYDRADLLRELRARGSSEGVAEIILLGAFTGIPRGGGGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5U0</accession>
    <name>B7G5U0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_14760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182602.1">
        <property type="nucleotide sequence ID" value="XM_002182566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5U0"/>
    <dbReference type="PaxDb" id="2850-Phatr14760"/>
    <dbReference type="GeneID" id="7203411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14760"/>
    <dbReference type="eggNOG" id="ENOG502SCY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5U0"/>
    <dbReference type="OrthoDB" id="46933at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="415" mass="42511" checksum="187B043A494D8727" modified="2009-02-10" version="1" fragment="single">AFPLGLCEGDCDRDSDCQGNLRCFQRGASRESVPGCTGADADATRFDYCYDPLTPTPASAPPSVCEGDCDQDSDCAGDLRCFQRSNGHLVVPGCAGGAADVSHFDYCYDPTYGPTLVSVQLALSTVSSARADPSLSSLGSEVSSGLPDENRSDRRLQSVAVVGDNGSPSSRFPLGLCQGDCDRDSDCAGTLRCFQRNGGQDVPGCAGGAKDRSKSDYCYNPNASVRPPPAPVATRPIPAPVPSPASVAVVGNNGSPSSRFPLGLCQGDCDRDSDCAGTLRCFQRNGGQDVPGCSGGSNEGSRSDFCYDPAPEASKPVPVPTRPNPAPVPPPPAGPVVSPVPAPVAAPSPSGPRPVVTVVGDNGSPSSRFPLGLCQGDCDRDSDCAGTLRCFQRNGGQDVPGCSGGSNEGSRSDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Y7</accession>
    <name>B7G5Y7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182630.1">
        <property type="nucleotide sequence ID" value="XM_002182594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Y7"/>
    <dbReference type="PaxDb" id="2850-Phatr38465"/>
    <dbReference type="GeneID" id="7203261"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38465"/>
    <dbReference type="HOGENOM" id="CLU_1126366_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5Y7"/>
    <dbReference type="OrthoDB" id="10547775at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="28405" checksum="F7A75EB315001020" modified="2009-02-10" version="1">MNAVAVIGGASIQKLRFSDVNEIREFTQEHQIVSDEIWFASEEYAEIKARSRLEVKEWRRQGFGVLLKESFELPRKDTQSYIIAFCQLEGSLSRRGLERQLSRQHGEERSDLKDRSRRAVITHQMRLLRQGLPLDEIAEQLGLLYREITRPAKIFARRMAKGDEIVAKEGESNEPAEKILEERERRNRHQMMERRLSNFSSMSGMSGTSLDSIASRRRWNSVPGKARKPPCPGSPASPVEEYYAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6N6</accession>
    <name>B7G6N6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_48300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182889.1">
        <property type="nucleotide sequence ID" value="XM_002182853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6N6"/>
    <dbReference type="STRING" id="556484.B7G6N6"/>
    <dbReference type="PaxDb" id="2850-Phatr48300"/>
    <dbReference type="GeneID" id="7203729"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48300"/>
    <dbReference type="eggNOG" id="ENOG502QVQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024605_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6N6"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="70"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC45625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="746" mass="83448" checksum="716AECEEEE606752" modified="2009-02-10" version="1">MKKAAVLFIITLCIKGSTISVSIIFWPQISSYGSHFIDSLSNSSVMDAKRRLSFFMGIGMVFFPGANGNNSWIDIETPLKKRTTKSLVDGSTYHLVMSDEFNVENRTFKDGHDPMWTALDRSDDDASSAGGGSLQFYNSSAVSTENGFLKIATYLETTSWTRYDHVNKHWKTERTNFTSGMVQSWNKFCFTGGIVEVDVVFPGEPFIGGLWPAVWMLGNLGRATYEASTNNIWPWSFDTCDREMQDAQAISACNRENHYGMHPFQGRGATEIDIIEVMTGDSNGPLPSTEPPITLPYGDMTLQVAPGVPKNRPQSGSLPLRKNTFSDNGHTEFLANVWYKDLEMHGNTSINPFFYGTYLGETKPGEPVTRGKHEAFQADAVGAAHQLTPAHFKRPHTFRIEWQPGKGGRLDWYTKGYRMNETTYMEGDGEGQEWTHVFSLKDKSLSDLMGSQIPNEPTYLIFNTAISSTWGFPYDPPDWCPKCFDCNDPTCSCNFYPGFCQMLDSRTVAMLIDSVRVYQSFNTSAHVGGKHTLGCDPPDYPTREWITGHEYRYMRNEPFSYKDKAHSLQPLQRGGGVCRDDSDCGGNVSLTNLTAVYDMLGTDSERKLFSTESRETVDLVISQGQCASQTNTFFSSKSWTGKVCRCRVGFTGPMCLSLDRIDTFPSAHKIRTDVSPFNRIANFEAPTFMLTAIASMIVMLLSILVSKVVDEKKARKRKSVSRQFKRPTFVTTSNDSNVTIITGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Q1</accession>
    <name>B7G6Q1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182770.1">
        <property type="nucleotide sequence ID" value="XM_002182734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Q1"/>
    <dbReference type="PaxDb" id="2850-Phatr48314"/>
    <dbReference type="GeneID" id="7203787"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48314"/>
    <dbReference type="HOGENOM" id="CLU_1470944_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6Q1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="184" mass="20294" checksum="78A5588735F534DC" modified="2009-02-10" version="1">MCNAKSAMNNILHGPASEALERTTKRRRIGSQNQSMPPAADPFSSEDLFQSVTSASDEGFPSIGWNFDDDETDLEPFMATTGDNFRHRIKGTKRERGGLLRCKSFRQGLSGIALEEHFCSTSKSLETCDTLQVCNERESSLCVTKNLPHVPFGSALHGHRFRDLSATSLIRKEGPKPHALCPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6T6</accession>
    <name>B7G6T6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182787.1">
        <property type="nucleotide sequence ID" value="XM_002182751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6T6"/>
    <dbReference type="PaxDb" id="2850-Phatr38777"/>
    <dbReference type="GeneID" id="7203805"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38777"/>
    <dbReference type="HOGENOM" id="CLU_954616_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6T6"/>
    <dbReference type="OrthoDB" id="46637at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="292" mass="32268" checksum="89286C5347AFBED8" modified="2009-02-10" version="1">MTTMTSTMPSTRNALRVDTRGPTSRKPLPKVQPTAPIRNSSGGRKSIDRTSQHANKVTSQTQMSSSAQTKQEEMDSTLAQLKATLSRFTRSNNRKLVLQTLHNYRYLKCIPLESLPVAPSSQAAWQELETQVCARPLILNQLQLAPTNELTTTLYSLCEKLCTDLPITAASVCSSIIVKINQDSAATDVYFQLNAILGSQELILQQPPSLAHTNNTKVTGNAPKQTPTQLDLYKADGVLHGRLTHRLAVGVFRKSDLSNSKPWFWLTATVMERFNVSTGTSCRQVFVHVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6T8</accession>
    <name>B7G6T8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182915.1">
        <property type="nucleotide sequence ID" value="XM_002182879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6T8"/>
    <dbReference type="PaxDb" id="2850-Phatr48346"/>
    <dbReference type="GeneID" id="7203806"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48346"/>
    <dbReference type="InParanoid" id="B7G6T8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012891">
        <property type="entry name" value="GCK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07802">
        <property type="entry name" value="GCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="270" mass="29869" checksum="ECA7EBCDE5383D03" modified="2009-02-10" version="1">MIRHAVDGSVLRKRPITSFGAALLGGAWTSRNRIVIACDRHPPQRWLLPTRSCATTVAPEDFTLDDSCPLCRQFRQGPCAAPFNSWYACTERANAASQDHVAVCSESFAAFHACVASNETFYDRATGPDQFHSSGPDESAATATDVYTSSCEAWQELIDNDLADVKRLDFPSHLRPVWRTSADSRLSAEFVVRDLVLVYVEALESDNSRIMGARLIAAGAKADMTVIRDRKETDLVSFAIPSASNRWLRISAVYEDSDDVVVYEMTLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7B2</accession>
    <name>B7G7B2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182999.1">
        <property type="nucleotide sequence ID" value="XM_002182963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7B2"/>
    <dbReference type="STRING" id="556484.B7G7B2"/>
    <dbReference type="PaxDb" id="2850-Phatr48486"/>
    <dbReference type="GeneID" id="7203768"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48486"/>
    <dbReference type="eggNOG" id="ENOG502RRCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516292_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7B2"/>
    <dbReference type="OMA" id="YLDEDIM"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="528" mass="58293" checksum="4C067BD4EA104DB0" modified="2009-02-10" version="1">MTEVRAESLGGSGLFATQDYQIGDQILQENTPLIHLAPTTKELESAIVGALVEQTIETNPAGTTDDDKRSLWRAIQVPASIKEAHYGKFKGMVQAALCFAASEVSVDSKQRFLKLYCPPLTTTEKSPSANSEAEADIIEVSKQALQYVKENIRIDSNLAQNGAMDDGTLQKVMLLWSGNSFEGGRVYDSISRINHSCDPNAVVQLGLGTEQDRQSIVACAPIANGDEITISYLGLLLYADRPTRQASLLGTKHFTCACDRCKTSLPDNASAIPCPICHPRRTGQRQLDEDVQYDDEQSVHYAMIRQTPDHNAAQKRMECEHCHAKIFPSDSNHAVLWKIATAVTDKTVTFLRDHAAMEKNKLNDDGDDEEAEQVREELLEQQLQICSSVLGAQHWTTNILLLLLLDQKLQALHGGLLSDNQGEADLGSIAEAMDMLERLFRYVNRLGLRLHRGHLLADVTMGAARALVSLGDTGSQKYAAEWMAKVDDYVQSFEPEDVQKVAHALKAAWTRADLNPSPRKRAKGDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7M5</accession>
    <name>B7G7M5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cytochrome-b5 reductase</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_29658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183168.1">
        <property type="nucleotide sequence ID" value="XM_002183132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7M5"/>
    <dbReference type="STRING" id="556484.B7G7M5"/>
    <dbReference type="PaxDb" id="2850-Phatr29658"/>
    <dbReference type="GeneID" id="7194785"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29658"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="InParanoid" id="B7G7M5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="259" mass="28135" checksum="543E7C4AE1FA3E97" modified="2009-02-10" version="1" fragment="single">MSSKSNVGSALTGPPVCSLVPPGVCQFGPEFTAASLLGRIKVSPTSSLLRFGLPDANQPLNLSTCACILAKITVDGEDFTRPYTPISTNADIGRFDLLIKNYGEDTKMSRYMCEVLQPGEAVHFKHIDPNVKLQAPFPFDHILMLVGGTGLTPMVQALHAILGSINPTIDSKKPKVTMLYGSKSSDDILGKDLLDQWAKDYPEQFKLITVLSDEPEDSDWKGERGYITKDLVADNFPSPDADNLQVFVCGPPPMYNALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Z0</accession>
    <name>B7G7Z0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183101.1">
        <property type="nucleotide sequence ID" value="XM_002183065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Z0"/>
    <dbReference type="PaxDb" id="2850-Phatr48642"/>
    <dbReference type="GeneID" id="7194840"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48642"/>
    <dbReference type="HOGENOM" id="CLU_331681_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7Z0"/>
    <dbReference type="OrthoDB" id="48469at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="94624" checksum="F9AE03ADB78BD925" modified="2009-02-10" version="1" fragment="single">MVGLRFKRSVGPAADVKELQFVIALHQTCAPDTRENAAVGSVDIARLLASRHGLHITSTQAEDLVRSLGGGDTIGKAPEKKKTPSAIRFGLFSKKQALSTTQADGEVPALSASRLGALLHHSSTHSSMENNNNSRLLESASLGLRQNGGLETNSSLLSEAKEELADPSQYTEEIDELDDRDETEEEAVVVEDTFTNDMFSEQYLDMVQLLSTLLIPTFARAVREYKVGVDILPPIPEPKTNSWFSPFSRLVWQLRTMLLHREQTVLDSLRASSDGSLLQQILQIMVTKTGESEPTVDEDFVRRLLVRYGESERAENIKLVQQMVEMASSPSGLFDEEALANAVASDLTQWDVPSEGRLSSMFYDIFYESNPHDVKNLEADDLMSGADEEAAEKKEPTKCAHACCKCFSCVFGRCRASPLFKAELFNIDMVVDCHSSAGSFAVSRLVQVETLTVRLFSLIVSSGVYGTAILAQPDIKNNCNLEEFWCKIFQTVFSWVVVMVVLSASGVLVLMPLSSGNNPYRRNPRRQLYAVGAAVVYAVVPFVLMNVFVEETKNDEERAIDSDEFRVLREFTMILGLILAGLFLIQMFLSSLRLRRGFSTRRAGVFDHITSTSNTRGEARLKHAATRKTRKIMENAISVHRIDTEAALRGTRQQLHRHQAAVDTSTMRNFIVHGEQYELAGGTMWTWLRILDGSLFDTEGIWLNTRLIVLQMAQVIVAAVFSFLLFLGVGLLAESAGNARDDLKPGFPSWVSDIVPTPLMVRVSLYPATIAAIVVMVLLISLYIPSAVSTILKYRSQFLPSLGSPYFVKYRAAVDYTYVNTANAIYGMIGAASLYWLMVGWLIFLCVWPFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G842</accession>
    <name>B7G842_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183272.1">
        <property type="nucleotide sequence ID" value="XM_002183236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G842"/>
    <dbReference type="PaxDb" id="2850-Phatr48711"/>
    <dbReference type="GeneID" id="7194988"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48711"/>
    <dbReference type="HOGENOM" id="CLU_701077_0_0_1"/>
    <dbReference type="InParanoid" id="B7G842"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="387" mass="42725" checksum="F4EFAC0C9EA3A2EB" modified="2009-02-10" version="1">MIFSLLSGADTSIFLGSIVFLLVFVIGAENGVSSAIFALHTLIFVPSLISLIWRWRTCRYDVLFGDWAEDVGSRSTKQPLNPSSLSLENQQVLLNRVETALSTSPMTNVLVMAPSIALFYILLVRLFVGQDIFAGDPSQLDYGWKFGIVNGEDNIAFVPEFNSYGHWIQGVLSAAFAFPSLNATVCQFLMCRAFRKASFYGPTSSGLFRTVHFASWVLTIYPAYNLVKRFYRYSEAFAGSSFGNNGLEWAYGFMNGIAVGQMVTSIHRHTLFVWIRTDGQTFEALSRERDSWVVRGGGCTAFSGGFCVCLGILEAMLGLLLVFSVLSAAALFGLTWHGCLGGGNDCLNYEADVDTRTLLFGFCIIPTVIICYAALQECWRLKNGQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8D4</accession>
    <name>B7G8D4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183449.1">
        <property type="nucleotide sequence ID" value="XM_002183413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8D4"/>
    <dbReference type="PaxDb" id="2850-Phatr48788"/>
    <dbReference type="GeneID" id="7195057"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48788"/>
    <dbReference type="eggNOG" id="ENOG502SAS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658011_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8D4"/>
    <dbReference type="OrthoDB" id="2099474at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="424" mass="47439" checksum="B00CB422B60F5E3B" modified="2009-02-10" version="1">MTFTCRMDPKSVRRYVPEQVSLSDDAPGWLGDDTHCVKGPICWKCKGQKLLRSHEICTVCQGQGRVSPKRADVEGARLDGKITRGRKSSTSWEPIGPTPYALTAELQNEWTQMIRTVSRVKIDVSIDMTEQAEAGENLPLWIPKPGEELCNLVGSWRILQRVGSHRWTTDDLCTAYYALQTAIDSGLNRKQEALRYLDLGTGNGSVLQMTYWALCTNSIQISEAVGVEARSEAVALGRRSLSFNIDSRTQNVRIHHGDFRSVELGQLPFDLITGTPPYFRVDFEIASHENSEEVSAIINQGGMPTSKQSAPARCEFRGGIEAYCEAASKFLTPTKGRFVVCENWLNDKRVAEGAKAASLSIIKRLDVIGRTGKDTLFSVYVMAKEDRLVTNSIEIERLEVRGYDGDWTSTYKRRILNSMNIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G985</accession>
    <name>B7G985_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hCDK4</name>
        <name evidence="10" type="ORF">PHATRDRAFT_49025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183728.1">
        <property type="nucleotide sequence ID" value="XM_002183692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G985"/>
    <dbReference type="STRING" id="556484.B7G985"/>
    <dbReference type="PaxDb" id="2850-Phatr49025"/>
    <dbReference type="GeneID" id="7195407"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49025"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="B7G985"/>
    <dbReference type="OMA" id="YQFPQIP"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="388" mass="43217" checksum="AA4CB9F5A2E0E77F" modified="2009-02-10" version="1">MDRYTVGEKIGEGSFGQVYFAVKHSTNEKRAIKRLKGAFAWEKVVPMRELQSLMQLTHHANIVQLHEVHLVRGVVHFVFEYVPNGSLHDLMMLRAKAEQGPLEEIDVRAIVQQVLQGLEHLHRHGLMHRDIKPENLLLAGTVVKVADFSMARGVENMSPLTSYVSTRWYRAPEVLLASPDYDQAVDIFATGCILAELLSLEPLFPGRSEIDQLQLIFALMGQPTSRTWKEGFRLLQRLGVIVDGASTAKASISPRQGLVQHLPSVSAAAVDFTFAVITLNPRDRLTASEALRHPFLKPLLRQPILVNTTTSTPARSKASSGPTAVTITPFQRPSMTDVDTPERLTHTALPVGSAKRRKPTDASEMYISSAFEVQWRKSTHTIARLPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G992</accession>
    <name>B7G992_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183731.1">
        <property type="nucleotide sequence ID" value="XM_002183695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G992"/>
    <dbReference type="PaxDb" id="2850-Phatr39652"/>
    <dbReference type="GeneID" id="7195411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39652"/>
    <dbReference type="HOGENOM" id="CLU_944809_0_0_1"/>
    <dbReference type="InParanoid" id="B7G992"/>
    <dbReference type="OrthoDB" id="55675at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="24035" checksum="090B13DD443B6C7D" modified="2009-02-10" version="1">MSCHFPPEATLQEAILILWCQTKELCRSIWHRILHIAIRPLQQRKQLRIRTSTLGSLPELEEVAKPISESLSSSAQPQFNNDIFDSVGEEKKEYASLESLDAIVSEIASSQSSREPLGAAKDGNGLPHHPIDWSNQELEPAFLNDSDYPPGWMVYHSLLGVVAKNEAEEYERRLSKNPTPEVQEEGANELSHGASPAFLKVEGDCEDYTPRISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9K7</accession>
    <name>B7G9K7_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183653.1">
        <property type="nucleotide sequence ID" value="XM_002183617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9K7"/>
    <dbReference type="PaxDb" id="2850-Phatr49128"/>
    <dbReference type="GeneID" id="7195343"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49128"/>
    <dbReference type="eggNOG" id="ENOG502SA42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548013_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9K7"/>
    <dbReference type="OrthoDB" id="205763at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="498" mass="56296" checksum="BABC5ADC021C3B56" modified="2009-02-10" version="1">MPKATETKGNLGRRRSRVAQSSISSNRNRTNNGVRVWFLMAIVLLVATLYVTDTIAFAPPLPLQQNQRQEQHPLQLSLYSKNDPTHGPYEPSSCYHSRRRTRQASSTFTKSFTSTCGNSLGSALQASCLVPPPPPSHLQFLEQGSVWEDAPSVQASQHHRSTRKYRRRTVHGSTWKHGSPSLQDPAIVTLVKKAPHDSITAPTNSNNAWEDLVQTVLPSSSSSSSRTESTVTSIDSDPAYQRRKADWASKYASVEALRATFGVNRNGFWGDLDADRTRRLYKTLLPKALLELHAMGVQAQDLAPLAYRARVAAKLYARERSYVTLRIGSHMLDGIRTWQRYGQFDVTGMSYTQVWEKYAKAILEDADEDNESHAALREEDVTAQICLKILESSCRSNTMIDRLCLASGSHNSHHEDHDTTCLVPPHHCDDLNILTQDLERDVWSILDEAQTRAHDPRPHSPTEHPPSYNVQRWRTLRTLARVKRRLERLQHHPHPDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9U7</accession>
    <name>B7G9U7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183953.1">
        <property type="nucleotide sequence ID" value="XM_002183917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9U7"/>
    <dbReference type="PaxDb" id="2850-Phatr39869"/>
    <dbReference type="GeneID" id="7195683"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39869"/>
    <dbReference type="eggNOG" id="ENOG502SX3I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1457180_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9U7"/>
    <dbReference type="OMA" id="IGWNENI"/>
    <dbReference type="OrthoDB" id="66462at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="21066" checksum="6169D7D6FF33B987" modified="2009-02-10" version="1">MFLAALDKFANTPWLMVAAVLVHILCTQYMSSLTQQLGKDNPPPDIRFGYTSESLNAWYDAIGEDGCKIYQQHVFVDLFPYMQSYTLVGGALLLQQLRIIGWNENIALIFPMVMLMDMIETCIPAYGCSIYPEKRLRPAYVQASASANQLKWTNFGIGMSILSILFVYNSFFPPKHDEAKAEEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9X7</accession>
    <name>B7G9X7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_15730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183967.1">
        <property type="nucleotide sequence ID" value="XM_002183931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9X7"/>
    <dbReference type="STRING" id="556484.B7G9X7"/>
    <dbReference type="PaxDb" id="2850-Phatr15730"/>
    <dbReference type="GeneID" id="7195699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15730"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="B7G9X7"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="442" mass="48389" checksum="A9DB899A80C10069" modified="2009-02-10" version="1" fragment="single">DPNRVKITTMPVSGRAAEDIVQELQHFAEKEDKMWQLGKVSGTVYSNSDEHTSLMNRVYAAYSWSNPLHPGIWPKLNQCEGEVIAMTADMLHAPPIGSMTSGGTESIILAIRAHWNVYGKRRGIRHPELVCGTTAHAAVYKACDMFGIRVVSIDCNHRHDSFQLNPDRVSKGITSNTIMIYASAPSYPQGVVDPIEALSKIALRYKVGLHVDACLGGFVLPFVDDAPVFDFRNPGVTSMSADTHKYGYASKGTSIVLYRDNTLRHGQYFSYSWWTGGLYSTPTIAGSRPGALSACAWAALVSLGKDGYRERSHLIVNAARAIADGIQLVRGVKLLTPKPFMVVSFTSNEMDIYRIQDYMTKAGWNLNALQSPASVHICVTLNVVPKVDSFLRDLKMSINQVRNEGKGGRKKGTAGVYGTVGSLPAGPVDYSLRAFTDLTLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAG2</accession>
    <name>B7GAG2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.18</ecNumber>
            <ecNumber evidence="5">3.1.3.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_1048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="5"/>
    <dbReference type="EC" id="3.1.3.41" evidence="5"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184067.1">
        <property type="nucleotide sequence ID" value="XM_002184031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAG2"/>
    <dbReference type="FunCoup" id="B7GAG2">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAG2"/>
    <dbReference type="GeneID" id="7195783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1048"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="InParanoid" id="B7GAG2"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="64"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="354"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="623" mass="69809" checksum="C9BB2FE1A2021401" modified="2009-02-10" version="1" fragment="single">RIAIISSERCRPKKCRQECKKSCPVVKLGKLCIEVTPKSKLAFISEPLCIGCGICVKKCPFEAIAIINLPKDLSKNTTHRYGPNSFKLHRLPMPRPGQVLGLVGTNGIGKSTALKILAGKMKPNLGRFDNPPDWEEILVHFRGSELQNYFTKILEDTMKATIKPQYVDHIPRAIKGKVGDILKQKDERSEAEEWDVLNWATTQAELNHLLDRDVRILSGGELQRFAIAAVAVQISDVYMFDEPSSYLDVKQRLTAATMIREILQAPGGDRRYVLVVEHDLAVLDYLSDFVCVLYGAPGGYGVVTMPHSVRTGINAFLAGYIPSENLRFRENALSFKVSERAEADLTKNDVMKAYSYPDMTKTQERGESKFVLHVDKGEFTDSEIIVLLGENGTGKTTFVRMLAGLLKSDEQVKLEEEGMDYEASLAGVPDLNVSYKPQKISPKFEGTVRQLLHKRIRDAYVHPQFVSDVMKPLVIENIIDNGVQTLSGGELQRLAIALALGAPADVYLIDEPSAYLDSEQRINCAKVIKRFIMHSKKTAFVVEHDFIMGTYLADRVVVYHGQPGIEATASSPQSLLTGMNQFLKSLEVTFRRDPVNFRPRINKRGSQKDAEQKKNGNYFFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAT8</accession>
    <name>B7GAT8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184251.1">
        <property type="nucleotide sequence ID" value="XM_002184215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAT8"/>
    <dbReference type="STRING" id="556484.B7GAT8"/>
    <dbReference type="PaxDb" id="2850-Phatr40219"/>
    <dbReference type="GeneID" id="7195841"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40219"/>
    <dbReference type="eggNOG" id="ENOG502QZCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244830_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAT8"/>
    <dbReference type="OrthoDB" id="39806at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="942" mass="106903" checksum="CC88F66670C08FEC" modified="2009-02-10" version="1">MNCQKLKGVTELRKGCSSESSLKAASRHFDLFLEEVILSGTIGGKEKQQLFPIRSVNNSTDSNNIDNSKRLDGDAQTQYSFKTIAVEKINDKLLNLFAGYLTRAEKLRGNKNETQDNFSDGNGISYNTAERYLSSIKNEILRRCLDLGLKRSFDDAQQTRIRQSMTRRFVERAVRNKTPLARSHVTAARNDFLVIALLCIWDGSFPMADMLFYLLTLRYLAGRGQEVAMISRSRVSLGEPSEWADSGDKTFVVRLWRSKVSHEQDLSIVPHQSEMLLDWVFAFAYSAVMNTNPNDSLFPTFAEKVELRNLSAGNINDEEIGNETTQDSTLKAKVDSSKKVTKYFQALLERLIKTSEELVGPNEMARAAGLYQDDEDFSEEFDGSSCVGTTSVNNEPGIFNLTGEEETVGLDPPANAAYYYSGLLHKHGISAGLSTHSAKRSAVEMANESALLLTTWVCFRAGWLMKAVHTIFDYLSFNPKNDRQVSRVFSEWNTPSFRGEILGGRPPRLHPIRLQGFKEAEKVRCFVAALFVNYEDKGIDSNIFCTIDDRKNRLRELRNLYDLLTATILRYLPKFVKVLQEHPNPSHPFRQGQRTCIEKHPFLLRILKASQTAGILWDELKAWSTLVQKDFLERNFESASWSEMLEVVGEEQFSADPRTLGGYMETTNRTMNTIQLGQSRMLETTSIHDARLKELTTTVSIQGQAIEECRQALAEIKTLLKEALGKPDILIPAINQGQEQLPINPSAAERMLEIDQQVLPVYSLPEKLKDMDLTDLFQQWHFQQWHLQMYSGGTKQRGISSQIRFGMEYFSLFLPAQVPPLPTGTVNPMELLAEPWRRQIRFLANKAFEAMADFFETKGLKVPKSLTPFKKAMFLIDASEWPKGPQDPSPFPILSKKGKKEELRNYDCLQKSQEKEKLKVQNRLQKRGSATKQTLPVVVDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAZ1</accession>
    <name>B7GAZ1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KRP2</name>
        <name evidence="10" type="ORF">PHATRDRAFT_23314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184278.1">
        <property type="nucleotide sequence ID" value="XM_002184242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAZ1"/>
    <dbReference type="STRING" id="556484.B7GAZ1"/>
    <dbReference type="PaxDb" id="2850-Phatr23314"/>
    <dbReference type="GeneID" id="7195867"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23314"/>
    <dbReference type="eggNOG" id="KOG0246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_19_2_1"/>
    <dbReference type="InParanoid" id="B7GAZ1"/>
    <dbReference type="OMA" id="IYATQLE"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="85"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="602" mass="67074" checksum="CC48396BFD792BAA" modified="2009-02-10" version="1">MSNRRRSSVVPPKDQTRLKIERMEAEREERRRAMVERKKERAQEEQRNIAAGNPGDVDFIGMVRRWRQQHAQEIEPHDSCDAHPRICICVRKRPISEKERARNDHDSVTCLNPAVWIHSSKVRVDGITKYLDQTSFTFDHAFSEEASTEDVYKHTTMPLLDFVCSGKGGRATVFAYGQTGSGKTHTMNGIQAILCEDLYLQLSDHANAGGCSLKSTKIVLSFFEMYGGFVQDLLNDRNRLKVLEDGQGEIVVTGLQEVEADTVAVFHEIVNTGNSFRTTHTTEANDTSSRSHAICQILLRDKRTNKLQGKLSLVDLAGSERGTDTKSHNSQRRAESSDINTSLLALKECIRALDNKNKSGAKHVPYRSSKLTLILKDCFTSPAAMTTMIATVSPGASATDHSLNTLRYAGRIKEQRAGTKAGDIAKSPMRRKVSPRSADTSSTASDQLPNSLGIDEKTAVVEGSATRFTPRSGTNTMLRKEVLVRRSPSDDLDAVSGATQEETELRRTVQGLFEQEEAILSMHMRNIQENAELLTEEGKLLQEVQRDGVDNEAIEEYICALESVVERKETMILSLQEKLLVFSDALEKEQALSKKVGSLAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB90</accession>
    <name>B7GB90_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184326.1">
        <property type="nucleotide sequence ID" value="XM_002184290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB90"/>
    <dbReference type="STRING" id="556484.B7GB90"/>
    <dbReference type="PaxDb" id="2850-Phatr49621"/>
    <dbReference type="GeneID" id="7198262"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49621"/>
    <dbReference type="HOGENOM" id="CLU_553761_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB90"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="148"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="311" mass="34765" checksum="2EB3A09A6EBB1965" modified="2009-02-10" version="1">MKSKVRRVDVTLDYIDEIEREMDVDENDDNKSTTASGLDLESNPLSEHEIKKSPPTQKERNLPFFNSKRKVIVARSPNDIAPLCMKLTKSIKQSGPNSFPLVLGMDVEYATLELDIRGDLPAMLQLASPDPTGPVGLFWLDKLPNHGKSILHDGEAYKPLLSILASSDIEKVGVGLTSDVRHLLDWWGVSGAATYSPYFIANTVDISEVYSSDTRVADRSLQEMCESVLQLRLRKRKSISRNKKRSHWRAEVLTKQMKEYAANDAACAVEVYLSLCAEESDDSDDSGDDDENDHSSIDHSDADERDPSSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBD5</accession>
    <name>B7GBD5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Little elongation complex subunit 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184349.1">
        <property type="nucleotide sequence ID" value="XM_002184313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBD5"/>
    <dbReference type="PaxDb" id="2850-Phatr49664"/>
    <dbReference type="GeneID" id="7198305"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49664"/>
    <dbReference type="HOGENOM" id="CLU_427307_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBD5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65048" checksum="062BA5BE8F0CA505" modified="2009-02-10" version="1">MDSSVSSQRKRQRAHRNDNAVDWESLQASAGKESLSVLNEVPHVTDRPPTDSATFWNSFAAESRKRRHRPLPSSQALIATIDARGLSRSPCPLIRDFLASLGRVPSTPTSTSADTQGSVGDKPEDETANQPLLHAIDDATKSTMTPGQHQRLRQLQAKGTSLSRQQLGELQKLRKLLIGEQRVYEKAVLEFWKSAADRVFLGLTDDRSKAHAFVQRFWSGGLLASTVVAGKCRQIISVQPEHSFSPERCEHELVGGPASQGAVCKLPDDGQEIALPSRPPRSHLPLHSDKQALQLAKTHNATLITSIETLEVLLQEPANSDWTLPYFCDGETYEIPILDAPLVHSVKTPRLCLEKAFRLGMTEWLESTSIQQAQQPTSGCPQSFIYILLVVPVLKQRSQRILVRRPRGLTDHSGQSLLLHSRIEYFPERGREQPSPSEKALWILDHVLQPTSHVVVGSIDPLRCTILRWDHVSLAHGLVHIPGPFGRSETSALKHWSRLMHILLAMQTIGRGQYVLSYPGQGISVPESGISVHLATPSIESMHREGQPSISPLAMNEKAVERAIRPWEWKADRMEYSFPIDNGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBE7</accession>
    <name>B7GBE7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_40430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184355.1">
        <property type="nucleotide sequence ID" value="XM_002184319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBE7"/>
    <dbReference type="FunCoup" id="B7GBE7">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBE7"/>
    <dbReference type="PaxDb" id="2850-Phatr40430"/>
    <dbReference type="GeneID" id="7198156"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40430"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBE7"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="40053" checksum="F9311898F6380374" modified="2009-02-10" version="1">MGDSISEGTIVDLPVAPGDFVNVDDVVVVLETDKVSVDVRAPEAGALVEILGEIDDVVEVGTNLFRIDTDADAPEAPVAPESTPEEVATHIAEPAPSQTPTSAPVAAASAATKAPPPPPAAKSAPPSAPSGAPASQPVFLGTRNERRTKMSRMRQRVAARLKDAQNTAAMLTTFQEVDMGNLMELRKRYKDVFQEKHGVKLGFMSAFVKATTAALQEIPAVNGYIDNDTQEIVYREFVDISVAVASPNGLVVPVLRNTETMSFADVERNIAAYGQKAKEGSLSLDDMAGGTFTISNGGVFGSLMGTPIINPPQSAILGMHATKMRAVVNEQGEVVARPMMYLALTYDHRLIDGREGVTFLKSIAEKIADPSKLLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBW4</accession>
    <name>B7GBW4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_30609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184519.1">
        <property type="nucleotide sequence ID" value="XM_002184483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBW4"/>
    <dbReference type="PaxDb" id="2850-Phatr30609"/>
    <dbReference type="GeneID" id="7198456"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30609"/>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="InParanoid" id="B7GBW4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="177" mass="19666" checksum="9DC6DF03D8E01D41" modified="2009-02-10" version="1" fragment="single">MSRQLSVSSLHAGQLRYHDFAKLRELYALGRASHYSTVARDTGIVRASGSKDQSIASAWKADVGPMHNTTRSFLTFGSSASSNPFTQLLRTQQLKRLESAANAAPQDGDTQYRFLYELAQDHPSAVIARIRHPAFKRHALNSSAATLYLQLLQKTNQVSQLDVDDILQRVSRGLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC29</accession>
    <name>B7GC29_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184645.1">
        <property type="nucleotide sequence ID" value="XM_002184609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC29"/>
    <dbReference type="STRING" id="556484.B7GC29"/>
    <dbReference type="PaxDb" id="2850-Phatr49851"/>
    <dbReference type="GeneID" id="7198673"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49851"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392561_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC29"/>
    <dbReference type="OrthoDB" id="47691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="703" mass="78758" checksum="D9836205F37D99A2" modified="2009-02-10" version="1">MAFRQHNPNVITPPNPSVSNKKDVGVIGEKEPTVRSEFIDKENIPPSFSPPMPPSVHGFHDVEMERLVRGVNRFGLNHGSDNPSRVEGSILGLAPAYPPAVVRLTSLKKANSAAESSEPLAQHRFNRSLWNRAGSNTTQQDSIKKLDVLGRGIRSPKRIPFGNVHHGGCDSARNDVKSAEIPPPRADFASIVRCNAPQSPNTLQDQHHQHLLLKEAAPKDPSIPAAVADAIKASRECRGTTKVATVEKAELYLRHAIAEYHAGRITEAPNGSCYNNIVHGYADLKEPAKAEAILHLMWSDFQQGNELAEPNVRIYTSVLYAWEKSKKESAPERCEAILQQMHRLHDSGIAKLCKPDLYAYTVCLHTWADSKRPDAPKRAEQLFRKMKDRYHNGDTELQPDSVCYVNLLNAYANSAIEYAHTEDLLWEMVDDFIAGNESAKPIIRNFNTVLAVWSKSGSAEAPERSEAIIRRLHELNKWGALDTKSDQYTYSLLLKTWTTCNRHNSAQEAEQALYWMESLHSEGDQGARLDVIKYTTVISALARSGNPGSAETLLEKMLEDYQKGNSKAKPDAKSFNMVLSGWSRYHNATVAAARAQALLHRMWNYRAVHIAPDTWSYNTVLFCWKNANGPKQGESLLLDMDRMAAKGFAKARPNSTSFQAVIDSWKKSNFPFKHQHIHQLQEESQKRFGESAKSKNMDSRSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC63</accession>
    <name>B7GC63_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184747.1">
        <property type="nucleotide sequence ID" value="XM_002184711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC63"/>
    <dbReference type="PaxDb" id="2850-Phatr49877"/>
    <dbReference type="GeneID" id="7198510"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49877"/>
    <dbReference type="eggNOG" id="ENOG502SE5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1047529_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC63"/>
    <dbReference type="OMA" id="MTSICCI"/>
    <dbReference type="OrthoDB" id="194331at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853222" evidence="2">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="266" mass="28620" checksum="1A7C275F2A3DB76A" modified="2009-02-10" version="1">MTSICCIILALGGTARSFHLEPSTRTSSLPSRSNTIASGRFSLLGRDNVKVPKRASSSLYGKTDDDWDLKSLLSLEKENASTEQRLGETNFGLAQLTSLTQPAQQILDGATSGWALSYANLSPDTEKSVPGVGFLATNMAYALAGLVLTLQGDLWFGLLTDVTAIASFNYHYNQLQVQGEMGAPVVRLALLVDYAFAALSILTASVYLFSSPSFPLEGLEYGAVSLVCLGLCWVYEEGRTYMILHGLWHLFSAYAGYLIGAAHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC90</accession>
    <name>B7GC90_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184680.1">
        <property type="nucleotide sequence ID" value="XM_002184644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC90"/>
    <dbReference type="PaxDb" id="2850-Phatr40725"/>
    <dbReference type="GeneID" id="7198604"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40725"/>
    <dbReference type="HOGENOM" id="CLU_1063412_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC90"/>
    <dbReference type="OrthoDB" id="513013at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="169" mass="19096" checksum="7C905555EB8C3F8A" modified="2009-02-10" version="1">MPGWDDKSDLETASPESVPSNFVESETNAWLEEKEQQQQSNDDADNNKNNEDDDDDIDDEEILDTHGNVPSEQLRQRLEMQWRVASHVQDDNCDVYQPHTCGGEPCQLCRGRGWNDCRFCHGTSVLWSRPSLATPPTSCKICHQGVETCAYCKGSGWIASWTDLQTSSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-04-10" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCG7</accession>
    <name>CYB5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">PHATRDRAFT_30770</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="226" last="233">
            <title>A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis.</title>
            <authorList>
                <person name="Pollier J."/>
                <person name="Vancaester E."/>
                <person name="Kuzhiumparambil U."/>
                <person name="Vickers C.E."/>
                <person name="Vandepoele K."/>
                <person name="Goossens A."/>
                <person name="Fabris M."/>
            </authorList>
            <dbReference type="PubMed" id="30478288"/>
            <dbReference type="DOI" id="10.1038/s41564-018-0305-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>INTERACTION WITH PHATRDRAFT_45494</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hemoprotein that functions as an electron carrier for membrane bound monooxygenases involved in sterol biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with alternative squalene epoxidase PHATRDRAFT_45494.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MH422132">
        <property type="protein sequence ID" value="AYI99265.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184806.1">
        <property type="nucleotide sequence ID" value="XM_002184770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCG7"/>
    <dbReference type="SMR" id="B7GCG7"/>
    <dbReference type="STRING" id="556484.B7GCG7"/>
    <dbReference type="PaxDb" id="2850-Phatr30770"/>
    <dbReference type="EnsemblProtists" id="Phatr3_J30770.t1">
        <property type="protein sequence ID" value="Phatr3_J30770.p1"/>
        <property type="gene ID" value="Phatr3_J30770"/>
    </dbReference>
    <dbReference type="GeneID" id="7198555"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30770"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_0_1"/>
    <dbReference type="InParanoid" id="B7GCG7"/>
    <dbReference type="OMA" id="VGHSPHA"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000446441" description="Cytochrome b5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="30478288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="30478288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="30478288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="133" mass="14590" checksum="A3F73A3F13A09860" modified="2009-02-10" version="1">MSAEKEYILDEISQHTTTESCWLIIGNASNGGPKVYDVTKYLDDHPGGAEVMLDVAGQDADEFFEDIGHSKEARAELKNYLVGNFKIDAATLAKMKADAEAKAQQKNSGTGIMLIVLMALFAIAYGYYQTQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD95</accession>
    <name>B7GD95_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185090.1">
        <property type="nucleotide sequence ID" value="XM_002185054.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr50194"/>
    <dbReference type="GeneID" id="7198887"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50194"/>
    <dbReference type="eggNOG" id="ENOG502QYMI">
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        <property type="component" value="Chromosome 27"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218:SF3">
        <property type="entry name" value="OS07G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="314" mass="35806" checksum="41751A07CC2F8193" modified="2009-02-10" version="1">MSIRATKRVKLHDNKNVSDRKQKSFGLDLPQSNILASLPEDLVCRVTNFLDARTLVAFGATCRSFHDLSQKNAAGWDNLCEVLWRSKVHVCAAARAHPSRKESYLRSIRDAQTRQSITIDELCYDIETRRGTIWSFRFKESAGDEWTNLDPWYYGQPCRKMVFLKDGTVQEFSGNTNRDNSNDSHDRMSAAPQLAPPLFDFGFERLAADNHPVPFLAAHGREGPRVRVGNDAVENLIDRPVNMTWRFLSRPMDLPPRPNGSYLRFNVGGRDVPTYVIRRSPTGNWGFVMESCWGLYGSFELPPQRISSAHQQRS</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185015.1">
        <property type="nucleotide sequence ID" value="XM_002184979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD98"/>
    <dbReference type="PaxDb" id="2850-Phatr50195"/>
    <dbReference type="GeneID" id="7198817"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50195"/>
    <dbReference type="eggNOG" id="ENOG502SX5W">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2066031_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD98"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="14345" checksum="8563753DFA6E6E36" modified="2009-02-10" version="1">MAKGRQGFYLEGWKFAIYLVIPITASWYFNDPERRKSSADYWKYIQYPANPNTNMKEQLEDLRKKQAQRQVYRDQMQELQAQAARSRQEVTEELDSNTKQSWWRWVPFSGRKESSPNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDC2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
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                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
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                <person name="Detter J.C."/>
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                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
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                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
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                <person name="Kaplan A."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
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                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CCAP 1055/1</strain>
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    <reference evidence="3" key="2">
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="7199000"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50214"/>
    <dbReference type="eggNOG" id="ENOG502RVW7">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="B7GDC2"/>
    <dbReference type="OrthoDB" id="35968at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057491">
        <property type="entry name" value="DiatomPyrShell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25192">
        <property type="entry name" value="DiatomPyrShell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="383" mass="41390" checksum="C43DA7982B467F33" modified="2009-02-10" version="1">MKIYGKLLAVCVFQTNVWGTNAFVAQKPKALAFKGTDSQWQTFSYVESLGGGASDPYSSGSKLASSEGASADKDVMDKRGVASGSPANVMEARLASLEKQKKSDSQSSSQSGPMSTKKIWDSTSSVTVQGGSLKTWSFPNPSVERVQVVMNTEGRPLDADIELWQGPDNTPYKMRVYVEDGSLRPFRAVIETPRGPNTIAIRNTGHLEFPLAAYVMAGSADNGFVAKTTEETIPRVIQGGALRTYPFDPTVESVQVALRTDGRPLNVRIELLQGPNNNKQVMELYTEDGMDRPFFCVIETPGSGNVVRVVNTATMEFPMTALVEAYQVSNGNSASNPVIGGGSGYMDRACAVRRIGPSEDYGMQGLQAEELKVTFTTLRSCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE68</accession>
    <name>B7GE68_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50461</name>
    </gene>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185385.1">
        <property type="nucleotide sequence ID" value="XM_002185349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE68"/>
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    <dbReference type="GeneID" id="7199312"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50461"/>
    <dbReference type="eggNOG" id="ENOG502SEN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640093_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE68"/>
    <dbReference type="OrthoDB" id="40186at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
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        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="429" mass="47221" checksum="CAF26182DC5B4342" modified="2009-02-10" version="1">MDQREVDEAEAQLARALGLSNFDSSSNDSRDPEQQFIPDPYAEQVDLSKLRGVASGDNKKVDDDSETDLEALAELVPDIKSRRKNTDSSGIEVGSHSHIPMPAQDQYKSSPALDEVIARADCAPPPSDEDSTDGRRLSMPSATDYLKHTVSTQANGSRNVDDVSKLSSMKGGNKDRTGHVYKPSKGPRVPADEDEEYDEDTLGEYPRSEHVLGEAENVSKDFMNPSSGQSISTATQTHEMRMPMFLPTFKPATGCTNASDFVVRCFVARLRSGITVVKHGRSRWCKSRLRVLHIHPDGRSLSWRPAEGEPTTNRRPPKLDLSTCLEVRHAWSPDPHNPVYTGTPILRQKCEAANAHKSFALIFKGRTVDITAVTADQCKVLMEGFSALCFRLQVANLAGRKKTRPMPEEDGISTTASNTLTNNSSAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEF5</accession>
    <name>B7GEF5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41518</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185479.1">
        <property type="nucleotide sequence ID" value="XM_002185443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEF5"/>
    <dbReference type="PaxDb" id="2850-Phatr41518"/>
    <dbReference type="GeneID" id="7199377"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41518"/>
    <dbReference type="HOGENOM" id="CLU_1630265_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEF5"/>
    <dbReference type="OrthoDB" id="6352234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="163" mass="18818" checksum="27A1FCAB243FEB51" modified="2009-02-10" version="1">MEQVQFKLHDGSRRAPSGGIEGLGFDNDPNKPKTKDPAVSLYTVPVQEILERYRAPPVMEYLSLDIEGAEYFVMKDFPFTTYRFKIMTIERPSQELVNLLYSNQYVYLAANNEYGMETLWVHRDHLSELDTTAIEAVKWRTVSTRWIEVGTSPAEKPRVIAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N2</accession>
    <name>B7S3N2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999261">
        <property type="protein sequence ID" value="EEC42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176166.1">
        <property type="nucleotide sequence ID" value="XM_002176130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N2"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1162"/>
    <dbReference type="GeneID" id="7204995"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1162"/>
    <dbReference type="eggNOG" id="KOG4621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_875691_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N2"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36053" checksum="C57990980C45A099" modified="2009-02-10" version="1">MSWKNWWRPSICRQDPPSASSTSLDGETRTLRSFDCELPDPDADSQLEEKAENAAVRDFDVKRAELLGIRRRRMLHRMEPQSTSDTFPHVCQGESWDCGIACIEMVYLWCCQSCRVDAFPLSAVRDWMVRFASTQSIWTVDLVILLQGLKDKLQLPINLLFCSDTLRVNTALAALDYYQSTFDKDRKRVQHRLQAVSKMNIPVHQGELRVDDLVAILSDDNAVAIVLVNNAMLIDQDVPGQLGRESCYTGHYLVLSGVSSNPQHVTACHDAWRENSPSWCFIAHNPASDEKVTFLNPVTLELAWDSIGTDHDIIFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3U7</accession>
    <name>B7S3U7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_bd420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS999275">
        <property type="protein sequence ID" value="EEC42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176237.1">
        <property type="nucleotide sequence ID" value="XM_002176201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3U7"/>
    <dbReference type="STRING" id="556484.B7S3U7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft420"/>
    <dbReference type="GeneID" id="7205061"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd420"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_4_1"/>
    <dbReference type="InParanoid" id="B7S3U7"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10292">
        <property type="entry name" value="GST_C_YghU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008731">
        <property type="entry name" value="PRK11752.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32996" checksum="CFF35744A6DA49B2" modified="2009-02-10" version="1">MSSSTSNEEYTPPKVWKYESSEGSKFSMNRPTAGPRFEKELPVGKHPIQLHSMATPNGQKVTIMLEELLAAGHDAEYDAYPIKIMEEDQFGSGFVAINPNSKVPAMSVSQEGKEPLRIFESGSILLYLAERFNAFLPADKRTETLNWLFWQMGSAPYVGGGFGHFYQYANVKNKYAIDRFTMETKRQLDVLNRQLEHNKYMVGDEYTIADIAIYPWYGWLVLGQGYGDAATFLNVEEDYPHVIRWAKMIEARPAVQRGSIVNKFWGDNEDAQLLERHSADDFQKTTAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7S436</accession>
    <name>B7S436_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_bd714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176330.1">
        <property type="nucleotide sequence ID" value="XM_002176294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S436"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft714"/>
    <dbReference type="GeneID" id="7205100"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd714"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267815_0_0_1"/>
    <dbReference type="InParanoid" id="B7S436"/>
    <dbReference type="OrthoDB" id="38501at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="42"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="333"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="615" mass="69472" checksum="21C01E538BF2E2CF" modified="2009-02-10" version="1">MAPRDTVYDHNAESMDKRYDSSRNADLIADAGKVHMDKPQMWGKGIISDVKRTVLTHWKDEMINLNQKTIAVTLLLFISVIAPTLTFGAVYGKVTENRIGAIETILATAWVGCTYALFGGMPTCIIGSTGPVLAFSTVIYNMSDSLDIPFLSFNAWISAWLFGYCLLAGFFDLTRFVRLATRFTDEIFALLIVSIFVMDAIGDPFSDVGILRYLAPRHPSHEDFEDDPDYDFKTTGLLSVILGLGTTSLIFFFRSFKFSPFFCNQGIRTSVHDFAVTASVVIWTLVKELLFDNVDTEGLNVPERFEPTFACCDASCLTFFPDDCLDQAAAAGTRSWFVDFSDLNGKAWAPFLAAGPAVLAFVLCFLDNGITWHLINHKSHNLQHGEAYNYDLCLSGFFNFVNGMLGLPWLVATTVPCIIHLNALADKDKDGKFLSVQETRLTPLFAHLLVGVSILALDVLKLLPLPVLYGVFLFMGLSSLPNMQFWNRFLFFFMQPSEYPETVYTRYMSKARIHKYTLFQIFFFALVFIVQNFKVIAIVFPLMTLLCIPARLFFLPRFFEGWELLLLDGEDEAISQWEEAKQRSMLSEDELRMATKHDMKIDDGEEDEESSEDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4E1</accession>
    <name>B7S4E1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_bd1749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176435.1">
        <property type="nucleotide sequence ID" value="XM_002176399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4E1"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1749"/>
    <dbReference type="GeneID" id="7205167"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1749"/>
    <dbReference type="eggNOG" id="ENOG502SQU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432456_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4E1"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="322"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="633" mass="69854" checksum="75D199EFC02B42B1" modified="2009-02-10" version="1">MDSNLECTAKPISSDGNVSRRETGLVFGQGPTAPKAAEPDAPFPPLPGRYQKQLLRGASVGSLRPNRDRENYGRRTRSTSLGMNGFRDLQLDVREYRGESKNEQLDGTHQRPNPVDEETLLNLTKQDKAASREATVTEMAQYRSIRQTAVVSVALMLVLQTVTATSLVRAGDVSIDEAILFTMYSVTTAGFGSVDIPFTPGFLLYLVVYMLVGIGLTTVLASQVYLYVALVTRISKSSVDQRELADRGLNNWTQAKAQGSNEENSEDENDAPAAVPHVEALKDDRRHGHLNIGQVSLSLVDRLKLFFRSSEATRCFCLTCYLVGLLLIGVIGMMSLEGWTFVEALYFSTFVMTTVGFGDYFPTKSSSIWFVIFWLPFNISFLSIFMGNLGRYYMMLSSWNVIRKEKKLRKIYGFTTPLLGEEGPSRQIADEKYQIQRHGMSATELDCIQTMGDVVRFVLGTLAADVSLLDDKSNPVSSIGALLETFMLQSSLSHPGTFEKNGVRKPSFALMVLVQERFAHIIANDIAGFHSDLCVKDTTVSMTVESIQEVANQWQVPAGALTAFRAVAFEALIFVGEKKLVSKGAEALLNLSPFEFHEIFSPLLAALADSGTMEGWLAVTTPTAAEKFPRSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0B9</accession>
    <name>A0T0B9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem I reaction center subunit II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">psaD</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="5"/>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Plastid</location>
            <location evidence="4">Chloroplast thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PsaD family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874394.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0B9"/>
    <dbReference type="STRING" id="556484.A0T0B9"/>
    <dbReference type="GeneID" id="4524680"/>
    <dbReference type="InParanoid" id="A0T0B9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003685">
        <property type="entry name" value="PsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036579">
        <property type="entry name" value="PsaD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31982:SF5">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31982">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT II-1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02531">
        <property type="entry name" value="PsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64234">
        <property type="entry name" value="Photosystem I subunit PsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2 4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABK20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="139" mass="15567" checksum="67C35E7A11929D16" modified="2007-01-09" version="1">MTLNLQTPFPTFGGSTGGWLRSAEVEEKYAITWTSPKEQIFEMPIGGAAIMRSGENLLYLARKEQCLALGTQLRTFKINDYKIYRIFPSGEVQYLHPKDGVFPEKVNPGRTAVNNRDFSIGKNPNPASIKFSGINTYES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-04-09" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0H4</accession>
    <name>SYFB_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit, chloroplastic</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0H4"/>
    <dbReference type="SMR" id="A0T0H4"/>
    <dbReference type="STRING" id="556484.A0T0H4"/>
    <dbReference type="InParanoid" id="A0T0H4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000277248" description="Phenylalanine--tRNA ligase beta subunit, chloroplastic">
        <location>
            <begin position="1"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="300"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="612"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <sequence length="706" mass="81082" checksum="C73614BC814A04C7" modified="2007-01-09" version="1">MQISLKWIKELIDIENVDLDDLIEKLTLGGFEVEEILELEINNEKQIALEISSTANRSDSLSIQGISVEIASLFNKQPKVCKYFNSSLNWQQKIKNLTTIRTSKTECLMFTAVILEGLEDLTVPKWIQNKLVSSGIMPLNNLVDFQNYILLETGYPFAFYDLDKVYSKVRTPTFSLSIEKAENGSEFFASNQINYKLDNSIFLVQANNIPISIAGIIENDEIICHSKTSSLLIEGSIFSASKIRQQSRKLAIRTDRSARYEKSLKSTYLIEALYRLISLLRISNPSLVYKFHSSNKVLEKVLKPIVLNYKTIVEILGPIKKRTNEHLIYISPETVTDYLKRLNFKFLFDSSTLNWEVTIPSIRSDDITREIDLIEEVGRLHGFNNFLTMLPQIKSVGRADFSYQTRKKITSYLLNMGLTELIHYSLVSNETFLKNEIKLVNPLLSDCSTLRVSLLPSLLMTIQENLKQGNSILEGFEYGHVFSGNIETTLTEIEYVGGIFGGTKIKSSWFEKGQSLKWFEAKGKIEKLFQQLNLGIHWRINSQTYTKKFLHPYRSAEIFLSSGKNIGVFGQLHPLLANKLGLSSEIYLFELNLELIQQSLQQNKLTIYSQYSVYPKIVKDLSFIIKKNIKFDELEKIIYANGTEFLSQINLLDDYKGEFIPEKHTSLCLQLTFQSNKKTLENKEIDRIVKNLKRVLELKVQAILRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3B0</accession>
    <name>B5Y3B0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185617.1">
        <property type="nucleotide sequence ID" value="XM_002185581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3B0"/>
    <dbReference type="PaxDb" id="2850-Phatr46642"/>
    <dbReference type="GeneID" id="7204480"/>
    <dbReference type="KEGG" id="pti:PHATR_46642"/>
    <dbReference type="HOGENOM" id="CLU_1032311_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3B0"/>
    <dbReference type="OrthoDB" id="45313at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032751">
        <property type="entry name" value="Fuseless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270:SF2">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15993">
        <property type="entry name" value="Fuseless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30064" checksum="99FD2A317E6523A1" modified="2008-11-25" version="1">MALSSNKAGLAGSRRRRRILKGVQVPLLRSFMLLLVVWFFNDTPSVISAFTPRRSCTAWHRSSYSLPRPLLSRNEFVLRKIQVKVDNEAPSRVEDLPSTVPFRSSSYIRSFLWTYGPYGASAVLVWRGIWDLQDIYLFPDDLITSSLLSAAIGITFGTVAFFAQHVLNDTVKTVLVAVASISYWRGVWILWDELVWPQDPTLQSAAGLAVGSAVLLAAKSFRLGVASPPILHQNDQIYLLEDPFLGPAHAAFDVAHQEEEVLHGVDGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3D3</accession>
    <name>B5Y3D3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_46662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185630.1">
        <property type="nucleotide sequence ID" value="XM_002185594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3D3"/>
    <dbReference type="PaxDb" id="2850-Phatr46662"/>
    <dbReference type="GeneID" id="7204583"/>
    <dbReference type="KEGG" id="pti:PHATR_46662"/>
    <dbReference type="eggNOG" id="ENOG502SPCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1450311_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3D3"/>
    <dbReference type="OrthoDB" id="195904at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841092" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="187" mass="20338" checksum="0B45514FD21625C6" modified="2008-11-25" version="1">MVLRIHTLVPLLSLVLPTLGRAFVAQQVPSRLSARAFPRLFASEDWKIEIDMPPVGSGIKAYMKILPILSVPSEIVQVRYKVPFGLNVEPKKSLAVCTKDGPGGEKVGDVLRYTTQWTLGLPAGDGLVTTAASFAGGLSWQCSMFDVMNAKAWEQVVEALVSNVDTKTDEVVLLFERPLEGTAPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3V1</accession>
    <name>B5Y3V1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMC6</name>
        <name evidence="14" type="ORF">PHATR_28237</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185720.1">
        <property type="nucleotide sequence ID" value="XM_002185684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3V1"/>
    <dbReference type="STRING" id="556484.B5Y3V1"/>
    <dbReference type="PaxDb" id="2850-Phatr28237"/>
    <dbReference type="GeneID" id="7204555"/>
    <dbReference type="KEGG" id="pti:PHATR_28237"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3V1"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="13">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACI65190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="24089" checksum="2070A2FC45788095" modified="2008-11-25" version="1" fragment="single">MTPSIKKRSSEASELDAEAAVPKRQATEKENQADPNAGVEDDVAETLASPKKAINVVGQPPEAGIIKEVYVENFMCHPKLRVTLCRNVNFIHGQNGSGKSAILAAIQICLGASASRTHRARNLKGLVRKDAGPNATAKVRVTLWNQGNDGYLPETYGDSITVERTISLRGGYNGYKLLDHNGKERSRNKKDLHEMLDMLNIQVENPVAVLDQDEAKKFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4F1</accession>
    <name>B5Y4F1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_43818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185999.1">
        <property type="nucleotide sequence ID" value="XM_002185963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4F1"/>
    <dbReference type="PaxDb" id="2850-Phatr43818"/>
    <dbReference type="GeneID" id="7204258"/>
    <dbReference type="KEGG" id="pti:PHATR_43818"/>
    <dbReference type="eggNOG" id="ENOG502SZ2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_875685_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4F1"/>
    <dbReference type="OrthoDB" id="56881at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37898" checksum="DB37FA39C82AA4C3" modified="2008-11-25" version="1">MGNISLWFRMYGLPLTLLICFLLLALTSDLKVFRNLPLPNTTTVVRSGLQTKSQTTQNTPNLVQEPFDRLSFLSWELHEGFPRSHQSGRPRLLIAQTISNFYAPLLDAGQPVNQAYARVYGHDYVVARGIYLVNERINETQLTAPDSRASYNKIALLSYALREGKYDKLLVLDSDAVISDFDIDFATFGLDPEVMLFAQAVDPSKAVNYWDINNGVTLWNLHHGLFVPTWYEWYSRSMKNVYRGNNDKDQGILHSILRQMPNESRPVRRVKHFCCYRGALIQHFIRKNTTDFMVLAKSRLENLKADANYTLEYYTTLINQTINQSALTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4M0</accession>
    <name>B5Y4M0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186315.1">
        <property type="nucleotide sequence ID" value="XM_002186279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4M0"/>
    <dbReference type="SMR" id="B5Y4M0"/>
    <dbReference type="PaxDb" id="2850-Phatr33198"/>
    <dbReference type="GeneID" id="7204290"/>
    <dbReference type="KEGG" id="pti:PHATR_33198"/>
    <dbReference type="eggNOG" id="ENOG502RW8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1285504_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4M0"/>
    <dbReference type="OMA" id="ARWEWSA"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24426" checksum="528F4165B4C2E8B0" modified="2008-11-25" version="1">MGLIHTPRTIVSIAKGLWKRRQGTVDWPGLGPDKPYVYNARLGLFDVDYLGHLNNAAYLSHAELARWELTAANGMLTSMLQSGTNFIVSGSCIRYRQEIRPVFRKFQVDTYVAGLDQRTIWMVQNFRYPGQNERIRAQMIVQGVAVQKTKGIIDPRSFFVDTVGMPSDLIESVNLPITSDDTVEDVLERYSFLEKALRRAATVDDELQKKEANKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4V6</accession>
    <name>B5Y4V6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_18551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186362.1">
        <property type="nucleotide sequence ID" value="XM_002186326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4V6"/>
    <dbReference type="STRING" id="556484.B5Y4V6"/>
    <dbReference type="MEROPS" id="S10.005"/>
    <dbReference type="PaxDb" id="2850-Phatr18551"/>
    <dbReference type="GeneID" id="7204375"/>
    <dbReference type="KEGG" id="pti:PHATR_18551"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4V6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="471" mass="53282" checksum="76CB0096EC85D247" modified="2008-11-25" version="1">MSTTVMGKSIFAIGAFLTASLYNFAAYKKETPSDVRVHLAVQERTASAEDDRITMLPGLDYDPGFEQFSGYLDVSATRHIFYWYMESQSDPANDPVVLWTNGGPGCSGLLGMGAEHGPFYISKSGRLHDNPYSWNKVANMIYFEQPAGVGFSYCDAAEDYITGDEQAAADNYNFIVEFLQRYPERQTNDFYVSSESYGGHYIPQMTLEILRRDIDHFVNFKGFLLGNPYVDPLSNMVTQFEAYYSHGLIAKPLFDDWSKKCKDSNYWMSRECDQITTNMFKQFGHGINPYALDYPVCKKDAAEYSHLERPVSNPAFKPCSQEFLENYLDREEVRDALHVAPSAKPWDVCGGVRYSKSDVDIPTIGLYQELIDQAKAGKHDLNMLIYSGDDDSICSTAGTQYWLWDLAEASSIWKAWQAQEQTSGFVTTFDLGDKTNATFTFVTVHGAGHEVPSYRPVEALEMFRRFLAHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y573</accession>
    <name>B5Y573_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_44050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186418.1">
        <property type="nucleotide sequence ID" value="XM_002186382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y573"/>
    <dbReference type="FunCoup" id="B5Y573">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y573"/>
    <dbReference type="PaxDb" id="2850-Phatr44050"/>
    <dbReference type="GeneID" id="7204007"/>
    <dbReference type="KEGG" id="pti:PHATR_44050"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_3_2_1"/>
    <dbReference type="InParanoid" id="B5Y573"/>
    <dbReference type="OMA" id="EHMGSKD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="125" mass="13375" checksum="22939213B356B890" modified="2008-11-25" version="1">MAESGTGIQELMAAETRASQIVAEARIGRGDRMKQAKVEAQQLIDSYRAEKQEEFNNMALSQGGSEGNAAAALQAETNKEVQAMEGLFQKNVQGAVDVLLSKCCEVSLEVPTARVRATQKMAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y579</accession>
    <name>B5Y579_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186421.1">
        <property type="nucleotide sequence ID" value="XM_002186385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y579"/>
    <dbReference type="PaxDb" id="2850-Phatr33412"/>
    <dbReference type="GeneID" id="7204010"/>
    <dbReference type="KEGG" id="pti:PHATR_33412"/>
    <dbReference type="HOGENOM" id="CLU_861844_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y579"/>
    <dbReference type="OrthoDB" id="411867at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="35970" checksum="3054D1AF4B9FBF5B" modified="2008-11-25" version="1">MNADANRNTTSISSSTNSDAVDGEASSPVAAVPRKQLQHDSASFLRENVKAEINKQVVRHKLAKLRHLVIPQAINAAYLDSLFPDLLQSFDPQTVTYNGGVANVTNWKISCYLEVMEGGIPCTTPNETLLELFRPVLNTCNDLFLHWYRQQHACNARARRWTSSVAENAPSMQSCYRLMTFVTRYTPNPGEQALLKHVDGAGKVDGSVVLALPIDKWSAPEEVNTFVGGGLTFWDGKNNANSTQDASTQPREIHYDTRSGDLAFIDRSDETARKRYLSPTSQGFNTVVCFSDSLSMIRRAVWHQADPITKGTRWALVIFYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5G6</accession>
    <name>B5Y5G6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_44136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186182.1">
        <property type="nucleotide sequence ID" value="XM_002186146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5G6"/>
    <dbReference type="STRING" id="556484.B5Y5G6"/>
    <dbReference type="PaxDb" id="2850-Phatr44136"/>
    <dbReference type="GeneID" id="7204053"/>
    <dbReference type="KEGG" id="pti:PHATR_44136"/>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459661_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5G6"/>
    <dbReference type="OrthoDB" id="187447at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF151">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF9, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="458" mass="52603" checksum="4801F0B3839EF978" modified="2008-11-25" version="1">MERLTEGDRNALSLEDLSSISTNVSYFYLKNELGLSEEAMWKITYEAGSALGMTTNTIRRKVEVLRDTMSLSDAEIISVLERHPTILHLSADKNISPTILFLLRMLELGRDDLRRLFVSEPSILSYTTANLNSKINFFVRIMGYSIGECRKVLLAEPKLLRVSVRTGLVPRMRFLVRDMEIPMQNLRAIVKKHPRILLYSLDDNLIPKLIFYLIMTLHMELDQVQKLLVTYPTILEYNLDRHILPITEFFVKDLSYQPAEFRSILLKFPRLMTHSLRKIKHLVGYLRFELGLTGSQVKRVLYQAPQIIGLNTDVSLKAKVEFLRDSLNLSDHELRRVVSGMPTLLVLSIDGNLRPKAEYLRNCFDGNEKDLRETILRLPTLLGYSLDKRIQPRMTAILQSELKAGSITVGIPMKEDKFDAWLVGRKREMKQGLARAEGKALPAIPDLSGRIVHWTRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5V0</accession>
    <name>B5Y5V0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_44247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186529.1">
        <property type="nucleotide sequence ID" value="XM_002186493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5V0"/>
    <dbReference type="PaxDb" id="2850-Phatr44247"/>
    <dbReference type="GeneID" id="7204074"/>
    <dbReference type="KEGG" id="pti:PHATR_44247"/>
    <dbReference type="HOGENOM" id="CLU_1032372_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5V0"/>
    <dbReference type="OrthoDB" id="78715at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31420" checksum="22726A08467726C5" modified="2008-11-25" version="1">MSIIIGVIIAFGIRATTWIFNLQKRSHQGDYHKVFNGENFVAWWKDQLLPNLHQHSFIHMDNAVYHKLYGNHAPKWGKLRKQECIDFLLLKGIEVEARCPAVVVKARTKEWILANERFECVRLAEEQGHKVLFTPPYHSDLQPIELTWARIKGNIGRQYSVGTTLALVHERLLHEFKNLEESGHGAIQGMINKCVRIAKTFYDNMPEEELTEEALEDEEDDDYDDYEAGFDAGVPPENTLDEIVVEEELEDVIFAANKDVAMENEDIEDVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP96</accession>
    <name>B7FP96_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_9427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177178.1">
        <property type="nucleotide sequence ID" value="XM_002177142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP96"/>
    <dbReference type="FunCoup" id="B7FP96">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FP96"/>
    <dbReference type="PaxDb" id="2850-Phatr9427"/>
    <dbReference type="GeneID" id="7196111"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9427"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_2_1"/>
    <dbReference type="InParanoid" id="B7FP96"/>
    <dbReference type="OrthoDB" id="39912at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852492" description="UDP-N-acetylglucosamine transferase subunit ALG13" evidence="8">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="123" mass="13188" checksum="FD4C816971DC6CE1" modified="2009-02-10" version="1" fragment="single">MSGTIFVTVGTTLFEALIQAVSTDDALQGMVENGYSSLVIQYGKGAKPPILSSPSLNVEVYAFKPNLTSDMKAADLIISHAGAGTVMEVLRLKKRAAVVINTMLMDNHQTELADAMGERHHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPX7</accession>
    <name>B7FPX7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-guanosine(34) queuine transglycosylase</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_17628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176787.1">
        <property type="nucleotide sequence ID" value="XM_002176751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPX7"/>
    <dbReference type="FunCoup" id="B7FPX7">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPX7"/>
    <dbReference type="PaxDb" id="2850-Phatr17628"/>
    <dbReference type="GeneID" id="7196529"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17628"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="InParanoid" id="B7FPX7"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="42520" checksum="52F929F7BB31050D" modified="2009-02-10" version="1">MFMPVGTKGCLKGLAVQELVTDPALSCPIILGNTYHLAIQPGTELVDEMGGLHAFQAQPYNLLTDSGGFQMVSLVKLSKITEEGVSFQNPFQKHTNADDVSSMLLLRPEDSIRHQNNIGANIIMALDDVVSSVMEDEARFVTATHRTLRWYDRCVAAHAKADTQNLFPIVQGGLDIALGGKREQCLAGFRHRAVTQGYCIPGYAIGGLAGGESKDDFWRVVDHCCRALPDDKPRYLMGVGYPLDLVVCTALGCDLYDCVYPTRTARFGVALVPGRHPGTLRLKAHECASDTGPIQDGCGCQACREGISRARLHLLLKTNNPLAAELVTQHNIAYMMTLVRDMRNSILRNEFAAFASNFVQQQFPGERQGGDECPAWVKNALEAAGVGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQC9</accession>
    <name>B7FQC9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176852.1">
        <property type="nucleotide sequence ID" value="XM_002176816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQC9"/>
    <dbReference type="PaxDb" id="2850-Phatr43021"/>
    <dbReference type="GeneID" id="7196828"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43021"/>
    <dbReference type="HOGENOM" id="CLU_1172638_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQC9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="237" mass="25630" checksum="C9112CAED6B61D45" modified="2009-02-10" version="1">MDNSSSQNPPLTESPSSTQNESNMVLPAPSDFTLPTNSPSALMTFLPPSSGSLNDAAVSPGPATLRPSVGRPAVSLAPTLPPDGSVPHQIPTPPEHDVKNDTFQPQIPQDLKDPTSGDSPFCSSNQVSCMYGSHPFAFVLTSLVLLLFACWQWKFWCCKDTRDFSRGEYRAVTARYTDSAFADDYSVEENQEYLSDEDDGDGYGGWNSNGGGKHVIEMKDLGIEGKSDNLTLEEMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQS5</accession>
    <name>B7FQS5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176920.1">
        <property type="nucleotide sequence ID" value="XM_002176884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQS5"/>
    <dbReference type="STRING" id="556484.B7FQS5"/>
    <dbReference type="PaxDb" id="2850-Phatr43143"/>
    <dbReference type="GeneID" id="7196750"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43143"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQS5"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="20769" checksum="BBFD9564C975691F" modified="2009-02-10" version="1">MTDLFPAGASAVDTEDEGTLVDLNSKIESSECYGRNEAAGFPMTNLFIGDSRLGCKSDADEQLIIHVAFKEFVKIRSIKLTEYNNGMDPECNPSKIHIFVNRTNIGFEDWEDVDPTQTLHLTTEQLKESADPISLKYVKYQRVKNLTFFIEDNQGGEVSALGGMKLFGKPVQTPKMSDFNKSKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR20</accession>
    <name>B7FR20_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CYCP5</name>
        <name evidence="3" type="ORF">PHATRDRAFT_43226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176969.1">
        <property type="nucleotide sequence ID" value="XM_002176933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR20"/>
    <dbReference type="STRING" id="556484.B7FR20"/>
    <dbReference type="PaxDb" id="2850-Phatr43226"/>
    <dbReference type="GeneID" id="7196950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43226"/>
    <dbReference type="eggNOG" id="KOG1675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498283_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR20"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="392"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="547" mass="60285" checksum="F9035A3293D895EE" modified="2009-02-10" version="1">MGRRACVTPCLETSCTADTHTNNPSTPKLSSAPDTPNSLVDQDVSIRSVLQFAHQHTQRADSQGMKLQAPAEGSGPPEDSIEDSSLPRGDVESLRESQTSAPSLSMQFPGAQLSTTDNVGIPTDGGRVSDSVSSRCIPSRASHTRYAHTNAPQTPATVPEIQAQTPQQLYPDTAALIRTNNEAAFPHDVSNLSIRDIFNENTSNHQDYYGVDDPTASWTYSDACAIPYGTDRHHTENDNRGMATPPSTLHTPVAPLCSPDEDSSTGLPLPPPVITPSTPTAESVGGSVVTLASSTSSMQPQSARSKPVLYSAIGSLEDPNSTSFASWRDKKSWRNRPKIDFPSTHFLKPVNSVNCVTTQSHRPVSSSGMVYGLKQIRHVYEIPTEAEIYEFGHQLFKTVQLSSECSIVCLIYIERLMELAKVPLLASTWRPIFMCGLLLASKVWQDLSSWNIEFASVYPQYSLSAINRLEHTFLRMIKWELYISSSSYAKYYFALRSLTEKSDFRQRYNRMVGGVNCVQAAEARKIEQRSTQVKEEALLQLSRSWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRU9</accession>
    <name>B7FRU9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHATRDRAFT_9947</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177863.1">
        <property type="nucleotide sequence ID" value="XM_002177827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRU9"/>
    <dbReference type="PaxDb" id="2850-Phatr9947"/>
    <dbReference type="GeneID" id="7197380"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9947"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="B7FRU9"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF49">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC50677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="47890" checksum="B9B97CFA9595E600" modified="2009-02-10" version="1" fragment="single">AALNSCNLGYDVGVSTSVGRLVEKDFGLTRIEREIFIASINFWAMFGSLAAHYFTDTYGRRKTFFIAAVGFIFGLLVTASATSFNVLLLGRLFVGLGVGIGLAIDPLYIAEVTPARFRGELVSWAEVALNVGIVLGFSTELILARLPTGMEWRVMVLLGCIFPTTMMIVIGLNIMPESPRWLVANKRQAEAKQVLERIYPAGYNVDPVVEDIQEALQREELAEKAVGWSMVFHPTPGFRRMLLVGIGTVVAQQAVGIDAIQYYLLDVLDQSGIDSATKRGMVLIFLGLLKLIFAWIGGKLFDGQGRRKLLFTSLLGMMVALLIVALSFFLDSGSSASLTITGLALYISFFSVGMGPGGWLVATEVFSTSIRAKAMSLATFLNRVTATLMASTFLSTANLLGWTGFFLLLCGICLVTLIFLYVFLPETKGRSLEEMSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSE7</accession>
    <name>B7FSE7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_32710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177651.1">
        <property type="nucleotide sequence ID" value="XM_002177615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSE7"/>
    <dbReference type="PaxDb" id="2850-Phatr32710"/>
    <dbReference type="GeneID" id="7197188"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32710"/>
    <dbReference type="eggNOG" id="ENOG502SR6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034609_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSE7"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="421" mass="45862" checksum="0A5265720E95E2E5" modified="2009-02-10" version="1">MSVHQGISVCHVRVAVPGLAWGAVSQEATVWHPSVEKRRIASVERRDFYLETMIPSSSSSSSSSAGQAYVLYVDQYQHPAPLSDCFVAATTTSTVPINTASVSTDGSSLSSRQQSVWALSTSIPRFPKTTTTRTVDSAYCGQCLKFYDASTAVTTLGNKCPQNVTCQQCPLCLAAVTPTVKMTLSDSRVYYYHCNVCQWHSQHSCSVSTDSLSTTASTSTTARDLATLAVALERARDHNDNQNDPRGSYAADVQAHFASCVQAWSTMDSLKRGRQLSASTPTTIATPPSIVPLTMQDTDITTDTLLPCSVSDGALSTIAWQMQPCVVRRRQHDRNVALSSKLLPLPTTLRFRWSLRSVPELEESRPGILVKPKLNPLEGDSSLRTGHTQWWKKDASALHSSVTGCRDRPNSPFWCGSPILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSH8</accession>
    <name>B7FSH8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal multifunctional enzyme type 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177667.1">
        <property type="nucleotide sequence ID" value="XM_002177631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSH8"/>
    <dbReference type="STRING" id="556484.B7FSH8"/>
    <dbReference type="PaxDb" id="2850-Phatr43519"/>
    <dbReference type="GeneID" id="7197560"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43519"/>
    <dbReference type="eggNOG" id="ENOG502RWGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671751_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSH8"/>
    <dbReference type="OMA" id="ALEMWIL"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="361" mass="40151" checksum="7092D6AB8210C2E3" modified="2009-02-10" version="1">MISDDFTVSFNARDSILYALSIGFGSSLERYDEDRRYVYEEDINFAVVPTFAITFTFWANQYRRSIGDIPPFPPPLMSSAGVLPQGCLRNGASIDDLPIIQTEISVVFQNALPVPKSGQTEPMRVSQSFVSVSPKSIGTFVTTETKITNNCHTLCTITSTALVLGVPSSHVNPMQPTDMIREEQHPSKDALHELLVEWDYTVPPNQTLLYRQTSGDSNEIHVNPDALPATLEKQASKIRVDPDSQPDVQKEQDRDDSSRRKLRLHGLSTLGIAVRALIHYTEDNYPGSSLQAVKACFTYPAFVNDRITVKISGAKNDSSLQLGKSVFTFLVLNKTSGKVLLKNGYAEFAWNRSTLQQQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSU1</accession>
    <name>B7FSU1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_43604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177725.1">
        <property type="nucleotide sequence ID" value="XM_002177689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSU1"/>
    <dbReference type="STRING" id="556484.B7FSU1"/>
    <dbReference type="PaxDb" id="2850-Phatr43604"/>
    <dbReference type="GeneID" id="7197479"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43604"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="InParanoid" id="B7FSU1"/>
    <dbReference type="OMA" id="NYPWIHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855282" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="548" mass="59244" checksum="BA9AF4430B82A028" modified="2009-02-10" version="1">MIYRSALVVLSLMWAVTAKDYDFIVVGAGSAGSIVSSELVKSGADVLLIEAGGDNTDPAIDSLRSYFDLAFGALFNPFSGFKWIQWGYFSTEQTLAGAGAGATPKTFGIPRGRVLGGSHSINACAYVQANADDFNNIAAEVNDNMWRWRRTQRLRNKLERTIGITKLGKTQTGALDFIATAHEVLGFPFNSNPTQGDQYGISPSFWTGQESSEGGIRTTAFDAFVLPVLNSSNRKGTIDVVTFHQVQHLIFDENDSTKVVGVSTMNVRSNVATEFRALKEVILSSGTYNTPQILMLSGIGPQAHLNDLGLATKIDLPGVGSNLRDHYSVATFWDLKNLPEGAPFLFQSPSLNMFGPEQQGQPSFQFELAGNFGSVVPLRQVSTGTVRLQSSDPMASPIIDPNVLSTSSDVDNMVDGLENYLLPFFQGLIDKNLVTTNSLSPSASAEEIRQYVIERFDTNHHPVGTCKIGSSSDPMAVVDSNFIVRGTANLRVIDASIFPEVPSGNINGPTMTAALLGARKIKLAHRSSMTLDADDEEEDDGNHVRKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSV5</accession>
    <name>B7FSV5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHATRDRAFT_43615</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177732.1">
        <property type="nucleotide sequence ID" value="XM_002177696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSV5"/>
    <dbReference type="STRING" id="556484.B7FSV5"/>
    <dbReference type="PaxDb" id="2850-Phatr43615"/>
    <dbReference type="GeneID" id="7197335"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43615"/>
    <dbReference type="eggNOG" id="KOG0799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347985_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSV5"/>
    <dbReference type="OMA" id="YFVECDD"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852595" description="protein xylosyltransferase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEC50546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="811" mass="92356" checksum="67540337CC3DB650" modified="2009-02-10" version="1">MQRTIAFWALIVVLLFISVHAEQVPVGPPEALSSKTEHQHFQRLLQSSWDEIDFTDIDSHKAARSGLDQLVKDGSHMELRWAKMFEKAKTPECRAKIATHFGYFYNAIASEQSMPFSTAKFENKCPEPFYDWENLPPDMHVGHVQNRTYQPPRENATYIDDPKDLRFLYAILTHGEWHSTIRLIETLYEDGHVFVVHVDGKENSDETYKALQKYAATRDHVHVLGSSFRVRVNWGGFSMVNATLQILQYSFNVNGHCSRQRDPLVFDKVIHLASSSYPLATRSEIRQRIASFPLDANFLHVIMKPTRPSPDVWHYFVECDDSLHRIYRLNPLNNHTNGMELFTSSQWFIISREFAEYLARAEAGTFVHQYLDYIEHVVVADETFFGTVLRHTPFCLKHHNRNFLHLQFDRWESELPSNDRDPRKCMMLDPNHCGRSPTTLTADYADILELSDDLFARKFVEHISDFEGKSEEEVPEHNVKDIVDDWRKRRGTSKQGSNSSTTLSGQPQMTFEGHGVLLVARETLGIDGGDRQPVPLCLGLGETGNNLHLVPCFHDWVIPTLAPNWEFGAVIEAETIPHNRWEMQPCTSDGHLERLDSGEIEVTPGNYSITGPRCMLKMMEGIRAGRCFDGDSGNSQPGGEVQVFPCVHRWVQFLSVGDGRLAPKGSLFFTIPLHIVRQIHRMGHEQSPHMCLGVWGRGNKDEVDWKDESQAFSQERKENPVDGWKPLSEWEGEELFSTQCSNVGAVVEWIFVPFIVEDNLSADDGTDIDATTDADEVMFGPATTTEDTMNTAHETVIDDNGAAPERIGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSX7</accession>
    <name>B7FSX7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GMD1</name>
        <name evidence="6" type="ORF">PHATRDRAFT_25417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178058.1">
        <property type="nucleotide sequence ID" value="XM_002178022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSX7"/>
    <dbReference type="FunCoup" id="B7FSX7">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSX7"/>
    <dbReference type="PaxDb" id="2850-Phatr25417"/>
    <dbReference type="GeneID" id="7197497"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25417"/>
    <dbReference type="eggNOG" id="KOG1372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_1"/>
    <dbReference type="InParanoid" id="B7FSX7"/>
    <dbReference type="OMA" id="HWQTVNY"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="363" mass="40991" checksum="C6A2C76D6975C265" modified="2009-02-10" version="1">MSECEGRVALVTGITGQDGSYLAELLLDKGYTVHGIVRRSSCFNTGRIDHLYRDRHDTQVKLFLHYGDLCDASNLITIISSVKPDEIYNLGAMSHVKVSFDMPEYTADCDGLGVLRMLDAVRAAGLEQSVKFYQASTSELYGKVQEVPQSETTPFYPRSPYAVAKQYAFWILVNYREAYGMHLTNGILFNHESPRRGRTFVTRKITCAVAAIKEKQQKTLYLGNLDAKRDWGHARDYVEGMWMMLQQETSDDYVLATGETHTVREFVELAFAAVDITVKWKGEFGTIDEIGVDADNEDHILVKIDPRYFRPTEVELLLGDPTKAKEKLGWTSSTPFPDLVKEMVKEDLAMVRGTSVDPEKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT04</accession>
    <name>B7FT04_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_9794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177753.1">
        <property type="nucleotide sequence ID" value="XM_002177717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT04"/>
    <dbReference type="STRING" id="556484.B7FT04"/>
    <dbReference type="PaxDb" id="2850-Phatr9794"/>
    <dbReference type="GeneID" id="7197363"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9794"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FT04"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="404" mass="47213" checksum="6C177265E7B38EEF" modified="2009-02-10" version="1" fragment="single">HRAAEPSYLSADAPIQNYRGFLNLGVIILIVSNFRLILGTIRSNGFVLTTAVKHYKNLNHLKEDPWQEFPFVSGFLLQLVFVSIAFGIEWMLCRKYFNENFGMILHHFNAHSALLIPLGIVWNLIDRPAVGAILLLHATITWMKLISYMLANEDYRLSSHSDEANINYPQNVTLRNIFYFWCAPTLTYQIAFPKSPRVRYWKIADILMRMTVSIALFTFLLAQIVQPALEELVSDLDETNGSYTAAIFAELKLSIANTYLWLLMFYTYFHLYLNLFAELLRFGDRVFYKDWWNSSEVSAYWRLWNMPVHYWLIRHVYFPCVRLKMPKVAATFVVFFLSAVMHEVLVSVPFHIIRPWSFIGMMMQIPLVAFTKYLYRKFPGGSFGNVLFWMTFCVIGQPMAILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTB8</accession>
    <name>B7FTB8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_33032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178127.1">
        <property type="nucleotide sequence ID" value="XM_002178091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTB8"/>
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    <dbReference type="GeneID" id="7197267"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33032"/>
    <dbReference type="HOGENOM" id="CLU_1356994_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTB8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="202" mass="22595" checksum="6D05B2422EF87E81" modified="2009-02-10" version="1">MDDELIDTAIELDAPQDPVWGSRPPSPPPADSIARDTSCQGILALTLYRALQSTLETVNDRTVEETNECGKNQPNSHVSPIFGDEATDRIMGAFGRAVAESQHFHHQQKHSQINLDGAPLPPSALLRGRLVSYNRHGTKWRLVVEHASLRPRHHRPKTLPKRERISLWNLPWPTIEGKEPENAVDTVSIPGMLEILAYNDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
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    <name>B7FTD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Phaeodactylaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178135.1">
        <property type="nucleotide sequence ID" value="XM_002178099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTD4"/>
    <dbReference type="PaxDb" id="2850-Phatr43760"/>
    <dbReference type="GeneID" id="7197039"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43760"/>
    <dbReference type="eggNOG" id="ENOG502SVSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781827_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTD4"/>
    <dbReference type="OrthoDB" id="38376at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="2">
        <location>
            <begin position="109"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="34513" checksum="D400C40911447667" modified="2009-02-10" version="1">MSTQKAFDPFDLSASQEDWDTSRSGSVNITPRNASSTNAHDVNSNPSMDSNDSFDPFGIATLSQTPNAGIRSASDDPPTRRPREDSPSTPPEVNRVTRQSVPVTALPPKLVLKLTMYEEVSSQARIEADGTLSSNAAIEGSVYAQVQCSDGRKNAPFALATVDPDFSVRPNQKFLWNDATMNNNAFAVHIPKPELGYVPVAHYSLTKEVQHLPVLLERKVTVQDTSCRLAVQVRSKLTNSGDIEDLTIVVAVPERVNGDSIEISRGEGVWDELKRTIQWKLKALETGQSFMVSAHAKLWKPAQEDDDIRFPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTN2</accession>
    <name>B7FTN2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178447.1">
        <property type="nucleotide sequence ID" value="XM_002178411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTN2"/>
    <dbReference type="PaxDb" id="2850-Phatr44307"/>
    <dbReference type="GeneID" id="7197969"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44307"/>
    <dbReference type="eggNOG" id="ENOG502SI9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339045_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTN2"/>
    <dbReference type="OrthoDB" id="47765at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="788" mass="87858" checksum="F44E7A8B831E59E6" modified="2009-02-10" version="1">MGNSPSSGSSSRKKRNSSGQHDEDDVAALAQKVVSESVRDLQASVQSGLKKLEDHDHPAAQLIDSVCGSYLDKNEHDTSSGTISYGESDCEDTSMTDIQSLLKDSQGNSSSRRQQVLPTSSSCNYDSQAHPEHIKHPSSVPTPLASAFAKRCYFTKAGIAKTSQHYEGLTLTGDVVLMLAAAMKLKGCPTICDEDLRRVEQTFPTQFSRLPDELLLSSGWRRISKYCHFSNKPIPDGIPFFRGYYFLLAAAVGLVRPMDVEPLTRDTLVLLETDYPTTCDSAPPSLIQDPDQWTLVDKFCFFSGGPINTDENVYYEAELDGGYIYMLAFLSPSLTPSELYKLDQEAELGGLKSVAAVDEVDSVYDLTERDFADLQLYHLGPCRALPQYILQPLSWTKVLPPHFLSARQQALRKAQDYERAVGVQSAPIVHQPQMAQFMVGSSQARFTGQEGRSNNTTDVDRSMEINYPQEDPPFDVYESSLAQQTFSTRATCEISNVPVDEAMNAQGAVHIDTSQRPRNHRLDPPEDEPPSLRKDHAGLSYQYNEFIVEEDPSFDQSNDLYPEVRDQNYDGTDSDRKLSCGHHKQEQYAQNDKYYQQNGQGYAQVSHDRSSPLSRVESGALPFRSLESQNGAESSRSFHNTEEMLSTNRQIHLHQRGQMEFRVAAEQEPHASWDDVVPPERHGVSGGTWESEMSSAISESSSWTEDTDIQDRSLRRALILQMAKSRMKTTKTGKIGHTVPVLLRDIDGTPGGEHSSCQQVDKDDENKSERYSGDMDAGINIDFTEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTU4</accession>
    <name>B7FTU4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">PHATRDRAFT_10752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178208.1">
        <property type="nucleotide sequence ID" value="XM_002178172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTU4"/>
    <dbReference type="FunCoup" id="B7FTU4">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTU4"/>
    <dbReference type="PaxDb" id="2850-Phatr10752"/>
    <dbReference type="GeneID" id="7197834"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_10752"/>
    <dbReference type="eggNOG" id="KOG1784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_8_0_1"/>
    <dbReference type="InParanoid" id="B7FTU4"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="86" mass="9545" checksum="06BF56DB275E67D9" modified="2009-02-10" version="1" fragment="single">ESVCVVTSDGRIIVGILTGYDQVQNLILNDAHERVYSVDADVEEVPLGLYVVRGDNVCLVAEVDETKQLDSQRVPFPLPSIQQQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUA5</accession>
    <name>B7FUA5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002178525.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr44489"/>
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    <dbReference type="KEGG" id="pti:PHATRDRAFT_44489"/>
    <dbReference type="eggNOG" id="ENOG502RW8W">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_2019719_0_0_1"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="123" mass="14330" checksum="5DF6EDDE3D570901" modified="2009-02-10" version="1">MFSPRVSGVLRKSAQARSNVCRGPQVRRMAGSHYLKISKTHTMWGEAFGTVCWLWIFHRARHDLPVVLGFRHPWEHAEDPFSPHTHHHGEQPKPESRSDAWDKFTSKAMIQKEVDDDEDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUC3</accession>
    <name>B7FUC3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_11088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178570.1">
        <property type="nucleotide sequence ID" value="XM_002178534.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B7FUC3">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUC3"/>
    <dbReference type="PaxDb" id="2850-Phatr11088"/>
    <dbReference type="GeneID" id="7197725"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11088"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="InParanoid" id="B7FUC3"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="201"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="822"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122766" checksum="F03F52EE57AC1FC6" modified="2009-02-10" version="1">MTIETESGAVSGTRGTAKRDTLRANEVAVQKIWDEEKVFETEPDDRESFMVTFPYPYSNGHLHIGHAFSLTKAIFRAQFERHRGKNVLFPFAFHCTGMPIQAAANKLTSEIELYGCPPQFPEADPEVRAKMEAEIAASKEAKAAQPENKSKGSKTKLVQKTGTGIVRQWNILLKMVPEDEIPAFQDPLHWLSYFPPIGVDHLHNFGAGVDWRRAFITTYVNPYYDAFIRWQFEVLKEKGKILFGKRNNVFSLVDGQVCADHDRSEGEGVGPQEYVLIKLKVLQPGHGQSRHAKMEAILAKYDQPVYFVPATLRPETMYGQTNCFVLPDGEYGAYMIDATNEIFIMSARSARGLSCQSYQGNEYFTKEFGKILCLETFTGSELLGLPLKAPMAKYDKIYTLPLLTISMGKGTGVVTSVPSDAPDDFVSLKALQDKPDFRAKYGITDDMVMPYEVVPIITIEGYGDASAVFMCEKLKITSFNDKAKLQQAKDETYLKGFNMGIMKVGSHSGKKVSDAKPIIKQELILAGQACLYFEPESRVVSRTSDECVVASTDQWYLAYGEESWTKAVKKHVLNSDNFNAYDPAALHKYDYTIGWLQEWACTRQFGLGTFLPWDRAWVIESLSDSTIYMSFYTIAHFLQGEGNLTGDKSKSPCSIDPADLSNDVFDFIFRKGPLPSDSNIPAKTLEKMRTEFRYWYPMNLRVSAKDLIQNHLTMALFNHAAVWEEEPELWPKGYYCNGHVLVDAEKMSKSKGNFLMMNDTIQTYGADATRFACADAGDSLDDANFSRETADAAILSLITEDAWISETLTSVDLRSGEENLIDKILLNETNRLIASAGSNFARMQFKEGLKEGWFEMLNARNDYRAWCKDSGVPMHKGVVLRWAETIVILICPICPHWSERIWKQIGNIGLAIRAPWPVAEEEDKILTRQAKFLRDSIKHFRSQAGRAKKGWMRASILVNDSYPQWKIDTLVWMQGQYDVSSGFSPGFMKDLKDYTAKFVKDKKLIKFTMQFASFMKKETEDVGDAALDVLLPFDQKEILQVSIEYIKAQLNIEELDIIQLGVEEAPEVPERVRENVTPGKPSLYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUY4</accession>
    <name>B7FUY4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_34177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178400.1">
        <property type="nucleotide sequence ID" value="XM_002178364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUY4"/>
    <dbReference type="PaxDb" id="2850-Phatr34177"/>
    <dbReference type="GeneID" id="7197897"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34177"/>
    <dbReference type="eggNOG" id="ENOG502QZ3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2089527_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUY4"/>
    <dbReference type="OMA" id="GDYVCKD"/>
    <dbReference type="OrthoDB" id="408899at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48136">
        <property type="entry name" value="RUBREDOXIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48136:SF1">
        <property type="entry name" value="RUBREDOXIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855362" description="Rubredoxin-like domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="6">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="117" mass="12525" checksum="CEF221715A72DEEE" modified="2009-02-10" version="1">MAKAVVASGRRVSILLILLSLLSLIRGFVPITIPSTAAVRSGPSSTQLYFFGQPKDDGSPGDYLCPDCGYVFTKGPKAWAALPDSYSCPPCGAPKRRFKKIPKGSSSGKVEVKKSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVP2</accession>
    <name>B7FVP2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178965.1">
        <property type="nucleotide sequence ID" value="XM_002178929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVP2"/>
    <dbReference type="PaxDb" id="2850-Phatr44798"/>
    <dbReference type="GeneID" id="7199753"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44798"/>
    <dbReference type="eggNOG" id="ENOG502S4FA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049110_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVP2"/>
    <dbReference type="OMA" id="RIAFIFR"/>
    <dbReference type="OrthoDB" id="192440at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="460" mass="51240" checksum="48CDDE348E1423A6" modified="2009-02-10" version="1">MPFLVAVGAAYVAYKRNELEKAARLDPDVTVAGKVACSLLDVERELSVFELPIVTVTFFEGSYTNIVKSLKARVETILSLNPWLGGLLILDRDDQYRLKLYYDPTGSDRPPGYFHVYEPFIIPLCRGGTPETPYEDYGKLMAALDAVVQPNEQLIGKNKPLWKVSIIPDSVAPNDRFALVVSMSHICGDAFTYYKLLNMLDEDAKLESLNPIRPENFQKVVEETFGKLEANYLRDAIRRPLVNFHENTDDPVVYKIFFVDEEWLLDTKARRKSAFDAASLATVVSKNSVLSSWFYKLNGASIGLLLVNLRGRLDGCAVGNCDAGNYIHAIPYTAKDYVSASLIQHSLARLTRHDVGKASPLPQFGWNMTSSVSVSWEQFFRKEISLGEGATMSLHLPVYNLESLKVLPDRVSLISTFTACPSGTNGARRRLGALVLCRKSVASKIGRSRAVEELIAEAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVQ6</accession>
    <name>B7FVQ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178747.1">
        <property type="nucleotide sequence ID" value="XM_002178711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr11144"/>
    <dbReference type="GeneID" id="7199761"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11144"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323257_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVQ6"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="127" mass="15058" checksum="0C247DF70DF229D0" modified="2009-02-10" version="1" fragment="single">MDLDAVEVGHDTRTSLMVRNIPNKYTQQMLLTEFMDNGHGPGVIDFFYLPIDFKNRCNRGYAFINFVDFKDILPFHRRYFGKHWRTFNSDKICDITYARIQGKGAMLKRFENSALMEKDDEYKPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVX8</accession>
    <name>B7FVX8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179007.1">
        <property type="nucleotide sequence ID" value="XM_002178971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVX8"/>
    <dbReference type="FunCoup" id="B7FVX8">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="MEROPS" id="M17.A01"/>
    <dbReference type="PaxDb" id="2850-Phatr44868"/>
    <dbReference type="GeneID" id="7199576"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44868"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314376_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVX8"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855514" description="Cytosol aminopeptidase domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="545" mass="59248" checksum="4247D34E83FD36AD" modified="2009-02-10" version="1">MLYPALTVFGVSLFLLANAVADASFGSWTNSAPNLRMEWTPIPVNVHVDAISDSNTTLDTYDLLFLGMNQVGKENSTIAGSLQLARINAKYDGAIDRLLEEATNFTIGDKTAIMTYNTASGQKPQTLIIIHVGATAADARKVGTDLARTIQGGKKAKSCAILLPNQKSTREASAYVTEMTTALWVGLYKDKRFKSIKDDTDDAGNVNTIDLIVPDGNYDRETIRNAIANGRTHSAAVYLSKDIVNAPHNVLNSVSLVDTAQRLNKMYKRTLRCQILDQEECQRRGMGAYLGVARGSETPAQFIHITYRPPKSTYWSKSAPKLRRLGIIGKGLLFDTGGYNIKTSMMELMKFDCGGAAAVLGAVRAIAELEPRGVEVHFVIAACENMINERAMVPGDILTASNGKTIEVVNTDAEGRLTMADALVYVDQELDCDEILELSTLTGACMISLGTSIAGLWTNNDQLAVRLLESSARTGEKIWRMPMEADYRDALKSKVADLKNLGARYGGAIHAALFLQEFVEGDKPFAHVDMGALRGAPMGLSLYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW55</accession>
    <name>B7FW55_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M23ase beta-sheet core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179044.1">
        <property type="nucleotide sequence ID" value="XM_002179008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW55"/>
    <dbReference type="PaxDb" id="2850-Phatr44932"/>
    <dbReference type="GeneID" id="7199616"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44932"/>
    <dbReference type="eggNOG" id="ENOG502S43W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_913559_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW55"/>
    <dbReference type="OrthoDB" id="41845at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12797">
        <property type="entry name" value="M23_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050570">
        <property type="entry name" value="Cell_wall_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="M23ase_b-sheet_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21666:SF270">
        <property type="entry name" value="MUREIN HYDROLASE ACTIVATOR ENVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21666">
        <property type="entry name" value="PEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="Duplicated hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M23ase beta-sheet core" evidence="1">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="30963" checksum="DF64F1958F8740E0" modified="2009-02-10" version="1">MGFVAESAFRTCVVLVVFKLSGREALSESVENSEGKSFLQGHKIPSETLSSFGSYPNPLNLTDSDRARFHPVISFPTIHTQDGTVVPNIQILDFTSASAHRQLATPQEQRLRREGGSSPTDQLVRKDYAVGRYDENRVGLYESALFDDLENHIDGYAGRRTLHMGIDLDGPLLTPVHAFCDGTVLNVGFNAALGDYGNVIVVEHNLPSQNMDLSTERRRVYALYGHLDDAAIVDKKTGDKIVKGQVLGRMGDIHQNGGWFIPHKRTTCPELSRWLTGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWZ5</accession>
    <name>B7FWZ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_7621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179248.1">
        <property type="nucleotide sequence ID" value="XM_002179212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWZ5"/>
    <dbReference type="PaxDb" id="2850-Phatr7621"/>
    <dbReference type="GeneID" id="7200117"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7621"/>
    <dbReference type="eggNOG" id="ENOG502T9JH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328040_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWZ5"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866:SF2">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8649" checksum="7A21192BF72E24F1" modified="2009-02-10" version="1" fragment="single">GQHLLVDIENVDASFLNSAHQLAFAMVDVIEMSGLTLLSYHCHGLEPIGVSCVGVLLESHVSFHTWPIEGVITLDLFTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA5</accession>
    <name>B7FYA5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002179667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA5"/>
    <dbReference type="PaxDb" id="2850-Phatr45617"/>
    <dbReference type="GeneID" id="7200390"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45617"/>
    <dbReference type="eggNOG" id="ENOG502SW3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2175978_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYA5"/>
    <dbReference type="OrthoDB" id="196545at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852764" evidence="2">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="105" mass="11592" checksum="BB0D8E72044F4CD2" modified="2009-02-10" version="1">MMSFFFTNVLVLLVLCLGISVNGFVPKSVLAPQTFAARRSSTTQVYNFFGEQERDSLTRDSEPEQFFSTNTDKMSDEEKLPIAIAGVAFITIPFIAGLIALYAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZD1</accession>
    <name>B7FZD1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_12459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180129.1">
        <property type="nucleotide sequence ID" value="XM_002180093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZD1"/>
    <dbReference type="STRING" id="556484.B7FZD1"/>
    <dbReference type="PaxDb" id="2850-Phatr12459"/>
    <dbReference type="GeneID" id="7201042"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12459"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZD1"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053264">
        <property type="entry name" value="Lipoate-ligase_2_inactive"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506">
        <property type="entry name" value="BIOTIN/LIPOATE A/B PROTEIN LIGASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506:SF1">
        <property type="entry name" value="BPL_LPL CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="20384" checksum="59FBCF749263B284" modified="2009-02-10" version="1" fragment="single">IVLGIGGKPRELLDVELVKAEGCVTIKRFSGGGTVVLDPDSIWTTVIGRNKHMPHVEAYPRPIMEWTATDVSPHSPSPIFALRENDYVLGERKMGGNAQAIVKGGWLHHTSFLWDYQPENMAYLTLPNKRPDYRGDRPHHEFLVKLHESYPHVQKIDFFRALSETCQNKFDIHNATLQE</sequence>
</entry>
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    <accession>B7FZH0</accession>
    <name>B7FZH0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_46003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180349.1">
        <property type="nucleotide sequence ID" value="XM_002180313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZH0"/>
    <dbReference type="PaxDb" id="2850-Phatr46003"/>
    <dbReference type="GeneID" id="7200863"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46003"/>
    <dbReference type="HOGENOM" id="CLU_995585_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZH0"/>
    <dbReference type="OrthoDB" id="55211at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="31057" checksum="39D837A37DC67F43" modified="2009-02-10" version="1">MTEVAAARNNNLVAESDLDAALHAVDRHLHNHGRVGKGTLDETTRLALQASLHAHIQRIVQPVTDEAFHLYVHRNTLAVDQDTTTTVTGTTDTTCSTATGTTIDTTTRTIPRHDPYGFAESELLDVEALERVQALRTQVRDEAARIHALQISVLERAAQLASRQTQLQHCVPLAVSNHAFADTNQDERVDKIRVMQQALTTMQQALQQTQQALPTHHTSLQTTITAIELDMDKQNRHGLSQTELAITQREKDTDMDSAAVHPQALLDLPPMTRLANFLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZJ7</accession>
    <name>B7FZJ7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179959.1">
        <property type="nucleotide sequence ID" value="XM_002179923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZJ7"/>
    <dbReference type="PaxDb" id="2850-Phatr35488"/>
    <dbReference type="GeneID" id="7200875"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35488"/>
    <dbReference type="HOGENOM" id="CLU_843249_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZJ7"/>
    <dbReference type="OrthoDB" id="10592279at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="330" mass="36490" checksum="CB658FE4566716E2" modified="2009-02-10" version="1">MYRSHTASGRIEQKEKFVKLRKPFATDCRFLKHHNNFDVFCCEWVSAIRQLTAHSIPALNGRVATELLQGDTPDISEYAQFDWYEPVWFIDPTSAFPEMKKRLGWWVGVASDVGQAMTFWILPESCIPIARSSVACVFPEVAATDEFKADLAEVDLAIKTKIGNSKTVEENQVIEGQLANLVSGPTDDVFKGILLAKCALHAQKLQIPLAINGMHKNLDLYQKTLPSSVLEQEETKLQPIKVMVDFSQVCQCSDGLGMWVIETIQELELDTDKFSWLSASIGKLFVAAVNSITNILIICGGNEASDAELAPVLQYELAATNSDASDATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZV0</accession>
    <name>B7FZV0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_46041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180370.1">
        <property type="nucleotide sequence ID" value="XM_002180334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZV0"/>
    <dbReference type="PaxDb" id="2850-Phatr46041"/>
    <dbReference type="GeneID" id="7201408"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46041"/>
    <dbReference type="eggNOG" id="ENOG502QPVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429299_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZV0"/>
    <dbReference type="OrthoDB" id="43871at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34957">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34957:SF1">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="3">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="4">
        <location>
            <begin position="245"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69565" checksum="A82C56BD9B2096A1" modified="2009-02-10" version="1">MKQSTAILPHCSVVLVLLLSTVNIFGTVVVAWNSAMVAYRYNANQCHHQLSGLPSLTRLPLTPLRAASANCAAPTMGAVGSQTALRMLRSSNDDDGSDNDDFAENEGESPLSPVPQNRHNTRHLPEESEILGDEEDASPSSQTLESLQRNITATVDQKIRVAQAQAEIDRILKGPDAPFDTETELKKVKSIAPPVAESLLAQELDEKASQMEQDLYQAVKQQDYGKAATLKQEISQAHIDDCGAVLQVNAAFYRAFSEKNLGAMEALWLHDGTSTCIHPSHKPLVGSKAVLHSWKRMFRSSDGSFQRNWMEPHDIRLTVKGASTAIVTCDEHVYARRFVRGQKRQTELINKLTATNIFRKVNGRWMLTYHHASWHADSEAAKNALRGGGAGGATLRSGNSKARKSARSSRSNQEDDNDDDASIGMDGILGMNDFGPLLGSSHDKKGEGDKKPVKRIVMGSLSDIFNGNLGDILGNDESNDGNGDDANNESGAIIRFSRIDEDDDDEDDDDDDDEEEDEEGSETVSIIKKWGDSTETEGSGSSNKGSNGEGSEPKDALRQNCITALRKLCDQGSISPKQKRVLLTDIITCSAKGEFSMVEVAYELLCGEGEDKEVAEEEFADQCRVFAHSLPESPVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G012</accession>
    <name>B7G012_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180395.1">
        <property type="nucleotide sequence ID" value="XM_002180359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G012"/>
    <dbReference type="STRING" id="556484.B7G012"/>
    <dbReference type="PaxDb" id="2850-Phatr35973"/>
    <dbReference type="GeneID" id="7201332"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35973"/>
    <dbReference type="eggNOG" id="ENOG502SCFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_2_1"/>
    <dbReference type="InParanoid" id="B7G012"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="34223" checksum="FD240EAD55DE042A" modified="2009-02-10" version="1">MTVTRQLTKTAARVFGQLEGGGNPVTIFTSSVSLQPATRVALAQSCAWESVVVDRTRRSMAFYLPTGEPVDFCAHAAMGGVTQLLAPSAGSDASQSVSFTTDHADDTTRYTAHLHDHNIVALDLRTVYEEAPVPHPPTVRRILREAFGLRAGDLTQPPPRQSADAKPPYPTLRNASVARPKTLVYVNSLETLHAVKVPPVTNHHFRVACDAIGSTGVYLYAFDAADDTWACRQFPRASGYPEDPATGVAAAALAVALHKAGHVRDAYKCTQGTAMGQGSVLLVEDIQRRNADNHVSLRILGRVETDESEVMEIEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G059</accession>
    <name>B7G059_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_46131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180421.1">
        <property type="nucleotide sequence ID" value="XM_002180385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G059"/>
    <dbReference type="STRING" id="556484.B7G059"/>
    <dbReference type="PaxDb" id="2850-Phatr46131"/>
    <dbReference type="GeneID" id="7201231"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46131"/>
    <dbReference type="eggNOG" id="ENOG502QSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508541_0_0_1"/>
    <dbReference type="InParanoid" id="B7G059"/>
    <dbReference type="OMA" id="RCSLNQG"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056858">
        <property type="entry name" value="VSR_TRX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25011">
        <property type="entry name" value="VSR_TRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855668" description="PA domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="11">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting receptor thioredoxin-like" evidence="12">
        <location>
            <begin position="206"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56678" checksum="6F7F0A6CBD51EE0E" modified="2009-02-10" version="1">MTMTFLLQLLAFLGLSRHILAETNSSTSKVYVHIPFHLHNPSGFAHVQAEFGFQHTSGSIAEYVYYLDDHLCSPLAFNKTEGYPSHNQGLNPPFILLANAGTCSAVTKARHAQQVGASALIIADLHCNCDDKDCTKAFPKSECQEKDPKLVNDGSGNDISIPSFLMFKGITSQVKEKLVQNQPVLMELVWGLPKDATKDASLALWYHLWTTAYDPLVDVLTYHNVRAVSKALKGHAKFTPRYSIIDGTRFKCVNGPQENGPCDHLCTNKGRYCTTHATNLSGHAIVKETLRRLCIWEHFAKENEDPWWEYVLYHKEHCSEPHYFANETCLTKALVHANVDSHTVEECMKDAGDTEADVANTLLDEMIQKQKQSSVVALPAITVNQDVLDHMSSWSLFESICRRYWDSKVSTPEICVKCGACPNIIGCIEEGHCVGFHDKSDNENNAPTDKKENKRKKAYHGWRFFWFIVISCLCGLGYYQYKQQHGYGDRSGPFQGYLQLSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G062</accession>
    <name>B7G062_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_46132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180622.1">
        <property type="nucleotide sequence ID" value="XM_002180586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G062"/>
    <dbReference type="STRING" id="556484.B7G062"/>
    <dbReference type="PaxDb" id="2850-Phatr46132"/>
    <dbReference type="GeneID" id="7201355"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46132"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="B7G062"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109419" checksum="3CBBE2B94E7F9DB1" modified="2009-02-10" version="1">MATVSPPPSGQVLQLVSALSNPENHNVHVQSIRARDEALSASAESYGNLCYQLALVLVGSDNAAEMTAHINPSELDSWRQADPSTVLRLQQDMSMWIPFGQMAGLVLKNALLRPPILQGRQSLSIQPPSSDLLKEALLQALGCQHSELRAVASSVIATSAVSADSVQPGLCVRAWPQLIPALIANLQKTENAALMEGSLATIRKMMEDGPTELTQEELDSLIPVLIRFLSCNSEFCKVAALQSLTACLSDNVMPSALVLYFNDYLGGLSALSTDPSASIRKWVCRSIVTLLQLRTEYIQPHLQAVSQFMLTSTADRHHDAVALEACEFWFTFATLDEDVCTPAMVETIGGVLPKLIPILLENMVYLPEQQIELQARNEIDQQEGYNGMSTIKPVFHRSRAKHVGGPDESSDDDDGYDQDDEDDGEFDDDNNEWTLRKCAAASLDSLSSLFGADSILPSLLPALQNGLSSSCPWVQEASILALGAVAEGCRDALNVHMSQMHLYLVNHLAAPESPSTLPQVKCIAAWTIGRFASWAVEQVQTGAQGHLLAHMTEVFLTRLSDRNRRVQISCCSAFGVIIESAGDLMTPYLSHIYYGLVSALSRYQGRSLLMIFDVVGIIADCCGPSIAEGDLPSIYVPPLLQMWSGLAKNDPTDRTLLPLMESLASVAMTSGMNYQPYSLESFDNAMGIIEAVQLILTASGEKLEHEEEADPIVCATDLLDGLVEGLGESFPSLVSSSRRYGQHFLPVLLALCKHDIPGVRMSAIALVGDLARSSPALLEQALPELLKELVANMDPVQPSVSTNAVWALGEICVRCERNSSPLEAVVPDLVQNLIALLMGNGIERNGRGSDIPGIAENAAACAGRLAKVNPQFLAPDLPRFLLGWCDGMAKIVDPKERRDAFQGFVAAIYANPQAFQTSSATVSDAIASIIFAIVTWHMPAEIPEQSVVLLNGDYKFRPFPANEPELGEALFKLISDLKTSVDETTWRAVQQGLPVNIRRLLREFYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0B2</accession>
    <name>B7G0B2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHATRDRAFT_20547</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180649.1">
        <property type="nucleotide sequence ID" value="XM_002180613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0B2"/>
    <dbReference type="STRING" id="556484.B7G0B2"/>
    <dbReference type="PaxDb" id="2850-Phatr20547"/>
    <dbReference type="GeneID" id="7201155"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20547"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="InParanoid" id="B7G0B2"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="19" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="360"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="555" mass="59845" checksum="27E6223E69B2EF1C" modified="2009-02-10" version="1" fragment="single">LTQTKVQGASQAMLYATGITEEDLDKPQVGICSVWYEGNPCNMHLLDLSEKVKKGVEDASCVGYRFNTVGVSDGISMGTSGMRYSLQSRDLIADSMETTMGGQWYDGLIALPGCDKNMPGCIMAMGRLNRPGIMVYGGTIRAGKQPSTGNSLDIVSAFQSYGEYVYDKITEEERKEILQHACPGQGACGGMYTANTMATAIEALGMSLPYSSSSPADSKEKADECYRSGEAMYRLLELDLKPRDIMTKAAFENAMRMVMVTGGSTNAVLHLIAMSRSVQNPEVAITLEDFQRISNQTPFLADLKPSGKYVMEDVQNIGGTPGLIKFMIDNGLFDGSQMTVSGKTHAENLKDHPGLTPGQDIIRPLSDPVKKTGHLMMMYGNLCPGGGVAKITGKEGETFTGTARVYDNEQLMMRGLENKEIKAGDVVIIRYEGPKGGPGLPEMLTPTSAIMGAGLGDKVALLTDGRFSGGSHGFCIGHITPEAQVGGPIALVKNGDPIRIDARAEQRTIDLLISDEEWEKRRTEWTPPPLRATQGTLFKYIQCVATASEGCVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0W8</accession>
    <name>B7G0W8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_46346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180745.1">
        <property type="nucleotide sequence ID" value="XM_002180709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0W8"/>
    <dbReference type="PaxDb" id="2850-Phatr46346"/>
    <dbReference type="GeneID" id="7201616"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46346"/>
    <dbReference type="eggNOG" id="ENOG502S529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386118_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0W8"/>
    <dbReference type="OMA" id="CECCHRC"/>
    <dbReference type="OrthoDB" id="41648at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF8">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="716" mass="80777" checksum="362B4B6FA55D63D3" modified="2009-02-10" version="1">MSQDNLYEKSQSHYERKVARQRQLEMMEAAASGTAAEMELDTSSFAEADGSFMRQRNQETARRFLHDEDDSQEQTTPMRGNSTTGHHTLFGQRQSSGPSLNLMDHSAGVYTEQVSGLFSDAVHSVGKFIFKVSGSEIRGNEHDAIAATDGDVFLGDDYKRRSSMRATQCSTILASRVMFFKSLLRDKKRLGLLAMVFLSLFAIVYATNMALQRRPTEKILRENNSFRFNAVLDHIVTESVSHTEVFLNYDSAEYHALRWVAYSDPARLDPMDPLILQRYALAVFYYGSYLAFSEQYGEQKPIQFEGQQFEGVPNPGWTRKDYWMTGKGVCKWYGVLCEGEMVNGVEIADFDKNAPIIALNLTANQLHGTLPMEFKALDSLLVLDFSRNSIGGTIPLQLGRSMIELQYLFLNRNEITGTLPSEMGFMESVRSIRLGNNRLQGSIPSTFNRMYQLRDLGLDNNYITADIPDLEGCQHLIGLYLNNNRLNGRLDTSIGKLTNLFELRVDQNYLQGTIPPEVSNMRRLEHFRANNNLLTGTIPNEIFLKTLRMKEVDLQRNNFEGPLPVSLGGLSHLRLLKLNNNAFQGGIPQAWNRMHGLQILHLMRNKLTGTIPTGIAGLRELRDLSVANNRLAGTIPREIAACEVLTEAYFDYNQFTGTIPAEFGFLKHLETLRVSGNLFHGDVPVQVCALTREHVLTNFMADCKSKVTCECCHRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G178</accession>
    <name>B7G178_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180987.1">
        <property type="nucleotide sequence ID" value="XM_002180951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G178"/>
    <dbReference type="STRING" id="556484.B7G178"/>
    <dbReference type="PaxDb" id="2850-Phatr36390"/>
    <dbReference type="GeneID" id="7201541"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36390"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1144460_0_0_1"/>
    <dbReference type="InParanoid" id="B7G178"/>
    <dbReference type="OMA" id="NEESHYN"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="243" mass="27583" checksum="8059E52AD2C18AA2" modified="2009-02-10" version="1">MPTLYHIPKTISSPIVQCLLELDVVGNGVDVYETNFQEIKTETFLLRNPMGTSPTLEDDNIVLWESGAVLDYLLERYDTENRLAPRCLSAESLPEHSALRAKYLHVKQYIIATVYPFVASLFLHTQRSIEEQDEAYIQSTKRKWTSVMAPVLSQWLGEGTYFLGDQMTAVDFLVCKPLNNANSLGMLVVFPRLKSLLDRMKCRPTFRLAYEALPPNEESHYNRSILVVPGMTTCQVSVEDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1J3</accession>
    <name>B7G1J3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180869.1">
        <property type="nucleotide sequence ID" value="XM_002180833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1J3"/>
    <dbReference type="PaxDb" id="2850-Phatr46531"/>
    <dbReference type="GeneID" id="7201680"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46531"/>
    <dbReference type="eggNOG" id="ENOG502SU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069475_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1J3"/>
    <dbReference type="OMA" id="AHANIYH"/>
    <dbReference type="OrthoDB" id="39247at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855610" evidence="1">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="31655" checksum="10FD80AEE243E0CE" modified="2009-02-10" version="1">MRSLCYLWLLVLWLLPVVQGEGDPEIDFMLLGVSGTLQDGFELRHRLNYRHPQTQMDYPAQFVGTALVPGYKAYLDVKDKGFREYREANPPTVPNAVVMPTGCAAHANIYHVFFVPTPVLLNVLAGEPRFLSITPDTGLVDLQADETSDTVRRVARSVIKAQHKRDDSRVAIPLVTGVWFHDTFVESPPVYVRDGTKVTSFDGGLAVWAGVEREDLVDADATAWANVHTKIRQSERQAPKGIRPGTCRQIRFGVSDEQARLNFPFTSAQVEALLAPNDSEHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1R0</accession>
    <name>B7G1R0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_3832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181077.1">
        <property type="nucleotide sequence ID" value="XM_002181041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1R0"/>
    <dbReference type="STRING" id="556484.B7G1R0"/>
    <dbReference type="PaxDb" id="2850-Phatr3832"/>
    <dbReference type="GeneID" id="7201718"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3832"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G1R0"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="142"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="349" mass="39351" checksum="4C6929D13A27D170" modified="2009-02-10" version="1" fragment="single">GSYVEDQDHWWMAGIHRSVEIIRRKPKADIIDYQIQADASGHLDVHVECRPKSGQEVSRSIVLRLYDDEQTSDDGNIRYGSCLLETKPLSVDMYGSFNFATTLQNAKLWSAEIPNLYTLTITLSVEGQVGQVESARIGFRTVDISNGQVHVNGKAITICGMNRHEHDPDHGKVVSLDRMKQDIVTLKQNNFNAVRTSHYPTHSSFYRLCDYYGLYVCDESNLETHGMKPMGRLAHDWGWNSAFISRITRLIHRDRNHACIIFWSLGNEAGRGRNLSMARDLVRQLDSSRPICYESGGALAEGTGRTELTDVICTMYPVVPRTLELATRADEDRPVILCEYSHAMGNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G206</accession>
    <name>B7G206_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181127.1">
        <property type="nucleotide sequence ID" value="XM_002181091.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr46975"/>
    <dbReference type="GeneID" id="7202082"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46975"/>
    <dbReference type="eggNOG" id="ENOG502SM1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248595_0_0_1"/>
    <dbReference type="InParanoid" id="B7G206"/>
    <dbReference type="OrthoDB" id="49045at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1567" mass="175303" checksum="47A7BC4CDA65847B" modified="2009-02-10" version="1">MSGAEPRRRVFLLFSVQQCSDREMPPTCKKSKTSSSIETEVWRDGVDNASRSRLRQELNLLHSEMEIAQYGRTVNGQFRKKMPRKQSIVRTKKRKDLEKREAKQQEILDVVDTSHKRLRGSKAAQDYKVIEGSIVFGTKTQVETQEEDGLSEVSKDAGDGEREHNFAEPNEGGECPDTYEKSDIEHPEEEVDSTHLAKVSPQKTSGSSEPRKRSLHRLKNFKSQRMAHKHGDALGAHARGQSKLAIEKLKQVAREAPSAPQVYSSLGMVYEDILKDSRRRHETVDRCLDDDNLSEHSPFFSSYLTEAGAELDSSCHRNSAFTDFSDALLNELVDIAKKAYGSYHIAAILCKRDYTLWVRAAEMALEIAHLHSSVLVLQGVSESAQTFHQSESERWLSEAKRDFETADNLHPPGIDVPAKLATVLIELGCLSEALTLLTDLKNRKSKADACSEFESSYQAWLLYANLMLQIGHECIQWEKGVQTNRNYMFRRWLRKFASTFNWRERRLQALCKALEAAAGSTSSAHLLTWLQKRAEDLPFATTHDDESPTSTEMVEIDVQSIMRGRERGIEEGDDSYHLTSSKIEQDLLLRRNEAELADFDKTTRDMIVDNASIAVKRRASIRKELIYRHQQQIADLSTLDLGSRLRETSVADALNERGGVACGFMSSHSIGASCTTVCQISSILMRHMIFLHLFEGAVLVGDTVALYMKERAARHERRSEFLRIRTAKRLSISNRVVQDEAYDEMHDIESDDEDILLSDEDHLTNETGIFLSLKSGALPPELLVLKSLAYVGIGGKDYLAAKGLESVNALVQEPDSWFTKDTRRVKNCGTCWESFRQDMTEPLRKTTALSLTAKVVGEVGKMREMANFLRPLFDEYETVLFAQGFVDQLIETLQSMPCSKSTCHTFDVIVAASRFRLQIAAKIISSGRDKSKSTALIILSLEKSLSILSKMWSIERDRSIPEPCVTLLAVVAEAARLVAKLQMGSDITQSSLENIYTHILRAVSHICDHDGLDLTLDCKDDVLELLSEAPFAVSWMSSSHEVIALRSYNMCVAKNVSFFSGWEKGEFAEQLLRYREVPNLFGVTTADSRTSGFVGLSLEIELEQVWHVMHSIVPETSAFDFRNQLMAVRKTQWYEETKGDIEAAEMRFSIASFGEDSGLSLLLSFAKICLERAKLSRSELEKNKNVLNALSIILPISQFCLNTKVWESAIGSAAAGANGERVALEFKRIRKFGMGGTVRPSGRESASTKKRALEPQGSETRFRGWFEGENNKYPMRNFLNIPCSSFRDAWHSCSGDETVVSIETKTAMQRLARSVGLLRNCYTEQAIERASLSIATLLLDLAAKPGCRNPFICMQQATLFSSQAAKGGTSDQPFKVSLPNQLAVQPAQALAILGRADCLQAIHFCDEAAYLCWFVVSLCRQRRDHRRDDFGWTRQWKIIAVYAYNKSSESGFTWSSESVKELQQARADGIAWSATLCGDGSVQKNKNTEEDEGEIDVESFSPAIKVDRSTGFTEVGDVLADAPVLNNSNPSVGLQCSSSEESPMKPGPFLPDAAGNYLESSPGKLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G347</accession>
    <name>B7G347_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181725.1">
        <property type="nucleotide sequence ID" value="XM_002181689.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47370"/>
    <dbReference type="GeneID" id="7202419"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47370"/>
    <dbReference type="eggNOG" id="ENOG502RRC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253942_0_0_1"/>
    <dbReference type="InParanoid" id="B7G347"/>
    <dbReference type="OrthoDB" id="44198at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2245"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1891"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2256"/>
            <end position="2271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2341" mass="260341" checksum="4DC3BE93419AC086" modified="2009-02-10" version="1">MVWEGANVRQSVESVEDTNAVTAAGAGNKRYTKETVEAALSRLHTSYATAMECLGAWHRADQALRRGDSIAQTEQRPGSQAGTLRDVGQTTRQLFESALLRNPLVAQHAPAFHDYYSKDYVWEAPPTLTSAGHRETVRRVAYLSLVNYADLLLSGCACPIPRLPPRTGQKEHLLDKGITQPLATFREEKHCCWNRPRNDTETSPVGDSDTEDPVETTRRALTVLLDATALDPTDPLVWLKLSCLARRLGRLKTAVAMKDDTLLLPYRRLERHGLEMARIALPPNVPPNRLVLRALVELEEEETIFFTNGYDSGPLLQDVMEIRLSIPRYSWSILGRMLMRVCREGNLYTVTATAPHTNSHRHRGLSGPLRSAPLVRLELSPLLAVPSMVLAGICQFLTPAELARLEMTCRGLSYAVIAARAVHDHEQDLRASRQGNLNPAKLAPLGSGQPKPVVAETASDNRSTEVILEVDPNGDAATTDVNRKSRKKDHQTEEKRENQRVSKRVRSQMITSGKRAERSSRRSSLEYCVVAATMDCAPGDSKYDQLRREKIDWDHLLDLPPTPSALSAYWARSLADPTPLRTISLDVFPRDRQARERISSSSLTSFVNEWGGLDKPERRAVTPLGLLFGFVAHASLHRNGWTCGAFDVLDRILTPCWSTCNRNAPGRLNSMNVFAVDLLHVELRLKRCERDDSGDTELDGDASFLSRSVPVLVSLVDDLDEIYSGPSFAKLWVVLKVRCLWLAAAFYMWRGRIALCVFESREAEKEGLTFVAKLLDLMVKAQVGAVLTPHLESPTRSGLHWRELSVSSLRTYQNEIQASSVVLLAQEKFSQALCNIADEGDAVIDPISIDSLVAIGNLILDRYRVPVGSSEDKYSELITDFISSTGAMLVSSQFSVHPGTVQQDSIGSECDDLLPARNPAARQLKNMTNPSILAILNTSSIRNSKKALVLELAQSRYDASKDGESLSEDSSLFSDISTDKNEEGEFGKQLLLRQYATTATLLLHRIRELFVLRLTEQQKVQFSNSEEFRDTLASSFDICRSYASTAIWFNELSEETPADLNVLLSTIALLTAVQNAGLVLVPEELERNYFIGLASILEQQRSTIASLMDCELSRQERVAHQKVASHRARVAGSVSFHIGQIFAAHLCTPSSRQLVASSFFDELSIPSLVIASTIDSLLWFRDLSVKDDHQSRAAASLRNFCFSLDRASRETLLVPTALAIVGTIGALASTKDGKLLPAKKECLRNTDLAEFFDSDDSAVDWLSDDSVVADKVGHEELLRSISQSVHAISLVFQSLSAETMLTYKDTKEYATEHGPLLPLLAARVLNMYADRLLTEFLEDPEKGTSTLSSDFPFGTRSVGVLLDSVLYKVYKCLHGFSFINMRDGKECSGPTIIDSKQRTFLPEDAKATAALYSCMMRSYGQGRKSPPKSALELLTRALPSAMESDLSRTVRRFVFSTANGRIGANDIVSIINQDGERRADFKCFENWHWEKLHEMEDIKEEKDELLAVRRGVSHFLAQGPLPTYQDGAPNVRAASAKAEEALSRKFNAILDDLCHGSIADCKGWYKAAQCLLVRSDLIADRLGLSKGFVRSDHFNVPEWKGFVYDTLAIEELLKRQSEEASIHTKHWVEFLGPDLSIFLHYNWSSFESLRALATEMEASLSHFVETDDVDTLKAREAWDEIEHLFRTKDFVAWQEAWGGLFVSSLRQLAARCMALGLYILNQSLGHGDLENKVVLSELTESLGMSLYAELMGSQLYGYPMQEMPQGQKRCIATAALACFSHSVHLSRSVNLDKPADVPRATWDILFMIGKCNEKIASTYRAERFSFSAIDLLNKQGTRLYEQHMNNAFESYSISLSEAREIEREGGLIFEQNGGSAHGSTEVLYRLHASRLKCLIAAVDRREDERASAEEEALRLTEKYWFSAPQLDSRRSDARERIWAVLADTVSALAQCRSEHSFFHRSVYRHAQALMWAPVLNDPINERPNGSFGAVPGTKAVKVRGLNSATNAADSGAVVMSTLFDKKRSQLCAVWVANGSASSFQSINNSVRKYDCLRGKYISAYLECLKLSKRRSDLETFLRWTASCHRDLPSYFAASAFAQGSSPVKSHTQDSLIVRTRSLSSYHFLTSTKRLANTALANVILQEISGPSDRKDPETQLKAAYGCFLRLNSDPDAFIKCKWWKYHRSPSGMRPIADALMHAYKKIAKSQSPSTNQSDWGEGQTSETLRLSLRKCKELFPSATGSFLSSKASMNKSKRKVDREANGSGTKRKEPDGTFTALRSFVVPVPKGLSSADTFLTSIIIGSTTKKLRLTVPEGEPATLRFSLRVPVSDEPDCGADASSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3L8</accession>
    <name>B7G3L8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_14084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181813.1">
        <property type="nucleotide sequence ID" value="XM_002181777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3L8"/>
    <dbReference type="STRING" id="556484.B7G3L8"/>
    <dbReference type="PaxDb" id="2850-Phatr14084"/>
    <dbReference type="GeneID" id="7202284"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14084"/>
    <dbReference type="eggNOG" id="KOG2894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037985_1_0_1"/>
    <dbReference type="InParanoid" id="B7G3L8"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="192" mass="22676" checksum="FEA0C04FA7A06BCE" modified="2009-02-10" version="1" fragment="single">KNPSVNTAFLPDKARDEQAQTERQRLEKEWKTRQEQTKKEKLEITYSYWDGSGHRRVVECRKGDTIGDFLERVRVDLCREFRELTSIAADALVYVKEDLIIPQDLTFYDLILTKARGKSGPLFHFDVHDDVRIGAIDARVEKDESHPGKVVERRWYERNKHIFPASRWELYDPSKEYGNYTIGDKRSRNNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3V4</accession>
    <name>B7G3V4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_14002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181503.1">
        <property type="nucleotide sequence ID" value="XM_002181467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3V4"/>
    <dbReference type="STRING" id="556484.B7G3V4"/>
    <dbReference type="PaxDb" id="2850-Phatr14002"/>
    <dbReference type="GeneID" id="7202369"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14002"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3V4"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="398" mass="45042" checksum="F7C614D8C65F7B40" modified="2009-02-10" version="1" fragment="single">VILGQPVLFDFSGVTGKMHVVVIVLGDLGRSPRMQYHALSLLQAGHFVSLIGYEGEDLIPALYEFSNEQLGIIRFKVPSPRLLQKVMPVYFVWRIFSLTVWSLFALLSVHAKRKYPIDCILVQNPPALPLLSVAYTFCWILRLLQGKRACLIIDWHNIGYSMLKPGGFQILARTYERIMAPLADGHFTVTKAMKNFLHATMNIPDDANIRVLYDCPPDMFQPISFEQQYDILYELDKKFCEAYCRPRKGRPALITSSTSWTADEDFGILLAALILLDDRIKSEKSSLKVMVAVTGKGPQKAAYEEKISQLSLEFVAIQTLWLKPENYPKLIACADFGVSLHTSTSGLDLPMKILDLYGCEVPVCAADFECLPELVLDDRNGRVFRSHEELADQFWELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G403</accession>
    <name>B7G403_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CDS1</name>
        <name evidence="14" type="ORF">PHATRDRAFT_54756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="14"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181988.1">
        <property type="nucleotide sequence ID" value="XM_002181952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G403"/>
    <dbReference type="STRING" id="556484.B7G403"/>
    <dbReference type="PaxDb" id="2850-Phatr54756"/>
    <dbReference type="GeneID" id="7202773"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54756"/>
    <dbReference type="eggNOG" id="ENOG502SDA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734593_0_0_1"/>
    <dbReference type="InParanoid" id="B7G403"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382:SF1">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="42231" checksum="CE797A31EAE76BB8" modified="2009-02-10" version="1">MPSPLLLSPAKNMKKLWEDLPRRLLTIGVGVPALWTCWSYSTFTRCLFFQFIHVLMCIEWAMSLSRMKTRWTILFTATSLSLANIESDALFLTCLVPLVAVLTLFLLPQQTQQQYECHSQSETVKNSSTERIANNCLAKKNDDAGSERRKDVSITQSSTFGSSKGPDESAGLLQISILLGVLLLTVPNRTWLQLSQLDFTYTVNVLFSVWNGDTGALIAGRLSRMLRIQHHSVDRTRDSDVALPSISAQPEWLRKISPKKSMTGLYGGVLTTLLTYVYVMPFFWSRIGNRLQSTLASESSPAIFYPHEAPRLERYTVGALLGVAAILGDLCESCCKRYFGVKDTSKLLPGHGGILDRFDSSLLAVLFYHYYVVTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4A7</accession>
    <name>B7G4A7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181879.1">
        <property type="nucleotide sequence ID" value="XM_002181843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4A7"/>
    <dbReference type="PaxDb" id="2850-Phatr37877"/>
    <dbReference type="GeneID" id="7202822"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37877"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_938326_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4A7"/>
    <dbReference type="OMA" id="CSESHGD"/>
    <dbReference type="OrthoDB" id="44887at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="132"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="297" mass="33856" checksum="378BD91A952AC7C4" modified="2009-02-10" version="1">MIWSKGSPVQAMFQYGGKVRSQWRSVTDPQKCLNKAIRHLHSFSRLLNIPTAALPVGPSIQKEFSETIASSYFSQTPMIIRNYPVPTERWSDRAYLLDRVGSDLHCDVEMGHYNQAEKLNITFGMYLQYLQQCSESHGDTSNIPVDQLLYLAQNDLPQGLIPDISVPDLCKDSKIGLGEGHLYQTMLWMGPKGSISPLHFDPLHNFLIQVCGRKRVMLIDRNQSVETLYSGKMFGQQSNTSAVDLENPDYKQYPLFTEVSPVYKGEIGPGDVLFIPSKWWHHVRSLDFSISVNAWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4N2</accession>
    <name>B7G4N2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_14327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182105.1">
        <property type="nucleotide sequence ID" value="XM_002182069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4N2"/>
    <dbReference type="STRING" id="556484.B7G4N2"/>
    <dbReference type="PaxDb" id="2850-Phatr14327"/>
    <dbReference type="GeneID" id="7202900"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14327"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_845852_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4N2"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="22735" checksum="30D4B1B3A4C16D7F" modified="2009-02-10" version="1" fragment="single">IIVVLDMDECLIHSQFLSSTSAAYAHQLQQQRQNRHRNGSVETFQVSLPEGDLVHVHMRPGLPEFLARVTEKYETHIFTAAMPIYAKPVLKRLDPHQNLTAHWYRDSCTFHPTTNAYVKQLEVLPPLATNDLSRVVLVDNNPLSFLANPDNGILVSSFYDDPHDDTLEAVWKLLQELEDVPDVRPTLRSRFGLQKALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4P2</accession>
    <name>B7G4P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog subfamily C member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181947.1">
        <property type="nucleotide sequence ID" value="XM_002181911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4P2"/>
    <dbReference type="SMR" id="B7G4P2"/>
    <dbReference type="FunCoup" id="B7G4P2">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4P2"/>
    <dbReference type="PaxDb" id="2850-Phatr47726"/>
    <dbReference type="GeneID" id="7202905"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47726"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4P2"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65644" checksum="E5FC8DE92CEE746F" modified="2009-02-10" version="1">MSATTPPVASSKVDLFEYTEEQLLEEKVLTHYEILGISTFCSQDDVKKAFRRSSLKYHPDKHGHDKDYAFLALKQAHDTLYDHEKRQAYDSTTLPFDDAIPPPRDKLLQDDLLLYKDNDFYELYRPVFERNLRFDANLRPDAVGNAKNGNHNGKKKKAGKAKAPPTLGDADTPIAQVHAFYEYWIHFESWRDFSAQATDELQVENELENAESRFEKRWIQKEIDKRAKQLKKTEMSRIQLLVERAMEADPRLRKFRQEQLAAKEQAKRERQEKAEQQKIQAQLEHERQQQQEVVDRQRRAEEKVTREQQKKHIRKARQSLRKMASASFESLESEQKSSIVWADTYDMNLDVEVLCTNLDLTGLQSLAQELENITCPKESLTMIHQEVLVAKQRETDGDFSNGEQSSPSHNGTFSTKETTTSPVVTPALKPNLWTKEELSALAKAVKKYPPGGSSRWEQIALFVNNLCKQDEPRSKEECIEKYNNVAKTHSKPTESTNGVAAASEPENSSQSNEDVWTAEQDQQLQDGLAANPASMDKNERWTAITECVPGKSKKQCVQRFKVIRDALKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4S8</accession>
    <name>B7G4S8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182125.1">
        <property type="nucleotide sequence ID" value="XM_002182089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4S8"/>
    <dbReference type="PaxDb" id="2850-Phatr38045"/>
    <dbReference type="GeneID" id="7202739"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38045"/>
    <dbReference type="HOGENOM" id="CLU_845853_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4S8"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="187" mass="21345" checksum="C29ECD8EA6A878D0" modified="2009-02-10" version="1">MEVGRGENTRSQYLEYIDRGSVTPETFTSAPTLAPIAVTVESTNMVVVGFLIGLIILLSILFLIMSAPPIMRYIQRRREADPKRIELRYATIEKWLISKRVLAHSENCEIFSCTRSHETKGSNNHLKPMDSCDTVETDDESSCRVGRECPICMEEFLVDDVVSWSPCLQGTCSHVFHHRCIKVWEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Z5</accession>
    <name>B7G4Z5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182159.1">
        <property type="nucleotide sequence ID" value="XM_002182123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Z5"/>
    <dbReference type="STRING" id="556484.B7G4Z5"/>
    <dbReference type="PaxDb" id="2850-Phatr47806"/>
    <dbReference type="GeneID" id="7202958"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47806"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766098_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Z5"/>
    <dbReference type="OrthoDB" id="48924at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="362" mass="41655" checksum="AB7942729067CCFC" modified="2009-02-10" version="1">MTKACAPTVCIVGGGLSGIMLCRAFERRRQELLLERAEYGKKNDKPSTHLDNLPILTCFEKAAASDGVWLRKNSIRESFHKQQPQPKMNDDLRSTRLPLNIEFYDHPYDEYFGTAAPEYLPHSEMLLSVLAQGTARCADFWLRYFCFGMEVVSVVYNEQSQKFAVQIKNVQTNATIVRHFDKCIWACGETRAPNISTSLRRSFIDGDFADNIIDNKSNEARWVDKGLRDKRMLIVGEQITTEDLALEGLKIGVEQIYISIRCKPPSFFDTTARSTKKDQALWKQNMIEVTEKRKCICFTRVCRDWPQTCTQCEGIERKLRNVKNAIICTEDNLSKLDNPLRDHLPFWDNGQKVFSSDDWIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G506</accession>
    <name>B7G506_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182331.1">
        <property type="nucleotide sequence ID" value="XM_002182295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G506"/>
    <dbReference type="PaxDb" id="2850-Phatr47815"/>
    <dbReference type="GeneID" id="7202963"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47815"/>
    <dbReference type="eggNOG" id="ENOG502SMB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504797_0_0_1"/>
    <dbReference type="InParanoid" id="B7G506"/>
    <dbReference type="OMA" id="INQCWKF"/>
    <dbReference type="OrthoDB" id="43078at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852923" evidence="3">
        <location>
            <begin position="22"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="540" mass="60994" checksum="2870C2DEF0F1E8B5" modified="2009-02-10" version="1">MRLRRLWTFATTAVTAGMVTARRSRDDDHRMPHDADRRIFHNHTIAAQRERIRMRQERFRQHVHSMPPPIGIEPVTLADFAHMQGDRSLGWWGGGSTVTAGSSVAVSEDVLADPTQEYDKWAQAYRMLGGFIDCDHSKEEEGHHSQDQNQNQNKDTVACSRWMMWASYVNPNYQGYEYKEYFGDSPYSKLDCHASDTEWKLLGVYRQEFYQYIEQISKHLWAIDDYEYVVALAGLAYMTDAVCWQIGATSDGAAIYAGVAPKPYGKFQMALYTDEYCLTPDDSLGLTFDDFGLTSDIDLGSKDATDDDGKSWAYDWWYGAQEYTLTSLNEVYEEYKYCTSCVDYPTYQDGYFIGDDGTDDDDLINQCWKFYSHDSFTCEAECIAMAHAQGTILSINYGDTTFGKTSSSFYSRSGRSTSSDNNLAESPLARLLANVFLTLAFLLFVATFLAFAVARRSRYRESRSKKSRRLLSGSSRSGRSSSRKSRRSGDGIFRSSASPRRSSSRARSKPRSSSRRSSRRYEPPSSTLGADGGGAGDATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G583</accession>
    <name>B7G583_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182371.1">
        <property type="nucleotide sequence ID" value="XM_002182335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G583"/>
    <dbReference type="PaxDb" id="2850-Phatr47880"/>
    <dbReference type="GeneID" id="7203095"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47880"/>
    <dbReference type="HOGENOM" id="CLU_449384_0_0_1"/>
    <dbReference type="InParanoid" id="B7G583"/>
    <dbReference type="OrthoDB" id="49380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="66797" checksum="324AA9AF6AADF987" modified="2009-02-10" version="1">MPETTNPSKHRRRGPEKSFSAAEQRRLLNRRHDQAVQIRKSRTADARQRKRQSNNAVLSSTKQEHDIVPLTNAWLSFLQQPDLEHLIALQNQLAVDGQSATVFFRKALEDQSGATARRFVRSLTHILQSDPRSVNPAIGVLLEIQEVTLVPTTLRAADAYYGSPPLQWSDLMLEEDDLMQKLLLHFGDSSVPTILTTILQDCPRAVRTLRSSWPRLVEALPITASCCEALVRQDASTPASDFLQVLTTSHITNLLRHSDESVSFAGAALLECLTRREDVAVEAIMRDGALVLALGEKLHFSVTCGVKNVHGRSLLHVFLQILGNIAVACEGHYVPMLISLQHQTHSTVSLVASLQETMQQRLNVEVLSVVGSWLCDAGLPFHLSTTEGVSSFIPTLLDILTDTNLSYSGTPLMEWQREAACALQTALSPPPVGPQALQDPAIEVTLSMIVTRYLWPNDAERKRQITQALVDLLDKPDWDAVTASLQILDRLLRVVPQSRIVMEECGAVRKLEGILDRTTEDLLAVDLAADLLDIFIGSDESDTEDDGVGMNAVTPGLRNDAFVFGMPTNANVGAFAFGDVPSATSVSAGRGRGRTLPAWMNNEHCQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5P8</accession>
    <name>B7G5P8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_14412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182288.1">
        <property type="nucleotide sequence ID" value="XM_002182252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5P8"/>
    <dbReference type="STRING" id="556484.B7G5P8"/>
    <dbReference type="PaxDb" id="2850-Phatr14412"/>
    <dbReference type="GeneID" id="7203244"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14412"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_1"/>
    <dbReference type="InParanoid" id="B7G5P8"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSY HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="7">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="32294" checksum="1CDB796C2F96A116" modified="2009-02-10" version="1" fragment="single">LAKSRNRLLQNIEGLFTGVSPEQVLDDLQDILLQADLGTKTAEDIVAEVKSLREDSTKMLSKDDLKSIMRGKLIEALNTELSGAIQFSPLVDKTPTVLFVMGANGMGKTTTIGKLAHRLRNEGNQTVLLAACDTFRAGAVEQLQQWAERAQVDMVGPSTKVTTPSAVLYAALDKGIAEKYDTILVDTSGRLSNNDQLTAELKKMKKVIQKRLSRENDEEGKPLPNLQVPHETLLVLDAAQGRMALDSAKVWNEEIGLSGLILTKLDGSARGGSVVAISRDIQLPVKLIGVGEGIEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B7G606</accession>
    <name>B7G606_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P1B, P type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182641.1">
        <property type="nucleotide sequence ID" value="XM_002182605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G606"/>
    <dbReference type="STRING" id="556484.B7G606"/>
    <dbReference type="PaxDb" id="2850-Phatr676"/>
    <dbReference type="GeneID" id="7203272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_676"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_1"/>
    <dbReference type="InParanoid" id="B7G606"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051014">
        <property type="entry name" value="Cation_Transport_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085">
        <property type="entry name" value="CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085:SF5">
        <property type="entry name" value="CADMIUM_ZINC-TRANSPORTING ATPASE HMA4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC45928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="710" mass="76022" checksum="A8A106184326F13F" modified="2009-02-10" version="1" fragment="single">SVYFVQGICCASELPSVRKIVKPLNGVHSLQINVTTRRVYVEHDADVITAQTIAELIDDALDESIATQIALQDLESQSLHWNVLMSGVFWIVSMLSAVPGWSTLRYAGLVAMVFGLPPVIRKAWQTLRRWEFDANCMMVIAAFGAALLGEFDEAASVSFLFCISEWLEHRATHRAREALSTIVALRPEHANVIHPLTKQMLIVPADQVPVGALISVRTGDKIAADGVVVEGTSSVDESSLTGESIPVRKTINDVVSGGGINIGTTQLVVRTTSSVEDSAVSRLIRLVEEAQANRSPTEKMIDGFARAYTPVVVALATLMCTIPWLFGQEVGREWTLNGLIIIVVACPCALTISTPVTYAAGLAATAQRGIVVKGGASLEALGSVKKVVLDKTGTLTQGKFNVVHLENIGSIRSRKEMLQLLALMEAPSSHPLSATLVKAAKQEGVSVPTDMDAKEHTILKGEGVTANVNGKQVYVGNRKLFERLGMLSNVDQAFLGLTDAWSSSGGTVGFIGVEGEGIIGAFSMTDMIREDAADVVTALRASGHEVLMLTGDGEGAAKSVAEQINLPNSAVHYQLTPEDKLHFVASIKCPQPKHFQVLQRRPLVLFCGDGVNDAPALAVADIGVSMGEGAALAMEMSDVTLMDSSLSKLVYVMYMGRRVVRTIQENIALSLLCKLLVVTLTFAGYMTLLYAIASDVGVMLLVTLNGMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G656</accession>
    <name>B7G656_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182666.1">
        <property type="nucleotide sequence ID" value="XM_002182630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G656"/>
    <dbReference type="PaxDb" id="2850-Phatr48148"/>
    <dbReference type="GeneID" id="7203491"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48148"/>
    <dbReference type="HOGENOM" id="CLU_1520740_0_0_1"/>
    <dbReference type="InParanoid" id="B7G656"/>
    <dbReference type="OrthoDB" id="10660899at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="177" mass="19834" checksum="B43DF3B1418A0210" modified="2009-02-10" version="1">MTDVPVISALSFINDEWGQKYELYSPGRNYLYTGKVPQVGQLTETLVVDFMGNQFQLSGIVAEVNPIETWKASISNGIRELRDQASLYVQDTSATPCIVGFGLATIAAPSRDPTTATLKQGVGLQKGRIYRIEYKADDTRQNLYTVQRVTELPMEYVHMLPPIAIDFFLHNSALWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6I6</accession>
    <name>B7G6I6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182579.1">
        <property type="nucleotide sequence ID" value="XM_002182543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6I6"/>
    <dbReference type="STRING" id="556484.B7G6I6"/>
    <dbReference type="PaxDb" id="2850-Phatr48258"/>
    <dbReference type="GeneID" id="7203364"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48258"/>
    <dbReference type="HOGENOM" id="CLU_685999_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6I6"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43506" checksum="693A2A1A3C4B5743" modified="2009-02-10" version="1">MSSYRSLHRQEILPGTAIWDIATAPLLSSNHATSVANTAVSSATHWRFLTATSDGIVRLYSAAEASLDAKQDVLDASALSVTLTHVLLGPSQTYPVTGRVLGCTQVSVARNYVGDDDDAGNLVVASLELPGTVRIWELDERMDDRLPRTTPDLTDENDSPSQIRALHEFTVPNATGTTLRLCPPRLQGVGGDVVIAVGCLDGTVALVATGLWTPQRVDHAGKSKEPTKAGTVLDSWGSQGSAVPLCFTWHPVQPQTLAVGREDGIVDVLTDSRKSQHRFTQHENPVRGVAFTDDGHLLVAGSDDGFLTIWDFSRPVPALVHHVTMAHRSLILKATPLDHRRFLTTGADRQLHVWNVGQMSTGPVHTFQTDHSVWCTERVVRGASRLVTGSDTGWLQVYSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6W5</accession>
    <name>B7G6W5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182802.1">
        <property type="nucleotide sequence ID" value="XM_002182766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6W5"/>
    <dbReference type="PaxDb" id="2850-Phatr48368"/>
    <dbReference type="GeneID" id="7203636"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48368"/>
    <dbReference type="HOGENOM" id="CLU_1126367_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6W5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23001" checksum="58EF78C0C7758751" modified="2009-02-10" version="1">MSGSNPFQEEEDSNQRTTESRQPPPSRVSPSDVKLNISGADYVVNQAVFRKLQALPWRYEPITEAWNLHTSPYLFEILLQYVTFGVVPDASRLCSTDLEELVPMTMVLGWDDLQMHLEQRKKPLLSSKRRLLRRGGSGVKDWGDPSQTSQRPTPQTHSTSGESTNLFSNMAAAWWRGSAGRSRGQRRAGSANGRGLSQWSTHAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G763</accession>
    <name>B7G763_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182851.1">
        <property type="nucleotide sequence ID" value="XM_002182815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G763"/>
    <dbReference type="PaxDb" id="2850-Phatr48449"/>
    <dbReference type="GeneID" id="7203685"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48449"/>
    <dbReference type="eggNOG" id="ENOG502RVQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100299_0_0_1"/>
    <dbReference type="InParanoid" id="B7G763"/>
    <dbReference type="OMA" id="MTIRGDT"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47698">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47698:SF2">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16036">
        <property type="entry name" value="Chalcone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="253" mass="27599" checksum="4EC1D03BC16FDBDB" modified="2009-02-10" version="1">MFATAVSRLSSRFQILPRPIYRRTLATLVFGNNAHAEKSASTATWWVVAALGGLTLTSKTLLDIKIPRGGDVIAAGTPVQEKATGILFPQLCNGYYIAGCGVRVKYGFVKVYAVGSYFDPLAMSAVKKGSRESMEQALLDPTYPRTIRIVMNRGLSIEKYTSAIVEALEPRMKGQDLEKLEEFKQLNPAVDLVQGAELEMTIRGDTMLYKNAVGGVGTIRSRVFTEAMCDVFYGSDAVSPTMKQSVLEGIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7D1</accession>
    <name>B7G7D1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183125.1">
        <property type="nucleotide sequence ID" value="XM_002183089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7D1"/>
    <dbReference type="PaxDb" id="2850-Phatr48686"/>
    <dbReference type="GeneID" id="7194917"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48686"/>
    <dbReference type="eggNOG" id="ENOG502SYDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791005_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7D1"/>
    <dbReference type="OrthoDB" id="48064at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="38925" checksum="11E842559546F66C" modified="2009-02-10" version="1">MEQAWDAADVSVQKVEYLLRGYAFHIPGTQWNRWTPSDPQGKPDNALETMQSLVGRMLDEGHAYMTVRANRMEETHGIREDVEGASPRISLGESASNFGNLFEAGKSNDSESITEISGNNTPVNSANALAPKSEENENRKSYLDDFAFPGPTVVMYNALLDSMACLAKDGSVNPIQAKLCMENVLWRHTIDGGDAGNRNPSTRPSVLPFNAAIRVAAELRYDATRKDPENLLLRDEALLLAFGTFDAVTHSRVAESNSATYKYLLRAVAKYLPPSLSKGNIAYGMWTHARLQGLIDPTVIAAYATANEPSNGELFDAWARDTLYGKNVTDLPQKWRRNSFTRRFHGREATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7D5</accession>
    <name>B7G7D5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183127.1">
        <property type="nucleotide sequence ID" value="XM_002183091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7D5"/>
    <dbReference type="PaxDb" id="2850-Phatr48689"/>
    <dbReference type="GeneID" id="7194919"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48689"/>
    <dbReference type="eggNOG" id="ENOG502SAMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487901_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7D5"/>
    <dbReference type="OMA" id="SRFTYQR"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855519" description="Fe2OG dioxygenase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="241"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="559" mass="62941" checksum="E3617187DDCABC08" modified="2009-02-10" version="1">MSWPTVRNVQKLILLTIQVVSSFVPRPTARSRLQWTTRATASCRLLSSTEGPNRDDLPTPIYHHIDLYNENSYTDDVETVLGRVDGFMRLLEQQEAWPLLHESKIRDRIHSQHTRDCEAASLNLAPESPVLRDQQCSTRYEWIFSGTKSYPLAAQSLEPILNTTAISTIREAAEAHWENPAFCTSRFTYQRPGNYEAHVTDLGERVRSIVNETLTTRIYPLIRDVFWNDPTCSLAPVDQLCVYDALYIRYNSTQAKLLDHIGAGQPLHRDLGLISINIRLNNDFEGGGTFFENQLLDRKESDLEPGITPLTPLERGHVLLHKSSERHAGASTVDGVRDILVFFVSGVSCETGSGSGSTVPMPIQSAIAKQSRGYCDDCYSNNPLRAIFCRIAHQRYAVRVAPSDGEAWQYLGTAFMEYDTYLAVMKASAGLRGAVLQTATRCLQLATRLTPCDSRVWNNLALTLNRQWKLKSDASLLNTTEMAFATAHQLLKMSREKCDVEGELDNVNVNYGLFLSNQDRFMEAGCILEGTALKKIIDQDCGKAVEDAYELWKFCRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Y2</accession>
    <name>B7G7Y2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183097.1">
        <property type="nucleotide sequence ID" value="XM_002183061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Y2"/>
    <dbReference type="PaxDb" id="2850-Phatr39147"/>
    <dbReference type="GeneID" id="7194887"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39147"/>
    <dbReference type="eggNOG" id="ENOG502R15V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714693_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7Y2"/>
    <dbReference type="OMA" id="FCESTEL"/>
    <dbReference type="OrthoDB" id="41258at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="387" mass="44250" checksum="A7FE9EF32C513544" modified="2009-02-10" version="1">MSTPTRQRRKLRPLIITMGGPRRESLEALFAEPAMAANFEPPIFSPGVPSRSLRSRYQFLSQAYRAGLLPEAEWEAVRDHDCAPDEGDTSTDAFFAGLGDVPVTTGRRGSAADIRLHYSRELWQKAKGINRGRAVLGCTFAHLIALRVLVDQELDFVLEDNVRVPLTSCADRIWELLEATSNRKCHHRYYGWLGSVPNLRWIYDFHAPRFSHASDIFEHFAAFPFPSNEDIGNDLTAKEANSQSEINERDSETDHRQLDERKPGGNPVWGCYAYWISKEAFAELMETLRNDVGAMLWKTKRARHYIVKPIDKILPRLVMRTYGQEAVLLPSHPAFFRAPMLTSKIHTKWDAEFCKSTKFQLEHSGLSWSDLWLTAMEKAVVAYHEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G883</accession>
    <name>B7G883_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183426.1">
        <property type="nucleotide sequence ID" value="XM_002183390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G883"/>
    <dbReference type="PaxDb" id="2850-Phatr48744"/>
    <dbReference type="GeneID" id="7195029"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48744"/>
    <dbReference type="eggNOG" id="ENOG502SPKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553760_0_0_1"/>
    <dbReference type="InParanoid" id="B7G883"/>
    <dbReference type="OrthoDB" id="40970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="493" mass="55327" checksum="7CE47614CE5783E0" modified="2009-02-10" version="1">MRIKRRSTRRTCSTPRRLFAILLSTPLAVWFLAQLVGQGTVTTQTLDLTTLLAQTQTIQAISASDEPTQSFLAREKLEVSIVSNKHQADNYIDSSPVTLKSAAMDSPEDPSFTGETSSLARHEAAERTTSDAGIDLTDPTLYQSVDTQGDSSAATVMGVATGYDLSIFKRFVGSLRKTGYIGHIILGLAPDVDSEILEYLAYRNVTTKILQWTDCTYLDNSSTTKDIFKRTTCAAPYPDIKIRWSRFPLARDWLRECTSCTGPILVMDVRDSLFQVNPFGPGSPVVRGLQVFEEHKNRTTQHWLTKGPIFECKGVSYDETMLCSGTTIGTRAAMLKYLEIMYEEMKDWISHPRCRFNMNGDDQSIHNHLFYSGQLPFATANENRRGGIVNTAGFEGAQLVKQHSATMRARHGITHGDAMWKAFDGASGKRWIGAEFNICDDEGYFTEFDGSRSRVVHQWDRFGRPYINLWLNHQKWLVEDEIPSNRSSHLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G885</accession>
    <name>B7G885_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183299.1">
        <property type="nucleotide sequence ID" value="XM_002183263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G885"/>
    <dbReference type="PaxDb" id="2850-Phatr48745"/>
    <dbReference type="GeneID" id="7195030"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48745"/>
    <dbReference type="eggNOG" id="ENOG502S72C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784061_0_0_1"/>
    <dbReference type="InParanoid" id="B7G885"/>
    <dbReference type="OrthoDB" id="214at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="38499" checksum="40047F2411903BD2" modified="2009-02-10" version="1">MVWKCHIFAILYCGTVYFRKVTVYASRGGSWSNSSPQSSGIFNGRMSTPYHGDDDDNDVGIVGTGREFALFGGSQPLSTNQNSNSGPGSTIRNVSSRDLPFRPGSSSTSTPPRVNGLNSAPPSSFFSPSSNRRSRSYNGRGASFKRGSNRSSQSFFQPVADWWTASISPNVKNWPKIQCRVEPTTTLKIRKTFRPLKTVVQLGADFNTQLGVWQFRSSWEDAIIGGKLTLAGRELQLSKSWQLSVGAVEDLVTRLRFRAAVDLQTWKAYARVGFRTERLSPINVMEGFTLLKQLPLDGNHGHVKLEVKANFALPEPEIEYSTETQRSLIGMGDIEVNIEELNLVLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L5</accession>
    <name>B7G8L5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clp1 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_48855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183493.1">
        <property type="nucleotide sequence ID" value="XM_002183457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L5"/>
    <dbReference type="STRING" id="556484.B7G8L5"/>
    <dbReference type="PaxDb" id="2850-Phatr48855"/>
    <dbReference type="GeneID" id="7194941"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48855"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382038_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8L5"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="572"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="903" mass="99171" checksum="5F4DA46569EA89F7" modified="2009-02-10" version="1" fragment="single">MVRLVWSIEVLTTTFLAGNCVCFLLSIIPSVAAFAETLRVRRVLPSVSPQDAYARCLRGWKRDNLGLVGVPPPILLRDGHPDTGVGMLLLRIPPFGLKEGIVGCQRDECSTTMNYQVLNPGWFTWPVAEHEGWIRFASDGEQGCILEWTVQWTPLPLPLSFWNGFLKALTTVIVEAAASYVARGGSGAYQSVAIRKKDAWDNKKSFGLNRSVRVPTMMFSCATGGAFGAAFPLAEVDSSCTRRAGRACTGTLPGFCLVWADPSPPGVRRLMGRTGGLENSGSITLGAIEKIDPISMGKGVCPAAPDHGCTGHLVQGPSNEFGARFRHASHDFAIAMICAPSVGSFHSSSSEILRSLEQDKMRESSRKRPLRAEDGLQSSSSASDLDQQQQHHQDDVDTLGDATIAWYGSNEATVVLGATPLCLLGRGRIRLISGTVSLHGFCLTDEFRDFESPIYASWLTIVAEEHGKKGGEVAKVAVESTRRVAGVLVPTFEIKLATEPHSRPTVIPRRWTESLDSILQEQLCRQLENEKASQRKRPTAFTRLLEKESSSEKLAAKEMEQSAPGFKVVVVGAKNVGKSTCLRYAINRHLSMCSEVAVLDGDLGQPELSPPGMVTLTRLRQPIFSQPHLHLVTNEDNASAAAPRHEMAYWFGASTSQGDPEKYVSSLTKLVRYYHEKLLPQKPTLPLLINLDGWVKGLGMQILEAILLQIQPTHVIQILGDLNSKVFELSLPDEIHLHICHAYHVIPPEEQQRKTKMSTPTSDSESKETCALVDRQHDTGRVTSLSDIASLPTIPSSIPASALRTLRFVSYFLDDVSIWDRIRFGQKELIVDINCVIAKRFASQKPYIVPFEAIAVDFSSDEFRRDIWTPERILDSLNGSIVGLCCRTGKSDDEFDCCVGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G962</accession>
    <name>B7G962_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183713.1">
        <property type="nucleotide sequence ID" value="XM_002183677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G962"/>
    <dbReference type="STRING" id="556484.B7G962"/>
    <dbReference type="PaxDb" id="2850-Phatr49003"/>
    <dbReference type="GeneID" id="7195399"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49003"/>
    <dbReference type="eggNOG" id="ENOG502SFZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308265_0_0_1"/>
    <dbReference type="InParanoid" id="B7G962"/>
    <dbReference type="OrthoDB" id="427333at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855961" description="Cytochrome b5 heme-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="442" mass="49550" checksum="D9F09AE890083F3E" modified="2009-02-10" version="1">MSHLLSILVCLAAATVTCFTLPTFFKTESIVTSRSKPYQRDHHILFQTVKANSVSPSLDRFEQFANSTPDAGAPCVLTIEGSRYNLTAWAKSHPGGERILAKFNEKDATKSFRAAHHSMAAYEMLQDFAIDDSLQPPTYSLYSIPRWRAKLFTKEDRIGVHKYLGMFCLLNFIFRFYQMLLGDPSAGLGTRVGKGPSAFPVLFLVPHGMLSVSALIFPHIPRERVVGKPMIWQEYRIHNLIFGVRSVICTLFCALSFRYPTNLGVRRLSISGSCLSVLAANIGADLATKKLQPHETGSTTATMPYWEGCSVKTQKKFKQFYAYSQFLATLSCVAVINPAWPLSVLLAIQIASLLMTLVRKGLLSAKGYHMGYTASLIAPYFVGIRSMLYMKNLQFPIMLAFGYVLFQARRRGLNKYMLWVPVIVARIAIGDRLLDWSSWAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G974</accession>
    <name>B7G974_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183722.1">
        <property type="nucleotide sequence ID" value="XM_002183686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G974"/>
    <dbReference type="PaxDb" id="2850-Phatr49014"/>
    <dbReference type="GeneID" id="7195402"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49014"/>
    <dbReference type="HOGENOM" id="CLU_257150_0_0_1"/>
    <dbReference type="InParanoid" id="B7G974"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="391"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="714"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111618" checksum="BE8D7821CCE3D165" modified="2009-02-10" version="1">MATKSFDTEAQEDDGSTSECSPSQSTLLSLSGPPLFTSSSDNVPHKTKSAPIEDFSGYATPVLGQIRDDTASSNMPSPLYDEGYSEDMVLSDEELGEFLEDDDDDEETDEASNTLIRSVPVQRHSASELRMDRDFEEFVSHESDADDEGEDDEARNNSIIDKKLKDSCVHQSRTVIPKPPLHHRSGGSLVAVSSGDARGTRVNPSPVASAPNSPADRAYQYRRRSSSLGRPRRESMPSRHLLRYFRNLGSGGLGGSRNASFDYPSSEIGHTRSADADLEGDEELTSDENSYGANEFESSSDDSNAVGTGLFGRMQRPPVWSEMVALPQQFILTASSPNYLDPVLVARQKEISMAEADRFVSEHGLLLQAALQLMAERDQVGVEGSIDTADNIWKKGPLKKRTLGVGRRRSRPSSNWKVKYVELRRGNLCYYEDSGASGGRKIIHLRQTDTAVRKVSSKASGYVFEVSVQGYPSRVWMANSPEERQEWMKAIQAAVIGETDDLHRELDLTPHQKTLETYTSLRRKCESIDNHDTYVATVREAVNVNPVLRVPLVWVRDQLKESSSSRVEIEKASKLPKAPYRRLKTSIREFWISMSHISFAINGIAIAKQSSAASQRTLGALTRCILEVDKAFVTNDTTLGDERTLISELQAVSFARDILMSVLNSKERQDDLCSVHNLLNSDLVVHIPREEESVQIEISFAGEDLARDELPELSTEISGWLRTKGRKSGSKWRKRFAVLSGSVLSYYEAEFPRPHGLQGQYILENMTTVQEVESDDDQAFVLSVAIGDERRWLGFEEHDRCLEWKDAIQTAIDSCTPTDATVFAGPRSKSILKGAERVIKGAIPDGSLRGGIRVIKEATGGGIKVIRNAKDGGIKVIRGSIRGAVGMLRSSRYQGGNDANPEIRRRPSMHMLMNNAPTGKKEPTVQCLVQASRTFDVIKRCEASSQQGHVLFTVRVKLFQAFLLSGGSNGRIARGNALVELEFLGLGPADQTALCGRLGEDLESSRKQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G977</accession>
    <name>B7G977_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183724.1">
        <property type="nucleotide sequence ID" value="XM_002183688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G977"/>
    <dbReference type="STRING" id="556484.B7G977"/>
    <dbReference type="PaxDb" id="2850-Phatr49017"/>
    <dbReference type="GeneID" id="7195403"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49017"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008764_1_0_1"/>
    <dbReference type="InParanoid" id="B7G977"/>
    <dbReference type="OrthoDB" id="49057at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="541"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="869" mass="97480" checksum="48E2805CB3E921E5" modified="2009-02-10" version="1">MYSEEEILMDINVQCIVQAKSQSEQLNHLISFKSRIHTVFSEEQKRATVVVLLRRIVVVGEESEAAFFNCLVACGPILALQVAEEILRQIPSHAVPSALVVDSCLKVIHRFLLTEYHRESFLFDLQFYTSKKAEARVAYLDGFVSRIILLPGLMANACHTCRMDLPKWATPETYVRCIIEHACLYRFVDIPGTEVGKFYLQFLVNFVASRQGGGAIAAGLKCFYTRQLLHTHLDYSLIPRLKTMIATDVLCTMRPQECAELLFCIVQAEVREAYQAKLVLYQYSGVSDFLESMCVPILQSSKVVRDSFVRLTILQYQPPATAIVLDLNMVRSMLTMLLEPKTEEQRNKSETISSFAALLESVASAWSQSTFVDRLSIVRQQRISYFIWNALLLLPGPVDPLSNLTATLLDGVTLRLSCTTPQIRLSGMRVAVELAKKLGEELHFEELDNVGDISSELGVEMLNEAEEIFPKDGHAGEQSRLQIPKTLIDPDAEYFSDDSESGENVGKSHKEDDDSDWNDLDDHHFYSLDDSEDDLAGVTSPRYLTECLELLRTPESDSLAYHKHKTALLSLPDLVRSRPIDLVDVGESLARELLQMENKFSLDNFETSVSVSVVALLVMDPCSIGSAVVHEVFLDRAFANRQCALHVLSDAAYELSGYQAMENTIDKHRRAIIERTKQGRSLTGGDGIDGAPKTVARADRTRRWGGARRSDDSRAISNRFGRIAPVWFYRLLQGFCQLQNDASLWGGRIGSMLLTELFLTLANIVECCGVQPCGDVLAKDLFQLVWSFRNADVLEVRRVVLLCAAVSFCQVRQQNQPKLIADVTQGTLYTTLRDLELNDPDTECRDLAGFTLYKIKEAVQASLASDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9L7</accession>
    <name>B7G9L7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_39785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183796.1">
        <property type="nucleotide sequence ID" value="XM_002183760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9L7"/>
    <dbReference type="PaxDb" id="2850-Phatr39785"/>
    <dbReference type="GeneID" id="7195641"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39785"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870061_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9L7"/>
    <dbReference type="OMA" id="IHETETF"/>
    <dbReference type="OrthoDB" id="47321at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="320" mass="35212" checksum="464AC9520DD3E7C0" modified="2009-02-10" version="1">MGGKNNASRNVDYAIHESTFPVKLHYLLSETEDNGSDHIISWQPHGRAFLVHDHGAFVDHVLPNWFKQSKFPSFQRQLNLYGFKRFTAGRDKGAYYHEIFLRGRPHLAHRIPRVKVKGSGVRKPGAPESEPNLYLRPFLLTSDFNGDATAEEELHTVSKKPHTVIPDGPSSQSGPDVARIAGRALPVGSVAALYANAPPPRPPFPGRPSLHHFLAAQHWSGPPRGFGVPMHNPTMRRFDPTALSPHQLMSLQTALEEDNIRQREALLTSYATFPGRSSEPVAPSASTLQKLSKKFAATSASTAAQDVATLLQLAASLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9S8</accession>
    <name>B7G9S8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_55013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183942.1">
        <property type="nucleotide sequence ID" value="XM_002183906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9S8"/>
    <dbReference type="PaxDb" id="2850-Phatr55013"/>
    <dbReference type="GeneID" id="7195675"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55013"/>
    <dbReference type="eggNOG" id="ENOG502SPUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693494_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9S8"/>
    <dbReference type="OMA" id="WAMEAVH"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855600" evidence="2">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="398" mass="43101" checksum="95B4C641D3B403F9" modified="2009-02-10" version="1">MVSTGLAVVVHFSTLVLASAYSNNQATHHYRQDWRSTRLASVQHASSTVDTTSPVLPGVATFESWFQKLSGATCCTSVVHSTFGRGALRGLAWKSTTSPGTPVPIAKTLLATIPSSAVLKSDYNVDTWDADLACRLWHEVRKGSDSRVAGYVSLLTQGDNVPAISGSEVPASTALNAVRHWTVAQREHLQTCNAGQRVLDLSQSQEAKWKEKYSKLGDSSVDSSVPTWEQFRWCMEVVHSRAFCGVSTSGTVSLLPSIVAPLVASYAGYLYTSSQVNASYGVLALLATIAIAPTFVGILRPSSRAAVLLPLIDSANHFESADSTIDFNVLANAFELSIGPNCIKEEADGQQQLYISYGRKSDTELLLNYGFLPDVPCDNIDNDMLRRQMADAFVKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9W3</accession>
    <name>B7G9W3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183845.1">
        <property type="nucleotide sequence ID" value="XM_002183809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9W3"/>
    <dbReference type="PaxDb" id="2850-Phatr49224"/>
    <dbReference type="GeneID" id="7195527"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49224"/>
    <dbReference type="HOGENOM" id="CLU_1328611_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9W3"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="207" mass="22448" checksum="C648ACB17AE35DEF" modified="2009-02-10" version="1">MDMGMATAADSFCTSSMGGGMIMYMDGFRFSLKGGQPCLNLFFPEWTLDSKGKFVAAMVGVLLLAVAVEGVSKLRYCIIRAAKASYRSPDQNQWNLTLLRFGISSMHGAQALFGYIIMLATMTFSLELLSCVILGLGIGYGVFFQTDDVFRESGHVTTNPCCAFMEDEVKDLHSLKRDVVGAFHPDDTPVSTTVSDSGTDNCTPNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9X9</accession>
    <name>B7G9X9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183854.1">
        <property type="nucleotide sequence ID" value="XM_002183818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9X9"/>
    <dbReference type="PaxDb" id="2850-Phatr49236"/>
    <dbReference type="GeneID" id="7195534"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49236"/>
    <dbReference type="HOGENOM" id="CLU_704888_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9X9"/>
    <dbReference type="OrthoDB" id="48547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="396" mass="43985" checksum="1CEB0906585EF015" modified="2009-02-10" version="1">MHLSLQAINADDFAVLANKLKAELGQEKGNHIHGSIIPHENDILLGRGGKNNQHFGNIQLRNMTRQFCSAYYGATKKEKPAVARGLVQCIQNLNPPGRFLKHSLGGWEEATASVAQEKASQSLRDTVASVLKEANIQDGTHPKNEVFTQKCLDELHPGSSRHPKSATKDSVLFQDSTEQLPNKIARSYQESESSCQVRMPDSLAVNFGDQMLLSMDATSSISLQEEFNENGKRSRISFLEADLNSKIQRFSTDRAFCTMGLIDNSDFSSMANSKPQYQISSQVTTSRVPCTTSTKLSFDTWTGNGGFSLNDAARYAHLAAQRKRQFSTSINSESKEDQEIELFSADALDSIVWDDDDIKLDSTSSFQLAPGQHQAASAWDDEDAFRRRIRNLLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAA2</accession>
    <name>B7GAA2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184038.1">
        <property type="nucleotide sequence ID" value="XM_002184002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAA2"/>
    <dbReference type="PaxDb" id="2850-Phatr49343"/>
    <dbReference type="GeneID" id="7195600"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49343"/>
    <dbReference type="eggNOG" id="ENOG502SB8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047644_2_0_1"/>
    <dbReference type="InParanoid" id="B7GAA2"/>
    <dbReference type="OMA" id="QWHIVAM"/>
    <dbReference type="OrthoDB" id="45895at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23534:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23534">
        <property type="entry name" value="MFS PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="465" mass="49928" checksum="BAFB7A0EA872300A" modified="2009-02-10" version="1">MMTPREKPSLTPLPADGAYEESCGVVEELESCPRLLSGLERWNVFFCVFAWACTACNVTLVVGTGAVVMLSIGGTDSSTSLPLGAYFFGASIVSLTVTPWIFERWGRKIGFLVGITFGLIGTALGAASIVARSPPLLLVASVWFGMATGVGFFLRFAAVELVPTHFSSKAVTLVVSGGCVAAFAGPESAQATKDLFLNSQGQFEYLGVFFMTGVFNVANILCISLIHFRSSERSAGDDGAESEPLQRNRSEFVAMLRTRAFIVPVLFASTCWAAMSLPMSILRVTMGELGYSNRESLTVLELHFLSMYAPGFFSGALISKYGPSWACRLAVAVFAMAVLFMLVSESAETGSLATWILGMMLAGIAWNIGFSGATVWLLGVYRSSLRYKGWVQAANDTGMFAMSGVWIFSTSYISEAGGGGLDGWKTVNFVVVGFVGFASILLSSSILFQCRHLEYQHGDTKSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAC5</accession>
    <name>B7GAC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184172.1">
        <property type="nucleotide sequence ID" value="XM_002184136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAC5"/>
    <dbReference type="STRING" id="556484.B7GAC5"/>
    <dbReference type="PaxDb" id="2850-Phatr40052"/>
    <dbReference type="GeneID" id="7195762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40052"/>
    <dbReference type="eggNOG" id="ENOG502QQRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAC5"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10977">
        <property type="entry name" value="CE4_PuuE_SpCDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017625">
        <property type="entry name" value="PuuE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="84"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="42751" checksum="00B15215F266C8B4" modified="2009-02-10" version="1">MTTPSDYKCYHENDGLTKYGGRDLLGYGSHPPAPKWPKGTKVALNFVINYEEGGEKCLLHGDGESEKLLSEITGAAAFEGQRHKNMESLYDYGARVGFWRFHRLFTKKKVPTTVFAVGMALERNPAVCSALKETDWEVASHGYRWIDYQDVDEDTEREHIARSVRIHEKLLGKRPVGFYQGKVSKNFNLHIRGDHNVSSIFIVSPPQPNLNTRRLVHEEGGFKYDSDSYEDDLPYWTVDVDGMPRLIIPYSLAENDMKFTSPAGVATGKDFCQMLKETLKYLIEEGRAGQPKMMSVGLHCRLARPGRVAGLSDFIDFAKSYHRDVWICTREQIADFWYENHYPRGGGTPVKAEKDDTENTTNGAEQMATEDFEGDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAK5</accession>
    <name>B7GAK5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184093.1">
        <property type="nucleotide sequence ID" value="XM_002184057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAK5"/>
    <dbReference type="PaxDb" id="2850-Phatr40136"/>
    <dbReference type="GeneID" id="7195800"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40136"/>
    <dbReference type="eggNOG" id="ENOG502S1TJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAK5"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF4">
        <property type="entry name" value="DUF1995 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1995" evidence="1">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="213" mass="23292" checksum="BA3D56063D8D1842" modified="2009-02-10" version="1">MRPVQGKVVGFRTIPASYVARKQLDTTHCKSSSSSLDNVDDMSALLTSRLPTSVDDQVRQAAESLKRAARDGQRRHAIRLLLPVIGATELDDWPGGARQMMQAAKPLVQSILATAVSDKVVDFQEILLDESDGVYAILGQVTDDAKKDMCAVLLPSGDTVSMLQKLESQVGDKRDLLLVNPYGFFETTPVPGEYLFAKTRMGKLTGPNWANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAQ0</accession>
    <name>B7GAQ0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184233.1">
        <property type="nucleotide sequence ID" value="XM_002184197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAQ0"/>
    <dbReference type="PaxDb" id="2850-Phatr49472"/>
    <dbReference type="GeneID" id="7195942"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49472"/>
    <dbReference type="eggNOG" id="ENOG502SY5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417687_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAQ0"/>
    <dbReference type="OrthoDB" id="10676788at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="72627" checksum="4F8B51252AAED562" modified="2009-02-10" version="1">MEPQHRAPAPALHQVVALTLVYQRLAVVVAAAPAAFFVLPFVSRVFLGTLQWVTRGHAVFFLLLWLALYLAAYRLIHQLASSRIALEKTLRNNATRLPLLSGWTSFLLARYVWGPVATAMAIPETLPVLSFRAAWRTALSLALLGLSVLARYVGPKSIVRCSPFPLILNPLRLWFHHPFVHLDPKDHSQLQPDNRGRRLQSPTLAATVAQCTVALIVGVILAHINTTVLTRYTKPSLDNDPVVATAILTACIWTIAGPLVWTALDGVSHEFDPRPYQPQHHLNAQSINLMLRNLTKKLVLQSLLIPAVSIAFALAWWHPTRHTTHWFGLYATLGLSSALVALYLGALEEALRWSLFHPPADWTALVAQLADDSSMERQLGVLLYSVLQDTDIVAEVCRPTSRPGVTNLDTEESRRQERLVRDMSIFLSSKSNRATPEVPLEEDVLRLTILESLGGSERQPLNANASSARHNANVRAWVDWKLPKNANFTDGPPEPLIVPLVRALCVYIGGLGETLISRTQRARSEPNNTWILPPGMLTCADWALRALSRCLIFSLTGPDEKPLADWHSTHVAMLVPAAMQAIYLLRRGCQQFGHTTLVAACDDTASATIRCLTTTYRGRVDLVGLEPEPLAWVQSLVSAPSSRNSQALVVSVSHKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAS6</accession>
    <name>B7GAS6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_49491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184245.1">
        <property type="nucleotide sequence ID" value="XM_002184209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAS6"/>
    <dbReference type="PaxDb" id="2850-Phatr49491"/>
    <dbReference type="GeneID" id="7195720"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49491"/>
    <dbReference type="eggNOG" id="ENOG502QRYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051275_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAS6"/>
    <dbReference type="OMA" id="WTALHYM"/>
    <dbReference type="OrthoDB" id="45809at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="528" mass="58945" checksum="3A186C92493747BE" modified="2009-02-10" version="1">MSSNENAELPLRRKIWFAIFGCLQNSMVGGMLYGWACIDRSILSASTANGGAGLTLSQTTLMFSWASCAAMVSTLALGIVLDRYGPRLCSVLAHAIIALGCQVFAMSNRFETFALAVCLISLGGPGIQVSIVHLANLFPDNQYLVLSCLNGTISISFAVFAMFDWLWEKYPNVGFRSLFGYYALVVLVSLVASAIYWPDEPFEAPEKEYDPLEFLEPTPEEDYFEATTAHRHLLEQPLDSYLRADINPQLVRHNSYRASKKALDRGDEALISLKDQPFWRQFCSGTYFRTVLFFVTVCFLANFYVASFSTEMADSRNFSYESQRDLARIFTLIMAAGVLASLVVGVLMDRIGLDACTALTLLLGQGQILILVFVPDHRRWMIFGFVVYVFFRQFLFPVYIANLTAHLGFKYFGLLNGLGFAASGIAQVFMASLVQVVQGDCNMVSTDPGEDTQTVDCEIGRWMDLHVVEFVLMGLLLLAPWIESREKLRRQERIQELLRIASQTSMSYGSVSPSPSNLDDHARVGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAV4</accession>
    <name>B7GAV4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_40235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184145.1">
        <property type="nucleotide sequence ID" value="XM_002184109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAV4"/>
    <dbReference type="PaxDb" id="2850-Phatr40235"/>
    <dbReference type="GeneID" id="7195847"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40235"/>
    <dbReference type="eggNOG" id="ENOG502SRBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383807_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAV4"/>
    <dbReference type="OrthoDB" id="49098at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855972" evidence="3">
        <location>
            <begin position="20"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="621" mass="70352" checksum="4C1151B9C7393459" modified="2009-02-10" version="1">MRLVVVVFIATTNGLRVSAFAPVGTMGSVSVYRISRRNPRRARRAPAVGSIDVLFAAYDAEWQVGDVYRDLELLEQAINISNADVNLQYAQRIETLDYFAAQRRPLAADLAHSIGPSLGFSVTLWLWFYWSPFPRTCRRFVRTLNHALAAHFMCAAVLAPILALLVQQWRRHPEPLPTELQGIDPEYYRFTTTTWEDPKTSCRNFILCLLEQWTSVVLGFALCGPFLTSTTALPVRMITRTAIVASLRQYPQLWFEFSRSQQPLPLSGSVWLLRTLLAAAAVVYTPWFLAAEAALWMHAVHLPLARVALVYGTMAILAYATRYLPPSVKIRDVSTWNKVVSLRKYVLFAGVVAVFLPKVLPTLQRARSAAQWIGLPNVLRYQVRQISRTSVLAVAGMGLVLAAPCVHLAAVCRLVWIGYTHDFSLATDADQLQALLRDESDATQSRYQWRYRLRWRPPERIAATLNQWRKRFWYWFFFAGSVPDKLRREYGGKRQSEAHRQGLTVLQRVQEEQRKDPYAPKPDSTRWKSRAMERLAEKHQRDYDSGSFEDPLGVAVHQTLGIGLGFNFDHMGKPNAADVLSTRRLQARAAKSAIRRRPAPSGCGRRDPISGSATIRPDTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB65</accession>
    <name>B7GB65_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184410.1">
        <property type="nucleotide sequence ID" value="XM_002184374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB65"/>
    <dbReference type="STRING" id="556484.B7GB65"/>
    <dbReference type="PaxDb" id="2850-Phatr49602"/>
    <dbReference type="GeneID" id="7198252"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49602"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488766_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB65"/>
    <dbReference type="OrthoDB" id="44567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="59"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="558" mass="59366" checksum="CF535658E0A5FB72" modified="2009-02-10" version="1">MLIWLRSSSSTATVIAVLLVYRAAAVASALWSVSEYRLVDSSSAREPLTNDAKRVESRIIGGEEAIPGEFPWYASSSGSPGSGICGATLIHDDIILSAAHCSGQFDQGVLIGHHRFGEITEGAEFHTIDMEIRNADYDIHSQTSSHDAMLSRLTKPSQKETIGINSNEENPMTGDNLTVMGFGTTEFQGGRSTQLMRTTLLAVDFDTCNAQYANVELEPDVMMCTGFPGGGRDTCQGDSGGPVVTSDGTLVVGIVSFGVGCGLPDFSGVNTRVSGISRWIADQVCRLSLNPPADCPGIADEAPVLRIEIAYDMLPAETTFELKDEGGNVVYAGPEYGPEATDVWITELIGLPENQSYSFTIFDQFCDGFLTFQPVKASFVELYWLENAATKVLLARVDGNFGCNTTKTFILTNLLSAPTTVSPVATAVPSDMPSKVPSVTPVGNPSDQPSAVPTGAPRDVLSNLPSVRFGSNSGPSSVPSVVDMGFGSMAPTRQPSLVSEPTPVTPVDGDEESVRSSHSSGRRTKQWIQVCGKPWWFGAETLVGGMVLLWLGNFAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBD9</accession>
    <name>B7GBD9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184449.1">
        <property type="nucleotide sequence ID" value="XM_002184413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBD9"/>
    <dbReference type="PaxDb" id="2850-Phatr49668"/>
    <dbReference type="GeneID" id="7198307"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49668"/>
    <dbReference type="HOGENOM" id="CLU_517295_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBD9"/>
    <dbReference type="OrthoDB" id="38099at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="527" mass="58836" checksum="18CCC3540E771F66" modified="2009-02-10" version="1">MTDGSAVDWTTAVTVGAAALAACGVGVLTAASSDTVSRRILSPERTHAKRSAEYGYRWRQAMERAVLQCSYVLAGGVGNYNDEIELAQTKLVRDMAHVELLVQAIVDRKGRLRIGKICTDERMPSTDYYVWLYDQESSQIYQLPLTTFGMALADAMERKIHSTTFCFLADAAASTASALVKDLLQITKSAVEIYENPLWLTQLALLTRKNLHPRDDLERVLYAFCRMQAWNCEQPTLLISYGAAVTPILLPMLQQVFPDDRHLFCYTGCIQTAQAAFHGRRSFQRNHVPECVSDALQFPHPVSYTTPLSRSMLHSVNTMPPYSRALVSLPIEIADVVETWMAAVDAFFLLKEDERINGYLPYVLKTDYLLTPVSLDVRHWTTRSLLQYVCGSRTRGEVPSETLDAAFSYLRERKPLAPLAKIDAYRKPIENAVFQHKLILIENKTLQDTVQPTQHWTLKSTAKAGCACCLPEEDEEDEDLGALKGKLDMSRPGVFVLPGTLKKGKPSAAGKFVDGKMGFAFDPTKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBW2</accession>
    <name>B7GBW2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184518.1">
        <property type="nucleotide sequence ID" value="XM_002184482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBW2"/>
    <dbReference type="PaxDb" id="2850-Phatr49786"/>
    <dbReference type="GeneID" id="7198455"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49786"/>
    <dbReference type="HOGENOM" id="CLU_678758_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBW2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="43329" checksum="CAC0BF17EF66D190" modified="2009-02-10" version="1">MSRPRKTIEDGVKNAATTVQDGTVDETALPDHDDVDDITRWNVEDSDGCFDGFDPVETVWDKNDEDFGMPDSFSIETEHEQATEAPTISTQQGKPGISIFANRRSAPQKASAAPKSHTVAASANTPVSILGLNNPYSRLSYTKNAIEKDISPEDLEDPFAEDVAGQLPMKTPATSLGNQTKIDKHHHFDTSSAYTTLAMPFAKAHHSSQFRTPSVHEVRVNDARTDGPQSKNIHKRHEINTPTSAINRNTSNLVQRPMVSPDTGLDDNIHGGTHPSLTLEPASPPQAVTAADGTADSQEEKDDAVLINTVAQESDAVMETARENFDNVHKNFLESIRDFQDDEKKYTKAILDMNVLLDTSHAEMLATQVQVFDLIDRMEKIKAISRESSVVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBZ5</accession>
    <name>B7GBZ5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_5780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC44010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184611.1">
        <property type="nucleotide sequence ID" value="XM_002184575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBZ5"/>
    <dbReference type="STRING" id="556484.B7GBZ5"/>
    <dbReference type="GeneID" id="7198377"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5780"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_1"/>
    <dbReference type="InParanoid" id="B7GBZ5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="194" mass="20101" checksum="9F4A7B2ADBFE6E32" modified="2009-02-10" version="1" fragment="single">MATSLRLSGQRVLVTGAGRGIGRAIAQLCAAEGARVALTARTTLELEETARLLPKGQSLVLTADVTSDEQVESLVQAVVQAWGGIDILVNNAGGAQASKGLLHELPAVNLTRLLDLNVVSVHRVTAAVLKHAMLAQQSGKIINISSRAGKQGLPQMSSYVASKFALEGLTATLAAELKDQGITVNSISPGMVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC47</accession>
    <name>B7GC47_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic</fullName>
            <ecNumber evidence="9">1.3.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_30690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>protochlorophyllide a + NADP(+) = 3,8-divinyl protochlorophyllide a + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58632"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="EC" id="1.3.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.75" evidence="9"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184654.1">
        <property type="nucleotide sequence ID" value="XM_002184618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC47"/>
    <dbReference type="SMR" id="B7GC47"/>
    <dbReference type="STRING" id="556484.B7GC47"/>
    <dbReference type="PaxDb" id="2850-Phatr30690"/>
    <dbReference type="GeneID" id="7198587"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30690"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043999_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC47"/>
    <dbReference type="OMA" id="ASFIVDC"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033728">
        <property type="term" value="F:3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05243">
        <property type="entry name" value="SDR_a5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044201">
        <property type="entry name" value="DVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47378">
        <property type="entry name" value="DIVINYL CHLOROPHYLLIDE A 8-VINYL-REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47378:SF1">
        <property type="entry name" value="DIVINYL CHLOROPHYLLIDE A 8-VINYL-REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853105" description="Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic" evidence="12">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="13">
        <location>
            <begin position="50"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="391" mass="43369" checksum="F3824E2DB15002A6" modified="2009-02-10" version="1">MSVRRFRGLLGVCLVASVAAWAPRPRPRPVSSVLTAHTDASPLGTAIIAGATGYIGKSTVRESLRQGYDTFALVRDATKIDAKTKAEYMDGAHIIECDVCDEAQLQTVFREIADRTPDRKVQAVVSCLASRSGVKKDAYRIDYQATLNCLNAGRAVGARHFVLLSAFCVKNPWLQFQQAKLKFEAALQEQSDMTWTIVRPTAFFKSVSGQLEVVQGGAPFVMFGDGQVTRCNPIAEAELAQYLMDSVTDPTRRNLVRNLGGPDEPLTMRKQGEMMFRAVDKEPNYFYAPLWIFDVIINGLQFLADVTRSEQLEDAAETGRIGKYYAVEDMLTTDPEEKYGTVTLQEHYNRIAVEGQEYDPYTTMFARARVGKFGPEETAAEITTTEPVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCN2</accession>
    <name>B7GCN2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184906.1">
        <property type="nucleotide sequence ID" value="XM_002184870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCN2"/>
    <dbReference type="PaxDb" id="2850-Phatr40877"/>
    <dbReference type="GeneID" id="7198720"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40877"/>
    <dbReference type="eggNOG" id="ENOG502T2RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1550533_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCN2"/>
    <dbReference type="OrthoDB" id="46028at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="173" mass="18919" checksum="B4180369198FC29E" modified="2009-02-10" version="1">MPAKRRNYAATIFLTATALLIGDTVALTSGRALSRSASDRYAHRGIPCQSSSALLLKDGSRDSADKNSPQRQQEMLMEELSKIGAEKIAGLGVVERAKRAMLAEAIEDRIFHLTEEIEVLLEKNGTLAAQNRDRAIELAQQTKGLQVQYHELVSGQPSSVLQSLEALDSNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCV8</accession>
    <name>B7GCV8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_55138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184948.1">
        <property type="nucleotide sequence ID" value="XM_002184912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCV8"/>
    <dbReference type="PaxDb" id="2850-Phatr55138"/>
    <dbReference type="GeneID" id="7198762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55138"/>
    <dbReference type="eggNOG" id="ENOG502SZGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558363_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCV8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856099" evidence="3">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="489" mass="52503" checksum="7F89580B2CE178D5" modified="2009-02-10" version="1">MMKPFNNLVAFVVLSTLGNATAFEQLSFSSPAASQLSGSEIIIRDLADFDWEITPLDGYPIIAFNTTEGNDELVFRYNYTGDLVEGEKQLTARLLLPDCINDGDNSVVRSPPSALSNNEYEVGVDIVKDTISGSSFYSSLNDTAASISFCLRVDYELVAGNDQESVNFHETVVTVTVDLTADFRLSAIDITREGAANATETASLDYPVNAYFCNDGDVQVPGQLLSQGSALQFCVKIDDSVLDAVFVEDILEATISQPNANGRVGASASNIITGTVADSLTEKACRELGICNVKSQLLSKFFADADPLDLEVTGTALLSFGSASMMPSSSPVADTRRRLRVPITATINSKELKAIIDAQAGEATGSHFARSNNVASLGRGLQDDSAQSEFGLIVGLVNEDAGPSDTIENDGGIDVIVIVGIVLVISLLSGCCLFFFCFMKKRKDKEEKVDEKTVIQYDMEENKRDDQKHLSSNRGSTGASRGTPYRPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDZ6</accession>
    <name>B7GDZ6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185295.1">
        <property type="nucleotide sequence ID" value="XM_002185259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDZ6"/>
    <dbReference type="STRING" id="556484.B7GDZ6"/>
    <dbReference type="PaxDb" id="2850-Phatr41348"/>
    <dbReference type="GeneID" id="7199207"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41348"/>
    <dbReference type="eggNOG" id="ENOG502S80R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_922765_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDZ6"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="302" mass="34174" checksum="103195B11E58D527" modified="2009-02-10" version="1">MPTVAPVRSRRFVSLPLCLNILTFHTSPLHTVSAMKVVDFVRKPFIQRACAEPHTIPSVVSFFFGLDCHDPAQVQAQLRDGGALTTMKDLWFAGGSEYDQLCATHFADTIRAAGNGQLARNDPAWTQQVDGVVAQLVLCDQLARNAFRGTPEAYAYDQPALRLARTLHTDYRASRVASASRTIQGEYHPPYVAFLVTAFMHSEVLTDHEAVTEILQHERETTPEHLHDWWRYQETFEQEHRDVVERFGRYPHRNALHQRQSTPEEEAWLDDTENLPGWALSQLQDRPECAEDDVAVGTNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE51</accession>
    <name>B7GE51_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">UDP-Glucose-Pyrophosphorylase/Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UGP/PGM</name>
        <name evidence="14" type="ORF">PHATRDRAFT_50444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185375.1">
        <property type="nucleotide sequence ID" value="XM_002185339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE51"/>
    <dbReference type="SMR" id="B7GE51"/>
    <dbReference type="STRING" id="556484.B7GE51"/>
    <dbReference type="PaxDb" id="2850-Phatr50445"/>
    <dbReference type="GeneID" id="7199256"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50444"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008043_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE51"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="484"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="670"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="794"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114609" checksum="BDB07BB9FB06937F" modified="2009-02-10" version="1">MPSFDPIRAKMEAGGCAPSAIAAFESTYGSLVSGDSGMILEDSIAPVPQLDKTAELDIAPNATLLAETVVLKLNGGLGTGMGLDKAKSLLPVKGDDTFLDLTAKQVIQMRKEYGLNVKFMLMNSFSTSDDTLSFLSSKYPDLASEEGLEMMQNKVPKLNAETLEPASCESDPENEWCPPGHGDLYAALVGSGRLDALLKEGFKYMFVSNSDNLGASLDLEILTYFAEKNVPFLMECCERTENDKKGGHLAVRKSDGQLILRESAMCAEEDEDAFSDISKHRFFNTNNLWVRLDKLKEIIDRNGGFIPLPMIKNKKTVDPKDDSSTPVLQLETAMGAAIECFEGASAVVVPRTRFAPVKKCSDLLLLRSDAYLLVDHKPVLNPACNGSAPVINLDSKLYKLVGALEEATQDGIPSLVKCDKLTIKGLVRMSKKTKFVGDVKIVNSSAESKFVPTGEVTGEHDLTSNAGLGKLKPTSVSTAPIAGQKPGTSGLRKKVAEFKKENYLNNFVQAAFDAIKASGTDISKGSLVIGGDGRYFNPEAIQILIQMGVANGVRRFWIGQDGLLSTPAVSAIIREGGPRWQKAFGAFILTASHNPGGPTEDFGIKYNCEHGEPAPERMTDEIYANTTTIKSYKICKEFPNIDIGAAGHSKIMSDDGSAEVNIEVIDSTEAHVKLLKSIFDFSAIRGLLDRPDFSMVYDAMHGVNGPYVKKVFCDILGQDLSVTLNCVPKDDFNGGHADPNLTYAKELVAVMGLNRKGEKIDMGGRPIPSFGAAADGDGDRNMILGTQFFVSPSDSLAVIVANADTIPFFRTQGGLKGVARSMPTSGAVDLVAKDLNYSLFETPTGWKYFGNLMDSKELFDGAEYTPFICGEESFGTGSDHIREKDGLWAVLAWLSILAHANTNSLSDTLVTVEDIVKAHWAKYGRNYYSRWDFENMNATKANAMMDKMRAETDANTGKTVGKYSIEKSDDFVYVDPVDGSVAKKQGMRFLMTDGSRIIFRLSGTAGSGATVRMYIEQYEPTKIDMVASEALADLIRVALDLSDLKGFLGTEEPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEJ8</accession>
    <name>B7GEJ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_31339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185538.1">
        <property type="nucleotide sequence ID" value="XM_002185502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEJ8"/>
    <dbReference type="STRING" id="556484.B7GEJ8"/>
    <dbReference type="PaxDb" id="2850-Phatr31339"/>
    <dbReference type="GeneID" id="7199362"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31339"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_1"/>
    <dbReference type="InParanoid" id="B7GEJ8"/>
    <dbReference type="OMA" id="HWFPFVG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="482" mass="54814" checksum="396AD12097A75A46" modified="2009-02-10" version="1">MIVALVVVTGLTALWFFLLRPRTGGKHAPPVVTSSPLVPIPVIGHIVEFFRSPHFMMQRCLKDHGKVFTIPIFHKRLTFLIGPEAQEIFFKANDDVLSQSEVYDFTRPVFGNDVVYDASKKNRQVQFQTMANGLRTARLKAYIPKIEQETRAYIKNWGDAGQIDLLKALSELTILTASRCLHGEDVRTHIFKEVQELYHDLDHGLTPLTVFWPTAPSQAHRKRDVARKEMVRLFTKVIEERQLHPERSDGTDILSLFMDIKYKDGSAVTMDQVTGLLIALLFAGQHTSCITSTWTSLFIANDPTLVSRILAEQKTVLGGDLNKPIEYEDLQNMELLHNCMREALRMCPTFIMILRKAERDVKIQSEGKSYVIPQGDMVVVSPTVSMRMKETFADPDTYDPDRFAAPREEHKQPYAYMGFGGGLHSCMGQNFAFLQVKTIISVLLREYELERVEPGMPDIGYDDMVVGPKGDCTVRYRKRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3I7</accession>
    <name>B7S3I7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_bd977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999253">
        <property type="protein sequence ID" value="EEC42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176132.1">
        <property type="nucleotide sequence ID" value="XM_002176096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3I7"/>
    <dbReference type="FunCoup" id="B7S3I7">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7S3I7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft977"/>
    <dbReference type="GeneID" id="7204929"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd977"/>
    <dbReference type="eggNOG" id="KOG1475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_4_0_1"/>
    <dbReference type="InParanoid" id="B7S3I7"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="266"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="334" mass="36315" checksum="13E6A2416D9BA0CE" modified="2009-02-10" version="1">MTARPLVSVFSLSGDKSGDVSLPAVMTAPLRPDIVQFVHTNMNKNHRQAYAVNIRAGKQVVASSWGTGRAVARIPRVGGGGTSRSGQGAFGNMCRGGRMFDPTKTWRKWNKKINISQKRYAVASALAATAVPALVMSRGHVVDNVPEIPLVVENAVESAKKTSAAKDILSAIGALDDVEKAGESKQIRAGKGKMRNRRYTLRRGPLVIYKSNDGVEQAFRNLPGVELCCVDRLNLLQLAPGGHMGRFCIWSQAALEELDIIYGENGKRIPQAAMTNADLARIINSDEVQSVVNPAKPGQKEYAPKQNAIRNVEALEKLDPYAAEKRRRNFGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Y0</accession>
    <name>B7S3Y0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_bd462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999279">
        <property type="protein sequence ID" value="EEC42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176271.1">
        <property type="nucleotide sequence ID" value="XM_002176235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Y0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft462"/>
    <dbReference type="GeneID" id="7205009"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd462"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S3Y0"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="555" mass="61314" checksum="1F20944E1ECBCD95" modified="2009-02-10" version="1">MEKPMIPQFALPLKPCWNFFWQTFWPGMGLFGESYLLFSIGTLQPFWNIVYPECFTSSSDDDETDGASVCRPRLRQSLTYSIVLGVISGMLVIGYAANVIGRRKGSILTASLMSGASIALTLLSYTALSSPNLFRCMSCVLFVFGVGVGGEYPLSASSASEKAMDSSIKSPLPTSSPNRGRQVQLVFTMQGVGIFCNSLIITILIIVFGQTGDAIRDTNNYDDDVGISYSYNHNALLRIWRWTYTLGAVVLTCVWLSRIRFLPESTVWKQDKDDLEELARDALRQHHQQQMVSTITGYTTSTALFLRNYGVRLLGASLSWMLWDIAFYGNKLFQSSFLIALTGPDTTLLEFALAATLNAAVALLGYFGAAILLDVVGRRKLQQFGFLLTGTLFVACGFLYEQLSSTMLIALYLGSSFFGQLGPNATTFLIPAEIFPTSQRTMCHGIAAASGKCGALLAAVLFHYVGDVDMFLLSGYASFVACVVTYWTIPDTAGLDLYEIDRKWRMILNGRKGEYEGPANHPEFLSLHELHNHSMRHRQRQSSAYDGTVVLEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3Y6</accession>
    <name>B7S3Y6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_bd1638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="DS999280">
        <property type="protein sequence ID" value="EEC42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176277.1">
        <property type="nucleotide sequence ID" value="XM_002176241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3Y6"/>
    <dbReference type="STRING" id="556484.B7S3Y6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1638"/>
    <dbReference type="GeneID" id="7204915"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1638"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="InParanoid" id="B7S3Y6"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Prp19 coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="548" mass="58992" checksum="40A0E225FA228D71" modified="2009-02-10" version="1">MSFACEITGELLPTIDGDVVVTPSGHVCGKRLLLAKLSENGGKDPFENSRALTEDDLVTLQHFSQKSKPISIIPPNPKATSMPGLLTALQREYDSLALELFDTRKALEETRQELSQALYQNDAAVRVVARMGMERDAARQALQDYQAGANSKAPVPDPDEDNSNKKRKIEEATSNNVLKEADGDATVPFTNELPGEDLKIMIASWEVLKQTRKASQKAAAAKAPSSEAVASYALSSLQSWHKSSCRGITAMAGAKAGLPFLVTTGKDKQIVVYDWDADKVLHTVSSGSKPALSVDINEAYVVAGLATGKVELFALEGGADVGSFSVSNTPIVDVRIHPDGQHLLTASESGRVTISRFDRTQGITPISVFHPEHEEKYVCGVLHPDGLIYVAGSAFGELLLWDLKSQSLASTLKHDANDDPGITRSEENDAVTNLAFSSNGYHIASSYASGKVVVWDLRKLKALATLNTEGDDILGTVHAISFDPSGKYLAFGGPGSVRISTVKEWKITASFDVSLASCLVWGDNWLAVSSEKKREIGFFGIKTDVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7S406</accession>
    <name>B7S406_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176314.1">
        <property type="nucleotide sequence ID" value="XM_002176278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S406"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1649"/>
    <dbReference type="GeneID" id="7205126"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1649"/>
    <dbReference type="eggNOG" id="ENOG502SN9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056661_0_0_1"/>
    <dbReference type="InParanoid" id="B7S406"/>
    <dbReference type="OMA" id="QMEFFVG"/>
    <dbReference type="OrthoDB" id="45095at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002860952" evidence="2">
        <location>
            <begin position="18"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="382" mass="41571" checksum="2056E85E9BCD859C" modified="2009-02-10" version="1">MMFRVGAFALFCSLVSASSFVPSGDIPADSKLGSSLLKRATVVEPSRHLEQNSRDTTFIANYSIKYLGCSSLVQVNTQGNGQKEGNDQKDGNGGQSIVYTQNLVRFALCPSGSCSSCSGGGEYVVNMVDFVDAYTEAKLTETEYNCEQIRENCNNDDESSCYSAAGATECDQYEGQDVFEIQEYLECRQLGNQNGNDNSNNGQYTYNNYYVGPYCSSKDSKSIYLGVFYDDQCSSRANTNVYANMNSGATLPFSKESIVVSGCISCKDQQNNNNNNNNNNNNNSDQPSELCQEVYQSAAKCESAMSGSQSPDTSGCEFIDNILPRLESASLAITTGRRSGTGNAFAWLFALTTLLFGAYSYFLYRKIKRGSVTLSSQDGSMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2024-11-27" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0C9</accession>
    <name>CYF_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome f</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">petA</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="2">Binds 1 heme group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, petD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome f family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874404.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0C9"/>
    <dbReference type="SMR" id="A0T0C9"/>
    <dbReference type="STRING" id="556484.A0T0C9"/>
    <dbReference type="GeneID" id="4524601"/>
    <dbReference type="InParanoid" id="A0T0C9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.700:FF:000001">
        <property type="entry name" value="Cytochrome f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.830">
        <property type="entry name" value="Cytochrome f large domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.700">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00610">
        <property type="entry name" value="Cytb6_f_cytF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024058">
        <property type="entry name" value="Cyt-f_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002325">
        <property type="entry name" value="Cyt_f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024094">
        <property type="entry name" value="Cyt_f_lg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036826">
        <property type="entry name" value="Cyt_f_lg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33288">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33288:SF10">
        <property type="entry name" value="CYTOCHROME F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01333">
        <property type="entry name" value="Apocytochr_F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16639">
        <property type="entry name" value="Apocytochr_F_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00610">
        <property type="entry name" value="CYTOCHROMEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103431">
        <property type="entry name" value="Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49441">
        <property type="entry name" value="Cytochrome f, large domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51010">
        <property type="entry name" value="CYTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342085" description="Cytochrome f">
        <location>
            <begin position="31"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00610"/>
        </source>
    </evidence>
    <sequence length="314" mass="34262" checksum="06E2987FCDC94A93" modified="2007-01-09" version="1" precursor="true">MATNKFFKSLLFALTIAINSFGFCIQDAVAYPVFAQQNYSNPRAANGKLACANCHLNQKAIEIEAPQAVLPNSIFEVEIKVPYDTTKQQLGANGKKADLNVGGILMLPEGFKLAPKNQIPAEVKEKNKGVFISPYSSEFDNILVVGPIAGKTHQELIFPVMAPDPEKNSDIKYLTYPFYAGGNRGRGQVYPTGEKSNVNVFGANQSGQITEITVTEKGESTILILNSNGKQTSQVLPAGLILSIKQGQVVKADQPLNIDPNVGGFGQEESEIVLQNPIRIYGYLAFCFSVLITQIMLVLKKKQFEKVQAAELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3D2</accession>
    <name>B5Y3D2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_46661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185629.1">
        <property type="nucleotide sequence ID" value="XM_002185593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3D2"/>
    <dbReference type="PaxDb" id="2850-Phatr46661"/>
    <dbReference type="GeneID" id="7204490"/>
    <dbReference type="KEGG" id="pti:PHATR_46661"/>
    <dbReference type="eggNOG" id="ENOG502S0N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041622_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3D2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="57353" checksum="30AEF35F2297772A" modified="2008-11-25" version="1">MSIIGSRLTRRRAARFQSEQKYVLFLLMLAALTFWRVKRINYGTNIDATIATSDLFLLPMSLWKDTKAAPDKAALQMANENSTVPSATRANKNISILAPPPIRASKKATIAYAISVTDCKNPLDNRLVDGAAVLKHSIHLASIRNPSGTSRYDYHTYAFVHPNATQCSSILERAGYTVQMRDTPIDTDDINNTAYAERLNNPNSGCCGAREFLKLYSYTLLEYPVVVHLDVDVVILKPLDELFDIMLQPANATKHVKDAMWNKTVAHSIDSMFTRDYPMSNSVGNPNKVGMQGGFWLVRPNLTIYDEYRQIILRGDFVPGSGWGGAEYRYGGFYGAAQIQGIVPYFYGRFHPQTFVELNRCVYNQMVDIPYHEKYGKCLTGEEICQDCREANVEDIYSAHFTLCGKPWTCPSIEQHSNKSESYKWMEKVSLVGKKGELCIRLHREWHRIRHNLEVSWGIKEPIVQDPSLQPNGSISEYFYGHCKRTQTLLELDYNYVPLRFPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4M9</accession>
    <name>B5Y4M9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_10199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186321.1">
        <property type="nucleotide sequence ID" value="XM_002186285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4M9"/>
    <dbReference type="FunCoup" id="B5Y4M9">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y4M9"/>
    <dbReference type="PaxDb" id="2850-Phatr10199"/>
    <dbReference type="GeneID" id="7204339"/>
    <dbReference type="KEGG" id="pti:PHATR_10199"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_3_1"/>
    <dbReference type="InParanoid" id="B5Y4M9"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="203" mass="22470" checksum="2159BDF16B4FEC52" modified="2008-11-25" version="1">MIRIQNMSSTVNLGTRLDLKKIALKCRNTEFNPRRFGAVIMRLREPRATALIFSSGKMCVTGVKSTHNANLAAKKFAYIVERVGFKPKENIDFKVQNIVGTADVGFPIRLEGLVYAHSAFASYEPELFPGLIYRFVNPRVVFLIFVSGKIVITGAKKEMDLAHALTKLFPVLMEFKKTHITTVPGVPAASLPPTGKTVDTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Z4</accession>
    <name>B5Y4Z4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186382.1">
        <property type="nucleotide sequence ID" value="XM_002186346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Z4"/>
    <dbReference type="PaxDb" id="2850-Phatr33325"/>
    <dbReference type="GeneID" id="7204393"/>
    <dbReference type="KEGG" id="pti:PHATR_33325"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1009947_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Z4"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="47"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="28752" checksum="3A72D1A553F6D483" modified="2008-11-25" version="1">MDPVIYRWLSDCLAPKRATLEEATIAPYSSYTFHSKHSFQEEREQALRDYKVTIEYKHLKSHAPGGVYLIPALHDLRHFYGIIFVRRGPFTNGIFKFELTLSPEYNDNNQHPRIAFSSSVYNPHVHYESGELDIKSAYPRWDPSRHYLVTVLTFLKKIFYAKSFEDAKANAEARELATKYPAEFRQKVDACVLASQKQVFQNDETSTAQFSEEELSHRVLLDLLKQNIKDPTAASKQVILSMIEKASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5Q9</accession>
    <name>B5Y5Q9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186232.1">
        <property type="nucleotide sequence ID" value="XM_002186196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5Q9"/>
    <dbReference type="PaxDb" id="2850-Phatr44214"/>
    <dbReference type="GeneID" id="7203931"/>
    <dbReference type="KEGG" id="pti:PHATR_44214"/>
    <dbReference type="HOGENOM" id="CLU_1744090_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5Q9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="150" mass="16526" checksum="C04D013860A4D273" modified="2008-11-25" version="1">MTTRYNGSVATMVVQSRNHDSPLDISVDNDYPFQIHGSLHDPEVIQTGTSTERPRRGAQSAQPQSSKTIDVFKMKTAFAKPPSFRSFRPTCIHTKFLNQIKCESGGSGLEADDIIQEPLAPRHAALQEGLFFPSPVSVVEEDVSSNDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNV5</accession>
    <name>B7FNV5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_42596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176603.1">
        <property type="nucleotide sequence ID" value="XM_002176567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNV5"/>
    <dbReference type="PaxDb" id="2850-Phatr42596"/>
    <dbReference type="GeneID" id="7196283"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42596"/>
    <dbReference type="eggNOG" id="ENOG502SK10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432450_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNV5"/>
    <dbReference type="OMA" id="MAFVHYL"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="267"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70516" checksum="D0815CA9A91711C0" modified="2009-02-10" version="1">MPVYLCQPGFKTEDAWRHGIQVFAAPFPINDGGTNSSTGGGGRDLLVASVDGATTTTAKQSSIHRSLSPGQPIRRVRHAEVVIVDDICVSYNRYWLRLRWPGSKGGFAGYIAMGLVSDFDVSKEKISPGIDEDTNFIMRSAEASEDRTGAEETDVDDPTREEQPSEPFENECVVKCIRTGIEYQTSPALRLMAIYDDGISPSVSPAPFPTEPVFCRICREGLHDDADEEQPKSAAEDADDTRNSSSGTLGDEDDVEPVGVDPTDAVRDAPANKGPVIPHPHYSANSHALENPLLAPCECSGSMAFVHYLCVEQWRCRSRHPEAKNGLNCETCGTSYALPPPSARPAAPAMDQEDWLDAMPPHVLQALRQPHICWQIGAAVVRRRYLRPIAPVLMSPLVAIYCRARRLLKKRGVARRRWACSLCRRRARWKCVRCLRSYYCSRQCQNVSWHIVHKHVCYKPVRFWWSVGVYGAASLALFPGILRDPLMYDLGLGIIPLSFVILAMLGGGIASCSKSFLGMDMRGRFMEAAVVLATAFVSFVSWKLIQGFFGSPEVCHGTLGAYIVSDTTVNETYLLQFLYRVLLQPAEAYYLWCDRKALNSGLWLKAALSRTDKHNHEWLLRALAQRKRRFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP74</accession>
    <name>B7FP74_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_6915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176658.1">
        <property type="nucleotide sequence ID" value="XM_002176622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP74"/>
    <dbReference type="STRING" id="556484.B7FP74"/>
    <dbReference type="PaxDb" id="2850-Phatr6915"/>
    <dbReference type="GeneID" id="7196101"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6915"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247737_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP74"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="139" mass="15884" checksum="39FDC74AB1270F08" modified="2009-02-10" version="1" fragment="single">SKVHGWGLFADQPFIKGDVVAEYLGEYISYAVADNREKIYQEQRIQDYQFRLDEKLVIDATLKGGPARYINHNCTPNCFAKIVSGEPPSPCLKRVIIIAQQEISINEEISYDYQFPLELDLSERIPCNCQSDACRGFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPA3</accession>
    <name>B7FPA3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_6927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176673.1">
        <property type="nucleotide sequence ID" value="XM_002176637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPA3"/>
    <dbReference type="PaxDb" id="2850-Phatr6927"/>
    <dbReference type="GeneID" id="7196353"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6927"/>
    <dbReference type="eggNOG" id="ENOG502S1J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_1"/>
    <dbReference type="InParanoid" id="B7FPA3"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="163" mass="17400" checksum="576DF22D58EDE79A" modified="2009-02-10" version="1" fragment="single">IWGLLSGVAGNIYEWYDFAVYGLLAPEIGQSFFPTSSDELQLINSFGVYLAAFLMRPLGAIVFGEMGDRLVGRRNALVFSILLITIPSILMGLLPTYDTWGVAAPVLLVLLRMMQGLSVGGQLAGSYVISIEQSSPRTRGFRGSVCDASSVGGFLLASAVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPP8</accession>
    <name>B7FPP8_PHATC</name>
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        <submittedName>
            <fullName evidence="5">Regulatory proteasome non-atpase subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPN3</name>
        <name evidence="5" type="ORF">PHATRDRAFT_24692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177250.1">
        <property type="nucleotide sequence ID" value="XM_002177214.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPP8"/>
    <dbReference type="FunCoup" id="B7FPP8">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPP8"/>
    <dbReference type="PaxDb" id="2850-Phatr9320"/>
    <dbReference type="GeneID" id="7196430"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24692"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528390_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPP8"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="266"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="516" mass="57037" checksum="297F6FF96AEB2B23" modified="2009-02-10" version="1" fragment="single">MVEDTPMAEEDSLAKPENQDKVETAPSVPPLEASARRLERLLGGGAADKGQQLRAYTNPTKVIRRWLGTSSGSAADATAEDIKAAAAKLLDPAGACASGRELLVSGGEEGGEKKDSYLSAASAREVEAWLISVAVRHLWKGHKFQEAFDLAQKGIEIIMAHIDQASIHITSLSAGSTSSLFPLLSRMFRLRSLMAEALNDSNLTALLRADMSKAHNMAALRRDVDTQATILNSMLRDLLRSSQVEQAEKLLANSTFPETASNNQLCRYLYYSARIQALRLDYTASFSGLSQCLRKAPTNTGVGFRIAAQRLLVVVQMLMGDIPERHVFFTKGMKAELLPYLHITQAVRRGDLAVFTEVVSKYATRLQQDGTYTLISRLAHQVVKAGLRNLNVSYSRLSLEDVAHRLGLPSATSAEFVVAKAVRDGVLDATIHHEEGYVQSHDLVDVYATKEPALAFHRRIAYCLTTHNDAVRGMRYPPDAYKKQLEASRGNRRKRNDDKTDEEKAQELEEEYDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPY6</accession>
    <name>B7FPY6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177296.1">
        <property type="nucleotide sequence ID" value="XM_002177260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPY6"/>
    <dbReference type="PaxDb" id="2850-Phatr42897"/>
    <dbReference type="GeneID" id="7196533"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42897"/>
    <dbReference type="HOGENOM" id="CLU_626242_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPY6"/>
    <dbReference type="OMA" id="RIYSMED"/>
    <dbReference type="OrthoDB" id="48728at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="438" mass="47951" checksum="CFD4AA88C2B404E3" modified="2009-02-10" version="1">MSEAEMALQARRDAQARRQRILDAANNRMDVVNGVPTAEEEEEAARAKASAGSKMAAARRRRFQKKAPSTDAPALPEAPTEPVPLADKDSAQPVPVDETPASLPIDDTPNETTDVEDDESKIKYVGVAKMRRRMLQERKQKESRTDGANGTVKLETVKLPPKIKVSKLPILMHALTVLLLFFAGLEVGLQQAEVDYHPANIEVHTTLAPREGLRVLRRFAKSEHAGKPSLKPLDAKVSASESLAATAEEEDEFYQIDENNGADATENLDPLFGVDLDRLTEGPGLLSFLGRLAIKAHRVNLSIFYYLPQRIFYYIVDTIKSLLETPPILMLIALFIRQIVAHQILGAGLPDASQQLEGQNQTKDVLGMVKGFVSGFIFKSFPTGVKLYGAWVHLRADMYVILCGLIVGVTWCHTASLELTGVGDAVPKPSLVGTGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQF9</accession>
    <name>B7FQF9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176864.1">
        <property type="nucleotide sequence ID" value="XM_002176828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQF9"/>
    <dbReference type="STRING" id="556484.B7FQF9"/>
    <dbReference type="PaxDb" id="2850-Phatr43047"/>
    <dbReference type="GeneID" id="7196846"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43047"/>
    <dbReference type="eggNOG" id="ENOG502SG2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQF9"/>
    <dbReference type="OrthoDB" id="43280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09257">
        <property type="entry name" value="AP_muniscins_like_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37769">
        <property type="entry name" value="OS08G0243900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37769:SF1">
        <property type="entry name" value="OS08G0243900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="664" mass="73164" checksum="68FE9FBF3FA52B2F" modified="2009-02-10" version="1">MQLLHSVIVPRHEFVSFSIVLGSESAGNVHTNMAEPVLISSALSTMSTGASIEALKELHLYIIATLKASVTSATNCSFAVSLISEAQVLFDTIQTFHPKCANGLGLHYRYLKGDTKNLAGLISLILPTSKGKLAVDVAGVLLTIGSSATLKWVLSTFLLLEDDSRKTNAMVACLSVTDSPDVLTGKSKASLMNMQRLSRRMSAIGGKPSTDHDGGQLSKEEKASLMIGFNSADSTRLMTERLRVLSASENNTFLRQYRMSAQERKAHLDLTGSNKSRFRRRKSDAKDPDFDGFEYKGLKSKNSVQGSPVQTFTQEGSTKRLSLTQSKNDSRTKPLGAPRGDVVASRRLSNFASALSSGWTSVHTQDEASNMYSGGRSQAQERAPIEKEQHQFDEEGSSVALDSVASQARVHVNIALNEDLSCSYKQSQLVSCAVEGVVQVQVITNDRKETPFFLFLKDVSSQVESLQENKKFANEVLKTLGNSSDDDFFDRKYSISVPQDESYFPILRYKCISELRPVPIRVQTRVKIDDGKCRVALQISSNPNNEAGLTDLTIIMGVPEEVIGESLATQPPGGVWNQSKRSVIWVVSELGDGEKFQLQVRFEVERNLVDAIFQPTFPVLVRCQCLFSQLSDIELEVREDPARSSAAMGMKIARRFRLSHRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQI7</accession>
    <name>B7FQI7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177409.1">
        <property type="nucleotide sequence ID" value="XM_002177373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQI7"/>
    <dbReference type="PaxDb" id="2850-Phatr43070"/>
    <dbReference type="GeneID" id="7196858"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43070"/>
    <dbReference type="eggNOG" id="ENOG502STHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQI7"/>
    <dbReference type="OrthoDB" id="46457at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="239" mass="26511" checksum="892387BC28265D9B" modified="2009-02-10" version="1">MPISENNGGLGKATFFVWMVCLQQTNIAAPTASAFTIPFRVSHRLAGSVSHHHEAPAPHYLSHRQCVSRNCLFLSSEGTASSADNEVKNWTVRVRLRQATGFSLTAIRATLRTATGISLTTVYAGTVAATGAWIRQSMRLVLSIFPAWMRYFVQPFLILYYVPLFILRNLTGPTRKRALASHELVLVGWKRAIEEANRTTADWPVHLNPDGYIEKESADVDLNKAVADSVELSVNDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQM7</accession>
    <name>B7FQM7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177432.1">
        <property type="nucleotide sequence ID" value="XM_002177396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQM7"/>
    <dbReference type="PaxDb" id="2850-Phatr32251"/>
    <dbReference type="GeneID" id="7196727"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32251"/>
    <dbReference type="InParanoid" id="B7FQM7"/>
    <dbReference type="OrthoDB" id="47517at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="265" mass="29532" checksum="D3415F1F382D3F33" modified="2009-02-10" version="1">MSPPPVSVSFAEESDEESIKLDLGGGDSLAGSCGTHKQDQDEDGYSSMYFQREGLEYMTPILFEDGMDFVECSFYYLCRKSQDSGGVLYRERRRCQPRATTEQLTHMDNAQPSPCIRRPFRFHSFPSLVTDIQARRCSFSGIPDLGNNNSDSQLIRSNSMRSLRDQVARVSFEEYVQVVTIRAAHDYPEDVRSGLWISREEMAKVAELAVPKRDSTCWRMGHEVAPGSGLVEILLVSNVVVNTVTKAEGNDGTAGVTPEIGRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQZ4</accession>
    <name>B7FQZ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_9223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177492.1">
        <property type="nucleotide sequence ID" value="XM_002177456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQZ4"/>
    <dbReference type="PaxDb" id="2850-Phatr9223"/>
    <dbReference type="GeneID" id="7196571"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9223"/>
    <dbReference type="eggNOG" id="ENOG502RQIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722532_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQZ4"/>
    <dbReference type="OrthoDB" id="2122564at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="entry name" value="Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="LEUCYL/PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098:SF2">
        <property type="entry name" value="LEUCYL_PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19002" checksum="7FE75947C3857A50" modified="2009-02-10" version="1" fragment="single">MVEGFLPIATEGVLLPKLHEHRCVVTLPDRLHVSKSTRKKAKGFTISFNQAFEEVVEGCRAQHGPQCWLYPSLHQHASPLESTGKTCTIHLYSVEIWNNDRQLVGGELGYTVGSVYTSLTGFSAQDSAGSVQLAALGHLLCQLGFTLWDLGMEMEYKRNLGSQLVPRAVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR06</accession>
    <name>B7FR06_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176961.1">
        <property type="nucleotide sequence ID" value="XM_002176925.1"/>
    </dbReference>
    <dbReference type="SMR" id="B7FR06"/>
    <dbReference type="STRING" id="556484.B7FR06"/>
    <dbReference type="PaxDb" id="2850-Phatr43214"/>
    <dbReference type="GeneID" id="7196578"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43214"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR06"/>
    <dbReference type="OMA" id="HTRWWLT"/>
    <dbReference type="OrthoDB" id="39469at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="870"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="745"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1657" mass="182605" checksum="AD77E1CB4B082F9B" modified="2009-02-10" version="1">MAPQQRIEAVLDKEGTTPVLPLLQAAQHLLKPNGSIVGRDVADTIRPLFRTFCSAIPTFYEEAKTKPALASIDGRSPISHSRIHEFIVNEYGPTLHALGFGRGHRIALVLPNGPELALAIVATAQYASCVPLSANGAASELKADLLRAGVDLVVGPYSGRIHNDFIQNSQATDERFHVMPWTETDWSMFAEIEQTATGLGIPFAGLVPSPYESGIFKIVTNAATDTLRFSDRHEIICPINRSTKAFLTKENTLNDEVLVLFTSGTTGNKKLVPHQLGDILTAATTIALSWALTPDDVNCNLMPLFHVGGIVRQVFSPLVSGGCVICCPSFDPSIFWLLHVTKQAFTWYYAAPTMHQLILQTGQADGFLVEGKHCPPLRMIANAAGGLLPSLALQLRDTFVGATVLPSYGMTECMPISSPPATYQLEKPGTSGVAVGPEIAILNTTTMKSLPIGEDGPICVRGDPCFRGYGRIANDFSEAVNDTFMADGWFNTGDLGHLDKDGYLFITGRSKEVINRGGEIISPMEVEEAVLSHSDISLAAAFSAPHDVLQEVVGIVVVMMADRPRLDLASLHEFLGERLAAPKWPQCLIFMDGLPKSHTNKLLRVKLGSRLGLPELRDDMLAIDRTWEGKCPPQGTPLDVAIPVFPVSVSAEEIEEKLASMLVTTKNQNLRVIPHSTRTGSLVCYVYNLDRMDAILLARKALPRYAVPSHFVSLDTIELLSGKVLPSPSMKDAVASLLQRSSSANTIDPVVDNLQSLFAELLSLDYLPGPEANFFHIGGSSMLASQLASKLRKQFGIACSGAEIFHSTNCNDLAKLIYQRSDDFATISPIDSKLNDQSGPSGRVVDDHGAPFPSKRLAMDGSFLRSLFQLVPILIIFPIWQISRYILFFCFLLWSIDVVPGTRDIGTFIAAYLAFHLCWITITPLVFVAIKWSVIGRYKAGRYPIWGSYYLRWWFVDICRKLFLRGIWGSNEVYLNIYYRLLGAKIGKGARISLEADLAEFDLVNVGENAAVEDCTLRAFGVDNGAMILGPVHVGNNGSVGAKSVVAPFTSVPDDGHLGPVTSSYEVGKALDLKNRQFNRRCLAEPSIWLQVCLGSPITFAVNCFAQIPSLLILIWMLRYKGQRGEEFLTLNDLMEWLCDPKRIPFYIGIRVARNIVSPFFYMAAAIVAKKTVIGKFTAGPRDTWSSWSLFRHWLAATLFSRKKIQAVTDLIGRHYELVSVLYRLLGAKVGKRVFWPGSQPVFTGEFDLLEIGDDVVFGSRSGIFMTTDTSCEKVVLCAGANVADNCVVLPGSVVGKNAVLGSNSVCPLGWYLPEGSVWFGSKGCEPDCLDKGVVTDFDGPILVTDIDVKTVPMVGDATTLRPFGKAFYRGEASYSVWPLHVIIAATLLIRSILSVFHTLPLLGAIQGGGAILYGLPLIDRVYDSHEYNFFHVYFAILFVFFFTHALRVALWLVIELTAKWTLMGRREEGRYNYDTSSYAQRWELYQLISKVRKFNRLNFLDFLSGTPFMAAYFRLNGGRIGRDCCLFPAGADPFMPEPDLVTMGDRCVVDCASIVCHLNTRGNFELARITLENECTLRTRSRLQQGCYMEHGSQLLEKSLAMTGEVIEANSVWQGGPASWWFQYSQRSLYMADEEETADEKTNLLKAKVSSYNVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR24</accession>
    <name>B7FR24_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_43230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176971.1">
        <property type="nucleotide sequence ID" value="XM_002176935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR24"/>
    <dbReference type="PaxDb" id="2850-Phatr43230"/>
    <dbReference type="GeneID" id="7196952"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43230"/>
    <dbReference type="eggNOG" id="ENOG502SJ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509498_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR24"/>
    <dbReference type="OMA" id="WTATHEE"/>
    <dbReference type="OrthoDB" id="46960at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="535" mass="60037" checksum="6A5D9411EC4B9CF6" modified="2009-02-10" version="1">MSQADGSPAAAASPGNDWRVAVQQSYRNGEVREIASVLASLEPGASQSSKLRLAMQFEDAVFKGATSLADYRKKLTKRLKKVQKTYVPTEPTASTQTEKELLTLRTKYGDALRYILQHSEKSIEEMHSRYGEEKGNQFKQHIDGVRVWMSDLGLLENTQLNVTMSDQHLEKLKSHLERRVENIRSHVVKLADPNQFLKETLEMTEKNCQGKASRILAVDTRKRFEQLQKKHVDPLVILQDSIARAQASVPIPTRTQNNDEHAALVHLDKMRAASTTVLAFMMMVDKSAVPRQTLTKAHTVAVEGIDFVRKVMATHRKNTKESDVTLEDAWTKPLDIPTSSVEPALEEDGSPLPKRPKLQPRKIVVRTEVLLTPGRKVPSNLLAALKRKRARLVRPPPDGQGSHLILEFGEAFVMTIYMAPLLVSLKAYSKNPPGESHSCVQSASWTATHEELRDWQGDLSVWGTKGPYEILGHVVEERLRDASAHATYVLRACFGKASKENAGEFEREILEATALLEFLQIVRTSYVPNWEDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR42</accession>
    <name>B7FR42_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_43244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176978.1">
        <property type="nucleotide sequence ID" value="XM_002176942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR42"/>
    <dbReference type="STRING" id="556484.B7FR42"/>
    <dbReference type="PaxDb" id="2850-Phatr43244"/>
    <dbReference type="GeneID" id="7196963"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43244"/>
    <dbReference type="eggNOG" id="ENOG502SU0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1285493_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR42"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18593" checksum="28478158F5273868" modified="2009-02-10" version="1">MQGLAEVAGDPHRVQESQQKLERDVAPLAKEVQRQLHDTGREELFYQAPDIESSPHDMDRLISSSDDLLRESQSILAETEYIGTNTIMQMGQQREQLQNANLNLEAVQRVTAQAKRLMVGMSRKLLKTKLGLYFTIGVLSVANLWVLVKIYQKHHGTTGDGHDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRF1</accession>
    <name>B7FRF1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_50645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177031.1">
        <property type="nucleotide sequence ID" value="XM_002176995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRF1"/>
    <dbReference type="FunCoup" id="B7FRF1">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FRF1"/>
    <dbReference type="PaxDb" id="2850-Phatr50645"/>
    <dbReference type="GeneID" id="7196666"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50645"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="B7FRF1"/>
    <dbReference type="OMA" id="YLVMESR"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="332" mass="37317" checksum="4F12D25F2A9D6CE3" modified="2009-02-10" version="1">MADDAAGDANGGALLSDPVDVIIDKLLSVRGARPGKQVDLSEAEIKMLCLRSRDLLIGQPMLLELEAPIKICGDVHGQYYDLLRLFEYGGFPPESNYVFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRFGIKLWKTFTDCFNCLPCAAVIDEKIFCMHGGLSPELTSLDQVKRIVRPTDVPDTGLLCDLLWSDPDKEIDGWGENDRGVSFTFGEDIVAQFLHKHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKRQRFSYQGGTQGRQGTPQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRV1</accession>
    <name>B7FRV1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_9956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177560.1">
        <property type="nucleotide sequence ID" value="XM_002177524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRV1"/>
    <dbReference type="PaxDb" id="2850-Phatr9956"/>
    <dbReference type="GeneID" id="7197082"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9956"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_4_1_1"/>
    <dbReference type="InParanoid" id="B7FRV1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22948" checksum="2E7EDE3E9717D9EF" modified="2009-02-10" version="1" fragment="single">RTKTVHFVRHGQGFHNLMADLAHAQGKEWEQFKDTPENPYLIPEILDAPLTEKGRQQAYVLQAQINGMELGQKPQLVVFSPNCRALQTGVIVFESLVGKVPFVAHEMAREESGIHVCDKRRPVSRQRTEFPQVNFGLLEADDDPLFQDDVRETRQQVADRVYQFFEWLATQDEQIVAVSSHSGWLLTVFNAMLRCDESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRV4</accession>
    <name>B7FRV4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177866.1">
        <property type="nucleotide sequence ID" value="XM_002177830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRV4"/>
    <dbReference type="PaxDb" id="2850-Phatr43321"/>
    <dbReference type="GeneID" id="7197382"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43321"/>
    <dbReference type="eggNOG" id="ENOG502SCUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507616_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRV4"/>
    <dbReference type="OrthoDB" id="44177at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="537" mass="58931" checksum="2DC65BC05082EBD7" modified="2009-02-10" version="1">MLRENGGGILDAVWRMLRLWFILESFAFANAYVVVPSYNNAYTYRSGFPPRTNTALCGVRAALQRRLSFLQKAKTTTPPSTSVSTTVPPPSVTATTDTTIPTTTTTTISSSETPNLTAPLSTLQGHAVSGTNVGELQGPETSGNIPIDATVSTAFESSLSLATQPVDGGGSNSVHNTETPSFPNRPVSLENIAPPTSSATLPSLILQRPATRVPNVDQPMYQVVPRDETKLTKMELEFRDMLRYFASYSARDLHALREPRTRALFQGVAASANEPAVYRAFEVLYQDILPLRLAGRLIFGKLQGVMQHATEAREREVQAVIQKTNLPYEDVEQVWYVFVSIATQLNHDVYLTREQLSQSGLADIATRVLGYAHVDDLLQNLQLSSDDDKNNEQVRFETLMVGLQRCVDDVCGVERCDPTALLLHMTHQLETLPPGDTVEEHKSDVRKAGYARKYDDMVAAFCSWRDRVPPASPGQPNRRMDVIRGCFVGAENEAVVSALKIVYVDYSALRVAGDLIFGIVSSFMNGQKSRGGGTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS52</accession>
    <name>B7FS52_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177605.1">
        <property type="nucleotide sequence ID" value="XM_002177569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS52"/>
    <dbReference type="STRING" id="556484.B7FS52"/>
    <dbReference type="PaxDb" id="2850-Phatr43406"/>
    <dbReference type="GeneID" id="7197425"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43406"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_4_0_1"/>
    <dbReference type="InParanoid" id="B7FS52"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134736" checksum="485347A95732BE13" modified="2009-02-10" version="1">MSRGPQFLVTQEDIDEDLIELGRSALAGYFNFPLDDWQLKAGGAICQGCNVIVCAPTGAGKTVVGEMALLHAFNGGDKGIYTTPLKALSNQKYSELCGTFPKQDTGLSTGDISINKGARITVMTTEVYRNIAWRSSTPTATLMGTNELLENTVVVLDEFHYMGQPGRGGVWEESIITSPSHTQIVGLSATLSNAAALAAWMEHVTGRRTILVEVPGQERPVPLRYLFATKEALYPLFRDPDAGPGAPKGLLGYRGDGDLPSNRQSTKKAKGFTHIMDGDDVDDDETNIKIPRGLQINPALKAAANKRMQKVNRAIERQKVRRHLSPQEDEDDWGGRKRNQSSRKMSPRDERKERERLLKNEMRRSVPSLPAILNRLKQKELLPAIFFIFSRAGCDDAARQVYQYMKGPRDPNCLLQDEREQLGIKEEQRYGTKNGKSRQRAVQRRGDLVEDSDGRTFRSKSNFISEQTLNALEMSTPLADDEFDESSPLSPDNWDFFSKAGLLSYAEVRDVASRVSRFNAGNPEIAFEDEVIEQYLFGAGSHHAGMLPAHKSFVEILYRNQLMKVVFATETLAAGINIAMNLLETSNLLQMAGRAGRRGMDTDGTCVIVATPFENHDEASRILIDPVKPISSQFSPSYSLAINLIARGEGKLDVARQLVSKSFAMWEKRKVEQHVVDAVENHGDDVSQALKVSAQDRFMKTLVDALQSQVDQRSAKFDVNRVESLLGILTDRDSLKKTSKSFVGATKMFELEYTTLSYLQKEYDALRARAEIEDSDFLSEIIAEDTKDLINQIENQRKRVETTEKEIGKHPFSIITGIANQIMEDAAFPESIVLNKALGSAREGHKRTELSSLTAQELSQFSKSAIIVTRKMRKVKTANPDVEDLFQQAEDLRNDSWNDMLSITKTLVAYGCLSIEHTLEGGESYEDQQYTISPAGINIGMLGFENSLWALVAMGGAWDVVGASAKLDDFRTAMEDFDNDEDWYQNRKGNDVLIPPKVVSIPISQKEADTLNGLLRAMDPSELAGYVASIVTDNSRGNGAPVVQLFQNLTPLQQRVIQSSLVSMERLVEVQKLYGVDEKTRSCILDISNCEVVTAWASGCSWQEALEISGSPPGDLARTLSRVLDAVRQLGNMPYSPIRKQELLDGPVVWDVSRGLHPEIRRLCRDAARLINRYPVKDPLQFEELDDEDVEILDEIEQFFEEDEIESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSA7</accession>
    <name>B7FSA7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_1862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177631.1">
        <property type="nucleotide sequence ID" value="XM_002177595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSA7"/>
    <dbReference type="STRING" id="556484.B7FSA7"/>
    <dbReference type="PaxDb" id="2850-Phatr1862"/>
    <dbReference type="GeneID" id="7197168"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1862"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_1"/>
    <dbReference type="InParanoid" id="B7FSA7"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000016">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC50445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="431" mass="46266" checksum="EC72E24D243145BF" modified="2009-02-10" version="1" fragment="single">STLVLTFAGAIVFLMQAGFAMVCAGAVRTKNVQNAMLKNLLDACGASLAFFSIGYALGFGGMEPESSKKTFVGHSQFFLMDVDDYAFWLFQYAFSAASATIVAGTLAERCQMTAYLCYSLMLTGWVYPVILHSIWNPNGWLSAYSVDPLWGSGLVDFAGSGVVHVTGGITALFATMVLGPRRGRFHDDLGHDLARPREFQAHSPALQMLGTFILWFGFYGFNIGSALISTKQGSDEAAALAGVNTTLSASAAGIVALFSNLWYLEKTTGEPLFDLKYAMNGAICGLVAISGGCGVFEPWAAVVTGAVAGVIYLLGSRGLVSMRLDDAVDAIPVHLCGGAWGILAVGLFAAPERLLSVYGRNNHPGLVYSIREGDIDGVLFGIQLIGLMFIMGWVMIIMLPFFVWLNWKGWFRSDPLEEILGLDLSYHVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTF8</accession>
    <name>B7FTF8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_33072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177837.1">
        <property type="nucleotide sequence ID" value="XM_002177801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTF8"/>
    <dbReference type="STRING" id="556484.B7FTF8"/>
    <dbReference type="PaxDb" id="2850-Phatr33072"/>
    <dbReference type="GeneID" id="7197053"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33072"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FTF8"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="235"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="872" mass="97967" checksum="EC2D4B85F268312A" modified="2009-02-10" version="1">MTFPFILDGFQQQAVVRLERSESVFVAAHTSAGKTVVAEYAVALAKQRGTRCVYTSPIKALSNQKFRDFSLKFGAENIGLITGDLQVNADDSTCLIMTTEILRSMLYRGADLVRDIEFVVFDEVHYVNDTERGVVWEEVIIMLPSYVNLIFLSATTPNTLEFSDWIGRTKRKPVFVIKTDYRPVPLSFNLWAGLKLHTVMEGRDGFLERGFASAANALLPAMAWQAQGTKQNWMSLVRFLDRENMTPTVVFSFSKKKCEEISIMLQSLDLNTAKERGAVQGFTLQTVARLSKNDSNLPQVVMVCEMVQRGIGIHHGGLLPILKEMVEILFAKSLVKILFATETFAMGVNMPARSVVFNSVRKHDGKQFRQLEPGEITQMAGRAGRRGLDKVGTVIICCFGETPPPQPMLKQMLTGSSTRLNSRFRLTYNMILNLLRVEEMSVESMIKRSFSEFATQRALTTNDFPQLLTRGIRALENRIGSEDVEEYFSTCSEILSITERLLTNVRDTEAASFEGILQKGRIVLISACRELGAILLVSSQKCNVDTTSILREEHSSPAQATENPFAGMKTRGKKGASMDNKRGSGTAKADEEVEKVLDSLMEAERAELYLRDFLKRGDSVLRSRQLFGRLEAELDQMRNYEIHRHPSLESMYSTVERKESLRSKVNTLRHLLSNESLQLFPDFLQRKAVLRKLGYIDEKETVSIKGRVACETNTCEELIVTELVFEGLLNELDPEEIVAVLSALVFQEKGKETSLSVELPERLITIALNLGRIQKDVGLDIDPAEYSESSLNFGLVHVVYEWALGVPFKSICDLTDVQEGSIVRSITRLDELCREVRNCARVVGNPTLYRKLEAASMTIKRDIVFASSLYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTJ8</accession>
    <name>B7FTJ8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178164.1">
        <property type="nucleotide sequence ID" value="XM_002178128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTJ8"/>
    <dbReference type="PaxDb" id="2850-Phatr44275"/>
    <dbReference type="GeneID" id="7197950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44275"/>
    <dbReference type="HOGENOM" id="CLU_343716_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTJ8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="91610" checksum="EE5998E0D3472060" modified="2009-02-10" version="1">METRLYLRRVQRRGQRRRRFRCWLGLGFSLAAFLPSSRALVFRAPSTISTRVKRRTVPTQLYSGTVETTNLPFVPSRAATRHGSSHSSSSLSQTLHSITNWLEQQQQQQLHLSNPNCTVSWTIQPLYGNRALLRVAIQSPDAELPVVWHWHVWSPVPIATPTDPSSRSTSLLTLPPSLLWQTTQTGIVPPLLHVAVDEWDTEGLGGALRRQLQSALTVSTNHRASRKLPNDRSHHRDTHEWKVRPISETIANDFCADRHVWGRLGPSEASSTSHTCCYGVYPDANENTNSLIAVGIFIDHDLVRFVTATPSGGKNSVADAALSRIVQALVQQHPLAGSVVPIRAYVGREWLAVEPFWQNSRFVNTQRPYPPQVAAANISTTTEHCGGRYQLVDTPPWRPGHHTDVLPNPIREELSHCSTPVEAVAALRRHGLSPVYDSGVECWQWSPGEHTVASDSPVSESSRLSSYTVNNNTGIQALLDYAALQITHDRQPPLSPLDSRSETQIMLSWPRIPMDGRDGYADNPGELVYRTPSSFGEGQAYIEVRARDKQWRSVSYVSPHQHITHAVYRVHGSGRGGYGNIDASTVGISDYLRSITGLAITALEARDRGQKNNDSQSLRVLHFGFGAGTLLRYATHIWPDSVQVAVELDAGVVRAAYEVPLIDVDSSEQRQQVRQGDALKFSLQPGEARYDCILVDVFDDADLVPSGFYDRTFLKTLRDHILNDNGFVVHNMHYGVSAINAQVQEATAAYREVFADACRVASLVSTKHEGNMLLLATKFSLNAATDAEGDLSLSNQVQWLAFRGQERWGVDFDVPHRLRGVKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTP6</accession>
    <name>B7FTP6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178454.1">
        <property type="nucleotide sequence ID" value="XM_002178418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTP6"/>
    <dbReference type="PaxDb" id="2850-Phatr44320"/>
    <dbReference type="GeneID" id="7198019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44320"/>
    <dbReference type="HOGENOM" id="CLU_576809_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTP6"/>
    <dbReference type="OrthoDB" id="48633at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="474" mass="52071" checksum="0B83F8980176C0F9" modified="2009-02-10" version="1">MTTPMFHTIVASKREMTSRKRLENQSLLLLALLLLLAAHSCASVTIDDRRRRRKNGHPLAREIRVANKAGAKFDFYWIHPETRVLAGSNTDGEGVPYGGESAVSSFVGHAFEVQELEPCKRQLCRKGYFKVNGNEDQIYTVDKDFLVTGEDHKTIARKKAADALSGCAIDHSPTSSLSSMEQLDALMACIEGKIEATVQAQQEEITFNAQIRQSMGSMMVDYVCNDTSKLETSRARFNETLTFEGTEKYDLQVLFQGRKDSKDIGSRILLANDWYTPSEAEMLLSATRQKMGASDALENDEVTVKKLLSKLELLVSHAVVYQPRYRDVNLTVQTHSNQVASAGTGETTYSTCAASESPNGICAVATTTKTSRSLAVSVTASSPTTTNATGGRPVATLFVFVQDDVGALHFPQTGVRVRPQAGQVLLAMYDDVRPNEGDSQNDPTTTFVNEYVMCAPPTNDTFTVLIDEIHLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU66</accession>
    <name>B7FU66_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_33901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178265.1">
        <property type="nucleotide sequence ID" value="XM_002178229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU66"/>
    <dbReference type="STRING" id="556484.B7FU66"/>
    <dbReference type="PaxDb" id="2850-Phatr33901"/>
    <dbReference type="GeneID" id="7197747"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33901"/>
    <dbReference type="eggNOG" id="ENOG502RRAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458206_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU66"/>
    <dbReference type="OMA" id="IDATHEC"/>
    <dbReference type="OrthoDB" id="41648at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="596" mass="64802" checksum="A091E63F7B439762" modified="2009-02-10" version="1">MLPLTTHTTHTGTFANGTDDGDNNNMVPTVADRGTCVAILTDDPDASKPWYQRLAWWCTSLPWVWATTTVLVLVVVGVTLLTIQVRADSSTTPVYDPRAHGEAYNRTAYYVALRDVLLSSSDDAPVVWTTPGSPMERALAWMTLDDPLAPLPFFESHATSDEQAKESTATTLYAYERTRLHQRFALCVLYYTWAGPTWTLEPSHGWLHRHSGIESSGRLADQSIDATHECLWLGVTCTSDNRTSDDHRVVTGLDFGTSNAALKAYGTIPEIVGRLTHLQNLLVFDQQLQGPLPTTLFLLTNLQALDVNTNRLTAIPEALGDHLVHLHTLHLYGNEFRGTLPASFTQLTLLENLRLDDNPALVQDDFWSTMLPSWPLLRTVVTSSTGLGGSLPTEIGTLRQLATVSSNFAPISGTLPTELGLCTGMVQFNVNQPQAMAATTLAGGFQGTLPTELGRWSNLRFLALRGHANLVSTLPWELASWTNVQLLDLDQTAVRGTLPAYVSRWSQLNRLVLSSTDLTGTIPSELGMLSDTLMSMELQDTDLVGTVPVGLCNGGGGVEFVISCDGSAGPNGRDGNQTTTTAAKAFLVCDCCRCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUV2</accession>
    <name>B7FUV2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM13A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178661.1">
        <property type="nucleotide sequence ID" value="XM_002178625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUV2"/>
    <dbReference type="PaxDb" id="2850-Phatr44666"/>
    <dbReference type="GeneID" id="7197888"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44666"/>
    <dbReference type="eggNOG" id="ENOG502SAFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264565_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUV2"/>
    <dbReference type="OMA" id="ASQYRRY"/>
    <dbReference type="OrthoDB" id="2161449at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM13A-like" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="FAM13A-like" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1264" mass="137320" checksum="F8F1871B1A586F4B" modified="2009-02-10" version="1">MMVLHPDANSNRPSSPSTTSSTSNSSSNNATAVAANLSSTTATTATRSESSLPIKSGSERPAVVVPQLRRRRSKGTIADLTRKSPSSGNESGLPVVTTANEGALVNSSSQASSSSTLEDSVSPQQQHLSTISSSSKDRTPQQQSPLHKNTESMEVANPSTKSFIPNKPNHVSKLALLCAQNAMRLGARTQLYLCPPGKVRRTLQSELLRHSSRFANSGSTNSSDVGLDHMVDLTRYEQDEQDFLRTSNSFQAEQDEDDEEHSSGDEDDPVSSFTFPDNSSSIVHSESREPLFTPFGRDLRLSNPNGAPVLLGGSGSLNNNGRLAFNRRKLRFFDAIAPQDSATARAYLRCELNRSKKRAALSLSRHLKRVHMEEVRRKRTAQGEIVDDLVLTETPEERALLSGTVSKLQAPMTPSLAAALLLESLKVGRPESIEGMSKCYDGIVAAGTAVLDSMESNPASQQDTGNKSRATRSEIVAALAPLLITSLEQPSGELFVLLAKLRQMCGTVRYQRRFVQRVAPCLIRPPNSAMWCLKHQNDMESILAATELILDSAMDIFSKGWYERGQLLLADTKRAETLKAAAKQLRDLSSEPTTGSLALSGTGNGLTTTARARRLKNDSGVSGANNQLAEWEVIAVDRQIRVSIANALKSDWSRSTIQSEIKSHYRRPSPVNKAALRAIPSGSSDMSPKSMVSSSPRSPARIMIPVASTPKSPPHLPSVQSSTAEVLENVFGPSFAEVNVQSERAFTPPPHNSQSNPAMPQLKVFKDDKQLEFAEAFSSSPQSNQTPPRSPHSPKKAETDTLKFTENAPALTPLSSPIRGKVIGGKEVAGASHPSSSAPTTPLSPSSIGSAEIVSYKPVSAATVPSSSGSTAHYRMLTSTAAERKRTVAACRALRAQIQRFEDAFLQLHGRSPKGAVERAPLTTTYAQYREWKRAIRADAASRIQALFRGFRTRTLLLQGNRPEILRVVSRRAGRSDFTLPDLNLPSDIGDSEPTGSLTSSTENESLFETSEKQPSGLQWASKQLRPRANSGDRSGSPGSLSSSKSQSATLSTVPSALTIQELKGMTLPELQARKRDLKSQLKQYDMHFARKHGRMPIKAEKEPIRHLYESYNFLKTQITTLEHEQRRLPPPLKSPSSSVVVFPQRTVSPTSGSESGQSATEDAGFSASPKTARGKRKVPKSASPPIASAPSAASSKSSLPTDLASLKIEKGQLHQMLRSYEKDFFREHKRQVSSFADIKPVASQYRRYKEIKRAIAAQQQMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV53</accession>
    <name>B7FV53_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_44978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178866.1">
        <property type="nucleotide sequence ID" value="XM_002178830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV53"/>
    <dbReference type="PaxDb" id="2850-Phatr44978"/>
    <dbReference type="GeneID" id="7199501"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44978"/>
    <dbReference type="eggNOG" id="ENOG502RX8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054486_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV53"/>
    <dbReference type="OMA" id="QAFRIVF"/>
    <dbReference type="OrthoDB" id="203137at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46579" checksum="17A4BFD911A3AFE5" modified="2009-02-10" version="1">MSPGQPQKQYLYESPEYVAASLGLPQSMAQPSMVTYRSVGIGIFGATMRLIGMPLEKIALFMNSSQVAGKGQFAQAVKLTFQEGYLAPYRVVGKASMTAWFLQYSVMGVAFQFFDHGISQLLGVKPVWYGKELMEPAVTEDRSFDYKVRSALARVTSPMLAACLESSVSNRAEAQRFFGPKESLAMEKKFGLGLATRTLGPAFLPNAMRNVIMCQTSFLLTPITYKLYFPQEQKNKATLFWYGLTMNIFIGNVVAITQQALWGRSLDYFKEHGKIEYRKVVQQGLQKDGMAAFFTGPKWFSRVLMNAPAQGTLPWFYNEVLPLGERTALTLVKTCLYDTFLKDSVVAPENSTRVPLQRRRSSLGSLATAHPEFIETSDDEDDVTVKRHTTKELKAFSSAHSEFKDDAAPAALTANSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV85</accession>
    <name>B7FV85_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178881.1">
        <property type="nucleotide sequence ID" value="XM_002178845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV85"/>
    <dbReference type="PaxDb" id="2850-Phatr11311"/>
    <dbReference type="GeneID" id="7199669"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1631"/>
    <dbReference type="eggNOG" id="ENOG502SIFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032095_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV85"/>
    <dbReference type="OrthoDB" id="189428at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015708">
        <property type="term" value="P:silicic acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004693">
        <property type="entry name" value="Silicon_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03842">
        <property type="entry name" value="Silic_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="48489" checksum="D34D741D5BF94332" modified="2009-02-10" version="1" fragment="single">SGIELFKCVYSMILLVFSIIVVLAAIFSEQTVATGENNVNPVLAVFLVCFLITWLAMMEGGQGALVGLQPIDKELYAVSHPRTYACTKLAHQGNNMERVIVGRQFLVVLVVFVTNLMVSSIANASVLSLPDAINETFLATGLAVTLTVIIVGQLTAQVNAANCMLDFINNYFMLFTIYTSLVIEASGLLHSVYLVQTIFSKMSGTPIESNEPSRSVFQSLLFWGRVAMSLVLLGFSFAVLLTALFNGKTNMWDGIPAIASVIIFFILMAVVGIMEGMQIALFAVVNLPKEELRKHPIAYANCGLTFSGQNLQAFLIGRQICVTVCTFVIARITSVSVNTDIGENNVFGVSDGIQNFFNTGMLGALVTTIVASLAWRIIASSLPVAFMSNPLIYLIIRLCLILEATGLCSAAWVLALLQKSLAGYQRDDVYIGTAGERVVFAKDGSELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWA9</accession>
    <name>B7FWA9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179349.1">
        <property type="nucleotide sequence ID" value="XM_002179313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWA9"/>
    <dbReference type="STRING" id="556484.B7FWA9"/>
    <dbReference type="PaxDb" id="2850-Phatr11741"/>
    <dbReference type="GeneID" id="7199927"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11741"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353198_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWA9"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000421">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48344" checksum="85AB6C3BD2499B46" modified="2009-02-10" version="1" fragment="single">LPALRDGPPTKREELFVAKLKLCSVIFSFDDPTADKRGKDMKRQTLLELVDFVNTPAGQKVFTESVMGDLMAMVSANVCRALPPATDDFDPEEDEPVLEPAWPHLQVAYEFFLRFIVSSEVNAKAAKKYVDQKFCLQLVELFDSEDPRERDYLKTILHRIYGKFMSHRSFIRRAISNVFYRFVYETERHNGIGELLEILGSIINGFAIPLKKEHLQFLARALIPLHKPKCVALYHQQLSYCIIQYVEKDADTATPILNGFFKCWPWSNSGKQVMFLNELEEILELLGADQLAQVSTMLFTNLARCLDSDHFQVVERALFLWNNEHLVNSGCLSRLNAQTVLPIIYGPLYKNSSGHWNATVEGLAQNVLKMYMEYDLALYDRCTAAYFREEEEAKKKLEALQDKWALIEKEANSIAPALLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWB4</accession>
    <name>B7FWB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2267 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179352.1">
        <property type="nucleotide sequence ID" value="XM_002179316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWB4"/>
    <dbReference type="PaxDb" id="2850-Phatr45053"/>
    <dbReference type="GeneID" id="7199929"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45053"/>
    <dbReference type="HOGENOM" id="CLU_1528108_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWB4"/>
    <dbReference type="OrthoDB" id="10504901at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18909" checksum="6CAC0BCF284D70F5" modified="2009-02-10" version="1">MEELTITVAEKLGIDTAVAQKAIGAILRFVQEQSTPDLFAKIRSMDGVENLMKDDDAAEAVREGHDKAKAGGLGGGLFGLVFTLLKAFGLFAIIKQLLSTLPGIGPQAVRMIESVEDGAELTVVLKQLGIDREQGVSMVRMMMDFIKDKLDPETVDRLSSQIPAVAAFMGESKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX55</accession>
    <name>B7FX55_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179494.1">
        <property type="nucleotide sequence ID" value="XM_002179458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX55"/>
    <dbReference type="PaxDb" id="2850-Phatr45288"/>
    <dbReference type="GeneID" id="7200150"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45288"/>
    <dbReference type="eggNOG" id="ENOG502SM3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319233_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX55"/>
    <dbReference type="OrthoDB" id="48150at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="911" mass="101705" checksum="80EF1B8AEF788766" modified="2009-02-10" version="1">MPKQSRGFWTCTLCGLTFDRFQDAEYHEIEECSQRPPPPRYPPPGAMPPYETDPRTDSMPSASHYHSQMDYGPRKSRRVSLLGPQERANLSELDAVALQQVELFEAGDMYAADSSGNRTSPGQIGVRCLHCLNGPAADSFMFPADLVLVGDLVRGLVRNHVCRCDLAPGDLKGFLKRTVEREPPHERDRNRKILTDFCARRCHQFGILNRFPGNTGIHFREAEGSQQYPQMGGSERYANETGPSYGISYPMHPNQMSSNRNRSPILIEGQPPSMSPHHASPPTHESPMPMPRNSRPSPYSGRNPEGFGPSGFRPNYDVPANFPFAEEPNGEWVCKYCSHIPPEYRDPHYRWAANKGPPPGTLIDHHFSLCRAYQQSLHPIPSYGYGSKPEFPSPYPGSSPPPAVFDTTQRRSSINSYQHSASASMGGFQQFDPRDTTVEAHPGPGPVQASSMLQTELDHHEASRRTQAADYLARKDKSIYSPDGDPLPENKRLVLDEDKLLLTTYFFYLMKQLRLVRFSEADRKTRGGKRENIQVGYGGLQCVHCVEMPNSRKFFWSNVDRLANSFAEIPGHILKCRQCPQPVKDALNDLKALHASEMTQLPRGSQKVFFRRMWRRLHEQDDRNEVREATPSTPPSHAEANKPRADEETLSLEKKDSATDGSPAVTVGSGESIFLPERSTDDAAKALAEWTIQAGPPSPSSRVLLAIPEDKEWLSDTDCFIRRQIEVFCATYEDVQIALEDRKYPIQEGQVGIRCIHCAMAKDGANKEAVSYPFSISGIYESVREFQRLHLETCRNLPSGVQKKLSSLKGAASLSSVLRKYYVLAAKALGLKDTEKGVRAGGETVQVGAQAAFVFSESTPKASEDVGKDLDGEMAAQSSPETSRKRILNNEDTDREEPKKAVKLFSSERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX72</accession>
    <name>B7FX72_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_34966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179288.1">
        <property type="nucleotide sequence ID" value="XM_002179252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX72"/>
    <dbReference type="PaxDb" id="2850-Phatr34966"/>
    <dbReference type="GeneID" id="7199950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34966"/>
    <dbReference type="eggNOG" id="KOG2156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429910_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX72"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="637" mass="70552" checksum="6EC63B04A215BF07" modified="2009-02-10" version="1">MNAASLLLTQKKAMSGKKQLRGAGSHCLQSSALLGGLRDLPELGHGVDGTSSLGERVIPQRVRFGSMLELALAFVRLQFLVIPAVAFLAWNSLGVEPHRVSTAKSCQPVSSVVPFADIEHAMHVSNSMAGNITAAYEACRLWEGVFCLERDASIPPSIAAACYALQASCLVRIGRDDQALPVYDQALYLQQHLEPTAQESVRLGKAHALQRLLRYDEAVQEFRRSPPSKKAFLGAVTCSLRVRDFQGALSLVERYIDKFGSHDVDVSATLGILKYLLSSVDNSLAEKERHVLSGIQHTHPLFHWLVSLGILKRNPGNCLPVRPSMADLASINNGALDDPFLYLLDDKVRLHGILTLVPEVTETFWPETIARDGHQQQRNLNESSADELWICKQRAGYGSHGNIILRAREAQQRMRNLSPDEILQKMVDPPMLLDGHKFSLRIYVAYFMADSSTPTPLQIFLSSQGLVKIAALPYDKGAAKLDLRMHMTNSGRETSMQQEDLIFLQSLLEEDGKVSYDCLWTSIKNAVATTMKLYAKTVRKELSLNESLRIPMETLGTLGLPKILGFDFVVDCGGKAWLVEVNRFPGLQPRDTQDELTKRSVLEDAWRVTMARKSVGTFHFTNSSTGNSGLENISFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXC4</accession>
    <name>B7FXC4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_35020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179313.1">
        <property type="nucleotide sequence ID" value="XM_002179277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXC4"/>
    <dbReference type="PaxDb" id="2850-Phatr35020"/>
    <dbReference type="GeneID" id="7199976"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35020"/>
    <dbReference type="eggNOG" id="ENOG502SCSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632391_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXC4"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="8">
        <location>
            <begin position="237"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="399" mass="42950" checksum="7DD28DF9767DE817" modified="2009-02-10" version="1">MAEKTASNSSHESPLSALQEPQEIANALVRLAASLKAMASSNASAVSTGNSPRITYYRSLPPVVSQAYDLLQQGAALVHGTSTKYTLVGKIDRSDQPNLAQDLLQGCQLIGTACIICHEPASGCGVSARSHILQAARAIVNTTLQLVLSFIDESALEENVGAQKTGAVWSSCDVVLSKTVPLGNRNAIRRDLFTYIMECNETMTEFQDLIDLGPSSAEEVSANNHSETNEHGIVEVEDDGWDAFLQGQDSQFTMDELPVAVASLALVKCSRGSLNVTLQACEAAARDETSLAEFQEQGCQDRCDWICQLVEKARAVGDGMTDLGACMYPPLNLDELLAQIERQTTCIETVVLHILDASLVHGILELPDDVTELVSKVQSALATRQREALEAIVQAKAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXN6</accession>
    <name>B7FXN6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179587.1">
        <property type="nucleotide sequence ID" value="XM_002179551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXN6"/>
    <dbReference type="PaxDb" id="2850-Phatr35135"/>
    <dbReference type="GeneID" id="7200543"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35135"/>
    <dbReference type="HOGENOM" id="CLU_742860_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXN6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42177" checksum="7BC04EC68714AD92" modified="2009-02-10" version="1">MVSLSKRRTEKPKGYRPYALLGIGVVATVGVGSIIQISVPDDILSTLPEVKEYKPTTQALGRTASKHPGSTFYQYPKNTAAFVPSSTCQDGLPETDPTPFMSLDDVQQVVTKYEHEEYALERKRNFDSIGKLLYQFALEKNQMLLTVQIGGMDGKTSDPMYRMFVRRNNNKFLNHWLPVIVEPVPANFDALTETYSDVISTRKLKCRVLSNWAASYLGDSKCKFCQFDVSETAHPDCNKREKWARKQLGTLGCDYSRVFFGADFDKCIIQDEIPCGTIAELLRDKQLPDDAPIAMLQIDVEGYEHVIIPSLFDELPESALPPVIHFEHKVMRAKDELNGTKRAIEINKLLRLHGYILFDEGDNMLAIRVASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY43</accession>
    <name>B7FY43_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_20026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179870.1">
        <property type="nucleotide sequence ID" value="XM_002179834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY43"/>
    <dbReference type="FunCoup" id="B7FY43">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FY43"/>
    <dbReference type="PaxDb" id="2850-Phatr20026"/>
    <dbReference type="GeneID" id="7200629"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20026"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FY43"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000215">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000140">
        <property type="entry name" value="Lipid A export ATP-binding/permease protein MsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
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    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="285"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="621"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="646" mass="70748" checksum="767BF3F3412CD585" modified="2009-02-10" version="1">MWEVPNFIKYVKLLVLASVLAGVFSGLRGSVFTVVGGRVNVRLRIQLMDSLLSQDIGFFDTTKTGDITSRLSSDTTLVGDQVTLNVNVFLRSLVQAFGVLLCMFLISWQLSILAFISVPLITILSKWYGNYVRSLTKLMQKKLADGNSVSEAAFGSMPTVRSFDAAEAELKEFEQHMGKYLALNKRSAVAYCGYAAFTTAVPQLVFAVVVFYGGMLVRNNDISIGDLVKFLLYLQALSDAFSSIGYIFSSLTQAVGAADKVFELLHRTPRYRESSAQREAPRGEIQFENVDLYYPARPQRQVLNKLSLKVEPGSIIALVGQSGGGKSSVMSLIQHLYEQSGGRVLLDGQDVHEISPECLSRTISIVSQEPTLFARSIKRNIMYGLEGTDMEPTHEEIVEAARLANAESFIETLPQKYDTEVGERGVQLSGGQRQRLAIARALVRKPKVLLLDEATSALDAESEHLVQSAIDDMLARGKNEKGEGAMTVLIVAHRLSTVRNADTIFVIQNGQVVEEGNHGQLLENPTGAYSSLIRRQMQAQEKLDIAKTPADPNNKSASRPVNPSVKHLNRKLAPKHDGVSSQRLPTRSPTALKTNLVTDETLSRQPANTPSRKGSSVSSARITRPKSKNPKGANTESSRKNVNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYN2</accession>
    <name>B7FYN2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180002.1">
        <property type="nucleotide sequence ID" value="XM_002179966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYN2"/>
    <dbReference type="PaxDb" id="2850-Phatr45784"/>
    <dbReference type="GeneID" id="7200920"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45784"/>
    <dbReference type="HOGENOM" id="CLU_759654_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYN2"/>
    <dbReference type="OrthoDB" id="48158at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852773" evidence="2">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="328" mass="36130" checksum="934105D1360D5E17" modified="2009-02-10" version="1">MAQQAMAKWYFFLSLLLCCGHRCLALAHAPILWSTKSHRCSGRFPFATHPELIREQECVQSLRSRFLSSRLAISPTESFDEYTSVRKVEGRRKRVKVGYRVVSMGYAIFSCLVLRGGLNALTAYALSGPVMAAGISYILVGAVRNDRLSSDTYKRLNLALILYGFCGCLSAYFMPRFRTAAWMVPSFVAVVNSVKGYCYGVKGWKLESSSVIGDIVHGTRDSFRILLEKPKNASSAGYLIVTLFSVVFALLKLGNVADLALKKAVPFSIGARLLRFSKLAMLTTVSLTLKDAADRDRLEGSTFIQLNILTSAMFGAMAGTFLDSLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYQ3</accession>
    <name>B7FYQ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180014.1">
        <property type="nucleotide sequence ID" value="XM_002179978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYQ3"/>
    <dbReference type="PaxDb" id="2850-Phatr45798"/>
    <dbReference type="GeneID" id="7200810"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45798"/>
    <dbReference type="HOGENOM" id="CLU_584591_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYQ3"/>
    <dbReference type="OrthoDB" id="49632at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855512" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51345" checksum="CB677F1D084D5CFE" modified="2009-02-10" version="1">MTLPRRKFRSAWFLYQVLVQGLSVSRCLVWSADSDTSSLTPCAILGSLRSQSSHAAVPSEPLFAQPRGLQESSQPDSFLPTDELPQFRLDLPAFQVFLSPTPYEFDTETLDDLYGKIERTLWKRFETSNLSRNVLFRYLLLSDIRLEQFVNDTSIVSLGTGVVAYLGSEDSIEMETSSANGTQTRKSLLAMIEEAINGQLVETLQSSPLFEFIQVARFVSENNRTDEPTPNGVQTDDGKASASASNVNVGLLSGGIVACAALIALVGLFIYRKRDAAAQIVVVDPDEYNVKQSWKKDEDVATLGSSFDQSPPATPSQESAPPLFPTCDQSLVDESESDAFTVLTEDGDCSVIKSLAEQKSHATGVPLRSIVTTETFERDRVVQVRKDMLTSPWTGRLPSLRNSSTGKSSVSSHLDVTDEEQHRHPQRPGVASSRDLSRHVDLPPEPFVSDAFAQVNEGEEDSTVDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYS2</accession>
    <name>B7FYS2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180026.1">
        <property type="nucleotide sequence ID" value="XM_002179990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYS2"/>
    <dbReference type="PaxDb" id="2850-Phatr45816"/>
    <dbReference type="GeneID" id="7200822"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45816"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397155_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYS2"/>
    <dbReference type="OrthoDB" id="45998at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011719">
        <property type="entry name" value="CHP02058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09585">
        <property type="entry name" value="Lin0512_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="370"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="534"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="690" mass="75864" checksum="8123F5E1AE19D0F8" modified="2009-02-10" version="1">MVQNRIANISSELDERIRETAATLIGGFAKAPTASSTPMVISNNVNCATIQANAAQLSSRNATVVVLSSIGFGIDPLSSPFDATEAAVKAVRDAIERGVLRLPTASEGNLHLHVKIGVPPRITGLTEPLAVDMARIAPLLPTFLKVMPIEVVVGGLFIPPTDASTPTGVCTAVACLTLHQRVAKSSSHSSQPEAIISSPTSVTSPDSPVAPPRTWAEVEQSQHPCPMPAHDQDRIQAHDQIRQQLQKLASTHFVAPGDIEKDGFRRSTSIDMLARVSVELQEQQPTSMEGASVPRHISTNSSTSLSLEGGDGFYFNAANNYNYKKLPPGVTPKNNRRLFVRHTYRDHSSEIPAIPEEMELMSHKAPLRTPNAAFPLKLHEILSLIESDGHDDIIGWLPHGRSFKIHKHKEFVETILPKYFVMTKKSSFLRQLNLYGFNRLSGIGSDQGSYYHETFLRGMKFLSRRMQRQKVNGNGIRAAGNPDEEPTLAHFPECPVQAVLRDYAHDTSSHATDTTGDDSLTGHRQCSAVGVQVSFPLKLQRILDKLEAEDKHDVVSWLAHGRAFLVHDPDRFVSEIMPMYFNQTKYSSFQRQLHMYNFQRITAGQDKGAYHNSYFQRGKPALAIKMQRTRVNGKGTRRPGNPHAEPNLYKMESLPGIPFGAIIDVPVDMPGSGSGSYDQLDDASGSGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZA1</accession>
    <name>B7FZA1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_20332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180311.1">
        <property type="nucleotide sequence ID" value="XM_002180275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZA1"/>
    <dbReference type="STRING" id="556484.B7FZA1"/>
    <dbReference type="PaxDb" id="2850-Phatr20332"/>
    <dbReference type="GeneID" id="7200833"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20332"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="InParanoid" id="B7FZA1"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35600" checksum="F069F3556549FC83" modified="2009-02-10" version="1" fragment="single">MAAPIVTISYNELVSFDSDDPDDNLVLKVGESFGSNLNCLGILAVTDIPNFSSQRQALLPLASKLPALPDLDAVIRSETLFSTGWSHGKECLVPGRPDVAKGSFYGNPRTDSFLKDLTARDGRAELWNKLAIQHPEFYADNVWPESLPILREAFKNMGQTLLHVGVLVAAVCDVYCHRHGVETHFRDTLLRSLNCTGRLLHYFDMSENNSKEKDAMWCGWHNDHGLLTGLVPGMYIDTTTGQPVACTDNSAGLYIQTRAGSVVKVTLPSNACGFQIGETSQIQSGGILQATPHAVRPSSQSSITRESFAVFLEPEFHEPLAIPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZB8</accession>
    <name>B7FZB8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180319.1">
        <property type="nucleotide sequence ID" value="XM_002180283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZB8"/>
    <dbReference type="PaxDb" id="2850-Phatr45967"/>
    <dbReference type="GeneID" id="7200842"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45967"/>
    <dbReference type="eggNOG" id="ENOG502SMYE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800418_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZB8"/>
    <dbReference type="OMA" id="TAFRPDH"/>
    <dbReference type="OrthoDB" id="48246at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855529" evidence="3">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="37947" checksum="418201CCF200A867" modified="2009-02-10" version="1">MHRCLTQLIGFLTVFQADSFVTQSQPIGLMTTAFRPDHPLTVTVRLFGGKTEEEKESGEKTHSSKGILDFIFNPYETKIPKELEKEIYQAEGNTVAAQDRTKRVGLYAVVAFSGILLAFFNGFITELRNGPTPDGIPFALDDAGFAWVESNLLTRFLFMNKVGGGVCLVGGAAFGLLAEAEFDTRRTNAEKIWEEMQRRREGKTKKVAPRKKKRRSGKESKRLGAIAEVAFQEREGSAAVEVSAVPKAKKSTDGDIDEQQPRGNTEVSGVASEEDIGVFGALKGFYEKADKMAASQALLLNKQLEEKGLLEKITDESGLKVIGKDEAAKLKSAKTEGDASNKKDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZE9</accession>
    <name>B7FZE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_2762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180135.1">
        <property type="nucleotide sequence ID" value="XM_002180099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZE9"/>
    <dbReference type="STRING" id="556484.B7FZE9"/>
    <dbReference type="PaxDb" id="2850-Phatr2762"/>
    <dbReference type="GeneID" id="7200853"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2762"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZE9"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
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            <begin position="5"/>
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            <begin position="179"/>
            <end position="321"/>
        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="324" mass="35199" checksum="1645A1BB7DB9976B" modified="2009-02-10" version="1" fragment="single">LSFITEQVAEHTNGTIGALLNATFGNAPELLISVAALRAGFYRVVQLAMLGSMLTNMLLVFGVSCWIGGCRYQVQELRTTSGSVSVTMLLVATAGSLFPAALRLSGQMPTDNIHANVPTMEEVTFCRVNAVVMLILYVAYLVFQLGTHKEDNDESHAHVHSFSEHDVHSGGPLISMRVGVIWLFVITLCISAMSDILIETIDSFSQRMHLSQVFTSMVIIPFFSNVAEQVSAFLFAYRNEMDLCVGVTVGSAVQIATFVLPGSVLIGAVMDRSMTLYFHGYETTCLFFGTIVTVAVLQGGTSNWLTGAMMVGIYVMMATGVYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>B7FZN7_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
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                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
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            <dbReference type="EMBL" id="EEC48371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
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                <person name="Detter J.C."/>
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                <person name="Falciatore A."/>
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                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
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                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
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                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
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                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
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                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr36098"/>
    <dbReference type="GeneID" id="7201265"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36098"/>
    <dbReference type="eggNOG" id="ENOG502SVSR">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1535463_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0D6"/>
    <dbReference type="OMA" id="CANYAGE"/>
    <dbReference type="OrthoDB" id="49186at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="175" mass="20784" checksum="EAF5E0D917E96764" modified="2009-02-10" version="1">MVFLEQVIDMCCANYAGEKTDQDKNDVNETSQSSETQPKQLKYSNKDIKFDGIKYAKLLPTIRVAVKDLGFTEDSWNNGDWPACENKWFEDLTQEERRAAETLGWTKEAWDSQFKQHDWRELPENIRRAAVAAGYTEEKWKHNERPKNLDKSWNELEEEDKQHMNVLGYTRWDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0E9</accession>
    <name>B7G0E9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosylceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_54536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
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                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180669.1">
        <property type="nucleotide sequence ID" value="XM_002180633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0E9"/>
    <dbReference type="STRING" id="556484.B7G0E9"/>
    <dbReference type="PaxDb" id="2850-Phatr54536"/>
    <dbReference type="GeneID" id="7201272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54536"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_0_1_1"/>
    <dbReference type="InParanoid" id="B7G0E9"/>
    <dbReference type="OMA" id="VTNTPFC"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="173"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="806"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="94344" checksum="BD41F6FEB5E51E6E" modified="2009-02-10" version="1">MMNGRRGYTEIAAGETEPLRETSTSMISPSRTTDPSPRGRNLVCALVTVGVLLGTTLGWTRVPEDLDSSVPVGVPDSQDPTAASSTDRSIRYRPLCQFYDDTSTSVRMIQTSLKEPSRQWSDQPCFPASRHTTLFTNQRGRPPVLPLDAYGSPDAILRVNFSAVAFPTHQTPILGFGGAFTEASGRNYQRLSEQGKQAVMELLFGAQGLGYALGRVHINSCDFSVKSYTFDDVEDDFPLDHFDVGVHHDVEVGMVDMALRATSILRQGWPSEDAYEGNLRLYASPWSPPAWMKKPTWEDAKNATHAAKMTYSAEPTCLREGVGSQSRYAASWALYFSKFVTAYRDLGLPLWGVTVQNEPEFAAPWEACAYTPTTQHDFLTNHLGPQLERDHPDLKIFMFDHNKDHINIWGQKMLNASSNASRYVDGTAYHWYAGGMDRLLDGALGNANLHQFQEDMQTYGIQSNHILFNSEACHCPTTGYAGGDINIYWARAERYAHTILADLAAGSHGWVEWNLLLDSIGGPNHLGNLCESSLLAVPHRALNADPHTPPLPDFETDGPMGKVNIGDGRTREELNALGFPAKFLDVGVAVQPIYYYMGHISRYVRPGSVAVPGLVTANAQPGVRIFRPSGQVVVGGGENDLARHGMEITAWPCEGSTRQHFTWNADSKRHIQVQGHDWLGNPTKSCFARKSDPSLGTMSLTDCKPGQVGIYDIVPIAEKEGDQRFFQIVLTNHPKLDRPCLIIHQLGNDGGAYGPRGGAPVTLGSCSSKAARWKVDETTGEASSTFFSDDDGNENEVCMTTGWPFLQMGAFLTPNGEVPKTVVILNEAKESANFAIQDQDKVIVTASIPPRSIQTILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0S7</accession>
    <name>B7G0S7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180534.1">
        <property type="nucleotide sequence ID" value="XM_002180498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0S7"/>
    <dbReference type="PaxDb" id="2850-Phatr46309"/>
    <dbReference type="GeneID" id="7201499"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46309"/>
    <dbReference type="HOGENOM" id="CLU_1182159_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0S7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="25638" checksum="C26B7C44FB62E1D6" modified="2009-02-10" version="1">MERRYVYPREYAPEIDARIVSARGSYTNDMFRQIAQTSSGIACYPTAPHTHSDRDRSSIGEHPNGSISVNKEREEEMVHFAFERSHQDSDLGIIASSTITSCSWIDQCLENCLNCRGCNSLPFNSNSLVDGLTTVRLAEEEPEKELIHLAMELSCKGENERLPRIQHNSENVERMTRVERKMFELAMERSIADSEASLRSRYMKRCNDRIDFEILGNQKLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Y5</accession>
    <name>B7G0Y5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_20755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180756.1">
        <property type="nucleotide sequence ID" value="XM_002180720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Y5"/>
    <dbReference type="SMR" id="B7G0Y5"/>
    <dbReference type="STRING" id="556484.B7G0Y5"/>
    <dbReference type="PaxDb" id="2850-Phatr20755"/>
    <dbReference type="GeneID" id="7201902"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20755"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_3_1"/>
    <dbReference type="InParanoid" id="B7G0Y5"/>
    <dbReference type="OMA" id="MNTWINI"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28300" checksum="928DDB39DD1AE808" modified="2009-02-10" version="1">MVEYGSIPQTEPQITDAPPPPLRSQLTAELIGTAILVQVGCGANCLAIYLGVLDGMWQAAIVWILGATLGLYSSAALSGGHLNPAVTLSFAVVRPADFPYANVLPYWAAQLAGAFLGALTNLIVYHEAILSYEAKNGIVRGGQASIQSAAAFGDYWSLSKYVTSGWHAFLLEAFGTAFLVFCIFMLTNKKNSVPSAAVPPLVAIAIGSMVVLLGPMTGAGINPARDMGPRLATLLAGWRTAAFANWIVYFTAPLMGGPIGALIADRLLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1U2</accession>
    <name>B7G1U2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_36606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180913.1">
        <property type="nucleotide sequence ID" value="XM_002180877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1U2"/>
    <dbReference type="STRING" id="556484.B7G1U2"/>
    <dbReference type="PaxDb" id="2850-Phatr36606"/>
    <dbReference type="GeneID" id="7201735"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36606"/>
    <dbReference type="eggNOG" id="KOG3038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_812518_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1U2"/>
    <dbReference type="OMA" id="QEWIVAT"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17015">
        <property type="entry name" value="ING_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="38707" checksum="283866C06CC7CAC0" modified="2009-02-10" version="1">MSVAATHNPFRFPFHGGRRIGHHGLIRSVADVYSLFWRFTGTFSNPLILDYNNTDHPDSMSSDETYLEAFIETLSTLPHEVRRNMDLIKDLDKASGVRGETLRQLQQRYIHQAEDKMMQLELVEREDGTHGVRVIDGTEVIIPTTYELVEYVQNAELERQIQQAQEDCLQKADEKIAIAQQALDRIDAVCQRLDHDLGAMELLLQNTGDFQTQETKTAKPNDLAACQITPESEWILAKVVTFDPQTGVYKLADEDVESNKLFTLPESQVIILYAIEKLRAGDSVYAVYPDTTSFYPATVVQAPRKASTPFVTVNFVDDSDEFGVTHDKFVPLKYTMPPPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G248</accession>
    <name>B7G248_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_47005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181313.1">
        <property type="nucleotide sequence ID" value="XM_002181277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G248"/>
    <dbReference type="STRING" id="556484.B7G248"/>
    <dbReference type="PaxDb" id="2850-Phatr47005"/>
    <dbReference type="GeneID" id="7202105"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47005"/>
    <dbReference type="eggNOG" id="ENOG502THBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415353_0_0_1"/>
    <dbReference type="InParanoid" id="B7G248"/>
    <dbReference type="OMA" id="CMEISAI"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855633" description="Prenylcysteine lyase domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="401"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="573" mass="62382" checksum="FDE463AC357B8C85" modified="2009-02-10" version="1">MMFQPTLLLTSALIFPGGIGAQNIAIIGGGISGSFASKYLVSYDVNCSIDSISIFEAMPATRSANVTIAPSDDWQGSRVSSVRLRDGSVVELGASIGYEGFHLILDMIRGDSSIKLGKPYNIGTSEVDKRIRDGLGIFNGHGEWNLLTSREFKIISKLKLLWRYNYDLVKLSKFCRQALKKFADVPSLLASLEPNTFFASPDALWDALGLKKAVHSSFDDLLDALALPSEVPWYKRYIPYQGSLRSELLTAINLVNYNQDNSQVNGIVGLGSFAATTGSLFSVEGGNHKIIQSATNQAISISLQQCDGKAQVQQVPKRVSTVVGGSATSFSLFSGQEKLGNFDIVVIAAPLQQAQIEFMVQSNFDKAVLQPMPLTELVDPDLRETKDGHAALPTRLPDSAFRPYTQVVTTVLANATISEEHFNLSQEQLPRSVYTTSKGKASLHNITAITQLSSKGLYKIFSNDRLDGKVLMNLFGPHHVVEYVKFWGGASGGATPDYRGRGSSVDFLLYDGAIGFDGNTVSGALYYPNAMEQSSLACMEISAIGAMAVAKLIARRLRLIMETQTKERNRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2A4</accession>
    <name>B7G2A4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181174.1">
        <property type="nucleotide sequence ID" value="XM_002181138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2A4"/>
    <dbReference type="STRING" id="556484.B7G2A4"/>
    <dbReference type="PaxDb" id="2850-Phatr47054"/>
    <dbReference type="GeneID" id="7202146"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47054"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609010_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2A4"/>
    <dbReference type="OMA" id="HPSCNEP"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="450" mass="45883" checksum="265A5A5E441E2DB8" modified="2009-02-10" version="1">MSSNDGGGEQPLNKSPGKGGKSLQLMQQRLLAQQQQQPAQSQPTAASSPPSEIPASANSLETPADPPLQAGPPGGRPKGKDFAAMSARAPKPPVLASAPTPVAPAAHASSHAAVVSNKPKGKDFTSMASRMGAPQSAPVAAVPAPSQSSAIAQLQAAQAARAAQMQAAARAAAGLPPLKTPTATTVTTTPPHIPPPKISATQRTSSTGATSVPYGSATNVGSGGASGTAQYQPPPTSWNAAHANSQPPQQQQQSMRPSQQPLAQVKHRSAPLTARRGSSGLSQPPPKVSKARDPKPSPVPTASEARVSLQGPHHAAAAYMAPLVGTRIQSLLQSLDPLYVMDPAAEEQVLQLADDFLDKVVKQSLRIAAHRGSKTLDVQDIQLVLGKQWNIVIPGLGPPMPKKPKTSTTTRPSSTVAGTKRKSSGTGAGNVTKLSKSSSSAIATTARSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2Q3</accession>
    <name>B7G2Q3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181421.1">
        <property type="nucleotide sequence ID" value="XM_002181385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2Q3"/>
    <dbReference type="PaxDb" id="2850-Phatr37305"/>
    <dbReference type="GeneID" id="7202059"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37305"/>
    <dbReference type="HOGENOM" id="CLU_1104552_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2Q3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="236" mass="26980" checksum="61D59E57AED484C0" modified="2009-02-10" version="1">MPLFSTARTKASSTNPLSSSPTKPRKLFRRQGKHRPSPTSALAPINLNYYDRPEEKTGPDFFEKYRVNVVDVTSDKPSLVQTFDPPRDEPNWFLTSPPPREQNLEPPQSQPRALRGAQKPRSSSPKPPPSEPQSRAVYCQIDGNQNSERDWRPLSEEKDEDSLEGPNRDPHPLDRVNIGRTSFRESREDKGFTLCHDVQDVVYDCTFFLRSAKDYSLDSCRGRSSPPKRHLTRMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2W2</accession>
    <name>B7G2W2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FABFa</name>
        <name evidence="20" type="ORF">PHATRDRAFT_37367</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proposed to synthesize NOD factor fatty acyl chain. Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16 18">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181453.1">
        <property type="nucleotide sequence ID" value="XM_002181417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2W2"/>
    <dbReference type="SMR" id="B7G2W2"/>
    <dbReference type="FunCoup" id="B7G2W2">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2W2"/>
    <dbReference type="PaxDb" id="2850-Phatr37367"/>
    <dbReference type="GeneID" id="7202199"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37367"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="B7G2W2"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000029">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000018">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF352">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0536">Nodulation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="19">
        <location>
            <begin position="10"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="17">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEC47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="433" mass="45177" checksum="4EC061EAB7293785" modified="2009-02-10" version="1">MSSGSNDSDPTRVVVTGLGVISGCGIGHDDFFQACLDGKSSLGVVQRFDVTHYPCQIASEVPDHMFDPNDFFVNPKNVRSNDRFTHFAVAAARQAVQDAGLGDTPETLQNPDRVGCMVGTAFGGVETFERETLKLAQKPERPKVSPFTIPALLGNTASGVIGIEIGCRGPNYGVTSACASGGHAIGEAMGMILDGHADVMIAGGTEATITPLCFAGFSAMKAMNTNCNDNPKAGSRPFDADRAGFVMGEGAGVVVLESLASAKARGARIYCELVGYGASCDAHHITTPAPEGRGLATAMEMALDQAGIAKTDVSYVNAHGTSTAYNDKFETMALKSVFGEHATNKDGTFVVSSTKSVTGHTLGAAGGLEAVVAAKSILHGMVPPTINLETPDPECDLDYVPNVKREMEVKAAMSTNLGFGGHNAAILFKKYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G394</accession>
    <name>B7G394_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181578.1">
        <property type="nucleotide sequence ID" value="XM_002181542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G394"/>
    <dbReference type="STRING" id="556484.B7G394"/>
    <dbReference type="PaxDb" id="2850-Phatr47402"/>
    <dbReference type="GeneID" id="7202543"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47402"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843238_0_0_1"/>
    <dbReference type="InParanoid" id="B7G394"/>
    <dbReference type="OMA" id="HRFANTI"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="330" mass="37301" checksum="223860894C393243" modified="2009-02-10" version="1">MLASNTGRRLLQQPLQRHNWIRSVGSVFVRKQTRSSVSDAPGSAAAKVFVSHSIPTTAGFGQRVWRAYTRRLEKSPLWTKATMAAVIFFVSDSATQLLLPQPFDPTSTSSGTESATSWKASRAFSGAGFGVIATTWLHYWWGFLEMAVGTRLPVARHRFANTITKVVLDQGIGAPCYIYSYYVLTNFLQRLHPQATWNELHTAWTETSQKASDMLWPTMFQHWRLWPAVHTLNFYYTPLHHRVLVQNTVLIGWSAYLSHLNFNDTNKLMTPNEEINVSIARRETARALAKIETQRLQHPQTDIHSSLDEAGSLDDAVVSPKRTRMSLGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G397</accession>
    <name>B7G397_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hDer1-2</name>
        <name evidence="8" type="ORF">PHATRDRAFT_37614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181749.1">
        <property type="nucleotide sequence ID" value="XM_002181713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G397"/>
    <dbReference type="FunCoup" id="B7G397">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G397"/>
    <dbReference type="PaxDb" id="2850-Phatr6076"/>
    <dbReference type="GeneID" id="7202445"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37614"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_5_1_1"/>
    <dbReference type="InParanoid" id="B7G397"/>
    <dbReference type="OMA" id="CITIVGS"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="30363" checksum="550C6885656F78D5" modified="2009-02-10" version="1">MPFAQPVQGVADAAGPDQWFKSLPVVTRYWFGATIAVTLAANFEIISSGQCAFVWPLVRYKFELWRLLSCFLYAGPFSMNTMISCYMLVTFSRQYEAGGPYNTGAGGGTADFAFMLMFGAAIMLITFPLVTAILGLPPIFCQNMISYVLYTWSRRNPTAQANIWGMPVPGNYLPFAHLALTVFMGNPYADQLHGLMCGHIYYFLVDVVPQVQGKDILHTPRFLIDAFGIGEYRPTVEAVAPPQGGGARIAGLGNAAPAQNTAAVGGGGYTWGGGGRPLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E2</accession>
    <name>B7G3E2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_14103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181603.1">
        <property type="nucleotide sequence ID" value="XM_002181567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E2"/>
    <dbReference type="STRING" id="556484.B7G3E2"/>
    <dbReference type="PaxDb" id="2850-Phatr14103"/>
    <dbReference type="GeneID" id="7202566"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14103"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3E2"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001086">
        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33396" checksum="E64D5EAE68601116" modified="2009-02-10" version="1" fragment="single">RVLLMGPRRGGKTSIQAIVFQKMSPHETLFRLEATQQTERALVDHTSLCRFTILDFPGDDYGGETMVFDGPTTLLFVVDAQDEPYDHVLQSFSNVVTRALSVNPQISIEVFIHKVDGELFLSDESKYDCRRDVMSQVSEELADAGVGMDAVQIRYHLTSIYDHSVYEAFSRVVQRLIPQLPTLENLLNVLVSTCSMEKAYLFDVVSKLYISTDSGPVDTQSVELCSDMIDVVLDVNSAYDRESASVIRLSNGMVLYLKEVDTMLALVCITRSENFRKKSLINYNIGCLKKALLALAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E3</accession>
    <name>B7G3E3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_14096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181771.1">
        <property type="nucleotide sequence ID" value="XM_002181735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E3"/>
    <dbReference type="STRING" id="556484.B7G3E3"/>
    <dbReference type="PaxDb" id="2850-Phatr14096"/>
    <dbReference type="GeneID" id="7202469"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14096"/>
    <dbReference type="eggNOG" id="KOG0910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398757_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3E3"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="78" mass="8340" checksum="E7384C84BB628EAA" modified="2009-02-10" version="1" fragment="single">TSAQIQRLVLESPVPVLLDVYADWCGPCKVLGPALEEMAIKSGGAFRLVKVNSDNERPVSTSLEVKALPSVFGLKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3E4</accession>
    <name>B7G3E4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_47445</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181772.1">
        <property type="nucleotide sequence ID" value="XM_002181736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3E4"/>
    <dbReference type="PaxDb" id="2850-Phatr47445"/>
    <dbReference type="GeneID" id="7202567"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47445"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506686_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3E4"/>
    <dbReference type="OMA" id="KHIPARY"/>
    <dbReference type="OrthoDB" id="45753at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="268"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC46986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="538" mass="60107" checksum="5C3053A6E02CC01C" modified="2009-02-10" version="1">MKQAFPNLRIRIKVIPRFFRWYACHGLVFVGLLGGSTVATAKRRADTRLSIPRQLKRSLKDLREAGSKRSREIFQNVSSVRAGGSAFDMDQFGRSVSTVLGFIAGTQTLGTILTANKNAIFDQLAVRLLEPDSVAAMHTVRKILSSVDDHGIVDVFAKYRSRDVLLSIYALSRLQDAVAENDRRRETYSAFLDNELITDLAHYSVYASVAYGWKMHFAFGGGLHLGDLQVLLKRTGIFLADLLEHKKESKAHRPAYFIVRDRSRRKLVLCIRGTLSAHDLLTDLCCSPDEYELPRSTSRSRIKTLSDYWWNGGSAHIKMRAHQGMLQASRLLKKDAEDLIRSHLKENPGFSLVLVGHSMGGGVAALLGTLWEDTFENLQVYVFGPPCVSCFGVAPTGTRNIVSVISDGDPFRSFSLGHVADLSIGVALLCDDPHLRRMILMKTNGRTKEIGALDLQWCVQTMKRMRGDMKSEKLFPPGRLLLLSSKGGMCKVREVPTEFFGELAINHKMFDVSKHIPARYESILRSILEHRGASPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3J8</accession>
    <name>B7G3J8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181628.1">
        <property type="nucleotide sequence ID" value="XM_002181592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J8"/>
    <dbReference type="PaxDb" id="2850-Phatr47495"/>
    <dbReference type="GeneID" id="7202275"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47495"/>
    <dbReference type="InParanoid" id="B7G3J8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="21784" checksum="6D18474C4AD1FC16" modified="2009-02-10" version="1">MTTIGTSIVKAIDNPVGSTRPPSVAQSASFTGHRPVTPPASIQGAPASERPRMIVLDDLDVLIAPSPDAARILAQVLAILMDTCNVLEGLDRGRGPPTVVISMQVPEFQSKYAPVWSHFVSVHLEIEAVEEECPTLTQWQLMEGEDMVVISAWAIQRKPMQKGDDKVASSIAIKFAMVQTPQGNYIRWKEDSKEEKHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3N3</accession>
    <name>B7G3N3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181644.1">
        <property type="nucleotide sequence ID" value="XM_002181608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3N3"/>
    <dbReference type="PaxDb" id="2850-Phatr47517"/>
    <dbReference type="GeneID" id="7202616"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47517"/>
    <dbReference type="eggNOG" id="KOG3765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G3N3"/>
    <dbReference type="OrthoDB" id="205012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="43097" checksum="66617341466F1A1E" modified="2009-02-10" version="1">MTAWHSSSKRGLFVGSPPFKQISTLQWSRLFLVVWALFMAATAAVFHYQVAVFTVLPDSTLRATTFVTNNSHEDEGYQKYDFKVQSQMAPTCSPLKAQDIDFTLVTQLSPDRLKLMKLHCERWGNHPISLAVAAAMDPEIILSTLSEYGCNTEMITVSLLNLYQTLHLHRETLSGDHLNALVVPAFELSKVCDPKRAPCAAHNLAKLPKTKDALLKLYETVRLPKLHVAQFNRDTNFHGHSSTRYTDWITQPARQLLHIECVTSDRYEPYIVVRHCQSLPPFQEAFVGFGQNKITWIQQVLRMGYKFYQIGEGFVIHLPHVKSPASQKWYADKRKFMRDITKLKVQKIGKAFRFWMRNEVPDNTQVSVCSQGQQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3U6</accession>
    <name>B7G3U6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181499.1">
        <property type="nucleotide sequence ID" value="XM_002181463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3U6"/>
    <dbReference type="PaxDb" id="2850-Phatr47280"/>
    <dbReference type="GeneID" id="7202365"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47280"/>
    <dbReference type="eggNOG" id="ENOG502S7ZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342396_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3U6"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="828" mass="93481" checksum="AF999FE88A850CC8" modified="2009-02-10" version="1">MSSIVFARFSRNRLPKSRPCRRCLSSSTDDNFSGSSQRKDGRRPTSKSSSRGEKLETVPTEPVLSSLSEFMKEHAKQSSRRDVVDYDLTSLIASLSKRNKKEFSEEKNSLSAYGDDSKRIKRRDVSASSGKPNEKLLFEVFKIPDAPAARSETAFEEGSFRQYSEILESIIADDPKFMRRHTAKPIADEVAEPLIVYLRSEEPEVEVGLPTFKHALKEGISVRDTNDMKTQKLVFMEKLGVSDAQHRLIEGTLIQISNRCAKEARGLPLEVIWAKVKEAGFISQRLLQNLLYISSTFATGSRQKHITYGRLTGTSTILDVLSASESSHSSDGVDEEDNVEEMLDLADEIAVYHDLLYEPTEQSILTRVRLLVAQGHAKAAENLLVEHDCGFRLRAYSPVLRLHMEQGNAKAVMHLYRRMKRLPLVHFEAETYVHLIAGLAELGYFQLQSDPIDGIEKLGFVNGAGPGLFDELLTEMAEDILELTSQHAKRLNNALAKGFPESSLEVTSSLGSVLQTSVAAGEDDFIASRVHIDQSSGHCPVSGVKLRLMSLEPEQAKAFKQNILDMATSEQDRYELKSKQKRAQRSDFILNEFMKWLDTRAGDPFTAILDGPNIGYYMQNFEGGRFSYHQLKFVVDSLESMNEKPLVILPRKYANDRIHLTIGGVMQTLKKEELQIRNYLIKTGRVYLVPPGHLDDYFWMLSSLSTQTTARNGRDLSVLPGDPGGRWPGARPMLISNDQMRDHKLDLLEPKLFRRWYSNFMVHYNFAAFVGGQCSHPDIGFNPADFFSREIQMNQRVGGASCWHFPLTDFENEWFCISIPKVIPEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4E2</accession>
    <name>B7G4E2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182058.1">
        <property type="nucleotide sequence ID" value="XM_002182022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4E2"/>
    <dbReference type="PaxDb" id="2850-Phatr47647"/>
    <dbReference type="GeneID" id="7202842"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47647"/>
    <dbReference type="eggNOG" id="ENOG502SFT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G4E2"/>
    <dbReference type="OrthoDB" id="44224at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="411" mass="44480" checksum="52E4559CD84A7FAF" modified="2009-02-10" version="1">MAFWTRSPAKYGQRGPQPRPSLFRGFRSCSDLSRMHGRPSVARFDSHKRKEERHRPAEGGDGLGIIPPNVAGTSNSPSFGSRPDFHNGIDDYRAGASKGLFPLKESEINYSPERRARTAAAAYVRPQPSVPGGYSAYTDDAHVETRRFFVPGLEGPKVRLAVGTVLLTLTAWNRYYSSLATNADNSIQESFATNPGNVLAENLALAFTILVLWQAGIEYTKQIAAAKAVVIGGNGNGQTDGSNRRADGTGNPNGQRVSYQQSWNIPVNDERWKDQCQWAANTYLALTPATEWYLVGPGKVLYSLGLMDAPSATPVAPAPTQVDEDAVAQACQVALDTVNASQSGRVALPSTHPVSTNLVAGVRPTPQNRRTVVVQRVEDNVCIVATSDQLLAAFGKSDLTWLGQLARYIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4H6</accession>
    <name>B7G4H6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181916.1">
        <property type="nucleotide sequence ID" value="XM_002181880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4H6"/>
    <dbReference type="PaxDb" id="2850-Phatr47672"/>
    <dbReference type="GeneID" id="7202870"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47672"/>
    <dbReference type="HOGENOM" id="CLU_2008371_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4H6"/>
    <dbReference type="OrthoDB" id="42858at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="76" mass="8449" checksum="E91ADB80B9CA241D" modified="2009-02-10" version="1">MSLSRRYDAGHEKRKTTDVGEFDFEVGRVYSGELSYVGASIAVSGSIHIIDEKLGNEEVGFFNLIDTTSSRRNMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4N9</accession>
    <name>B7G4N9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182107.1">
        <property type="nucleotide sequence ID" value="XM_002182071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4N9"/>
    <dbReference type="STRING" id="556484.B7G4N9"/>
    <dbReference type="PaxDb" id="2850-Phatr47725"/>
    <dbReference type="GeneID" id="7202718"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47725"/>
    <dbReference type="eggNOG" id="KOG3735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283790_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4N9"/>
    <dbReference type="OrthoDB" id="427001at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123165" checksum="47ECF6C832C4E1DC" modified="2009-02-10" version="1">MERLRVQSSALKPVSRRQQKHADVPSSKSETYPKLRKVTRRDEDPTPTSSSTASNLPNADRKRCVFGRAANGSHPVRSGKAPTIDGNLIKPTLLKIETNSDKNVSNFDKTSNSASWIKQSLRKPDKFENARKFTPTIKKGSETSDVLQNIRFGHGENDGSLELSGKGVNETLVDQLCTNLKNIRHITLLNNNLSEKAQMKLITAVIDANTIATLVLDGIEISEKNCDCIGNIFKANRTLTTFSVPLAKLPSKLESRLKRNRKIESYVKTIRQAGGMVQSRAITPRDNELVVNIVKIIGNDPSITEFVVDGDVRFQHLGSSMILDLAESLRSNYCLKTLRVTNVELGNAFLSALATSITTNFTLEEIDLSGNAITSEAVVAFCQAMPLNTTLIRVDLSRMHTPILSDDEGVVLKALKKNESVRQFQIKFRNGYSKIALEKILARNKSAKCTPAVTSFDTKLLAYLKAEAEQAETILSERQQTETDGSEQLVEDWAHLYELSKMADIFNSFDNAYEECGETTEQPTTTKKKSGKISLVDVIGSMESMSADGSFLTEAFISKYMVENKETGGLVFEFTNQFQMFKRFQIGDKARGFITKRFVDVLLAHPRTKEITHLNMANINCSDDLLEWLSKRCKTEATLLPKLHMLNLETNNISGSGVVALAETLKTSKTWRFLQAIKLENQSSLMKTEAEAALAKAMFVNCSVIRLGLRLRNLLERDRIGRYLQRNMDYLRRARREHAAKTGKIIKRSRNTMERFIDSIAANDSAIDHVEIVGDPLFLGLNRNEVLNAAKCFASNTFVMRVKLCNLKLDDKYAEELAKSLEQSRIEYLCLDSNAIGGNGIKAIVASLAKNRSVVELQIRHQTKNMAAADEEVIADLLDSNESLVKMGIDFRSHSARTKLERKLANNNAIQRKARTTDKQDSKMTSSISKIKSVEVQKLFDSVKDGNPSITEIELNNSAEFLQMEKRSRQNFYESLRENKTVKSLSLCNLQLDNTFADELAIILSVNETIRTIVLNDNEFTSAGILTIALAAAKRRNVRQLSIRNPRFKLINEHAEELLLVMERKSNFETFDIQLREETHKQRLFKILAKNSRCTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Z2</accession>
    <name>B7G4Z2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182324.1">
        <property type="nucleotide sequence ID" value="XM_002182288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Z2"/>
    <dbReference type="STRING" id="556484.B7G4Z2"/>
    <dbReference type="PaxDb" id="2850-Phatr47805"/>
    <dbReference type="GeneID" id="7203049"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47805"/>
    <dbReference type="eggNOG" id="ENOG502S3NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403081_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Z2"/>
    <dbReference type="OMA" id="TSMYMDG"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855:SF1">
        <property type="entry name" value="CLAVAMINATE SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855">
        <property type="entry name" value="DIOX_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855419" description="Copper transporter" evidence="6">
        <location>
            <begin position="24"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="73597" checksum="4B1684F424DCD122" modified="2009-02-10" version="1">MTNRLCTVLLAAGVFSESHVTFASQNTASVSDFHSVPAFTVEELSFGHRTNDLAEALRSTGMIAVKLDHHVKHNDFDIAESRRIALGGLCGCASSDASSLFQSVSGADTSLLSDGLTTRSTFATATVGGTPLQLPVEGLEKACGRETTAAMESLRDNVAVASRSFVSAVDRLRRDSSALPNSLAPILQNIQGGTYSSLASIVKASTHLEHFHLYSKQQRQAPSGMSQASDMEEVLQVHTDAGLFLSFVPGLACGNSHTSESEHFSVLIHGKLHRAVFPPDSVGIMLGAGAQHWLKNVDSLELHATHHAVQMPSGSARAWYGMMHLVPQNAIIQEDPEPKTFADMRKAMVLSGSKTHKYGGGSLQTDEALSIGCGAGSQKINDHNFGSFGVSASRRHRRRLQMVDDASVCNNSTNFYCWMSCLDIPEAQNAQGYLNEGYSLYCLDPATLSASGNRASKAMEPCIEDGVVGLAMNENCMGSWQPTAPGVVAQELALNFTTSEEEPFCYGGTSMYMDGFHWLDSTCVIYLFPEWVLSTPGKLVAACVGSIFFGMSLEGVIRGRRDLVQSIAVGWKRLFISSGIYGLQLTMGYFIMLVVMTYSGPLFMCVVLGLMFGHIAFNAKDVLKAKKQETKEGQEECCGKEDESEITDEELSPCCQGGMEKNNVTKVSANVPEGSTPCCQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G501</accession>
    <name>B7G501_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182161.1">
        <property type="nucleotide sequence ID" value="XM_002182125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G501"/>
    <dbReference type="STRING" id="556484.B7G501"/>
    <dbReference type="PaxDb" id="2850-Phatr38120"/>
    <dbReference type="GeneID" id="7203054"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38120"/>
    <dbReference type="HOGENOM" id="CLU_535850_0_0_1"/>
    <dbReference type="InParanoid" id="B7G501"/>
    <dbReference type="OrthoDB" id="202844at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="492" mass="57134" checksum="496A512CF3A27FB5" modified="2009-02-10" version="1">MTQFRKRISLFTAGLWIFAVSLIYFERKELFGIQQPTFNTTTEERFDEAYLERQLQPAKYTAVNRVKSKDGIYPASNPIVFEKYRKASTNSSRAEPRTGRFAYAFIVGGCKPESPSYRPYIYNIAISTYIQRKRGSTADVILMVQMAYASSHETLPPDDKALLERLGIQVQYIPKTKDESFYRLMLDKFRILRLTQYDRVLFMDSDALARTNLDYLFMLSYEGVLKENFILAGPTEPANGGFFLLQPRPGDWERLLDIVRVAEERGRQSLPYPHWDTTLGWGQAIPALQPYETLVSESRTKATRWGFHGAFADQGLLYHWVKYERQSVSILVNRVVQNWGTDADGQPKMKEKLIFQTLLDRVPESSHHPNFCWRTFVRVRACVPPHSDYVHFTGNRKPWKALGRTQNATTVSKTRYRRSVTTAGPREYRGQQEYRAFWYDTLRTMATELHWTMPAVESISWNRTHRAPLVKFPLHTDAATTQYAASVWSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G572</accession>
    <name>B7G572_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_47870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182363.1">
        <property type="nucleotide sequence ID" value="XM_002182327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G572"/>
    <dbReference type="PaxDb" id="2850-Phatr47870"/>
    <dbReference type="GeneID" id="7203149"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47870"/>
    <dbReference type="eggNOG" id="ENOG502SJRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685997_0_0_1"/>
    <dbReference type="InParanoid" id="B7G572"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="157"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="402" mass="45830" checksum="F2791AE9200C9B16" modified="2009-02-10" version="1">MAANGGSRPNFAAMEMESNGRSSRRDMKPMPVQSSSGSTSHPLDQLCMFLKLHLEYYPRLATALVLSIIGLLFYMFVKSFQTPMYRNRLSHDYTKIELDYNFKASQLDHWCLFGGDDACQCEDFTETISREEQQGWLPAHEANKKRIQQNVDYDVVFFGDETTEEWNGYWYNKPSQDGHLIRKYWNETFTSAGGGELEGLALGIAGDSTANLLWRMQHGELPQSLNSKVFWLLIGTNDLSRGGCSEEATVLGILRTVEEIAFSNPGSVVVIQGILPRSSRQNGSLEKVGGRAHHLFEWHHSETFKANQARRHFLLWPSIQKINQQLATFCKEHDHLVYFDVDSLFLGTLGNDHYTAKSQQIVSDLMPDYVHLSVEGHRVLGNAILRELQRIIFEDDERNDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5U6</accession>
    <name>B7G5U6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carotenoid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CRTISO3</name>
        <name evidence="3" type="ORF">PHATRDRAFT_54842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182606.1">
        <property type="nucleotide sequence ID" value="XM_002182570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5U6"/>
    <dbReference type="SMR" id="B7G5U6"/>
    <dbReference type="STRING" id="556484.B7G5U6"/>
    <dbReference type="PaxDb" id="2850-Phatr54842"/>
    <dbReference type="GeneID" id="7203415"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54842"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_4_0_1"/>
    <dbReference type="InParanoid" id="B7G5U6"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313:SF3">
        <property type="entry name" value="PROLYCOPENE ISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852945" evidence="1">
        <location>
            <begin position="31"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="595" mass="64344" checksum="9C81DC7C09B67CE9" modified="2009-02-10" version="1">MFAISSQLTLTLVGHLILLHMMENSAICSAFVPASQRTTFSNCRRSKNRVGRHGCFLLASQSATPGTTSPTPVVVGSGIGGLCAAAMLAKYGYTVAVLESHNVPGGAAHGFTARDPKIEGEFRFDTGPSFFSGINSDTPAKASNPLRTVLDAIDERVECVPYTTFGLQFPEGNFEHSCFFGAQGGLLEQLQGTTAQKEWQALMQSMGPLEKAVAALPTAALRGDIGLLLTAAPFLPNFTTLNPLENLKLTQPFSAIVNPSVSNVFTRNWLDLLCFCLSGLPAKGTITAEMAMMMGEFYAPGAVMDCPKGGAQSIVKALVRGIEKYGGEVVCNTHVQEIVVENEKAVGVVIKQGKQRVAASKAVISNLSVWDLFGSGILDTTLLPNSLVQQKLSTPLGKSFMHLHVGFRMSKGELQTLQAHYMHMEDWGRGVQDEDNAVLVSIPSVHDDTLAPEGYAVLHIYTPATEDFTRWENVQSKEAYEKLKEERSQYLWKVLTRIVPDIRERARIVRVGTPLTHQRFLRRYKGSYGPAIQAGVGSFPFAGTPIRQLLTCGDSCFPGIGVPAVAGSGLLAAHSVSWDSIGPQQDLLKTLQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G687</accession>
    <name>B7G687_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_48177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182682.1">
        <property type="nucleotide sequence ID" value="XM_002182646.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48177"/>
    <dbReference type="GeneID" id="7203506"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48177"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262600_0_0_1"/>
    <dbReference type="InParanoid" id="B7G687"/>
    <dbReference type="OMA" id="CQIILTN"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="336"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="646"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1321" mass="143521" checksum="F2A9F5881C61C5C7" modified="2009-02-10" version="1">MTTTTTTTRNVPKRDGKAHPVLEPTGEPALVTALRRVDPLLQFLSKATGQTGIPLPTLRRSLPAGYDATALLQQLQALHDRGILQFTYRRCDEQHLGDSASTTTVATTDPTTTTSPTSVTMEVGSTFTRTTTTTTIRPTLQWEDATIWIGFPPPLTAHAVVDKLHTARRGLGTLHGSTSTAARRRIVALQRILQHEATHGSDPAPVPTESSLPSPPPAGNKAWQPEPHPEDSDNDTEEPIQRDAKLARPALQKLLGLQGCRQTEPTLDKDALPVSILAAQASYAGSHASQEAAFAVLPKHTAAQIPNSLKRVFGLPVPIQGIQGTKQLYTHQAAAIASILAGTHTSVCTGTGSGKSLCFLLPTLTAAYHGHGVSLLLFPTKALAQDQLAKLTKLLQSDADLASRIRVATLDGDTAHANRAEIAQSCNVILTNPDTLHAAVLPHWKTTYGTMLSAVRFVVIDEAHMYEGAFGAHVALVLGRLARISLVAAAAVSQDYGTATAAPLRPPVFVSTSATLPWPEQHFRLLCPISSTDSVAVFTAEKDGSPRSAKHFWVWNPPILHQDGTSTGKVRFLPTHPPASMTPDEQPKASLVGKKRPRTQRNTRISSTNQAKVKSNHHGYDPQLQAFGHGPARLHRRHAADETALLLAQAVANGIRCIAFCKTRNLVEWVFERALTILQKEDSTRSLASKVESYRGGYSMLERRQIEQRLFRTELLGVVGTNALELGVDIGGIDLTLHCGYPSSYASLLQQAGRAGRGGTARLNVPSCAVVVCFNSPSEQHIWRHPKTLLSKGVSAPHTIPINSGLVQGHLLCASEEFPLTGKYTPTTIQSTAKAAKVHHDLLNDYDLFGGMDIYEEALDALRSTGSVTEEIIATPAASFGKITIYKAHPLMKKAWSRVSIRSIEPVNYAVVDISHPGQGGRTNGIHDEGAVMDTLPYSRIFYHAHPGAIITHRGRKYKVLSMTRPPAFTPENFSYGRSMSLAAFAKPTGAKYSTRPLSNMHITVVKQMERIQLEPNSSFVTRDSFGAKSVDFSYELEQADSLSSSIPSKQSNQKQEESDEAGLSSTLAGYGIVNVKRSVHGYKKLSLITRAELSRTELSLPELEFESFGVWFDTDAGALTPRLGETYGPGVHALSHAILAVAPLFAPGLVRSDLECDHSFFAPTQVMLFDERAGGSGSSERLWNYFFQPNSILDAAIKLLEECYSCCWDKTYDGGCPACLHASNCIKFNMSLSRSAAIVIGKHMLERIQSTDFYRRNADTAKSLGRTTCEAGASPRRIARKKALDKAKEMQSSKDRHFVVGRVSWPLDGDEMQCKQVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6G9</accession>
    <name>B7G6G9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_4073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182723.1">
        <property type="nucleotide sequence ID" value="XM_002182687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6G9"/>
    <dbReference type="STRING" id="556484.B7G6G9"/>
    <dbReference type="PaxDb" id="2850-Phatr4073"/>
    <dbReference type="GeneID" id="7203547"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4073"/>
    <dbReference type="eggNOG" id="KOG0503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_3_1"/>
    <dbReference type="InParanoid" id="B7G6G9"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="7">
        <location>
            <begin position="205"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="325" mass="36273" checksum="A7F979942CA9DDA8" modified="2009-02-10" version="1" fragment="single">VLVLFCGGTLIMRENQDGSLVVNDKDKAIELLLNMEPRMSEIAQLDVHYIDNIDSSNMSPERWDEIGRVIYDHYDDYVGFVITHGTDTMAFTASALSFVLGDLGKPVTITGAHIPGGRIETDARRNFVNAVKVATLSKAGVMLIFDGDVILGARSHKLSESKLDAFGPINWTLLGEIRIDVHFSQDAKERHDRPLRFRPGFETDIAVFTLFPGFPPRDIENAIKWGTKGIILRGYGSGNISYMYMDAVKLAQTKKIPIVVNTQCLEGATLMHMYDVGKQALDHGVIQAYDMSTECIITKLMWALKHADSYEQIRGIMHTNYTGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G734</accession>
    <name>B7G734_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_38878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182834.1">
        <property type="nucleotide sequence ID" value="XM_002182798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G734"/>
    <dbReference type="PaxDb" id="2850-Phatr38878"/>
    <dbReference type="GeneID" id="7203673"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38878"/>
    <dbReference type="eggNOG" id="ENOG502SRDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1279853_0_0_1"/>
    <dbReference type="InParanoid" id="B7G734"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="23818" checksum="8B28596D08ECBBFC" modified="2009-02-10" version="1">MGGDGGVIASNRRYMRGAGAADHTGDSARQTKLDPAVEKEEIQRSMKFCALSGQPLEFGKQTIVVCPYGRLYHKEAAVEALLRRKQTDQDELGGHIRGLKDLHEVHFSLLNSMPICPITGNDLNGNIPAYVVIPGKPDEVNALSKKGMEQVDKQTIVADYGPIERKIRLAPPAAILDILKNEIIQKNAEEKISRELKRGLKKRKRIEGEVLACANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7D2</accession>
    <name>B7G7D2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183126.1">
        <property type="nucleotide sequence ID" value="XM_002183090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7D2"/>
    <dbReference type="PaxDb" id="2850-Phatr48687"/>
    <dbReference type="GeneID" id="7194865"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48687"/>
    <dbReference type="HOGENOM" id="CLU_1075451_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7D2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="259" mass="28500" checksum="9A368E2E0E54AC8D" modified="2009-02-10" version="1">MNATSRISSTPSYLHATPSKRVQQKKAQVWNDQAKVSCQKKSSPRRPNSKSKPKKVTKEHKEPTHLLLKNTGIVSLAPNTRPRVLQHCRAIFWTRTPQQSFKGTDDNSTLAGAYIVTSDPTSSGASAASSISDITDNSASFFSVKIDEGGTDFERSQADADKILASHRVDSLGSEGNSDGVFRFLEAMLFPMGEMSNNVSVHRHSEGTVMTSPPEWFIQCVDPTDVEDAEADSILEGMMLSIFDEDVSFEREIAALREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7G3</accession>
    <name>B7G7G3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-4-phosphate 5-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183142.1">
        <property type="nucleotide sequence ID" value="XM_002183106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7G3"/>
    <dbReference type="STRING" id="556484.B7G7G3"/>
    <dbReference type="PaxDb" id="2850-Phatr944"/>
    <dbReference type="GeneID" id="7194932"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_944"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616062_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7G3"/>
    <dbReference type="OrthoDB" id="42911at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12169" checksum="C561243EE2C99890" modified="2009-02-10" version="1" fragment="single">YQGQFNIYGERDGQGTMTWSNGDVYEGEFFNGTRHGQGTLTFANGSEYVGCWECNYMHGVGTRRFPNGDMYVGQYYDGQRQGQGRFYFANGDMYIGAWKDDYMHGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7J6</accession>
    <name>B7G7J6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xrn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183154.1">
        <property type="nucleotide sequence ID" value="XM_002183118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7J6"/>
    <dbReference type="STRING" id="556484.B7G7J6"/>
    <dbReference type="PaxDb" id="2850-Phatr15233"/>
    <dbReference type="GeneID" id="7194702"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15233"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252846_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7J6"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="151" mass="17209" checksum="F9DC967DCDDD90D6" modified="2009-02-10" version="1" fragment="single">MGVPKFFRWLSERYPKVIQRHGCPPNAETTQEHFGTDPPANMPKPDPLSTCGLAPEIDRLYIDMNGIIHGCSHNNSEAEENGEEGVANISEDEIFRNICYYLDRVVKDIAKPKQLVYMAIDGVAPRAKLNQQRSRRYRSGKEGEIERTVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7M0</accession>
    <name>B7G7M0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183041.1">
        <property type="nucleotide sequence ID" value="XM_002183005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7M0"/>
    <dbReference type="PaxDb" id="2850-Phatr48543"/>
    <dbReference type="GeneID" id="7194716"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48543"/>
    <dbReference type="eggNOG" id="ENOG502SPXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347642_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7M0"/>
    <dbReference type="OrthoDB" id="45490at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="88212" checksum="595B913B6C71C820" modified="2009-02-10" version="1">MPWFWGRSRDNDEEESYESYTDEEYEAEDDHEDHPSLTLEDKDAETGSGVLVENLPDTDNHTDKKTGDESHVSEDLSVPQQPRETPEDSELGEDEDSREDTTRRDEEDWVPERIHVVDPSNSGTGNRHRLPSALTVGDEDEEDEDDFLPHPTGKQIASDEEEQTPMATEKQHETASGVSSSAHTDDKNEDQVTSLAEKRSLLVLAAEHDRVDIINAILTNESNTKNSSSNAATATPQTQDRETLLSTGIPPLHIAVSFGSTSAVNCLLRMGADPSIRPNVAAIQQEAANHVSETENHGISKNTAVDIPNMGRFDGISAWELAFGNGLEENSQSMSSGWSVFGSPTSTGAAATDIGNIPERSNTGAASSPLRPKPIRPVDMAPSKREAIRHAFTAEALRCIGSDEVARLQQLVDAGMPADIDIGGKDLYNWSVEMGAPACEELLRPVEAARHGTDANLETADAAASKLVTKSAVLDRPHTDQAESVPQLLNRLDELASLAKALSTCLDNMAEEVSVCHGLLLMGGGASALASHVRSLKATQEGKLAELERMQEVWENGEDELAYWVREAGSEGEAIASQWLLIPESPTKSRLPGVDCNANESLEAQRRQLQAQIGASESQIRKLRVAIADLSEENARNLEEVEARGLTGGISLVRNIRDEIREIEFALFEAKNGEATCRTKTSLIISKVQTSKNPGALSLSNQETSGESTAEKPPRKVKGLEEGQCREMADPIVGFRATSLAKQKTPESEKIATGQSRALAVRGDGDRGFFPLSLWQILLRIIGIRESSNSSRTTRRSKTNSDNNMSQPALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7X5</accession>
    <name>B7G7X5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183092.1">
        <property type="nucleotide sequence ID" value="XM_002183056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7X5"/>
    <dbReference type="STRING" id="556484.B7G7X5"/>
    <dbReference type="PaxDb" id="2850-Phatr48625"/>
    <dbReference type="GeneID" id="7194885"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48625"/>
    <dbReference type="eggNOG" id="ENOG502RBJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398186_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7X5"/>
    <dbReference type="OMA" id="MEEERWA"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="71036" checksum="4C3A0E00A8B8E7F2" modified="2009-02-10" version="1">MGTIAPLRSPLIRAGSSTTSAFQRVQNGIGHLVATAAPDTSKSSTGGTEYSTYLTRVSHQAPARLIPLQSSAVQAAGATIAYLGNYGGGILPGDTLHYRADVLSHATLALLTQGSNRVYPQSSLPQTVDGIATSPGPQTTKPSRNVLDLRVDEHALCVVTPDPVTPFRGSVLEQIQTAVIDPNASLALVDWISSGRYVRGERWEQTSLLNQTEIYFNDHDSSHPVLVDRVILDGNTGMDFRNASLQFNAYASLVLYGSRVEAVVERCHDMAASLARPYTRIRERTPNTRTQTRNSDHDNLPFDGSCLAGRVLCSVTTVPTRHADVYVARLAACSNEDLYRVFHHLLQPTAEDLGYPIYRDRIRAVTSSPVRNISAVPESTSRLEENAASVAIVPTADDHLVPPPSSDATYWNAFVLADSALPTGSFAHSAGLEAAAQLGLVAAGNNDNSMVSDLVRATATSTMQTVTPALLASHKEASSSAFGADGELDAEFITRWNHLDRNLHSLLVGNGPACRASLDQGRNLLRVVQVWFQQGTKTHTKVTTNQVLSILQARVRDDPSAGHLPTIFGAVAALLDLTAPQACQLLAYCVARDVVSAAVRLNLVGPMASVGILSDAQQAGQRGIALGRTSYENGLSGGKGSGASCAPVLDVLQPCHDLLSTRLFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G864</accession>
    <name>B7G864_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_7235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183286.1">
        <property type="nucleotide sequence ID" value="XM_002183250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G864"/>
    <dbReference type="PaxDb" id="2850-Phatr7235"/>
    <dbReference type="GeneID" id="7194996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7235"/>
    <dbReference type="eggNOG" id="ENOG502S1I9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_889852_0_0_1"/>
    <dbReference type="InParanoid" id="B7G864"/>
    <dbReference type="OrthoDB" id="495663at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018706">
        <property type="entry name" value="DUF2214_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09980">
        <property type="entry name" value="DUF2214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="153" mass="16663" checksum="EAB1CD11C6AE66CB" modified="2009-02-10" version="1" fragment="single">VGPVPSALVAYTHYVGLLLCTACIVQERALVSTTMSTSDESTLRTTNLVYWLSALVVIASGGVRVGAYGKGWEFYSHEPWFWVKLALVGVWTASSCFPTIQHILREQSKNPATGQYYPMSEALVSRMQSLYVAELTALLFIPVAATLMARGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8N0</accession>
    <name>B7G8N0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_48865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183372.1">
        <property type="nucleotide sequence ID" value="XM_002183336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8N0"/>
    <dbReference type="STRING" id="556484.B7G8N0"/>
    <dbReference type="PaxDb" id="2850-Phatr48865"/>
    <dbReference type="GeneID" id="7194950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48865"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_1_1_1"/>
    <dbReference type="InParanoid" id="B7G8N0"/>
    <dbReference type="OMA" id="LPEHKWE"/>
    <dbReference type="OrthoDB" id="38750at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016196879" description="alpha-L-fucosidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="10">
        <location>
            <begin position="391"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC45072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="57164" checksum="98253FA9EE1894AF" modified="2009-02-10" version="1">MTMSPVRKYVVPLSLLFAFMRHLVTGAYVQQGQQAEDAVPSWDDLDQRPLPVWYDQAKFGVFIHWGVFSVPAYGSEWFGSYWRDKWGNPAYQDFVEKTERANFAYPDYAHRFTAEFYQPDTWADLFAKAGAQYVVLTSKHHEGYCNWNSTAIPTTWNWNALDIGPRRDLLGDLAVAVKNVTSPHTSKVLKFGLYHSLYEWFNPLYHVDKANNFTTQHFVDLKTGAELYDLVNRYEPELIWSDGEWEAPSSYWKAREFLHWYATSSPVADTAIWNDRWGQDTLCRHGGFLTCTDRYNPDSLQPKKWENALTIDKSSWGYNRNATWEDYMTVPELVHSLVQVVAYNGNMLLNIGPAADGTIHPIFEDRLLGIGAWLKVNGEAIYETTPWRHCQNETASSVFYTRRPDRLYVHFTKWPSASLLSLERPAPTQDTTVEFLGLSSASSSWQPTLPWTGLRGTSGSSGMTIQLPSLTPDILPCEHSWVLVIRNLANLDDPPKSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8N3</accession>
    <name>B7G8N3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183501.1">
        <property type="nucleotide sequence ID" value="XM_002183465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8N3"/>
    <dbReference type="PaxDb" id="2850-Phatr48867"/>
    <dbReference type="GeneID" id="7195153"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48867"/>
    <dbReference type="HOGENOM" id="CLU_951447_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8N3"/>
    <dbReference type="OrthoDB" id="41228at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="328" mass="38457" checksum="417AF9B01F489F24" modified="2009-02-10" version="1">MTLRLGLARYLDARTRSKTSSLTIRQRYDVKAYYTMTEANEERAKQDAKYGFKSPEENRQKFEQKEWRNKAFQGVSPMDFAMQQRLRDKERKEKEAQAKAAMYRYQGKPSDDAITLRRKEQHDREKMAKETARETKSNLKDVLITETAESASRKEHFDRDNQWKETGRTTRSNLKDVNMSGAAFETEIRKEQHQRDQGYKATARETREGLKDVLITETAESASRKEHFDRDNQWKETGRTTRSNLKDVNMAVPSFETDVRKEQHTRDQGYKATQRDTRDNLRHYDDTAEDVITSVRKDQHMREQGAKATAKQTKDSLKDVNMAAAVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8S8</accession>
    <name>B7G8S8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_48900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183522.1">
        <property type="nucleotide sequence ID" value="XM_002183486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8S8"/>
    <dbReference type="FunCoup" id="B7G8S8">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G8S8"/>
    <dbReference type="PaxDb" id="2850-Phatr15423"/>
    <dbReference type="GeneID" id="7194975"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48900"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8S8"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="92"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="456" mass="50621" checksum="AB6FA08AFA491367" modified="2009-02-10" version="1">MLHQAAQRVQRVVIRTAVGTTVVVGTVEWATHFPSQGRSSQFYHDLVDHIVTPTMRRILDPETAHHAGIFFAEQGLSPRFRPSALEQRCVVSNSVFGKTFPNPIGLAAGFDKDGEVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLVEDLGIINRYGFNSQGASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGVNIGKNKNSLDAIGDYVCNIRQLSSLADYMVLNISSPNTAGLRDLQQANSLRVLLTTCLTTRNEMTHRVPLLVKLAPDLTDEELDQIANVCLEVGIDGIIITNTTNHRPADLLSKHRGEIGGLSGKPVKDQSTECIRRLFRLTDGKIPIIGVGGVGSGHDAYEKLKAGASLVQVYSMMVYQGPGVISRIRHDLATLMLENGQRSIVDVIGADHEDIFWRKREERIAQKRRRDTRISIETLPVKKTEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8X7</accession>
    <name>B7G8X7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_22868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183669.1">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="222"/>
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        <location>
            <begin position="223"/>
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            <begin position="266"/>
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        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
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    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="433"/>
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        <location>
            <begin position="475"/>
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    </feature>
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        <location>
            <begin position="518"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="551" mass="60841" checksum="F9D5DEB34A8D4710" modified="2009-02-10" version="1">MTDRASTATVAAPNASASTAGGIAWAGSLVGVNNPNNLGYRYSTPSKRYRTTLDDGDDASRDVPTNIQVQFRNRQGEDLAQTLDLPTQSTIDDLTALVHSLLENSDSHDEQQRQKQGAGKIPYSFYATILKNGVQDDVEITHTLSDLLQQHAISTEDVLQLTYQPLAVFRVRPVTRCTDTLPGHTEAVLHVQYAPDGQMLASGGGDTTVRFWDVHTSTPKYTCKQHKNHVLCVAWAPNGKRFVSADKNGVWIVWDPTKGEAVGKAVKAHRQWITSLAWEPMHLNAACDRLATSSKDGTIKIWNVRTQAQNLTLSGHTDSVESIKWSGDGFLYSASRDRTIKVWNVDRGILVRTLTGHGHRINTLALSSDYVLRTGPFDHRGTKFASEEAAQQAAQEKYEAFRAQGPERLVSGSDDFTLFLWHPQESKHAIKRLTGHQQAVNHIAFSPDGRYFASASFDKKVKIWNGFSGDFLTTLTGHVGAVYQVAWSSDSRYLVSASKDSTAKLWEMPSGKRARETLPGHADEVYALDWSPNGASVATGSKDRTIKIWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Z7</accession>
    <name>B7G8Z7_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39556</name>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC44861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002183643.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="entry name" value="Put_rhamnosyl_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11316">
        <property type="entry name" value="Rhamno_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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            <begin position="78"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC44861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="611" mass="68837" checksum="D67A43225DA550BA" modified="2009-02-10" version="1">MGDRDVPHWDSQYPSIGSLPGRGVASRNDPQGGNYRFLEDSRVILFVWSQNCISLLPLPCPYTAMGVEWSAQFFPQPRSRNSRLTNNATGTTSQRTGNRTRSMIPLVRGMRGKAVVGLVTMGLVWTWRSLRWADEGILSVAGNPLSHPLAGVSIPLPTSYPVQVLLHVIHTRFQQHQPRLVHLGRARLALFRTLCVPSLRAQTETNFLWILRVDPALSAPLRTALLAIVRDYASRNHSVLVVASNQSPERFHLHRENDYAVDDDIRNDTLWYGNMRIWQRYQQTARRTGTVVLETNLDADDGLAIDFVHTVQQRALRDFRTTPPPTAESVIGLRRLYRIYCVGQHVEWHFYAPWDRRLFDKIPDYVIQGALRTRINDRICITPGLTVASQTVPDSHVAATTPTATTTATGTVNTTATATTAPNTATIPTPPTSSPPLLPFDVVRWHHLIQEKFAACEQTSPSQLLDFHRETFVSMSSVCYEYLDNSLDTGNVTEILPTARHPWAIRARTPTSVGVEDLLRKRSRWKYSDYSASQALWTQLSPIFSVTAESLRQTHHALADDLIAILSDAIEGQCTPNHSCHDKSRTILNRVLQNEKKYGQLVVPDKLVWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G971</accession>
    <name>B7G971_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183720.1">
        <property type="nucleotide sequence ID" value="XM_002183684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G971"/>
    <dbReference type="PaxDb" id="2850-Phatr49011"/>
    <dbReference type="GeneID" id="7195273"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49011"/>
    <dbReference type="eggNOG" id="ENOG502SPI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375301_0_0_1"/>
    <dbReference type="InParanoid" id="B7G971"/>
    <dbReference type="OrthoDB" id="48216at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="719" mass="79644" checksum="BF970DAE044E6AE7" modified="2009-02-10" version="1">MPSCGMCVATSTGDECGKLSEREILQNVEELNAAIAQEEIFSKVDVSDDPPKTIEVSLLDTLPETFSNEELLLGTVKPKDSAEFLSEMITSSRISEQQRLLDPVVSKDVQLNDKRLSEFVANNDTIIESEHTSHAHFETKTELAGESLPADVVIPKREKVGMELSKTVHRDPSESLVELDFDVNPGKLYTALQRKDWDLVLMQLREFPEESSFWISRREIDGRLRWRLLPIHGALVFKAPEFIIQALLDAYPDGARATDDQGMLPIHLSYKAGSSEIVVRMLYSAFPDSLTVADRKGRTPVQLAETTYGTNREGFLCALESTNHNDVESSIEGTTAEQGNTTSITKLDRMIFLAKSDDSTTQATRPLGTGVQVEARKMNSSTAVTSTKTTIEVHGKKHELELESLRKEIQIKEGTFQQTMKELKAELENKAETSKVLMEHVTSLESQIKSRGHMERFLATKIATLDRSLKATKQAKLESENRLNEEIHKLQSNLEEAMIEGATHTRGKDEYIKALEAQLAGAKIAALAGNSVKSKKGRPTEEETLENQVASLLSLLSAPNSESSLTTASLTMRVKGLESERNDLRKTIAKLTKKLYKVASVIDGIVSQQQDLLLENGASDDDDCDDRQLVRGSKKVEKLQVQITETQDAVEDVLPHKSDDGDDERLVDRAILHVLTSSSFAEGESCDTAPFHPKCNQKGSLTLSDEEKKADDTDAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9X1</accession>
    <name>B7G9X1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183850.1">
        <property type="nucleotide sequence ID" value="XM_002183814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9X1"/>
    <dbReference type="PaxDb" id="2850-Phatr39894"/>
    <dbReference type="GeneID" id="7195530"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39894"/>
    <dbReference type="eggNOG" id="ENOG502RRB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722538_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9X1"/>
    <dbReference type="OrthoDB" id="49364at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40525" checksum="50A413415A2D3A8D" modified="2009-02-10" version="1">MSSTSHQGPGSFPHIPRAPLPTTVLLTTVAPCLRTSGALREWLGHGGGYVPRSLQCVGDPNGPGTALVTLPHAEAAAKLVAAIRHNHTDSHNHIGAHLVPVNPDIPLPPALVDPETTQTLAQALRDSLHKITRDGPSTDVTTPALAPTLPERTPDASLRPAVEPHADPEDEDPLTSPAVLNAVKAFRDQLEVQQGTKATRRKALVAQTLAQVLPAMRLRRQQEPSVTHAPTPTPLPPAAIVPTPTTTTLPVPPPPPLPAQAPPAPRGVSNLPAWMTQANLSAEPPTASATEPPPSKRPKLDTAQPFPALPPAAHAPLRDFVTAQIQHYLGEAETSLIELIVQFVLRPDGEPAQGLLPELDVLEDDAHALLQALWDHTQHLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA18</accession>
    <name>B7GA18_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_39943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183993.1">
        <property type="nucleotide sequence ID" value="XM_002183957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA18"/>
    <dbReference type="PaxDb" id="2850-Phatr39943"/>
    <dbReference type="GeneID" id="7195558"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39943"/>
    <dbReference type="eggNOG" id="ENOG502SQGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349354_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA18"/>
    <dbReference type="OrthoDB" id="46968at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="807" mass="91603" checksum="638EC7FA8789A818" modified="2009-02-10" version="1">MSYTKLLGRTIGTLIFLVSMGQIYNHERFNRTSDLSIHAARLPFLNDSYDKGQRNISQVIPYTEETADFEKSSNNSGHRQKSAPPLPSWVTEYFHWHADERQKMTPESWEERRYLVLRCLESDKRCGGTADRLHNLPVLLRLAQKSQRILFIHWEKPAPLEDFLLPQPPETSELRLDWRLPSWLKEPMQLGQIPISRLMNGTDGTGIIDSDERVVAMRSLHGSLFYDELKGPDEPSYNNILKLLWYAVFVPAPIVRVRVQLQLARLGLTPGEYASAHIRSLYIGDETHVDTLYVHAVTCAAQATNNASFPIFVTSDSPLVEEQAVVFGSAVHHLRIVTHNRSETLHLDRGRDFLTQGRSDSWKSIDMDGFYDVFVDLYLVANSRCVSFGVGGFGRLGALLSADPSCAYKYAPATRSDQCTVPKPIRNISAAKAVFTSSSLFSSPSILPIYNSTTIHSWNNTKMIPKWMKQYFCWHQDARRLLQNGEKSASDYKYLVLRCLTKNKKCSGAADRLKSIPTAIRMAYDSQRLLFLKWERPCALEHFLVPPRGGLDWRIPSTLELDFEEKFSWRDKAIVLTESNNVEKALKSEEVIVSLKSVRDRKYFEEQREPGDYSFEEVYREVWSSVFEPSPPVARLVSTVMEELGLRPGEYVAAHVRALYVQNTVKNREEINALNCASQLGPRATIFFASDSAETTRLALQYGRGKEATIVARIGESEPLHLDRGHVFLEQHGVVAGEHEPQDFYDTFVDLYILAESRCITYGAGGFGSWASLISRNSLCSIRHRTTNCVWFDDPILGSPSLSAIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN9</accession>
    <name>B7GAN9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184227.1">
        <property type="nucleotide sequence ID" value="XM_002184191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN9"/>
    <dbReference type="STRING" id="556484.B7GAN9"/>
    <dbReference type="PaxDb" id="2850-Phatr40171"/>
    <dbReference type="GeneID" id="7195937"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40171"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_744886_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAN9"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="364" mass="42024" checksum="F9B0047C217EA96D" modified="2009-02-10" version="1">MQKGVPMHRVPQPQHQRCRVKLQCLVLGAAGAGKTSLLRRYFHNAFQAGTRVPTLGSDFYTGRVPNPLQEHNSSSTDSHVLINLQMWERSCFWLKTGVNSEFFFFQDTPGRERFYSKRQRRHTDAASLGASFFRQADAVMLVYDMTSSTSFTQLLKWYADLVDLCQSKPVPILIVANKLDLFIADQQRASTWVHPRRVSQRDVLGLAGSFRGNDFRYEYRVSTQLSPNPMKKKHQRKQSHRRMEISSFLANRENWTTDGSYLESLLNSEDASHPDREMVLLWCMRNGLKHVEVSAATGEHVDGAIDELIRLALLTKQSKNCDTKADLVGIESQPLYQRNDELNVQERYQSNEDRYLFQQRKNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP1</accession>
    <name>B7GAP1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184228.1">
        <property type="nucleotide sequence ID" value="XM_002184192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP1"/>
    <dbReference type="PaxDb" id="2850-Phatr49464"/>
    <dbReference type="GeneID" id="7195938"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49464"/>
    <dbReference type="eggNOG" id="ENOG502RW25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149126_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAP1"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="242" mass="26459" checksum="7A640E0E82C54235" modified="2009-02-10" version="1">MSRLCRERTAAAKVDAATSAGHGGKSRSICATSLLPQHDNIRYGPFGSVDTVSVVSVRLKCSLQVQDRPRSQKMIRIFAKKVFTPQLTGRLMFSSNVPVTSAPATVPSVRDLLIDLTLVDPSGARRKIKGVIGRTLYEVCDMYDIDIGPASGGSAPEEARTETWFEPTFGEGTTSGYDHVVLVGKGSDKAQRMTPVEEQMLDDHWSFDEIYEGSRLASAVKLVKEMDGMTVYIPDRIVDDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAP2</accession>
    <name>B7GAP2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_40174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184111.1">
        <property type="nucleotide sequence ID" value="XM_002184075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAP2"/>
    <dbReference type="STRING" id="556484.B7GAP2"/>
    <dbReference type="PaxDb" id="2850-Phatr40174"/>
    <dbReference type="GeneID" id="7195819"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40174"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317968_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAP2"/>
    <dbReference type="OrthoDB" id="188902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="897" mass="97805" checksum="250C0090295F9C08" modified="2009-02-10" version="1">MPPKPQEHQQGEPEQDADEHHSRTSSKSSLSGREPLLFDNATLLSASGHLPSETSRSTLDGEFAVNTATEMDCDISLSIMNRPSRDVVLQRLSEALLRRSLTKFALTHFLSLAAFIKLSSLAVISKIDLSQRGIRTSDARLINMALAQNASLTTLKLGYNDLGDDGLRTLANGIARHGALESLDLGFNNIGDNGCRALAEAITAQPMSLSRLRTLYLAGNALGEDGALAIAKIVQHGSLEKLYLTGNRLGPDGVRAIAEAALELQLEKIHKVNINCVNSLQASRRGIKELFLGGTGLGGVGCQAIADLLGQSSTLQVLSLANCDLDNDSLSVLASSIKSNREQLPLESLQLSFNQISCKGVESLSNAIWGCRSLRELLLDNNQIGDRGAGQIAAVLASANRLETLNVGFNRIKAVGIKAIMKTVPESESLHSLSLSGNTVDASAARSIAYALAFNHSLLSLSLVNTSIQHEGQRHITAGIVSNSHIKLLQLNGFRIGPIVVTLGFPAALEHWSNDQILNFIHLMWDKSAELVAQQEHEAKPVFDTSRFFSKANPRDRAAPLDAAVVVDVAKKAYVELVTEGVDIFSKRPGNMHELSPLPGDNFIVESTRKVGENSYAESSLESHVQARSFVTSPELAGSETYVPDPQRKKRVIEWLCSNIQNLNKMAQQPFNSKELWALHQRYFTPVVNECGGSVNPTSETSNNQNGNPKLHASRVSRSNSTENPADMMNDSTDDTLMTQSSDPFILDSPQGIVSLPVLKRKVSYRFLGDAMVNSAPRMSNCVEMRGPETEQPISNGMVSMMIEGGPVGHSMPRKTKRARRNRTRISFLPRVKVKLDSYLDVCHEKALTMMRQLYFVERAILLGQLNSDVNSMPYSARMHLHGVLAMDAEMILVDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAR3</accession>
    <name>B7GAR3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184120.1">
        <property type="nucleotide sequence ID" value="XM_002184084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAR3"/>
    <dbReference type="STRING" id="556484.B7GAR3"/>
    <dbReference type="PaxDb" id="2850-Phatr49481"/>
    <dbReference type="GeneID" id="7195947"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49481"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287221_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAR3"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="796"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115708" checksum="BF2327E1E7965184" modified="2009-02-10" version="1">MSGRRGATANGEGSRWETSYESIMGSAIGTANADTTNATAIPGNTDETAAAEAATKALSSRLVTFRQWLTDEARVDVHPALCIVNGEATDGTRNAPVLVFEKHPTVTARHKGRVGTVDQDGDRLLWDRTMGCQVRAAREIKPEEVLMTMPRSAMISPDLVAASDAGKAVLACVSHTTGAEGFWDVFENTTLCEATFSPKVAGNTGPQLLVKILQERKKVEALFNHRKNSPATATIGAAYSLAASKGVSTRAPVLAFLIHQRFSNTSRPAVSSDVHELQMALESSDGNALRPATSVRVPSGAPKTFAPYARTLPSSVSIPLCWKRNELALLAGCIPGVSLLQEVATSTLQLAAEFAALLEAGILERFPETFPPGLLTWERWIWAAACSSSRVLPATSYLNEGDTSASTFVPTTGQELQSPPDIWNELGVMIPLLDMLNHETEAHQVTWKPCVPESNVKVEDSPGPASHPPEAIVHKRVRKGSEVYCCYGLLSNQDLILRYGFAQMNNPSDEIKIGWTLSDAVGRVKTPTDYTPLLSVDDQVYESSDSDAINTWWTQERLNLLEKEAFRGSKDSFAALQAGKKLSFVAYGDGTYHPILLTMAVVATMPPRDVREHLQEEDEKISLSIRHQRILRNYLAFTFTRKLEKLLNVLANGLHAHFNNVKLWTKATDGGLRYKSPEDTNGDYVGWQTFFDSHAYGSSMEVEKKYYAMGSDSCVLTLYDGQLRALQISIEGAVDEEKFQESVLKQICDLGFALGKDDVSDSTKEEETNGKTSKRSRKNRKRGSVNSVTSQKQPAVKLHIGNLAYSTTPSDLYDHFSTRYGKDNILECHIPIERDTGRSRGFGFVTLPESIANEALQSREQHEIDGRLVKVAKSSSAGSNNSGKSITPANAHLSTDRCAKFFPVLIDHQPQLEAVVVVLLQTMATSQVSTEGPIAIATTATIENLRRTATTEAILTVMDEDGPTMNFEIVPTIGLMTTIAISTVIEVVVDGIGQYPLAVVAPDDAEHTRKDDPIVVTKNPIGRADASELGVAREAATATVVGAVIAAAEKKASADVAEAGAGHSVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAW5</accession>
    <name>B7GAW5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184263.1">
        <property type="nucleotide sequence ID" value="XM_002184227.1"/>
    </dbReference>
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    <dbReference type="STRING" id="556484.B7GAW5"/>
    <dbReference type="PaxDb" id="2850-Phatr49521"/>
    <dbReference type="GeneID" id="7195741"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49521"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="41771at2759"/>
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        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="438" mass="49774" checksum="28C10AC6DB96719F" modified="2009-02-10" version="1">MRARPRASRRGVEDALPLTVQQAQSNGSGSLTNSPSRKSVGGLSSRTFRSNKQHGNLLRARLLVSLSKHKGLSKWVGLILAVLGTIGWFRSSFGNHRDGSPRSITSSSSRSLHRLARRAAVRALSPSHKHFHEFDISSYALGGMFKYIGNGSYRQVFLAKLPTENVIFKEANWDNGHESGFHTDEYEFMRQDMVVGESFTSNPRFVDIYGFCALSMFSEFMPFGDAEVMAQTIFDRHNPPSIKEGGELVIFNNLTGTEKLEYALQMADAVSYLHNYPGGVIVHDDIQMPQFLLTADKRIKLNDFNRAEVMLFDEENNEYCKYRNNPGHGDWRSPEEYYDKPLDEKIDIYSLGNNFYALLTGMGPFYEEAHSDGVIKKVKAGMKPYIDQRFLERSFAEKKLAEIMVLCWEYDPVKRPDINTLVQVLREAVEENLRLQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB52</accession>
    <name>B7GB52_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184402.1">
        <property type="nucleotide sequence ID" value="XM_002184366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB52"/>
    <dbReference type="PaxDb" id="2850-Phatr49590"/>
    <dbReference type="GeneID" id="7198247"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49590"/>
    <dbReference type="HOGENOM" id="CLU_1301825_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB52"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="212" mass="23577" checksum="3ACB16DDCB790698" modified="2009-02-10" version="1">MNTDRETSSFQPVPFSVEASSQQSRTAGEDDPNSPRGSTSRSGGSWTILSSRASADIPLSVPQQFLPQFHSPASSALPIPDCDFDDWTEHSQPAVDVALSSWQEEAHWMSFRNAVNVFVQKRGRRRSPNSISYSQYLDSQPTTRDVSQHQHDTDSDVSSLGQQLLQYGLNRTEISTNESPSNQPETRIQQALAQAEADELEFAELIKQNAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBW8</accession>
    <name>B7GBW8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_30615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184598.1">
        <property type="nucleotide sequence ID" value="XM_002184562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBW8"/>
    <dbReference type="STRING" id="556484.B7GBW8"/>
    <dbReference type="PaxDb" id="2850-Phatr30615"/>
    <dbReference type="GeneID" id="7198363"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30615"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="InParanoid" id="B7GBW8"/>
    <dbReference type="OMA" id="FTQATMG"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="116" mass="12318" checksum="11A1D103C31B12EC" modified="2009-02-10" version="1">MGITKDVISAGDGTNFPKAGDKLTMHYHGTLASNGQKFDASRDRGRPFQFTIGIGQVIRGWDEGVMQMSLGETAMLHISSDYGYGRQGAGGVIPPNADLDFKVELLAINAKSQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC77</accession>
    <name>B7GC77_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184671.1">
        <property type="nucleotide sequence ID" value="XM_002184635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC77"/>
    <dbReference type="PaxDb" id="2850-Phatr49891"/>
    <dbReference type="GeneID" id="7198517"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49891"/>
    <dbReference type="HOGENOM" id="CLU_390034_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC77"/>
    <dbReference type="OrthoDB" id="46313at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="92146" checksum="B10CF0E7F1CFD525" modified="2009-02-10" version="1">MILRRTYRQLFFKYAFLLLSFGALYFQSRGLLGIWDENAHTWTNVPDPSSWLNENRNRGPYSIHSVATIEGRNSLTARHSSNEKYNAIESLLPTDQGFGACLIMKDDNHWLIEWIAYHYHVLPLKHLIVLRDPRSLTPSQHIFDRWNQTYLEIEEWQDSRVTPISVYERGTKKKKTDLQYHLTRQRFFYSKCLKHLKQEQTVQWVLLTDTDEFVRVNSLLYPLSASVLQQRGHVSAFLAQRKVQDPCLQMPRIQVSSIRASESSINDQGKIDSWKRAESIEGLNASDFLTYQWLVHNNQAMSAGKSTMYLPTLKTNDIPSLADSVHRIVSSVCPEHSESLLNSTRSYLSVMHYLGTYEQFSYRTDPRDYDAKDAERAQKQFENIKSTSVKSRVDTWYHRGRKPAASTLDVGMTHWLPGLVETVGLYEVKKLLENVGVLESIPVETSQHSKSKQQPEIDVEEEVFSACLLTKDDNHWLIEWLAYHYYVFKLRRLTVVRDPTSRTSIEAILDRWKDRMSISVWNDEQFVPSWILQKHKTRGISDTLLHRYRQQFFYSSCMKDFKQRDRSWLALVDTDEILRPNPYVLTAPIDLKVEGIGLTLLEEQQKKRAMRAEDGPLKCIHVPRLQIVSTEANASTVSSDIPLGLNGSDFLTTRWLYHNNREISMGNNLDGKSVFNLQWLDESAIPKRAANAHYIIPGVCPETSGDRLDHPDSWLLIHHYLGSLEQFVSRDDPRNSIEGRPKRDASLWRQTGQSPAADTFDDSLRSWLTGFVESVGYVDAKRLLAGVGQVEELSPMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC99</accession>
    <name>B7GC99_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lhcf17</name>
        <name evidence="11" type="ORF">PHATRDRAFT_56310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184763.1">
        <property type="nucleotide sequence ID" value="XM_002184727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC99"/>
    <dbReference type="PaxDb" id="2850-Phatr16322"/>
    <dbReference type="GeneID" id="7198609"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56310"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318705_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC99"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853226" evidence="10">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="206" mass="22183" checksum="2F02442FC1F0DC09" modified="2009-02-10" version="1">MMRLLTALLVSAASVAAFAPQTSVKKSSSTLNAVAPEKEIGVLPPIGFFDPLGFTTRGPYGSREENFRHYRGVEVKHGRIAMAATLGTLVQQNYRFEGFLSPSANLEFAEVPNGLAALDVVPLAGWVQMAVVIGAHEFLVKERPGRKPGDFGTGYFGVALDDQSAKQLRLLNVEVSNGRLAMLGILGMFASEIIHGEALFETKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCD4</accession>
    <name>B7GCD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184787.1">
        <property type="nucleotide sequence ID" value="XM_002184751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCD4"/>
    <dbReference type="PaxDb" id="2850-Phatr49937"/>
    <dbReference type="GeneID" id="7198541"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49937"/>
    <dbReference type="eggNOG" id="ENOG502STE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641698_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCD4"/>
    <dbReference type="OrthoDB" id="48834at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="323"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="323"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="428" mass="46646" checksum="0DF314B29B5AB4BD" modified="2009-02-10" version="1">MQPNYNIGGGDAAHWNGGHGDEKSAMSNGYNGSGGLASFQQQQQQASFQQHQANALGGYGAGAASQFPMWSQMPSGSDGYAGGGADPFHPYMPQQPTPDMMQQMSGLTNGGYGGGYPGQDMQQMMFQQMMNSQAFAAQQTGGYGGMPGSNPSMAAYYGLPTQNASSMAHAAASSSASAGLDRKSSRPKKNKDKPKRPLSAYNLFFKDERLRMLSAIPDKKVEDKEQTSDDDTKKEDDDNDDPKATNEKEDKIKAEKGKADTEKATDAKEDEDTSEDIKADTDKATDVKEDEGNKQDSVNEETDSKASLEKNEDKDSSKETKGKEEEKSGTAAKGEDESKNGKRKREPHGKISFEAMAKAIGASWKAIDPELLDTYKARAAVDMQRYKKEMEEFLIKQRQGLEESRDQLETSVDPMAKMRYFSTSNTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD74</accession>
    <name>B7GD74_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_41069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185003.1">
        <property type="nucleotide sequence ID" value="XM_002184967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD74"/>
    <dbReference type="PaxDb" id="2850-Phatr41069"/>
    <dbReference type="GeneID" id="7198952"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41069"/>
    <dbReference type="eggNOG" id="ENOG502S8SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971336_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD74"/>
    <dbReference type="OrthoDB" id="199943at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="135"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="34497" checksum="EB77F4B1BC2431FB" modified="2009-02-10" version="1">MRPIVGYATALTVCLLLYTIEGFTRTVFLQAKTASLYVQTRGLSQFIHSQRRALQRGHGLKPSQLNAERLSNAVESSRLKKELLALAKRTLRGFQASTKDRRRARSLIDQLAALNPTRDPAKSYYATQTQESNAIDSKDGSSSKLVGEASLSGKWTLVYTDAPDITALGTTNPWAKLGRIGQECEPPYIRNVIEWKRPGWATSLPFSGSEESRVLQRVVTKATASPDQPMVVNLDIVGLRINADAPTTLSNFAEAIQSQGLIAGFFQAAPVDLQGPLQAPFGKFEVLYLDEELRAVKTGQGYVAVNLRTGDEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDJ7</accession>
    <name>B7GDJ7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_23908</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185141.1">
        <property type="nucleotide sequence ID" value="XM_002185105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDJ7"/>
    <dbReference type="FunCoup" id="B7GDJ7">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDJ7"/>
    <dbReference type="PaxDb" id="2850-Phatr23908"/>
    <dbReference type="GeneID" id="7199120"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23908"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="B7GDJ7"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="33641" checksum="B45B93EF5DB772AF" modified="2009-02-10" version="1">MSLTNNNSHSLAKTLEPFVCGGSAATFASVIIHPIDLAKVRMQLYGQLNPGKPIPSFPSIIKSIVTRDGPLSVYKGVDAAIGRQMVYGTARIGLHRTFSDKLVELNDGKPISFLQKTLSGMLSGSIAVCIGTPFDIALVRLQSDGMAEPQDRRNYKNVFDALLRTSKEEGVGALYKGLLPNILRGMSMNVGMLACYDQAKEVVAALLNDPMTNGPSLPTRLGASATAGFTAALFSLPFDVMKSRLMAMKPNPLTGEMPYKGVVDCAVQMAKNEGPRSFFSGFSAYYGRCAPHAMIILLSIESITNLYRQTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE82</accession>
    <name>B7GE82_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_24120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185438.1">
        <property type="nucleotide sequence ID" value="XM_002185402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE82"/>
    <dbReference type="ESTHER" id="phatc-b7ge82">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr24120"/>
    <dbReference type="GeneID" id="7199274"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24120"/>
    <dbReference type="eggNOG" id="KOG2281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GE82"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="371"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="568" mass="63942" checksum="BDD30F67E3918C42" modified="2009-02-10" version="1" fragment="single">MDRYRGFWWHPDSCGILVARVDESSVPVYRIMHQEVEDGHAYEDHRYPFAGKENPTVRLAFVPIDSVSVAQSLTATEYLARVYWLPDGSAVAQWQNRTQTVTVWQRIPVLETPIRPRTLVMERTDVWINLHHMFHVLPEPVAPQQCGTSGRDPQIPPFPAPLPPGAFSFLLASERSGFQHLYLYTYCPGINGEQAVLLRTISAGEWIVESIVGVDMDRDVVFFTGTYDSVLERHLYALPLTYRDEVKANGMDSDGGSTVRPIRLTVDSGMHSIVMDEDCEIFADTSSDLDRPTSVKIYEVSKNILARLLANLPAPELLKFPTSDGSEMLHAALYRPDARIHGPGPYPLICAVYGGPHVQRVNRSWSQCADMRAQRLRSLGFCVVKCDNRGSSRRGLAFESAISRRLGRLEVLDQVAAVRQLAARGVADPNRVGIYGWSYGGYLSAMCLCRAPDVFHAAVAGAPVTSWDGYDTHYTERYMGLPSDNPAGYRESALFEHIPNMSGSLLMIHGLIDENVHFRHTARLINKLVASGKSYELCIFPDERHSPRRLRDRIYMEQRIGDFFVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3L5</accession>
    <name>B7S3L5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_bd1828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176158.1">
        <property type="nucleotide sequence ID" value="XM_002176122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3L5"/>
    <dbReference type="FunCoup" id="B7S3L5">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7S3L5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1828"/>
    <dbReference type="GeneID" id="7205064"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1828"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S3L5"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF75">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT 5 OF PYRUVATE DEHYDROGENASE COMPLEX, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002862894" description="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex" evidence="6">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="477" mass="49205" checksum="342A038DB2B5DEB3" modified="2009-02-10" version="1">MKFHTSAALWIAFATASSVDAFRVTSRPSVTLRPWRTALRAEGTKITMPALSSTMKEGRVVSWLKNEGDEIEAGEAIMVVESDKADMDVEAFEDGVLAKILVPEGAMAPVGEAVALMAENAADVASVIASLGAGSSASEPVLDAPAPTSGTYVSPVASTPATTAPASPATAPAAPQAAAPRPAGERVTASPLARKKAQELGVDLNTVTGTGPSGRVTASDIEAAASGTAPPRPSAVAHAAANGAPAVELPEGVVPMTGMQRAVSNNMVATLPTPEFRVTREIQMDAFDALYQKLKPNGITVSAMLAKAVALAIEKHPIINSSFSEEGGGSIVYKKDINIAMAVAIDGGLITPVLQYANERSVVELGENWKELVGKAKSGTLAPAEYNSGTFAISNMGMFGVTHFGAILPKGIGGILAIGATQEMIVPDQSAILGMKKVKKMSVTLTCDHRQIYGADAALFLKTLADMMENQLGKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4A6</accession>
    <name>B7S4A6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_bd1425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176419.1">
        <property type="nucleotide sequence ID" value="XM_002176383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4A6"/>
    <dbReference type="STRING" id="556484.B7S4A6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1425"/>
    <dbReference type="GeneID" id="7204920"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1425"/>
    <dbReference type="eggNOG" id="ENOG502RRCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052686_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4A6"/>
    <dbReference type="OMA" id="LTHFSMR"/>
    <dbReference type="OrthoDB" id="43820at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504:SF2">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40767" checksum="341DD12C7320C966" modified="2009-02-10" version="1">MQAETSTVSLTPHTAPSHQALTLVGRSWAGDGTSCFVPELHCLWDCGAVVTPRTPHAIFITHTHADHVQMLPYLLHRATVTDQPIPLYLPAAFVSRLRDYLHAHQHLVQSGGDDDDDNDTDYTDTDTKMSYSRPLYERCTLVPVQPGDELTVRIPARRDPLLVRVVACHHRIDCVGYSCWEQQTTLRPEYRGQDVAALRKQMAADALFRTTRRPLFCFLGDTTHRVWTQHAELLQQHHVIVVECTFLDNATVNKAVATRHMHWKELQPIVNAHPNVWFVLLHGSLRYSSLQRLRFFQPPDVCPHRNVHVLVRPEDVAREWQRERDKNANKTNVRSEEAEELAPPTCQCVRCQPSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4G5</accession>
    <name>B7S4G5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_bd1493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999287">
        <property type="protein sequence ID" value="EEC42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176455.1">
        <property type="nucleotide sequence ID" value="XM_002176419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4G5"/>
    <dbReference type="STRING" id="556484.B7S4G5"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1493"/>
    <dbReference type="GeneID" id="7204999"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1493"/>
    <dbReference type="eggNOG" id="ENOG502SEK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580758_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4G5"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="258"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="334" mass="36999" checksum="FD8E39B9A119525F" modified="2009-02-10" version="1" fragment="single">MVKMLEPTSIVVEHVEDDRKVFVSRVPLNFSQASIKRLIEGSVGADVVQEVVFTYDNDEQAIGGDSKSKHKGYAFCVMENVDSAAAAISLGIVKGGRTETSKKSHTLYLSAYKHEAKDEKEIPDICFLWIHKRCPYGENCKFVHHGNGGVLDQRAVSAFPKPRKCWDFKKGKCKMGDTCPFSHEGIEPISIKEKIDRPSSEKDCINWKTKGKCRKGETCPYRHSVSLREQAIAKLATNRPGESAFQTVAPGKRTSEPLSVRVFGLNYETKESDVRDFLAPCGTIMNVSFPCWNDSGRSKGYCEVLFQSPKAVAAATALDGSDLHGRWLSIQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0C3</accession>
    <name>A0T0C3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replicative DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="13"/>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="11"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874398.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0C3"/>
    <dbReference type="STRING" id="556484.A0T0C3"/>
    <dbReference type="GeneID" id="4524578"/>
    <dbReference type="InParanoid" id="A0T0C3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001761">
        <property type="entry name" value="Replicative DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="entry name" value="DNAb Helicase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30153:SF2">
        <property type="entry name" value="REPLICATIVE DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30153">
        <property type="entry name" value="REPLICATIVE DNA HELICASE DNAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="N-terminal domain of DnaB helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0934">Plastid</keyword>
    <keyword evidence="2 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="185"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABK20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="460" mass="53025" checksum="364566BAB802AFEB" modified="2007-01-09" version="1">MQQTPFNVDQLIIDKYLPHNFLAEKMILSCLLINSEAIEITLRKLPYEAFYFKNHQEIYKAVMILYKNKKCIDILTLLTFLQDNGLLQKIGGVKVLIELMSQIPNLVYLEEYISLVKDKFIRRSLIKLGYEVINSGYITNLPLEQILGDFENKLFNLTNEITSQKLFSSAELLNNIFFELKEKSLNPSLFGLPSGFYDLDSLTQGFQKSDLIIIAARPSMGKTALGLNIAINTIKNSRLPVLFLSLEMSKEQIMYRLLAMETNINQMRLRSGKLYQNDWIKLNKIIKIVSKLPFFIDDTSNLSIQDIRSKIKTILFEQNRIGLIIIDYLQLLQNSDNKSENRVQELSNITRSLKTIAREFNVPIIALSQLSRNVENRLDKKPILSDLRESGSIEQDADLVLMLYRNEYYNENKSLDKTKQLTELIIAKQRNGPVGTVKLKFDEKRTKFLNANDADVNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3C1</accession>
    <name>B5Y3C1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_36668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185624.1">
        <property type="nucleotide sequence ID" value="XM_002185588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3C1"/>
    <dbReference type="STRING" id="556484.B5Y3C1"/>
    <dbReference type="PaxDb" id="2850-Phatr36668"/>
    <dbReference type="GeneID" id="7204484"/>
    <dbReference type="KEGG" id="pti:PHATR_36668"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431182_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3C1"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="579" mass="63131" checksum="9A46180CA05335EC" modified="2008-11-25" version="1">MVDAKRQRNQQVLLESGLLSLAATVRASARPVPTRTHTGLTARKRNATHDGKFESARLQRKSNRIAGIASDGLYVQEERAGRFTLAGTHDTNNPSRIDSMDTANTTNHNNNHNQNDVKEHYRGRVNDGADLSLAQVVALAGPKWTDDDSLSHAQALFRRLQSADFAPPDDCALPDTPHAAHKEMDNTTTAIPCKVVTPGSTPTNTLHNTTDTTIPSHDHFVRQVQHMSVDSDHQVAKVVPDRIYGIATHPSPHQLIVCAGDKSGYVGIWNVDAYHPEKDTDKAVHVFKYHSGAAACLQWNSNGTSLLSASYDGTVRVLDVATASAQQVFATFDDDPVHAHRPGANTDTGYRFWTQYACWDASEQGLFVATSIGTALHVDLRTAPASKVTFHEQLAEKKINTLSLHRNGHTLLSAGLDCQLQTWDWRKLGDNRTSRHSKAPSPVASYHCGKSVNSAYFSPTGTYAVATTMAHKLDIFTNLERASGSNSKPTKSLRHDNLTGRWLTTFMAVWHPTLDVFGVGSMQKPRAVEIFDPSRTVPLVRAIQGDALTAVASRCAFHASTGRPVLVGGNSSGRVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y443</accession>
    <name>B5Y443_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATR_13470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185941.1">
        <property type="nucleotide sequence ID" value="XM_002185905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y443"/>
    <dbReference type="STRING" id="556484.B5Y443"/>
    <dbReference type="PaxDb" id="2850-Phatr13470"/>
    <dbReference type="GeneID" id="7204731"/>
    <dbReference type="KEGG" id="pti:PHATR_13470"/>
    <dbReference type="eggNOG" id="ENOG502S84E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499206_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y443"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACI65411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="194" mass="21461" checksum="72B6F31C86AA98F0" modified="2008-11-25" version="1" fragment="single">VIGSDESGSGCIAGPVVTASCCVRDNAADGLWIDGVDDSKSLSTKDRERIYEAIVQNPSRYLWSIQERSAAEIDEQSATNATLNCFQDSIEDVVSQLRAEYPHCQPYSIVDGHRSPKVDGCTSRPWKQGDAYVYTVALASILARVTRDRHMALAAVKYPLYDFDRNGGYPSRAHTEILHQHGYSPIHRQSCKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4D1</accession>
    <name>B5Y4D1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M11 gametolysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_33106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186270.1">
        <property type="nucleotide sequence ID" value="XM_002186234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4D1"/>
    <dbReference type="PaxDb" id="2850-Phatr33106"/>
    <dbReference type="GeneID" id="7204245"/>
    <dbReference type="KEGG" id="pti:PHATR_33106"/>
    <dbReference type="eggNOG" id="ENOG502SRDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417690_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4D1"/>
    <dbReference type="OrthoDB" id="48545at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008752">
        <property type="entry name" value="Peptidase_M11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05548">
        <property type="entry name" value="Peptidase_M11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841150" description="Peptidase M11 gametolysin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M11 gametolysin" evidence="3">
        <location>
            <begin position="182"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="657" mass="71500" checksum="27A075D3D2121C13" modified="2008-11-25" version="1">MKFLPACARILLLIWLTGTVMSVQSWLGSSAQESTDSIVCRITLSATLLALPTIGKPAVSTNTVACIPIVDNRETADLFSIDLPLHFWEQHAVAAANGTLLVSIEGASITRKGIVATAQATFQVLPELPNSSRHLSLDDDPNHYWTTGIKTIAVVRISTRDAEPTYSTADMEWGIFGDGLENDGVTMPTQYNACSFGKLRFIRSVYGVVDLKLDRTLGSFESVDSIFQSAQKQLVEEHNLDSITDLGDKILFCLPPGTGSWIAVAGVRHWRALFNDQWCLSLSALMHEVGHTVGLMHSNEAGQIYGDQTGYMGFGRLAVNTPRQCFNGHKNDVLGWYKDRVVAVDPKEDGGGARLYKIAAFVDYDKAASNEPVILDVGGQIFLQYNRAKGFNVGTEEKGNTLTITEYDGTDSSTNLGGLKVGEEFGEYNFQHSGHVLMIQVCETIIGDSNSPDAMIVSVGLDQSLCRNAQMASPQADIQGMPFPLTASPTVSPTVATNYPTMTPTLSPTSPPVLNPTRRPTTSPTHSSMFTETSHSTNSPTFRPSEDTAEAIRSIEGLPFTRTPTLAPSALPVAAPGLPFSDDEQAEPNEAITAPPSQRRPLRNYAPRVESFPSAAITQPPSQRRPLRNYAPRVESLPLKKEKTTESRMHDRLRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4N0</accession>
    <name>B5Y4N0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186039.1">
        <property type="nucleotide sequence ID" value="XM_002186003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4N0"/>
    <dbReference type="PaxDb" id="2850-Phatr33208"/>
    <dbReference type="GeneID" id="7204297"/>
    <dbReference type="KEGG" id="pti:PHATR_33208"/>
    <dbReference type="HOGENOM" id="CLU_1470950_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4N0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="184" mass="21346" checksum="6131A8A17BA36B82" modified="2008-11-25" version="1">MTPKEQLEDECGARHQYFENISQTIKPEMRVDFDWCSDSSVDEADMSEIMQSLESLPSFIERNESLDHKQWLWPSSSFQTADDREIESSEVSTASVDSESSAADDDEKAITLDNRGYTQENEIYDRFREALVEKGGKRGSSVRFDKDSIQVQTYEPPCTSCHSDLYYSCHQLQRMIDENRRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4X1</accession>
    <name>B5Y4X1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_43962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186369.1">
        <property type="nucleotide sequence ID" value="XM_002186333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4X1"/>
    <dbReference type="PaxDb" id="2850-Phatr43962"/>
    <dbReference type="GeneID" id="7204383"/>
    <dbReference type="KEGG" id="pti:PHATR_43962"/>
    <dbReference type="eggNOG" id="ENOG502SND9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1051551_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4X1"/>
    <dbReference type="OrthoDB" id="47367at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="302" mass="35164" checksum="DA62D91161E069A2" modified="2008-11-25" version="1">MDCHKRLSSTHLQKVVKFCRGRGNVLGEKFFHFRQMTMHYATLRWLKKKSNPIGWLCAQKRPFDGLMKTLGSYKSQDTPDYLIVVDDDTWVNIDQLVSSLRSMYPAELPYAIAGCMIRSRVHEHNFTIPYGGWGMIFSRPAIENLMKPLYCNTAPNNFEDEFVRLACWRLSESPIGEQPLFREGMSVAQLMHAYVNDQPYQQVDSWNSLGYCLHSDWVWGYFTNFYHISVHTNTPKFSSLLEDRLQGFNGSMIYAGRPTPETEELKRECRNQGDDMCTKNSNMCHYVTPQHMERLTLQLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y563</accession>
    <name>B5Y563_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hNpl4</name>
        <name evidence="3" type="ORF">PHATR_56433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186415.1">
        <property type="nucleotide sequence ID" value="XM_002186379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y563"/>
    <dbReference type="FunCoup" id="B5Y563">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y563"/>
    <dbReference type="PaxDb" id="2850-Phatr44044"/>
    <dbReference type="GeneID" id="7204000"/>
    <dbReference type="KEGG" id="pti:PHATR_56433"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052923_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y563"/>
    <dbReference type="OMA" id="DYTMSTA"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="473" mass="52517" checksum="5DF365F1F799D835" modified="2008-11-25" version="1">MLIRVRSNVGVWRVDGLDAETATVTDVLAGIARSRPHVVYERPLARDPACHETLSTTETLRAQGLDQNGAMIHCRVDPTTCADWTAPAAEMSPSTMTGNATVEPKEQGQHFRRVIDKDGGIKLVPTKDVPTQQDRGFRKGMLPLRDMKMSWTLNDFIALDSQFEFKIQRQEKATTSKVSLDVPSISNFQTYLQRFQFQRKRCGFLYGKFVKEDESDEKPTKVLVEAIYEPPQEINPDSAEGFTLEDDPQEEEVNQLAEWLGLQRVGWVFGHAPRQGYVLSAAETILAAEFQLEAAGGVEETPFCTVTVAPKLDGQVAVEAFQVSQQCMAMVAEEALQVDPDNPQLCKVNETFTAIQEGKASPTVETAFFLTVVPIVQHTSETFVADFPRANRDLDDTAPNKDALTRQLRQAGSNGWTLVDRLADFNLLIYLKSSFDFQSDFPKICAAIANRDIPLDDGYKLLIASLAGLDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5H6</accession>
    <name>B5Y5H6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_33511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186185.1">
        <property type="nucleotide sequence ID" value="XM_002186149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5H6"/>
    <dbReference type="PaxDb" id="2850-Phatr33511"/>
    <dbReference type="GeneID" id="7203895"/>
    <dbReference type="KEGG" id="pti:PHATR_33511"/>
    <dbReference type="eggNOG" id="ENOG502SJDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724552_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5H6"/>
    <dbReference type="OMA" id="HMDERHE"/>
    <dbReference type="OrthoDB" id="204385at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="389" mass="43725" checksum="F3BE3E684A65AC73" modified="2008-11-25" version="1">MKIASANGLQAQNQSKSQSSTEKPYATCSNPIFASLDVDGLKATICAGQVYQQRNFLSELQVSSLLQEVKELEDAGEFVRSGLSNTAERGNQQFGESDRSTCIVPWWMDFIHGNELPITNIVGPSLHHLRQTLAEIFDRPTLLDSSLAHECYFSTSGVGSFLPRHMDERHEELKGPKGWIQPSRRSFTWLIYLSDDNWTLEENGGALRAYPQQKVLRSHNLGSAHNGNLQIGWLQSKNGSQPVYMDSWCTIAGDSEPHCLLYKVYDEERVVLTKPWKTTAILQGISVSEFLQEWAIKDSNGIGKPVLFLHEQDAKQFNLLEDRRNWNSGKDPQGSFPFDVSPERALLLIFDSLLVPHQVEAVRKGRRVALAGWFHEATQPIPASLYVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP13</accession>
    <name>B7FP13_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_42642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177136.1">
        <property type="nucleotide sequence ID" value="XM_002177100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP13"/>
    <dbReference type="STRING" id="556484.B7FP13"/>
    <dbReference type="PaxDb" id="2850-Phatr42642"/>
    <dbReference type="GeneID" id="7196309"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42642"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396124_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP13"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="366"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="696" mass="77246" checksum="050C9477153C0A3E" modified="2009-02-10" version="1">MEEVLCTATSEIDSAESLRSKESASPMENSTTLLTKVEKGRLKKLVKRAKSVQANAESGICQAMDWEELMELRRKQSSASLIPENAFVLGPSVLWRSGKARERVEGTDVRAVLRRLIEQQPHKRGGDISSSENRTDSATDTLPNDTAETSRKRKHVSECRITQANVQDQNRFKLPQWVTLHNAAAARHVAVLEIHCHDVSRFLACQQAIRQCLRENESCLATESPTRWFTNNFPKSITDVLMYAPDPKPTCLPPNKVTSLQHLYNLLNDLVVKDDDWQREDYPALAVVNESTHTTVVLPSQDSSACEAASPSTSMERSPGTYDPNGLSCTSATKTDGLPPYVGTTVVKAAIPVVEAPSPFSSHRRGIFAMDCEMVVTSKNASELARITIVKVESVTEEGHVQTKVVWDQLVKPKHTITNYLTQFSGMTPALLKDVTFTLEDVQDYLLRNIQDGDIVIGHSLENDLRATRWVHRRIVDTALLFQPTHGRFKYSLRHLTAQLLQRQIQQADQSHCSEEDAIAALELAVRRAVQGSTFGVPDKTHRNQLSSMAKNETTVCIGPSSWLQTHVTSQPNAIHALACESIEDWNHKAVAAWLAGPKRRARMVWANWSVENDSATSILISTLSGLLTKRSLTNTVIMVALQPSYGVAAQLHQQRKVKSNPKATMGWSDVQEAGWMKASEDCQTGSVFWVGTKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPG1</accession>
    <name>B7FPG1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176708.1">
        <property type="nucleotide sequence ID" value="XM_002176672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPG1"/>
    <dbReference type="STRING" id="556484.B7FPG1"/>
    <dbReference type="PaxDb" id="2850-Phatr42762"/>
    <dbReference type="GeneID" id="7196138"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42762"/>
    <dbReference type="eggNOG" id="ENOG502SZKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387578_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPG1"/>
    <dbReference type="OrthoDB" id="45117at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="565"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="713" mass="78877" checksum="024404EB77D0EB14" modified="2009-02-10" version="1">MTSSRPQASISEVSDDDSNHGDLSDVEVSHEEHVRTLTNRGSYKSIHKSSTSRKLIRFHLMPRVRSKKSPDRSSIASDNATVEGVRSVVSQYTQASHDTVNVSNRTKAGRESRNHPHDKKNSKTRWSKLKRLVGVKTAPDDPGAPRLSSKSTDSAERVNTDDPIANRRRVRSADDAVTYSRRPRSASVAVTSNAIETTTPAQAFEDQSICGRLDGLDILALGGAGLITLPADTALPADWTFPTYSVTGQSLYQTAPRIVAEMLWTSAGRSAPEIILEGFIPGGEDRWSVRVEQRPTDASSFASSSTVYRSQSLPGLQPADTDEFEASEDGSVRWPSYKLWDSLWGSEPQPTNMTNLDKVPKDDDDPLLNLISDCSIPIDVDEDTFVIANRAHLVVIQEIAAGPLAKGQFESALAIFARLLKGLNLIEDQNLRFLKGTVLHNIGIVEMWRGQYERALENFTLAVKERSRYLPKRHPDLVVSIVRQSVALVALGRFDEALVALEKALDMVPPVADLVRAKILNNIGVVRFLQRDLTAALPSFTTALEILRRWLDGPIRRESIVFDAATTLSNIGKLYLERQDYDLAYFVYEEALLLQTTVFRKDHDIVLNGLTNLALAKVKTRHVQKAVQILQGCLRSQNSRFGPQSASAVETTGLIGHLYASEAQYEEALQCWKTVKKWQKTQLPANHAAAIQTRAAIDKAEHTIGQTSNSGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPG7</accession>
    <name>B7FPG7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177207.1">
        <property type="nucleotide sequence ID" value="XM_002177171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPG7"/>
    <dbReference type="STRING" id="556484.B7FPG7"/>
    <dbReference type="PaxDb" id="2850-Phatr9078"/>
    <dbReference type="GeneID" id="7196392"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42765"/>
    <dbReference type="eggNOG" id="ENOG502RZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112237_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPG7"/>
    <dbReference type="OMA" id="HYTSYGY"/>
    <dbReference type="OrthoDB" id="419533at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010206">
        <property type="term" value="P:photosystem II repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.810">
        <property type="entry name" value="Photosystem II Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01481">
        <property type="entry name" value="PSII_Psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025585">
        <property type="entry name" value="PSII_Psb27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038450">
        <property type="entry name" value="PSII_Psb27_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041:SF1">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13326">
        <property type="entry name" value="PSII_Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855151" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="178" mass="20069" checksum="9298CA657EE232F5" modified="2009-02-10" version="1">MMKTSLFLIAAVTTCASAFTPMQMPDSSSVTARRNFLQTASAAVIATTLPGAALAEIVVPPQTVDYEFPTDWGLTFKYEEDAVKVRQHMVVATGMAKGSEKMEEFGKNMKKEMVDFVSYYRRFPKVAGKPSFSTLYTSINVLAGHYTSYGFKYPLPEKRRKRLYQEYAEIEKSLKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ31</accession>
    <name>B7FQ31_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_9267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177322.1">
        <property type="nucleotide sequence ID" value="XM_002177286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ31"/>
    <dbReference type="STRING" id="556484.B7FQ31"/>
    <dbReference type="PaxDb" id="2850-Phatr9267"/>
    <dbReference type="GeneID" id="7196771"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9267"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673484_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ31"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="137" mass="14575" checksum="02BCD25126D90D91" modified="2009-02-10" version="1" fragment="single">ATSQAEQQITVSQLIPPKLCKRGATTDDLLEISYRGSVVETGQVFDGSAIKIDGGGIPGRGDDVSLYFVLGKQPFGQFPPGWDVGMVGQCVGERRRLIIPPALAYGSKGVPRRGIPPDATLQYDITLVSLNGFSTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQG0</accession>
    <name>B7FQG0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like DNA-binding domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_32183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177397.1">
        <property type="nucleotide sequence ID" value="XM_002177361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQG0"/>
    <dbReference type="SMR" id="B7FQG0"/>
    <dbReference type="STRING" id="556484.B7FQG0"/>
    <dbReference type="PaxDb" id="2850-Phatr32183"/>
    <dbReference type="GeneID" id="7196243"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32183"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1130909_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQG0"/>
    <dbReference type="OrthoDB" id="47994at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF274">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28242" checksum="E6C0806ABCAF4F4A" modified="2009-02-10" version="1">MDSFNKKIRDTKHKDIRGPETLWPDRSKATVLSLSIGGNQDKILSTPDYILTSPILFDSKTDGVAGRIYEDPKPISLRRTPKRWTEEEDAALLKLIETGGLREAAERGLPEVWIELADLLNNGRTNKQCRDRFQNHLRTGIKKGNWTKEEIKLIEDMYKSFGSKWSSIAQILTHRTENDVKNKWYAMKRVEERKTHYIEEFKSQRASCRTSAPAIKRRYESSRAAQMTHPRAGSNGACFNEASTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQH9</accession>
    <name>B7FQH9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="2 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_32202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176874.1">
        <property type="nucleotide sequence ID" value="XM_002176838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQH9"/>
    <dbReference type="STRING" id="556484.B7FQH9"/>
    <dbReference type="PaxDb" id="2850-Phatr32202"/>
    <dbReference type="GeneID" id="7196856"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32202"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_2_1"/>
    <dbReference type="InParanoid" id="B7FQH9"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000024">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF15">
        <property type="entry name" value="LYSINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="162"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="485" mass="54801" checksum="FACD20C0AD752F1E" modified="2009-02-10" version="1">MREVGVDPFEYTFATTHTSADLNKLYEHKLENGEEDESANVSVAGRIMTRRVFGKLAFFTMQDEMGMIQLQFDKGRLGDTFKNLKDWTDGSDIIGVRGTIRRTDKGELTVFATEWKMLTKSILPLPDKYHGLQDVTKRYRSRHLDMISNPGVRETFRKRALITSKLRRMLDDKGFLEIETPTLHTQSGGAEAKPFETYHNSMDMQLTLRIATELHLKRLIVGGFDRVYEVGRIFRNEGISTRHNPEFTSVELYQAYADYDDMMNLTEELVCTIAEEVCGSLSIPYGEHMVSLERPWRRVTMHDIVKEEMPDFDFSALDSQLPESLNTAKAAAIAAGVPNVQGLNTIGYVLNACFEELCEPKLIQPTFVIDYPVDVSPLAKRHRNKPGLTERFELFAVGREHANAFSELTDPIDQRERFEAQAAKKAAGDEEACDVDEDFLQALEQGMPPTGGLGIGIDRLVMLLTNSPSIRDVIAFPLLRPDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQI6</accession>
    <name>B7FQI6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177408.1">
        <property type="nucleotide sequence ID" value="XM_002177372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQI6"/>
    <dbReference type="PaxDb" id="2850-Phatr43069"/>
    <dbReference type="GeneID" id="7196710"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43069"/>
    <dbReference type="eggNOG" id="ENOG502QXP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1087616_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQI6"/>
    <dbReference type="OrthoDB" id="195110at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855192" evidence="1">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="350" mass="39523" checksum="A41A42B690208E9D" modified="2009-02-10" version="1">MAALPNARRGFSILSLIIFLVAHQGHGFQKASIKRLHHLAVESPFRTVRFADSVPDRVHAQKSSLPSWSATRSKRTLAMPLIIRQATSASDDEPMASLRAGIQKQLLRPFRKAKKVVKSMFGRSSEDFNKTVETLKNESTRKSEAVETDVVPKAQAVAMEMAKVVKEMASSIQIGQRSAVAAPSVDFSGHWNIEVTDEFKEHYDRYLRMLGQPSLVRSIALSIVALTTEEIIQKKQGRDLTIRGRNVRGVWERTMRSSCADEKIRLPVVTADGEEAEVEAWWEKNGSMHVSWMRGVQKYGGGDFESKRYIDDYGQALVCESTFHPSDATREKVQIKWRFRKGDGKEWNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQW0</accession>
    <name>B7FQW0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_9612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177475.1">
        <property type="nucleotide sequence ID" value="XM_002177439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQW0"/>
    <dbReference type="STRING" id="556484.B7FQW0"/>
    <dbReference type="PaxDb" id="2850-Phatr9612"/>
    <dbReference type="GeneID" id="7196325"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9612"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048814_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQW0"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF45">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="287" mass="31908" checksum="902FB7401BECAFC1" modified="2009-02-10" version="1" fragment="single">MEETFPERFTFHPTEWNKFPDGTDQIEIGGFHPQNLISGEHVLFLASFENNDVTLSQFQVMICLLQSFVESLTIVLPYSPVGTMERVVREGQVATAATYAHMFSSLPNCGKPTRLMVYDLHTLQNRFYLHGNAVASLQTAIPLLKKRLKNSEVNCVAFPDDGAAKRFSSLFLEMDVEVIVCGKTRGEGDVRSVVIQDGNAEGKHIVIVDDLVQTGGTLYESGKVLKEAGALSVNAFVTHGVFPNESWKRFNKGGDRACFDKFWVTNSIPTITKQLPIEDGVFEVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR78</accession>
    <name>B7FR78_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176994.1">
        <property type="nucleotide sequence ID" value="XM_002176958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR78"/>
    <dbReference type="PaxDb" id="2850-Phatr32455"/>
    <dbReference type="GeneID" id="7196611"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32455"/>
    <dbReference type="HOGENOM" id="CLU_000850_0_1_1"/>
    <dbReference type="InParanoid" id="B7FR78"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="799"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124443" checksum="F65C71EA9F2B9DF4" modified="2009-02-10" version="1">MVPATRQMTSAAVYAHLLDNVLLLPQGHPIRLSFEQQGYESADDLLCIFENELESLGYTPSVLPDGLENPPTIPLLMAHRQIIRHFLRWQASLERQKGTPLKNSELVALNNEDFVLYRRSALGQVSTATAPVNASPTVQSPIGKTRSAVEDFKRGIKRDKTHYPVLKDDRYWDNFYRSFVVTAVTHNVDKVLDPTYIPTDPLEKSLFEEQNKFVYSALEHTLQTDMGKNIVREHSFDFNAQEVFRKVVKHYTESASAKISSSTTLGYLTTAKYGSSWTGTAEGFILHWKNHLRIYNDTVPAGEQLPQQLCLSLLENAVHDVPELRQVKITATLDLAKGGNPISYGGYLSLLLASASLYDNGNNLSNSRSGKNKRNIYANELEYNPMDFESKPDVDYDIDVSPTAIYEANAHARNSSFRNRSPATNRERPYIPREMWNLLSDDAKAILQGLIAPGKQAPLNNSSPHQSLQANTHDTIGAEQITTDTFHDCAPETELLAHLTERVSHMSDGDIRKVLAASRDGPAYDEPTPLQSNVLQYQVSRHNVIETTAALVDRGANGGLAGSDVMVLHKTGRSATITGINDHTLSDLDIVTAAGYTESQNGPIILIMNQYAHLGQGKTIHSSAQLEHYRNHVEDRSRTVGGNQRIVTLDDYIIPLHIRQGLAYMDMRRPTDKELATLPHVVLTSDVDWDPSVLDHEIDLATSWYDDKYDLPQSPYVEPRFDHTGKYLHCHISLCNHRDDVVDRVLYCQQHLVTKNVQDYEALRPCFGWVSAETVRKTIMATTQHAREVYNAPLRKHFKSRFPALNVHRRNEPVATDTIWSDTPAVDNGAKFAQLFVGRRSLVTDAYPMKTDKEFVNTLEDHIRYRGAMDKLISDRAQVEISKKVTDITRAYNIDQWQSEPNHQHQNFAERRIATIEANTNNILNLSGAPDSAWLLCVTYVCYVFNHLAHESLDNRTPLEVLTGSTPDISVLLQFHFWEPVYYKLENATFPSGGTEQQGRFVGIADSVGDALTYKILTHTTNRILHRSSVRSATIPGQTNLRLTPQDGESGPKPINFIKSRRTENKNSYAIKELPGFTPDDLIGRTNHAENIGPRQALGCKVPCRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRK8</accession>
    <name>B7FRK8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_24362</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176561.1">
        <property type="nucleotide sequence ID" value="XM_002176525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRK8"/>
    <dbReference type="STRING" id="556484.B7FRK8"/>
    <dbReference type="PaxDb" id="2850-Phatr24362"/>
    <dbReference type="GeneID" id="7196072"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24362"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_2_1"/>
    <dbReference type="InParanoid" id="B7FRK8"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC51024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="328" mass="36950" checksum="FED8212B9C680AE6" modified="2009-02-10" version="1" fragment="single">MDDEKSGSAVNDEHVEFDRYRHIQYFAYCVRQLPGSYSKLDTNRLTLAHFGVHALDMLGVWEDEAMQTSLGLEKKAIIDWIYAMQVPAKKEHPSQAGFKGGSFLGGSFEDTADQPWQYNHGHIAMNYTALATLRTLGDDWSRLDRKGILEALKGLQLTDGSFASISVGSEHDMRFLYCACCISHMLNDWSCIDIDKAISYIRSCRGFDGAIALLPGQESHGGSTFCAVASLVLMKAVDKVIDREWRRDLLRWCVNRQVCGMQGRPNKNEDTCYSYWIGGTLRLLDNDQLLDHTALQSFVMNCQTQMGGFSKLIGAYPDMLHAYYSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRT4</accession>
    <name>B7FRT4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177857.1">
        <property type="nucleotide sequence ID" value="XM_002177821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRT4"/>
    <dbReference type="PaxDb" id="2850-Phatr43304"/>
    <dbReference type="GeneID" id="7197369"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43304"/>
    <dbReference type="eggNOG" id="ENOG502T0I0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1463980_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRT4"/>
    <dbReference type="OMA" id="ECTIVAR"/>
    <dbReference type="OrthoDB" id="203741at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="20335" checksum="C111690E894B40C8" modified="2009-02-10" version="1">MVWGASFGRLARQGIPRRGLVVGVGASVTAASSWLISGTPVRLEEAATTSIAVANPDACDFDVYLETPTADDLPTLLREFQAGKEVWPWIWTQPNVDGPHDVYVLPEHAMDESSSLTAIQTFRINNPGRNVMLVIPDPAVLDSVPKELLDHCGVVQSNIALLNHRHKILMLEDERVVCFDRLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRU3</accession>
    <name>B7FRU3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177861.1">
        <property type="nucleotide sequence ID" value="XM_002177825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRU3"/>
    <dbReference type="STRING" id="556484.B7FRU3"/>
    <dbReference type="PaxDb" id="2850-Phatr43312"/>
    <dbReference type="GeneID" id="7197376"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43312"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025773_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRU3"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="354"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="627" mass="69257" checksum="1E43882EF1EAAFAE" modified="2009-02-10" version="1">MTITPHHPPQSNASTIPVATSADAIGLRESLDEYPSDWSRHNPFHDGEIQLQKLAGTHRSVMSFAPKFIRPFLPEQHQEFYRAQSFLVAASRDADGNMWSTLLVASEGPNQSRCPGDFANLVDSPDPVTLHIRTQPVQGDALFGQIQVDSDLGLLGIEFASKRRNRVNGRILYSTPNDGMVLRVDQSFGNCPQYIKPRKEWWWNAEKKETEGASPTFSSSTKPSHLSELHIKTIQGATTIFLATGYRGQGKDTRFGNDASHRGGPPGFLLVRDKHTIVLPDFAGNNFFNSLGNLVMDSRMGLTIPDFESGGMLQLSGRAQIYPGALRLTMFLIEQVNVVPAGTFAIRWSIPSKGESRLLEVVSIVQESVDVKSFHLAAPATVSPNDDDKTSNHKLWGFKAGQHLPIELQTKDGEILRTYSLSGSPSLSSNTYRISVKREPLGKASNHLHDYVQVGDLVQVSRPAGDFTWRASELPVAGEVGENSGAKTRTLVLLSSGVGITPILSMLYQYVAQSKDLQAPRPALWLHGARDGAHHPFREEVSKLVQHAQLRAHLPLQTHVVYSRPSPKDAGLYDSIGRIRFALLQNIVVEWKDAEYFMCGSSSMMTDMEESLLKAGVRASDIHFETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSP4</accession>
    <name>B7FSP4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lhcr3</name>
        <name evidence="11" type="ORF">PHATRDRAFT_50725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178019.1">
        <property type="nucleotide sequence ID" value="XM_002177983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSP4"/>
    <dbReference type="STRING" id="556484.B7FSP4"/>
    <dbReference type="PaxDb" id="2850-Phatr9799"/>
    <dbReference type="GeneID" id="7197307"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50725"/>
    <dbReference type="eggNOG" id="ENOG502S5BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_3_2_1"/>
    <dbReference type="InParanoid" id="B7FSP4"/>
    <dbReference type="OMA" id="EQEIVHC"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855386" evidence="10">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="21107" checksum="F859DC739252A08D" modified="2009-02-10" version="1">MMRSTILAALLASAAAFAPASMQSQRAGSVSLNAEEMSKSIPFLVKPDKLDGSMAGDMGFDPMRLSDIQTDLKYARWSEIKHGRICMLAIVGILVQQAGIHLPGEQFTNTDIFGAVDSVGFGANMQIFAGIGAVEIATFNKHYGEGEPGDLGFDGGQLKGASADKIALRKEQEIVHCRLAMIAFLGAMGQTLLFGQALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT64</accession>
    <name>B7FT64_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell growth-regulating nucleolar protein-like winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177786.1">
        <property type="nucleotide sequence ID" value="XM_002177750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT64"/>
    <dbReference type="STRING" id="556484.B7FT64"/>
    <dbReference type="PaxDb" id="2850-Phatr43703"/>
    <dbReference type="GeneID" id="7197002"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43703"/>
    <dbReference type="eggNOG" id="KOG2186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057137_1_1_1"/>
    <dbReference type="InParanoid" id="B7FT64"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell growth-regulating nucleolar protein-like winged helix" evidence="3">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="192" mass="21084" checksum="F3AAFBCB9324EB1F" modified="2009-02-10" version="1">MNLIVSSVETAPGPLKHHLQVISGLDNVPRKEKQFRNFASNSLNLKGKQGEASVGEIWKYLKGLREEQQKAKQQKDEAIAAAKLKNAEATSTKELDELPNDGRHVDAVSACGLNDISPPNPKIVKKAIKKVLKKASGHKLSLKRLRKEIQLHLGASKSDKKRLKVLVQQTLESSTAKGIFLVSGDNVQLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT97</accession>
    <name>B7FT97_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177803.1">
        <property type="nucleotide sequence ID" value="XM_002177767.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FT97"/>
    <dbReference type="PaxDb" id="2850-Phatr43732"/>
    <dbReference type="GeneID" id="7197258"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43732"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248544_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT97"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="492"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1483"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1504" mass="166455" checksum="CD1C3819BB82CD28" modified="2009-02-10" version="1">MAEDSSADALNPVGDLPTEEPESEEATPEATLLNNLMILAPRQRNPSAGTAAAGLALPPLRAEEPVQSLRGALTEVVGYAHLTSFRFELAPDGAPQFEGVPQPSPPNTLVSPFTGPNAVVSIPSQLQSLNEDPQIQDRTEEKHADVLDEFGDLTPLLSRGLTDGSAFAMVLERYDAAGIKDHVQRLNFLMDGNVPSVVSLDNEKVAQVDEEVLDEKSTDGPKVPPLPELPTFPNDKSIVIDGTNLQDFYYMACGEDLNLYHGKAESSALKTKKKKKKAVVNGSRKTQTPEPVVIVSEVSPEALVKEKITRLNELEDICRVPCTIRYSGFHPPPTSRRWIGDLAYLEVTPPEGKTLHITAIPMGFYLNRSKSESGGRETFDPSPAVNSCFAHALLDCVLQASPSLSEAWRLALEASAERSEILAALNNKGTFTSLFRVAIRGDFQGFQSASTAHMATQALDSMLHKPSWLISLPRVFHNETSWNRNQLHSYSPTRSDHELANSFGVDIRSGTIRDWNEELQLARELPTEDVNERIERARLIHKVMTEFGEASLLGVKAIADGQISPMNPNEPTRSQVYLHNNIFFSRAIDAGPETFKLAKGDRAAKKSANRDIQCVGTFHRMEQNDLYTLATVLIDFLGTRYVCQSILPGILIGEKSHTLLYGAVESGAPLKWNEDFHKLMEDKLCDTMMIATRPILKNPLTEERQNEIKSQRKPNSSFADPENQDDADTDLNAVMQSCIPVEAKGILGSDQRKYVLDFGRLTPRDANWVPEKKGGTGKWEAAKTENGNKRHSAIPLDIKDDEWTMCVLRPELVSRYTQVSMGKYLQDKKNTEAERSAVDNPASENKPTSKDTMPTEGDEITSKEDNIDASEGSQVDKVNFPAAKDEDQLNEQNLSEEDLKYLKSLRLNVNVFLDDVRSFAENDSEAAELIQQDEGRAREVAVFLWEVILPKITLAIKESSVHQVPLDGFSLTEFLHRHGVNCRYMGRLAVLAKKQEEKDEQSDIELKEGRLSVIERRKMPKCWLELLECEMVARAAKHVLDRYLTENGGVAAAQPAQTIASFLCALVSESEETAAQTETRAMQCPADQPDEDDYTEMTMNDVGGNGNAVPSPVRGRHEVWHDIEMEIGRRFRYSLSLFNTGKPNGRALHIPLLRRVCQRTGVRLVAKRYDTGGKCLCSSGNVIGGRLAVSYPISPLDIVHVLPLMKHAAAYNEGFAACSIAQTVTIPALHISLPDARTALERAHVQMGSRALSRALELAQEASNLYQRVTDSAVHPGVIESIDLMSTVFLEAGDPHLAAESAAKALGLAVHNGGFDTPNVFNAHMSLFQMLYASRQMDLGLKHLRAAIYLLEVMAGPNHIELFSAYHKLGTVYSHSDYDGAYLETALECFKEVMARNGCDRLMDGITAKNHAKILAGLGNYKDAIVEEKRAHRTLFTFLGKDHAWTKDCDKELQMYTKLAVEHGNKKAETDKKNEEAARADALAADLIAQENRSKKNKKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTG1</accession>
    <name>B7FTG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_33075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178146.1">
        <property type="nucleotide sequence ID" value="XM_002178110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTG1"/>
    <dbReference type="PaxDb" id="2850-Phatr33075"/>
    <dbReference type="GeneID" id="7197055"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33075"/>
    <dbReference type="eggNOG" id="ENOG502S790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1117566_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTG1"/>
    <dbReference type="OMA" id="RHGARNQ"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28314" checksum="97C3C136B4AAAF2A" modified="2009-02-10" version="1">MEHQETEQSPERGPKPQGRNPNRKRHGARNQHKMKSFVRWLRQTFPDSFSPNEVPDNDIASHILDIAGGKGELAARLCMCDSQKVVLVDPRPADVVACFETVVLPRLPKKWQARLEARENSHAFIQETIRRRFRQITKALDASSLDTCDDLRNAIKNSSLLVGMHADGATEAIVDVALQNDKPFVVVPCCVFPNLFQTRLVHELETDRMVPVRSHSQFCKYLLAKDPRLQQFKLPFEGRNTAIFYTGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTV6</accession>
    <name>B7FTV6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_26029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178487.1">
        <property type="nucleotide sequence ID" value="XM_002178451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTV6"/>
    <dbReference type="STRING" id="556484.B7FTV6"/>
    <dbReference type="PaxDb" id="2850-Phatr26029"/>
    <dbReference type="GeneID" id="7198046"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26029"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_3_0_1"/>
    <dbReference type="InParanoid" id="B7FTV6"/>
    <dbReference type="OMA" id="TFWAWNL"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="478" mass="51515" checksum="947F9A3AA206C026" modified="2009-02-10" version="1">MSDIDDKPTPVESGEPSEWKKYSSYHIKTDPDQDDKASEIRLCSFARPHMRAFHCAWWCFFIAFFIWFAIAPLLSEIRDDIGITKQDVWTSSIVGVGGTILMRFVMGPMCDKYGARVLFMLILCFASIPTACTGFVNSATGLAILRLFIGVAGATFVPCQYWSSRMFTKEVVGTANALCGGWGNLGGGVTQLVMGSALFPLFKVFFDGDSEKAWRTVCVVPAIVAMASGIMVYRISDDAPKGNYDEMKKHGTMPEVSAAASFRSGALNLNTWVLFIQYACCFGVELTMNNAAALYFKDEFGQSTESAAAIASIFGWMNLFARGLGGFASDKANAKMGMRGRIWVQTIFLALEGALVLVFAQTGSLGAAIAVMVFFSLNVQAAEGATYGIVPYVDPASTGSISGIVGAGGNTGAVCFGLGFRQLSYEKAFNIMGYSILASALMSVFINIKGHAGLFWGKDDVVQKATLTVPAQEEEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTV8</accession>
    <name>B7FTV8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_26035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178488.1">
        <property type="nucleotide sequence ID" value="XM_002178452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTV8"/>
    <dbReference type="STRING" id="556484.B7FTV8"/>
    <dbReference type="PaxDb" id="2850-Phatr26035"/>
    <dbReference type="GeneID" id="7198047"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26035"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553810_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTV8"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29815" checksum="336D48DE2EAFA1F5" modified="2009-02-10" version="1" fragment="single">MTNTETMKNPKLIPINGKVHKKVDSDLLGKAVAALVTHHQKKVDESEKLSLMGNDTIVQVQIGLELAPVRPSPKPIRVMIPHPIFQVGQENSDDDSLEEPEICLIVKEESKLWVQDMIRTHSEHMKHVKKVLGLESLRKKHAQFSQRRELLSKYNVFMADDRILPMLTKALGKEFFKAKKLPIPVRLTRKEALPFAIRNALNATYMSLSEGTCITVKAGSTAMSSSKLVQNIEAITENAVANLPRKWANIRSISIKTPNSVALPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTX0</accession>
    <name>B7FTX0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_26057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178496.1">
        <property type="nucleotide sequence ID" value="XM_002178460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTX0"/>
    <dbReference type="FunCoup" id="B7FTX0">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTX0"/>
    <dbReference type="PaxDb" id="2850-Phatr26057"/>
    <dbReference type="GeneID" id="7197850"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26057"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="InParanoid" id="B7FTX0"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="66"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="386" mass="41857" checksum="71FB0C9AF4935B0B" modified="2009-02-10" version="1">MAVSTAKDGPCQAESIQNLPLPPPTYTIRDPEGRTIVLGIEGSANKVGVGVLQYSPSTQSYTILSNPRKTYVAPTGHGFLPKETAWHHQAHVVALVRAALNEAFPGEQSPELRISAVCFTKGPGMGAPLQSCAIAARCLALLWDVPLVGVNHCVGHIEMGRIACGTSNPVVLYVSGGNTQVIAYSDQRYRIFGETIDIAIGNCLDRFARTVGLSNDPSPGYNIEQEAKATDASFIDLPYTVKGMDVSFSGILTHVEQVAKTKLKAGEVTVADMCYSLQETLFAMLVEITERAMAHTGQNEVLIVGGVGCNLRLQDMMATMVSERGGSLCAMDHRYCIDNGAMIAQAGIFSLQYGEKTSLEDSWCTQRFRTDQVKTLWRAPRKWQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU63</accession>
    <name>B7FU63_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_33896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178543.1">
        <property type="nucleotide sequence ID" value="XM_002178507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU63"/>
    <dbReference type="STRING" id="556484.B7FU63"/>
    <dbReference type="PaxDb" id="2850-Phatr33896"/>
    <dbReference type="GeneID" id="7197692"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33896"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349006_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU63"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15504">
        <property type="entry name" value="PHD_PRHA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045876">
        <property type="entry name" value="PRHA-like_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="623"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="803"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="866" mass="96784" checksum="A50F67845B006540" modified="2009-02-10" version="1">MRQPSSSHNFDLSDTSAYPVRSAFPERFSKNHVGPFIVSEQGSTSNYRKAPAFYICEKMPKIAPKRQSKDLNCADDASSAGSLDVGACCLCHCALDYSDRAAFFRDDRHEDYHEDSDQEEYFFRKSDPYLPNTLYDPSNALVYCDSCDRMYHQKCHFVPLTVVPRGKWDCLVCQTQREKAKISLKKKKPATGNDHSKRKTPATSQDHAIPRLSSSCFQSPPNPGVREEEVAWESACRDVKAALWKAELHNRVPLQVNSQLANVRLAETALETLTSTAKNRSHFAQNSQELAQCMVRLYGSRRKLRHVLLNLQDLIRGDQEMRWNMLLRFCRDDASPEFVARVAFPFGMSHSRRVDPRTPEMTLNAEEHASNTVPAEISLTINSETQANSEPAQSITDQSKPIAKHDGDSGISLDNLRCCVCHQSEATDENDMIMCDGCGCYRAYHMRCLQPHVKPEEVENEEDDWFCPLCSTLADMMLLIQTNHMGDEWEQRRYAAELDGVKNGDDDSLKSWNAVEEVFPEVEVNYAAACDLKDGKRTTAASKLLGRILGLEEQEIDTDIDDDEEDEDDGHFDLESFQEKRHQARVELSGDKEDASEGSSQATLEEMSSVELNIGKDELAALSEVSEDEEESEQEVQRRSVRLRKSGNTSSANASVSDPGKLDESNILNGKRGRKSVDYQKLNDAIFGELSDGEIAKIDDTDDFLVATSRNQNDSSDSGDANDDSTGSSHVGEADELSLDDENEDSESENTENGIKDRRDDRREDDHLTVRSSRVNRPSTVRQLQSALAGEDGCTSVILSRSENVKKRKLKETAIPESQTNAQGAGAETASSDEASRSRKNRRGKFAKAALTMVSKLVQVAPSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU75</accession>
    <name>B7FU75_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178270.1">
        <property type="nucleotide sequence ID" value="XM_002178234.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FU75"/>
    <dbReference type="PaxDb" id="2850-Phatr44465"/>
    <dbReference type="GeneID" id="7197751"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44465"/>
    <dbReference type="eggNOG" id="ENOG502SEEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225275_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU75"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146196" checksum="1172AF65CD1DD335" modified="2009-02-10" version="1">MKGVRGIFRGSKSNRESDTALPSASSQQGEPLGSDLIVGVAPPSTARGEATALGSPQASEFRTYRTPDRAFSADRPSYKEGTPKIREAIAENYDDDGRESESDSERVGASAADVNDDRNANLTQSTIKSKHIATSAGTRRLQRIMNKPSTASAASENTGSSSKDPKRSVSAIAKERVGNVRNVEEVAKFAARVVLPPFRVDAASIGGSLLETYPTSMQQECLLCMSAQFESTGGEGIAMSALQYPANYTQHKRSLGLLGMGTKGRHKLRFIVIARSTNRPFLSKHKHSDLNETPRSKDGHANASEGTQDYDAMFGADDVDQESINRNDTSMTEEVSSPESNEVVSPAAEAQNSSAEDEVSSFPVLVCLTLNADGTAPDIRKLVPLDQLTTVQDLHASVVQLAFVNGDTVRLDFSETMGDGNMGNSPTSMEDKTVEATMDKERFIWSLLQIHAMLCVSVVDRLASATNKTQKILPPLNVRNMDRAELQYVATVNGFLRNSRILCAMLERQRGLMELEGTEEAKVALGEMEVIAYDLMMGNFSSRVELFHSEGEKKDAEEVLNQIDWIETLHKEDMTTASVAERLSLTLQIRMRDLEAETCRRLIAWEDEKNYSAAEKSDVFTQTHDRDTTVDALALASLFKTLESLDSELRDMEEWLHDRAAAIKPLTDDCADIEEENRQLEQQWKSYDMLGVEMRRLLKGLDINEEMEKVLKNPASALVYDEEGLIDVDESDEGIETIYEAGKALEEAIEYPKRSGGIHLRAVVERTQGLRAIAKSFCTALAQIVVTVMEQFKTEVVAGSDYGKVSKSDTHSMIAKKIRDTQRKFQSSLLAYIKLIEILAALSPEMLPALRDAYSELVAEGYFQALPGRNAAHLNRAGKDIKDYNPNDTSPMESVNAPDIRATLNELLPVVAREAYFVSALFGNSSKELDGREKKRNFENARDSVDSATHHFRYYLLRACGIYPDEEPGRPVAEMGVRGDPLLCLVASIYLNEAIDNYVDREKRGGDHSLSLAYIRATILDLRKKADKQWVVWVDMQNDWIRSYDGVPVSGKRAGVFPSFARFPYYIDHLIQCCCEGRDEGYFPDIGNIKVINYYLQKMAATLIESLREFASRESTDQQYASNVMLMENTYYFSQSMKQRGDVISNLFAKQITKASAMCKESTDAYLGWMIKREFIALHELFSRVSKIHRDHGDREVLVHVPKVQFVKTLVKEADRQVLRERIGLMFSRMEKHLSAEGGLLPVAWKALVKVLYEWFGRWEKLSSQLYGHPLDPTAIDIVRIAKAAGGAAKAKTQTRDSDFGLKSMLALRSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU91</accession>
    <name>B7FU91_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_7893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178279.1">
        <property type="nucleotide sequence ID" value="XM_002178243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU91"/>
    <dbReference type="STRING" id="556484.B7FU91"/>
    <dbReference type="PaxDb" id="2850-Phatr7893"/>
    <dbReference type="GeneID" id="7197707"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7893"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323163_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU91"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="85" mass="9990" checksum="19081A7A870FAD40" modified="2009-02-10" version="1" fragment="single">SKERVDELRAKHRRHEKDTGSPEYQVAGMTERIAYLTKHLQQHPKDFSTRRGLVALVNKRRRLLNYLSREDTGRYTELVASLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUN7</accession>
    <name>B7FUN7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178353.1">
        <property type="nucleotide sequence ID" value="XM_002178317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUN7"/>
    <dbReference type="STRING" id="556484.B7FUN7"/>
    <dbReference type="PaxDb" id="2850-Phatr34078"/>
    <dbReference type="GeneID" id="7198107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34078"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_3_0_1"/>
    <dbReference type="InParanoid" id="B7FUN7"/>
    <dbReference type="OMA" id="EKLMRMG"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF80">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="96"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="260" mass="29318" checksum="02AE0078F264E7EE" modified="2009-02-10" version="1">MASSVIRRGGVLLAGGGVYATAVYLTYHYLRMNKEQNLVSADGDNYISYVNNPDRTKKFQKVAEFYDEFIGRDEIFMGINLLRRSLLFFHAKGTVLEVGAGTGRNISFYPSSVDRVVLTDSSDQMLLQAKNKIQRLTVDERKRFAVIEADSARLSLPENAFDTVVDTFGLCSYDDPVLVLKEMARVCKPSGKILLLEHGRSKTWDFVTDHLDKHAEQHAANWGCVWNRDLDAVIAASGLNVRVLNRWHFGTTYYIVCQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVZ7</accession>
    <name>B7FVZ7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179016.1">
        <property type="nucleotide sequence ID" value="XM_002178980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVZ7"/>
    <dbReference type="PaxDb" id="2850-Phatr34419"/>
    <dbReference type="GeneID" id="7199586"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34419"/>
    <dbReference type="HOGENOM" id="CLU_524272_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVZ7"/>
    <dbReference type="OrthoDB" id="49222at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="381"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="520" mass="56642" checksum="099402E03886F506" modified="2009-02-10" version="1">MVKFPKPSLRKRRVGTIARSARCATRDHRRDCPAVDPDRVLCLPENAFQVDHIRHHDRRFPSCSVSWMIEFLTLLILGKYRHHVHSHILRRPVKRLTNQSLLTPHLVGSFRLAFPKCRGPTTLPRSFFLPPDHRPVLVVLSSGTCPLLTAKIPMANEVTENVAAQHHESPADLAFVAPRTNDLSVGSSVEPWRHHHDRNLDLLHNTPNASHSDAAIVINNNLPEAKRFEEGPSKSSTSLLGKRRSPPSEPEATDASQTRQKSGPVVSVEQQASALAVIPSPLSVGTTTGNTAAPVEPSNTTSGEAPPKSPSAITVLNPTQQQQPQTEEEEGGLKLLFAASLLQQTSGDLASTLPTVPVATSVSTPSNNGGAATVAVPTDHDVLCGRGGLINKHPGNVVYRKVVEYNKAVYKQVPKRHRILVPQSIVQTIRNSGGRFLQSTHTSWTEIPPHRAVQKTSQALREKPRGDEDEFELQEDDISAAGNQKNSSDSVGQHNSSDTYIDKNNSNEGSDNGGGWIVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW26</accession>
    <name>B7FW26_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_19427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179030.1">
        <property type="nucleotide sequence ID" value="XM_002178994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW26"/>
    <dbReference type="SMR" id="B7FW26"/>
    <dbReference type="STRING" id="556484.B7FW26"/>
    <dbReference type="PaxDb" id="2850-Phatr19427"/>
    <dbReference type="GeneID" id="7199819"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19427"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_1"/>
    <dbReference type="InParanoid" id="B7FW26"/>
    <dbReference type="OMA" id="YTMPPYV"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000041">
        <property type="entry name" value="Adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004624">
        <property type="entry name" value="PRK05964.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005940">
        <property type="entry name" value="PRK07986.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF17">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="445" mass="49351" checksum="56F7133B281E5272" modified="2009-02-10" version="1">MLMGMKSGKYASLSTEEIVRLDQKHVWHPYAAMPNAVPCYPVQSAHGVHLELTDGRSLVDGMSSWWACIHGYNHEALNDAAIHQISQVSHVMFGGLTHEPAVQLARRLVEVTPPGLEHVFYCDSGSVAIEVAMKMALQYCYNVGQKDKHRFLTIRGGYHGDTFEAMSVCDPVNGMHHLFAKNLPSQIFAPRPESKFDKDEDDKSILQRDVQSVRELLEVNHDEIAAIILEPIVQGAGGMRFYNPAYLTAIRDLCDEHHVLLIADEIATGFGRTGKLFACEHANISPDILCIGKALSGGFLSFAATLTTAKISQKFAQGEAGVFMHGPTFMGNPLACAVSLASLDLLQSYDWESKVQSIENQLKVELEPCRESPLVQDVRVLGAIGVVEMKEAFEMRKVQAAVVNEGVWLRPFGRLLYTMPPFIIQPSELRKITSSMVSIAKRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-02-22" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW84</accession>
    <name>B7FW84_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178839.1">
        <property type="nucleotide sequence ID" value="XM_002178803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW84"/>
    <dbReference type="GeneID" id="7199627"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1800"/>
    <dbReference type="InParanoid" id="B7FW84"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="284" mass="26926" checksum="842DA9E6FD0ED41C" modified="2009-02-10" version="1" fragment="single">LGEALGPELGWELGALLGAALGEELGALLGEPLGAALGPELGAELGAELGPALGAELGAALGAELGAELGPELGTELGAELGDTLGWLLGTALGAELGEALGPELGWELGALLGAALGEELGALLGEPLGAALGPELGAELGAELGPALGAELGAALGAELELGTVLGWELGIELGAELGPELGTELGAELGDTLGWLLGTALGAELGEALGPELGWELGALLGAALGEELGALLGEPLGAALGPELGAELGAELGPALGAELGAALGAELGPELGEELGAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWK4</accession>
    <name>B7FWK4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_34751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179176.1">
        <property type="nucleotide sequence ID" value="XM_002179140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWK4"/>
    <dbReference type="PaxDb" id="2850-Phatr34751"/>
    <dbReference type="GeneID" id="7200322"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34751"/>
    <dbReference type="HOGENOM" id="CLU_1079528_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWK4"/>
    <dbReference type="OrthoDB" id="48412at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="25024" checksum="A9D9BE1821F89B41" modified="2009-02-10" version="1">MAAERVAEIQVCQNKDCCKRWQQSYPSTTLPDILRDLLEPSCFVDVKTTGCLSQCDKGPNIVFKARGKQKLVQGLDSISLLIEALEKEFGKGIVPPKLIAACRVLGKAHEASSFDEKHRFLNSVVSVLEGEPELAQSSALARALVSRAQARYEDQHTEEALGDALRATSMKSTSWNALSWRMVADCYKTLGKPDEAIAALREWGSCEPAFRSKVNREIQELRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWW9</accession>
    <name>B7FWW9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179236.1">
        <property type="nucleotide sequence ID" value="XM_002179200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWW9"/>
    <dbReference type="STRING" id="556484.B7FWW9"/>
    <dbReference type="PaxDb" id="2850-Phatr45226"/>
    <dbReference type="GeneID" id="7200248"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45226"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1247483_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWW9"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF2">
        <property type="entry name" value="GH08893P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855430" evidence="2">
        <location>
            <begin position="34"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="24820" checksum="2BFE3FC4EDFBD3F9" modified="2009-02-10" version="1">MLFLNFFVNACLLWTTGLQLLLLSSGKISSVSAEDAPPQPLQEVKFYNLPSVVKLNDKNFEHETQASTGGTTGSWLIYFHKSRDDTLIYGAVPDNDVLAEHHIVLGAANIKYNVNVWERMRVRGLPAFIYLHRGKLYRYQKPAMGGFTWKGLLQFCFEDVPNNVYEGEPIPSPMTAFSRLMELVRSIQKDGGRFFGGILLVFSILGAAALAGQKKKEKSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXS3</accession>
    <name>B7FXS3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45460</name>
        <name evidence="4" type="ORF">PHATRDRAFT_50220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179608.1">
        <property type="nucleotide sequence ID" value="XM_002179572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185191.1">
        <property type="nucleotide sequence ID" value="XM_002185155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXS3"/>
    <dbReference type="STRING" id="556484.B7FXS3"/>
    <dbReference type="PaxDb" id="2850-Phatr45460"/>
    <dbReference type="GeneID" id="7199004"/>
    <dbReference type="GeneID" id="7200692"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45460"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50220"/>
    <dbReference type="eggNOG" id="ENOG502QUQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389601_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXS3"/>
    <dbReference type="OMA" id="IFHANEI"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="54"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="3">
        <location>
            <begin position="485"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63502" checksum="71576E101F69671F" modified="2009-02-10" version="1">MANIKNLDKSGGIPDYEDLDLAFDDLLESENDPTIFRKPTPSSIENDGELTGSKQRKDSLPDESSHDYILGTLVVRVVAARDLEPASKHSLGKMIFGGAHHSRNKGSANPYASVRFGSTTQRTSEVFDTVNPIWPRSETMYMDVSHPRIPDHATQQPKSGTVPSIVATTESSTQIYEQPGNPPQKPKASTSLATHSIFEKEQVESMLEMNEAKDLYKPSRPILTVAIFHANEIGTLKKYNPSKGDSDDLFLGMVAIDLTPVLTGKTTIFDQWLPLTGTESTRTTVRIVCEYEASDTAPQSLDWVHFTRFCDPADFYPAHGDRLYKVESCDGDNVTLSWTSSEGWVSSFVVHRNMLVCAARHQGPIEFYQDEIQSIAERLGHSPMVDTVQETLRTLPDEGLVSVSVDIFRGGTSLLNRWLDQGVRTIIDDIKFATNIDGRHNPNFEDSLATDTLDEASDSISQAAFARHSVEKSEVESAMGTNLQPLPNMPACPITGEPMIDPVVAADGHTYERFAIARWLHESDKSPLTGSILPHKSLVPNYMLVSSLQECAVISVEEDLPVGNDDGPLVEVVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXZ6</accession>
    <name>B7FXZ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_35250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179848.1">
        <property type="nucleotide sequence ID" value="XM_002179812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXZ6"/>
    <dbReference type="PaxDb" id="2850-Phatr35250"/>
    <dbReference type="GeneID" id="7200604"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35250"/>
    <dbReference type="eggNOG" id="ENOG502SQCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507621_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXZ6"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57551" checksum="A7EF193807E60279" modified="2009-02-10" version="1">MVSTKAAKAAGSLSSKIPYELLAPQALIGLVDALSYMVTAPSLVFYVLQSGGTYGQYGMILSIYSFASFAFKPVLGYWSDKSGGKFRMPYLSSIFVAAFGGWLYFLASAFSGNAAILVIFFGRLLGGIGAAQVIPKENLTQASAVLSMTRIVGMVIAPGLNVFLAWIDKDIYLGSFSLKLDPLNSVGLCIMFGNVAAFFIVYFLLEEPQESTRPRRASIDSVDGRSWKFWKNIFTMDIMVPMLSIFCMNANFQLLETSMAPAASDALGWGPIGVSSIFGTNAFFIFFAVIVTLKLSEWGVSDEGLLKIGLCFSIAGYSLVYILWENPTNVIQFFVPIALSTCAFPFMGAPTRSLFTRFVDKNHYLRNHQGSMQALLSMVASAAGFLAPGFISAYVLRKPEEVAASSNHRELAPLALFAPILSALTLIGFLCLERKTRLGKPLDESSKVDEATSLVEQGEVLKEGDEWIREFHPRVEAYRRNSVTLMGIPQICLDQTPNVASRRHSTAVSLGTHPAAYSEARRATTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA1</accession>
    <name>B7FYA1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_35355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179700.1">
        <property type="nucleotide sequence ID" value="XM_002179664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA1"/>
    <dbReference type="PaxDb" id="2850-Phatr35355"/>
    <dbReference type="GeneID" id="7200389"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35355"/>
    <dbReference type="HOGENOM" id="CLU_344706_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYA1"/>
    <dbReference type="OrthoDB" id="55634at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="19684" checksum="328DF7436C778E37" modified="2009-02-10" version="1">MSASTGQMTSSTVFSHFLDNVFSIPQGHPIRLSFAQQGYDTVEDLLGICENELGTFGYVPPTSLDTNDNPQWTPLLMAHRQILRHFLRWQASLERKKGSSLDNSELVELTSSDFAFYKRSALGQVSSVLTTATSSLSAPGIPNKPRSVFYGQKKPVYCKEDATTLSVNNTNAITKISGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYD4</accession>
    <name>B7FYD4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_12097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179916.1">
        <property type="nucleotide sequence ID" value="XM_002179880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYD4"/>
    <dbReference type="STRING" id="556484.B7FYD4"/>
    <dbReference type="PaxDb" id="2850-Phatr12097"/>
    <dbReference type="GeneID" id="7200435"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12097"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYD4"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000208">
        <property type="entry name" value="Zinc finger protein-related isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="264" mass="30140" checksum="F653933FF13B7F57" modified="2009-02-10" version="1" fragment="single">LGCPHYARACKLRHPKSGRLYTCRLCCEQEREMPMKDQDEPLDRYAVTEVMCIKCTALQPAEDRCINADCESRGRPFAKYFCRICHLYDDGSRPIFHCPYCNTCRLGLGLGIDFRHCMRCNACVSLADDAHHCIPQKLQGSCPICRDTLFQSTEPLRGLKCGHVMHLSCFTQYRRGHAYTCPLCMRSMEDMNDYFALLDAAVRMQPMPTAYLSTLSNIYCQDCDRTGQVQYHFVGQKCLECGSYNTREMGRVHNSPTSTPPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYE7</accession>
    <name>B7FYE7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UNC18</name>
        <name evidence="3" type="ORF">PHATRDRAFT_11956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179924.1">
        <property type="nucleotide sequence ID" value="XM_002179888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYE7"/>
    <dbReference type="FunCoup" id="B7FYE7">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYE7"/>
    <dbReference type="PaxDb" id="2850-Phatr11956"/>
    <dbReference type="GeneID" id="7200411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11956"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_2_0_1"/>
    <dbReference type="InParanoid" id="B7FYE7"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="588" mass="66182" checksum="F84F4A4AACD7D0B9" modified="2009-02-10" version="1" fragment="single">GWKVLILDNHAMRVISAAVGMYDIMEKRITLVESLDKKRAPFPDMGAIYFLDPNADSVAKLVADWSDPSNKRLYGSAVFLYFLGRLPDNLLAQIKMCRPLLKRVKGLMEINVDFLAVEERAFTFDMRHAFPSFYLRRGNTPIELDIAEKLVTVCATLNEYPHIRYKQSSGICTSLASVFHLKMDEYVSQNPSWWYHGGPVKNQAANRERGTLLLLDRADDCLTPLMHDFIYQSMVQDLLKMDGDRITFQAETKNDPSRTEAKDVLLDDRDSLWVELRGKHIASVIETLSGRIREIMNSSTGSAFGGKKQQQGNLSISQMAAALKALPEYREVMSKLSQHMHISHECMEVFKHNGLYNLSELEQTLATGKDEDGRTPKLSDIMERVEQELLKMRDPKARLRLILIATVSQGGLRQQDRRRLMGAAELSRKQIRTLNSLEILGLSIFASTEKNRLVGRLSSGSTSDDESEYAASRYVPPLKHILSELVNNRLSFEDYPSILPMPESNPSLSTPSARGSVRSSRKSRPSGAINLSGGRSIAFMMGGMSFSELRIARDVMEKEMREVIVGSTAFISAKDFVDDLALLGRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ15</accession>
    <name>B7FZ15_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_12436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180078.1">
        <property type="nucleotide sequence ID" value="XM_002180042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ15"/>
    <dbReference type="STRING" id="556484.B7FZ15"/>
    <dbReference type="PaxDb" id="2850-Phatr12436"/>
    <dbReference type="GeneID" id="7201120"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12436"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851169_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ15"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20071" checksum="7271A3E770A0937C" modified="2009-02-10" version="1" fragment="single">ILVVGGPGSGKGLLSKRLEKECHVVHLSSGELLRSEVAQDTALGRQVRDIMDRGELVSSAIMVALMKKRMRDHPGKRVLLDGFPRSLENAHDLVTLCGRPELALHLECDDTILLERILQRGADSAPEERRADDNFQTALQRLRTYHAFHNSTIHWLREQHVPVVNLDCSGTAESVWQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ22</accession>
    <name>B7FZ22_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
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    </reference>
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        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="113" mass="12289" checksum="72CE00B530617F9C" modified="2009-02-10" version="1">MSSIRTAVSIFEATMRKNEELGCSDKSYISVFAKQFPSASHYGKSRGRFGSTEIQSDASSSVGQQHPFESQMGCEISVPDTTESSYSIDCSDNSFDLAISMPVQVRSIAIDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
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                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="Lucas S."/>
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                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180085.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ41"/>
    <dbReference type="PaxDb" id="2850-Phatr35734"/>
    <dbReference type="GeneID" id="7200996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35734"/>
    <dbReference type="HOGENOM" id="CLU_1345505_0_0_1"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="204" mass="22273" checksum="924971C05B9A0310" modified="2009-02-10" version="1">MSTRSVETRVGVLEGQLGVGSTFVDSLSTTTDIAVTLRMDALEQQYSSLASPSLTSIWDESDKLLQELDPGTALTYQQQIAAPILYRRQEVLACADDLKASLDELSQISNFLLIGQDHQESQTKAQLKEHQVTQAPILVGTIVSKELQSRLSAVEATVANIQNRAEQAAARLDAMLSQYHSAISIASEKLVLADEEIRSKEQSL</sequence>
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    <name>B7FZP9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
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                <person name="Martin-Jezequel V."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179985.1">
        <property type="nucleotide sequence ID" value="XM_002179949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZP9"/>
    <dbReference type="PaxDb" id="2850-Phatr35540"/>
    <dbReference type="GeneID" id="7200781"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35540"/>
    <dbReference type="HOGENOM" id="CLU_353946_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZP9"/>
    <dbReference type="OrthoDB" id="56787at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852807" evidence="2">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="481" mass="52090" checksum="674785E9DDE0FC5E" modified="2009-02-10" version="1">MISSSVLIGIFFSLIGVYAEEISLEPRESFGKQKTRNAQVILANYSEAEMLGFKIQHQVHSQADLFVQQLVGKLLLVKNEMISLENRDLANLDIFTSYASVVADGTEKNAASSLFVSRQDPAITIALESEGNLREAVRLDPEIGKTISISRIDSRKADRFVTITAEDFDQDKLASFEVEDRLTQERNKQREVSPSLSAFGPSPGSKIIPRDSTESCCFAPLDSQELASMNISSETKRTENSVNDLSVNQSVENDNVVSAHATTREPKTEYKYETRESQTLEGQWNIIGKKGKSTISHDIGTKSSFIVKVIGACSEYGFDVIEVAVVVDSLLCAAVGGTEVAASTVAQSVIAGASQFYEVDGLCKKLRISYLEIHCNAGTDPIAPLLQRAGNSDICNTDANGLLQNFVRYTADQGIAADLNLLFHGKSFTGSPSIGCAFIGALCRIDGADSGVNEITFTSDPVSRAKLVAHECARLATCLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0G8</accession>
    <name>B7G0G8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180675.1">
        <property type="nucleotide sequence ID" value="XM_002180639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0G8"/>
    <dbReference type="PaxDb" id="2850-Phatr46212"/>
    <dbReference type="GeneID" id="7201285"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46212"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363889_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0G8"/>
    <dbReference type="OrthoDB" id="406235at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="7">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="768" mass="80986" checksum="1B2FE4843319FEC8" modified="2009-02-10" version="1">MNRSYGMAAHGADGPDSDDDDTMSDVFTMDGDYTLSSGMPPPPATERSHTHIPLTVESPSATRSQGLNPYSPRTDAAAYDVSTDDGSVSGIESMSGLMTTDGSYFQNDTVVHDDEMSFQAKVQAETNKILSEYDMEEDLNRSGDSKLGRYHNRTSVSAPRQAAPPMTPTSSMDDDSDSEAARARPDNQTRHSKKDPSSAVGPPPVSSNGARGSSVRHSVRSLRKQSNNKPEAPTKPAVYDLSTPETSPTNRKAPVTPQTKTPQRSNTTARPPNMIVVGSSTTTESSEKNTRAAAAIGASAAPTRKGWLGSRLSFVIIVLSIILLTAICVAVGALVAAGNRNSDSSSASSSEGGSSNEIGAPPVDFLPFLPPTTAPIASEIPSTGSPTPEPSAWNRDVCGIDDPDKLVFLGEGTGDRSCEWLSGRPNVRDQFCQPGLEPFIYCRETCNNCGPAEGDTTDAPTAMPPPTSTPTSEPVMITAFPTRAPTSAPTPAPTLVATIAPVIIATPAPIAVATPPPTGTSTVGSAITNAAPASTAAALQNPASAQSRALAFVENSSATAALPESRIVQQFALATLGFRTGLAGRRLEEARQLQSWMSGTNECSWSGVTCDSQSSVIGINLSGRGLRASLPGELAMLSNLVTLDVSVNEFFGTIPSDFGRMVNLRTLRMEQNGLTGSIPNTMRNMRILREFYVEWNELTGDFPNDVVLAMSSLEELSIYHNNIAGSVSDAVCALGLDELWIDCREVNVEIGCWTRCFFQCGGSTGVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Z8</accession>
    <name>B7G0Z8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_36312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180950.1">
        <property type="nucleotide sequence ID" value="XM_002180914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Z8"/>
    <dbReference type="PaxDb" id="2850-Phatr36312"/>
    <dbReference type="GeneID" id="7201908"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36312"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009133_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Z8"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="210"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="463"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="530"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="740" mass="81842" checksum="943541E0C6B0E896" modified="2009-02-10" version="1">MTEDAGAGTIAFLQRSLQANNSTDSTEEAASYNDGSVLRDTFTVYGSILLVIFIAFCWLRRKYPRAYNVRNWVEDIKTPLAKDQFGFFSWIWEISTITEDEIMDECGLDALCFVRILSMGYRISLMGVFNAIWLMPVYATADVSDDTRGIVDRIVEVSIAHVPASSPRLVATALAAWIVFGYTMYLILQEFEWFIDKRHKFLAKPRPQNYTVYVRNIPIEYRTDSGLEDFFRQCFQYESVLEANVRLRTPNLAKLVAQRSVLIANLEHAIAIEDITGEAPQRSASLKSSLMIMGGEKVNAIEAFAEELKALNADIKARIEELETKKLSQLFMQDVEQQSLATLGHSVAGRGDSMYGAGDNVNAEECASLTPSALAVVPRPNGYGTEISNVETAIYNDVIVEEEDDDGDLSTLASRQNVTNHSSSSKSILDAKKSIKQSVHLFKKAANAVKDSAVAVGENAAHMLQTNADGESYEAGFLTFTNLRTAQAALQMLHHSKPFSIEVQEAPDPQDVFWFNVGRTHKELQMGNLLSLAATTALCLLWTIPMSFIASLSTIDALRSEFDFIDSLLDDAPFLVPVFEIGAPLLVVVVNALLPVILQVFSMMEGPVSGAVVEASLFSKLAAFMIIQTFFVSAISGGLMQQLSEMINDYTLIIDLLATSLPAQATYFIQIIFVTTVFSCGMEILRVIPVIKAALRKCIGPRLTKRERQKAFMGLQPLGDPLDFEFADFSSNMVSSSRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1D2</accession>
    <name>B7G1D2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180834.1">
        <property type="nucleotide sequence ID" value="XM_002180798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1D2"/>
    <dbReference type="PaxDb" id="2850-Phatr36444"/>
    <dbReference type="GeneID" id="7201569"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36444"/>
    <dbReference type="HOGENOM" id="CLU_991962_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1D2"/>
    <dbReference type="OrthoDB" id="47383at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="32071" checksum="5406A614ACF8EA61" modified="2009-02-10" version="1">MPPRSLSLRSSPSVMGWSDDYSLSSASFDVNAKNNKVRLPLTKSVKFSECNETFEVTHLDDMTNKEVADTWYDAKEYSAIKAGYQYTIFLMEAGEKIPQDDPDNTTRGLEYRTQEGAWARYENKRDAYNAVLDEQDRQWKVDKDDEQRIRKIYLDHSTKCADAAVVRGVKDEREAIRLHAEERARLQAAVKRAAERRAKKLAEKKKLKKLLSESKSIADETKSVTSKKSKVSSETKMKSTVMPEKKEKKLKSALSSSSLGDRKMKGTTSLRKKLERAEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1F7</accession>
    <name>B7G1F7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_36468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180849.1">
        <property type="nucleotide sequence ID" value="XM_002180813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1F7"/>
    <dbReference type="PaxDb" id="2850-Phatr36468"/>
    <dbReference type="GeneID" id="7201584"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36468"/>
    <dbReference type="eggNOG" id="ENOG502SUF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753284_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1F7"/>
    <dbReference type="OMA" id="RNNCSHQ"/>
    <dbReference type="OrthoDB" id="48175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="368" mass="41334" checksum="36C248CDB7CE6018" modified="2009-02-10" version="1">MASSPSDKSTTSNPSTPVTPGDETTMETNSPLLSPQSMANAALANAVFAQQAQRTVKLAFTQEKDIPVNENGETERRKQFSDDNKDEERNNCSHQQLDKNNAVESIVKDPKSRIEAIWGSSNSDHTNAWKTTAELIRSEIEALLKLGTEAYQAAEFQARESKLLQDELDGKDDELERLRLAESKGRATIVAVKNLQCSPLTMRRYTLVFIPFRQNLLRQGETSKVDARDASRAAVSEAGLRAELGVVTAQKNESLGQAEGHKRKATLYEDELRQVKTKLARVVQEKIRIERDHRATLSLAKSFDSHVSSDVDYYKRKVSELNGYVQNLNAVVAEKNRQIEDLRRQIERSMSQNRLAQFRADTPDTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1R6</accession>
    <name>B7G1R6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_36581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="GeneID" id="7201860"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30487" checksum="102D2B647991EA1A" modified="2009-02-10" version="1">MITCFGKTVAPMGFFGAAKKQTDEHMTSYGSHISVIFQVWGSKWPTVFPYCLFNVCVMVILSFVDSHFDGKYSVDVSTQGHGFLTLVVAFLLVSRVNTGLTRYESARDSIGVMYRECRELVQNVCVFTELVQRGAHHDRSQWEDGMRVPIRMAYLLRKTICSQAGRLAEPMAISHENKLLTFAHCFEVFLITYGFMGLEVVAMDLDNPFGDDPNDFDNSALACTAYEDTYLTILDIDGDEWMNKLRFRVHGQEGDCPFPDEKTSLLSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1U5</accession>
    <name>B7G1U5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180915.1">
        <property type="nucleotide sequence ID" value="XM_002180879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1U5"/>
    <dbReference type="PaxDb" id="2850-Phatr46606"/>
    <dbReference type="GeneID" id="7201736"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46606"/>
    <dbReference type="HOGENOM" id="CLU_450168_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1U5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="607" mass="67286" checksum="8AFE3565BF176A04" modified="2009-02-10" version="1">MKRIKNLKRSSFQEPILSKESSGSMDLSDGDENDAGSANVLTKRTKNLVFKKYMPKFRKLVDCEYEDPSASAYEPPPKFYCSMKLPEKVEAAQPKIFSQASSRDAFARFQRLDSPVSLNEGLNSQFPMDFNNKSSASKRVGEPQRDDSSGRQEYHPPTFPINTWQGKRCFSDQTKKTFDVRDNNIHSEIEALFNKNAELEDASEAVAKSDEASDEFRQFVFDESFSRIENVTVQKSDSGVSNFVASSVAALTANLTQNIRQKATPMQRNGKKPISGQTTSTTKLSVKELKKSFKDSAFHKRASKIGNSSASNSSSFRPPHSLSKHKTCSVSSNGPPSNASVVSSQTDGNNPFFAKDDATEVDPFDFTSDANHDDVDWDVPLEKSAKTLEKTKTFSSAFAAKFDKTMNKPSKVDKRMIKPSKVAQNVKTSTSMDNNALIQCIRNSVSDVRSTKPDPSPRGAASITSYMARKSHKSSKRKPLLNAGAKVPRNPVKGDGPKGLPNNAILGSMLFRHTSPTLAKRFDDDDEEALLPDVPPAILTAASTESTVSSVTEEASSFYQKNFEGWNKQAYDALNHFHRMRKSDPKRYRAGGRLTSVEEEHRNMFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2F9</accession>
    <name>B7G2F9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181373.1">
        <property type="nucleotide sequence ID" value="XM_002181337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2F9"/>
    <dbReference type="STRING" id="556484.B7G2F9"/>
    <dbReference type="PaxDb" id="2850-Phatr37212"/>
    <dbReference type="GeneID" id="7202174"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37212"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673486_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2F9"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="321" mass="37521" checksum="8254AADF402956B1" modified="2009-02-10" version="1">MGQSQAPINPLCVYSASQRKPKKNRSKASSRLVGENRNLEKCYLRLTTFPRKQDVRPLDVLRQALAHIKAKYIQEEDFGWANEQLKSLRQDMTVQRIRNYFVLSVYETHARILLEHGNLNEFNQCQTMLRSLTDGDRAGRDSELNDILFETDDEGDFHFISLAQSRKTADEFRAYALLYALVQRCWSTLKVDLVRAKASMRDLEAEELESASRHALRVVTAVNTHDYRFFFRLYEVAPNMSACLMDFLVKRVRDHAYQRIVAAHRPCVSVEQFREWMVFSDLEETRQYLNERGAIYVYEQGEAPIWVDCKQSMVGNEWIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>B7G2I8_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181387.1">
        <property type="nucleotide sequence ID" value="XM_002181351.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="2850-Phatr37241"/>
    <dbReference type="GeneID" id="7202028"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37241"/>
    <dbReference type="InParanoid" id="B7G2I8"/>
    <dbReference type="OrthoDB" id="121467at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
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    </feature>
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            <begin position="168"/>
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        </location>
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            <end position="251"/>
        </location>
    </feature>
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            <begin position="252"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="281" mass="31248" checksum="76145390514A2399" modified="2009-02-10" version="1">MTVNGKFIGFSAGKMACLDVNEMAITSPILGLFYDFGESLFKEKTLNIWSVKAFVLPEDEGMSLIEEIAAEAAEADMEAGNWMEESVEAPVAEIVETPADIETCTQSPNLESENPVATVHQTEWYVNERKTQLDVNGHVYIRHFHIRTSVGDLIGQDSDNEPENFFGSLESSYSPQSLSSVAGPNYGPRLHPPDKEGDKEDEYLPHGIGKSAGREEKQKDFYMPLAEELVDNQYNSVGSRKVGRDELDKDSPTISRTGEPQFGLSTHLTPTKRKRKNKDVL</sequence>
</entry>
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    <accession>B7G2L5</accession>
    <name>B7G2L5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181227.1">
        <property type="nucleotide sequence ID" value="XM_002181191.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2L5"/>
    <dbReference type="PaxDb" id="2850-Phatr37268"/>
    <dbReference type="GeneID" id="7201931"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37268"/>
    <dbReference type="HOGENOM" id="CLU_236604_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2L5"/>
    <dbReference type="OrthoDB" id="49690at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="781"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1865" mass="210058" checksum="8A7DCBC9C5BBFA0E" modified="2009-02-10" version="1">MSRRRTRQKGIGRMPGVSFEALWALGQGVGSVNKLVRRTVNDSNGDPVETHRSIMLGKLATQLAQQRLMFVEKPATDDASRRPRSHRDTRSLGKHAAVKQRMKAQQQKQGQTPSPSQKRFRTVLSIETADATASPSLAEPEPHTEPLRVAVTVDEDDNQGAALPTSTPVLGNSAPSDLFRDVEAALHTDCDIHVSLDDEPEVASQTRDGSYWAMFGDTPERWTGIDMTEEVAMSLLDTSLISVSTKEPEEDDYDGKDSHGDDAPATVNKTITAATDTTPLHFWKTWRSQPVTPALVRIQSPSFTAEGATPDDPERHFRNVDSEQPLYAADRVAFTTFRQNSTQIALQESKTYLDRIAQLEEALANAEYERDCETQRRIEAESTVSVLQSPSSSVPNHPAPTPKAMLHPPVPSTPSSLPDVESLWERNKTLVKEVRFADQTCMELSSEKTALEQRIEHLSENITRLDQENTLLREQLGRAEETVRQVKTDTETDNAASPSDKDRTRRALEEFPRPIDRKEGMGPSLGEHIANMASREPSTMENPSDRCHTAQSENPSLRERLEVTLEERTAALRQCESLSARVSELEALEGRHHRDLETTAARYDDLFRQLEEAHQKLTVANQTIVEGDECRELLQRRLTSDAQRTDELEQSRLLLQKANDDVALWRTKFADGEGEIRCLEGRIRELTSSGHDSSRAAGLLRKELGKVAEEKRELLVELEAANEKLAVCETKLEQFEKDGQELEATRSELDALRNEETLRNEQHTERERQFSSKLADTLSRIETLELDAASAIKQKDEQSQELDAALGQLDCLRREIDDLKEARLSDENLFQQKLSRASCDLEVAHTDIAVARDAWRQKESELLWAVQKVVAQTESQATILEERLVNRHGELVARMGQAVEAVSYVRESIIFGDSTTAVDTVSAAHGLAESAPATPLPSDGALDATFDNPGGASTDLELMEEARPHGFAESYGVHETEFDFTVSLPLDTDTMSSIAGISHLFSLSPVSIDQSPMENTHNTTTLLRPRGKELQSPRRRINELICRTSELEEQKEIALQDVIVLQQRVEELESELHAMAKDLSLACKERNAVAKISNFHNGCIEATLKENDTNLCQVEKTDSDTTASAVSIHVNEVIESIFSRKGETFISESEVADKVSRSERDIEGLGLDRSILDQRLTTTNDKKGEIAVALVADNEQIDDNTSEIVSLRLHCGSLSSDTDKVVVLRRLEDLEAKRDSMRDSFSSIQDLPKRNERKFFESRFESMTNDCAKAKERIEELEALLGEKTKQCQELEAHIATIQESYADAKVEKQIIQESMEISLSQKIAESQQAAQIRLSASEEQLAIARDEIALLHSLHKSVTSEKKESATKIASLQEASSKQLTELKKANESLDIIGQERDDLLKSLSKLQFENADANSEMEKHQEALFETQESLTECQLKLSVLDAITTERDSLLNKITELELECTGLKTTMTESSATERKSLEHTLSSLEEIQVERKSLLENLDSAKIENGLVRKQLDSMKAELEDDKRTSAKLRELYEQQVEANAELRREVFHCKGLVDDSDFAMQDLKEKYLECNEKLANFCFLHNSNEESKLMYDRARESAEGLAIESQRHLAKAREDLETALSENGKMQAEYEKSQEVLSDVRRELAERKEAIKDLEVSREAAIMGLAEYKEQLNSLEISLDKRTQTVNQLQADVKERDDALSKLDQHNAEINVWEKRIQESNDALSRLQDQLDESTASLRTMTNEFKMASTRSDHLELKCSRLRDYIRKVTGKCDQWEDFYDRQAEVVEGLKRANERTRQKTAELARRYQERDQIHDKERAVWTAQKCNLDFIHSQLEEELHGIANELAHVESRPPSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2X7</accession>
    <name>B7G2X7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181281.1">
        <property type="nucleotide sequence ID" value="XM_002181245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2X7"/>
    <dbReference type="PaxDb" id="2850-Phatr47232"/>
    <dbReference type="GeneID" id="7202206"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47232"/>
    <dbReference type="eggNOG" id="ENOG502S1DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453069_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2X7"/>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="3">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Zeta toxin" evidence="3">
        <location>
            <begin position="292"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="492" mass="55886" checksum="8263C19824E91A97" modified="2009-02-10" version="1">MIITLIIAKTDSGFTIASLKIFSSIPIPLVFASIRPSPGLFLAPAYKALRMLPEFSTFCENSPTMVDALTSKEGGYIAETLTLAALQAGRNVVLDSALKDVNWYKDYVERLRQEFPCLKVGLIHIIAEPEVILKRVRLRGNETDRSISEEQIRKALQSVPHNVSKITPNVEKVFVIRNDDSPRLEGCKWSEFAKTFTQIPLSGKLALGERMDMSGTVFRRKSCRRRFSVFQSSEDNHKADHKMFYGKYAHIRKTLDYNYHKNYTFERQRFQDAIVSEYVNNAILSDNNGELCTTPTEPWIVFTAGAMGAGKSYTMRRLVEKGRFPLIAFVSVDPDDIRRHLPEFHLYVDQSPELAGELTRKESGYIAEILTLASLREGKNVLVDGSLRDWSWYKSYFERLRNEFPALRIAILHITAPRDAVFQRAADRAVTTGRIVPQELLVAALEQVPKSVEILSPLADCSVELKNAPRAEDIELVTPNQTWETFESNWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G484</accession>
    <name>B7G484_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182030.1">
        <property type="nucleotide sequence ID" value="XM_002181994.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47598"/>
    <dbReference type="GeneID" id="7202812"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47598"/>
    <dbReference type="HOGENOM" id="CLU_244446_0_0_1"/>
    <dbReference type="InParanoid" id="B7G484"/>
    <dbReference type="OrthoDB" id="49621at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1548"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1597" mass="174280" checksum="58EACA5B115E45E1" modified="2009-02-10" version="1">MSGTARPSRRRQSVRHYTDDNPNTFTVKPSRSTAVDHTNPDDHHNPGGRVRARTTARRRPSPPVVVNHNPTRKRRREETVRSETHSNTVRTTPHNNNNNKTSWVTKLVFRQRSMVPASDGTGDTAHRPTDTCLSHDVSFQPLWWPANDNNNNNNNSSTTTTPSTGVTNRVRNTLPPPPPPTWTPLRPASAVRLARDGHGEPLQLPPPAITSWENRRDGGGICVGDAAGTVTLYYGDPSHGIPGQSLDTTAALREAQRPILSKKVMVYPNAVTHASWQQHVVVLETLSELEAWNVRTHTRLWTLPLGNARHDHDEAATNDSNLPVGVTTTPPLVPLDLQVWPHDATQNHTDYSCRVLFLPSSSHVQLDVSTITDDAEASHPSLDVVKLYCLEFSTGTTASLPASPSTTLTTKRTTPRIRSLVPEGYNASTFLCHAAVWDTPGAPHQPPRMALLVAQMFVDDTLQLLRVDTETSGEADNAYAIIRDQSALTAVPSKTSVLDCSLTLTPDCVLICTPRGIRCHDRATLQPLTVYGEHVALHGQTVCWQRCLWVPEPASTGRGGAAVSASGPFEKAATVTNKKKQSWWTRADEVDARLRFDQTNGPNEPPVPQVSHYVLVGLPHPVKGPEDLNGTIYIWKPSQPHAPLLTLPAPTKSGGLLNLHVQNSADGWKLATATFEHGQGWEMRTSLKSSFAGTMYPVGYSVIPDNVEYVEDEDELDTLMVPAPEVDDESDNAVSDPIPKTPPSDQDFETALRLSLLEQHGKQSVSSKQSRDPQDEEVSVLDTDDGSADNLLLPTRLDLPLLQFLQRESNETVVNPLELSPPSGHPKSIVNVVFSSLPQFGSVKQIYRVHRRQAEEAAMREQLAASATASLTTMAVVPKPKSKRTRTANVEALLQASIDPTLRRKMLAAGKQWAEGDGSRLRGTELHPDADDINKGSLAKPPPTKQELVELASQEEKELAFELLCLSPSKPSTPKAVPDHEVEAGPFAVPEPKTSSWKANGTVAPPPPPTVMSASTNVVTALPEHSPPRISRVTDATSPISVSNGVLATHNHACPMSCAACRGRMVRHVRGKREKPVDYDAIARKEREIKEREEAEKQRLKAEKRRAAEARRREARRRKKEEEAAKRREDDEKHRQESERMRLLEQEQFERARILERDNEPVAPAPMPTPIQLWTEESVPPQYVPPPPPPPPPPPPVALERPTAIPSFSAINAATVASTSEILPSARLPDERSSLTFAVSDGNGQETGVHGFSPNSPGNSNGGSPGFPLHVGSQPPVSASNIDSTSAGNTQEGQSQELQEASDRFPGQSEFQSLDAADSGQNDVFRSEGTPGQSLERTSYNTKWDGGYRGGAPPTEYYQSVDASRHISTASHHNQNVGTGDDQPSPHQQYCQREESVAAKSYNHRSGTEESPAHNFPTVPLENAPPVIHVSDFVASEPLSTNDALAALAGLANSMMPEATEEIVDYGQQPSGIASSGVGWSYGGQEEAAPRITYDYAGSSDRRSAILAQFNAENKGETTDSSLYQAYGASENNGYAIQNYSAAVDQDYHTPISDSTQTGYTESQQQDANPVYISQAPHTASSDYVQKQEQRKEQGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4B4</accession>
    <name>B7G4B4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_37885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181883.1">
        <property type="nucleotide sequence ID" value="XM_002181847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4B4"/>
    <dbReference type="PaxDb" id="2850-Phatr37885"/>
    <dbReference type="GeneID" id="7202670"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37885"/>
    <dbReference type="eggNOG" id="KOG2352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G4B4"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="219"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="365" mass="41429" checksum="7EDF3A42672637CF" modified="2009-02-10" version="1">MSRARNRSLLRFFGTLLAREPGCCQRENRRNFSKSLARRGSETVLILVPIYPIFNDSTPKCPRAQLVQSAFIPPTPTYVNPLNRKICDRNNEEYCGALDLLSVDEFALESWTIAEAADGIMSLRGRLIIDQIKRAVSSYFSLPVPPYGNPSYWEGCYRSLGPNDSFEWGHISFEDLHRYQYRELRYDPVIRSDATKPQDPHIQTTFGDTLRAYPHSPSDEHILILGCGNSKFGESMVEHGWNGPIVQVDVASRVIESMSQRCQEQQRKGDMLFVQDDATVLSAFHDDKATAVFDKGLLDALFCADEYQQCFDIMSSIHRVLQPGGVYAFLSFSRPQFLMDKILLPPGHEKRKGPVRHARDGAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4B8</accession>
    <name>B7G4B8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181884.1">
        <property type="nucleotide sequence ID" value="XM_002181848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4B8"/>
    <dbReference type="PaxDb" id="2850-Phatr37889"/>
    <dbReference type="GeneID" id="7202673"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37889"/>
    <dbReference type="HOGENOM" id="CLU_1424040_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4B8"/>
    <dbReference type="OrthoDB" id="10543113at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21307" checksum="0F62F30D0055589F" modified="2009-02-10" version="1">MDPVAKDHTQEIPSAGRRSLVGSSASFRDEGSQAFRYNDGDEDDQSLKDDEADFINRLFTTVDAPCRGVSMCHTSFEDKLDLFSHCRQPLDFWSFLRKHNTHNGTGVEMMPAGTYVVPTFCEYCGASHTSQCKPNCGRPPLFFAKKRPPFQKPDSKRWNSETDEEIAPQVSRSVQTTKSWVAGLFGGKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4I9</accession>
    <name>B7G4I9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_14356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181924.1">
        <property type="nucleotide sequence ID" value="XM_002181888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4I9"/>
    <dbReference type="STRING" id="556484.B7G4I9"/>
    <dbReference type="PaxDb" id="2850-Phatr14356"/>
    <dbReference type="GeneID" id="7202695"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14356"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_3_0_1"/>
    <dbReference type="InParanoid" id="B7G4I9"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="64" mass="7367" checksum="FF89CEC7D5C02214" modified="2009-02-10" version="1" fragment="single">VQDRDAIKKTFQFADFSQAWAFMSRSALLAEKMDHHPEWFNVYSTVEITLMTHDCGGVSEKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4J6</accession>
    <name>B7G4J6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181925.1">
        <property type="nucleotide sequence ID" value="XM_002181889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4J6"/>
    <dbReference type="PaxDb" id="2850-Phatr37964"/>
    <dbReference type="GeneID" id="7202881"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37964"/>
    <dbReference type="HOGENOM" id="CLU_1528102_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4J6"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="176" mass="20212" checksum="A71700372365D70F" modified="2009-02-10" version="1">MKLGCCGKLDCEYKNDENDVHGGQWIRIDKGPSGFGKLTFIEEQIGRMNPLVRNLYKRIITVGKDYPAGLDHVRVQWKKALRDPNNCPACYKSPATCESEQACQEQLLHAVNRGRYMVKEMIGVIQLKKYRTLKQRYGQQPNAHGNDSALRIAMRRLEEDGREKLQDHDPTSRKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4S4</accession>
    <name>B7G4S4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182123.1">
        <property type="nucleotide sequence ID" value="XM_002182087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4S4"/>
    <dbReference type="PaxDb" id="2850-Phatr47752"/>
    <dbReference type="GeneID" id="7202737"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47752"/>
    <dbReference type="HOGENOM" id="CLU_418887_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4S4"/>
    <dbReference type="OrthoDB" id="48431at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="683" mass="77213" checksum="74505667FE25690B" modified="2009-02-10" version="1">MCRGRLSAHIQAHKLLPFGTKPTAACRIMNVAVTNAPLRSLSLSEKEKLEEDDKDSLDTPRIEHEEDDEVRLAMEMALAAAQNPKLSATAIRKLVGETNKQAEIVNEVQKQKEQRKREEREEARKRWMDHKEKAAAWWKGAVSETATQLKDAAAHRAEVLKDQAERRLYADDIKRDETILAMRKKMRVLKKTLKAHRLQGNRVETRHVFKRQRMERKLLQMAEKLSKTQSLLTETNFNVHEYAKAMLRASKKWHKKGTDEELSLEAQLCRNMHQMLTIEKQKAKVKKETREVKKYLQRCKGWLDDKRALCEMHMMTLDATANSMLSLYEDALQRQDKLITKLKDSAEFKDTDLSEVDVSHFDLLPKMAGPGAFLCALRGLPIRDSLHKAKEQMQSTKAAFKSSTDVAKSSKSVKTKHLNSQPELYIETKDDDASISSRLSDPDEPDGVAFGKKSFQDSISEGDEFDFGSDAPWMTTTADLVDVSEEKERSGREQKQLISTQKLPTSAMANFAVSTPETEETIVHFGGERTTNSKGQEESINSGDAIQEISSETAVETQAGAADFSTDTELLQQDTVEKDVVNHEDTANENPAEYLENHLYSNSLVDSLDEVGDTINNISENPMSISDTTFQRETMEEVLSLGISKDPSSLENFYDERKVAIPEAEVEYPEAGDEPINNSDCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4S6</accession>
    <name>B7G4S6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_47754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182124.1">
        <property type="nucleotide sequence ID" value="XM_002182088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4S6"/>
    <dbReference type="STRING" id="556484.B7G4S6"/>
    <dbReference type="PaxDb" id="2850-Phatr47754"/>
    <dbReference type="GeneID" id="7202738"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47754"/>
    <dbReference type="HOGENOM" id="CLU_677008_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4S6"/>
    <dbReference type="OrthoDB" id="48997at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="407" mass="45016" checksum="D57C3A42E4085BE6" modified="2009-02-10" version="1">MYAVLYGATDNNNNNNNGTNKTGSDGSGSDKDGRPVFPFTSLGNGKGDNGTNISIRGLTLLLTFLTVGVLFCVLLPFVIPRLRRIWRQRLETNNEEDHRSSVDEQGRIQLRYSAIESWLVSKQVLAHDDLCRRVLQHNGKECWEPDTSAHGKNRSKERTMTVETLMSADDDSNDENHGEIWSECDNENEGLECPVCMDSIQVGAIVSWSANPKCRHYFHHACIKEWLLKHSDCPFCRECFLPTDQMPSKLSMKHISELIVAQQHRSAHCFFCLEHGVVALPNKLEACFAVDSDGTKALWQRASAVPSRQALVTLRKVNHEQDYLNRTGSSQEDEDDLGNDSVGFAQDSEFNATALNSNEDTSNALSADASSEEVDIVPQAGSSVTVAFGGADGTVVDADDGGFRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Z8</accession>
    <name>B7G4Z8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma-70 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_14599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182327.1">
        <property type="nucleotide sequence ID" value="XM_002182291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Z8"/>
    <dbReference type="PaxDb" id="2850-Phatr14599"/>
    <dbReference type="GeneID" id="7203052"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14599"/>
    <dbReference type="eggNOG" id="ENOG502SMZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563203_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4Z8"/>
    <dbReference type="OrthoDB" id="201574at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.601.10">
        <property type="entry name" value="RNA Polymerase Primary Sigma Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF47">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA polymerase sigma-70" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="317" mass="35770" checksum="D18C4C490C781AE0" modified="2009-02-10" version="1" fragment="single">LTKEEEAQYSFQIRTLSAALALREQLVTLQDGMHVHPTHQEWAAACGVSAVELRRVLDEGQQARAALVAANLGLVTALAKRQLSTLQTATEAGRGVGTILTLQDLIQEGTLGLMKAAERFEPERGWRFSTYATWWVRQRILKSVSDSSRTIRLPAHVHGTLQRIQKAKAWFQAHGEEATLSSLAQYLELPVEKVRLYTDSSRNVMSLETPLKGRSAFKDENTRTLGDTLASDEKTPEEDVEAQALRLDLEHVMTQVLTDVEQNVLRRRFGLEDGTCWSVEETARQLGVSRDRIRLVETRALNKLRHPQQNYKLQSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G528</accession>
    <name>B7G528_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182344.1">
        <property type="nucleotide sequence ID" value="XM_002182308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G528"/>
    <dbReference type="PaxDb" id="2850-Phatr47833"/>
    <dbReference type="GeneID" id="7202972"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47833"/>
    <dbReference type="eggNOG" id="ENOG502SBU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1698952_0_0_1"/>
    <dbReference type="InParanoid" id="B7G528"/>
    <dbReference type="OrthoDB" id="41419at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36776">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36776:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853003" evidence="1">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="155" mass="17617" checksum="439BB2149BE9B5DF" modified="2009-02-10" version="1">MQSIFIFVLCLTALVLHSSHAWTISPHLLTNRRISTPTARAMVQSVSLETLSDNHEEIASELSGSVQRWLDAEWMEQEVHVRMAESCKRSYLDCRERGEADLMAVMVQVADDLTENWRQYDKDAFVNAWDVSNYVSDYLSAKTGIEGCECSSTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5W8</accession>
    <name>B7G5W8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_22166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182618.1">
        <property type="nucleotide sequence ID" value="XM_002182582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5W8"/>
    <dbReference type="PaxDb" id="2850-Phatr22166"/>
    <dbReference type="GeneID" id="7203427"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22166"/>
    <dbReference type="eggNOG" id="KOG2474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5W8"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003243">
        <property type="entry name" value="PRK04201.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF205">
        <property type="entry name" value="ZINC TRANSPORTER ZUPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29675" checksum="A3D59BCCA0763AC8" modified="2009-02-10" version="1">MSEGSVNSENVGVAFGLVIGAGAATSLGAGVVFVPALVKLASRRTLAAALGLSAGVMVYVSLVEIFNEANRHFEEAGFPTDEAYLYATISFFSGVIVMVHEPEAGCSVSDHEDFPAQKDECVVQGKDQKKLLRMSINTALAIGIHNFPEGLATFVATLDNPRVGAILAVAIAIHNIPEGLCIAMPIYYATGNRWRAFGWAMVSGMSEPLAALLGWAVLASCFTQTMFGALFGVVSGMMVIVSVRELLPTAHRYDPDDVVVTYSFMAGMLVMAVSLVLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6C2</accession>
    <name>B7G6C2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_48206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182548.1">
        <property type="nucleotide sequence ID" value="XM_002182512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6C2"/>
    <dbReference type="STRING" id="556484.B7G6C2"/>
    <dbReference type="PaxDb" id="2850-Phatr48206"/>
    <dbReference type="GeneID" id="7203522"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48206"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353944_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6C2"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="10">
        <location>
            <begin position="156"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="89379" checksum="A8700C44FCD0F755" modified="2009-02-10" version="1">MGIPNLLQGLKFAVKKGNIRDYSDQAVAVDASSWFHKSVYAIADHYVEVLERTGRADARSIAAATQYVNKRCHEILTYARIRKIYLVMDGARCPLKVVTNDDRERRRQENLAEARVFRQQKRPDKMYEKYKACIKVKADLAAAVAQNIASAFPGKVELVWAPYEADAQLVKLAMNGTVQAIITEDSDVLVYAATCETTVSVLFKLDRNTGSCDIISMAWLLDPTETLVNPSKANPKKASGIEQIVDAFVSRQLRDPGRGVRLFVQACILTGCDYSPNQLSGVGFVNAFKHVQSAMHKDSKDRFRHVLKMLPRKAKDHLDPVVYEELLAQSESVFYYHPVREPDGRVVFLREPDTANEHWPSLDRFNGNLSFLGEIRNASDGTMQVLHPKEHEVAFPQPSVNAPADRVCRPASSFFTKNPNTRGGKPVKVSNPYQQAEKRPRTENRAPLQPKSPNEKTTKRSRKPFSKLCASKENTDRLQQHFGSSKNDVRFVLPSFTSEGARVPPRTLFSALRKPKKVTSGAAPFQINDENNDENAICNKNPIPQNSPICVPPALPEDTRQFLKLSAEDSQRRKVSYSPQNTEGKVAVCKTFVPSPQLDSEEMYPIKNHAESKFFRDGKRYARRVTLEDSPSPDFVEEPTDHWHVVGSAHGNSLNLVSEKLAPSSFDMYDDFLSPSKDTDGENITEDLPPETTSVDRKNPLCRPLETCKPKHTLRPAKHLHFRFGGKYRSTTARSKLEKGALMKGFARQRQLATVDLSVTSVLQRAPLSPKQKKLSQFAFLNSHRYSKDERKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6P5</accession>
    <name>B7G6P5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182767.1">
        <property type="nucleotide sequence ID" value="XM_002182731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6P5"/>
    <dbReference type="PaxDb" id="2850-Phatr48308"/>
    <dbReference type="GeneID" id="7203784"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48308"/>
    <dbReference type="eggNOG" id="ENOG502SPGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373633_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6P5"/>
    <dbReference type="OrthoDB" id="47697at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855879" evidence="1">
        <location>
            <begin position="23"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="744" mass="81898" checksum="222200F8EF8B4BFD" modified="2009-02-10" version="1">MLRLTGVLFIAIGAIEKASVEGFGVVPKPLTNSCRFSHGKIQSVHFAKFKPSVPEYLVNENDEGENSGEDGLRNGAELEQHTSKTSEPLILPEPPVVVAETPHSMKGDLKPSTQFAALAPGTVVHIQVGDVSLARKAWKKRRRSGSPLLVPCSVLNVDRASTIRWNLIYILEKFGRSNASGIRMTLTELSSRHRTHLKSSLSSHAVALGYETPRDMVEALFNKKAQDEYGVKLLEANPEGKNTNENGQHLILQAPLSRFKAQKRANAAPILQFFSQQGSTVDTLQHTGVVRNRQNGVDMEAGDNLYRLQPLSAALRVSQEDVEAGTIHNGSFHAAVVFDYDMHGDGGEPLLTLSLNPARNQVRDRLKISDRKYTPLANPRYILKELTMGDGPMEGKVLRLIKGGALVDCGVGRRVNNAPYETVRVLGYLRYKDATPSSVGQSRISGTVEVYNSNHDGDMDSLDSADDLDDDEWEEILSIDHLDADIDEDQEGDQVDDVTIPEGIFDDAEDDEFTNSEDITHMFHQNEDGSLTYRDPESGETQIIELSSGNDEVEYNDETSQDDEEDQPVVFAKPGARSFGGRMIPEGLWNTTPSRLKKLHVGDRIDLYVKSVSKQSNRLMLTMNADIKGKNAKQVKHETEFNKKLSRLISQIGGLQKVGALSGKEMDGVVRALSKTGDWIYVEPSDDSLPVGVAFAPKALLADIAQGDSVRIQVEGVDEDRVLPSRLSNVYTYAGIAWAETIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G766</accession>
    <name>B7G766_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pt-separase</name>
        <name evidence="7" type="ORF">PHATRDRAFT_48451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182854.1">
        <property type="nucleotide sequence ID" value="XM_002182818.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G766"/>
    <dbReference type="PaxDb" id="2850-Phatr48451"/>
    <dbReference type="GeneID" id="7203627"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48451"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233054_0_0_1"/>
    <dbReference type="InParanoid" id="B7G766"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1827"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2039" mass="225482" checksum="FFDC27CB1F6B5FA0" modified="2009-02-10" version="1">MRNTEDAPPGVSTRRRTRRTRSIGKENSCGKTSQDIALVADDQSTKSFSQNELLKDDSGKLLLRFHSAAEDSCFRDYWEQETSLAKAVVHASWSLSLGRTIDGLILLDSKSTELLNMSRKLIKEATEAKKSNRVVGNLYVATHLLRAVGPRLTDVSKQEAAIKVLYHAIHTAEALGNLSKESSVIVGESFVCVFAAYEVLGHLLQQVCVQSDNGISIGFTFQRSENKAHFRSFPVPEKSRRSKLKVKLTLREISSIAIQATIFVSRVLRKLSFEKDNDIDLAFQAWGRLTVGQIQSGEKRLRADIIKLFQNIATRWIFAVGLYSVGYETEMLSHCKKAHLVLWDAAMMISENKDDANECLELRKHAIRVLLLNGRLRELPQRVGKYFITTVFDSACSYAWKSAVSYATKLSMSSFPVASGHPLHDFYMEASSILDTIASIESAVYGEYCAYRAIHIGQFPVKPSIECGDSCLFTILCYPCFHDTTFCSSESNDCPVTIWMALFFLALRVKSELEAMKATEDLTLTDAFYKGAGTVLEIFESTISVGLASVFVFPHQIWLKLFSMVGLHKAVHALLDRSEGICLHSSFRLLRLASDILVKCLGPLCHLVVRMDTDPAREPNILEHSDTLILSLVERLSDTNRRIKPPSSCIYKFASSLKVFGRKRFEVDKDAAIPVLLASIELKMLQWHSKDSTCDKLLLSSTWSFLASIYKSLNRNDEAIVATASALLFEILQRAENCSMPGNQLVEEAAIELAHLTGGVLSASLDSGLTLSEEGKALAARLAVMLSERTNSKTATKVGKPILAVSPETSLEMLKNAQQNEIAVEDSFIAVSKVPFTASAVMERIISGNANLFVTTTTRYCAVYLTLQVIAEVLSKIGAVIQMKAAERTTSGEHMLWEYGELASLAIKTGSELVADLDSPALPVISAILHLIASVSLVSCHQSFASGSAVSQPSKSKQNKDPELLLSSSRSHARIFAAQALESINTFENQVGEWAALSLVLLPSMTILWESMKDSSCGWHAAVLGGSESAYRMLIKATMVLKVCPNHSRVIEMARRCVLSTLSLVAASMALSGETLKASEIASWGLTLSIGQDPFAFAFLATECLTAQAETGILLNRKVFPETAVNMPGFALEKRACSARLDLTSIRKSKKELNSSRAMETMLSEVETALKNSSNMLSNHVLRWTRSTILLGLSEAAKFEGRVALSIKYLRECFQDCKQLTHTAARDSLGKRHSSSVPLQNEPFIRIFFIRCLDRQLECVIRLYWLYASLGEIQKASAYARTVLAMKTSFLPGNSFARDQSVNRLIVHAAVTGSHRAVAEQQVLQAFTDCEGTTKSMEGTSSLSLRIEKTLDALNVHELLDEIGFGFSCSEINDLQHVAAKRYTKIIRDPEIDQVIRSIGCERTEHEHLHPNIFCNLKLSLIRDLLVGGVFRTDLHRVNARDFAASILDCPGAPPDCLAHAHYFSGLVELDVARSSGALRTLWTGYSNFDPNSGGAEAYLEHLVRARNHFECALRYIGKRADLFSRRVLRSLALIAGPACSMSSIATSSHNYIVRSLGRSWRFHSSKFVPTDCKVDGGGCDSDSSQNAFKLFDSDKSVDVNSFYEELQEILPSSWNVISAVLCPSGEMLISTIQKAKSDELTIKAFCVFPEPESEKAQPLALFDILLKPFDRIMQRNQDQLDGGSPGSKEFDLTEKERKKGWWKDREELDTDLLHLLQSVDRKTFGSDFIQSFFTNNRGNTSSYVGSLASRFDAVSDDKDQISAEAKKGVPFGMSTLNECTFLVLDENLQRFPFEGLPSFENTPVSRLPCISFLYFSLKATKRALDLQRVNYVVDPESNLPGTRQRIMPILDSLSQENDREWDGIVGCEPSSLFFQKSLSMDSSLFLYFGHGGAEKYFSSKEIFQFGVDKWKTHENIGASIVLMGCSSGRLSSANQKGTKHTDDIPFFFEPGGVAISYLAAGAPCVVGNLWDVTDRDIDRFSTDLIGTLFKGPGSPSLVSCVCSSRAACRMQHIVGCAPVCYGIPVPVLEHTDLRDHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7D3</accession>
    <name>B7G7D3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_15214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183254.1">
        <property type="nucleotide sequence ID" value="XM_002183218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7D3"/>
    <dbReference type="STRING" id="556484.B7G7D3"/>
    <dbReference type="PaxDb" id="2850-Phatr15214"/>
    <dbReference type="GeneID" id="7194866"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15214"/>
    <dbReference type="eggNOG" id="ENOG502R8YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_0_1"/>
    <dbReference type="InParanoid" id="B7G7D3"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="111" mass="12072" checksum="3677DC7E089DBFA1" modified="2009-02-10" version="1" fragment="single">MSLSIAVPNEYGYVVLTSVVGGFVTSTILGGFVMKARAQYQVPYPNLYATPGFHKQADAFNRVQRGHQCFFETYSVFALMALIGGLKHPIISAGSAVLYHVGSFLFLKGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7F8</accession>
    <name>B7G7F8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypotheticalal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_15217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183139.1">
        <property type="nucleotide sequence ID" value="XM_002183103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7F8"/>
    <dbReference type="SMR" id="B7G7F8"/>
    <dbReference type="STRING" id="556484.B7G7F8"/>
    <dbReference type="PaxDb" id="2850-Phatr15217"/>
    <dbReference type="GeneID" id="7194930"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15217"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319231_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7F8"/>
    <dbReference type="OrthoDB" id="193370at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF178">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="94" mass="10336" checksum="CC8E41FCCFD005A8" modified="2009-02-10" version="1" fragment="single">MASLCDVLLPMCPLNKHTTHVIDAKVLNRLRPDAGLINMARGKVVDTDALTAALQEGKIQYAILDTTFPEPLPTNHPLWSISNCFILPHFATNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7G6</accession>
    <name>B7G7G6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183143.1">
        <property type="nucleotide sequence ID" value="XM_002183107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7G6"/>
    <dbReference type="PaxDb" id="2850-Phatr48709"/>
    <dbReference type="GeneID" id="7194934"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48709"/>
    <dbReference type="eggNOG" id="ENOG502QZDX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503891_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7G6"/>
    <dbReference type="OrthoDB" id="49448at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="638" mass="71423" checksum="17559CE3E44944C5" modified="2009-02-10" version="1">MTDNSNKMPTDETLGRAQMDAEKRGKDIESDSRIAKKNQVSKDSQSTYASAAVPAVAAKWIVRILELEGRPELEKILQSDFGLRCCTVRQIKHVWKCLLHCCFSFVVSRLGLHGQPTGRKDVCMAKLRRYFYDDSDCTVVFTLGMIALQHDLERESSAANIILPPSFPMPQVPRHSKRKAILPAPCTPSSLPTRCAPSSCHPLHNTQNTTSCRPWQQGFTTLSTSANARKDVAVYQKRIIEDTSSTYLPQRKRVKCEPKSEIGASYETQPRNSLEANLMMQLCQIGFSNKHEVLSCIRRIASNSTDDPPNIDSVMITLVTQREEADEARKIDKARLLSEQSRKAEARRCRLEIQQQEDERMLNCNLSVLSSNPAMFPQSWILKSRAYNQILLATQSDQKTKGVLLELLKLEKRARTWYNYTLPKAYFGIVVPQRLLQASSLTNQLRTEVATLKAAMFKLSEQTKGGVPRILLEAHENYQYEMKSVGNEALDEIEVLGKKLPSMPSQGGSSGTDYSNHEVIEILNLNTNITNDGIKDKDGTAEGTNNGIEDKDGTAEGSDDGIDDKDGTVEGTNNGIKDKDETAEGTNGPDDKVKSISYSFLNVRYPVLVIVKKPWMTLAWCLHNPQEPGKHPEQKQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7X1</accession>
    <name>B7G7X1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183090.1">
        <property type="nucleotide sequence ID" value="XM_002183054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7X1"/>
    <dbReference type="PaxDb" id="2850-Phatr48622"/>
    <dbReference type="GeneID" id="7194829"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48622"/>
    <dbReference type="eggNOG" id="ENOG502SNY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556066_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7X1"/>
    <dbReference type="OrthoDB" id="42209at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55112" checksum="C5F7ACB4051B5962" modified="2009-02-10" version="1">MPVPAAPTMPRSARLNGRNRGTSRSLISSFAGRGLLLKVVGFLAILLAFYQTLWVYWLAGVNIPDVEIDKLTGQKRIRRRPDKLRKRDHIARKDVPTDFLDGIMEGFHTLVSIKVPKKGLVSTAEKAYTGVGATFCHVSWHLQERDPSKVPMFKDLREQSMMCQGTLHTVDLYEITRKAFAYDSRNHTFAATPPKPGQGPVPPTAVVFHESRCGSTLIANVLGASTYSQSRVYSESPPPVAALKACEGEGTTCNVGAQSALIQDVFYLMGRTTRPIQPQHVFYKIQSVGVKSIEAFAKAMPNTPWVFAYRDSIEVMMSHFKNYQRGNPLSQNFLPVCLRSYGEPNQPALLKEIVEAKERTVESLSHEEYCAVHLASLCESAIREYDRAKSLPNAPPRWFLNYNELPYDVWEHVLPPLIGTLSDSQMARMQDVAKFYSKGRGPRAGQHWHEDTTVKQGMAPESVKTAIRVFLEPSYQRLEEIRAELEAQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7X8</accession>
    <name>B7G7X8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183094.1">
        <property type="nucleotide sequence ID" value="XM_002183058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7X8"/>
    <dbReference type="PaxDb" id="2850-Phatr48628"/>
    <dbReference type="GeneID" id="7194886"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48628"/>
    <dbReference type="eggNOG" id="ENOG502SHJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_922847_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7X8"/>
    <dbReference type="OrthoDB" id="40121at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="285" mass="31639" checksum="035827BA95AC402C" modified="2009-02-10" version="1">MSDRPKGPLGIDPLRFSIVLFVFLFLFVIYLLLPRALRKQYFGAYPKRHAWSARSRARRSGAVYGQSTIGDNTGSYTGGSSLGTGTTTGSHRAMHMVGLAATAPHRAEEEHIDFTTPPHDAQQNNDEIVISAAMQQLRDPGVLIVAHGSRGKPKTVRLQLTEMAITWRTETRKKKDVKPKMGKLHQVPLSHIMYVDVGKQTTALRRVENASVSEALCFSLLTKEGSLDLEANSPRERDALVSCFSLVLDEVHAQNWRDIYRGPSSDMPSSFDEMDRAQAGIYNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G847</accession>
    <name>B7G847_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183276.1">
        <property type="nucleotide sequence ID" value="XM_002183240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G847"/>
    <dbReference type="PaxDb" id="2850-Phatr39252"/>
    <dbReference type="GeneID" id="7195188"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39252"/>
    <dbReference type="InParanoid" id="B7G847"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725">
        <property type="entry name" value="OS03G0364000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="101" mass="11111" checksum="DF6F12420CC0838D" modified="2009-02-10" version="1">MSSTKLYLRVERRNQTFCLLCETSDTIASLKTQLALAASQHSTDGVDADQMRLLLDTTVLEDDSTIAGLELKDDAVLYLVYAVADNEYESVDVVSTAFQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G895</accession>
    <name>B7G895_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183303.1">
        <property type="nucleotide sequence ID" value="XM_002183267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G895"/>
    <dbReference type="STRING" id="556484.B7G895"/>
    <dbReference type="PaxDb" id="2850-Phatr48756"/>
    <dbReference type="GeneID" id="7195010"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48756"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682353_0_0_1"/>
    <dbReference type="InParanoid" id="B7G895"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855886" description="Pseudouridine synthase RsuA/RluA-like domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="383" mass="42384" checksum="DB30E9A7C8D68025" modified="2009-02-10" version="1">MIHSGTFPFGNCVVWVFLTLVSVLRLGSGCHAAWTSPARRRRGRTTTGPDVKDRTVRAVTVANTPYLFGTTPRYCIDNSDSPPLEVPGAPHDDVDVPVLFQDDQILVVHKPSGVAHHNDADTGRLGILNLIRHQQTTGRFAYPHRLYGVHRLDRVTSGILVLAKTPGAAQILTQAWREDRVTKYYVGLSGNKATTSKQGHVRGRMIRGRRRSWLLTRETHGSNVAHTRFFTAGLGHLAPPSSTLTNVSPKTLLLFRPTTGRTHQLRVAAKSVGLPLWGDPVYRDGRHRTENASTPSRTLLHAAGWHVPADDTHPEWTLWCPPPPEFDVWANPDARDTENPACFDSVLHRLLHKHVDCEPLLYAIDAAASLGTTRVGLLHPDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8L1</accession>
    <name>B7G8L1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183361.1">
        <property type="nucleotide sequence ID" value="XM_002183325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8L1"/>
    <dbReference type="PaxDb" id="2850-Phatr48852"/>
    <dbReference type="GeneID" id="7194939"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48852"/>
    <dbReference type="eggNOG" id="ENOG502SNHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443779_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8L1"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474:SF1">
        <property type="entry name" value="2'-5' RNA LIGASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474">
        <property type="entry name" value="RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855557" evidence="2">
        <location>
            <begin position="23"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="602" mass="67992" checksum="083A6EB8E6C67556" modified="2009-02-10" version="1">MRVRRGLRCLSAFVVWFDGTSAWRLSPPRPTRKRPRRDPDAVPPPVKRDVSPPRRPSPTARPPPPLRMTTALGIVPPDPLWDTIQRARHFARDSSYTKWPPCIRLFHPFSQTLALQVARVIEKYGVEPFDITLNAWSVVPHLEAMEADWLAMQKLPAQVSLEDDRRSKERAEVDDLIAREVEVGKEKLQQRQQRKANQSSNSNSNHTNSDATNIDTNTAIKHAPHIGRDSDTLRKDSTEESSNVTDDDDDGHPHQNLDRRDKSAPAASSPRAMLDRQKRMYEEFNGPCIVCLEPDQESKERLIELRHLLCQELGMDPAFSPSSANADLDTRLPKAAKESEFRPILPIASFTSVNAAIDMARKLRGLWDPLTFTVSDFQVISCEAGGELDEFGDNAMRTPTRPRPDPYAENREYQLRKTSFLSHVQDQERNLTPDGQFGCDALIMFLGEEPEEDERARQKRKPDVQVMNSDGCESEDEMIMDDNKGSRGLELWLSEDDDFDEGTAVAVGRTLFFTGETREFVGMPATSVVDAKDRILGDGVSGAARRRSTVHRSGSLWEDGEWGRKEVDSLPWSKMERGAMTRAQEEYAKDDDNDDALSDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8N1</accession>
    <name>B7G8N1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183499.1">
        <property type="nucleotide sequence ID" value="XM_002183463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8N1"/>
    <dbReference type="PaxDb" id="2850-Phatr39438"/>
    <dbReference type="GeneID" id="7194951"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39438"/>
    <dbReference type="HOGENOM" id="CLU_951446_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8N1"/>
    <dbReference type="OrthoDB" id="204836at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053234">
        <property type="entry name" value="RPM1_Interactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33443:SF30">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-2C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33443">
        <property type="entry name" value="ZGC:112980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="32459" checksum="0C13B709549383D5" modified="2009-02-10" version="1">MSTSKRSLPTSTVDSIAQKKAKSSPPSTVHSSCDELDTEEEDSLPEFSQTAFRILPTTRTRPSDGTQSPLRVSTPTPLLPSSPADSEVQVLSPSLFRRPVALTPSGNGLSSRRTRAEMNDFDSDEIVLMGTIRVTDTLPHMRPHCSMYPLSIDPEQFCKFCYCYICDDLATNCKMWEGGHCFATDQGSDATYWWSLRYDRKKQRHKLGGVTSRQAKVTAHTATVSTRRVTTTSPPENVHFQRKRQAVMLLDQSIAHDGVLASTLSSPNVVHWIGFLCVGVLGLLLLPTRDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G989</accession>
    <name>B7G989_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183729.1">
        <property type="nucleotide sequence ID" value="XM_002183693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G989"/>
    <dbReference type="STRING" id="556484.B7G989"/>
    <dbReference type="PaxDb" id="2850-Phatr49027"/>
    <dbReference type="GeneID" id="7195410"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49027"/>
    <dbReference type="eggNOG" id="ENOG502QQ1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325568_0_0_1"/>
    <dbReference type="InParanoid" id="B7G989"/>
    <dbReference type="OrthoDB" id="416832at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756:SF3">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855965" evidence="5">
        <location>
            <begin position="26"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="411" mass="45625" checksum="D0581408E63C1E24" modified="2009-02-10" version="1">MFRSSRRMELLGLGLLLVWSSFGSAFVPVSRTVKQNARLTLASLATRATKTVLFGAPANSTSADDEELIRLIRGPLGAKTPRPKPKTIIILSDQTGVTAKSAVGKSLEQFNGCDQRFINLREEDETESSLQSVDERDDDEDCINVGTRVYPFLKTDSQIASVLKAAHDKDVIVVFTLADPELRDATIRMCELSQVEYVDLLGPMFSSMTSFFGRAPLGKVTQMPSSPYTKAGKIIKRRKLSDDYYRRIDAVEFTLKCDDGMKPRLLKEADVILLGVSRTGKTPLSVVLAQTMGLKVANIPLVVDLPPPVQLFSDDIDPQRVFLLTLDEQDLMRIRRYRLNRELKHASTVGASSSSYADPDYLQADLAHARDLARKQGYTVIDVTGRAVEETASLIQSYLNDRFPELTQQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9H5</accession>
    <name>B7G9H5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183773.1">
        <property type="nucleotide sequence ID" value="XM_002183737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9H5"/>
    <dbReference type="PaxDb" id="2850-Phatr49099"/>
    <dbReference type="GeneID" id="7195452"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49099"/>
    <dbReference type="HOGENOM" id="CLU_546878_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9H5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="499" mass="54159" checksum="4CC78DF7EA1452F0" modified="2009-02-10" version="1">MEGKLPRERLSEHKRSVLTNDAVIKQGKQSSLQEVIEWRGRASNVASATHSNDSSSHHDTSNKSKSRPSEVDDEKASGSAGIVKTGAIASSDEMAFQKAQESSKKMAARLPTDQKRPSMSDLSSASSIPVSTEQTDVKKRKKRRSRGWTFNDVESATERSNKNIKITKAGPFRDHKDNADKRGNFEDVDGKLISYDQASTGSLAVEGRLAKNSGLRREDAKAAEKREYNRVNAARARLRNKEMVEELQKNVIDLNAHIVELERSNEILRAQVEVLGSRSQSLLTTSQVPTAAAPEQELDHVQSSTAAIVAPSFNTPIFSVQQSGTGTGQPSPHQNVVAVEQLLASILGRSLPQLEQPPSPPALDNLSLLLTLVQGSNGASINSQLQSGPPQFSGAAIAPPTAQPLPSTLFAMNPSLHQQQQTIHSRARLLNMQQPFDPYAHLSSANLQSVLQNLPAGTLYAALQQQRQLQQGDGPGYPIDDSLRNKNDNKSSSLGKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9N7</accession>
    <name>B7G9N7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183924.1">
        <property type="nucleotide sequence ID" value="XM_002183888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9N7"/>
    <dbReference type="PaxDb" id="2850-Phatr39807"/>
    <dbReference type="GeneID" id="7195616"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39807"/>
    <dbReference type="HOGENOM" id="CLU_2255426_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9N7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855980" evidence="2">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="104" mass="11355" checksum="9A29ADCC98C7364C" modified="2009-02-10" version="1">MLRITLIIFVLLGGVDAFQSGTPLPARIVHPGVTTGRTLPTGDPHPALTSSTGLAAIRPPNKKVITEEEKEASTSIGRLLSPLNPYMWFVYMFVFIFAADFVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9Y1</accession>
    <name>B7G9Y1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183969.1">
        <property type="nucleotide sequence ID" value="XM_002183933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9Y1"/>
    <dbReference type="PaxDb" id="2850-Phatr49238"/>
    <dbReference type="GeneID" id="7195701"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49238"/>
    <dbReference type="eggNOG" id="ENOG502S9KF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101194_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9Y1"/>
    <dbReference type="OrthoDB" id="185375at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855605" description="HD domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26878" checksum="992FA75ED69F3685" modified="2009-02-10" version="1">MAAISFGSILLLLLSLSLAQLLRWNPMWFGRSAGELPSSSEFFVFHEHDTLDDALFQHVGQLGDEFDAYRNHCLRVLSFAVHHLGGLRNVTNRQVNLMALALAYHDIALWTDGKLDYLDPSAALLLRDLRKNDKSGSVQDLQDADFVTLREIVLQHHKLTTWTPPEGSQADELLVNAVRKGDWADATIGMIRFGLPAAYLEKAYTELPEGGFHRILARMGGRLSPDSITERLAVLNIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA10</accession>
    <name>B7GA10_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_23079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183987.1">
        <property type="nucleotide sequence ID" value="XM_002183951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA10"/>
    <dbReference type="FunCoup" id="B7GA10">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GA10"/>
    <dbReference type="PaxDb" id="2850-Phatr23079"/>
    <dbReference type="GeneID" id="7195559"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23079"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA10"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="259" mass="28619" checksum="2F5DF1DA75ADFFC7" modified="2009-02-10" version="1">MAPKKGTKKGDAKPKKAVADPLFPSRPRNFGIGNDIRPAGRDLSRFVRWPRYVRIQRQRAVLYQRLKVPPAVNQFTKVIGKNEAMTVFTLLNKYRPETPAAKKQRIKEAAAAGGKDAGSKAPHQVKYGLKHITTLVEEKKAQLVLIANDVDPLELVMWLPALCRKMGVPFMIVKDKARLGALVHMKTAAAVALTGVDKADEKQLELLKSLGTEKYNDNPELLRKWGGGKMGLKTQAKLDKRAKAVAIEEAKKLASLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA88</accession>
    <name>B7GA88_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPPC8 first Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184028.1">
        <property type="nucleotide sequence ID" value="XM_002183992.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GA88"/>
    <dbReference type="PaxDb" id="2850-Phatr49332"/>
    <dbReference type="GeneID" id="7195492"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49332"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230072_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA88"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1779" mass="197774" checksum="848723A829DC228D" modified="2009-02-10" version="1">MRQPMSRNICGSLGNGEPTRNGRAKGKIDRHTPRLSRFGCWRSNAGKGLVFFRLYRSLGLIQNRETDRGMSSNKTDQSSGRSQQQQTTKNSLPFRMPETRQSKTSQPKSPPRSGVPFPPHQSLAEIPTLASAPPSGNVNFDDLYDREEPEELPQDRIPSIAASSSFTTPTLASLPPPPPRPPALATMRPGTNADAPSAATLTSAQLSLPPPPPPPRQSAKPTMAPLPPPPVMHSKPIKPALKPTLDTQSPSRVSSKPHEAAILLDVKQASSDPSETNFRRTPKEPERLPSTAFRSKSLHVLALRQSHIPIVVITTETANIVAWKNELRLEDMLNGLIQSVTSGSSTPNASTQSASPTLAPFRSVTRSLTLHWDDLQVRFQHASSLDVTLSLQDAQVALQAACQLSPEDGNLEQELNLLEDKVDNLLQQDHDEDVKDIMDVTAARQRSMDQATKDAFGLTSPLTIPWLWRYRQALDEATNGLEHDLIACPPLILYVCSTQEVTNPIETLQNLKSSHYLPSCYHDGRYDPAGVRQEVLVLHDNVDGPQNWDESELRSSLQKAFGPGASVVRVNSIPMETADQLAREETSDVWNGRGRRGNCLSLSDRVALRYYLANLLTSSLLPALERRIATLNGIVSDRKKGVRNVLKSFWRSGKADEEAAVTKSVQVASTVAYRYDTVESQSRLLADTLFLMKDYEAALSTYRLIKDDFKQDKAHVHYASIQEMMALCLYYMDPYTRAREIFSHAENALLGYSRAGQEERSMAWGEKPGRPTMATPSTRLATRLCLVLTATRHVCTGRHLEVADLLASASSSETALGAAVLLEQSSAHYFHARLFRKYAFHMLMSGHMFRAAQQDHHAFRCFVSALYIYRDGRWEELHSHLRSALAAQLFSMGRMALSLQLYAKIVGSTGGGRVSVKSQQKYINHLLEICSEHTKKALVGADRMAASSKFSGAELDAVRKNRLDRIVQVVRYTKSASRVLELPNIDLPLVDDTTVKLITEEASEMHDDPLSIFGQVRRGSEEVWAELALSATAELRAVDISKSKESDEMVSKRVAKIHDADVRAVIAQIDKEKANLTMKERSKRSHSHTEESPTRALKEPITVEFEMTNPLGIPIDLNDLQLVARMTDEDGNRVCTSEDAIKITPLVSSNEKQRWSFNKTAIEYNVADFCRMSLNGRSTEKQRWKSAEEVEPFFVVTKTSLTLEAGAKLTVAARICPLVRGSLEIIGIRCRLFDEVWIFHHFILKGPLLQNTRQNRVNRIRAESLLLKARIEGGMPCLRAELISTLSSSGAPALQGQISRWNLRLSNVGTAAASSVFMKTNMPWVSINLGARRQVDSGDELKSLCVGPTGTLMELPIRGDELNCEGQIQPGEIIEVPIDIRTSGAGRQEFYVLFRYMLADEDGSTTTKHRWLRKMFEVPVYPSLTLAAKVAPSHLTPGESILSVELTNNRSDRPDKLTIRLKKLTLASPLYRLEPIHGQLTKEGDENSEPVLDWQERISLHYRIMASSQVSKTCLLSEYLLSAGSDQDSRSTLTDATTSSSSLDFLCLERTFEAFEETWRSHQKDVARASVVQDREDLHPRSIAQIRRANTGALSDYGAESFAEKLEDKREHPASIARLFSLDKSDQMVHLLCSWTSEDGLVCGQHNIRQLAVRQTLTTKLCPITVTAEYPSHILNDFSNGPASIPVEIMMENTATDGTIDFEFNLLATTDIDFTGLQMFKYCLTKGERVSVSLQALISSTGVHNLQRIRLIVKSNDVSVPYLLSSQWIVHVTGIGIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAG3</accession>
    <name>B7GAG3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184193.1">
        <property type="nucleotide sequence ID" value="XM_002184157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAG3"/>
    <dbReference type="STRING" id="556484.B7GAG3"/>
    <dbReference type="PaxDb" id="2850-Phatr49396"/>
    <dbReference type="GeneID" id="7195895"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49396"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090841_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAG3"/>
    <dbReference type="OMA" id="HASYDER"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="161"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="29425" checksum="90F1DE8EEF0C4392" modified="2009-02-10" version="1">MSRAPGLGRALQTLRVGSLPPTAIRTATATRSSSSSPLVELREYALKPEFSTPYLYATGTAADLRKSLSPLRFFSMPDTGGELNKATHAYYYQGGHEERNAKRAAMATNAEWKAYLESCRPCMNSQSSLLFVEAPLVGQMDQVLGLADEPQSDNGNDTILEIRRYKLKLGYDTVPKFLNLFAQGLPSKLNADGTDPTTSLVTLLYCEVGRLNEVIEIWRHGDGSAAMEQSRVAARNAHEWREAIASIADLAIEFSSTIHKPAPFSPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAT9</accession>
    <name>B7GAT9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184135.1">
        <property type="nucleotide sequence ID" value="XM_002184099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAT9"/>
    <dbReference type="PaxDb" id="2850-Phatr49501"/>
    <dbReference type="GeneID" id="7195842"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49501"/>
    <dbReference type="HOGENOM" id="CLU_060859_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAT9"/>
    <dbReference type="OrthoDB" id="44477at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="49928" checksum="C50AD65E9464479A" modified="2009-02-10" version="1">MHIGHITIEYSNKTIAFCFVSATKSRSSATSHCSRMIVRLRSGRSVGNVQILSVIAIAFLSFSQMYVSINDAAFFPETFVGRESTVLKTPIGIDEIERATRRFFENSTERTALEPAPRPSIEDLADGPKVTGDVAWLLQFALLGFPKCGTSFMMRYLGQHDEIAMLRDKEHCELTTGTKDSVLVKALLDGLPIGNYARGLKCPKHLERPLAMDRLFRYFPNVRVIVGVRHPVLWFESFYNYRHLEGHHLLPAQELIGNCWNLGPTEKVRSVCTERAKFHNHLARLGKTSMQSAEERQHFSADVQNVSYAHGFSSTKVFLYDMAQLEDKNQDRSDILLEDLRSFLRVTKPFPPMVEEPKAVSNATRIDICDVEYDHLREVLLDTGVKASRWIRRFFVHAEGVTVSSPDFLDQLLAKWEEDPCEERRAKSNASLSRPDRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC64</accession>
    <name>B7GC64_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184664.1">
        <property type="nucleotide sequence ID" value="XM_002184628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC64"/>
    <dbReference type="PaxDb" id="2850-Phatr49878"/>
    <dbReference type="GeneID" id="7198594"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49878"/>
    <dbReference type="HOGENOM" id="CLU_503893_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC64"/>
    <dbReference type="OrthoDB" id="10681986at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853106" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC43723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="533" mass="57518" checksum="36C54CB1A8BB23AD" modified="2009-02-10" version="1">MKDRAMPSFRLPLLMLLSLYFPMDILSKTDLSSCMEAMQLADQNRDGLISRSEYVNLMTTLSPYESCPDSRLGGDLLGNGSFHLAFSSLACLCLRYTNDRNCCTEAGEENGTGPVLVLGNVYPKAYTERVCATLAGTLDDECAPPPTLSPAVLLLETPVTAAAAPTAGRPEASQPPTVSPNFRPSSNPTAPPRESILPTPTSLFNSGGVEDGGNNGSLVDANTDDPNRGLTIALPIVLLLTLIGTLAFWANRRRSRARDREFSSLALGYWNKGRGTGGEQPSPSDNFDNRTTCTKSIETPGCVWVSELKLPLSLEMHTPQRSVNLQNSFEMNHRGIDAKTQVSLGSLGVYESGSETSTGVVVVGELAHPKIRRDREFSSPLESEGSEIDEEFLSEQDVDEISSLATTSDDYDCDSNYTLYRACDAVPEKNQNDSYTPGDKAKQTPPPHGVSRQRRPSAIPTVGIATSPIVLVNTTLHAAATEYPDQGPTPAFQYAEEGNDSDSQADFSFLDYSLKQAAWLDFQPGAAPEEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCW2</accession>
    <name>B7GCW2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_40956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184870.1">
        <property type="nucleotide sequence ID" value="XM_002184834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCW2"/>
    <dbReference type="FunCoup" id="B7GCW2">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCW2"/>
    <dbReference type="PaxDb" id="2850-Phatr40956"/>
    <dbReference type="GeneID" id="7198765"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40956"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="B7GCW2"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="529" mass="56674" checksum="E474954D1F06A615" modified="2009-02-10" version="1">MDDDPTAGSVTLRNIEACMQLSRMLRTSLGPQGRCKLVVNHLERLIVTSDCASILKEVTIEHPAAQLLAEACQKQETERGDNTNFVLAFGGEILWQTSQLIAKMTWQPAPEILAGYQRALTLVENKLLPDLVCDGVTDLKDKHQLLKILQPVLASKQYGSEQTLAPIVADACLTVMDAQGKFNAESVRVCKIPGSSVSQSTLLEGYVAMRGLETVVTNATDAKIAVYACGFEASSTEAKGTVLMKTAADLLSYNRTEEAKMEEIVQGIAASGVKVVVTGGNLSDMALHFLDRASLICLRIGSKWELRRLCQAVNATALVRLGAPTPDEMGFCESIRTQELGGKTVTVFRSHETKLATILLRASTSSVLNDLERAVDDGVQAVVQAGKDGRLVYGGGAVEMALSMALQQEASRVPGLEQYSIAAFGKALEIVPRTLAENAGWDAVRVLADLKASHAQHGTESVCDVGIDIERYGTENDDTGGTCSMKERGVLDLMSTKLAALRLAVDAATTILKIDQIIMSKPAGGPKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCX2</accession>
    <name>B7GCX2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_50096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185027.1">
        <property type="nucleotide sequence ID" value="XM_002184991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCX2"/>
    <dbReference type="PaxDb" id="2850-Phatr50096"/>
    <dbReference type="GeneID" id="7198886"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50096"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_8_1"/>
    <dbReference type="InParanoid" id="B7GCX2"/>
    <dbReference type="OMA" id="AWMGPSG"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="640" mass="70537" checksum="FA32AC8E1951FB31" modified="2009-02-10" version="1">MPTCTEDPSKEPEPIKLSALSNVSAGRQVPLVELSLQNVTYAPLTTKASSNGKTSGRKRTTVLQNITTTISPYKLTAWMGPSGSGKTSLISIAADLTKSGDLVEGSIITVNGEEGKIPKRIVGVVWQDDLLLTNLTVEENIYYSARLKTPESCSDEQVSAVVLETMIELGLTDIRNSVVGSPLGVVRGVSGGERKRVSVASELVVRPSLLLLDEPTSGLDATTAQALIGTLKVLSNMGHSIAVVIHQPRTTIYNMFDHLLLLSQGSTVFNGNPSKAREYLESCPIVGELPPETGLADWIMDVIKEDEQRREAAMLASHWAEYINKESVHSMISDSLRKTLSRSMSSLHELHAVPKFNNSFRTQLKLLTSRTMKQQRGERLTMTAVILQLLYLFFSAVLWWRLPNNTARTFERNSLLFFMIIAQANGIVISAVTVFQRERALLKRERAKKMYGVSSYFLGKTASDMTNNVLLPVLYGLVVYWTAGFRPTFEAYLKFFVAFYLTLSTAQSMGLWMSIAIPNMQVALVLAPPITLFFMIMGGFYIPLQNMNRGIAWASWISFARYGYSALIINEYAGRDIPCLDDGEASIAIGTGVCPLPGEEVIASLGITGVAESYWFNIGMTVGLQVMFRVAAYIFLRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCZ5</accession>
    <name>B7GCZ5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184962.1">
        <property type="nucleotide sequence ID" value="XM_002184926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCZ5"/>
    <dbReference type="PaxDb" id="2850-Phatr50112"/>
    <dbReference type="GeneID" id="7198825"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50112"/>
    <dbReference type="HOGENOM" id="CLU_664760_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCZ5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="414" mass="46261" checksum="97776BBF24E58B26" modified="2009-02-10" version="1">MSHSEAANDLDGRIRAESKGTTLSLKRKAPPERRVGSTAPDKHDRRIYATAASPGLLAVFSADDSIHNDYRSRSYSEPIKAKLEVDQSLLFSPSSAANYDELRERKRSATNSRKAAATARQTLDKGTQGRENLYMRRDPPSVGTESVSVHGNSSTEEDDVDRQHILKPKPRSPADKARSQRRRLRKTAGAEVRRRKIRTLPSNPLEFEGDYKTQFAPEDGTGKPLTATSLLYVMNVMEKESSEAVKAVTKGFSRDESRRIRQSTTKHSQAILKSTRLFLRSAKVSTVYTGAEDPMGSGLAQANKTRKADIERSNRILQQLESQQDVLEAELAEYVEKQSQLEETLRALQASQERAHPLLIPALAPVAEENAWNEGFPARRFRPAPRGCMPQLLEKLGDEEWRSRGSALNTNNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD11</accession>
    <name>B7GD11_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184968.1">
        <property type="nucleotide sequence ID" value="XM_002184932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD11"/>
    <dbReference type="STRING" id="556484.B7GD11"/>
    <dbReference type="PaxDb" id="2850-Phatr41003"/>
    <dbReference type="GeneID" id="7198924"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41003"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738664_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD11"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28396" checksum="E057F6932A0CCF7A" modified="2009-02-10" version="1">MSSLAATQADGYYVPPEYFESGAYQKKSKNQWHAATASRGKAKSNQSQPVVRFELPHSGVCEACDARIMRGTRYNATKIATDEFYFSTRIWEFRIQCRADCTQQFVIRTDPAARDFKYVSGIRLRVQTWDTVEAGSLGVVDLAQSGPRAHALESAAIASDLERLEVAQLGARRAQTEVEQLMTLQRLNLNIYRNDADRNAQIRRGFRTERQSRKRQLVNGDALGWRRGMSLLDHNSADEGQAKAHPLRNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDS0</accession>
    <name>CSK_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chloroplast sensor kinase, chloroplastic</fullName>
            <ecNumber>2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CSK</name>
        <name evidence="8" type="ORF">PHATRDRAFT_41268</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Plant J." volume="81" first="519" last="528">
            <title>Plastid proteome prediction for diatoms and other algae with secondary plastids of the red lineage.</title>
            <authorList>
                <person name="Gruber A."/>
                <person name="Rocap G."/>
                <person name="Kroth P.G."/>
                <person name="Armbrust E.V."/>
                <person name="Mock T."/>
            </authorList>
            <dbReference type="PubMed" id="25438865"/>
            <dbReference type="DOI" id="10.1111/tpj.12734"/>
        </citation>
        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
        <scope>TRANSIT PEPTIDE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Commun. Biol." volume="3" first="13" last="13">
            <title>An evolutionarily conserved iron-sulfur cluster underlies redox sensory function of the Chloroplast Sensor Kinase.</title>
            <authorList>
                <person name="Ibrahim I.M."/>
                <person name="Wu H."/>
                <person name="Ezhov R."/>
                <person name="Kayanja G.E."/>
                <person name="Zakharov S.D."/>
                <person name="Du Y."/>
                <person name="Tao W.A."/>
                <person name="Pushkar Y."/>
                <person name="Cramer W.A."/>
                <person name="Puthiyaveetil S."/>
            </authorList>
            <dbReference type="PubMed" id="31925322"/>
            <dbReference type="DOI" id="10.1038/s42003-019-0728-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>COFACTOR</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Sensor kinase that senses the plastoquinone (PQ) redox state involved in stoichiometry adjustment of both photosystems (e.g. long-term adaptation via transcriptional regulation of reaction center genes of photosystems I and II) and state transitions (e.g. short-term adaptation involving reversible post-translational phosphorylation of light-harvesting complex II, LHC II), thus linking photosynthesis with gene expression in chloroplasts (By similarity). Reduced PQ suppresses its autophosphorylation activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="4">The 3Fe-4S cluster is redox-responsive, probably binds 1 cluster per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Plastid</location>
            <location evidence="6">Chloroplast stroma</location>
        </subcellularLocation>
        <text evidence="6">In this organism the plastid is the result of a secondary endosymbiosis event, and is found within the endomembrane system, necessitating a complex targeting process.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Autophosphorylates, possibly on His-292.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">Probably has a bipartite transit peptide. The signal to cross the ER endomembrane system is probably residues 1-31 while the transit peptide is probably residues 32-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroplast sensor kinase protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EEC43310" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3"/>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43310.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185178.1">
        <property type="nucleotide sequence ID" value="XM_002185142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDS0"/>
    <dbReference type="STRING" id="556484.B7GDS0"/>
    <dbReference type="PaxDb" id="2850-Phatr41268"/>
    <dbReference type="EnsemblProtists" id="Phatr3_J41268.t1">
        <property type="protein sequence ID" value="Phatr3_J41268.p1"/>
        <property type="gene ID" value="Phatr3_J41268"/>
    </dbReference>
    <dbReference type="GeneID" id="7198991"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41268"/>
    <dbReference type="eggNOG" id="ENOG502S572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493029_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDS0"/>
    <dbReference type="OrthoDB" id="43364at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050428">
        <property type="entry name" value="TCS_sensor_his_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45436:SF5">
        <property type="entry name" value="SENSOR HISTIDINE KINASE TRCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45436">
        <property type="entry name" value="SENSOR HISTIDINE KINASE YKOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0003">3Fe-4S</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Chloroplast" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000453139" description="Chloroplast sensor kinase, chloroplastic">
        <location>
            <begin position="51"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="447"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="GAF" evidence="7">
        <location>
            <begin position="97"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="F4HVG8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="31925322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="31925322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="25438865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="31925322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="583" mass="63168" checksum="79DD1F452F113BE8" modified="2021-06-02" version="2" precursor="true">MSSIYLHGLSRRRRIGSVIVAIYMLDSCGAFLSASGSGRYPGFSYRGLSVVTENIRSIHSSRRLKLTVNATNKEMYERQDSIHTLPLSPIPVMPSQLFQELALSQLELLANSIPCADRPGVSKIKTMALYLPQENVNTGQLEFLPAIHYPHPSRERVFIANEAASGVAPALPRTLTTLPGFAHATSLLPGYPMVSGGSEASVGVVEEVICDLTSGAAALSVPLFSGSRTVGVLLVSPSISKRRKGSAWTKEDREQVGRAGKSLSLALSMDTERAALQMQNDRAARALSDSLHQIKNPLQAMRTYGKLLQRRIADLGLLSNEGMTPQLLEMAEHLLVQSDRLADRLKPVDTIVDSLSERTPFVLNPAAPTKTQDSLVSLATPLVPWESETLEFARESKTSGELVIFMPTKKVAASGSNGPSNSTTSFSGNGSDVSTYTEDDGAGEMPSSLFSEMDLEMSFLSDVLDPVLAAFRAIAEDRGIMFSHDDTEDLPGVTICPQALQEALINVIDNAFTYVFLPKPGSRFGPNPSAEVRIRLVQNSKGSDAGVTILVEDNGPGIPAETRDQIFDRGKDQALDWTLRKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDV1</accession>
    <name>B7GDV1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SQD2</name>
        <name evidence="5" type="ORF">PHATRDRAFT_50356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185276.1">
        <property type="nucleotide sequence ID" value="XM_002185240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDV1"/>
    <dbReference type="SMR" id="B7GDV1"/>
    <dbReference type="STRING" id="556484.B7GDV1"/>
    <dbReference type="PaxDb" id="2850-Phatr50356"/>
    <dbReference type="GeneID" id="7199140"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50356"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458917_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDV1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853258" evidence="2">
        <location>
            <begin position="25"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="271"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="507" mass="56407" checksum="500E78F3859689ED" modified="2009-02-10" version="1">MIVVKSALLIVCLVATACIGFVSCFQPYTSAIPPPCTSSVSSSSVRLEAAARSSDAPPLRRNPPRKICLMVEPTPFTHVSGYANRFKEMLKFMAKAGDEVDILTVDTKTPAHELPTACSGFSIKHTQGFTFPLYNQISLTFDLPEMKGAQMLEKFKPDLIHVTSPGFMLFASIFYARVLCIPLVMSYHTHLPSYGKNYLSFVPGIENFCWELLRWAHARADLTLVTSPQMQEELTRNGIPRVDVWRKGIDTDRFDPKFRSTSMREKMTRGNADDFLMVYVGRLGAEKRLKDIKPMLERMPNARLCIVGKGPQEEELHDYFKGTNTVFTGQLDGDELSSAFASADVFVMPSDSETLGFVVLESMASGVPVVGAAAGGIPDIIDDGKTGFLVPPGDIAGFVSRLESLRNAKFRTQMAKAARKETERWGWEAATSYLRNVQYEKALINFHSRAFGGFGRPRSGTMWRLLGWRMRRVIHKVAKPKAVFSSIWRKLSFGRQENSNSGKPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDZ2</accession>
    <name>B7GDZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DHC1</name>
        <name evidence="18" type="ORF">PHATRDRAFT_31156</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185293.1">
        <property type="nucleotide sequence ID" value="XM_002185257.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B7GDZ2">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr31156"/>
    <dbReference type="GeneID" id="7199205"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31156"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_9_2_1"/>
    <dbReference type="InParanoid" id="B7GDZ2"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001013">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1680"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1968"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2328"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2673"/>
            <end position="2839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3012"/>
            <end position="3051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3159"/>
            <end position="3235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="3012"/>
            <end position="3038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="4020" mass="455351" checksum="BA11DA3B6F0AD3B3" modified="2009-02-10" version="1">MDLEALGLANYLQDDEFLNSLQATVNGWIVQIRKITTLPKSTPFLPDAAAEELTFWTQLQAELLHIQTELSSAPVELTVALLREAKRFVVVLALENNSGLEQALSYTQDVAHFIKPYPLPSLQAARSVEGVVEAVQSLFDHYGKLRQSRFYGLPRAIELLQATTLVLRDTLLAILQEQFSNLLFMDYKEYESKVRFSFLDVFVQFDDRFEEWKDFILEQGRRRKVTGLNKLIEGMSIHHLQLKDRLETIHQFRSSQERLRDVVHKVLREEEPAAMQQVESVPRQIFASLNVLDLTPSGTKALESALEEYDLQMDAMEERLAKLLRDKLTACQDAEDMFRVFARFNLLLTRRRVRASVKEFQIQLIATVALAVEKLQSKFTLKYESSAAARISRLRGIPPVAGKILWAKQMERQVQTLMERMGDVLGPDWGQQLEGRQLRKSGDELLSKLDARSFFHGWVTEWEKGLSSAAASKMNSYPIIVEPEGRDGVLTAKVNFDEKSELLFKEIRHLKWLGFGKEIPRTLSMVSDEAMSRYPYAIAVKTALRSYKSVRILVTPELERLVMPQLLEIRETISEAFDVKLSNSKVAKKRRVRWEGKEISEWVAQLTTSISKFEDRVEQLLRACDKVDIALNLLEEVDYNTDKFRAVLASIQKTIDDMSLSGYNDLDSWVRVISSEMGKVLSKRLEFALKGWNQTLQVTKESNNEDHVELIETAVVEDIPFPESITTKVSLEIVLRNQEISAVPALPMARAMFLNKLHEYFSVVCSLPRPKSGRYEVFDSVAVKNSQTSTGLEETFDNLVYLLPPKLVADAYGAIEAHIRQASAFVESWLAYQTLWDTQVSDVASSVGSDIEKWQALLLEASEARATLDTSATVAEFGPILVDYGKVQSQINLKYDSWQKELQSNFASILAQRISETREKIDGAKTRLEETTLTNASTESIVLGVTFIQEINQKSQLWRKDVDILHSCERLLKRQRYAFHSEWVETTVVKGLYDSLLQILERRTRTMEQQVPLLQTRVSAEDKKSTKELAGLIGTWNQDKPLRGNVTPPQAIEVLSKFEINLTKAHVHQENLGRAKDALGLEHTTESHEVVESLKELTDLKEVWDAMMEPYRSLEEIKDTLWSTAVMRKIRRALDDILASMRSLPNRIRQYDAYTQLHAVVKGYIEGHSLLSDLKSEALKERHWKTIFQRLGIRVPFIDLTVGILWENGILTRKKDVSEILTVAQGEMALEVFLSEVRDRWLKQELELVLFQNRTRLIRGWDDLFATLDDHIGGLALMKSSPYYRAVREFQEEGKLWEDRLTQLRAAFDAWVDVQRRWVYLEGILFGSSDIKAQLPAEWSRFKSVDSEFVSLMRRIVSKPFAMEVLNIDNLQRTLERLGNLMTVIQKALGEYLAKQRSDFSRFYFLGDDDLLEIMGNSGEPGKVLAHIGKMFAGIVGARRASGDVPENVKTRFDAMVSKDGEIVELHKPIDITAETTVKGWLKELEISMQTTLALLLQQAVGEDVYSTSAQLDEDTEVSFVGWSTKFPAQVMILAAQINWSMGVDSALGTTEPNAALADVLRVLEWKLEVMANTVLEELPADSRKKFEQLITELVRQRDVVRQLMKDSVSDPMDFRWLYHLRYNYDPKAEKVTEKLSVSLSNAKFYYGFEYLGIGERLVQTPLTDKCYLTLTQALHFRMGGSPFGPAGTGKTESVKALGAALGRFVLVFNCDETFDFSAMGRLLAGLSQVGAWGCFDEFNRLEERILSAVSQQILTIQRGLLERKSQIELLGRPVSLHNNVGIFITMNPGYEGRSNLPDNLKNLFRSFAMVVPDRKLIAQVMLYSQGIVTAEHLAGKIVDLFMLCDCRLSKQRHYDFGLRALKTLLVSAGALKRQAIEGRNLHGEDLALAEKNALIVGACNNVLPKLVAEDMVVFKEVLESTFPGSDVAKMEDTKAREEIVSVCKRSCFVPGEGFLQKILQLKQVIEMRHGVMVVGPVGVGKSTALKVLLEVLEKLDGTKGEMSIIDPKAISKERLYGSLDGTTLEWTDGVFTSLLRRIVDNQKGESDRRHWIVFDGDVDPNWVENLNSVLDDNKMLTLPSGERLSIPDNVRIILEVDSLAHATPATVSRCGMVWFSDDNVTNEMSLQHMLQRLATEDLMGDRVAGQQVPSAQIEFLNEITGQVISERTSSLVIDALEFALKQRHIMEPTSDRLLHTFRALLIQGIVLAIEYDENHPDFPITGEHMEKFAKRWLLHSLMWSFCGSASWDVRKSFSDMLLRTSGIIIPFGTDNTLYDYRVRVDDGEYELWSDNVPRMEIESHRAAASDVVITTTDTVRHSDVLGAWLTRRIPLILCGPPGSGKTMTLVNVLQSIQGVILANLNFSSRTTPEIILKTFSQYCSYVRRGKDIFLEPGESFGATSWLVVFADEVNLPEEDNYGTQRVIMFMRQLVEHGGFWRNDNVWVKTNRIQFVGACNPPTDAGRVEMSRRFMRHVPLLLVDFPAKDSLMQIYRTFNGGMMKLFPNLKGETEAMTEAMVELYTENQRKFTPAMQPQYFYSPRELSRWVRAIYESVVNSDQGLTREELVRVWTHEGLRLFADRLVDVEDKEWCSSKLDEVARKWFAGVDFEIALARPMFYTTWLSKDTRRVERGELKDFLSARLRVFYEEELDVPLVVFDEVLEHVLRIDRVLRQPMGHLLLVGDSGAGKTVLSKFVSWMNGLSIFQIKAHSRYGMEDFNEDLRGVMRRVGVDGERVCFIFDESNVLSSGFIEAINALLASGEIPGLFDGDDYTALMSAVRDTAARDGVILDSDEELWRHFTSIVQRNLHVVFTVNPSGGDWKNRSTTSPALFNRCVVDWFGTWGSKAMGEVGREFTTRLDMGDSETEGGAWGIGEGEELMKRVEDAFDDNSTGGLRQAVVAALVNMHQIAREMAEEIASSPSSITRTFLSPRDYLALIQNFVSCFNERREKVEDEQLHVNAGLSKLKQTQENVAELKQGLGTKTAELRKKETLANEKLQQMVADQNIAEKRKEEAERMSVEVEKQQKQINERKDRAQKDLDEAEPALRSAQASVRGIKKRDLDEIRNLSRPPNNVKLTLECVAIMLGETSVDWTDVRKLLAKADFIPSILNFDVDNLSAKQIKLVKEKYLDGNSELNEESVLRSSKACGPLYKWAESQIKYSTIYNNIQPLREEVAQLEEEADIIKTEKYKIEDEVKELEASIASYKADYASLIRDVEALKSEMEAVTMKIDRAESLMTSLSHESERWSKSSETFQTIMRSLVGDGLLMAATLTYQGFFDFKVRSMMMSRWKKSLECLDIEFREELGIVESLSTGAQRLTWQAQGLPGDQLSLENGVILDHGIRFPLVIDPSGNAIDFLMNKHKDEKIQTTSFLDKSFTKTLAGAVRFGTTLLVENVERIDPILNPILNKEIQRTGGRTLVRIGTEEVDYSPQFKIILSTKNPGVQLTPDLCSRVTLVNFTVTPDSLQSQSLRHLVKSLKPELEEQRATLLKLQSEQNVKLRELEDQMLAKISACEGSILDDDRVVEGMEILMKEGSQVEEQISHSAEVMKQVHQAVARFEPFAAVCRKMFVLLEALRELSFLYEFPAKAFMTILEHILEHESASREADEAARIGALKMALFRETAARIGRSLQVDDKLVFSILLARFYQNDETMGSAQSESSEDLIAVITGVFGEDFPWQGRALNDLNEVTESEINSTVPLLLCSAPGHDVSGRVEAMARDLGKELFSVAMGSTEGYATAESMVAMASKRGTWVMLKNVHLCIEWLRDSFVKRLQTLGSQTHKDFRIFITSEMNDRLPAALLQISDLMVAEAPTGVKASLTRFFSSLSKDRLGSSSMIHNRMYLLLGWTHAVIQERLRYVPNGWTERYEFTEADAWHGLDVIDSLVSTSGSLDESNNRTPSDPEHLPWDAIRSTLCKGVFGGRVTSEVDQRVLDELVHAVFVPASFNVDFRLVEGSTTSPTLPDGSRREDILSWIASLPTHTPPAWIGLDRSAEEEREQRVVQSVQDKVSKMQVQCESDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDZ4</accession>
    <name>B7GDZ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_50397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185294.1">
        <property type="nucleotide sequence ID" value="XM_002185258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDZ4"/>
    <dbReference type="PaxDb" id="2850-Phatr50397"/>
    <dbReference type="GeneID" id="7199206"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50397"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332768_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDZ4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47759">
        <property type="entry name" value="OS04G0509100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47759:SF2">
        <property type="entry name" value="TRIGLYCERIDE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="659"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="891" mass="95876" checksum="EB4E36E02452A948" modified="2009-02-10" version="1">MSLGRRVGVVSRCPCRCSGFGPGRDGNRRLPLLLNLPLPLLLVVALWLTSIHAFTLSSSTNRHWTAAGRPSLVTLPGSSSLASSSSDATEEQQSGVKAPPDTVPDVTDTDTNDGDTVVDARPDRGTLSTLQCGNLELGTALFAGGLAFDAYVEPPSNSSRWEKGSQGLRVAFCSVAYTRQLYKGVLEVRVRTCTNLPQDESNTAERMLSGNGADACVLVAALEGAWKQDVQRLEKEQYHEGVLDLSGAAHVGRSTTAWANVNQKQSQAAVRKTGRALPYHIPGGWGKGGQAVWPETEEPFYLYVQDPATARLVVTILDDDKLAGAGTPIGSTYKRLAELIPQAALPPEKLLTSLKQELIDQVQNGNLDLLDDASKIKLGAKTWDGVLKMTSKPRKKDKNGQVLAAAAAGAYVAGPVGAAAGALLGSFYEGTPQGSVQLQVRYLPIPPNVAISRQTYVVKGGMPGVDWGTLLERYKDKTLRNPDSTLKPMEQKILGTSDLEHCFFINHDKTGATCSVYRSLDQKLIVVSFRGTCAPVDLITDANLVQEAWVEGDDVKDPLIPKVHQGFRSSLNSISRRLKELLLATVQPGDNLSDYDMLVTGHSLGGALATLFVADLAQYGIDAGRGLPQLEPSEPWWKGVADTFMGQQAREKASQATDPPRPKMLRLYNFGSPRVGNDAFSDLFAALQSEQYIDQAYRIVNGQDVVARMPRTLNALVTSVGYEHCGTTVLIAQPSNATDTNPNLAPLVWVEGESDDNKCPVRDGVALTSPLAEGSLLSDLMETTRDLLADETTDTSASGGISAGWSASWNKWTATATKVSQRFQSLTATDVASVLGLQREFTTRELELVQALLQGKALAHHLEDEYYAGMGRATGFLARVGEDVVEFPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEA4</accession>
    <name>B7GEA4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_50498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185402.1">
        <property type="nucleotide sequence ID" value="XM_002185366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEA4"/>
    <dbReference type="STRING" id="556484.B7GEA4"/>
    <dbReference type="PaxDb" id="2850-Phatr50498"/>
    <dbReference type="GeneID" id="7199283"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50498"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403609_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEA4"/>
    <dbReference type="OMA" id="KMFANDI"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="227"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="539"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="682" mass="74067" checksum="BC5BB9219DF11851" modified="2009-02-10" version="1">MPQFLAVVSGFLLGSALTYAWLSRQDRSSSKTLPEDEPSSTSRSIATPSRQAGPTAHLRTDGLLTDLVRELWSYINVAGCDTIRSTVEPMFVTLPGPLKTLRFTKIDLGSVPIRMDNLVVHEVHNDSVTVAMDVAWDGNCDMQLKADYIGSFGVKAIKLKGRLSLLLKPCVNALPPFSAIQYAFVTPPQVEIDFTGLAQVADFAVLDKRIRAIIQDSFACVTLPSRMMYKTDPACDYLRTYQPPLGVARITVVRGRGFHVEKRSLRAHDVPDVFCQVSINASQPFTTRTVKDSLEPVWEESCDFIVMDLDQHVILNAWDEDNGALDANDDLGTAKVSVGDLLLAGKTKEVELLEGNLKRTGAFVTLHCELLPWTSGESFEGLPKAPTESTNTANSLAGLMTVVVVKASNLPLAKKEDAASFVKVKYGAAFEFLTSVVLPCPGLDALNPVFDEVTFIPLPQALVDDKNDVVLELWNGQAILGSVNITHQSLLNMDDHVRTENLLVGDKGAKLFFRVSLQGVAEAPIGIPTVSAIEPMGKDDSEDPGTAAALVGGTLGKVSVTAVRGWGFVVEKRRFKKNDVPDVYCNIQFGSSPTVWRTKTVRNSTTPTWNESSTYPLSDHSQILHLNVFDEDGGARDTDDALGSARVAVGKILLAGGSMDVELLRTGKPTGCYIQVRCALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEL4</accession>
    <name>B7GEL4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_41582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185504.1">
        <property type="nucleotide sequence ID" value="XM_002185468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEL4"/>
    <dbReference type="PaxDb" id="2850-Phatr41582"/>
    <dbReference type="GeneID" id="7199369"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41582"/>
    <dbReference type="InParanoid" id="B7GEL4"/>
    <dbReference type="OrthoDB" id="48601at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="874" mass="96152" checksum="EBB1E0A468C3FFD1" modified="2009-02-10" version="1">MADADAPNAPEAGLAPAVAANAPGIVGDAQAAAYAAFAAAEAQMANALAVLAGEAPPDAQPFPPPPGVADIPVGLPPVVVDAPLIDPYDSLLMRAGMNYGTRKAFSKEGYGLMSDLVTLNQKRLESLIDMMNKKHRGKSFQGAIPLGLNLVAEDLEIDIGHKTKTTLKVILHWADLQKSLGLDVNAEDYTNVVGQLARERMDEEEKILEAAKKLTPSKPTTLKDMTKWRSFFENWNSYMSQCRSAAAIPLLYVYRTNEQPETALVGTYVNMDAYLVAQTVLSGSNFEIDNQRVFDEFKEAITTTGPGWSFIKTYNRSKDGRAAILKLKEQAEGTLNESVCRDDAIKILSTTTYNGPSRNWNIDMLLQKFQYVISELVEIDGVALPDGQLVTYLVQALKDPSLSYVNDVQTSGSGASGGSMKGGTGKGASKPTPFKGAVTARSYTPGEWKSLSKDQQEKVRSLRNKKKQGGKPEESERNVDSVARDEPVDTKEVHTSREMEPTSDAAGLQFGRDTCVAGANTVLIGESQKSVTVRPFSSEYSALKNIPIGTVATAYTVPEDGRVVLLIINQALFFGDRLKNTLLTPNQMRDFGIEVDNAPRQYVANSKHSLYVPDSQLRIPLQLRGIFSFLESRKPTQQELDECEHIILTSDVPWEPCSADFARREEEAAKRDRSVSLVDTTGLSTGHAILSAHPYGIRTVAASQRILETFCSLTEVELCETNLADRLIACVNVASDDYCGDGLDGRADLDVYPDSEDFTRVVSVYDGSKEQGGGKHWKEIEQRHHIHRHVTEPHSQWQNRAEGEIREIKKAVRHQLQVSRAPQRLWCFCCEWVSAIRRLTAHDIPALNGRVATELLEGDTPDISEYAQFDCHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3K9</accession>
    <name>B7S3K9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176155.1">
        <property type="nucleotide sequence ID" value="XM_002176119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3K9"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1556"/>
    <dbReference type="GeneID" id="7204849"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1556"/>
    <dbReference type="eggNOG" id="ENOG502SQU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740742_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3K9"/>
    <dbReference type="OrthoDB" id="45955at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40957" checksum="54D30753B75EC2D7" modified="2009-02-10" version="1">MSNATRSHRIANSFAGGCWQTGRVCCCRYGLYPLLVASFLTTGALLSLYNAAGCDFVDIQVGFTPSNSAWNQSQASLGIWYYQTDAPSNYSTYREKLQEGCQRYTQAFEESFVDGDRTWIVARVMATISACCSIVATLTSWLFCFSTSPLSFWSCVLLPTSMVAFIAEVSKFILFDISLCRSSLWFPSGVDSLPQAAESCSLGKTANSAVASGSILLVGFAMVCLKIPRKRVLDPQYAGQHVTDAGLDWDRNGSPQKSINTDADKKYKDFSNELLDTSQNLSETSFDAEESIPSSGGCSNQDSSIHKCGQSQNDCPSDEKSATDDFVIFGTQRVSESRVAKLSKMTATANMQSEDLINKFVQEFDEAFQESDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N9</accession>
    <name>B7S3N9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_bd223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999262">
        <property type="protein sequence ID" value="EEC42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176183.1">
        <property type="nucleotide sequence ID" value="XM_002176147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N9"/>
    <dbReference type="STRING" id="556484.B7S3N9"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft223"/>
    <dbReference type="GeneID" id="7204970"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd223"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1135390_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N9"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20596" checksum="B6AB3C792890E4B2" modified="2009-02-10" version="1" fragment="single">RLLGSYQSLCARRPLLTKAISAAVIGGVGDLLAQILERVSLFTFTIQWYRLAVFVMTEFLFDGPFLHFWYEFIYKIGQWFETKFGLSPRSRLKTLFQFSVDQTLGVAIYYPAYFYAYEIVEIPSLVRATAKCRDQLGPIIRSQYVLWPAVSWMIFRHVPERLKTLANNVVAVVWNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7S412</accession>
    <name>B7S412_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_bd1315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176318.1">
        <property type="nucleotide sequence ID" value="XM_002176282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S412"/>
    <dbReference type="STRING" id="556484.B7S412"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1315"/>
    <dbReference type="GeneID" id="7204888"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1315"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_4_0_1"/>
    <dbReference type="InParanoid" id="B7S412"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051169">
        <property type="entry name" value="NADH-Q_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913:SF9">
        <property type="entry name" value="SLR1591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="496" mass="54544" checksum="0E5F8B80BCA3B68A" modified="2009-02-10" version="1">MLRPTLSSSSSSSLSNAPSTDTTHSNADSQHLVLVGGGHGHVQVIKALRNRPSNLRVTLLDATDAASYSGMVPGCIADAYTPEQTLLRLRPLAEWAGIDFRQEKVVDVDFERKLLYTDQPDSDALSFDVLSLDIGSTSRDWQDVPGAAEFTIPTRPIDQLVRRLDAALDGVRARVATAGIELSMAITTRWKHFTPNVDCTVLDAGSQLVPHESPTARRKLQSILRDKHITVRHDCHVDHVTADAVVLTSGDRIPFTCCVWATGAGAHTLARTTLAQRGLEVDKYGWIRVHPTLQSTSHDFVFAAGDCNTIVGLPEDQPSPPKAGVYAVRSGPVLIENLMRYSYPADRASALVPYTPQDDFLKLLVCGDHQAMGFRFGLALYGSWVFRMKDQIDRNFMKLFDVAHLPTRDDTTGSDAAASPTRQYDDSDDDDDNESKKEKVRLSAMDAAALLRRTDDDVDFQVAQSVLRRMAADDSYRRDVLAHAAEHETIESPVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4K7</accession>
    <name>B7S4K7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999304">
        <property type="protein sequence ID" value="EEC42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176497.1">
        <property type="nucleotide sequence ID" value="XM_002176461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4K7"/>
    <dbReference type="STRING" id="556484.B7S4K7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1540"/>
    <dbReference type="GeneID" id="7205102"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1540"/>
    <dbReference type="eggNOG" id="KOG2353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131523_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4K7"/>
    <dbReference type="OrthoDB" id="202775at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002863393" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="246" mass="27241" checksum="CF30C7926223A2AF" modified="2009-02-10" version="1" fragment="single">MKILVFTSVFIHLSSRLSVTKATEADFDALIASMEADTSELARQVEFLYQTRCSEASMEACARANYNECTSLYPNQTCPGGQDLNVAQCGDGVSCASLWDYSVSNTRLHTDLIGASGGNPSDPNVIETVCFTQQLDEFFIRKRAEQKPYWDRLGLRTPQMYFGSQNGAFRIYPARQSETCGAFDPRVRPWYIAASSGPKNVVLVLDTSNSMTDKSRLALLKQAAKQVIKTLTVGDRVAIVDFSWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3H7</accession>
    <name>B5Y3H7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_36721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185658.1">
        <property type="nucleotide sequence ID" value="XM_002185622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3H7"/>
    <dbReference type="STRING" id="556484.B5Y3H7"/>
    <dbReference type="PaxDb" id="2850-Phatr36721"/>
    <dbReference type="GeneID" id="7204610"/>
    <dbReference type="KEGG" id="pti:PHATR_36721"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y3H7"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="323" mass="37257" checksum="08FBA8BA26F96A7B" modified="2008-11-25" version="1">MPAPKKPEDPQEAAKNQAIDKELERAKQQEDLKVKLLLLGAGESGKSTIFKQMRILHGAPRTEDDLRMYGVVVRSNIVTAMRKLSLWRPIKVLWQSKTMKEVWSRRAAMNVIDGHKEYLQDLPRIASPDFQPTQQDILLARVKTNQVVMERYRIDGIEFEMYDVGGQRSERRKWISCFENVDAVIFVAALSEYDQALAESKRTNRMSEALELFRSVCNNRAFANTSIMLFLNKKDVFAEKIHYSDIVSQTPFSDYPYPPREFNSGVLYFIEKFKECLIDDDFNDSFIHVTCATDTNNMEFVLDSTRTIIMTDNLRRSGFLGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3X8</accession>
    <name>B5Y3X8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinetochore protein Nuf2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATR_46838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185912.1">
        <property type="nucleotide sequence ID" value="XM_002185876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3X8"/>
    <dbReference type="STRING" id="556484.B5Y3X8"/>
    <dbReference type="PaxDb" id="2850-Phatr46838"/>
    <dbReference type="GeneID" id="7204691"/>
    <dbReference type="KEGG" id="pti:PHATR_46838"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_2_1_1"/>
    <dbReference type="InParanoid" id="B5Y3X8"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="152"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACI65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="405" mass="46698" checksum="BD0794A88B2B328F" modified="2008-11-25" version="1">MDNTEIQQSVGYSYPQLKPTEIVQCMEELGISLTKDELLEPQKHKDKIRNIFVQLMTTCTGKSDEDFQATEAMKAKANTMEYGDQLHADFTDLKFFLTLQTLMIDCGVPNFSWRDLYNPTHKRLKVQLAAIINFLRFLQERLKLYQELNEPRTELLEAFDEVQVEHDELKAQLEQTELDSKDKLDAMDEVVQECQGLELEIARNNKLQAAAREEAAALKMRANDLKDELATAVWAFQEAEAEEERLRAQVVSSPDRRRAELEHRSALLTKAKDDCNKLENDVQSAKLKTVKVKQASKDLESTLVILDDLREEATKLADLILQKESTLKEMDSFMKKKNDFFEESEEAERYLHRTEERISHQVKAHKMQIAATQESLDLAKSQLLAVEKDRREGMLRVQAGEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4R8</accession>
    <name>B5Y4R8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_43917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186341.1">
        <property type="nucleotide sequence ID" value="XM_002186305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4R8"/>
    <dbReference type="STRING" id="556484.B5Y4R8"/>
    <dbReference type="PaxDb" id="2850-Phatr43917"/>
    <dbReference type="GeneID" id="7204358"/>
    <dbReference type="KEGG" id="pti:PHATR_43917"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388595_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4R8"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="784" mass="87023" checksum="082B38D57348807C" modified="2008-11-25" version="1">MPEPAGIVELRRDRDYGGGDGEGSAVPTITTRETGFLQTRASVSTIYGGFAVVPNRKRSQHDPTQPRTPPRLPDEASLFPVAPAGSLPLVGYTHKHVRNSFRCVTVRAGMKDTQQLQLLVCSANLGNEQPDPDSLAAWIPTDGACQAVLRQDAPYPVQSYHYSSSTNHNNHNNNNNTSTRSLEADNDVPSDASRYTDTDQFDMIVIGMQEATFDPPAGATRVPVVQPILEKGVKKALDTVNNLTATRDHTKKTASIGVPDWSGGTAALHKMLELSLPSYQHVVSYQRGQMRLEVFTHAQQIDVRVLRTTAQNTGRGGLANKGGIVTELLVNEHTRLAFMTTHLEAHEGASKCAIRSSSLGDILGGTKTKLHDVSQTAHYTFVLGDLNFRTELPGSHFLSEEDHKARVWNWVATRNWQALNDADELQRELRNKNCLVGFQTLRCNFPPTFKVERQPGYQYIDKRRPSYTDRILWKTGHQMEQGVVPLVYEPIDVFASSDHKPIRAAFGVDLNDSFRMRPKLHRNHSHINLSTLLHRRNSQPNLRQPVVAHRDKLQLFVSGMACQLFPNRDLPPNPYLCLVSSPPDALQTLGKVGGQATTAQGWPRSSLQMSTNTPKWDGEEIHCQIQTHGADGSSLDLTGALLHLTIMNYNPSNQDSVVGTFTFNLVNLLRSCRRTSPETNSGSERDLQGKRGPRNLFRRSQAQTAVWNDPITSVDLDESICLNGMETGRIQCTIDAWWMDTAKALATRPGEDRRSAVHRYTIANQQRRGSNDMQPSSGASMNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4T9</accession>
    <name>B5Y4T9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_25666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186352.1">
        <property type="nucleotide sequence ID" value="XM_002186316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4T9"/>
    <dbReference type="FunCoup" id="B5Y4T9">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y4T9"/>
    <dbReference type="PaxDb" id="2850-Phatr25666"/>
    <dbReference type="GeneID" id="7204368"/>
    <dbReference type="KEGG" id="pti:PHATR_25666"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4T9"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="759"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="885" mass="98727" checksum="7F21D39510986A45" modified="2008-11-25" version="1">MKFNYKLKRLCGAYYGHPLTNETTGGTRWSGSNVVYDSSGDLLISSVSNRIQVLDLRTHTVRTLPVESRSNVRCLALSPDDAILIVVDVKNYALIVNFRRGIVLHRFQFKRKVRQVLFSPDGNYIAVTHGKQIQVWCAPSQLQKEFAPLVLHRTYTGQADDVMCLSWSSDCSVIAAGSRDCSVRIWSLHTTRNFEPVTLSGHKRAIVGVYLIGNHSGRVETCYSVSEDGTLVSWECKLKEGEWDVDHQNRETPPEDSTDDASFWSVKSRHYFHQDGADVSSVTYCERGQLLAVGFSSGLFGLYEMPSVSNIHTLSVGNNQLVKTCVLNKTGDWLALACPHSQQLFVWEWRSETYVLKQRGHAYGMRCMAYSPDGVIVCTGGDDGKLKLWNATSGFCYVTMEKSHTAPITAVAFANASVVLSSSLDGTVRAHDLYRYRTFKTFTTPTPVQFLSLAVDPSGEIVTAGSTDPFHIYAWNLQTGKLLDILTGHRGPVSDLSFQGNGGILVSGSWDGTVKLWDLYKGNVPTESLQHTADVVCVTFRPDSREVCTGTMGGILSFWDVDSAKLKFEIDGRRDIAGGRKINDRMTADNNASSRYFTSVCYSADGSCILAGGNSKYVCIYEVSQQMLLKKFQVTFNRSLDGVLDELNSKNLGPGGPIDDHADSGDDTMYNALQLPGARRGDDGSRSSRVEVLTLQVAFSSTGREWATISGEGLHVYSLDEDMIFDPISLTETITPAAVESKLSTGDYIMALRMALHLNEFALVKNVLESTPFDSIAHVVRSIGPEHLERVLQYVAKVMADSPHIEFYLHWCLELLRTHGIHMDRNRGNFMRAFRATHKCVQTKYDELRAICQENKYNLDFLQDHARLLLTHEESEKMKVEDYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4V8</accession>
    <name>B5Y4V8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_43951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186075.1">
        <property type="nucleotide sequence ID" value="XM_002186039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4V8"/>
    <dbReference type="PaxDb" id="2850-Phatr43951"/>
    <dbReference type="GeneID" id="7204177"/>
    <dbReference type="KEGG" id="pti:PHATR_43951"/>
    <dbReference type="eggNOG" id="ENOG502S3QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805269_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4V8"/>
    <dbReference type="OrthoDB" id="46297at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="274" mass="30927" checksum="049E0594FA69AB91" modified="2008-11-25" version="1" fragment="single">MSTLRRELSFSSYKYQDDKPQHIDYSVRQISSLIVTRSQFWNLYPLVQAGLIPSSLPPTLEIPLIFLPTAGCLAMSIVLRDSFRFYAVIDTGSPFLTAPEGATEFSHSLARMYPATEEQYGESKGEMLWRHCRTRIRGLETPLVFGVPQNNVLEETGGIFAGMILQDDSRPTFLKQLGYSSFVLDYATRHLQLSRQSLLLNDLNAMIMYDLAPFGPNLHHYALECQAVTLYTGKEKIDISNRLSRPVVVVIDSGLTGCVFSDSWKEDLPCKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4X0</accession>
    <name>B5Y4X0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_43961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186082.1">
        <property type="nucleotide sequence ID" value="XM_002186046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4X0"/>
    <dbReference type="PaxDb" id="2850-Phatr43961"/>
    <dbReference type="GeneID" id="7204382"/>
    <dbReference type="KEGG" id="pti:PHATR_43961"/>
    <dbReference type="eggNOG" id="KOG2521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4X0"/>
    <dbReference type="OrthoDB" id="67864at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="181" mass="19953" checksum="0DDEB354EBC2F819" modified="2008-11-25" version="1">MNASNHSFCVDDYPDKKPKAIVLLLGWWGAKSRHLAKYGQLYQERDCLTVQAICDTYAILVRNTRSIDQCAIEAAAHVAQVLRDIDDDTIPVIFHAFSNGGAYVVERMEAMIRHARTNSLPSDQDSDMVLVGKHLQGQIYDSAPVWPTTESAVEAAAVHFIPLPDFIPCDGLAASILEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y506</accession>
    <name>B5Y506_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_10454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84099"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74410"/>
            <dbReference type="ChEBI" id="CHEBI:233601"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186099.1">
        <property type="nucleotide sequence ID" value="XM_002186063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y506"/>
    <dbReference type="STRING" id="556484.B5Y506"/>
    <dbReference type="PaxDb" id="2850-Phatr10454"/>
    <dbReference type="GeneID" id="7204201"/>
    <dbReference type="KEGG" id="pti:PHATR_10454"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y506"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF27">
        <property type="entry name" value="LYSOSOMAL THIOESTERASE PPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACI65569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="33214" checksum="3A6D753D46E6B23C" modified="2008-11-25" version="1" fragment="single">SENKQLPVVFAHGMGDSCFNSGMQHVAQLASEWLSEDFGPDRSNVYSVCVPTGATQAEDTKNGYFLSMDASVEVFAEGVRADPRLSDGFHAIGFSQGNNVIRGYIAKHNTPTVDTFISINGVNAGIGAVPYCRPSETAMGAVRLGGMCDLLMEQASRSAYTEFAQEHSFQANYWRDPRPTAFPLYQKYGQLAAWNNEAGLVNETLKTNWGKTSAFVWVLATEDGLVWPKEGEQWGQPDSKDPFHVILSINETTWYKEDLFGLRTANELGKNYFESFEGDHLQFESADLERWVKTYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y570</accession>
    <name>B5Y570_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_33402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186133.1">
        <property type="nucleotide sequence ID" value="XM_002186097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y570"/>
    <dbReference type="PaxDb" id="2850-Phatr33402"/>
    <dbReference type="GeneID" id="7204004"/>
    <dbReference type="KEGG" id="pti:PHATR_33402"/>
    <dbReference type="HOGENOM" id="CLU_231281_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y570"/>
    <dbReference type="OrthoDB" id="40779at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="207" mass="21900" checksum="EA1F7C45106596A2" modified="2008-11-25" version="1">MSRVLPVGLVQASLSSLVDLSTSKGANKELAHVKAYIYAQAILPLIADSNRDAARTISDNVDFAGEPFKIGLRDVAVAYSIGLSGTGLDCSQIGSSDAIDGCTGSVSSESKLGIILGVLLGSIAAIGVAILVRVRRRRGVQDKPSFVAPKGILNHSSEQLVGRCRESAPERVGSETQELSEDYNDADSIDREEYLDQAPENCNHDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5S0</accession>
    <name>B5Y5S0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_44224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186237.1">
        <property type="nucleotide sequence ID" value="XM_002186201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5S0"/>
    <dbReference type="STRING" id="556484.B5Y5S0"/>
    <dbReference type="PaxDb" id="2850-Phatr44224"/>
    <dbReference type="GeneID" id="7204059"/>
    <dbReference type="KEGG" id="pti:PHATR_44224"/>
    <dbReference type="eggNOG" id="ENOG502SB1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595293_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5S0"/>
    <dbReference type="OrthoDB" id="42181at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5T3</accession>
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        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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            <taxon>Bacillariophyta</taxon>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CCAP 1055/1</strain>
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                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
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    <accession>B7FP83</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
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                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002176626.1"/>
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    <dbReference type="GeneID" id="7196106"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42699"/>
    <dbReference type="eggNOG" id="ENOG502SR5W">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52939" checksum="0CC3C6DDA8DAE3C4" modified="2009-02-10" version="1">MRSFLVIGILIAMPALGICAFGTGTICYRSPKTPRRQPTPFSRGLLSRHLFGNRQNKFLKSEFFPLDEIPQEERAFLEEVKLRPKFDRESLMEIVIPLMAPFIAFFSYDFVASTFDWTIDTLSDLTSDKNWVAVDGGRYQASIMTPVTNGVVLPAVAVLFATLTSTTISTLRMRQVEVLRAINMEAGELRVLESIVAVFPDGDLKDRCRNYLIQYTSRIIAESQPHSGFVGDDFSSINPRRGMDSELNGFLQQLNLFTPDISSHLAEESYAALARLREQRYNRISALEVTYPGLHYAILAALAIAECTGFLMEANQELLVFLNAVQLKILWSMLVGTFVACFTVFYDLRYPFSGSYQISASVDQLYTVRMALQAPVTSFLELESETKGSDSAVTTATDSWTPVANGSNSKCVAIMKVNGASRGTLNGAFQENTPEKEPLDEGIPSKPFSRTQSLRQQQQHTTSYLRNGSSHTPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPD0</accession>
    <name>B7FPD0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176689.1">
        <property type="nucleotide sequence ID" value="XM_002176653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPD0"/>
    <dbReference type="PaxDb" id="2850-Phatr42738"/>
    <dbReference type="GeneID" id="7196369"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42738"/>
    <dbReference type="HOGENOM" id="CLU_579350_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPD0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="472" mass="51276" checksum="68B8A1F5FBD1258A" modified="2009-02-10" version="1">MNSNTDLDVALSFTSEPSALTVSEISDFSIYSQAENDTGTTSVPERAAQPLDTNSEFHVNDYLTSKIPGDGDSQIKTTHISDELKSQVKKETQDAADIPIPTMLRRADTTPGAFHQPGIGSDRTAYPSTRDEEAPQDLSFAGEHLVSATLVADQHTGEFVVAKPVSWQKRPSILLLVAVILLLTLTAGLSTGLTKRADEDDEIDIAQESFSDVPSEFYNISSFDRQASFVVAWGENSTCAKSLASPAVEIYCNGAAVLVIDDTQQASCSRQSSTAMTCVLQKAAVEATVIFSCGGNAEAHDLAAISLVSATVFNDCSSRLDHDDIGFAIFGGEAIQYSSHGEFCRDYQNSNIWIIENSDRCGVNKKETFLDSHIQTEEDGTIRSVNQVYCYATKYCEDRRSCVDNLCQATGECTNLAVDTIQQDISTEITDPRCSFAPGAGPTLDVMRSVVGNRWGNRDDFLHRSSRDSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPX9</accession>
    <name>B7FPX9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_9115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177292.1">
        <property type="nucleotide sequence ID" value="XM_002177256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPX9"/>
    <dbReference type="PaxDb" id="2850-Phatr9115"/>
    <dbReference type="GeneID" id="7196469"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9115"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384261_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPX9"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="240" mass="26405" checksum="62830CBA87AFBAC2" modified="2009-02-10" version="1">MWKAQGVYSASTAAASWYSRATDYYEDNCPPTVDGVLGGFAAISDLDLEGSRAFLNDVVVQRGYSSVIWSAGAACECGAGIGRVSKGLLLPLGVQRCDLVESSPRLLAAAPDYIGDDGGVERCRFYCQGLQEWMPRKSSYSIVWIQWVFCYLTDEDAIAFLRRCGESLLDSGGVICLKENTCDDQDFIVDVEDASLSRSARYLHWLAREAGLRVVHAQIQDNFPDQIFPVYQLALEVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPY1</accession>
    <name>B7FPY1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177293.1">
        <property type="nucleotide sequence ID" value="XM_002177257.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FPY1"/>
    <dbReference type="PaxDb" id="2850-Phatr42892"/>
    <dbReference type="GeneID" id="7196470"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42892"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="InParanoid" id="B7FPY1"/>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2836"/>
            <end position="3400"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3700"/>
            <end position="4034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2402"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3407"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3409"/>
            <end position="3424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4067" mass="456322" checksum="6E1B5DFE3BC0B494" modified="2009-02-10" version="1">MASEPDYSANTNASSSSSAPAGSMNWEPVQQRLLDPDLNVAWQAAKELRDNVEVAHSTEYPLLLSALSPAFSSILTQRTKPNRDTNSVEHKLRHAILDAVSKFPSNEVLRPHAPHLVAIALEVLNRDYEANALLSLRIIFDLYKTYRSLPQDYVQPFLDFVVSTYRALPRAVQHNFAWEHLNFKATETSKTATTTIISTPITSTATPTTTATTATIAAAEPVEEKDQDGDLTMQDIEVPATGPEVKSSTPASSVPSGSASVDSLGSAIPGHPNSPEARLPVRSNLSFRVLTECPLIVMLMLQLYPKFLKTNIAALIVVMMEALAIRSPSLSSITPPEIASTDSPVKRSYHTRVRELAAAQAKTLSFLTFLLRSFQAELKPYEDRLASHVVALIKSCPRESTSTRKELLVATRHLLSSDFRKGFFRHADVLMDERLLLGSHYRSADQASLRPLGYQTVSELVLNVRSSLTMLQMSKVVSLFSRVLHDEGSTCPMPTQYLAVRTLLNLGDVIYHNTDLNPQLGRDLLVRILNTLTEKLTALNEYYPEVQRAELKRGEIVSPTVQTTSCHDSVRDLQSMIRAIIVGNKNIVFFLSNYRNQRDKEKVRETLVPPPGSNEEVSSAYHKLTHTEVAILDRYIIASLPALKLLKMTSTGQSRVGGEKTLADHHRDTLTYFAATFAALDGYNFRRTIGRRLNLLVDAIVEDPLVMIVPRHLLAVNAGTSYEFCSMLTCYLVERLDDLALPHRNNIVFLKPSCGQAENGKDVVLEQLREISQNPRDSEKHQRQRSSTYLQLFERALKSLAPYPENESTIRRYLRFVVSECLRSSLETSELWPDNYCILLRYIFRSISAGKFEESYKELLPLIPTVLNGLYRVICTADDTMLRRTAMELCLTIPARLSSLLPHMNLLVRVIIPALDSNSGDLVNLGLRTLEFWVDNLNPLFLYPEMSKDIPLLSAIMRSLSRHLRPAPYPYGLLTLRLLGKLGGKNRHFLREPLHLTNTSNFNTEAVEVDCSWIVGDENSVKPLKTTTTIALPLDRCIEMLKTIATSQEFVELKICVEDEPTALKQTVIPWGEYEVLWSTHLENVDFEAYSKGVSNETRRSQAHACLSIIKTALGVLETSRKQHEQKDAAKARDLLSSFESYDENVTPGRLVALALMFARMIDSTKQESQNLLIGAVGKLPPADLSDALADFLSEPILGTNTIAIEISTYFLKSERSLENSDVVTFVEHLVRRLCGTCCSATWSRQRGAQLILLFLVTELGHEWALEHELTLINAAIISVKSVPRELSTASIKAVEFFVRICEGVYGKLNRAQILQQGLMWDILSDDDNRILQYTRDSVVTLGDDDAIDQIVKSDNLSQTTEAPSDSTEIPSTRKKGSEEKTRLTRPSKEVFRVMIRELISAQHAVRFVARFITSLYIVPHWREGNDQRDEAEHPTFIRRAVLSKSMKLLPLPYQVGAIEGLASVVKLFPGVLPLDDQHFLGFLSELLKMTSVPEGDMQDPSWADSVVDKNGFAGVSSERLNIGNPTHASALFCRRECILNVDGMTLVVPAELPMGVQLRVSAIKLFHAVIVSYADAFFNADKSTPIGKIRSHAVSLLFRSLVSQPDRAAQAAYVALRDARIPKTAEVEQSRGHSCLSKDLIQTCIRPVLLNLRDFKRLSIPLLRGLSRLLSLLSSWFNKTLGEKLLDHLQKWTDPGNIMSSNIWSEGQEPHVAAAIVDIFALLPHASNFVEPLVKTCMKLDATLPAFKARYVESPYRGPLVRYLNKHPGFTVSFFFQRLRTPIYSELFHWLINVDGSTDLRSYLSNKQCSVMILNVCFETPLAIMRSERTSPASGSRISLALHGIGQHSTASQNPGGTSARMMSTEALELQFQGFRIVESLMANDISYVKDHNDIVRAFRWLWRSKGRALRLQHEESLSPRFHDESKMLASFLLSYAKSFPNEDLDILFELVRVYIQPSGVDLTFISRYLEEMVSNVLTAEQKKRVLERFFDLVSREKNEEIKVLSIHFLLYPMILATHKEESRDSSLRLVDSTIVERFTKEVLFSQGAPFACGERLKVELLRLLDLIVEQTKSAIEPFRKDVVRFCWALIKNEDASCKGWAYVLICRLVESFETPKKIVNQIYSALLRSHQQDGKDLIRRAIDLLIPVLPKRLDEDDMRRAIDQASHLLFEDNSSTPQLAHICTMIVRSPDVFRPFRIRFIGQMINCLSRLGLPPNSSAENRPLTIDMVDLLWEWNSNVAESLPLISHEQMDVVGNFLVRLKIVSSEEKPDGRTAKFDAGLPSFDERLSCLLVKVLKQKGVDIRKQPFEKVMEKNLGDSGPVLASLDLFVLMLESGLHEFFTANEVLVEKLVLSAFSHAKTYEPLRKKLLFFTHASCSSTKLTSIVILCVEQIIIESTDTQKKRSPGKQPEASRQVHGRSSKDKEKDDATKIALAEFYRFGLELASELCRQSDSGLRRLTNVLLNLLAVLTKTHVLEAAAKQRQGGSSGPPTNTPGVLHHTPTKGILEETCDQFYGDQSRILGGGKTKGERENSERDDAVRSLVVTLGIFERSDVAFTFTQSRKNLFQILSSILDSSDNVQLLMVATRVIGKWLLSDDSGGPLTSKERNSFLWKIASFDSNGLSDDLTSQPLADLVAYFVQRVCFGVEGKLKDGEGLVIGRCMVACLLHAQEDVRIRLITSYVCGFPSELSSRGAAAMNRSVVDVFWRLLNSDIEGLASRYWTVFYVDCLISCLSTKDYHCLNGLRVLAHGDTTTCQKLFEWLLPAIWDIIPSDAIRLRISTGMEFLLSRPFHAQFLKAATFTPGAERRCSNAVRSFLSGVAALAPAPVLEPYLLVSLAENYNCWFESISLLEKHFSLLGSTPKGLLSLDAMGHCYRRLGEDALCLTLAKEACTLPETAIAIGLNVYGMVSEAAKQYEGLVDSAGGREFKHVPTDFEMDLWEEHWIGLQRELCQLDIVSEFANSAGSLRLRLECAWKVQDWNTVRSLCTSTSLLAAVESGDPLVKISETLLAVADGKLSEVENLHAQTAQLCLHKWQLLPLLSSGSTSHTSLLHFFHRLVEIRESGQIMVETSTHSSEKTLPDLKNLLNAWRHRLPNDFDPIASWDEVFSWRAHMFSAITSNFHWSEPNTLATLHDRPWTAIRMAKTARKHGMRDVSLLTLNKTVDERAMNVSDAFLKLREQILAYYNPGSDAERHGGLNLINTTNLSFFDQPQKSEIFRLKASFLASLGFRSKANQAFCHALQISPTHARAWESWGGLCSMLGAVAEKQVDLSTSKGGHEGSKEVGTDSSKRVAQYLAQAMGCYLESIQLDTNEWTRIHLAKCIWMLTKDGGTPGVLCSTFENRAARLPPWVWLPWLPQLFTCLYRPEGRAIRTIFSRVLKSYPQAAYYPLRAFFLERRDVERTKSSSSTEPGQHNGSASYSEEMVSQLRRAHTSLWSSLEAILEELLMKFRPSHEEEFLATIVALLERAETQTATIGTKDEETVTASVWKTLGRIAVKYFRHSDSSSDRKDTRSIKTAEFKSQHRKSFEDDFHVSSSETVESDSSPPPMELIEILLLIKSWKAKVESHVMSTPRSIPLITSSPSLAMYCIGDAPDLWPGSCDSRYTSQIANDCKTGSAADEGNLLTSTTSSAAAAKKAALAAAKAVSICATREGVGSDYGGGSAHIEIPGLYMPNTTCWTDTRPSPELHPKLARFEPFVKVICRNDQLVRRIGMIGSDGKTYRYLLQCALPYWTRTDERTAQTYYALDKVLRKSMPSARAHLSAQPHPVVPVAQRLRLVHEPESRFSLDEVMGKSLREKISGEAPASWRFNEALKVALSNKDLATQKDEERSAFERSTRLEVFESFSKECDVDSQILSNYMSRKLQSPEPFFQFRRTFSNQWATNCLLQFVFHISERSPGKVVGIETDGRVLSPDFRIRYNNQGALEGQPVPYRMTPNIENLIGFPLMDGRFITSMAMMAGAIREYKEDMDPIFRLLMRDDLVAFFTKSMAKSDNKTQEMERQLVDRVSQNVATVQSRFSECSPKLPKDKKEGLVDQRVRELLDAARSKDNICMMNGTFQGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ42</accession>
    <name>B7FQ42_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_8678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177328.1">
        <property type="nucleotide sequence ID" value="XM_002177292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ42"/>
    <dbReference type="SMR" id="B7FQ42"/>
    <dbReference type="PaxDb" id="2850-Phatr8678"/>
    <dbReference type="GeneID" id="7196194"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8678"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQ42"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="64"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="218"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="47773" checksum="1B2AC5393F939006" modified="2009-02-10" version="1" fragment="single">KNSLSPKWTAHFDLDYEIGVLNRINVSIFDEVRKGNNKQMGTAMFEVGEVLGARGNTKAKKLKRGGTIFVRITKAPEQDAGELRLQLRGIKLKNVDGFMGKSDPFFELSAKVDSAGGLTWQPVYRSEHINNDLNPKWAALTVDLNRLCAGDLDSPILLSVWDWEKNGKRQSMGSFETSVNGLLSSVTNGASGSAKTVDLAKAFVPSFVDYLTGGCELEMCVAIDFTGSNGDPRKPGTLHYIHPDGQLNDYEKALTAIGSIVDRYDSDHKYPVLGFGAKYGGVVQHCFQVGPSAELDGIGGILDAYRQVFRTGLTMSGPTVFAEVLNFAAASARSRQDEARRSNRQAYKVLLILTDGAVTSVEETKHALNAASDAPLSVVIVGIGNADFSSMQFLDDFQSNGESGRDICQFVEFSKYKHDKSMLTRETLDEIPAQLVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQI8</accession>
    <name>B7FQI8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_43071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176880.1">
        <property type="nucleotide sequence ID" value="XM_002176844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQI8"/>
    <dbReference type="STRING" id="556484.B7FQI8"/>
    <dbReference type="PaxDb" id="2850-Phatr43071"/>
    <dbReference type="GeneID" id="7196859"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43071"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371108_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQI8"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="9">
        <location>
            <begin position="318"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="750" mass="82951" checksum="A102413915176CBC" modified="2009-02-10" version="1">MPYPTGNPTNKHMISSPSMPADGTLQTSYGFSNTPDLFKALEDGAPSNLKRLGDVYSYADGPSPPLSRDFLVVGFADTALSVVRKLVGDDDDDTPPCLQKCLISSKRMDGSYAKSLRPKDMENSKAFSLFMRRLKKEGVVAIIAKDKYERFGILKPSESIHPEGELTADDFFGICYVGRVEPIKDFLAKGIRAVVDEAIVDESSVLWKPTGVMATNNGLWQPPGNNEDTGADPFSWKPPDGDTNGLSSGNDFEATFQNTWDTVESGVGNVLSTKRKRKDNEEHGGANNENDFHSNAGAAAADEFYSKLTRSLDTRAESRLFHMRSFNGWVKATQIQELDPRTKPDRGKAGGPMRVLDLACGKGGDLGKWVLHARGISNYVGSDVARGSLRDAAVRARQIRQKLKRCTFICADLGSDVPGRLKSPNSKYMQKLSMWSLQDESEHETGTPEFRMLRGGGIASNEKFDVISIQFAIHYMMQTKQRAQRFFETVSQLLEIGGNLIATTIDARVVIAHLMNLGLDLHFDESRNSTMDQEAIIEVGGGACRIQFEPKVVKRIFQSQADSSTCVDDLFGLEYSFTLVEGSDHAAGVGNAVNLPEWLTPIPALKCLAAEAGLELEYVQNFHEFFAIRNDPNTHTAAHSALYNMKVLNRNGSLSTEEWEISHLYCAVKFRKVSESTMKLDDIVEEAEEEDEIAPLRLKQIDPLVKAKLMPRAMREAKQNIGNEAWLKLSAEEKKHVVDVSIEKLVLECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQP4</accession>
    <name>B7FQP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177441.1">
        <property type="nucleotide sequence ID" value="XM_002177405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQP4"/>
    <dbReference type="STRING" id="556484.B7FQP4"/>
    <dbReference type="PaxDb" id="2850-Phatr43118"/>
    <dbReference type="GeneID" id="7196735"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43118"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371110_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQP4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="481"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="757" mass="83388" checksum="FDBB3A535BFE6EBF" modified="2009-02-10" version="1">MPHYSFDAAAFLDQCLKAIQEVIDAEHSSRRTHPALTDLRGCLLTTEHLLFEHFQFLLERERREVSSSKTVHSLLCSRVYPSNLQSLVELLKRILQEKQALDQEHPEQAYVYHQQDQYRSYYQSRNSIDSLLFRLVVILQLCLVRTDDARNSTNFGRRKDIALTNTPGYFSWWIIATVGFAGARTAATAFPRTLLAIRGAAAREGVTIVQAVGGLVLLMSSANAIRKRWGKLWIASRIANSSESLQEWNQQWAMLQFNVSKDDKSSNAPSSSPTLPAFDTCKTQKLVRYAFRDTPWASFWHSQGELRFMMLKRAMDVFYASVGTAITYTGKSAGSDRGKWQLTIASAAAASFYSLIGANRKAHEVTSSSDSARSLIQNAWGMVSLPAIKSLSLQASRLIKGASVADRIEICGVSCFILSKEPAPELAAAIRRAQRLLGRRKMQSNALSTIDEGTEHNPDSIQSPKPFAASSDRHRQRDVIFHLTGGGFFAHIIASDLPFLLDWSAATGAVVICPEYCLLPEHAFPDALHQVEDVYRSLLWGDSVKSLGFEVNRIVVTGESAGGNLAAALCVKICMERDEIHTNVSMTATGGKRNVSDTSMDYIEKETPPSLRLPDALMLSCAVLNLSLDLTLSRVAGTDDPVLPSGLISAISDAYLPSESGISKKNPLVSPIYAADDCLRRFPPTLLFAGSNDPLLDDSVAFNKKLCYLGVESELRAVANLPHAYLGLGTAGFPEAQQVQQECRTWLSHKLATESAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQU3</accession>
    <name>B7FQU3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
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                <person name="Wyrwicz L.S."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502T0G0">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="PNRC-like_rgn"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
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                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
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                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="86"/>
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        </location>
    </feature>
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            <end position="168"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="193" mass="20989" checksum="5A053EAFF518DEBE" modified="2009-02-10" version="1">MLRNHILSKTCYRSLVGRLSSVGVSPTTNVIRTVENSLVLRSSLATPKFSSHSTPKNANRDELYESNFGDKLDESDFLEFGKQATIEKKIPQGSKDNTEETDSSVPSQTNPVERTIKEAKAMGQKVVGKAKDAASAIKKNMQELSTPSASVSGSSSRTLSEEEVKQKTYTDAFDESDSIEIGKKATGKIAKPK</sequence>
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    <name>B7FSB3_PHATC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Verret F."/>
                <person name="Berges J.A."/>
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                <person name="Jorgensen R.E."/>
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                <person name="Kaplan A."/>
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                <person name="La Roche J."/>
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                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
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                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
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                <person name="Armbrust E.V."/>
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            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CCAP 1055/1</strain>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="HEAT_type_2"/>
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        <property type="entry name" value="SSU_processome_comp_20"/>
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        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="4">
        <location>
            <begin position="1862"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="2483"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2890" mass="321935" checksum="F79DC678023C090D" modified="2009-02-10" version="1">MESQQHVKTLQTDKRSKNRLKYASSRKRAKTATADVYRSYKRRIGVTSAASREERVHHSDAAINNRRKNSTYKSIATVVPSSSTNSQSFLDDESDHPDIGTAESVLAIELDVSLDRNASEIFGKLHRELWPLVRSLPEVLYHKAMIVDILLAYLLSPESAPEEKSPVSIGKEKIPYRVNHGTTDVMHLLAVLARDVRHEIHEFLPQIVHRILSDLLNRPSPEADTGKQPIPLDVTIVEAAFRTLSYIFRYDAERLLSTIVGKDQEPCLEDMRQYYGLTLAHRRELIRKLAAQSFAPMIRQISSNKGQKRHIRRVLRALQASADSATTIAAQKLRSDAVDGIASLCFEIARGVPGRIHSKGVFVIKCVLEALIVKKCSAKAHELIFGVASSLVERLLYHLRGADVVSLLDDVVAVSEQTLLSHAFSNDNVHSIRHTIELVRKVVQHRDGIVVRESPSAERKLTKLLDFAMRATTYSMLSDTSREAVLELLSAAWRAFPDYENFAEEMSQKLSIVLSISSADSAGSGHTVSNCELSITRTPASVLVEKLMPFLPIDVSMKWIGSAFLSSAASVAASDVRLALFLVHAVATVRTVSNGSTETFVDESDEILFLDNAVHCILSEVERSTLLGLCLSRLSMIDNSNCWADVVVSAKCVAFLGMVGGGGNGRKKFTFLYKKIVKSLVGVLNHVDSAGLLSGGHTDQDSAGILFSIVLESLSKFSTASLGIAEQSDVEQVLASIVNVSERYLLLQKDSLWALKGVASFTSALQQVGLPLSWNINPLFECLVPSLQDSCHFRRIHALQILSSFPKRPFVINHSDLDFGDELDEEPPVTFAKMHEKMSVKGPTGPCDIINILKEIESTQMDMSNERYILSLISRVAVLGRTGKMPAMYALAAASHLVGMFNIKFSPIWNGSITALAALTLGHEDCVWPPLHSKLADLMNSPVFKVASDTQQTVDTSYPLIDSEMYLKRCLQWEASNGMSVSLFGGEAAFAKEQGQVSRHQSTDQSAVLRNVWAVVAAAPQLMMRHSRVMVPLVLDFFHFQYFKVHKGAHDAWALRLHEHAENSPLTYKIECLVPYDEALKATLSKGGLREALLHFQTLFESGAVAREHRFDLICLLSRVLIGRLLSQSGTRSSKDTPATRRVAVLSFLSNICSDDSDLHPFMWLILRNYIPRQFEIDPIEGNEMQSVESALFVEQLKSVTVDSCSSMPSTVHQGFLNMLEPIISYLGHRIAFYVPACTSIILILSKVYQVQPPTTGTKIDNADIVALSDRDGGRASTIRSLCHRRLSELFVQFSGVVDFSEHADCLWEAIKNALALLPEMASSSLKPPSLLLLLESISSDPLLVNLFQSRGEVFRSAIYCLRPMSNVPVVETTLRIIRNLMNSENIEGKMLISENIATLLERFESRFRSFGNIMVQTWRSELDILCEVSELIDTTTFGMGTVRGNLAEQLCSLLLPFLDVSRACNDIERLKVIKIMKRMVSQLSLEASASYYTSVGGSFGPYKSRPGISSKESRFSLANFLETLSCQRYDKAKKACTVLVRLCAVNTRRVDEIDQESIVSAMTQLDERGSPFSWLDICQDGSEPMILIPLVNTCFHYFFSDDGIVARSAFKCLKGLVAISARKADLGNPSMGDSSHTEKWRRLLEGTILRHSKEGLAARNVSVRRFFILLLSDIAFACKHSKSPNHYGDLCILIRQDEPDLDFFRNITHVQIHRRCRAFQRLRKSLGEDEEDNLGFRHHTLSNILLPLAMHPIYESKTKLEESFALEAIATVASISRLLSWSKYSSTLWTALTQFERHLDQERYIIGMICAIIDGFHFSVSLDDEFDVDNEDSTGSAVWRALSTRIMPKVEALLTKEKIDKNGTKTKILRPALILALLKLCKKLPARVLKRNLPRFLAIVCDALKSKESDSRDLARSTLSKMVLDLDIIYLGDVVRELAITLKEGYQLHVRAATIHSILLELSKVYSPPKQREHTDALPIAFDRAVPALMDLIQQDLFGIAQERRDARGSQVRYVKEAGGSKSLNSLELVSSMVLFRPSLARACPMNTSKSSVHVIVSPFLERLRSSDVSSAAIPRIRECLTRIVVGLARNTSLSVDEALPFIYASIHPFVGDHEISAGVKCVEGDSDDDNVNMSTPIVVSGSKRIRHTSQMTSLGNVVKWHPSSRNARTSTKAAHKVKASDERALARVVDGASAPKMTGSFRHSSRIARMRGVNDPASVAAVSVGLQLLYSTLKILPSDTESTLSSALDPFAPLLTKCLCTCRDSEIVLATMKCLGLFLRLRLPSLEQCSKILAEKTLELLTSTGASSFDQELLQACFKMLTFLMNFDGNGGDFILGARSSGSAAGAGVLPLDQEQMQILLSFLKSSIIDSDQHNPAMGLLKAVMSRRFVSAEFYDLMDTLLEQSVRSPKPSLRQQSGGIFITYLLQYPMSAERVTQHIKRIVLNITYEHPEGRLSAVTLLLNVIERLPVPVLESHCQMLFLPLTMQLVNDESKECRETLKSAISVLFKRLPNDLLQTLLEYTSQWSDGDTALRQTSFQLYSIFAESRVDVIVRGDNTSVLLNKLCSALEDDTDWKVVYFALLCLSRMMGSLKIVLIENSHLWILVSACLTREHPWVKLASARILSDHFASLKPCSFVEDGSISFLIEKKGSLFQTARNFCRQLDFEETEYSEELTTICIKALTWILQAMHTYPDLCYADGDDTAAGRDPVRWLVARLSNTAKPKGTKRRQSVFKCFAAFATYCSSAFLNHLEMVLEPLHRSEMESHNELNYSSMLRNDDVVQGRYAEESSLAKDVLSLLEEQWDNGIFIKAYSAVKQRALQKKEKRKLTTRTEAICDPKIVFPTAASFIFAMHPFRRRVNDAIILGSLLVEKGNSLANAHYMSKMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSC2</accession>
    <name>B7FSC2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177638.1">
        <property type="nucleotide sequence ID" value="XM_002177602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSC2"/>
    <dbReference type="STRING" id="556484.B7FSC2"/>
    <dbReference type="PaxDb" id="2850-Phatr43471"/>
    <dbReference type="GeneID" id="7197176"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43471"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357343_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSC2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852576" description="PROP1-like PPR domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="548"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="785" mass="88280" checksum="E29FE794C53E53A4" modified="2009-02-10" version="1">MRHSGVATTALGLFALPGARPFSFSSTGTYSPQTFAPCCAATSRRNSATCNNESFQADDISLLDSMPDREFKTSTPSKGDISELYLSLSHFIDMMDKAPPGTLQTEEIRLLREMMASIAEENEGHVDTMERLLYRMISEWGAATQNMRDDRIILLEPKLEDFLLVFKAWQATLETTLRSKTSSGKLNTKGLSVTVERVWRLFATQKSLFENGLESVKPDQETFRTVLSVFSVSRDRGMDRKVWSLFEAMQSSYDVEPDESIYNFVIRSLAKSRQRGAAERAENLLREAVKQYPPWMDVKGRVRGMSVESFNVVLTAWAKSGLDYGAERAEKLIIFMDEVDSANGSPGTVKPNISSFTSLIDAYAQQSEWDGVAAAERILNRILDFYLEGEAEFQPSIATWTIVLSGWSRLSRKGNRGAASRADRLLKRIESLHQEGRIEFEPDAIAYVTVMNAFCSSKTPDGPPRGEDILDEMNERFMDGDDSMRPSAKSVRMVIDAWVKSNGPGCMEKAERVLDRYEDHLASSGPPDEPHGTFEDTTEIYKILLFGWAKNGDPERAQDYLLDMVDKNMQLDSFCFDKVIEANTFLNGQDSLQRSTQVFELLEKARKTGTIKPNERVYTSYIRAIAKARVPDVAEKADAVLQRMQDLFAEGNRGIEPTVFTYNAVLMACSETPNTEKASNASAFKIALRIFNEVRGQRRGPDHVTFGNMLRCTNLVPKGDQKDKLVKATFQLCCKTGWVNSFVLRDLRDAASAELLESLFSQSLDSLDVEQLPASWQRQFANKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSK4</accession>
    <name>B7FSK4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_9962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177680.1">
        <property type="nucleotide sequence ID" value="XM_002177644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSK4"/>
    <dbReference type="PaxDb" id="2850-Phatr9962"/>
    <dbReference type="GeneID" id="7197573"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9962"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410218_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSK4"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="180" mass="20299" checksum="4E769FAD42523126" modified="2009-02-10" version="1" fragment="single">GVLTPALMESLRGFFPYGVAEENFWLKFSMERDGAHLPTLLSKVRTSKHTIFGVETKSGHVFGAFCSSHWRVRPSWFGSGESFLWRLKASRAVPDSTTRNYDNDNEMEVYPYTRSDEMIQYCTEKTVAVGGGEFRIGFMIDGDLMGGETSACATFNNPSLGDRKSRSNEFEVVHLEVWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSL0</accession>
    <name>B7FSL0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177683.1">
        <property type="nucleotide sequence ID" value="XM_002177647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSL0"/>
    <dbReference type="PaxDb" id="2850-Phatr43545"/>
    <dbReference type="GeneID" id="7197219"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43545"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509501_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSL0"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="557" mass="63028" checksum="8EDD3B1C9F523510" modified="2009-02-10" version="1">MTVRQFNDHSDGDKYQNYSGPRMDLPSNFLTFLSDLKCAVSKSQFVALNENLENLWNLSPQEQAIDNQRQVEEDVAAVDKNTLIAVTQHLISTLCGILKDGTAFGHQSQDSITTTSQPIDVLNAWNQHHESLCLDDTEEPFLWFTEIIRASKNWVRWILQIYPMIAPSNSVSYQATQPFQSNEMLEFYMLLMDGYISLKFVNAKTGENLARHACQLLFYAVYSQSPRTDDKAQLRFQHLRELDFFDRILTMLGQAQTTAFGFALVQLIHNVMYSFTDASKAWTESNIFLTATACSKCPWLSQKSSEHYTFPIMLEYMLIWCLSSQPPLPNNFEDRRVNIVVEVLRTFYAMRAGSKLTVDSALANILVQLLHLDSQKKQCMDCQIAAVPILMDANPSLGDFLVSRESVAPLMHILDSQMTLVLRSNEMDNAGAAKLTPILAVLFRFSQANLKFRQLVKASIFPRDRETTFQAMVKEAEKGIGSTKNMTPMDAPSGTLRAGLIRLLSWPQSHIKRFVGELLWILCANDSKEFSYRVGMGNALPFLGLKGIVELPPTIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT67</accession>
    <name>B7FT67_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_50738</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="11"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178103.1">
        <property type="nucleotide sequence ID" value="XM_002178067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT67"/>
    <dbReference type="STRING" id="556484.B7FT67"/>
    <dbReference type="PaxDb" id="2850-Phatr50738"/>
    <dbReference type="GeneID" id="7197243"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50738"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_2_1"/>
    <dbReference type="InParanoid" id="B7FT67"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000759">
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        <property type="term" value="F:triose-phosphate isomerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="TIM_sf"/>
    </dbReference>
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        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854986" description="Triosephosphate isomerase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="290" mass="30153" checksum="0184C11E9F373467" modified="2009-02-10" version="1">MKFLALSVAALISSATAFAPTFRGSPASTTASTTSLAARKPFISGNWKLNPQTKSEAVDLASNIAAAITSDSPDADVALFVPYVFIEAAQEATGGKLAIGAEGVCPQIQGAFTGAVSASMLQSIGVQWALAGHSERRVVFGETDEYINGQCLKLIELGMSVMLCIGESESEYEQDLAGPVCAVQLKKGLAGIQKEDLSRVAIAYEPVWAIGTGKVATPEIAQSVHAKCRAVLAEMYGPETADATRILYGGSVTPESVDDLMAMPDIDGALVGGASLDAAKFGRIINFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU43</accession>
    <name>B7FU43_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178534.1">
        <property type="nucleotide sequence ID" value="XM_002178498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU43"/>
    <dbReference type="PaxDb" id="2850-Phatr44440"/>
    <dbReference type="GeneID" id="7197681"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44440"/>
    <dbReference type="HOGENOM" id="CLU_786354_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU43"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="353" mass="40579" checksum="D82D0B379A1A7681" modified="2009-02-10" version="1">MDTQIADIFGSIRESHDRKNLEKVQQDEDSPYLKIKFDRVSYSHHIPHDGDERGQIRKKLYISNVASENQKILPQREIREWAHDATGVDRELFFEAKSMDFKPRRQVKFFGSKITPGITSPEKSKAVKIGKSFKNSTSRLVVKGGKIVKEEAKVSHIGENTETFSKQCKSSIKHGGLTNSNPFSTERHYKKDQLGDSDGLFFVAEDEKIIEQARFLDEMTSPTTQVREQTPDKSSQETSHQSILDKLENEERLNWKADMTAIVFNDAHSSKLPHFSSRTSVIVHDGMLIKTKDVPTYRLSQTQSRDDWVGPTVINNKVRKKEYESENNEKREMKKKKAKGKDKQGKTEKRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU98</accession>
    <name>B7FU98_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_44482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178557.1">
        <property type="nucleotide sequence ID" value="XM_002178521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU98"/>
    <dbReference type="STRING" id="556484.B7FU98"/>
    <dbReference type="PaxDb" id="2850-Phatr44482"/>
    <dbReference type="GeneID" id="7197713"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44482"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_5_1_1"/>
    <dbReference type="InParanoid" id="B7FU98"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="600" mass="66314" checksum="3AE321115FA9BDBE" modified="2009-02-10" version="1">MLSKKVLSSFQKSSVGACVLSGTRRVSTAHVRCVSVAALSHFAGNDNASLSSKCSLMNVAAAAAAATATILTWAGATSLCDSNAKPMSTEDSHLTPSEVGKEDFEEFQASHDINSMPVYSLEEIAEKNGENGNPIWMSYGGVVYDVTDFIPNHPGGSEKILTAAGSAIEPFWYLYRQHFASDLPMRLMEHMAIGRLSEEDQERIEEQMATLEETDPYAKEPYRHRALLVHSDTPMNAECPTRFLTQNFLTPASIFYIRHHHPVPFLSEKQVNDFRLKVDLTAYGKGVVLYSVDELRKMKKVEITATLQCSGNRRSGFNQFQRTSGTPWGQGAISTAKFGGVRLTDLLKASGLKDPIEAEEKLGLEHVRFHSLDGMSASIGMEKAMNPYGDCIVAYEMNDEPIPRDHGFPLRIIVPGYAAVRNVKWLEKIELAKTEAEGPWQRGLNYKTLPPNMTNAKNVDLNKMPSMTEVSLFSGITQVEKPEMKEGMKAGDKITVKATGWAWAGGGRNIVRVDVTGDNGASWATAILKEGSEQRFGRAWAWTFWECDVPAIVQEDGNVHLASKAVDLAFNAQPEDANHTWNVRGLGNNSWYRTKIRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUG9</accession>
    <name>B7FUG9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_44549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178592.1">
        <property type="nucleotide sequence ID" value="XM_002178556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUG9"/>
    <dbReference type="STRING" id="556484.B7FUG9"/>
    <dbReference type="PaxDb" id="2850-Phatr44549"/>
    <dbReference type="GeneID" id="7197794"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44549"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_0_1"/>
    <dbReference type="InParanoid" id="B7FUG9"/>
    <dbReference type="OMA" id="RPFNEAY"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855022" description="FAD dependent oxidoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="443" mass="47675" checksum="00255B72F40EFB5A" modified="2009-02-10" version="1">MKFALQRRPLGSGRKAVAFVSWSCLLHTTTLAMTVVPKNVVVVGGGVQGTSVAYQLALRTPASTTITILESQQPASAASGKGGGFMARSWGDGSPTQGLHELAFDMYSDLAQTLGCESYRKLPVLSVSPGYNGMKAARKNKDLAKIIPGWLDGTVGRVGSMGGGEDTAQITPQEFVEKMLEHQSRIQVVLGTCWGVETDQGSERGSRKVATVEYNPKENPAEKKLLPADTIIVSAGPWSCAAEDWFHGAVQLPMEGIKSTSIVWKKPEGNDVDATALFCGEDDRFGTHLEVYPRPDGTIYICGIGGSDYVSKEDLKEGAFREICEANELRVAAAKASFQEMSSVYKTSGELDRSQACMRPCPPDAMPYMGSVPGYEGAYINAGHNCWGIAWAPACGKAMAELILDGESRCVNLTPFDPARYTPDAQRGTRGRKQRGNNVGEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUV5</accession>
    <name>B7FUV5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178386.1">
        <property type="nucleotide sequence ID" value="XM_002178350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUV5"/>
    <dbReference type="PaxDb" id="2850-Phatr44667"/>
    <dbReference type="GeneID" id="7197653"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44667"/>
    <dbReference type="eggNOG" id="ENOG502SMBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056661_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUV5"/>
    <dbReference type="OMA" id="FDEDICK"/>
    <dbReference type="OrthoDB" id="38217at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855358" evidence="2">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="399" mass="44169" checksum="75E0174A17DC1FF8" modified="2009-02-10" version="1">MKFRILVLLLVPLFSLARAVPEISVESDLGQHLLANARRVQEGENNNNNNEAITFEWVAGYSVKFQGCHVVKQWNDNANNENDVRISSQGLVRFRLCPSSQCSANKASGCSKGYGDYVIGMSEFLSSFYEAKSREIEYDCQYYLQNKCSCQDTDDKDDGFNADYCEYDCFNNSGMTECVDRNPYQDDGQNQNQQFNLENYMQCTAVRLNNNNNGGGGQRVLEQNGASYYVGPYCSEKGGSIYLGLFTDDSCTNAATDTTFQTLVGFELPYSTSSIVGADCVSCLEREYNQQDDQNNQADANDAADIDAVSESCETLYQNAGKCENSLASGIVDDPNTSACTYMEGIRVVRQDGIIDTGSSRSSAVATALIVIFAMAFCAMAFYVWYLRTRLGVKQNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV65</accession>
    <name>B7FV65_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_6725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179086.1">
        <property type="nucleotide sequence ID" value="XM_002179050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV65"/>
    <dbReference type="PaxDb" id="2850-Phatr6725"/>
    <dbReference type="GeneID" id="7199660"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6725"/>
    <dbReference type="HOGENOM" id="CLU_601985_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV65"/>
    <dbReference type="OrthoDB" id="44621at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="168" mass="20269" checksum="DE863B1630E7F8D3" modified="2009-02-10" version="1" fragment="single">WERRYEELCAFHAVNGHCKVPPSVPHLGVWVRNQRREYRRLELDQDSTLTQQRLDRLYALGFEWCTSHSTKWESRYQELETFYREHGHSNVPEDYQGNVSLGQWCMNQRTAYRRYANGEPTALTAERIELLETLEFRWHLRLHQWKCMLERLKLYHDAHGHVAIPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVB4</accession>
    <name>B7FVB4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_5543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179109.1">
        <property type="nucleotide sequence ID" value="XM_002179073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVB4"/>
    <dbReference type="STRING" id="556484.B7FVB4"/>
    <dbReference type="PaxDb" id="2850-Phatr5543"/>
    <dbReference type="GeneID" id="7199686"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5543"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724557_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVB4"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="141" mass="15315" checksum="75A493BBC277A8F2" modified="2009-02-10" version="1" fragment="single">QWWRLLTPILLHAGVIHLLCNVAVQIEAGAFFEQEWGSFRWLVVYLASAVGSSILSIIVMPNAVSVGSSGALMGLFGAKLAEVTLRVCDRADTEQQRVAHQVRKEQCTAVTCSVLLVMLFSFIPYVDWAAHLGGLVAGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVI7</accession>
    <name>B7FVI7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178713.1">
        <property type="nucleotide sequence ID" value="XM_002178677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVI7"/>
    <dbReference type="STRING" id="556484.B7FVI7"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="PaxDb" id="2850-Phatr11236"/>
    <dbReference type="GeneID" id="7199876"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11236"/>
    <dbReference type="eggNOG" id="ENOG502QQ01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FVI7"/>
    <dbReference type="OrthoDB" id="41505at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472">
        <property type="entry name" value="DNA REPAIR PROTEIN RADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472:SF10">
        <property type="entry name" value="DNA REPAIR PROTEIN RADA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13541">
        <property type="entry name" value="ChlI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Zn_ribbon_LapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="104"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="52610" checksum="9925FC0793970B24" modified="2009-02-10" version="1" fragment="single">MGTSGSSTARIHICGNCGSEFVKWMGRCPTCREWNTLQEHAVRREPASASRPVFGTNISSSGARPASWLDGIPGSLGSNAPVRITDLVSSDDGSTNTLSRLHSSQRVTIPNDDELNVVLGGGIMPGSLNLIGGDPGVGKSTLMLQIAGAVASLAIPTPGIGMGLPDSNNTRTKSSTDGTGGPVWYVSGEENPDQIASRASRLGILQSELWLLGETHVDTLCQQVVVHAPALIVIDSIQTMVCDSGGSSSAGGITQVRECVALLLRLAKSTRIPIFLVGHVTKNGDVAGPRTVEHMVDCVLYLEGSAHNDGLNLRMLRASKNRFGSSDEVGVYEMTAGRLLPVSDPSSLFLAHRVTQEDAEGCAIAIALEGMRAMTVEVQALATPSGSTTGYGRRTVEGIAMSRLNLLIGVLQKRCGVFMFKQDVYINVAGRIRLDRGEGNAVDLGVAVALVSSLATIAVRSDTAFVGEVGLLGELRSVAALPKRLAEARRMGFSRVITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVQ8</accession>
    <name>B7FVQ8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_19329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178974.1">
        <property type="nucleotide sequence ID" value="XM_002178938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVQ8"/>
    <dbReference type="STRING" id="556484.B7FVQ8"/>
    <dbReference type="PaxDb" id="2850-Phatr19329"/>
    <dbReference type="GeneID" id="7199762"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19329"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="InParanoid" id="B7FVQ8"/>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="338"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC49672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="597" mass="64725" checksum="BCC717DB58D700F6" modified="2009-02-10" version="1">MQRSMLYRTFVPPVFRQRTSPTPACASFRRPGFFSTATGFLERNITYDSPKTFNILPVLKGCDLDTRSDVVRCALSRTQHDVELLNERLAHVRLGGGPQAVQRHVSRQKLLPRDRIECIIDPGTPLLELSALAGFQDDIPSGGIVTAIGIVASQPVMFIANDATVKGGTYFPITVKKHLRAQEIALQNDLPCIYLVDSGGAYLPQQDQVFPDRDHFGRIFYHQATLSSRNIPQIAVVCGSCTAGGAYVPSMSDETIIVQGNGTIFLGGPPLVQAATGEVVSAEELGGARVHTTVSGVADHLAVNELDAMRLARDVVASLGRAPSGITSTKTTSEHLPQHEEPLYDPKELGGIVPVDSKQPMDVRLILARILDGSRFHEFKKNYGTTLVTGFGKLMGQDVGVIANNGILFPESAMKGAHFVELCCQRGIPILFIQNITGFMIGQKYEHEGIAKHGAKLVTAVATAAVPKITLVVGGSYGAGNYGMCGRAFSPRFLYMWPNAKIGVMGGEQAANVLATIQRNNIHARGDQWNAEEEASFKQPILDKFEKESSAYYSTSHLWDDGIIDPADTRMVLGSSLAIARRVGCNPNATKFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW76</accession>
    <name>B7FW76_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178835.1">
        <property type="nucleotide sequence ID" value="XM_002178799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW76"/>
    <dbReference type="PaxDb" id="2850-Phatr44949"/>
    <dbReference type="GeneID" id="7199844"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44949"/>
    <dbReference type="eggNOG" id="ENOG502SP6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326107_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW76"/>
    <dbReference type="OrthoDB" id="45872at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="866" mass="97263" checksum="BCC52A8FA8B84A99" modified="2009-02-10" version="1">MSSRRGAAQARNALQGTKGLPPSHPKEQSASHRAFLIRSLERNDAETAALVDLHQTLVRLRQRIVDTRPHGAAFLLALGRGTLRLDPSGNDRLEHVAHDDDNHHHDWFANTSPTLRRLGVEFLLRRKLRRQLLNRLARRLNRIAHVMDGEDVGVPALPKYGELRLHVQDDAVAALVAHWERQDQARIRIQAARETATNLSERSVGAPAPLPQQQACGGGANEAEPRDEHPVKVEDPSDTKETPVDATVPTPAEHGPSTAASPHPETHASITPAPHEADPVPSDTDPSDAMQLDYEAFRDYKDVYDKVWNANPVGNQPPGFAYLAAAQPIDEASFGVTAVAGVNATNRHMTLKEKQAEFMRWQTSLLAKIPDQPTFADLGLDNRVFCWEQRYQQAWQEATEDNNHTSSEGEDARDPQQSPQKVNEATDSGSAKKLRVVKKEDHSDDDDAMEVESDPATDEKQETKSPTKTVGKEDAKLETPQKPERKEEEAKEHARKIVKPISLAAVPSFYDQDLERIKWVHAELMSTSIRDHARQRIHEVTKEYNNALRVSNELHDRRQRAESQYQMFAHESRNQLTKIKIEYQNDFAVYKSRYLQRRREFEQKKLAQLLPSKWGRNPEGTHATRLYTARPNAIANQVGSCLADVVDAVDLVAQGKLTLTKFQEPFNPPQPPNIQGAIDPKTGETITQRNKRVEEGLKQEVNTLALKLRNNEEERQKAWRRMLKTKAEFDLPHQGTGSSRAQVRVDLNNYHQVALPPLRQSSTQSVPQEVAARVAVLPSYTPVQSQYYPMGGGDNMMTMMESSKYSAARVKERISADGTVAPVTEPKLNKDGLYLRPAGRTRKGMEWDAVRGIWVPANNNPGGYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWM5</accession>
    <name>B7FWM5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_54355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179187.1">
        <property type="nucleotide sequence ID" value="XM_002179151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWM5"/>
    <dbReference type="STRING" id="556484.B7FWM5"/>
    <dbReference type="PaxDb" id="2850-Phatr54355"/>
    <dbReference type="GeneID" id="7200204"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54355"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472106_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWM5"/>
    <dbReference type="OrthoDB" id="43314at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="235"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="497"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="667" mass="71152" checksum="BCB8F496CE1F8466" modified="2009-02-10" version="1">MSSEDGDEGREVNVSEWIANAIADTGCRVVYGGHGGALVPLVNAVSAHPALRWVYARNEHDAATMAAAHAKYTGGLGCVIATSGPGATNLTTGLLEAAWDKVPLLAVTGMKPTSVIGYSEFQDVNQSRLFAGAGIEWSKDATSADSAIPLLRDAVATALSRRTCVHLAIPVDIQAAASPLKLKHFCASHANVGLRPPRVDAEYVHQAAATLVGVPEERKPRNVIAVGLRARCHGIGGDVHPDISKAILELAEALNAPVLTRLHAKGIVDESHPLSFGVIGVHGKPGLEKAAALISTSDRILSIGVEDETLLLCNAAGLQIRKLIEIQPDAMAVGTRYNAEHTILGDIYEICTQLTERVETLSVKVEKKRNLVAHQRDPNNGLHNHRRENTLEEFGYAAFGNPDAVMDENEELTLPALKETGPDEMRRRTDRLWQAMHAANWKELAKLSDGPIQFECDSAPDSDGYCHPASVLQALSDARMDCNGTDKVSREAVIAVDVGDVTLWASLCLRLTAGSRTLYSEHLGTMGYALNAAIAGILARDGPAGAVVLSGDAGFQMTLVELATFQQMKRDGDKLLCVVFDNQVMGRVAFGFENAAGCDVGGPDYVALAKAYGGDGVLLDDSRKAPQVVRDALIKEGLYIVHVKVDPHVKADMASFKDNSLKVMNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX11</accession>
    <name>B7FX11_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179474.1">
        <property type="nucleotide sequence ID" value="XM_002179438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX11"/>
    <dbReference type="PaxDb" id="2850-Phatr45256"/>
    <dbReference type="GeneID" id="7200269"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45256"/>
    <dbReference type="HOGENOM" id="CLU_156214_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX11"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="147" mass="16295" checksum="875994996460D180" modified="2009-02-10" version="1">MMTYGLARCGHNMNCSQGTTQCVPLAPPPAQNNSQPVALLPMPILLPKIPPSLNKNLTFDTSWLSAAQVATKKSDPVVKRNKDREETSASILVASRPSMVDPRLATFLERFDNAEWRLQALQPENAKLQAKVQEAERQKRAMQQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXB3</accession>
    <name>B7FXB3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179524.1">
        <property type="nucleotide sequence ID" value="XM_002179488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXB3"/>
    <dbReference type="STRING" id="556484.B7FXB3"/>
    <dbReference type="PaxDb" id="2850-Phatr45331"/>
    <dbReference type="GeneID" id="7200027"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45331"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718598_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXB3"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF163">
        <property type="entry name" value="METHYLTRANSFERASE SMALL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="340" mass="37500" checksum="BED008F8415E24BF" modified="2009-02-10" version="1">MASTALIENGVLVDDKDGNPDNGTKLSRPTSATARAFFAALDAQTAHSVNPTSFPLSASTSNITRNKGSTRNTTSATNTKRQPSEWMHQRIQSLGWRNRYSQDEDYPVTIANQIVKVRQVQRGEAEQTYGTGATVWPAAMVLLKYLERHSVTLRGRTVVDLGAGTGVTSIAAAFLGAKRVLCTDGEPTVVQLARENIVRTAESLSVLNTTTTAITVTTTDPMNVSVIQGCPVHTQHYWWGTGSIPDDWEVDVVLVADCVLPKLYPIAPLVQAIDQLLVKPNTEAILSYEHRYYPDYDPRDEFRTLAAARHLDVLVVPLTEHDPVYAVDDIEIWRVRRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXF2</accession>
    <name>B7FXF2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_19835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179546.1">
        <property type="nucleotide sequence ID" value="XM_002179510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXF2"/>
    <dbReference type="FunCoup" id="B7FXF2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXF2"/>
    <dbReference type="PaxDb" id="2850-Phatr19835"/>
    <dbReference type="GeneID" id="7199991"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19835"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FXF2"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="6">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="208" mass="23405" checksum="DA3C9E755BA4AF59" modified="2009-02-10" version="1">MFVVTTVFDTIRIPPLLLSMPTVQAVHSEIDQKYPNRVLMDVGLVVGRYGECARVGHGFCVSGDGGAHHECEFRLIVFRPFVEEVCLGRITKSTAEGIHVSIGFFVDIFIPAYWMLRPSHYEEKSGLWIWTPKYDDDEEDAEDEADDAASIRRRSSSVGLDENQALPPSMHIVASICEDGLGLTTWWAAPVEDDDDEDMKEEPKQEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY73</accession>
    <name>B7FY73_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_27166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="2"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179887.1">
        <property type="nucleotide sequence ID" value="XM_002179851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY73"/>
    <dbReference type="STRING" id="556484.B7FY73"/>
    <dbReference type="PaxDb" id="2850-Phatr27166"/>
    <dbReference type="GeneID" id="7200374"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27166"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_0_1"/>
    <dbReference type="InParanoid" id="B7FY73"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd12174">
        <property type="entry name" value="PGDH_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF47">
        <property type="entry name" value="HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="378"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="471" mass="50646" checksum="406BC3E1E7015D3B" modified="2009-02-10" version="1">MSALIRSVARNVALRRSAASASGRSFSSIEVDHYTSGKRNEGQGGASQPGKYAIQTFNKISPIGLARFPEDIYSVQPAEGAESPAHALLLRSHKLQETEIDVSVRAIARCGAGTNNVPVARMTEIGIPVFNTPGANANAVKELILCGLFLGSRRVVDGINHMKKLGQQGLAKERVEKDKAMFGGRELKGKTLAVVGLGHIGAGAARDATALGMNVQGYDPGLNVESALKLPRDMKLADSIASSVTNADYISLNMPYIKGTPEEGGTHGIIGRDVLAHFKQDAVLLNFARGELVDSSAMKEFLDSGNGRYISDFPDDECWDHPNAILLPHLGASTEEAEDQAAAMAADTIREYIERGNIRNSVNFPTTQLSERGEDIIRISVINKNIPGCLAKITSCIGEMDVNIVQQINQSRGEIAYNVIDLDVKTDHEGKVNLTKLQREITMLDGVLSSRILSGIRGAGYARNIDGDYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYH5</accession>
    <name>B7FYH5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_45673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179741.1">
        <property type="nucleotide sequence ID" value="XM_002179705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYH5"/>
    <dbReference type="STRING" id="556484.B7FYH5"/>
    <dbReference type="PaxDb" id="2850-Phatr45673"/>
    <dbReference type="GeneID" id="7200457"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45673"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248596_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYH5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="10">
        <location>
            <begin position="158"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="10">
        <location>
            <begin position="364"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase jelly roll" evidence="11">
        <location>
            <begin position="672"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="12">
        <location>
            <begin position="839"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="951" mass="106202" checksum="5A4E195ABA76054D" modified="2009-02-10" version="1">MKTMPSLEFRQSLKGGRPIPADELRQSLSHQEVEYGSFLPKSSTFHETELRPCSELQKRRYQRDLILLACAALIILYVSGFPPRIKNAGIFKKTSSIIPEGTTYAATTAELKNEIPACGDEPCFHPDRVQVRRDRPYFPSFWNYNGNLSVSYDERAIRINDKRVLLLSGSMHPVRATRGTWEHALDEAVYNGLNMITVYIFWGAHQSFRDEPLNWSLDGSSIGPKESQWELADALRSAANRGLFIHVRIGPYACGEYTYGGIPEWLPLQSSTMRMRRLNRPWLDAMEGFVAATITYLSSFNLWAHQGGPILIAQIENELGSGVDGSAAANYVVLERDEFNDDKHEDSHLLQLDRYGHILENASSRGMDSELRNATVQDYADWCGNLVARLAPNVIWTMCNGLSAENTISTFNGNNGIDWLEKYGDSGRIQVDQPAIWTEDEGGFQLWGDQPSKPSDYFWGRTSRAMATDALQWFARGGTHLNYYMWWGGYNRGRSSAAGIMNAYATDAFLCSSGQRRHPKYDHFLALHLVIADIAAILLHAPTSLLKNASVEIMDGDDWIVGDNQRQFLYQVLDTHDSKQVIFLENDANTTEMARLTGAKADDSLVFVMKPYSSQIVIDGIVAFDSSTISTKAMSFRRTLHYEPAVLLHLTSWSEPIAGADTDQNAHVSTEPLEQTNLNSKASISSDYAWYGTDVKIDVVLSQVKLYIGTEKATALAVFIDGAFIGEANNHQHAEGPTVLSIEIESLAAGTHRLAILCESLGYHNLIGRWGAITTAKPKGITGNVLIGSPLLSENISLVDGRQMWWSLPGLSVERKAARHGLRRESFEDAAQAEAGLHPLWSSVLFTSPQFDSTVHSLFLDLTSGRGHLWLNGKDLGRYWNITRGNSWNDYSQRYYFLPADFLHLDGQLNELILFDMLGGDHSAARLLLSSIEESETSKFSDEVDFALACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYL4</accession>
    <name>B7FYL4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_54466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179764.1">
        <property type="nucleotide sequence ID" value="XM_002179728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYL4"/>
    <dbReference type="PaxDb" id="2850-Phatr54466"/>
    <dbReference type="GeneID" id="7200480"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54466"/>
    <dbReference type="eggNOG" id="ENOG502RNAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FYL4"/>
    <dbReference type="OrthoDB" id="41870at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="693" mass="74556" checksum="846D4B166625FCF0" modified="2009-02-10" version="1">MVFGILGKCARNTSDSSGTQAPPVQLARVERSRPRRPQRTRRTYRNALQVLGTSRVLAGMRTRNPGSQRSATAKGFSCLACRTIFVQRLRGVRTMLGSRIASTTVLVTALLAWTMPETQARFTPIVTYAPMTKVTDVAALDLDQNELERQLGLGALNNARAVYERGGNSLSIANLTLVNPPGPMSYPQGTQVLGRTKGSANTTVLGILVDESVTWGALPGNVTIHVQPTPTANPVDSGPLVKRTSMVTHPLPFPLLLRVANRIPGYNDQGHVTLVPPGESANRGDKLAYKYDIRQDNWNLRTLQSLSTNADTSMRPCPGCPFYADFQTFVNYYETTEYADSWIMAAALNRSVAFPSGRGNANFGAAFTSGSKLGLAEAVKKGTAYMSVFMQIIRDLEDAMTDCDNKCDPDDLSCQDIGAEAVHSLDAAVALYAGSLEGTDGTENSGVMPYALANRRAADFRTGGPQGERSSGTAHVNYEVIKEFKHAQTRLLADECNLARQNKWRIVNLMKVPLVQGVLRYAYMRDFNNPSDAPTREKEQAEGATFAAALLPFVHKCDTADATLIYNNMRIGSDANKVVFADVKAALERNYGCMGISCPLVGGFHNGQDYERGATPCTEGTLQGPAAPDFSQLPSSSGGSGGGNAGVAVGWILAVCLAGVVGFMAYRRFGKRKNIADVMKPPANNLAAVSEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYM3</accession>
    <name>B7FYM3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179997.1">
        <property type="nucleotide sequence ID" value="XM_002179961.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYM3"/>
    <dbReference type="PaxDb" id="2850-Phatr45776"/>
    <dbReference type="GeneID" id="7200793"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45776"/>
    <dbReference type="eggNOG" id="ENOG502SE1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007416_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYM3"/>
    <dbReference type="OMA" id="DAYTCRR"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="3">
        <location>
            <begin position="387"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1457" mass="163279" checksum="813F6F874145B7CE" modified="2009-02-10" version="1">MDQQQSTLLRAIALSSLHLASYAQKDRLQAYEILETFKRFEGRLPIILGWLHSTSHFYEQYDITVATKLLALEILSAFLDKGYEKISELDRVELRRAVLKSAHLLSTNTLPEGSRILSKKLAFILENLVVRDFPQRWTTFANDVFASQQDGGLWYNEPGPQAVQHQGVRICLECLKLVAENCTDSDFNARISTTRRNDVLIGLNEVSGAFLPKMFQLLEHYPVLRQAKDTMHSMHAFLVSDNRATNQMTAEESSQYRAQKELREGTAQMISDTLLALRTFCCSMPVNWITGGSIDFLTALLHLMREPDYEIQIRAVECIEQLALRGKLDFGQWLRLVTNIPLAVQEANHLFAVEYEHLMTEDSAKGVKKHAQDPLALQLQFHRSTSRLLANVVSSHLALVTSNKSILSGNGDVYEKLMVFFRLQVDMLHHPSGRICTEQINSWVALLRDPQLSKARLLKPFVDEILKSYMNQMVKIRWEDVENELHPHSVLLAASFDDEEDFEIWMSDLRSRSSLLFKFLGSVEPEISSTTVSSTFQSILYKYGNGQPFDNVESFNSQLTQRSEAVVQFEALYQPMDTVLGGIPVWAINVEKPIPRDRLDGQSSRDGTRRALSELVQALLSWSPTHVWLKFRRAQLLDALKHYWKNGHDSSTLLEAVDSLLKYLGLPDEWNLSTVVGETMSDEIVGLKKKSGVTLVSISKQVPNQLLPWLSQLSDASKSLLSSHGLIPVNQMHLYEFLSCVASAVEDPNRRASFIAEVLSNAADTLELPEVQSSLSVQGLLETLGVSQAAALPESVTDAAHVKQITWQYYRIFNALNRLLSVGKRCNEAARKRYGSTASPTVSSSSAFDSIGSQNFPDEGPISIVDLATIDPFAPLWPRILPSFLKVYEATMAVWRPENQARLLQNPYQRYLFAISDDEAFQSKNHDQSSGGVFGESGTAGSVVMGTTRRDNNLVPKWSGWFNELRHTCFQMFGLLCTQRVLFAPELASSYPRIVAVVTDPASMKAMEHRHFIHFLKHVVELLLVSCPSTMYATHLEPILGPVFEHIKYRLEKTWLPILNSSTPPSGAAKALTSKGCSYAAALASRGGDDWFTWYYAHAGLFVGDLDSVTAEAAVEKYRVEIGRNFSDVLQVALALKGDWALVLANQAREEQAAKRNGYTKPTPQNRLNQDSEQYNADGTLKSDDQQAIDERKALRINGLCHFILLENERVAGNLTMALIQCLEYPDAYTCRRVTKICHRLLETVAWSPSYSNLLGNMMFTQAVKNLVTEPKWMVGIEWDMINVVRDIYCRLVLGQILQAGGQGPGLQQPSTSQKPDCYEQAKTVDRPLQGGGILVNPTDAPRQILLTLPGIDAIAIEQLERSMKAKPSAKDQKDFIRDLFRVAADSLNEISPSTNIGAASGLFDRAVQEESLLHSRNKASIPDLPEKLITHSQLLKAAKRQGTDEPEGLAVLLQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ17</accession>
    <name>B7FZ17_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_45886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180263.1">
        <property type="nucleotide sequence ID" value="XM_002180227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ17"/>
    <dbReference type="STRING" id="556484.B7FZ17"/>
    <dbReference type="PaxDb" id="2850-Phatr45886"/>
    <dbReference type="GeneID" id="7200978"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45886"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_1"/>
    <dbReference type="InParanoid" id="B7FZ17"/>
    <dbReference type="OMA" id="ENTSYMF"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="76"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="581" mass="63593" checksum="FA9A611159E2FF46" modified="2009-02-10" version="1">MKILASATRQFYQSSQAPSLPHKVKFAASVVQLPWDTHNFKSSLVIRSKRNYASTAWQRTQRVALPEVAGDPSIIKSAFRERLDAERAQAFLGGGQKRIDKIHARGSLTARERLELLFDNESFHELDQLKAHRCTEFGMDEKEFPGDGIVTGHGTINGRVVYAFSQDFTVLGGSLSETHAEKMCKVMDMAMRVGAPVIGLNDSGGARIQEGVDSLGGYAEVFQRNVDASGVIPQISVIMGPCAGGAVYSPAMTDFIFMVEDTSYMFVTGPEVVKTVTNETVTKEDLGGARVHTAKSGVAHGSFSNDVTALRSMRRLLDFLPASNDKNTLPVKETTDPADRLVPSLERLVPDDPNTPYNMKDVIRETVDNGDFFEIMPAMAQNIVTAFARMEGHTVGVIGNNPLTLAGCLDIDASIKAARFVRFCDAFNIPLVTFVDVPGFLPGTGQEYGGIIRHGAKLLFAYAEANVPKVTVITRKAYGGAYDVMSSKHLRGDCNYAWPGAEVAVMGAKGAVKILYGGKDVEQHTKDYTSRFANPMVSAQRGFVDNIIDPQETRRIICNDLRMLRTKHLPNIPRKHSNLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZB5</accession>
    <name>B7FZB5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_35810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180317.1">
        <property type="nucleotide sequence ID" value="XM_002180281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZB5"/>
    <dbReference type="STRING" id="556484.B7FZB5"/>
    <dbReference type="PaxDb" id="2850-Phatr35810"/>
    <dbReference type="GeneID" id="7200841"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35810"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357002_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZB5"/>
    <dbReference type="OMA" id="HWGEKLT"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21026" checksum="43F126FE64C5D69E" modified="2009-02-10" version="1">MNSTGNGEENDTGAPLPDFRTSGIQLHTVAPALGVIGKNTPDYLDYDTKGRGIIVTMFANAGMSYVLGTTFGGVYGVRQGLVATPSNRFRVKLNSVLNHSGRYGSRAGNTLGVFAVLYSLYEGLADHYDLEETLGVRDISPAAASFVSPAFGAVMAGATYYGPSGPRVAALAGALGFGSVAVTYAAYTVLGIPYGSRGYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZT5</accession>
    <name>B7FZT5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180362.1">
        <property type="nucleotide sequence ID" value="XM_002180326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZT5"/>
    <dbReference type="PaxDb" id="2850-Phatr46027"/>
    <dbReference type="GeneID" id="7201519"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46027"/>
    <dbReference type="HOGENOM" id="CLU_604793_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZT5"/>
    <dbReference type="OrthoDB" id="49307at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="48818" checksum="EDAAD1EA0DBEAA97" modified="2009-02-10" version="1">MPRRSGRLQLNEVLEESKRTADEFVVVPQADPGNNSVMDEGGASPSTVTGRKRSRQSKDDHSDGVGDDFGENDLEDSDKEEVGKEPAKPRDVTSILSKWGRKGMKSKSMHASTGTIDGSDTSPNGSSGVREGENSTLSIGRKDKAEVTKVAPDAIPKKKVPRKTNDAPSSGPSLLSNLTPGIRPPPVNPQTSKSNSSTKSSAMPSNKSTLHSQPVKTKEYTLPASVRTQHITSDSNKTGDLPRSTQESRQGLAPPNSATQAQPPTRLIASTSLPGLRVEERRLMAQLQDTCHRISDSGALPLPMSLAVDVSGSFLQNADNRFDFFDTNSNGEVVLQRPKPIFPEEFAAGMREHPLSWWGIVDPRLGENKYQKLGKVQHQAHDSEPRPSTFPRPGREMNAQQYHNQGWAGNGGGFVGGPNGRGGYRNSSRHGGGYGRPSGHNGNGPPPSFRGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZX6</accession>
    <name>B7FZX6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_12662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180381.1">
        <property type="nucleotide sequence ID" value="XM_002180345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZX6"/>
    <dbReference type="FunCoup" id="B7FZX6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZX6"/>
    <dbReference type="PaxDb" id="2850-Phatr12662"/>
    <dbReference type="GeneID" id="7201419"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12662"/>
    <dbReference type="eggNOG" id="ENOG502S7GH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2150762_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZX6"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10554" checksum="68C42B345FE4FC20" modified="2009-02-10" version="1">MQSNSNGGNNSNSDFSKKDEFRRYLEKSGVLDALTKVLVGLYEEPDRPNNALDYMKRYLGAPSAVDIDGIKQENSELKIQIEKMKKQLAELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G072</accession>
    <name>B7G072_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELO6b_2</name>
        <name evidence="11" type="ORF">PHATRDRAFT_20508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180428.1">
        <property type="nucleotide sequence ID" value="XM_002180392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G072"/>
    <dbReference type="FunCoup" id="B7G072">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G072"/>
    <dbReference type="PaxDb" id="2850-Phatr20508"/>
    <dbReference type="GeneID" id="7201238"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20508"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_4_0_1"/>
    <dbReference type="InParanoid" id="B7G072"/>
    <dbReference type="OMA" id="EFMQNAD"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF140">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="278" mass="32523" checksum="6B6EAC154142FC41" modified="2009-02-10" version="1">MMVPSSYDEYVVMVNDLGDSILSWADPDHYRGHTEGWEFTDFSTAFSIAVAYLLFVFVGSLIMSMGVPAIDPYPLKFVYNVSQIMLCAYMTIEASLLAYRNGYTFWPCNDWDFEKPPLAKLLWLFYVSKIWDFWDTIFIVLGKKWRQLSFLHVYHHTTIFLFYWLNAHVNFDGDIFLTIVLNGFIHTVMYTYYFICMHTKVPETGKSLPIWWKSSLTSMQLVQFITMMTQAIMILYKGCAAPHSRVVTSYLVYILSLFILFAQFFVSSYLKPKKKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0K8</accession>
    <name>B7G0K8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180493.1">
        <property type="nucleotide sequence ID" value="XM_002180457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0K8"/>
    <dbReference type="STRING" id="556484.B7G0K8"/>
    <dbReference type="PaxDb" id="2850-Phatr46248"/>
    <dbReference type="GeneID" id="7201203"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46248"/>
    <dbReference type="eggNOG" id="ENOG502T3AJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_944816_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0K8"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="285" mass="31413" checksum="63CB0CAE33087AD1" modified="2009-02-10" version="1">MFVKPLLSRASSRAATLAARSSRALAPTTRLASRSLSTAVGAQLQALTTEYPHLDVVRYEHKNRVWSLQHVQYYSDALAIGLMENNLQPGDVVLSWLPEHFSEQMVLQFACAKSGLVLYTLDPMLATTDREKAKEALAKALEITKANVLVSQEAGNDVNYISLGHSVIPELRIFDFSLGIPFITPRFPHLRFPIHTGFDQDDKEGWLPLRHMVVPSGNLETFVDPAKISKDTPLAGELLIGADGVPTGVGKTLSNEQVVKNKIWPTFAKVLAKEYHEIKGVGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0M4</accession>
    <name>B7G0M4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CYCB2</name>
        <name evidence="6" type="ORF">PHATRDRAFT_8598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180501.1">
        <property type="nucleotide sequence ID" value="XM_002180465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0M4"/>
    <dbReference type="STRING" id="556484.B7G0M4"/>
    <dbReference type="PaxDb" id="2850-Phatr8598"/>
    <dbReference type="GeneID" id="7201466"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8598"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_2_0_1"/>
    <dbReference type="InParanoid" id="B7G0M4"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="64" mass="7579" checksum="6652D0D17B35B2A3" modified="2009-02-10" version="1" fragment="single">MRSILVDWLVEVHTKFRLIPETLYLCVNIIDRYLSQVETVRKRLQLVGITAMLIASKYEEIYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Y6</accession>
    <name>B7G0Y6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_46359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180944.1">
        <property type="nucleotide sequence ID" value="XM_002180908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Y6"/>
    <dbReference type="STRING" id="556484.B7G0Y6"/>
    <dbReference type="PaxDb" id="2850-Phatr46359"/>
    <dbReference type="GeneID" id="7201628"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46359"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777216_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Y6"/>
    <dbReference type="OrthoDB" id="38304at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF32">
        <property type="entry name" value="THIOREDOXIN-LIKE 2-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="357" mass="39778" checksum="CA9D294D158FB7E3" modified="2009-02-10" version="1">MTNIRVLRFRQMLLDPFVLGVCLLAFAGTTINTVHALVPSQGGELQKAAQQLQHHEYEPSGTLSFCRSSIVVTHPWASSAGFDYESRGGSQDDRRGERVVHSTSGSRPIHPDSYRNRRRELRRGLAEFLALDDDRLCVISFHASWCKSCQKFGLLYKSLAHKLGDKRDRKTQNIVERGSVRFASVEWGANTALCRSLGIKRLPTTQIYHAGTLLTSFACAPAKFQTLKDQIKYMTRTLQNSDRLAAIKANPLFPDEQAVQDKVQALLAAHTEQEFSKTLDIGAALIDATVMVAPPSSDQSDGSNTEDHGQGLSRAERMAAFAERIRSKQNRADHVATTAESVADSSHKVWWRFRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G152</accession>
    <name>B7G152_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180976.1">
        <property type="nucleotide sequence ID" value="XM_002180940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G152"/>
    <dbReference type="PaxDb" id="2850-Phatr46418"/>
    <dbReference type="GeneID" id="7201662"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46418"/>
    <dbReference type="HOGENOM" id="CLU_585909_0_0_1"/>
    <dbReference type="InParanoid" id="B7G152"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="467" mass="50199" checksum="FC014B86257BFE90" modified="2009-02-10" version="1">MSRLQTRHDPLSSTTILQVSPGVQSDLSPSPKRRKRRLPVRPTDSSDRENASLDRVSPVVPGDVVVVVVVVSGALARSVPWVILTLGSSAGATRTASFVWGKVYRGGADTASEDFETEQSHHAEEEVEDVSNEDEGSVEEEEDVGPVVEVATEASEEPETSGAEPGSSETTDVFQDASVGTEDITLVEDDSAAHVDRMEYADDEGSEETTTLDETADPETEDPEPTPAAAVEVAISPLTDETAPSVGKNDSVVTDETKAALSKLQYRQREIQGLRPEIAEHLVENQLTRPPEGIPDGWYREEASPRQRQRQQRSSSAIERQMPRLTRARIQRMVPVAAGVLVIGVGVQTGSLALVAAKVGALLASGGPSSPTATTQSWETVPPSHHTEAESEEGTMEDHKDKMATAVTDAPPSAVPTNAHTHSTGDIHPHSIRPGSRTANDTLDVTWLDKAITAVERRIKAFLRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1C4</accession>
    <name>B7G1C4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180829.1">
        <property type="nucleotide sequence ID" value="XM_002180793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1C4"/>
    <dbReference type="PaxDb" id="2850-Phatr36435"/>
    <dbReference type="GeneID" id="7201815"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36435"/>
    <dbReference type="eggNOG" id="ENOG502R28R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021055_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1C4"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF11">
        <property type="entry name" value="OS06G0360300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="27321" checksum="901B4FAFDB5C65FC" modified="2009-02-10" version="1">MSTVARLVVLYGNGGLSDVGRHAVQAALERDDVAHVQVLTEHPELLNEPNWACGCSSAHSFSAEDKKRFTVAKVNSWNADELSKYFKDATAVVSCLGNRQPFVGHWVAFEGNNAVVHAMKEEKVARAVVLSSVGVEEDWPPLEFHFAGKVLAFLFLTFARSSFRDLTKMEQIYKGSDLDYLFVRPVGIGEEVVPIGSWCVQKEKYKDSVGLNMAKLDVARFMIEEALHPTRHRTALVVGGKLEGAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1D4</accession>
    <name>B7G1D4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_36446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181013.1">
        <property type="nucleotide sequence ID" value="XM_002180977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1D4"/>
    <dbReference type="PaxDb" id="2850-Phatr36446"/>
    <dbReference type="GeneID" id="7201571"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36446"/>
    <dbReference type="HOGENOM" id="CLU_1398784_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1D4"/>
    <dbReference type="OrthoDB" id="45580at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21626" checksum="C796C8FC949CC302" modified="2009-02-10" version="1">MSEGSLTSPGVGRVQEGTVLPFQTEALAVSEAASKAVSLVQKYSELDPHEIDSPWQNPETIWDVLDQSRRDVTQAWGDLKTAMAQHDERLGRKLSAPTAVGSSDEDLRVAYMDMVTDAFADCLNDLKESEERIDVDILVDCLQSGLDLMTNDEKDLFLQEVHGEFDCGDNGDDVDELTPHETRRRQLGFHIDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1P8</accession>
    <name>B7G1P8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_3131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180893.1">
        <property type="nucleotide sequence ID" value="XM_002180857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1P8"/>
    <dbReference type="STRING" id="556484.B7G1P8"/>
    <dbReference type="PaxDb" id="2850-Phatr3131"/>
    <dbReference type="GeneID" id="7201711"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3131"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="271" mass="29808" checksum="CE6AF53005BB5D90" modified="2009-02-10" version="1" fragment="single">MIGLVGKPSAGKSTFFNAATAFARQRDDSETVLGGATMAPHPFTTIDPNNGFCLLPAPQDSCPEEDYEGDLTFGSTHGRNNHGRRLIPMLLRDVAGLVPNAYQGRGRGNKFLHDLTGADVLVHVLDASGTADSEGNTVGVEADGTPGAGASHPLHDLAWIRNELIEWLYTNIMFKWDTIQRKGRSKLSLMFSGYGQTEAVTRTVFDEVERFLEEAEHRERALDRLEQWDAGDLHRLISAFLGVRFPMALALNKYDLTSAKRNVEDILNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G222</accession>
    <name>B7G222_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 234</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002181265.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B7G222">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr13633"/>
    <dbReference type="GeneID" id="7202226"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13633"/>
    <dbReference type="eggNOG" id="KOG4831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108086_2_1_1"/>
    <dbReference type="InParanoid" id="B7G222"/>
    <dbReference type="OMA" id="LGEWYAE"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852914" description="Transmembrane protein 234" evidence="6">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14318" checksum="4CB0A45852E75B43" modified="2009-02-10" version="1" fragment="single">MLSVFEVVSLLAVSILWGCTNPLLRKGYSESSRDESLIPSSSEPSSAVASLTKFRNFHVWIPYVLNQAGSLLYYFTLANSDISLAVPICNALALVFSIVTSYSIGEQIHKPFQTIVGAAFVVIGVTLCVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2J7</accession>
    <name>B7G2J7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181392.1">
        <property type="nucleotide sequence ID" value="XM_002181356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2J7"/>
    <dbReference type="STRING" id="556484.B7G2J7"/>
    <dbReference type="PaxDb" id="2850-Phatr13590"/>
    <dbReference type="GeneID" id="7201920"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13590"/>
    <dbReference type="eggNOG" id="ENOG502RYTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480191_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2J7"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF10">
        <property type="entry name" value="GLCNAC TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="274" mass="31427" checksum="5A968E5E8F0D5463" modified="2009-02-10" version="1" fragment="single">MPPRRDDGSIFLSVATYRDENCFNTVYKAYEKAKNPEKLFIGLTQQNCHQDCKSGVLSNLSMVEVPPDDDCYQKFCDTDLGQPFCANSQLRVLNIDEPESLGPYAARYFTSKLWYGEQWYMQIDAHMTFANHWDSISVDMLNKAPSSKPILSHYPPSHLVDLDKRTDRAGARLCGPVFATSDLESQIIRLEGAGYDPQQLEYPAFAPFTAAGYFVAHSNFLREVPFDPFLPWIFMGEEIIMSTRLWTAGYDIFSPSRSVVGHMYVRRHKPKFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G315</accession>
    <name>B7G315_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181537.1">
        <property type="nucleotide sequence ID" value="XM_002181501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G315"/>
    <dbReference type="PaxDb" id="2850-Phatr47346"/>
    <dbReference type="GeneID" id="7202505"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47346"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360364_0_0_1"/>
    <dbReference type="InParanoid" id="B7G315"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="777" mass="86012" checksum="030EB74ED769FB52" modified="2009-02-10" version="1">MTSQETKYSFPQRSLRVLQTTKAAESPTRRAGNNLFLTSGTAFVMTQDSESPAAPPLGLETEPFVHKTPVSLSDDDSIWSDVKDTLILGFPIFLAMLSWVGMKTTDSALLGHVSADALAASALSDLWTMCSAVLIQGRVLGILCGAAVGAGNPKLAGVYLQVSYYVLGGVCVLVFASWYVTEYVWLAFGSDPKIAHMAGSYAKILAWSIPGQLAFAQLSQFFSAQRIMAPEVNASSFAMLANLVLGLVFVLGIPFPQWDGFGFVACPTVTSIVVYVQLFVLWFFYIYIKRLHEPCWGGWDWKAMTKERVRIFSDLYFPAALGMASDFWRVAVVGAVAAKLGEEEVAVFNTSYRIMWIVLILVNALSSAAGIKMSMRLGNMDHHGAKQAGEVGIYMSAAILSFIGFGVVWKIRWFGRIFTNDPVFLDLFEEAKWPFMVTLVLMNLSVAIERIPYAMGRTKEVFWLGFVASWGAQVPAVALLTTYWRSDLVGLYWGMASGYAVLSILYGYVTLTSDWKLYAELARSPLLAFFRPGIRCRWTLDENTFIGHTKGPEISFSQFAAPYLVYTTMVDPPSVTAETSYPGPAAPSDGRVQQVESNDSRWMNQVPSLPSVSIHPGHFFLFASLPFCVGAYRGYRRPLERMVQDILQQRTGGRVHIADIKSAEEDVRRAVASAVASRALSVASLASVGTFGLFTASIFYALRCQTLGEAMEVTRTWAHERRKALDRFMGTAGRVDESHPEVLATRGMTEEEEMAYISKMYLPDEEWEEEIIAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3L1</accession>
    <name>B7G3L1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181811.1">
        <property type="nucleotide sequence ID" value="XM_002181775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3L1"/>
    <dbReference type="PaxDb" id="2850-Phatr47502"/>
    <dbReference type="GeneID" id="7202279"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47502"/>
    <dbReference type="eggNOG" id="ENOG502S67A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510455_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3L1"/>
    <dbReference type="OrthoDB" id="44682at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="534" mass="60751" checksum="ECD70F8177D45982" modified="2009-02-10" version="1">MGDLSLSSTFTTTTTTTWWHSIRTAFGHRPFPAQPRWVTEAAANATRAAAPWGQLWQPDTAPRAVRAGRVRTVEDLDHSSRYDNKDDRTSDLDGSTNDDNNDDTNNDDNSLRLCVRNHLSIPLVWCWMDAQGRPHHFRKLYPMAHADTDTDTVTRDDHVEQTYTGHAFVLATEPSPAHSSDTIPSLDPSTILGAYRPHRRRDHTVHILEVKGWNCCRPGARSHVRHGSHRIHAFVPTDIDNDDDDNNQDDDNPLDVPRSVQLHLHIGRLDPTPLDTVRTNKYVQSTLAGWPVRFQSNWDGGDPTLRARLEQDLTHAVHCLPPHAVRTLRRTTPLWINRDFRYGPAASPVRARGLCFHPYADWLAHNQCHPAKQHGVELYDADEYRKDAALWGTGGVLLHEFCHAYHCLCVPQGYDNAEIQECYRLALEEGLYESVPVHGPQGPHARAYACTNAMEYWAELSTAFLGGVDTDTEYNKWFPFHRKQLRQHDPRAYQLLQRLWKVPCDNDNDNDTDDDRIDNESKTGDVLSSGIPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3P6</accession>
    <name>B7G3P6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181471.1">
        <property type="nucleotide sequence ID" value="XM_002181435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3P6"/>
    <dbReference type="PaxDb" id="2850-Phatr37399"/>
    <dbReference type="GeneID" id="7202297"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37399"/>
    <dbReference type="HOGENOM" id="CLU_1664128_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3P6"/>
    <dbReference type="OrthoDB" id="48976at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="39802" checksum="4A4AE6C3959CC3F7" modified="2009-02-10" version="1">MSSEDEDVLHKYRKYDPPPQELPVYSSDEDSSGSSILTANAEPLTAKADLLKVLDYIIIVGNRNRYQSLQATREQISETTTGSNELSEIEQTDDFELSGMHADDFQLDPQRRKKSRLSAALLCPSYAAWEETNRTDALDCTWCHQYSDCIALPYNKVRSKEPPALKGFFYTRTDRDLTLRCWRKAVHAASTVMVLEGVNGNVRLDLTSANSAEKDAKETCLNLGIALSNLKPYTCPSCFKVFQSCRARECHFWGENNHRGCCWSLVHKKRHSILKEATNKESTICQHVLMRLILCSIHQKCHQLPKILDRKFIVCLLGAARLHHLRLRQTSSKLSQYPGSASLDEHSPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3R4</accession>
    <name>B7G3R4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181480.1">
        <property type="nucleotide sequence ID" value="XM_002181444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3R4"/>
    <dbReference type="STRING" id="556484.B7G3R4"/>
    <dbReference type="PaxDb" id="2850-Phatr37417"/>
    <dbReference type="GeneID" id="7202306"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37417"/>
    <dbReference type="eggNOG" id="ENOG502T8ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734591_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3R4"/>
    <dbReference type="OMA" id="MDEHTAS"/>
    <dbReference type="OrthoDB" id="439612at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021325">
        <property type="entry name" value="CCB2/CCB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044705">
        <property type="entry name" value="CCB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34943">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34943:SF2">
        <property type="entry name" value="PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11152">
        <property type="entry name" value="CCB2_CCB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855698" evidence="1">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="40056" checksum="25EEB87C51310A6B" modified="2009-02-10" version="1">MKRTRLAIYAAVTLQTSTTLTLALMPSAAFSCSRTRDYRLRSTVKPPLHQFGKLTRPPKAPKSQSHILSTNKCLVSLRSSNSDDELLSTTTTSKAKVRFSTSKVSSPGEASNSNLLDSILSWITSDVGSVILGFSGLIALLVGRLLLSSLSSDDTIASSPDAQSEETRANLLAVFATGAVLLNGISKLDVESALAPLVELSGQKLSEPVYVGVDESQSTAAQIGWTLKALLAATPAQSAVLLATTLHPFSNSNVKSPSSVGWQVVALAGIVPSVSPSLPTGTAILDRFRNSATESTDETYLPTLQALPGRTEFTYLPPNTQAVLLVPVRLQQQSIDGRDTVTYALVLGGNRARVFTPKDISWCQSVAQRLGRDLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3U7</accession>
    <name>B7G3U7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease P</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHATRDRAFT_47281</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181672.1">
        <property type="nucleotide sequence ID" value="XM_002181636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3U7"/>
    <dbReference type="PaxDb" id="2850-Phatr47281"/>
    <dbReference type="GeneID" id="7202366"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47281"/>
    <dbReference type="eggNOG" id="ENOG502T6JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435806_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3U7"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852976" description="ribonuclease P" evidence="14">
        <location>
            <begin position="27"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="PRORP" evidence="15">
        <location>
            <begin position="458"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="690" mass="78645" checksum="9F09E96C5A5EE38E" modified="2009-02-10" version="1">MGKGKRPSISLFAFLQATFSVVSIQAFQMPTTCRTMSTVVSYRETYPQHPCFSQQRYNSHICMEPGIIQVEELSDQDTFCSYINCMKEIVENQRVVKKCSLDECKPVQEYLFSSQSLLSLPDISVDGFKDRLRDQKRQFLEETGFSEEQYEYLVRCLAYLGDRCAKIQQIAPALIAWKKMRESGMKPRERFVSTYMYVLSLDERNVQACFETATFHDVLFEPTEKSIFLRIKTLISQSDAKTAEYILSSLPDRQGKSSEWKKLRTFLPILSHYCDVGDMISALNLFRKMRKSEGVIFDSETYGLLIGALARRGYFIPGGLSVDGASTLGSLEMGGPALFDTISTEMAEDLLELSLDAAETILDGFVSGFAGENSYEFDCVTDKCINVSPLLTIGRVTVNETSAVCPATGANLRLFALTEEQRISVHDTLLEMAAVQHEDFSEKLKARNQNFKGRGDSERARRNLFEFSEWLREHEGEPFTAIVDGANVAYAGHGNVHYSQVQLVVDKLEDMGEKVLVVMPSKYVGEKFYVAGIDSVQQLSEREVGIMNGLLDEGKMYQVPAACLDDYYWMLASVANQTEHQLHVSIDNRQRRFPGLRPMLVTNDQMRDHKLALLEKRLFRRWTSCHIVNYDLESYSENEWQDRDVRFVPTDFFSREIQGNEVGGERSSTVWHYPVTGWEGSDRLCINIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4E9</accession>
    <name>B7G4E9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_14163</name>
        <name evidence="1" type="ORF">PHATRDRAFT_14251</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181902.1">
        <property type="nucleotide sequence ID" value="XM_002181866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181904.1">
        <property type="nucleotide sequence ID" value="XM_002181868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4E9"/>
    <dbReference type="PaxDb" id="2850-Phatr14163"/>
    <dbReference type="GeneID" id="7202686"/>
    <dbReference type="GeneID" id="7202847"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14163"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14251"/>
    <dbReference type="eggNOG" id="ENOG502TB2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2101869_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4E9"/>
    <dbReference type="OrthoDB" id="2101583at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34966:SF1">
        <property type="entry name" value="OS04G0508100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34966">
        <property type="entry name" value="OSJNBA0043L24.15 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="56" mass="6535" checksum="C8FD059064BBE988" modified="2009-02-10" version="1" fragment="single">MSQFIQRVANYIANEVLIKGLANSKTFQRFAIRTDHNLQNLHKTGTEHFEKAFEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4G2</accession>
    <name>B7G4G2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_14301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181909.1">
        <property type="nucleotide sequence ID" value="XM_002181873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4G2"/>
    <dbReference type="STRING" id="556484.B7G4G2"/>
    <dbReference type="PaxDb" id="2850-Phatr14301"/>
    <dbReference type="GeneID" id="7202863"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14301"/>
    <dbReference type="eggNOG" id="KOG4494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047493_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4G2"/>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
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        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37529" checksum="58548763C4DB2902" modified="2009-02-10" version="1">MRFNFAAVTDLDELSRVEWEKKPTFRSVLVPGTLTATQGRYHIKFENARELLTLHNEAGRGAEFSELTVYNDRLLTFDDRTGDVFELLNNAEATKSFVVPRFVITEGNGDTDKGMKWEWSTVKNGELYMGSMGKEYTRPDGTIQNRNNLWIGILNAEGELRREDWTDQYNVVRKALKALSPGYLIIEAVNWSDHLQKWVFLPRRISETAYDENEDERRGGRQLVLVSPDFSSTQVVDINLQKDPLKGFSTFAFVPNTNDRHAFAIRSVEEDCVGGLETCKQRSYFIVFDVLSGETLSEEVKYPEDLKFEGLEFVNIYTKPPPFSNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4T7</accession>
    <name>B7G4T7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002182130.1">
        <property type="nucleotide sequence ID" value="XM_002182094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4T7"/>
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    <dbReference type="GeneID" id="7202925"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47763"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="InParanoid" id="B7G4T7"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
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            <begin position="129"/>
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        </location>
    </feature>
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        <location>
            <begin position="167"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34758" checksum="6366F1B3ABF4E12B" modified="2009-02-10" version="1">MSDSPSLYLLSDTIDALTTPGTPVFCTGVIWCIVTVGTWLVSTLTGNYSQVDKLWSILPAVYACIVVCDARTTLMAAVTTFWSLRLTYNFYRRGGYAWPPWRGDEDYRWSYVAQGKMVSILANPVVWHFFNLAFISIFQNVLLLLIAAPSIVAHVHAVSVDFTSGNALTSVDFIAAFSAMTFICIEAIADNQQNTFQTEKYRRKNAGEALEGEYLQGFLQSGLFAIVRKPNYAAEQCLWTSYSLFAFSCTGVMIHWSYIGCILLALLFQGSGRLTERITREKYSAYAGYQQRVPLYVPSWTILSNGKGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4U0</accession>
    <name>B7G4U0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181973.1">
        <property type="nucleotide sequence ID" value="XM_002181937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4U0"/>
    <dbReference type="PaxDb" id="2850-Phatr38057"/>
    <dbReference type="GeneID" id="7202744"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38057"/>
    <dbReference type="HOGENOM" id="CLU_664752_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4U0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852915" evidence="2">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="410" mass="45393" checksum="1F0D0A40425F0651" modified="2009-02-10" version="1">MKLFLSVATTALLAGGARAVNLRAATPREAAVEGTQSSFASQAASQLAKKNKRKKGKKYSPSSDSDDPIMHGHLQIGHVLDVSSADAKADIDLIESAFVNAYNNANPNGKYEVTSMTLEREVVIPEDLEATLTSIKGENVGQLRPGVFIDWYYFFGFHCRLCRDDDDYAALSATELPVLEASAHRVFEDQFCLTLHQSGLEEYSALADCSILFDYDGDGNDIDSGDQLELQKKNKRKNKKKGKKKHANDDKAMDGRLLIGHVLDLSDVDSQAEIELIQTAFVDSYNGANPDGKYELTSMILERERIIPEDLEGALATIKGENVGQLRPGVYIDWYYFFGFHCRLCRDDDDYAALSATELPTLSVSAHRIFEEKFCVSLKDSGLNEYSEVSECSIIFGGDGTYENIIEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G550</accession>
    <name>B7G550_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182353.1">
        <property type="nucleotide sequence ID" value="XM_002182317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G550"/>
    <dbReference type="PaxDb" id="2850-Phatr47852"/>
    <dbReference type="GeneID" id="7202984"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47852"/>
    <dbReference type="HOGENOM" id="CLU_779562_0_0_1"/>
    <dbReference type="InParanoid" id="B7G550"/>
    <dbReference type="OrthoDB" id="47850at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="359" mass="38550" checksum="F244BCBD3B2C029C" modified="2009-02-10" version="1">MLRMVKIQNRSSLVRTRTRSYGSWLTAAAAFSATTGSATVNAFVVGTNGSQRPLQTGRIVPTTPVPVLPKKSWQQPTSLRLYGSQRDSSRVDDILNKVKKTAKSAGSKVKDVADRSRVDGILNKVKSKAKSAGSTVKDVANRSGVDDILNKVKRKAKSAGSKVKDVAKSVLPSSWFQSAKEKEAAMENKRIEKQVRGSLKEIFKDAPLPIRMLGGIVGPIMSSVMSKLSKTIADQQEVVEALLDEARSYITGNEEVENVLGQPVTVGSAFSQSSSSTSINGQTSSHVELGFPVSGPRGSVMGRLIAINGKIQKLEIQAAGQVIQVALRRPSQFFSGGTKRSSDSGKIIEAEIIEKEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5T1</accession>
    <name>B7G5T1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182462.1">
        <property type="nucleotide sequence ID" value="XM_002182426.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48047"/>
    <dbReference type="GeneID" id="7203405"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48047"/>
    <dbReference type="eggNOG" id="ENOG502QU3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230506_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5T1"/>
    <dbReference type="OrthoDB" id="39934at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1747"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2010"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2101"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2140"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2252" mass="253925" checksum="F6B9464B886D6FC3" modified="2009-02-10" version="1">MLRLACRMSGTPDQPHDPADVAIRQGEMNMASLLNPMPPMAMDDEQPLRHTPMEDSDQSRSSAAIFVSRVSQPLVTLPPSSRHLARTTGSSTRHEGGENPVWLAQPPSVSSISHRNICDFGNKGFDSDRGWYLRESCLLSMEVGSQRQVVSTPCRRDCNGQIMPVAVQSPLISRDESFFRDRKKALQAAMSERSKYDIQLNNEVGALGGAWRGIVRRFMLWAFDNVNALQLSRALQLQLPFQTGYESYLTSQVIEALDRGDPSEVADVLSAAFLNRNVSRVMVQNLGPRYDLLWHWSTAITWNRAFDAWGQFPLVGITGFPATENFPSTRNHALASIFRVLLGQGNWITRVVTQGREGILTDNPNNKAQNLAPESNGFELANRNQYGTYFGRVKTNEFRYAHRLPTDESIVRTFVASPMATMSNNGVVHVLRMLDKHWHNMLSQEWGNFAHQRMEQLDPFETLRFHMPLVLVTLSNLRGRNAWDAEVLGPAVRKLQALKPGLDTAAAWKLAKELEDDVAVTVSGGVASVFVPLRSWLKAIRESLDRLERKAGEVLKIVSSVEMGIRLGHDLVTQVSWKVPSDSVLKAAILNHIRGKDKQAVIANDQDAADAPDANAVDSWRIRSALQKTTPRDMRTLIELVKGNLEHMKAAQLLIGRVKTLLQRELRRGYLNQAIRDLSKGPYINGPLMRDEWYWLEEEHGQGLHIYIGKIPDSGLHQFIHVDSGNDKTISLSNGKVLARAYIPVSESISRAQKAFMTIELEYGKTFKYSAFMEFSMLRIALQRLVVVSQMNCEELDNARLNVLREIQRSKQTVLGPEDLTPGNTYYTFDESKRQYIPFLCETTNSVSTQSKRAKYVRAPPQSVLVVGGGPTGLLTTIHCAEACLATGGVMKLQEARDAFAKGGSTFERAQVVRLDARWISMLRYHLGTIFEDVYIPASGETDAQLGNTLPTQGFVEITIKDLESSLHTEASRLWSRGIIFVHTDSKARYDATSNSMIKQGKNLKDGDVVLRPVDSHGKDSSHFHSWKVSEVRYTKVLGIEDLKVGEEYGVWIHQEQKVLPYTLVAVDLDTELYTFRSHSKDKTSIYPPGTTTKAHAGVREVVFEGLGNRQEGGLPKQTVPFDPIENVNFTLDLGNTHVVEAIGKQYPSDVHIGVTTKEPYGVCCMQGLKVSMGMHNFGEKRWGTGILDDIRSQNDQNTRIIGDFTKMVRVVPIVEHMYQTISKDKDWRMHFSNVIKESGFPEVAELQPVFSNLVEGCRLLSQASLNFRRKTLQTRFFETGDNYYLGMEFPREYDAWKNALSFSLVKKLSATGINSRAVERLRSSLMHHIDRLWYNGCLETIRTGDVYNPGARERVPRLYLINSYMEMSLSALPIGESFRLVSEPQSKYEVLAISSSTILVRNVEGYLSKFKKSTKVLREGNLTRGPDGNQESKVALATFDVGHYVNHRTMRLLNKDQGYVFAFIGDEQATPHFMRYSGLTGACINAMSFNNFITDAGRGVSFEERLQQYSEETDWSNGEVVQRGTGANYGDDGFLRPEFSYRDGVAFLYSKIVEFGEMGKDVNNLLTRDWMVKLTASLVPRGMELNQVFLEGLQRHWKAAVFDKLMASVKSDTPVDEKGANVVDALRSSSSTLVEKNAASPVYWDELTTSLQLDTATKDVLSTRHFPVAKRLCEIINELIDFASKAYLYNERISSELSNQPKSVDSLIDDFSVEAQNFANSLTQSAAFAAGVLAFRLVGSNVANTFSAVFAGLNILIAFGTMTNVSRYKIRNEEWRVFFADQKFSGVKCAVFALLSKDDQDSTPLEQHPFIDILEKRVKSFRETVGYYGYSNPTEFDEAYQQLKSRANNSSELQNFRDLLVTDLLVDTYHVNSYVQEKLVDVFRVLDEMIFLLDSRKSKSASKAKQLFDQLLAYDSVLEDSLQRGPVRFGFIKQRKFLHWNLIAAVRYLSRVFCCFSRPRQSDRALFQIETLGIVRSLQSLSKEQDSKVLRRESRDFETLLWATRESEIASLIFLSGFFVFFASVLFSVARIFNIESLENAAFWANAISSFGAVLAAFHLIRKFSILFGLWATLWVKTSNTVGMDHINIRRIRDVTSIQALLTLTRLVAAVGAAVALPWSVIENAFPSVITLDEDYPFWLASGAVCAAILATVFFFVVEYVVRYNLSPQLGPFVSELFRDEIEAMFNDLAQRQNDIDTKVVQDRENWEYVAREFLHKYRFDTVFAADRFGTIFQYIQAGMEGSGDSKIEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5W1</accession>
    <name>B7G5W1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_14769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182474.1">
        <property type="nucleotide sequence ID" value="XM_002182438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5W1"/>
    <dbReference type="STRING" id="556484.B7G5W1"/>
    <dbReference type="PaxDb" id="2850-Phatr14769"/>
    <dbReference type="GeneID" id="7203423"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14769"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761782_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5W1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="160" mass="17962" checksum="9DCA21AC2256F5BD" modified="2009-02-10" version="1" fragment="single">QVATFALGCFWGGELAYMREPGVVGTGVGYTQGQIEQPTYEQVCSGTTGHTEAIVVTYDPALVTYERLGQLAMERLGENRYLRNQVGNDKGTQYRHGIYYHTQEQKKIAEGIISSYGEDCQTECLPAQKFHFAEDYHQQYLLKGGQSARKRDSSVIRCYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Z7</accession>
    <name>B7G5Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_38475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182635.1">
        <property type="nucleotide sequence ID" value="XM_002182599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr38475"/>
    <dbReference type="GeneID" id="7203464"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38475"/>
    <dbReference type="eggNOG" id="ENOG502STW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1351201_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5Z7"/>
    <dbReference type="OrthoDB" id="49216at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF47">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852949" description="N-acetyltransferase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="203" mass="22462" checksum="7D06AED5BCD167F1" modified="2009-02-10" version="1">MIRPLVFLFVGWVTEGFCLSSPSVLVKVRQVQTESDVTALADLRYNEWIANLGPDAPSVEAFRGATAELQAERAAGGAFSFIAWQDPHQVVLGAAELSPLEIDGALKIPADKMLYVTDVVTARQYRRNGVAAALMMAMEDEARIQQTSYLLLHVEEGNEAALCFYRTRMGYIDPTSDLLSRIDTELLHKNTNTWGQTVLAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G628</accession>
    <name>B7G628_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182504.1">
        <property type="nucleotide sequence ID" value="XM_002182468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G628"/>
    <dbReference type="PaxDb" id="2850-Phatr48128"/>
    <dbReference type="GeneID" id="7203282"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48128"/>
    <dbReference type="HOGENOM" id="CLU_677010_0_0_1"/>
    <dbReference type="InParanoid" id="B7G628"/>
    <dbReference type="OrthoDB" id="45868at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="407" mass="46089" checksum="99DEE2C351E3B0CC" modified="2009-02-10" version="1">MVELSTRSSTNLEMDLKALVDRLGAERGQSASFDRWRKQFLELHESFLSQQGIEEASDAYKKLCTYGEKFATTLIHVQRLVDEDIFLNKGESHVSVKGQNALHQLNTIMTEVVQNLHDMVPSNTTEERTCGYNKYQLGAALVEDNFSAYSYLLHCCQISTRMRQSCLEDVADKQILEMIEYYELNLKRFCDLMADLGLYRWMVVQAAEAGKPLASPPKSRRKANIPRRTNNTAIERSSSPTKSRIKSPPSSPLVKVQSPTSPPEKSKIIDAVKTKKIPKVPISPRKTKKETIPTQSNGKKVRNGNSKPKATRSLQSQDSEPIKPDKEKEEEEKAKEREEYYDMDRDDMTPEERRRGGKGPAEFVVFVDIKTGAVGNRGNEIIVEATKGEPERKELMNMALQSATKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6D0</accession>
    <name>B7G6D0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metacaspase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_54872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182552.1">
        <property type="nucleotide sequence ID" value="XM_002182516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6D0"/>
    <dbReference type="STRING" id="556484.B7G6D0"/>
    <dbReference type="PaxDb" id="2850-Phatr54872"/>
    <dbReference type="GeneID" id="7203526"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54872"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058143_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6D0"/>
    <dbReference type="OMA" id="CADHQTS"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="322" mass="34783" checksum="3EC1A4A75269D9B8" modified="2009-02-10" version="1">MSNYLERAEELIPAEVRMISGCRDEQTSADVSNVASFSLPDPAGSAGGACTSAMLKVLYANHKAPQKDLSFQEVLMKMRGILSQGRYTQIPQLSSSRPLDIHQSFNIVPANFTGTRRAVMIGINYTGQQGQLSGCHNDVKNMIEFIKDIHGFEDENITILMDDGAHTEPTYKNILAAYHELVSSAKAGDAIFCHYSGHGGKVRDDDGDEADGYDETLVPVDFNAAGQIRDDDIFSALIGPMPAGVTLTSVMDCCHSGTVLDLPYVFKADGEQNQMAPPPDFDFSKLAAMFQAYMVQQGANGQGGIDPNDAIAIVAKECCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6P2</accession>
    <name>B7G6P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182891.1">
        <property type="nucleotide sequence ID" value="XM_002182855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6P2"/>
    <dbReference type="PaxDb" id="2850-Phatr48305"/>
    <dbReference type="GeneID" id="7203733"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48305"/>
    <dbReference type="eggNOG" id="ENOG502SVI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766099_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6P2"/>
    <dbReference type="OMA" id="HNRMEND"/>
    <dbReference type="OrthoDB" id="48069at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40621" checksum="38B93104E2315B1C" modified="2009-02-10" version="1">MLRRSVAGGGGSLGLPTTSANQDSKPFFRRDNHKKPDGSAASIHLTNPLVKQWKDSDTATKISYGLLLTFLLMIYSGYRTLRYNNASLWMTCHAQDCVLQISPRGWEKTTTLTFARSQLVDAETVKTSNDGVYLGSNPDLNEERRQAHNTGKNKKNTHKNKGSVGSYRGPDPEGNYITYAVVLRDDSEEARQHQAESEDGQGQAVVRLTSVKPFLDVAQDGSFRLIFRQFGITQTRRRVRTMVSKIESYIKHRRQKLVVKENASPSAFAIILMVGGLVGALLTVLIGSFWSDDESYRKQRLGQRRFAQQQKQQQLHSSPRSSLADVIAARTMPSRYEVQTAPRRTTLSTSGNKTTTTTRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Y1</accession>
    <name>B7G6Y1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lhcf8</name>
        <name evidence="19" type="ORF">PHATRDRAFT_22395</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182937.1">
        <property type="nucleotide sequence ID" value="XM_002182901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Y1"/>
    <dbReference type="STRING" id="556484.B7G6Y1"/>
    <dbReference type="PaxDb" id="2850-Phatr22395"/>
    <dbReference type="GeneID" id="7203582"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22395"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_4_1_1"/>
    <dbReference type="InParanoid" id="B7G6Y1"/>
    <dbReference type="OMA" id="CIAHNAD"/>
    <dbReference type="OrthoDB" id="39049at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000011">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855499" evidence="18">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC45673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="200" mass="21651" checksum="1FA304834032593C" modified="2009-02-10" version="1">MMKLAVFASVLASAAAFAPTQSSSRVSVATNMAFRDELGAQPPLGFFDPLGLVKDGDQATFDRLRYVEIKHGRIAMLAVAGYLTTEAGYRLPGNIDYSGLKFADVPGGFKALDTINDAGVLQIVAFIGFLELAFMKEVEGKSEFVGDFRNGFIDFGWDSFDDATKMKKRAIELNQGRAAQMGILALMVHEKLGVSILPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G739</accession>
    <name>B7G739_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_29561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182837.1">
        <property type="nucleotide sequence ID" value="XM_002182801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G739"/>
    <dbReference type="STRING" id="556484.B7G739"/>
    <dbReference type="PaxDb" id="2850-Phatr29561"/>
    <dbReference type="GeneID" id="7203675"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_29561"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="B7G739"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="319" mass="35816" checksum="908FB02D9D0D3EA0" modified="2009-02-10" version="1">MPLDVDECLETLKSGECVSENSLKLLCQGVSELLTEESNVQPVLSPVTIVGDLHGQVFDLLNLLKVGGWPPDTRYIFLGDFVDRGHNSVETLSLLLALKLKYPGHITLLRGNHESRQVTQVYGFYDECLRKYGNASPWRHCVTCFDTFGIAALIDEQVLCVHGGLSPDVRTLDQVRAIDRNQEIPHEGAFCDLVWSDPEDISVAWQMSPRGAGYLFGKRVTDEFHEVNGLQLIARAHQLVMEGRKYHFDDRLVTVWSAPNYCYRCGNVAAILEIGGKPGNDTEGFEGSIPQRFQFFRETEVSMHGPKGEERAQLVPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7H1</accession>
    <name>B7G7H1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183014.1">
        <property type="nucleotide sequence ID" value="XM_002182978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7H1"/>
    <dbReference type="STRING" id="556484.B7G7H1"/>
    <dbReference type="PaxDb" id="2850-Phatr38979"/>
    <dbReference type="GeneID" id="7194694"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38979"/>
    <dbReference type="HOGENOM" id="CLU_000850_0_1_1"/>
    <dbReference type="InParanoid" id="B7G7H1"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="733"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128685" checksum="EF104D9B1B6A15BF" modified="2009-02-10" version="1">MDPLEHVLVNLLGATTPDSSYRRFFEEYGITQASELASITENRLATVSYGVLTPSVGDTPATIVRMFLPPAQQDRILKIVKWFLSKGTDVTNETWFELTPEVLEYWQPASAIVAPATPVGSDARSSFVESAAAKFRKTIKNHSVPYPKFSEDRFWVTWNTNIRIKLRIHGVQLVLDPDYLPETVDETDTFVEMQNFVFGVFNDILLTPRARGILHKHVDELDAQAVYRDLVASYGKGINAQITATSIETKLTLYSFATSKSKTCVAFLTTWRNFIYDLERINEFPLPDHQKSVRLKSAVRSHPQLKLFLGNVQLYSRTHVGKSADDSDFEYVYDLMLKHATDIDQTDLEDRGNNRGGRSANNAKSQSSSKSSSKKKTNKLIGKKHKNYVPPEKWNALSPEEKRTIMDQRGPRPAPAPAPALSVNAAATQPPPTLASTHVPPAAGPGQLLRSLISNSAARQHPAPSNGATSDSFSVNGTTYRREVNRASVQYRLSTHDVSLNKDSLIDGGANGGLSGSDVTVISQSLLEATVSGIGNSELTNLRLSMVAGLIHTTDGPIIGVFHQYAHLGTGNTIHSCNQMRSWGVTVDDVPRTFGGKQRIVTSDGRFVISLSVSGGLTYLSMQAPTEEDLDTFEWVPFTADNEWDPNGVSSPAAADDDLSLQLPAGHVPFRDERINNFGLLAHSAAVSRSPLNADALQPNFGWVPSACISRTFENTTQFARADARLPLRKHFKSRFPAANVSRLNEIVATDTFFSDTPAADDGIFNHGGATMAQLFVGKSSQITSVFPMKRESQFAHTFEDFICTHGAPDALLSDNARAQIGQQALEILRMYAIDDMQCEPHHQHQNYAERRIQEVKKMVNTIMDCTNTPPEYWLLCLFYVTYLLNRLAVESLNWRTPLQVAHGQRPDISALLLFRWFETVYYYNPDHASFPSASREKTGRWIGVAEHKGDALTYWILTDNTHQAIAGSVVRSANVDNGLKNHRAANSSPDGGEPSNPKPIVLATSDLRHDATVDPSFEKSPAFSPDELIGRYLIREAPDGQSHRALVARKIIDADSDNHQTICFLLQIDEKDADEIISYNELSDLMEAQQSEPATNGNIEDHFKFTSIIGHQGPLQPTDAGYKGSSWNSHSRCTRLTTISLTCPGGAASIVCFATVMTSIDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7L1</accession>
    <name>B7G7L1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183037.1">
        <property type="nucleotide sequence ID" value="XM_002183001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7L1"/>
    <dbReference type="STRING" id="556484.B7G7L1"/>
    <dbReference type="PaxDb" id="2850-Phatr48534"/>
    <dbReference type="GeneID" id="7194711"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48534"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232520_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7L1"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-T C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114932" checksum="CA4CEB8C3774C20E" modified="2009-02-10" version="1">MSSGYQWSGVSAAQVEEWVQQSNNPADSAQQWQATRNLQEWTASNVNVPAILLQLLTTSCGSNARPNTSTHREAVQFYALTTLGRLPLAPEERRHMRTFLLSQFSFLAANGSDSRSSTNTPSSPSAFLRNKAAMLLTQQILTDVPTGNWNTVEPDLLRLAGTDPLLFLKTVETLLEDFQTNETDKDSIRQVKDFLKGHLTPHDTNPTFLESLFSTVAQILSQSLSTNPSESKHAVILLAIQTVKGFFQWTELIFLGKESANRVLEQLLVCLQPQQPEEIQWTALQAWQEWITSDSVVSKERESSIQTATDPKLPVLTALLEKIHEYNLLPYTGESAYEIEVVIEVGKVVNTMGLEITHLWQQTASNGNADDSSVHTLFHQILDLFFRAFAYDDIDVSLAVLPLASKLAAVMSDEPAHDAKDSCNQLLRRHLPQTLNILYQQIKYPKDFSFNFIDDENAEEEQYREELGKLYVKLVRVAPTTCFQFVCEAAAQWLDRTNSSNTNDGCITMSNAPTPDLEATLRLLYKYCEGIRPTPGMKTAMKNQTFCALLVALHESPIANHGHFEILCWYYDVAVRYYPIFQHSNHTILLSRVLDAMTGARGLQHGHARVRSRCCYLLLRLVKAIAPLLRPFVETAVAGIQGLLTNTTLELRPDDTLYLFETIGLLLGKTGIDAPEQARYLTLVMTPHVRSIEKSLQDPRLLQDTEFFGDRLAQSIAALAHLSKGFSKPAQSIQLVLMETVNITQIIMEALPNHEQVRNKTMVLLPRMIQCLGDQVLDKIPRFLYILIEHCNSEDVLFVSQIFNQLCIKFKEASVPVIDGALMPFLRKCYALVPATDDVAGTSDVPPHLRTEQLSIQKLTFVVLQHIVTHNASAVLMSPTNVGNLESVLRSMSDGAVYVTDPIVQKTCVKFFREWLEQLTNQNTELNRYRRGFLVFCGQTFLPGMLHVLLSPSFDHRDAMQARVVAELAGALYGWASQVSDNDALELTSRIPALADNSNVAVALRAVGSAKDAETWLTQIFQSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Q8</accession>
    <name>B7G7Q8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183189.1">
        <property type="nucleotide sequence ID" value="XM_002183153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Q8"/>
    <dbReference type="PaxDb" id="2850-Phatr48574"/>
    <dbReference type="GeneID" id="7194797"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48574"/>
    <dbReference type="eggNOG" id="ENOG502RWHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290620_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7Q8"/>
    <dbReference type="OMA" id="AWERTIY"/>
    <dbReference type="OrthoDB" id="49686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119219" checksum="8EA6A2231659834C" modified="2009-02-10" version="1">MFLQPPGKKPGGVFHSRLGSRPSHISKLSSGLGLGMRKKKLDHSNGGHTQLMARASLAPIEQQQQSHELAQMNALKITQEELQRDLETLGLQQQESQRLLDNAKNFKERRVHQHAELESKLEHIKYKVGQERAELQRRHHLLSSGQRALSLARLSGDRTGDDLRALDRKLKQVLETKRTLFFYQRKQDRLLHDLRADLSSLAHEKTEATAQVHAADQNLKKLKLTEHSLRQRIQSESKKLAAFSQQTTLLRAETMSMEHMIDEVTDALELSEAAHAKCAAETVSEEDRHNKAVIALEAKIEGKYSVHRKLSQEMQVLRQTALDHQSDLHLAWERTIYAQIANGMTPSKSQKESNIPPVLEFGCVEVKVETETKACEEEAQIIEDLKATLSSFKDQLDEMEERANTSSEKVELEQGAINNARKTEESRRDEASKFLIDIVTLRRENEHVRASFDTLRSLRDDQNAGIKRSIDTVRQENGQAEHNRSLAQHRLSKVATEVRSTSASALREKEAIALKLAEFESEISTVHQCNLSAKEELNRLSSIIESQDKLSRNSLGLSQSAAKKNIAEILNEYPDLESVRFGYDPKKTLDEQADESLKLIVAHCKHRLNSAKKMQAGLREAAKLEDLELREMQKAAAIESKRKFKIREYRKHRLLSGTSGNAIKQSNLKDEKKHKSRRSLQSMRVKASAWIGDEKTEKTRRDKKKMRREELQHQTEIALENSELNSVAKPRDLLEVFSRVGDDGGKSTYDLEACAVLTQTTAGSEKKVTWEEDNGKEKRTSKISKKDCTRGRKTKECLSKDSTEKPHIPKLAPSSLSATMLDAGFQEVSALLVEKEASSHRISSSKPVVQKSYTLPSVDRISREPRSQDLKKLLSCKSIGHTGEKTRSNSSRFGNPKKRDIDVTTNPRREMPHSFGSTKPISKTRGENAQSLKEWSGSSTSHRAFEDKTNSSKTKDQERRTTSHQREKGKRSHRSSADVRTASTDHKKMNYHLSLSHNSNPSLKRNSCQTSGLSSKERPAKSRRRLKSRSSDVLKNQIQTFGDERYSFGFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G848</accession>
    <name>B7G848_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002183376.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr39253"/>
    <dbReference type="GeneID" id="7195189"/>
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    <dbReference type="HOGENOM" id="CLU_246778_0_0_1"/>
    <dbReference type="InParanoid" id="B7G848"/>
    <dbReference type="OrthoDB" id="49473at2759"/>
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        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="term" value="P:cell adhesion mediated by integrin"/>
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        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
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        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="FG-GAP" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="399"/>
            <end position="411"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="497"/>
            <end position="516"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1538" mass="161049" checksum="E6214D152A322FA6" modified="2009-02-10" version="1">MEDVEEVAEALPTIPEDVPTLTTEEATTLPVPVANSDLDEVTDAPESVETEQSPEIVEEDIDTSEPASVTNSTMDDYDSVASEQSNNVSRDEADSHDSHEEVQGLTVASAVGPVSSPSHVSGQFDEIEVDESMLLPTDDEEELIEEETEQVDFREDSSGGFEEVEVPSDNEGDILIADDEPLEDDDTHASIDQVSESDDSAHSGEISPEDEVPNGDTSDESIYSVSDAPREESVPSLDSAVSLSTEDRSSNSVSFMLANNEVFSPSDSAVVNPNLSMEPLTKTASVAHTEPLEFELDEMGPVTGIQIEDSSSRTSVNSSSHSDPFSRQTDDSNEVALIPFVDSNESNASQWTPLSASTPVMTPSGRVFAPAPPTIRNSTMGLYEDEPTDEMGGMDRHNENPTVVPKHEDLNRNSGDTAKIGKVTAAGTVATALAASERSPLDASMPMEDAMSTHPIETSGSYHEAGLEDKSSSHNLGEEFHDESASGDDSVFSGAEEGSDGDMEGVAIEETDDEEPDGVREESLEELDREEFEFDSDDGDDARVKGQSSLVLTAYAGPESDEDSVSLVRTSDDGEDIEIGLEGASEKDSASYRDEYGKSMDEEDSHYRGCCAVFLSNPCTQLLCCVISVLIILGVILVVVLAGGDSPTDGGRPFPTGAPNGGSVTSAPTPDGFTRMPTTLPTNSPTPFNIESVLLAKLSGIAGSSFGFSAAMTRSSRSFMAIGAPEGGAGSVSMYSNSTGQWQSFQVLSSPQQEGRFGAAVSLTDDTSSTGLMVGAPNVLATGTNIPVGAAYYYEYNRADARWAQLGSVIQGGALAENAQEHFGAAVATSDVYRVAIGAPMNNAAAARAGRVYTYEYRQDGAIFDWVPMSDSSVTGTTTDERFGSSLDMSTDGNVMVVGSPFRSLFYIYQWNGSTWSFIFSGSTPGGNLDEEFGSSVAVLSNDFIAAGGPGASNEAGVVRVYELQNNGLFRQFGPDIVGRNGERIGELNSLTGAITERGPAVSVGTVDGLIRRFDYNANLGEWQERFEAVSTGFSGPVSSLSMVTNGLASSIVAGHAAGNEAAVYEAFFGLTANPAGVPDVTLPPVASDSPSPTAVPTPPPGPETMTPSPTAVPIPQPSAESLVPSPGVSSSAPSLLLTLSSAPSPATVNMTVLPTLAPLSGTPSSAPSVALLAISLVRLLPGGSPNTDTGSSVALTDSSLAFGAPLFQNGGGIVQPYRGSGGGYTALDPIFAVNGGRFGEAVDATDGGGRNALLVGAPTAFDEQGLNVRFGAAYYYELVGDVYSMIGSTIEPPLTPQASGGRFGTSVAVARNIRRVAIGAPFTSTSATVQRTGRVYTYDYDGTNWTALETTPVEGFVTDDFLGFDVDLSDDGSRLLVGAPGSTSGVVLYYQLSGLFWQPIFSLPGFESDELFGTTVKILTADGNTIAMGGPGFGASNNGVIRVYRRSSDGTFVQQGQDIVGAANERLGNRNTLTGSNGKLLVGTASGTVKRLDYMVSTDEWTQVSEQENVSRISALDTTGSVDTFLLGDFLIEACPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G855</accession>
    <name>B7G855_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_48723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183279.1">
        <property type="nucleotide sequence ID" value="XM_002183243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G855"/>
    <dbReference type="STRING" id="556484.B7G855"/>
    <dbReference type="PaxDb" id="2850-Phatr48723"/>
    <dbReference type="GeneID" id="7194994"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48723"/>
    <dbReference type="eggNOG" id="ENOG502QT40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_1_1"/>
    <dbReference type="InParanoid" id="B7G855"/>
    <dbReference type="OMA" id="EYGHFWA"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837:SF2">
        <property type="entry name" value="MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="REGULATOR OF SIGMA-E PROTEASE RSEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855883" description="Peptidase M50 domain-containing protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="13">
        <location>
            <begin position="95"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="542" mass="57720" checksum="D50193B3F1D36066" modified="2009-02-10" version="1">MRVAHFPFADGLLLVLGVLWCTDGALAFTAAPLHTQSHLDSKNGVFGNGKLTDNRFFGKADTVRPISTPRGSAVGNLKASPLVALLSSPLGSVGVLASIVLVHEMGHYLAARSFGISVEEFSIGFGPKLLGFRAFGDEFNLRALPLGGYVRFPENYNATRVREMEEAAYLAAKENGALEKPDAASEILNMVTFGAVEARQQREKEQQLLQQVEEFNNLPFWKKMVKTPPQKSLDRGNVEIEYYDDPKLLQNRPWQERAVVLSGGVVFNLLLSFSIYFGQISVGPGLPQPVFDRGIVINAAPTSNAAASGLLRKGDIVYEINGSPVSVSSSPSPYEAQKSINEFIAKIRTAPEGQPIKLVVRHPNEKELVNVDVVPKKLDAAGPQTIGVLLAPNYIKSEVLRTDNVGEAASLAYKYAYSLTSQTAAGLGSLFGDLFSGKAGSSSNQVSGPIGLIRTGSEVVATQDLTTVLLFAAAISINLGVVNALPLPALDGGQLLFVIAEALTGRKVNQRLQEGITGAAVLLLLLLSVGAAVGDVSSILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9D5</accession>
    <name>B7G9D5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_49065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183614.1">
        <property type="nucleotide sequence ID" value="XM_002183578.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G9D5"/>
    <dbReference type="PaxDb" id="2850-Phatr49065"/>
    <dbReference type="GeneID" id="7195310"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49065"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232642_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9D5"/>
    <dbReference type="OrthoDB" id="49495at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="809"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1704"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1770"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="856"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="937"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1985"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2083" mass="225649" checksum="4BA053F46CA82376" modified="2009-02-10" version="1">MFPPPPPPNAGTLPSHPPFAPNLVPNSHPESTTGTNVNTTITNAGTSYTPASAVMTDPRNRSRSSRSRSPSPTMTRSVPASPRSVPSTPTRRALPRPPPRSLPRPPHRRVGSHDATTTATPSRHTTTATTSTTMTTPSGLYTPRRFKLPPTSHTRRETSSPYVTPTHTPQSSPFRRPRVSHAMEETDAVTNPSTDPWGTTGAPLADVAEPPLVPPLLPTTSNAATFTTTKTTVPEATTPTPTLTVPSSSLPPQWTEAVDVDTGKFYFVHVETKETRWERPTIDDGDTPTHQQQHHIACVSAEAPNGEEARTAVPNAAPLDQASDPIEPGWTATVDPASGRTYYYHAATGETRWEPPLARADEPTNPVSKPPSTTESAANVSEIPISLPSGWVEQTDPSSGRPYYYHNASNLTQWERPGDATLPVDEKDETTSERVVESLNPPTKPSPVTVESASVAEEPREFDRVHSEPADTEPTPDRETAVAEQPTEEQKTDPAETQTAYFLPAGWVAANDPSSGRTYYYHAESGVTSWNPPKMPGTVPEREVADETGTEHPEEKSLDPVSAYEETKSESPATETLGISTDDTISDRHGIGGEFDSVSPDSWTLRDGNSANDTVTDVTEGQSPELPNGWQELVDPSSGSTYYYNEVNGTTSWDRPLAQETTEVSVSPPEEEKHDSADIHHPRASPEDTGSANDGAMTTDPQSEPPSAPLEANVGGVLSSVPEVEAEANEGKLEEKTAALPEGWVELVHESSGKTYYFHAEDNVTSWEQPEPTRRQKNDEDERIVVPEESLYPEIPSNSDLAPEETNVAALPQGWIEAVDPSTEATYYINEVEGITSWERPRFGDTVSFINLVTENDVPEPHSNSAEGSNKAHDENDSGLEDENSLTDLPPGWAKLTHPDSGDAYYYNEATNATSWDIPESSTVNGTSAQLDEPFETTTEAFSSGGGASPRSVDGSSEYPREEANLGGDSKNLKSHVSLAGMVESENSKPFEMPEDAISTGWEALVDEASGAIYYYNKLDGTSSWERPLASDIGLDGGLIEVQEKETDIDSTVEANRMDNVTVQSLPEGWIEVMDPNSGSVYYFNEVDGTSSWDKPQEPTTDPKHLPDEETEAIVGRAAHSIATFGFGGKLCVHRVALGSPCVAIYRPYTLLPMESVVRVEERKRKASIFGPLSTSSEKSMATYLQLLSKEEKGDILWKVISIAYNHGGKLRGNDSPEKTASPEEEVVELLLQAGDIFECPITSNAPGRNVDEIQSFLLRGQRSDALKAALTGGYFSLALLVASMCERESFQHVATEFTKSSFTADSPMHTVCLLLAGNIDGLLDDHKNEDVELWAGDPEKLRFTWKGHLAAILSNRTSGWDRLAISLGDKLLEIDEIEGAHCCYLVSGCPIASPVRNARLTLLGCNFGPADLTLMTEKSVFGFEYTEAFEWSKRRQNPSSSIQSLQAFKLMYATLLADLGYQTTARHYLQDVLKCVDALPEDAGIESRPGPFSLSILSADRGGLLYHLNSFERRLTLKEVARGTPVPDVIKDKHSSRASFEDQGELSFLTTQSNMLETTTGSTIVGEALLPADEDDDAPAVGSETYESVTSESDDPIVVGPEVLPVEPSETFLESSESAVYILPPGWVESIDPTSGETFYFNESEGTSCWEKPTFDETKTEQEASMKNFNQGINNTDDVDNEEATEQPDGLYEGGHMDNTAVPNLPVGWVQVEDINGGPSYFYNEDDDVTTWDRPTLVAQEGEMGTRSIAPEREAMPSTKDVIQASHSTNLPEGWEELVEPSSGDVYYYNAAENVTTWDRPVQVPDKAERTSAVSTCKSQVSSSPDLRGGSSLKQSAMEFSGEFTENRPLSVDSKPPLLTEPVLKETINDSKGLTGSGGKTPASSFAAQDINTTQQPSFAATPLRQKSPGSTNVTPVRVDKAPTAPSSAPANLEHGSNKKRGSFFNFGIQKRVAKWMNPDATLADPGEEMKAYFDEQRKVWVFPGEDPDKKASPLAPPPTLSATQRPLLEPESRPAFQPNDPLAAMMAPPRRGPSASKSRSMGAAPGSFAGGPPIGFPGSAPNGNASGAPPQFAVFQPKPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAF9</accession>
    <name>B7GAF9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
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        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAH7</accession>
    <name>B7GAH7_PHATC</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002184039.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr49408"/>
    <dbReference type="GeneID" id="7195902"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49408"/>
    <dbReference type="eggNOG" id="ENOG502TKPY">
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        <property type="component" value="Chromosome 22"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
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            <end position="83"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="888"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="116279" checksum="5E5EF86C75AE451C" modified="2009-02-10" version="1">MNSSGHRRLFRWNRDKHGDSFDASTEGGGSSHALPVSKSGSPVPSDSIPKSFAQSRINWESGKKYDESSQDFSGHRSRDDSVVETKLWRNKLTKNLRGKFSPRSGLQIRKRRDKKDLKEEAESRFLRTTSLSDVDDTLTRNDSRGWHKRNGHPRNLAHAKKRGDDSLEFARKQSPPSSTVFFEQGMYSAASVEELGYETMTGFTDAPKESDQQLEMKRANYGTGHSKRKFRLRPHHCFEKATYMTEEDIYSDSIEPSQSFEFLKSYLAPTAFTEPKGERDGKIEESYGSPETDGRVGALRVEVLGCVSLARQKPDVATYLVCGDSAFCTDVISGYRSPMWPSASKRAAVFPIHHAFSRLYIGVFDVKARKSNKQTDAFCGRVTVDICSLRPGTEYDITLALRASTFVYDRRRRGVVRLRFSLHWFSERGAILSYFNQPRSLVQACPLVSGSPVIPCAEPRTFRNLALTVHGQDLPGKYSRSAFRATMREFNLYQVNIRHLLKTSVIEAVLYEKPIVSFCLFLAGMHCVVSNSVHMVPPYFLAYLLIQLHESYQHYVQSSVYNCGYKPLTFFEVFQALIFNTTGRDRMFESISVAKQAKQRGNIRQHKQLADMDSDRGEGGLVTHPPDHQEFPFSDRDAYPNFGVDDALAPSLKKGRAIPKTDPSGYVDGISSDESGDADNDDETITTETGMDDSMFHLDMEGEDDGLEPDDHLELASQSNLPLAASNRRRIKLGPAQNTDTSAAVRVPPQIHLKKMENIFHKLSKKLSVELVAAPMDRNLGGTVDTSHLAMRGSLALTTEALQAQEKLGKKAIYDEFDRLLGLETRTANPVLRIASAFLGPLMRIIRNIFLRTHLENKAAKTPKEHREKTGNKDEAYPTEQRRDHKTSELQLGVSSNSRLDHRKVFFRKNTSRELSTDKPHLIGPLYQDERPVFSVQHGSVASRKLRPRSVAIPYNRLRKERFYDWPPDPTVSRATPLHFAYGEETERRRRDNIFSSDLVMSLQERDKNENRIFRQRLLEASLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAU8</accession>
    <name>B7GAU8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184141.1">
        <property type="nucleotide sequence ID" value="XM_002184105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAU8"/>
    <dbReference type="PaxDb" id="2850-Phatr49509"/>
    <dbReference type="GeneID" id="7195732"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49509"/>
    <dbReference type="eggNOG" id="ENOG502SK44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402543_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAU8"/>
    <dbReference type="OrthoDB" id="42940at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="786" mass="85006" checksum="E59E328B9E2EAE0E" modified="2009-02-10" version="1">MSLATTGGGGMGSAGGGGGLMMAHSTGGTMSAATGPPPPPQASFDGGPAPPPSGLSTKQVKSVAHLPLVAIDLHETQPHIALFPPKGEDPAAGDVLPVLVGKMKGNVVLKANESSHKTLRKWLTKSKGYSSLQADSLATANETSSVVVLEKPYRWLGLRRLNDAPTFLRDSVDSEQTNSHAIAEESSTEPGVTFGIGTLDGSQPAGDDFDRVVCKVRLSSAKKTLTVLPEEATQLLIHQAQYHVAHKHQQLQASTSESSDHDEETVLEYPVSIALPSWATHDAAVEALTDSVGVGNTVILARSVCALAGALLPHPEGKANPVLDRLQKVRTALHKEFSRLQVQDPTATFKDDMLVLLVGIASDGIEATAVQISNLQTSQMSCLFGDFDILSNVAYQTNNPVSKVALCLSELEANLDAIAPDSDGPAVILTYGFTGSQDVLKQKWDEIKSQQNEWSKVPLIATKSEAVALGAAVLGAVSHGRISVLVTKGKKTKADLALTVHNVAPVAVGVQLNYFGGSENDWTPVKTIFDFDRRVPAGPYPIDLKAAECVVQRETKNVESLSDEDYLKAIKDNEGAKGIPKREESALNLQVQIVQKWTRDGEWKKVGSPMEPLVKLDADENRVACESVALEISLGATGMIMTNLNGERESVVQATKSARNNAIRYYVGILLAILVFGGLLVKSYWEDHVFKRDTARLLAYYKHIIPGSIQDGDYDTARYLVWKYRGKSDKLWKNLEKKYGEPVLDTHEWPDTAVDDDARRPLNEEHETVELDEEDEKETKQEEPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB16</accession>
    <name>B7GB16_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_42307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184291.1">
        <property type="nucleotide sequence ID" value="XM_002184255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB16"/>
    <dbReference type="FunCoup" id="B7GB16">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GB16"/>
    <dbReference type="PaxDb" id="2850-Phatr42307"/>
    <dbReference type="GeneID" id="7198187"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42307"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GB16"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001794">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="49032" checksum="BD80E106954FD317" modified="2009-02-10" version="1">MRADATTEAHGQGPQQPHLAKQDAATVDPAQLTALSPEVISRQATINVGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGPLYTSRGSSHADIFTEGGRTYHLRRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNETCPQPQTSEHLAAVEIMRLEHILILQNKVDLVKPDAAVAQQEQIRKFVAGTVADAAPILPISAVLRYNMDVLCEYLIRRIPLPVRDFTSQPRLIVIRSFDVNRPGQDVSKLQGGVAGGSILQGVLRVGDEIEVRPGIVHKQDDKIVCVPIFSKISSLYAEQNDLQFAVPGGLIGVGTKIDPTLTRADRLVGQVLGLKGQLPDVFSEIEISYYLLRRLLGVKTSDGGKQAKVQKLTKNEILMVNIGSTATGGRVSAVKGELAKITLTQPVCTEEGEKIALSRRVDKHWRLIGWGQIRKGNVVEIAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB94</accession>
    <name>B7GB94_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184426.1">
        <property type="nucleotide sequence ID" value="XM_002184390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB94"/>
    <dbReference type="PaxDb" id="2850-Phatr40375"/>
    <dbReference type="GeneID" id="7198265"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40375"/>
    <dbReference type="eggNOG" id="ENOG502SPJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525303_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB94"/>
    <dbReference type="OMA" id="HERARWK"/>
    <dbReference type="OrthoDB" id="45213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="519" mass="58222" checksum="15A34B1AF5413EB5" modified="2009-02-10" version="1">MTRPQFTIRAFILAVVVLLVLYCNSGVYRPLRAPNGTRSQPVAFPNSQTTPLGSYAIAAGELPGYTGWGRPEFTLAGYFTAATPKGDTISAGDPYIIELQCRGHADCQTPSYFYVRAYGPAILTGRIEARGKGGYRALLYPVDPGVYTVEIVITISNPPPFDVFPLASKAAPILYEGYLLQDFPTTLTVLPNKMDHFTKLPVCNAADLLNDRSIYPHERARWKVVDQIRSKHHQSNTGDGTQVTFPAYQQSYNSLGVVADYQFHNCRLLVIPYRGENVTFNPFLCLQEPTHFILIGDSTMRIQHQIFQQYLSLPEMKHHSLTFIELYGGILRCNTYGPILEQELKVELERNSKSQAHRAVLFNTGLHDIHRLCGTEWEKDRRTYLTDPQLPCVEQYRRGLADLIHVVGTLPAAVKLFQTTTAGWPKYGNFGINWDPRYGQGLPLDASFVEYFNTIATTLLESHPYIGVVDGYWISLARPDNREIGPRAAIGPKLSHPGIEVVHAMVRIWSMVVLRNLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBB0</accession>
    <name>B7GBB0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184435.1">
        <property type="nucleotide sequence ID" value="XM_002184399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBB0"/>
    <dbReference type="PaxDb" id="2850-Phatr49639"/>
    <dbReference type="GeneID" id="7198272"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49639"/>
    <dbReference type="eggNOG" id="ENOG502R6GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047078_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBB0"/>
    <dbReference type="OMA" id="NFFIGMH"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855667" description="TauD/TfdA-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="106"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="435" mass="48433" checksum="F076E03A9C0A112B" modified="2009-02-10" version="1">MKLQLASLALWASSALAFAPNSLPSRNNRAVGYVPSSISSLHAAALEPPPLSPLTQWGDRIENIRALQAELKARELPPFAPELSAVKDCGLAREDTEGQLAYVRDNAMRIKTMMQEHGAVVFRDFDLMKTQEGFQAFYAAIGMKACLDPLHSVSARPTVDGQKNSPVYEAVNKESRKNFFIGMHNEFVGTRAPRAAAFVCFKAAETGGEFLVADGRRMFRDLDADLIEELYNREIRYSVMELPFFGWIDNLPSFVQQPAMNVVRGAVSAAINAKVDFDVELLWGEGGYDGTRMLQARAPSQPPIVKHPVTGDPTWFCNVHSHSSKLRHQRESIYGAERFEDGASQINKSDMFFGDDGELSEAQLKQLDEVTVKNTRYVKMTEGDVVLLDNYKTMHGRNVFDGTRKHGVAWFEGWEGEADMKQQFQAEGASQKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBC8</accession>
    <name>B7GBC8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184443.1">
        <property type="nucleotide sequence ID" value="XM_002184407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBC8"/>
    <dbReference type="PaxDb" id="2850-Phatr49657"/>
    <dbReference type="GeneID" id="7198301"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49657"/>
    <dbReference type="eggNOG" id="ENOG502T7RF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311595_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBC8"/>
    <dbReference type="OrthoDB" id="46346at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="643"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="945" mass="104124" checksum="5DC42F713C8EE0F5" modified="2009-02-10" version="1">MLSGIMRNENSEQETSTRDIAATADKDGLATKQTSEQGTTPEGGNTKLMEQQTTPVNDDKILEKDDPPPEIIPDPFQPIPVHIETTIRMTLACFAAYSLAVADLPSIIPSTQSWIIGILGPTIVMRLPTVLATLGGIGLCYTILFFGLASITVMLYAVTVSDGFFIAVVAIWSLWIAPLRVGSLAKLTWVVAPVLAAFVGIIGLDLHRVVRDGINLKLSSELIQDLIQELAPGAMGTLPTSELVASLQEINLEALVQSQLDDATLLARAAGALDNLTAFLDLVREGILLLIQLLSESGQQQGAIAVTIPLGLFEGRDVFLSLSEDRDLFISLEGGAYLIRLFWTAGVMNPIAVFPNFIVAGTWAILCVALSPLLPPFRKTRFLIARRILPQVLYDAAWYIQGSSMDEFEGVDQRKTADIVAIHRRLVLASTSLRSGTVAAATAFEPRCFANVGTMPRFSVQNVATKALAFRAIGFPDCLENRQAAKQAFRGTARALQKLQSHDTLDLQKVQVQETKMWNFEKDIEMIRSTTDNWIQSMTASEKNISLKEGITNSLKCGAMWFALPVALLWRVLQTPFIPIQIVQGKYKTTMAKIFHCIKFAFGFTLLAIFSVYWESYREIDVSSPSQQTNFELVVGTPPSSFAGWELLAYSFATMPTAEGTIKKCVMRVVGTCCGGLSAWLLILAVGDNPYGTVAWLTGTAALGILLSVEKDESARFGQSRDFGYAGFYFVLTQSVIVFDFRVGLGSRNELVANRIAANLLGIGMACVLAMIPPRVLGARPEYADQLLTKISQSLDQTMLLAIDEPPSEKYTELRITHEEEASLLYSTATYLLEDANRLSKFPIFKVDHQLEELMLELVTTSCILSIWWDYIARLISEDEKTSHKWQTAFKAVFELSLHVCVTSKTDVTGSVLDEEHRFLANAFAVVKRRLETHARVIKQIREMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBF6</accession>
    <name>B7GBF6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_16074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184456.1">
        <property type="nucleotide sequence ID" value="XM_002184420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBF6"/>
    <dbReference type="STRING" id="556484.B7GBF6"/>
    <dbReference type="PaxDb" id="2850-Phatr16074"/>
    <dbReference type="GeneID" id="7198162"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16074"/>
    <dbReference type="eggNOG" id="ENOG502S94R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1630263_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBF6"/>
    <dbReference type="OrthoDB" id="10261135at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13831">
        <property type="entry name" value="HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="DNA-BINDING PROTEIN HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175:SF3">
        <property type="entry name" value="DNA-BINDING PROTEIN HU-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="90" mass="9609" checksum="B9FD904F80F54B47" modified="2009-02-10" version="1" fragment="single">KADFVTALAEQTGQTKKESEGTLQAVLDILQAQVSEGKKVTLPGFGSFVLKSRAARKGRNPQTGEEMQIAASKSPGFTPSKAWKDMVNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBM9</accession>
    <name>B7GBM9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184475.1">
        <property type="nucleotide sequence ID" value="XM_002184439.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBM9"/>
    <dbReference type="PaxDb" id="2850-Phatr49712"/>
    <dbReference type="GeneID" id="7198397"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49712"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238985_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBM9"/>
    <dbReference type="OrthoDB" id="48673at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="184"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="973"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1625"/>
            <end position="1635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1765" mass="197684" checksum="F1B414255CEF377B" modified="2009-02-10" version="1">MESLCAGDSGILGESSSSFASVRDDTVRDVSASTSDGEEEVDAVEFALNGGMQGTEQYIKSAAGNVTSMAFDCEDSRQDNRSRDTACGRPDEPVPNRSRKRNSAKDRHPRTTTPSKVQSKNSISHPLSPFSPLLLQKQQRKRRTRARPVDQHHQPNTTSPGVPWQDDDNDDQDTVIGTLSLNATRKVSVIVHVRNPIASEKEKDKICLFPLLRKHDEATAILSTSEAALSPTSATLQSAGHTRELIVVNPTAFGKLIPSKVTMETARLVAQMANVEDWARSFRFQQVMWPGNELQALQNLTQAMVNDVMAPGSIASRTILAIGSDAASKSTLLFGSVGTQSIARVLATTAHDLTPSDILSRYGLIGIAVSQLLDQMPSHAIVTLSVLEIAPDDVLHDLLAARPFNSSSRLQFRYSNSTNAMSESGGGAVVHNLTNVPLDSLKSLGHLLRRAFTAARNPKRAHSPAHIMATLKIWQSNGTRNDSTMEAAHTVVQFGDIVNACTNSRRDAALKQSVTTLGGVLRGVLLREAGNDSPWKFRESSLTKVLQRYVDHLDGKVVMLACTSPLSDVYDETLATLRFVSNLLYSPNRAASSPFHRREDDTAPTSPLSDTSSAMSLMAAEFSGSDRQTLLTNLLSDPRQRLAKVWKQKARENPANAELQENKNEYTPTQYELIEIATLDRAETRLPRAEEQSSTSQIVQPEILIPTPIAANRNAMRNKCRSWRPPDTDGPFGKVLEDCDYAAVETSFPSDLSERDADVGHNCMDEPSPLTIDTKDPPFNLDTSYTLDEMAERVFKNSKMKDTESKTRAPSGYLEGPGKEPSNVHMDERLAVGDTVVGEKHALYNSLHKQTGNLPWASREKPSSHGLHEVTGMQSNTGTLAHLSKKERQEEKESFPDKKDNAKVDPPQDLLLDNREERDSTLMHDPRQVFSTKEGEDRYVSFSSANHQASNVPLRHNSDFDRKFPSLMFEDKDPKVERSDAEGASTTDPCAGRHSALFGNSTEPNNRKDSGNKSSLAHTPFESDSYNAEIDPSLETSHHILLVNVPEDVTVGHSAHPDVTVGRASGNEIFDRSSVDGASRVSAEAQLLRESLSKAKAERDSAIQKYQRLEEEKTARDEEEDFLLKKLRALTDERDGAFRKLEDLERKLTSEAKLKSDTREAEWNKLTTERAKAINQIEELEASCLEAQESRDILREALEEREEALRLIQLSEKDRIRDAEEHDKALKEATLQIEVLQDQTVKMCADRGELVKIAEEAIGTNAQLEQKIVELEKEVSTNVLSSVSKDEVEILEKENLKLSEESQELRKQLSQHKLQLKENGLSLSELTFTVSSLEDERAQLLNNKKAKDDEIRRLKRELTSKDIVEDRASALQRQLEHQLTLGVEWQQRETDFNRTIQNNITELEQLESAVKNLQAKLDERNEMHSQEVESDKSQIALLLNKVSYYERERLSAAASVEELELKLGSEIRTRHKLSSDLKQAQIDLHSRLADVQELSSNLKQLLVEKDEDERKVARMQLALQKFQSETRTRVKMVVMHRDEAANLLDETLTENRALTEKLQELRQALEETQHARVDWRSNSLTASRFQADLDDMVSKNKALSQRNQLLETQVEELLQQQPQKQSFPRNRENDNLRDHDKYRGIDSEHQFGITNSLKRRNDSGSGKHTIQRRDEDGFDHGALHLEPFSALPGHALANSESSLHARAEEVAAYLALSAKMTVEKSQTEVIRMQHRLHAVEDTKDTEIDALKRHVRRLERHLENSNWPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBY6</accession>
    <name>B7GBY6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_7780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184532.1">
        <property type="nucleotide sequence ID" value="XM_002184496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBY6"/>
    <dbReference type="FunCoup" id="B7GBY6">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBY6"/>
    <dbReference type="PaxDb" id="2850-Phatr7780"/>
    <dbReference type="GeneID" id="7198465"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7780"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1221719_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBY6"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="8">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="122" mass="13448" checksum="B4D95B0B521E73D5" modified="2009-02-10" version="1" fragment="single">THQSQLLVTDSCWNRVRTLAARKQQSLDDVYLRVFVDAGGCSGFTYQFELDQEALAADDVVFVQPHSDGNGTARVVVDETSLNYIRGSTINYVQEMIKSSFEVQENPQSESACGCGSSFALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC17</accession>
    <name>B7GC17_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_40650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184638.1">
        <property type="nucleotide sequence ID" value="XM_002184602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC17"/>
    <dbReference type="PaxDb" id="2850-Phatr40650"/>
    <dbReference type="GeneID" id="7198573"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40650"/>
    <dbReference type="HOGENOM" id="CLU_468914_0_0_1"/>
    <dbReference type="InParanoid" id="B7GC17"/>
    <dbReference type="OMA" id="HYSHCKE"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39321">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39321:SF3">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="582" mass="64167" checksum="A9855DDBB9AFF6A1" modified="2009-02-10" version="1">MEDNLTSLPTNGESLLPTDVPTDRPLSIGVFGGSFNPIHLGHVLLAITTQQTKPVDQVVLVPVYKHAVKRDLLPFDDRVRMCRAAVGSFGQHNRAIVVSTVERRVGASNGAMLRALQQEYPEGTRFWWICGDDFFRWMERPKGLETLAHVSGLIVQRRLHKRANGQLFQEDLDEARVRAKTLQLDIHLDFIYGELPHFSSTLVRQAPGSWRSFLPQAVAAYLDARPHLQEQLLANLQADATAEAAQTVLSGEQPVTAASNTACSTTTTSAAAFKQAGLWVMRGLDMVHMLQYERGMTGLRLSTGTTQKYQQETLEEVQRNTDRVLREILDAHAESDQLVLLPADDDWPEVQALAAELQQVPTWLTRDRATLARRQLVLTATPGVEGWAARYSLVEKFHARLDLLTQSTVRALVEIRANLAVAQAQPTPSRSVPELLRSWCQGKEALGRLRAFVCAGGPDASTLVRESLATRQQLVRVMEAKDRCIARVLILEAGVSTRLAAPDALHRMLSEVTKAEWSLMGCCSYVANQPGSIQLVHQQLASGSAPSDEPFSVQHFFEASSTAIDFLLTFAKALAASACSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCF7</accession>
    <name>B7GCF7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="e2304833120" last="e2304833120">
            <title>A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs.</title>
            <authorList>
                <person name="Oh Z.G."/>
                <person name="Ang W.S.L."/>
                <person name="Poh C.W."/>
                <person name="Lai S.K."/>
                <person name="Sze S.K."/>
                <person name="Li H.Y."/>
                <person name="Bhushan S."/>
                <person name="Wunder T."/>
                <person name="Mueller-Cajar O."/>
            </authorList>
            <dbReference type="PubMed" id="37311001"/>
            <dbReference type="DOI" id="10.1073/pnas.2304833120"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.00 ANGSTROMS) OF 568-576 AND 466-473</scope>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184702.1">
        <property type="nucleotide sequence ID" value="XM_002184666.1"/>
    </dbReference>
    <dbReference type="PDB" id="7YK5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="a/b/c/d/e/f/g/h=568-576, i/j/k/l=466-473"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCF7"/>
    <dbReference type="SMR" id="B7GCF7"/>
    <dbReference type="STRING" id="556484.B7GCF7"/>
    <dbReference type="PaxDb" id="2850-Phatr49957"/>
    <dbReference type="GeneID" id="7198649"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49957"/>
    <dbReference type="InParanoid" id="B7GCF7"/>
    <dbReference type="OMA" id="MVKWSPR"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057583">
        <property type="entry name" value="PYCO1_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24428">
        <property type="entry name" value="PYCO1_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853230" evidence="2">
        <location>
            <begin position="20"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7YK5"/>
        </source>
    </evidence>
    <sequence length="583" mass="56615" checksum="25752778D28D1781" modified="2009-02-10" version="1">MKISVKSATLALLMVPTTGFLHAHPARSVETAFHAPTHTTWKTGARWGRTPRSGSSGFSPQSAGSYAGRSAFGRDSTYGSSTSVGSATAPTAPGYSSMPAKVYANAGPNQKYSMTKWSPQNGASVNGGGPSAYSSSNGVPAGGNGAMGTGYNPSAQSNNAYQSSAPATGSAAPTYSSMPGQAYAGSGPPKNYSMVKWSPRGGATGGSIGTGYNPAQPASAASSNDAYTAPSTGSGAKGAPSYSSMPGQAYAGSGPRKNYSMVKWSPRGGSSRASNGGGGGSPTYSSLPGQAYSGSGPGKNYSMVKWSPQGGSSVSSNRGGGASAGSLGTGYNPAQPTTAGGASSNESYSAPSTGGSSSGSTPSYSSMPGQAHAGSGPSKNYSMVKWSPRGGSSRASNGGGATGGSIGTGYNPAQAAPAASSYGSSPSSSNSNAYSAPTGNAAPSYSSMPGQTNTGSGPTKRYAMVKWSPRGGSVVSFNRVGGGGGSMGTGYNPAQAAAPPAAAAASYSPAPPAPASSGYGNLASEWASMNTEKASPAPASSAYGGGAPSPAPAPAPAPRSGNAYGNLAAEWGSMNQGDSSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCJ6</accession>
    <name>B7GCJ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184820.1">
        <property type="nucleotide sequence ID" value="XM_002184784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCJ6"/>
    <dbReference type="PaxDb" id="2850-Phatr49991"/>
    <dbReference type="GeneID" id="7198699"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49991"/>
    <dbReference type="HOGENOM" id="CLU_611750_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCJ6"/>
    <dbReference type="OrthoDB" id="44984at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51850" checksum="EBF73DD97D966609" modified="2009-02-10" version="1">MLSRIRSLLACFILMTAFTSLIFTIKVERQRHSDLASIQAPRQEARHSVGSPSSREKRKSHETPGKNTNTAYSQRSRKTRESPRQAHDRTRPGFVPPFREQQNTKNLDRPAFHDLLGPNRTIVGDVQFLLDFAVIGFGKCGTTTMMNWLADHSEVQCFRQEIWELMYGNVDTLISLLYFDLLPGSEYKRGYKNPGEITQPHILASFRRYWPRTKLLIGVRHPVKWFESLYNFRVQNLHQQGDEMPHPNRLIGRCSVGTKNTCTDKGNFAYSLLRLGKTNKSGPRMATRLEDGIVGHYRRQWYNVSQVPYMPNPVFLFEVSQLADTNVTRASEFRRDVQDFLGLRQPLPDVPHDRPGKNVENVTEQAYKDARKIDICNDEFKPVRRDLMRVAHSNSEWLRTVFLKHELDVSFSSPAYLHEILESWSRDPCRIDAELIVPEGVLSLRNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCQ6</accession>
    <name>B7GCQ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_40901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184922.1">
        <property type="nucleotide sequence ID" value="XM_002184886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCQ6"/>
    <dbReference type="FunCoup" id="B7GCQ6">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCQ6"/>
    <dbReference type="PaxDb" id="2850-Phatr40901"/>
    <dbReference type="GeneID" id="7198736"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40901"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392068_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCQ6"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="405" mass="45774" checksum="2B1D064AD1664781" modified="2009-02-10" version="1">MVVNAFEVSGKIDYTKLVDKFGSNLISDSLMDKLEALTVGKGRVPRMHRFLRRGMFFSHRDLDTLLRQVEAGAPMYLYTGRGPSSQSMHLGHLIPFLFTKWLQDALDVPLVIQMTDDEKFLFKGHYDDQTGDNLLDFQSLTMENARDIIACGFDYNKTFLFSDLDYVGSMYPNIVRIWKAVTTNTVNGIFGFDGSSNIGKIAFPAIQAAPSFASSFPVVLEADRNSNHLCLIPCAIDQDPYFRMTRDVAHKLVHKQHGLGGKPALIHSKFFPPLQGAEGKMSSSNTNSAIFLTDSPDDIERKIKQHAFSGGRETKKEQQELGADLEVDVSYQWMRFFLEDDDELEKIGQDYGSGSGEYWNTGKVKGRLIEILKELVAEHQERRATITDEEVRKWMAERSIVKNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCZ2</accession>
    <name>B7GCZ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_16560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184959.1">
        <property type="nucleotide sequence ID" value="XM_002184923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCZ2"/>
    <dbReference type="FunCoup" id="B7GCZ2">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCZ2"/>
    <dbReference type="PaxDb" id="2850-Phatr16560"/>
    <dbReference type="GeneID" id="7198914"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16560"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GCZ2"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28922" checksum="D535F687F2854632" modified="2009-02-10" version="1" fragment="single">LRTDGRVWNQLRSSRLSLTRWENGATCTTQWGKGTRVSCTCTAELLPPNPDRPNEGMVALSVDLSPSASTAFRQAAPVTTGGSILRSLERVLLTGGALDTEALCVTPQYWVWKLSLAVTVLDDGGNLMDASVLAALAALRHYRKPHVELAAEGSNSGVPPRWIQSDLKEPVPLPLHHTPLSISFALLPHDTAAQSTASAKVTLLVDPDAREELVSVGTLSIAMNVHGEVCLLDFGGGCELATERLREAYRLAAQHVQDLCQALETSLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDD7</accession>
    <name>B7GDD7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_16704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185112.1">
        <property type="nucleotide sequence ID" value="XM_002185076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDD7"/>
    <dbReference type="FunCoup" id="B7GDD7">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDD7"/>
    <dbReference type="PaxDb" id="2850-Phatr16704"/>
    <dbReference type="GeneID" id="7199008"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16704"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="InParanoid" id="B7GDD7"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000541">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="8">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="10">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="9">
        <location>
            <begin position="827"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116829" checksum="C397DEAF495D3BCE" modified="2009-02-10" version="1">MVSDTESVASAKNKWDDVISTGASSRRRKRWDETPVMAASSSVAATPLVTTGCRSKWDETPVLASGGVGVIKTPTLAGARNRWDATPLSTQPLAGASQTPMGTPLDKAMLLEREMESRNRPWTEGALDAILPSEAYNIVRPPSTYIPLRTPGRKLLATPTPMSMTPAGFQMEVPAEQRIDASVQDIREAYGSLPYIKPEDMQYFGRLAEEVNEDDISKDELKERQIMTMLLKIKSGTPPQRKTAMRQITDKARSFGAGPLFNQILPLLMSPALEDQERHLLVKVIDRVLYKLDDLVRPYVHRILAVIEPLLIDEDYYARVEGREIISNLAKAAGLATMIATMRPDIDSPDEYVRNTTSRAFAVVASALGVPALLPFLKAVCQSRKSWQARHTGIKIVQQIALLMGVAVLPYLRELVEIVSHGLVDDMQKVRIVTALTCAALAEAAHPYGIESFDPVIRPLWKGTMEQHGKALAAFLKAVGFVIPLMEENYASHYTRLVMPILIREFHSPDEEMKRIVLKVIEQCVATAGVEPDYIRTEILPEFFRNFWIRRMALDRRNYNQVIETTEELANKVGCSDIIIRIVDDLKDDSEPYRRMVMETLKRVLNNLGASDIDERLEERLIDGILYAFQEQAVDASSTGSNSFGRESQVMLEGFGTVVNALGERCKPYLKQIAGTIKWRLNNKAASVRMQAADLIGRIAVVMKACGEDQLMGHLGVVLYEYLGEEYPEVLGSILGALRAIVNVIGMTKMTPPIRDLLPRLTPILRNRHEKVQENVIDLVGRIGDRGAEFVSAKEWMRICFELLEMLKAHKKAIRRAAVSTFGFIAKAIGPQDVLHTLLNNLKVQDRQMRVCTTVAIAIVAETCGPFTVLPALMNEYRVPELNIQNGVLKSLSFVFEYIGDMGKDYVYAVTPLLEDALMERDPVHRQTACSIVKHLSLGVVGLGCEDALLHLFNYVWPNIFEESPHVIQAVFDAVQALMVALGPNVILAYTIQGLYHPARRVRDTYWRVFNMLYIYNADALVAGYPSMRDEGGNTYKRTSLELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDM6</accession>
    <name>B7GDM6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185156.1">
        <property type="nucleotide sequence ID" value="XM_002185120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDM6"/>
    <dbReference type="PaxDb" id="2850-Phatr50304"/>
    <dbReference type="GeneID" id="7199053"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50304"/>
    <dbReference type="eggNOG" id="ENOG502SHPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316550_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDM6"/>
    <dbReference type="OrthoDB" id="37418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="742" mass="80904" checksum="33C8B95CD8AB0F39" modified="2009-02-10" version="1">MATMNGFDMGFGANAAAVFGSLEMDGDEYVRCMLCHSAGVDVRVSSCGCTSHARCIQLNPHGSLSNCPFCTKPTQGLVLFPMSFREIDEAHRTASALPPKPQNRGRKRKTGADLIEDKGYVAERRTGRWTNEEMSFCDKLMDKFANGDLPVADGVKLNEFLGNMLKSKQSRLTKKMKNAKLSSKTYQKGIGCLTATDASEFSDLEELFFQAIPDLQERAEIKFHMQKEWREQFSRVCATVGQPLDADSWLGSVEEMDRRASQTRDAARMAKRKLMMGVALRTDSQNADDGVFIEKTEAEARAAGSTYTSERDVEDEMLSILAEDKAAAQAIDLNGKSSLLHSAPFLSKTTSYLQRLGIPFEHVDLWVPSFVPGDGEDLDSTTCRLCFAGSATVDKVIEQDGKSGRSLTTEERFNLFAFGDYSQKFSFDVGCGLPGRVYESGRPTWEQSVHNAPHNHFERCGGALQWGIKTVVGIPIASPNVGRIVVTLYSCYDRPKDEDLVSRLSEEFTRLMPSPKWKLVVDIGDVEETPSATYATAGTTSSTAAQVDGHDASDNSKESIDISIVASVASNPVEVASSNPAAISAYSGAEARDPRIEQVVAMMGDFMPSDPNSLMAPYMQGFMSLRLLLLRHSLTSEESELSRTILDSFSSYTAGGRDRGDIAIMLARDFMFLSHQQQQAHHPSFLNLGENMMGSVAGAHTTTNTGLSLFGLPSTSSSLQNSPALTPIPGPGTNDSMSIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDP5</accession>
    <name>B7GDP5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_50318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185248.1">
        <property type="nucleotide sequence ID" value="XM_002185212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDP5"/>
    <dbReference type="STRING" id="556484.B7GDP5"/>
    <dbReference type="PaxDb" id="2850-Phatr50318"/>
    <dbReference type="GeneID" id="7199063"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50318"/>
    <dbReference type="eggNOG" id="ENOG502SZFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626246_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDP5"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="310"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45379" checksum="D0780E67F71C39DF" modified="2009-02-10" version="1">MVHRQPTVPTYDAQPLTDAFTANRRLQYAVLRNLRELALQKANNRAQAAKLTAQASRRRMEALCVPAVIGNPYRHSIWKNRGFFTGPDGSTPPPNPDTLKRRKLEQESFYYHLQPPWSSKESNTLSSIVQHLRIESTTEEAIIEGQEQQIDFLQVAEQLQQQRVKNVSLSSSLPKTALPRTAEECRVHYEQLIRKRDMITKAELQRIVEQVEAASKTPDWFAIGKELSTATKQRTGWECFLAYQNMLRQSCQSSTIVFTAEQDELLLKYVAAMGPQLVLDGSQVAYMAANIAPDKPRSKIFKRLNTSLLNPKLKHDAWSDEEERKLAIVMKMYKSSPGNDLHQLVYHLPGRSMKSVVDKWHRTLNPVYSTIPFTAAEDEALLQAARQEESRERRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDU6</accession>
    <name>B7GDU6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_51277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185271.1">
        <property type="nucleotide sequence ID" value="XM_002185235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDU6"/>
    <dbReference type="FunCoup" id="B7GDU6">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDU6"/>
    <dbReference type="PaxDb" id="2850-Phatr51277"/>
    <dbReference type="GeneID" id="7199181"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51277"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDU6"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="69"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="41534" checksum="F76680432ADE03E2" modified="2009-02-10" version="1">MSDDIQKKIEEIEAEMARTQKNKATNYHIGTLKAKLAKLRSELTNGPGGKSAGSKDAGRGFDVSKSGDTRIGLVGFPSVGKSTLLTTLTGTRSEAAAYEFTTLTCIPGTMKYKGARIQVLDLPGIIEGAADGRGRGRQVISTARTCNLILVVLDSAKPVTHKKIIENELFSFGIRINQNPPDIKVMTKNAGGIGYQEMVKQTQGMSADVARVVCKEYKISCAEIILREDVSVDQFIDVIEGNRAYIPVLYVFNKIDAITIEELDILDQMPNYVPISSQHEWNLEELMEEIWHRCSMLRVYTKPKGQIPDYDEPVILHAENPTIEEFCNRLHKSIIDSFSHAWVWGRSAKHQPQRCGKDHVLADEDIVQICKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N4</accession>
    <name>B7S3N4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_bd1166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="DS999262">
        <property type="protein sequence ID" value="EEC42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176173.1">
        <property type="nucleotide sequence ID" value="XM_002176137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N4"/>
    <dbReference type="STRING" id="556484.B7S3N4"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1166"/>
    <dbReference type="GeneID" id="7204927"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1166"/>
    <dbReference type="eggNOG" id="ENOG502SNMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1121926_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N4"/>
    <dbReference type="OMA" id="MTIRCRS"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044208">
        <property type="entry name" value="FKBP19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47717">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP19, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47717:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP19, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002862895" description="peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="248" mass="26996" checksum="92E718F30A4A55DA" modified="2009-02-10" version="1">MNKIPLSLLILFATACYAFAFSQRWKSKDRRYSSQLAAMDSGSSPSRRAFLSAATNVVTTVGIGATPAWAGIDPSALKNLPVEGDSAGTVTRLQQIENLQKPASDLEDLPYTGLPSGVSYREFRQGKGEATVQDGSRVAVEMTIRCKSFATNIEPGGLKYFSTKDDTDFNELAFTVGKGDILPGLEEGMIGMRKGAIRRIEVPATMVFAAKKADQLPLPTTKDGKRRFESLFKTDATLLFEVLVTRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7S432</accession>
    <name>B7S432_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_bd475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176328.1">
        <property type="nucleotide sequence ID" value="XM_002176292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S432"/>
    <dbReference type="STRING" id="556484.B7S432"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft475"/>
    <dbReference type="GeneID" id="7205108"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd475"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014254_3_0_1"/>
    <dbReference type="InParanoid" id="B7S432"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000104">
        <property type="entry name" value="Alanine aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="76"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="464" mass="51022" checksum="BA1CDC6BD881A64D" modified="2009-02-10" version="1">MSQSLRRMQYAVRGEVVLKADKLAAEGRKITYTNVGNPHAVGQQPITFYRQVLALCDLPASCGVDHPNASQLFPLDVLERARELRGIVGKGGTGSYTNSQGLAGIRKHVAEYILNRDGHSAYEGDIFLTNGASTGIEFILNGLISHDHDAIMIPIPQYPIYSALITKLGGRKIGYELDEELGWTVTEGELQRRLNEAKAKKLNVKGMALINPGNPTGQVLQRKDLEMICRFCARNGILLMADEVYQRNVYVKDRKFISAKKIAVETPGCENLELVSFHSTSKGLIGECGRRGGYMELHCIDPYVQSQIYKLASSALCSGVDGQLMTSLMVKGPAEGSDSYTLFVEEERAIFQSLQRRAKKMVDGLNRIDGITCNQAEGAMYAFPRVIIPQSAVDAAEASDQTPDTLYALSLLEETGICVVPASGFGQKKGRIGFRTTFLPPEDDLEVAIGEMARHHNFFCQKYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0D1</accession>
    <name>ATPE_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase epsilon chain, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874406.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0D1"/>
    <dbReference type="SMR" id="A0T0D1"/>
    <dbReference type="STRING" id="556484.A0T0D1"/>
    <dbReference type="GeneID" id="4524603"/>
    <dbReference type="InParanoid" id="A0T0D1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000022">
        <property type="entry name" value="ATP synthase epsilon chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF10">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000275226" description="ATP synthase epsilon chain, chloroplastic">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <sequence length="133" mass="14354" checksum="D756E0B27970506D" modified="2007-01-09" version="1">MVMNIRVLTPDRVICSTTADEVVLPGLTGQVGVLDGHAALITALETGLLRIKLNDKWTPIILCGGLAEIDRDRVTVLVNDVEELTDIGLSEATQELEKATLAVENAKTSKERLDASVELKKATARLEAVNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3I6</accession>
    <name>B5Y3I6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185846.1">
        <property type="nucleotide sequence ID" value="XM_002185810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3I6"/>
    <dbReference type="PaxDb" id="2850-Phatr46703"/>
    <dbReference type="GeneID" id="7204615"/>
    <dbReference type="KEGG" id="pti:PHATR_46703"/>
    <dbReference type="HOGENOM" id="CLU_495657_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3I6"/>
    <dbReference type="OrthoDB" id="54884at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="352"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="592" mass="65125" checksum="9A1888BE1D1A80EC" modified="2008-11-25" version="1">MYVSIHPSIHPHPHKPIHVHVHELWFHRPRPFPKSSHIPMRPMSVPSREPFDTVGEESVHGAPQKRVEPSETISVCDDDDDGDWQRSLSNPALSQTGAPATTHNDTPSVVWNTESLSIQTFPSEAHVCSERKWKTPLYNFHWNRVVSWDELEDRLAVLVGNDATVLQLLHSVYSVDVPDQVLRSLAVVALQIPDHDDPFESDTVPTSTTSTTTPWLDSSNALATVAHYLVQQHFDKRATRTRNGNQATECVASLACLRFLVTVRSPTEAGWQREEFRLAETLAFLTQRECCVAPEKDATLSKHCPTEEIYHSETTLLWELRALCLHELERLQEQALICQAWIDATAETTANCIETGAHVIKLGLTHSTTLVTTGIDAMGDVVQSCIDPVLREAGTNTEYDPRSTAAALTYTGAARRVTRQARECTQRTTSEVQDASCRAIQMAATQFYRHQVGHAVVPDDSRRHALAAAGKVGLAGLGAVVIVGEAVLESSNAVAQATVDATAGVVEHRYGAAAGQVVRNTSETAVNVFRTVGHVAMVKSKILGKAVVKKSAKTHMENQKPTTKVHAQRKQNISKVDRVTVPKEVDNSEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3K9</accession>
    <name>B5Y3K9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_46724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185677.1">
        <property type="nucleotide sequence ID" value="XM_002185641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3K9"/>
    <dbReference type="PaxDb" id="2850-Phatr46724"/>
    <dbReference type="GeneID" id="7204506"/>
    <dbReference type="KEGG" id="pti:PHATR_46724"/>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="B5Y3K9"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="279" mass="30449" checksum="87947BAF02D1204B" modified="2008-11-25" version="1" fragment="single">MATTTEYADNSEETCWSLARSSGTILAASLVLLVTTLLEASVAEGSPLEHLGRRPMGRDLGSWLLHYVTQNVGVQGYDPVLGAFSPPLRLRVHLAAVAFLWAMLLYVWPVFGIPDVCGPWRLTISVWQAALVTIATYRFGLYVIHTVMPGVSDPGGPRPHKIQRQPVWKDCLHHLPSETTWTYLTAQDSHRRSAERFAGTGAALTGEPSGRDVWSEQPLSKSQVGANTKNRIDESAVQGMAWGGRQPGFNPAVNPNSCDAPHRAQLIREYIASGKSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3N6</accession>
    <name>B5Y3N6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_52110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185689.1">
        <property type="nucleotide sequence ID" value="XM_002185653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3N6"/>
    <dbReference type="STRING" id="556484.B5Y3N6"/>
    <dbReference type="PaxDb" id="2850-Phatr52110"/>
    <dbReference type="GeneID" id="7204641"/>
    <dbReference type="KEGG" id="pti:PHATR_52110"/>
    <dbReference type="eggNOG" id="KOG1403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_8_0_1"/>
    <dbReference type="InParanoid" id="B5Y3N6"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="427" mass="46086" checksum="B334068CA85B347F" modified="2008-11-25" version="1" fragment="single">GKGARLTDSNGVSYLDTRNNVAHVGHCHPTVVQAVQTQVAKLNTNSRYLHPIMTVLASRLAELLPDPLEVVFFCNSGSEANDLALRLAKAYSYGHSNNTIVVGGAYHGHTLGTLEISPYKYEHGTEFALQDSPVNQIPCPDTYRGRHRNPATAADDYAEYVQEACQYFKRKNESVRAFIIEGGMSVAGVILPPTGYLSACVKAVREAGGIYIADEVQTGFGRLGTSLWAFQHQQHDNHGLETVIPDIVTVGKPFGNGMPLAALITSRKVADAFDACGVEYFNTFGGNPVCAAAGMAVLDVMDSEQLQAHALNVGFYLREGLVKLRERIHLIGDIRGSGLFIGVELVLDQATLEPATLQTSFVCSVLKTKYHILTSIDGPHNNVLVIKPPLCFSEQDADFLLESLAQAATVDLASGSDSNALRKQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3W0</accession>
    <name>B5Y3W0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_46819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185908.1">
        <property type="nucleotide sequence ID" value="XM_002185872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3W0"/>
    <dbReference type="PaxDb" id="2850-Phatr46819"/>
    <dbReference type="GeneID" id="7204677"/>
    <dbReference type="KEGG" id="pti:PHATR_46819"/>
    <dbReference type="HOGENOM" id="CLU_1463973_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3W0"/>
    <dbReference type="OrthoDB" id="44123at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="22432" checksum="93D526A4F1760930" modified="2008-11-25" version="1">MDVAMDEETKSNLLMLLSSLCCKLIPEKYDYGSPSLAGNTEDMTDSDEADPHRIHREGSLYNVNPSNMWMSARQLRSKPSMILLDDYEKVPTELSDNMKFVTDPTLDTGEPGLLYYSEDAFYDQNHSPEYALTLNEDIYQRLFNEIFTAKQVPCGLYFCCHGGDGAHTGVSHDDYVDIRVAWSIMSVVLVAMACIEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y412</accession>
    <name>B5Y412_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_46865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185759.1">
        <property type="nucleotide sequence ID" value="XM_002185723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y412"/>
    <dbReference type="STRING" id="556484.B5Y412"/>
    <dbReference type="PaxDb" id="2850-Phatr46865"/>
    <dbReference type="GeneID" id="7204423"/>
    <dbReference type="KEGG" id="pti:PHATR_46865"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800400_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y412"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="162"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="42970" checksum="EC7C5B1966236C64" modified="2008-11-25" version="1">MAIWVHPWIATTTVLCSSSVSSKSARFFLKSDRLALMSMKRRSISPRMAASSASNAVNKLAFLDDLLTESKMVNFTASPGSTGNVLQHNSATSTKAGWCLRQGLLHICTVDEGYAAPLVALHGLPAFYSCVTEATNGACRHDATQDIKDPSTCFESLCRIIAGQFVSGKSAQAVWKRLLEHARHDLTPTRILQLVSQPQGEDIEFGLQKPVGLTKNKAKSIVDLARHFEDGRLSEGFLTSSTSPSGDTDSTITSIQKALLKVQGIGPWSVDMFLLFYLEQPNVLPLGDLGVRKGIAIHFAMRGSVKKGKQAQLCPKQDAPQIRRRLEAYAPYQSLLTYYMWRAADTPSAPDSAATLEGKAKSETNHVPATSIPTEMSATPSRKRKRSSFRTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y427</accession>
    <name>B5Y427_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_5396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185933.1">
        <property type="nucleotide sequence ID" value="XM_002185897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y427"/>
    <dbReference type="STRING" id="556484.B5Y427"/>
    <dbReference type="MEROPS" id="S49.002"/>
    <dbReference type="PaxDb" id="2850-Phatr5396"/>
    <dbReference type="GeneID" id="7204431"/>
    <dbReference type="KEGG" id="pti:PHATR_5396"/>
    <dbReference type="eggNOG" id="ENOG502RRCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333872_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y427"/>
    <dbReference type="OrthoDB" id="45421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
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    <dbReference type="InterPro" id="IPR047272">
        <property type="entry name" value="S49_SppA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987">
        <property type="entry name" value="PEPTIDASE S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987:SF4">
        <property type="entry name" value="PROTEASE SOHB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S49" evidence="5">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="165" mass="17468" checksum="B19F4FC91E9FD261" modified="2008-11-25" version="1" fragment="single">VILSVNSPGGSVASYGLASAQIERLANVVGITTTACVDRYAASGGYMIASQAHRIVAAPFASVGSVGVIMEGLNFHDLAKRYGVQPMILKAGNEKNPLTTFGSVSKQDLKHETERLEKVHDAFRQLVVRGRPELADKLDEVANGNVFLGLEAVELGLVDAVMTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4J9</accession>
    <name>B5Y4J9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_43859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186306.1">
        <property type="nucleotide sequence ID" value="XM_002186270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4J9"/>
    <dbReference type="STRING" id="556484.B5Y4J9"/>
    <dbReference type="PaxDb" id="2850-Phatr43859"/>
    <dbReference type="GeneID" id="7203977"/>
    <dbReference type="KEGG" id="pti:PHATR_43859"/>
    <dbReference type="eggNOG" id="ENOG502ST2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851164_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4J9"/>
    <dbReference type="OMA" id="RCIMNDA"/>
    <dbReference type="OrthoDB" id="48743at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="187"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="36355" checksum="6B672BE7BDBBAA25" modified="2008-11-25" version="1">MSSPSSTAAVVSSNHNKRPRETNKRRQHYTNNPQRGGPGILLTCESGREGKCRREGLEILRFYWNTQTNAPSTPSNEPKQLSLEEELIALKTKKDPNDEPFGIFDTGCKGTVFVMCTLPNCSMISPIRKPKTQEPSEASVTSEHSIDRSKKRRLDESNGMSTTCTALQEQPPWDPVQTVRNVVHDLSSAELSNAAIPGSRFVTRMIPVQATCFASLDEIGLVLDGLLDRLLPTLSSKKSHEAPLTFSVNFKRRNCTALTRDAVIKQVATQIFSRTFWTVKLREPDFTVLIEVCKTLCGMSILPSSCQTIARNFNLANLRTKRGIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4K1</accession>
    <name>B5Y4K1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_43861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186025.1">
        <property type="nucleotide sequence ID" value="XM_002185989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4K1"/>
    <dbReference type="PaxDb" id="2850-Phatr43861"/>
    <dbReference type="GeneID" id="7204162"/>
    <dbReference type="KEGG" id="pti:PHATR_43861"/>
    <dbReference type="eggNOG" id="ENOG502SND9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616066_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4K1"/>
    <dbReference type="OMA" id="RRECRNE"/>
    <dbReference type="OrthoDB" id="47367at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="445" mass="51101" checksum="0BF8E26648440D67" modified="2008-11-25" version="1">MHQATTLRLQGKRSRRAQSFNVAKTKIVIFFLSAFWLFSFVNHQSSLLSLHTPSHAEKWDPLSLASAAIVAQDPVGKGSRVPDQVDLLRAAAQTQLERHSKISIDIISVGSHARPIYQEAQERFFGPKDSVRNFFRITEEDDTEADCSSKLTTSQLEKVVTFCKSRSRVLGEEFFHLKQMATHYARVQWLNKKANAIGWLCAQKRPFDGLVKALGAYRAQGTPDYLLVLDDDSWVNIDQLEVSLPSMYPAKTPYAVAGCMLRSRVREHNFTFPYGGWGMIFSRSAIENLMKPLFCYNTTDRIEDEFLRLACWRLSENSIGEQKVFREGMSVAQLMHAYVTDQPYQQVDSWNSVGYCLHSDWVWGYFANFYHISVHANTPYFSQVLEDRLQGFNGSEIYTGRRTPANDQLRRECRNEGDDMCTKNSNICHYVTPQHMEKLAWQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y589</accession>
    <name>B5Y589_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Biotin carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186425.1">
        <property type="nucleotide sequence ID" value="XM_002186389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y589"/>
    <dbReference type="STRING" id="556484.B5Y589"/>
    <dbReference type="PaxDb" id="2850-Phatr843"/>
    <dbReference type="GeneID" id="7204016"/>
    <dbReference type="KEGG" id="pti:PHATR_843"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="InParanoid" id="B5Y589"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="119"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50920" checksum="9775B75C4B0CE7A7" modified="2008-11-25" version="1" fragment="single">KVLIANRGEIACRVIRTCQRLGIPTVAIYSSADGPDCLHARMADESYQIGTGPTPRESYLQPDDILRVALDTGVHAIHPGYGFLSENAAFAELVTNHRMTLVGPPPSAMTAMASKSRSKAIMEAAGVPTTPGYFDQMGLPEHQTVEFLLSQAVRIGFPVLIKAVMGGGGKGMRLVGQESEFDDALRACQREAQSAFGNADVLLEKYLVRPRHVEVQIVADSHGNVVHLFERDCSLQRRHQKIIEEAPASDLPPDLRARLGENGCQAARAVGYVNAGTVEFLLDTTTPGDFFFCEMNTRLQVEHPITEQITGVDLVEWQLRIAAGEVLPKTQDELYARGHAFEARVYAEHPARGFLPATGTVWHHQPPAPVNQGSCKESGIRVDTGLQAGQQVGVYYDPMISKLIVHDTDRTAALQKLVRALKGYQIAGVPTNIDFLIKCATHPTFGKAGAVNTGFLEDFADDVRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5B5</accession>
    <name>B5Y5B5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186157.1">
        <property type="nucleotide sequence ID" value="XM_002186121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5B5"/>
    <dbReference type="PaxDb" id="2850-Phatr44092"/>
    <dbReference type="GeneID" id="7203862"/>
    <dbReference type="KEGG" id="pti:PHATR_44092"/>
    <dbReference type="HOGENOM" id="CLU_1121924_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5B5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28432" checksum="B129318EEC57B838" modified="2008-11-25" version="1">MATEMLQNENLMKDPTHKEHEKKEFEYEIFQGKLLTEGTGTSLPADTQLCVMHTKAFPLAEDEVLEVMDTHGKPYADGIHFKAHRTLFGKTSIVLHDKSHEPIAMCQQMLLAPTPAYTIYGRKPLLDGYTGGMIQAEKVRFFPWYQVSEVDLSNRRVLIMKWNGLCFMPFLSATGNDCQHTIEDGRGFGILVGRIEKKNEFLPHDETVRFQWNISFHPEADPAMMLCIAAVLDNFFYRAHIQRKVDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5B8</accession>
    <name>B5Y5B8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATR_44096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186440.1">
        <property type="nucleotide sequence ID" value="XM_002186404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5B8"/>
    <dbReference type="STRING" id="556484.B5Y5B8"/>
    <dbReference type="PaxDb" id="2850-Phatr44096"/>
    <dbReference type="GeneID" id="7204030"/>
    <dbReference type="KEGG" id="pti:PHATR_44096"/>
    <dbReference type="eggNOG" id="ENOG502QTIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498287_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5B8"/>
    <dbReference type="OMA" id="YFATCIP"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054170">
        <property type="entry name" value="RlmL_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313:SF1">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22020">
        <property type="entry name" value="RlmL_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838398" description="THUMP domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="6">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACI65910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="547" mass="60719" checksum="774F58F6DA18E2E0" modified="2008-11-25" version="1">MTRTHPARLLLLLSVFLWKSCSCVFALSTHRRLACSRPSSPRAAAAYRNHLDDESLDIGSYIATCIPGLSDALSDELRTLGCQDVERSASSAVRFNANTQTALKALLWTRTSHKVMEFLCESPPTLKSREDLHRFILDAVPVKELLGDGRGGLLTLSVGVILNNPSKIPKDINHSHYSALTVKNALCDAVRELRDDRPNVDLDDPDVPLTAVLLGTDSGARVSLYRQLHNGSLHKRGYRSGAIHKAAMKESLAAGLLLTAGWDQKCRDARREDDAVVLLDPMAGSGSLLLEGAMMAVDLAPGLMRIKCGLPGHSMPPVVRWKHDGDMRVVDEWKALLLDATSRAKSGLRWMQSTDTVEILGNDIHDGALNLFENALDAAGLRRLVQLEEGDCSDWKPKPKREGTPFIVVSNPPWGVRLTEDMSESWESMRIFLRECCPSGTEAWVLSGNAEATKHLGLRRSQSLALKTGDQDLRWLQYILRDRSEILAEIEEKKSRRKDLNPYASKPAKRIQDTGRKNSSVPSKAKENFKQAERRRQAAIGNEWMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5L7</accession>
    <name>B5Y5L7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_44182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186490.1">
        <property type="nucleotide sequence ID" value="XM_002186454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5L7"/>
    <dbReference type="STRING" id="556484.B5Y5L7"/>
    <dbReference type="PaxDb" id="2850-Phatr44182"/>
    <dbReference type="GeneID" id="7204101"/>
    <dbReference type="KEGG" id="pti:PHATR_44182"/>
    <dbReference type="eggNOG" id="ENOG502QUQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y5L7"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68585" checksum="34D3E14F25DCF4B0" modified="2008-11-25" version="1">MRMNKFPTHLELLTSVSVEISAFRGNTYLYILFPYFLSNRMFPARVRTRPKPGCFPRKRGQLEGGVPESGGRSLSFDRNGMCRRADEQTNRATTRQAQPSRDRPELWYTQTVNQHRKRVSPKDCFETVPETKSTPTCILGILGGPWHDSVRLGAYATRDPAHPPPPQKTGKISMPARRRPSKKASSCLDNYNDDQQRRMAARPDGSHRRWNKRNIAYGAALIATLLIVAVVLLAVLLPDTNHDSNTGSTTTTTTTTTNDASTAAPRWLPNIFGADAAIQCPILSGDGGTFVLRALHNDPHCQPLAATVARNKHSTGNYRVHNQQTRTMYSLLVFLSFLFAYTCIQTKPPPRRNITTMGTFELLETVPHDANAFTQGLQSVPDDRTTTASTTSTTSKMYESTGLYGASDVRIVDVATGGVLLKTELQSQFFGEGLTYYVDSLAQEGRLVQLTWKEQTGFVYDPTTLVQLSNFTYKTSNTEGWGITYRADQNIFYVTDGSTFVHTWNVEFQEIAKVPVTMQNTATSNPSTLNLINELEWDVNSRTLLANVWMQDVLIRIQPETGFVTTVYDLTTLFLNRPNSADVLNGIALTDVPDELWVTGKLWPNMYRIRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5W4</accession>
    <name>B5Y5W4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATR_4234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186260.1">
        <property type="nucleotide sequence ID" value="XM_002186224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5W4"/>
    <dbReference type="PaxDb" id="2850-Phatr4234"/>
    <dbReference type="GeneID" id="7204152"/>
    <dbReference type="KEGG" id="pti:PHATR_4234"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046494_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5W4"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACI65730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="286" mass="30427" checksum="A54C784C91E711FE" modified="2008-11-25" version="1" fragment="single">SSPSLDRSALIYMLLLAVQFGLQPILTRRFTPPDITRSTVVLIQELVKGLLALSMMQITGSTKSALNGWSVRTWISVAAVPAVLYAIQNMAALVAYQNLDALTFNVLNQTKTLSAALCCYFVMGRKQSLTQILALLLLLLSALIMEGIVGNDPGEDNFASATAWDAKHYTHGVAPILLASFISGLAGALSQSNLQSTAGGGRNPYLFSLELCVASILVLTASLAISTDGQHVLREGFWQGWTLPTFIPIVVNSVGGILVGLVTKYAGSVRKGFALIFGILVSGLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNV4</accession>
    <name>B7FNV4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_31617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176602.1">
        <property type="nucleotide sequence ID" value="XM_002176566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNV4"/>
    <dbReference type="PaxDb" id="2850-Phatr31617"/>
    <dbReference type="GeneID" id="7195965"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31617"/>
    <dbReference type="eggNOG" id="ENOG502SDXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1513422_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNV4"/>
    <dbReference type="OrthoDB" id="41475at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19528" checksum="6EFD31B0D299EEDF" modified="2009-02-10" version="1">MRSSPSTTLSPMNPPQVSYSDLSPFGRVVAGTVEICFSTLLEYFSGFMGGYFLGTLTGIPRLVATPIQPEIQQTFFRELSARTVRMHGKSFGWAKQWGGISAAFGGFRVATKVIRGGVEDEWNTIMSSMAAGAYFARKEGPTAMIRGAVVYGGFMYLLSGGLFAKKEPFQYEERPIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNX9</accession>
    <name>B7FNX9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_42614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177117.1">
        <property type="nucleotide sequence ID" value="XM_002177081.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FNX9"/>
    <dbReference type="PaxDb" id="2850-Phatr42614"/>
    <dbReference type="GeneID" id="7195978"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42614"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247416_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNX9"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1458"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
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            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="667"/>
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            <end position="680"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
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            <end position="1310"/>
        </location>
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            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1528" mass="170321" checksum="A0CB561706D766EE" modified="2009-02-10" version="1">MEDSPVSQHHGCHPRRDPGGINPDGCGHKSGEDPLGVGPSVLSPCPSSQGGELMGSPPTPTHRNTTPTALTAMLMGVPPPPPSDPPPLRTKRGSTPSRLRQDEVLSALNKRSSSCTSGEIILSSFPGQASIVTTATVEDTAMTAYTDKPRSESTIATSPSKLGLIQQRLQAARAIYQSDPLILNPPEGNDHIGRYSASLIPATESSGQISYSTTSATPVGTQIRPLSPTRSLSIPTANSSIEAAPVTVRAFSLSSTSQEDQSTNTKSPKIYRPSTPDARHRSKILERCHQKDYEAKHNGRLLAGQQKRKGFFRKFFGKKGRSGTSVEEENGTFASEAIVSHSTIDGLEYQQTVAFPEPSIRKSMQEAIKPPNGSKDTVQTPHEDQTVFIDNDRPELFFGHDDVSLLTSPTWNSKNRKSEDPVQEVGHEKLSDPMGYYWKKPMENQSTQELNNGSLAIDPFSAPFFHEPAGRSPVTNQTEFLQGKVHVKVNDADGPGDDPQTQQNGSYMATSPIPSLQDPSSFSLNTTDFSEYQFHDPLGESPLQHKHHLSPAPRVDSVSSSDPTVHRNPLSMDHESDEEKKDEENHSSYTDNAANVFPPPPPPLPETATQSKSQGKQRPSAHPKLILKENGNSFKPREYWSKKQTLTMKSSPLATSTSHASVSGSTLHDSDTGKVVDTPDHFSSAKSAPASRTTANELSPSWTVSSVARINAKTVAYIHTLNGDPSPRRTWRKSDAQALDVARMKKQRNTNETANLSLIAKPPGMCVELHKSPNFAETCAISYIANRKTDEPSYAEDIIGSKSVSLGFAIMRERREASIACGASQRVVLVKKNAVPVVDSYFSSFDDPEPRDPIQRAGRRLLAKAAIPIQAHARSFLAQRKAVDRMWALIEIQSYARRWKAEASLLGNRTSATRIASRFRGYKSRVELNKLNDGAIQIQRIVRGYFAAARTYDAVFCIILVQARARGNNVRQKTIQSSKSAIKIQSLVRGFTVRCNFALWRDQRLFTLSQRLQATIKIQAIWRGFQGYTDYIFALVDVLVVQRTVRRWLAQRKACEIRKHRAAVILQSDWRRFSSQMALLYSFVRIIIVQSLARRFLARNALQNKQIEIEAEIAAAIKIQAFWRGFWSFSHFVIIQYESIRLQAIARGSMMRKRLKLQLGCCIMIQAAIRRRLAIKRANNLKMTSLFHAAALISMTETVACQHMQFWWRVVLDCRKEKKAALIIERFFFMVKEEVEKEIRRVKAKKTLRKENRRHRTKDDDENLLERVWLSTVDEDRVGVFAYARNDPIRSDGLAKSPSNKSINRSNRSRLNTVRHRASSPTMNLIMRHDQESKRRYSDPVNRSLADNTSEISGATAVSFGFKRAQMRKTGFPNDKDHHREDLSMVQPQAGTGTRQGKQKENSVEKYLQMYGIKTAPNRSSRVSSFFSDELESAIPNSCKESGFNAKKCRKSTSSIPAGAAGTLYQDRNRPTAPLDRDSCQTNRAYPTAAASPRHGRIQFLHPHPVYAKGKTVDDISMEFVGEEFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP57</accession>
    <name>B7FP57_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin o</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Trx-o</name>
        <name evidence="3" type="ORF">PHATRDRAFT_31720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177158.1">
        <property type="nucleotide sequence ID" value="XM_002177122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP57"/>
    <dbReference type="STRING" id="556484.B7FP57"/>
    <dbReference type="PaxDb" id="2850-Phatr9164"/>
    <dbReference type="GeneID" id="7196019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31720"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_1_1"/>
    <dbReference type="InParanoid" id="B7FP57"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="133" mass="14745" checksum="ECF0856B323B72F2" modified="2009-02-10" version="1">MSTTIAMIALRPSFRRVTALTGVTRRSMSVITLSDQEAVEKFKTINSKTVCYFTAVWCPPCKQIKPIYEEMSTKYDGVAFGKIDVDDNADAAVEYEISNVPTFIAFDGEEIVARFSGADPNQLTSMVEALKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPF0</accession>
    <name>B7FPF0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176703.1">
        <property type="nucleotide sequence ID" value="XM_002176667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPF0"/>
    <dbReference type="STRING" id="556484.B7FPF0"/>
    <dbReference type="PaxDb" id="2850-Phatr42755"/>
    <dbReference type="GeneID" id="7196383"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42755"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682348_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPF0"/>
    <dbReference type="OrthoDB" id="46759at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="391" mass="42184" checksum="5F7BD5A5DB7520BF" modified="2009-02-10" version="1">MFARFLAEEHLDEDHHDEEHHDDDKPWGDTRILPAFAAGALLAAAVFLMIPESLELLGGGHEDHEEESTSEFLNSTVEDDHNSTSDADHSHFRRFLEAEGELSSHGAGPTWKFGASLLAGLLMPILLTAIFPVPDIEDCDVCEKLQENEDSALSPAAAETVREQNEEANSDKANTEDKTTMDDGCDAGACGHPSHVNKADDGTDDSEVSVNKLDKSKSALPLQGHAINWGLASSILLGDAFHNFCDGLFIGNAFLLCSREVAYTIVATTIYHEFAQELADFALLVHHCGLGRVRALLLNFVSGLSVLIGALIILASDLSDQATGSILAISAGVYIYIAASECIPRIQAKRKTIKDTLIFVLCFATGAVPIGLVLLNHGHCEAGHDHEEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQV3</accession>
    <name>B7FQV3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177471.1">
        <property type="nucleotide sequence ID" value="XM_002177435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQV3"/>
    <dbReference type="PaxDb" id="2850-Phatr43168"/>
    <dbReference type="GeneID" id="7196919"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43168"/>
    <dbReference type="eggNOG" id="ENOG502TAWA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074949_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQV3"/>
    <dbReference type="OMA" id="HYNQTET"/>
    <dbReference type="OrthoDB" id="424053at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="31721" checksum="71BEAF4653F7AA0A" modified="2009-02-10" version="1">MNFERYPWLKDLTTADALREIAKARRQYQSQGAFLFPYFIRPDVLEKCCSEARAQESEAFTTDDHHTAYLGPQNCNYPENSVVNHKMKTQVASIAYDELPHESSLASLYNDETLLRLISLIVQKELFLSDDPLGCCSINVFRPGYHHSFHFDESEFSTTLMLQDAADTDSGLFQYTDPLRQSASDPALADVAAIVQAYDHMNEPPHGGFHEHDAAHRAPTLHTLDFRPGTLSLFSGSRSLHRVTQVRGSRSRLVAVLTLATQPGFRNSVVVQKLFWGRSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR47</accession>
    <name>B7FR47_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_8694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176981.1">
        <property type="nucleotide sequence ID" value="XM_002176945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR47"/>
    <dbReference type="FunCoup" id="B7FR47">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FR47"/>
    <dbReference type="PaxDb" id="2850-Phatr8694"/>
    <dbReference type="GeneID" id="7196965"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8694"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_3_0_1"/>
    <dbReference type="InParanoid" id="B7FR47"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="63" mass="7474" checksum="3D04F26474E028FF" modified="2009-02-10" version="1" fragment="single">MSIYEEVEIEDMIFDEDELVYTYPCPCGDKFRITLEELWEGEDVAKCPSCTLRIMVIFEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRD7</accession>
    <name>B7FRD7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC50992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176529.1">
        <property type="nucleotide sequence ID" value="XM_002176493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRD7"/>
    <dbReference type="PaxDb" id="2850-Phatr42459"/>
    <dbReference type="GeneID" id="7196033"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42459"/>
    <dbReference type="HOGENOM" id="CLU_467335_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRD7"/>
    <dbReference type="OrthoDB" id="57480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854917" evidence="2">
        <location>
            <begin position="24"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="557" mass="60397" checksum="BF6165BD4BD1694D" modified="2009-02-10" version="1">MKSIKGSVILFAAFIAAPLIAAGIDISSDESILSEFSTNPIGIRGLANRIKRTPVMQRTPKTKALSRRSDSKNNKRSNIKINRKPEPANAMDETTPNQDTTCALEPTVVDSTIIVEFSGNTGEPLPETERAALQNAVLTSYNELLASGCDFPFFREAVAVTILNESGGGANITAPARALKEDSHFSISNRRDLRRLFKRRFTFGVTVRCRGGCPPETTAFTGNKSGNTTAPNPKASKTAAPTSAPKQTSPNTQCRCTIGIVIPPAETDFTEVFIENVADLQESRELPAELGLPDATIELEQQSCEEESIFESFVTIDVNGDPSNFTSVEIDLMEEIFIQSYNDLNADNCDPNFLRIRNASFVLPDDLPELPGGGTRTLAIQHRRERFLRKIGFRFTASCFDCRGESSVFTGNIGSRYLEESTSLVVDTRRGLQVNVLEDCFCPAFGVVINRPPTVEEFEVAFSETFVEVKTESVLFEDIESISNVTEDNDVILDPSHVPTTVPSLMPSTEPSLMPSVAPSSKPSSHFPSLTPSANPSKAPTFAPTPGSALPSGPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRP5</accession>
    <name>B7FRP5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_9546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176577.1">
        <property type="nucleotide sequence ID" value="XM_002176541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRP5"/>
    <dbReference type="STRING" id="556484.B7FRP5"/>
    <dbReference type="PaxDb" id="2850-Phatr9546"/>
    <dbReference type="GeneID" id="7196257"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9546"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRP5"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="191" mass="21911" checksum="D90AF7EBFE6A5081" modified="2009-02-10" version="1" fragment="single">DQVINLIDEFCYRRHWMMHVGPEKGKVLENHLAQCLDAHLLKNRAKPFLVLEVGTYCGYSSIRMCRTILSKLMDANKCFHVMSVDVNPHSQMVAKQLVALAGLEAYVTFGLLTDLESNRDELSQSIWAQVDVFSTEYGSSGLDFVFLDHDKDMYLSDIVQLERAKLIRAGSFVAADNILFFRLDDYQRHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSE2</accession>
    <name>B7FSE2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_43490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177967.1">
        <property type="nucleotide sequence ID" value="XM_002177931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSE2"/>
    <dbReference type="PaxDb" id="2850-Phatr43490"/>
    <dbReference type="GeneID" id="7197542"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43490"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_1_1"/>
    <dbReference type="InParanoid" id="B7FSE2"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="630" mass="69965" checksum="E2EEC91C42E8894C" modified="2009-02-10" version="1">MFESRTGRTRFLTVLLVSAGIGSEGFEASGRPRLRNGKLKTPRRFFVRHATIAENEAPESSHLGATPPDMVAFASGYTTVFEELVCKSCQASQGEVPDDLFGTYFRSGPAMFSAGSILPPKKSLIQPKQPPVLDGEDKTRMVPHPFEGDGAVLGVTFSREGDVTARFRFIRGTPFTYERKKGKRVYTGMDSTRMEGPSAGGGLANDLPLPLYRHNLMPGLNKLRKNTANSRAIYWGKRLFSLWEGGQPHKLDALALSTDGRSMLGGAIKKEADPFGGKMIYDPSKNRALFYAVSHESKDSSIVCYEFDDKFRLIENGRIETTVPGFALITDFAATENYAVFVQPPIATNGMKFLMDKGPGRALKVEDRPSIVHLIPRPESSKQQMSLPLPIDSLSDSNLHFINAYEDGDKVLSWPWGSSLEEYQACASKKSLWRYTIDTQRGSVSKKLMFNDHCFFGGINPAVSMKEHRYIYMNVGALGADVAPPQGIARFDCETAESQVWMPENFEFCGEPMYARRATEDGSNDPGYILSVLYNGKKNESELLILQANKIPSGPIARLPLDIAIPHGLFGCFSTAEEATSWSTEEIERRAKLADKMESKGNMWNEVRSEFSGLGLRFSDMDEYGFDFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT68</accession>
    <name>B7FT68_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_4025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177788.1">
        <property type="nucleotide sequence ID" value="XM_002177752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT68"/>
    <dbReference type="STRING" id="556484.B7FT68"/>
    <dbReference type="PaxDb" id="2850-Phatr4025"/>
    <dbReference type="GeneID" id="7197244"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_4025"/>
    <dbReference type="eggNOG" id="ENOG502QPSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067216_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT68"/>
    <dbReference type="OrthoDB" id="10259487at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011859">
        <property type="entry name" value="Dihydrodipicolinate_Rdtase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02130">
        <property type="entry name" value="dapB_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836:SF0">
        <property type="entry name" value="4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="DIHYDRODIPICOLINATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydrodipicolinate reductase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydrodipicolinate reductase C-terminal" evidence="13">
        <location>
            <begin position="136"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC50602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="278" mass="29735" checksum="EB37B356261CC0F6" modified="2009-02-10" version="1" fragment="single">VMVNGMPGPMATAAAEACLRKGLQLAPVAMTGPDVEASTFIVTDTVTGTSSSVRLVPSSDTEELVSAVAGMQTASERLLAIDYTHPSAVNGNAKFYVEQNIPFVMGTTGGDRDELMKDVEGHFCVIAPNMGKQIVAMQAALEDLANKYPSAFEGYQLEVVESHQKTKADTSGTAKAVISSIKTLAGDEKYSNDDIKMIRDEKEALAFGVPEDAMMGHAFHTYTLTSPDGSVSFQLQHNVAGRTVYAEGTADAVKFLAKKMKTEKIPRVFNMINVLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT74</accession>
    <name>B7FT74_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_43713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178106.1">
        <property type="nucleotide sequence ID" value="XM_002178070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT74"/>
    <dbReference type="STRING" id="556484.B7FT74"/>
    <dbReference type="PaxDb" id="2850-Phatr43713"/>
    <dbReference type="GeneID" id="7197008"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43713"/>
    <dbReference type="eggNOG" id="KOG0310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414783_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT74"/>
    <dbReference type="OMA" id="ATYQVVH"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="460"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC50920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="609" mass="66800" checksum="B3080F914E58852E" modified="2009-02-10" version="1">MTTVITTARTTTNEFKPSIELQSKKPTTKSITSALPGAVSDSSEARYWSNKFGLGDASGSIPQFAHPRKLLLKAGSAAMVHKVLFGPAAFTSFNPLAVVSGPRVRLYGTTQQSTFHRQLTRHSRRVANDIVADRQVQTGGHLALTAAYRHDGRLMAVGLENGQVRIADATSRATLCTFESTTTAKLPMRVLQWFRDGQHLLSAGDDGVVRVWQLSQGALGARNALLELTGHGDAIRCAELWQMPAKESQGSWPNRALAFTGSYDHTIRIWSMDDIVSAKQQEDSKEIPQEDRCLSVLSHGAPVEAILLMPSTDPNVPVWLLSVGGTAVKVWNPLTGLCVSTTLAQHRKTITSLIAAPRENSETGETYVRIVTAGLDGLFRVHTWDSQTGQIAHLHGIKLPMSITCLAMNEAADRLAIGTIEGTVLVRQKGPSLTQHKRQREPKAGTYSFFTRGMNADVVEGDYVVEATSKKRKLRNFDIALKEFRYGDALDEALKTRIPQVVVAVLEELGKRRGLTIALSNRDEESLEPLLSFTVRYVARPRFSALLVGVANKLIDIYSNVSGQSEVIDELFDKLTTQVSGECRAQKMLLRVMGQLDAIMSTAERDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT89</accession>
    <name>B7FT89_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178114.1">
        <property type="nucleotide sequence ID" value="XM_002178078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT89"/>
    <dbReference type="PaxDb" id="2850-Phatr43727"/>
    <dbReference type="GeneID" id="7197254"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43727"/>
    <dbReference type="eggNOG" id="ENOG502TACX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884176_0_0_1"/>
    <dbReference type="InParanoid" id="B7FT89"/>
    <dbReference type="OrthoDB" id="761598at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006747">
        <property type="entry name" value="DUF599"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31168:SF1">
        <property type="entry name" value="DUF599 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31168">
        <property type="entry name" value="OS02G0292800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04654">
        <property type="entry name" value="DUF599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852605" evidence="2">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="315" mass="34836" checksum="A774D4148965B20C" modified="2009-02-10" version="1">MMRATAALVLTFSATCFGAHVAIAGFHQPLHVVPRNRKPIVSSRQAVRLHSSVRSVASPPAPPLNVLERFTKSVNTGAETVSNYVEVGWNKAVSRAAVIGGSTVHQLAHPWVVPTVTAMLAFGVLASYHYKLYKQETSGVSTWRSTQANTRVEWAKHVRDTENWIYATQTLRNAITANAFLATTVLSLLTVITGKIVPMIKDGVGRRTITLQFVFVSFSMLLSAYEFLQSARLMTHAGFMFPVTKNSTKVDSIMRKSQNGQWLGLRWLYLSLGFLSWLVGGGMVFLLSALLLTSFFRQIDRVPSIIDEDTVHVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUF5</accession>
    <name>B7FUF5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_44535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178585.1">
        <property type="nucleotide sequence ID" value="XM_002178549.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUF5"/>
    <dbReference type="PaxDb" id="2850-Phatr44535"/>
    <dbReference type="GeneID" id="7198068"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44535"/>
    <dbReference type="eggNOG" id="KOG1419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283495_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUF5"/>
    <dbReference type="OMA" id="MWITLLN"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="897"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="52"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="404"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="681"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143154" checksum="58F2170FD9BDBB45" modified="2009-02-10" version="1">MPFVNDLEMPPTVSTEFTPLLRHESETEEGEAAPTSRERLYLFLEAKTPAGRWYERFIFALILLNVASFILASLFVEDYNDAPWASRKHGLCGNLCDALWFGNYRDNGLEWLQLGSTSVLEIGTVLVFSVEYVLRLYTADLEDARYTGLAGRLRYVPTFFSMVDLASTVPFYVDIFLRHTDLAASSFLRMFRLFRMMRVEGRYDTALTMVDDVFAAQKAILGTALFVGFTTWMTVSSLYYLVERRSNDMIYCGAAPEYCPGDLDTNLCVIDDWGVTNCTAAGCPATEEYPEPCYNLFNSIPMASYYALLNLFGEFPLIDQHSSAGQVIGTLTAVVAVAVFALPAGIIGNGFEDVIEKRRDTSDEPSEIVEEGGMTSGHQSPNATPRGWWYNLLHAQTIPGAAALDRFINSLIVLTALSFMLDTISTLSSKTHILLDSFELISVTVFTLEFAMRVYAAKEDPKYNHPGGRFAYMMTFLALVDILSFLPFWFEVIFTGKIITPYSDSSSTWSNVVKGLRLLRILRFERYTHAFTSFDDVLARNKDVLAVTAFTAILFWVFFGAFLYFTERDNPDEEMASNYNTVPNAMWITLLNLAGESPLSQYSMAGKVATGVLGLFATGVFGIPIGVLGAGFEEVVEQENEDNTEELEFQDHSTRSTENLGISVEQAAYNFVNGNGSTAAQYFEKMIYVLIFLAVAVGVWQTLEGQENTFSEVEWGAVIIFTAEYLIRLIGAGADPDFAKGCGVVQSRLRFLISFYSIIDLLAIIPFYVAFALPNSIVNDYDEYLRMLRILRLIKLDKYVPSITLIDDVIRLKFNSLRVAFFAAITLWILFAALLFLCEHKDGWNSIDNVPLYGCDENCSMVDRFQNFFDSMVYTGIHLTGDYPIITYSWPARFVNFFMVIAAVGVVSIPSGLIASGFVQIVQSKNKVQRGEDPISPGGRAGDDWYEIHYRTLEGVDPPPSPLGPKVDEWQHAVNKFLNGTKISGSHTQWTRVSYASRVFIFAVIISNVLAVLVESIPRIDKAVGNQAGNFFDVFEAFSVMIFASEYILRLFCAPKNREALYSTFIYATTFFGIVDLLSTAPWFVQEALIATGRLNAGGDSAKIFRLFRIFRILQLEDFITAFSKLDNVFRASKDVLKATGLMALIIWVGCGALFFIFEENNPNWRVCDASIPLSTPDPNQPGCYDFGSTAACNQIYPGLCTQKAFTDMPNALYYTAVFLGGEWGVVDFTWPGRMVCLFLCVIGIGLYAIPIGSLFDSFGAVLGMGGDDDEEEERAEEGPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUN5</accession>
    <name>B7FUN5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178351.1">
        <property type="nucleotide sequence ID" value="XM_002178315.1"/>
    </dbReference>
    <dbReference type="SMR" id="B7FUN5"/>
    <dbReference type="STRING" id="556484.B7FUN5"/>
    <dbReference type="PaxDb" id="2850-Phatr44609"/>
    <dbReference type="GeneID" id="7198105"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44609"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246815_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUN5"/>
    <dbReference type="OrthoDB" id="48144at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1508"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1541" mass="172599" checksum="08AAF15532E299BE" modified="2009-02-10" version="1">MPSEPEKEWTLEHHLVGSTLPRSVPIRVSGQHYAITEQNTTLQFFQPEDIPARKPALWRSITTGWEEHGVALALDNVASDMQDPVVLDISHNQRVLTDRIQSILLKEVLDEYLPDLIMVAALEEVTAQFLKQRMLEENETAITQSSASSKSNLPMSPPRYYSKPPSSYLTPPVFNDPAGKESSELPVAVQFTPNQLVARIKQGCAMVYALEQANNPPPSSINTSAMSERRSSSRIARKETQKVQDETDRTALWKIVPGGKVATFLHNRLYQKSVPASERTKSEVLDSTTYDERGKEKSSELMKQEPTEESNQAQIKSDDVVKILPKEITKVDEHQNSLNTLQLHAELPLLGAMRVDVDQKNDHAEDEEISEPADETYSPEADAEGDADEEDETGSYTKENLEDLQLENVHNAKDRREVTVDKNGDGEEETDGEGIEVIDAKNPYLQPTNSFVLEWLGRKTGKYLSNEDLQNSFPQLIVTASKKKKMKASQNEMGRMLQTLVTPLDRLVWRYTMASEIGMDNPEARLALETVVEEDPPDVMKWETSYFGRTQFTLRVLHNSVAEEVKVREANGLVEAEAEYKAKKTWDSHRYKGIHGGHTCWPSWTDGVANWYEEQKMHRKDEDKNDAQINKTSIKENTNDILLAQSIADLETEGRGSSRRAKRRGVEGGGVFYGTQSNMTQKQLMDTLLRLVSQNSFQTAASLLSAVPEESSDPMRRIRTALGRVLWKRNQVARISVKTAWTDLSIWKTLQSGPLLSIADSAYSNNANVSTCSLETNLTSSDFELIEYVRRLHQIELGLRSLVIKHLTEIPLAIIATAADERPGTMEAMDDADFEGSGGVQWQSTGHSFLTKRIFRPSETQNTNDLTPCYWFTVHDFAPSIASGPEDEQAPSSERAVIGNAKDCNTVERRMRFRASLESSGPNGDLPAMNLLLTEAQVLAGLKAAEIESNQKGAALLRENPFSNEIGAKITLLSSNNQEEACSFNAAIAGHNSIVGANGQMLHTVLMLPDKGSSRQEAFWATLEASSRGMWSCKITGDPYTYFIQQFDYHSGSAAFEECRAIVNYIRRHPKTAAFQEPVDPVALGVPEYFSVVKKPMDISTLSNNLEEGKYSNIPPATAIGRTPVARMLNGPFRKDVERIFNNAMLFNPPDDWIHQSAATAKKAALKKIEQATKVAEEKAAGTSRQKKSIYIDYDSDVDMYVDESDQDEDFGGLRKSRKRKAVSRPKAKEDASSRAVEAPIRLQKMVSESLGLRGPLANLPISTDPLTFSLPADWTCKSGAVVTVTDAGIVETEERELSEELGELITLHKQTEAAEVLNLRRSTRGHLYEEDEQNGTREMNLTQFEYLTRSSWFNIDDGASLGPLRNRLEVELSCERLHEEYFAREYDKRRKQIVSTAEDGNRFGHYTEGSFPPYLGHLVPMRSPDSDTEMLWEIRPAYIAPALRWVIRGLVNSQHLAALEPLTTDSMNSGVVLANHIYYLDPSTKACEVLNLKEIQRRKRADHGGDQEESEDEIELSEYDKLRAERVARNADRLKALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUR4</accession>
    <name>B7FUR4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase B</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
            <ecNumber evidence="7">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PHATRDRAFT_26290</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EC" id="4.2.1.99" evidence="7"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178642.1">
        <property type="nucleotide sequence ID" value="XM_002178606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUR4"/>
    <dbReference type="STRING" id="556484.B7FUR4"/>
    <dbReference type="PaxDb" id="2850-Phatr26290"/>
    <dbReference type="GeneID" id="7198120"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26290"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016536_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUR4"/>
    <dbReference type="OMA" id="PLHAKAM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01581">
        <property type="entry name" value="AcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01576">
        <property type="entry name" value="AcnB_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000008">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.310">
        <property type="entry name" value="Aconitate B, HEAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004406">
        <property type="entry name" value="Aconitase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015933">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036288">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015929">
        <property type="entry name" value="Aconitase_B_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00117">
        <property type="entry name" value="acnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006690">
        <property type="entry name" value="PRK09238.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF4">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06434">
        <property type="entry name" value="Aconitase_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11791">
        <property type="entry name" value="Aconitase_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74778">
        <property type="entry name" value="Aconitase B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase B HEAT-like" evidence="24">
        <location>
            <begin position="105"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase B swivel" evidence="23">
        <location>
            <begin position="275"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="22">
        <location>
            <begin position="584"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF06434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF11791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEC50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="989" mass="106672" checksum="83D72EA4D5E1C062" modified="2009-02-10" version="1">MSSLALARRLSSSLGHGKKSIPHSAFATLANPLVSWNGDVSRNTDASPSVSATSRNHVHALCASSSTSATVFAKNSTFTGSTWSPASVPLMRSFSTVSSTDFLQAYEAHVAERLNEADGLGIAPKPLSAEQVSDLIAVLKTETPNAEALLDLLVNRVPPGVDEAAYVKATWLSALAKQEETNPYITRARAVELLGTMQGGYNVATMVELLEDSDNEIAMIAADKLSHTLLVFDAFYDVQTMHEKGVAAATKVMESWASAEWFTKKPKVPEVMTATVFKVTGETNTDDLSPAQDAWSRPDIPLHAVAMLKNAREGINPDKEGEIGPIQQIRALQEKGFPLAYVGDVVGTGSSRKSATNSVLWYMGDDIPYVPNVKSGGLCLGSKIAPIFFNTMEDSGALPIELDVGEMNMGDVIDVYPYEGVVKNHDTGEVVTEFKLKTPVIMDEVRAGGRIPLIIGRGLTVKAREALGRDAAVTDVFRMPALPEGSKKPEGFTLAQKMVAKACGLPDGEGVVPNQYCEPRMTTVGSQDTTGPMTRDELRSLACLGFSSDLVMQSFCHTAAYPKPVDVVTHHTLPDFIRTRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFGAATGIMPLDMPESVLVRFSGTVQPGITLRDLVQAIPYTAIQMGLLTVEKKGKKNIFSGRILEIEGLPQLKCEQAFELSDASAERSAAGCTIKLDKEPIIEYLNSNVVMLKWMIAEGYGDPRTLERRIARMQEWLADPVLMEADPKAEYAAVIDINLDELKEPVLALPNDPDASALLSEVQGSHIDEVFIGSCMTNIGHFRAAGKLLNKLEKPIPTRLWIAPPTKMDEAQLVEEGYYSIFGSAGARTEMPGCSLCMGNQARVAPGCTVVSTSTRNFPNRLGQGANVYLASAELAAVAAIEGRLPTVEEYMKYMDQVKDDAADTYRYLNFDQLPDFVKKADSVEISAEMKDAAHKLSMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVU0</accession>
    <name>B7FVU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Abitram</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_34363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178991.1">
        <property type="nucleotide sequence ID" value="XM_002178955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVU0"/>
    <dbReference type="PaxDb" id="2850-Phatr34363"/>
    <dbReference type="GeneID" id="7199780"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34363"/>
    <dbReference type="eggNOG" id="ENOG502SU1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_941619_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVU0"/>
    <dbReference type="OrthoDB" id="48130at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26870" checksum="04E4F1B9B019858A" modified="2009-02-10" version="1">MYLKFTSFFPILLECTHGSSTMGKQNGRKRSHEDRDDAYKQAYAQVRFVPILSTGRPGTPHRYFAESYTVERSDSKPKDANDAYSCTDIISQVVHKHANGLVVVTAGNHLPPNTQSLQLLIQESPAAQESAATKRKQQAKMLKGKQMEGSVHPNDVIATISFLKGGQQHCVPLLSNVWGTVLEVNPSLGEPKARLPRSIAEDPLLDGYLAVVLPSGPFPPAVTLTGELLKKETDNSGECFRQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVU7</accession>
    <name>B7FVU7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_11189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178766.1">
        <property type="nucleotide sequence ID" value="XM_002178730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVU7"/>
    <dbReference type="FunCoup" id="B7FVU7">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FVU7"/>
    <dbReference type="PaxDb" id="2850-Phatr11189"/>
    <dbReference type="GeneID" id="7199557"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11189"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="InParanoid" id="B7FVU7"/>
    <dbReference type="OMA" id="MDDMVGG"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04088">
        <property type="entry name" value="EFG_mtEFG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000006">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="28"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="729" mass="80602" checksum="A8EB1582D102D4FF" modified="2009-02-10" version="1">MELNQVEQAQDIDYKKASSAPQREVDLGLYRNIGIMAHIDAGKTTTTERILFYTGKSYKIGEVHEGGATMDWMEQEQERGITITSAATTCSWNDHRINIIDTPGHVDFTLEVERSLRVLDGAVAVFDGVAGVEPQTETVWRQADKYKVPRMCFLNKMDRTGANFYFCVDTIIDLLGATPAILQLPIGTESDFLGVVDLVTMEAVVWRGEDLGASYDRIPLAECNDIPLVDDALKAKAEEYHEKLVELAVEQDEEVLMEYLEGNMPDIPTLKKLIRKGTLALAFVPVVTGTAFKNKGVQPLLDAVVDYMPSPLEVEAIRGIDEADQPVVRYSSDVEPLSALAFKVANDPFVGTLTFTRIYSGVMETGTSVYNSVKGKNERIGRMLQMHANERTEIKSAVAGDIVALVGLKDTTTGETLCKKEKAVILEKMEFPEPVIKVAVEPKTKADQQKMSEALIRLAAEDPSFRFSRDEETGQTIIEGMGELHLEIIVDRMKREFNVEANVGAPQVSYREAITTKAEIDYTHKKQSGGSGQYARVKLIFEPKEFSEEEGSMDFEFVSDIKGGNIPKEYVPGVQKGIESVLGQGVIAGYPVLGMKATLTDGAYHDVDSSVMAFEIAGRAATREGLRKAKARLMEPLMKVDITTPEDYMGDILGDINARRGLVGELGERGNIKTISALVPLANMFQYVSTLRSMSKGRANYSMKLANYEFVPPNVEEELKKGFTVKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVY5</accession>
    <name>B7FVY5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_11308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178788.1">
        <property type="nucleotide sequence ID" value="XM_002178752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVY5"/>
    <dbReference type="STRING" id="556484.B7FVY5"/>
    <dbReference type="PaxDb" id="2850-Phatr11308"/>
    <dbReference type="GeneID" id="7199579"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11308"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="InParanoid" id="B7FVY5"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="89" mass="9474" checksum="78E55D26CC2386A2" modified="2009-02-10" version="1" fragment="single">MLSSKRVLYVGGLADSASVQVVRAAFIPFGAVKSLDIPMDYVSGKHKGFAFVELGDPDDVTEAIFNMDGAELLGRTLKVSLAQANQISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWJ5</accession>
    <name>B7FWJ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_19615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179171.1">
        <property type="nucleotide sequence ID" value="XM_002179135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWJ5"/>
    <dbReference type="FunCoup" id="B7FWJ5">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FWJ5"/>
    <dbReference type="PaxDb" id="2850-Phatr19615"/>
    <dbReference type="GeneID" id="7200190"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19615"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="InParanoid" id="B7FWJ5"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13667" checksum="4BE01C1BB2CE9EA0" modified="2009-02-10" version="1">MVKAHELRNLNKDELLKTLTDLRKELSELHVAKVTDGAASKVAKIKGVRKSIARVLTVHNQQQKEGLRKAAAGAKYKSKDLRVKTTRAKRRALSKSELKQKTHKQCRREAAFPKVKFAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWX3</accession>
    <name>B7FWX3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179455.1">
        <property type="nucleotide sequence ID" value="XM_002179419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWX3"/>
    <dbReference type="PaxDb" id="2850-Phatr34868"/>
    <dbReference type="GeneID" id="7200107"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34868"/>
    <dbReference type="HOGENOM" id="CLU_689778_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWX3"/>
    <dbReference type="OrthoDB" id="53578at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="400" mass="44128" checksum="F8AC8E3910CECEC2" modified="2009-02-10" version="1">MFSSARLDTSSEGSSDFFSPISASFFKTTSSNKVCASSLLPTSHDTSWIGARMSPIRSFDQEEIDEDDDEYREATSRYQLALHQSLMASASVANERTTLLSKPSTSQLFVKNHNSINPSTAIHPLWSPARNGPENTILLDAQSRGGEPRCSWENGRTRHVGILLCLFSGLHWVISLVISLSQGRMGINWGYHQSDLISSGLSGTWKTAWVSPQVLFTYGGAITTTRRILSLSDCWRIPLSWTCATSLWEWFFGVCAWILIGNSTGQGILPHWSTHIGVFVASAVCGQLSFVAWQFANPYLLVGCLLWGTVGVLTHQASLQQQPQLFGMAAFLVFWSWVVQPYNSVWGMTLAAFWGWALAESEKPSKKNLWEGCTTKGGIATAFCISLIVAPVLYIAFTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX84</accession>
    <name>B7FX84_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_45308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179509.1">
        <property type="nucleotide sequence ID" value="XM_002179473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX84"/>
    <dbReference type="STRING" id="556484.B7FX84"/>
    <dbReference type="PaxDb" id="2850-Phatr45308"/>
    <dbReference type="GeneID" id="7200013"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45308"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409612_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX84"/>
    <dbReference type="OMA" id="DYLCPNE"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852778" description="Ribokinase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="32"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="12">
        <location>
            <begin position="436"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="709" mass="78583" checksum="3D82E400F00D948D" modified="2009-02-10" version="1">MLVLRTEALLALFSTLLLTSVCVDASGSRPHRIVVIGSINADTFLPVDRIPIEGENLTLLPGKLPVVDVPGGKGCTQAVAASKLLAPVGGSVSFVGQFGNDVAAQILQQSLVDAHVDVTFCSHHENIPSGRGYVFHTTSGQVSAVVSGGSNELGWLEWEHAWEIYNKDRNQILLQGKIDKLLQDCRLVMLQCEVPEYVNRLVARCAAQRGNILVVQDVGGEDRGMNEEHLRHCDYLMPNESELRRLVRSFGGPENDSDIETMAKFLQARGARNILVTQGSKGSTLVADDGTVIHQPAITIEEVLDETGAGDCYRAAFCTALCEDKSLQQCMEWATAAGACSVERLGAVPSTPTRGQVEDRVHTNWVERSVLDIPRGDGLGFRGGAKSFPFLIGSRLNSMKDRPELWDGALDDPREYVRRQSTIKGLTCVDFNFPQHFHTWSNEEAAKSLEMAGLRAGAVCLRYPSKFARGAMNNPDYELRQEAIELTKHAAQMARDLGAKEVVIWSAYDGYDYPFQVDYDEKWDELVGAFRECCDAYPDIRFSVEYKPTDENTRFFTIPSTGAALLMVNEVDRQNFGLTLDVGHMLMSGENPGQSIAMVGRAGKLFGVQLNDGFTRLAAEDGLMFGSVHPSMALEIMYQLRRTKFDGHFYFDTFPQRSDPVREAEYNIRRVKAFWYAASSMDADRLKRVMDEHDAIGALELVDDSLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX88</accession>
    <name>B7FX88_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_34984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179296.1">
        <property type="nucleotide sequence ID" value="XM_002179260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX88"/>
    <dbReference type="PaxDb" id="2850-Phatr34984"/>
    <dbReference type="GeneID" id="7199958"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34984"/>
    <dbReference type="eggNOG" id="ENOG502RWH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851167_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX88"/>
    <dbReference type="OMA" id="IDSTMTH"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="36850" checksum="5A2230EA0FD01674" modified="2009-02-10" version="1">MAIAITMEQIPKVVPVIKVIRVENATSRKHPRPDENGEPFSTENKQRYPHRTQQRHNARSRRRGASNNKSNQKDRGENKRKPLDSSIDAPSCSVCRQVDHPKYKCPKCRATYCSILCCRRHKDGLCEATKATIIETPNSKTLATTGVTSKYLTNDNVPMPLLSATASSASQRRKDEDDLDEGWKIDSTMTHAMQSSLWLRQELQDSGLRALITRIVNSSNTLDRDLHTAQERALQQAKDDHPMFQRFIDKLLVLSGVLERQREDSETTLETWLQQNNDGQHPLVLKALPRRIRHETTSSEKSSTVDDSSDGTTSESSDTSDGDESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXB4</accession>
    <name>B7FXB4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179309.1">
        <property type="nucleotide sequence ID" value="XM_002179273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXB4"/>
    <dbReference type="PaxDb" id="2850-Phatr45332"/>
    <dbReference type="GeneID" id="7199971"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45332"/>
    <dbReference type="eggNOG" id="ENOG502S515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086842_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXB4"/>
    <dbReference type="OrthoDB" id="196909at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852739" evidence="1">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="26390" checksum="35FFFDE1BB3DA1E0" modified="2009-02-10" version="1">MARFLLVLLGYSLVVPSVAFRASVVSRRTVRGADVSLGAASRRSFLVTNAAAAAAVSGWGLWTAPAAQAVGPVKITLEALSYQARPCPPDKPIPGQMAMKGMRGLCVTVEAKLKDAAPKDLEKVGVYGFITDASTGNSVLANNPDLSTDAGQFAMVESVTPKDKKILFEFVAAVPSDKDLSQYEDGIGPLDFESLRIISYPGGQQYGAINPCEMNEFSEECEVWEQENGSYQKAEFMVKSNPRTKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXE4</accession>
    <name>B7FXE4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrochelatase</fullName>
            <ecNumber evidence="9">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_45357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179541.1">
        <property type="nucleotide sequence ID" value="XM_002179505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXE4"/>
    <dbReference type="FunCoup" id="B7FXE4">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXE4"/>
    <dbReference type="PaxDb" id="2850-Phatr26952"/>
    <dbReference type="GeneID" id="7200041"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45357"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_4_3_1"/>
    <dbReference type="InParanoid" id="B7FXE4"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000006">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852783" description="Ferrochelatase" evidence="10">
        <location>
            <begin position="44"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="509" mass="56311" checksum="1B3B3119C7BCAD7C" modified="2009-02-10" version="1">MHKHRHIAHSIDSMRLLHRQRSVSGSLLCVLLVFLSAVSKCQCFSTHSSSRRDSLQLPLQSTMPLKVAAAPILEASPLVIEPTNPKVGVLLLNLGGPETGDDVEGFLYNLFADPDIIRLPGPLAPLQNLIALFISKRRAPKSRAAYESIGGGSPILKYSNAQADLLCQSLQRRYGMDVKAYIGMRYWHPFTEEALDQIQNDRIEALVILPLYPQFSISTSGSSLRVLQEEFSKHSEKYSKMMHTVVPSWYDRPGYVKAMADLLKKELDSFTDAQIAEAKQTSPDQKPLHVLFSAHGVPQSYIEAGDPYQRQIQECVAKISAELPYENVQVHLSYQSRVGPIEWLRPYTDDVLPELGASGVRNLVVVPISFVSEHIETLEEIDIEYRELAEESGISNWRRCPALNTDATFIDDMADLVVDALAEPAQSVTEACVANMVGDVELQPLDERLGINTGGVQGVGAEGLLYQAKLQEKERVNARVAMMGVLITLMVELATGKPFTQMLSSLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY13</accession>
    <name>B7FY13_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase glycoside hydrolase family 18, ribosome-binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179659.1">
        <property type="nucleotide sequence ID" value="XM_002179623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY13"/>
    <dbReference type="PaxDb" id="2850-Phatr35267"/>
    <dbReference type="GeneID" id="7200730"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35267"/>
    <dbReference type="eggNOG" id="ENOG502S4H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1158322_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY13"/>
    <dbReference type="OMA" id="RINIVHC"/>
    <dbReference type="OrthoDB" id="42420at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855481" evidence="2">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="240" mass="27227" checksum="ABEE4811560B9488" modified="2009-02-10" version="1">MRPRTNSIGTLAVVVVLIIGVFRESSVSTTYAFPITPSTQHRVSHRERVPVLKGYSRSSPRTSKNTERSKRQERVGHLVRTEISNILHGGVIKGQDAEYLDAELRQRISVVSADISPDLRQARISVSVRAPPRNDQAEYNPAVDKRRAYAWLVRNTKPIRHTLAQRMSHMKSCPNLSFVQVDVAAAVDVMYLIDKVSQGYKRDKVDLFNGENVPTGVMDGIDFDEEFDEEDWDEDDEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY49</accession>
    <name>B7FY49_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polycomb protein VEFS-Box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_35303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179873.1">
        <property type="nucleotide sequence ID" value="XM_002179837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY49"/>
    <dbReference type="STRING" id="556484.B7FY49"/>
    <dbReference type="PaxDb" id="2850-Phatr35303"/>
    <dbReference type="GeneID" id="7200748"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35303"/>
    <dbReference type="eggNOG" id="ENOG502T280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431806_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY49"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21521">
        <property type="entry name" value="VEFS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="7">
        <location>
            <begin position="102"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="233" mass="27112" checksum="94B077D2E7B08F9F" modified="2009-02-10" version="1">MAPRIICQSSAKLFYLKGIPVFLRQISMDTLWIHMNRNHEGILFRALRAEDGTIHISGKRKKESDFSPDGLNALYCLEVVKDDASSQSFDLEIAIRNGLRPPKRAYYHMTNFRKVAIGEWMLDIDPEDSIDLMWRNQMDEAFLDDFDDITASEKGFLKLWNDFIKRQPHTPQKDIPKLTIEFVTQNYEIICKEGYHEEMLKHVTNLWDEGHINGDDLFATIVAYNNLVPFNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY62</accession>
    <name>B7FY62_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_45584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179684.1">
        <property type="nucleotide sequence ID" value="XM_002179648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY62"/>
    <dbReference type="STRING" id="556484.B7FY62"/>
    <dbReference type="PaxDb" id="2850-Phatr45584"/>
    <dbReference type="GeneID" id="7200366"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45584"/>
    <dbReference type="eggNOG" id="ENOG502QYKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039979_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY62"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="544" mass="55434" checksum="6CCDD0F617F6EFA7" modified="2009-02-10" version="1">MYTMTDRPAVLQFQRSPNRKSERSRLNLFPKVRKPVSTAFGLLAVLGWIVPATNCFTAPIALSTARLRGVPPNNPQVVPLGFPVQAWIPLSAKLDADDTQPEPSLFGFPRDSVGNPLVLLLLSQFILFIGVGAVIPSIPLYGKEIGLSSATNGIVISAPAVALLLGAKWGGNFADRARKPAMLMGMAAIAVADIGTALATNIVGLLVARLGLGAGRCVSEAGERGMLADLAGLAPNLRGRALAAQQATIALGIAIDAPVGGIVVETYGVRASFLCVSFAAVLTLILYIFLPETIGATSRATSKSRQLEVETPIGAPGKTLDSAKFYISEGDWGKLLSKNQWRGLALCQCGASFGFACKIASIPLLAVNVLPGGAVGAGALLSAAGLSGLLGAPVGGWLTDRTSAKSTAILSGTFSAISLMLVPAALSLSATSSMGSFLIPIGVPQIGLQSAAFSAVVLGWSVGASAQGPALTAYAQEMAPAGAEATALALPRAAGDGTYIFAPFILGIVADTILGMPGIECAAAGLATLFGVFALGVLCKDDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY70</accession>
    <name>B7FY70_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179885.1">
        <property type="nucleotide sequence ID" value="XM_002179849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY70"/>
    <dbReference type="SMR" id="B7FY70"/>
    <dbReference type="PaxDb" id="2850-Phatr45590"/>
    <dbReference type="GeneID" id="7200372"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45590"/>
    <dbReference type="eggNOG" id="ENOG502SH8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417724_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY70"/>
    <dbReference type="OrthoDB" id="46074at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="713" mass="81949" checksum="DE78618DEDDB7500" modified="2009-02-10" version="1">MRKGARDSRVTGAIFLKVVFVAECRRRRREAKAECRRRILAFFCDQRDGRARKEYTCVAPSRDKRKPDETPKIQTSSDEKPMVLSPAGPKYNTANSARVVDSEQEAVYHNLIQPVKCFYFRAISHRVPFCLGAMLRTGGKLLLAGRPSLQITPSNHLGVRFYSRTSTRPEEEAAATKKTSREEKLHNKLAAREYNERNASYKRQVSLLRSSYAGEVAQQRAADKAEQEALERELTRRRLERQRQKNIRSAQNALRQQELCEQREKEFNEHLGLMQQQRDAKHERFSAARQFVIDELEEEAPLWLTSPEEVEARFTPEATQLLWARPGGVLGAPNPSIDSHFWQYETHTWHMNRTYKSQRAALLEELEEMAYEEANVDAKFWTPERVEEQVQLEEKARLRAMVHSTGRTELLKKQRAMLDEENTISEGEIPKPEAVPSMRVLNDDMALEKEGARLLMEDPTRFFLFDKDASVPGEEKSGEGKYSGPTLGSPIGLRDTLRETFITVFPEPVGKFPRPDTRTEREKKQEEREARLLAAAQAESKSAETDVEMAAEDRSLEEMGPDLDYDNMKLNNGDEEWEKGLDPVADRDIINTPYDRRYSEDDIDWVLERLEGNVEHFEQQFSQEMLSLQQKTKAALEMEAKQNDGEKSELEPTSLEAALLSLSDKELMALADLDQRFADGEKFTDEEFSEAAKDISGLTEDQLRVAMTRDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYE9</accession>
    <name>B7FYE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_12198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179725.1">
        <property type="nucleotide sequence ID" value="XM_002179689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYE9"/>
    <dbReference type="STRING" id="556484.B7FYE9"/>
    <dbReference type="PaxDb" id="2850-Phatr12198"/>
    <dbReference type="GeneID" id="7200441"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12198"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244410_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYE9"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="24780" checksum="FD09BAB3831B6555" modified="2009-02-10" version="1" fragment="single">MVDPSTGDTSHIDEVRREADIAARLHHPNICDLVGVAADLECFCLAYDFCEGGSLLSLLTDSRRYYEYLPIALDVANGMAYLHNRNVIHRDLKPSNILLTRDHRAKIADFGMSVANAGQELTAETGTYRYMAPEVIRHESYSSNADVYSFGVCLWQLITREIPFATMTPIQAAYAVAEGRRPEIPSTTPRRLQEIIMACWDQDSHRRPSFTYIAMALADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYJ4</accession>
    <name>B7FYJ4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179752.1">
        <property type="nucleotide sequence ID" value="XM_002179716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYJ4"/>
    <dbReference type="PaxDb" id="2850-Phatr45689"/>
    <dbReference type="GeneID" id="7200430"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45689"/>
    <dbReference type="eggNOG" id="ENOG502SH1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401428_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYJ4"/>
    <dbReference type="OMA" id="SPPPWWH"/>
    <dbReference type="OrthoDB" id="47695at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="686" mass="74620" checksum="E90EDEDC27FC3B2E" modified="2009-02-10" version="1">MEGNNPFGAPTAAAAVPAGSTTYQDTAVESGGGNPFASPSSPDPYGTNPYVTATTAPDPSSAYGAPSAPNAYYGAPQPPPPPQQWNTGYAASHANPYSTTAPTNPPPQSYGNALVPAPQSANPYAAAVVTPQSQSQPSQYASQAMVPSTQAPVNPWSVGDYHGTATTPAAGFDPFAPPAPTQPQPGYASAGSPPNPYANQDVFGDSTTPAQSAPLDDENPFGPFDAPAPTPAPVTTLDHYQSRALERREDHGPPPPQENQTPRDYSDAIVPHNPSGEDNPYPVGSSERNRYSQELARQAPPGASPLPKAELVRKKGFVLSRISFRTIVMKKWKQSFWVQYGPHTMLWFRTQADFDDWLNNPYHNQQQRNFMIKLAVNFVHDLYKPNVRGYQVTQCRTKGYGNKLVRQFKLERWMDYGPTIAAAFGSYDPKEVDALREALVECMRNTPLSGGIRATGAVRQDYAEPHDDNGYDRHHQDNNGHHDHHHNGDRGDYEGHSGGNRGPPVDYHNPNNRNDNHQTEPESVAYEEDLLDVDNWDDVGTAGGQSSYGPDSSTTPSQVGYPSYGQSQTVPYGQPPQLQQPFGQQQPQQPYGQQQPQQPQPYGQQQPQQPQPYGQQQPPQPQPYGQPPQSYGSYPQQHQANATPNYQRPTPNAPAAYPGAPAYGNAPANPWDTPQPQPTYAAQNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYT3</accession>
    <name>B7FYT3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180224.1">
        <property type="nucleotide sequence ID" value="XM_002180188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYT3"/>
    <dbReference type="STRING" id="556484.B7FYT3"/>
    <dbReference type="PaxDb" id="2850-Phatr45824"/>
    <dbReference type="GeneID" id="7201077"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45824"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582062_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYT3"/>
    <dbReference type="OMA" id="IAMYVVF"/>
    <dbReference type="OrthoDB" id="42089at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF681">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="141"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="580" mass="63542" checksum="66517ED9AA6C6E04" modified="2009-02-10" version="1">MATTPPEMIPLVASQLAPASYQTTGKPVTELPRTPDMRRKLSQLKDDDDDDDSQEHKTTVWQTFIHLTKGYIGCGVLSLPWAVSQLGVPLGCTMIVLMSCWSSYNCWTVVKLKRFIERKNVSVGNYVPQTSAIDDAASDTPSNVSNNTNITYPDVGEWAYGKQFNSYVTACVCIQQLAICTVFLSFIGENILAVLERMEVHMLSTHAGVLTLALPVVLSLSYLPNLKSLSPVMAAGSITLMVGFGVLGYVIVKFWDERPETTPTINVSQAPLAVCAILYSYEGICLILPVESAMKDPQHFKPVFVASMATVALILALVSSLSVMAFGEVTNGSITAFLVKEFSDNENISLWLMISNTAVSLSVLLTYPLQLFPALELISPWVQSKFPPKTDAADEDDLDAFEPLPPLPEHEVASIGSHEYDNFEFDVDEAEPAKNGDNKDEDDTSRAGMSSVTSMFPEMTMPGDSPMLRTALVISTYLVAVVVPNVQALISLAGALAGSSTALLIPPILELAFIKHLETDASQEEVARVDERRWRLLTSMRDKWLFEKVKSYILLALGFVFCVFGTYASLADIVRIYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYV4</accession>
    <name>B7FYV4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180233.1">
        <property type="nucleotide sequence ID" value="XM_002180197.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYV4"/>
    <dbReference type="PaxDb" id="2850-Phatr45835"/>
    <dbReference type="GeneID" id="7201088"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45835"/>
    <dbReference type="eggNOG" id="KOG1935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250710_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYV4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="710"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1462" mass="163013" checksum="C5CB9A3A3DC0B44F" modified="2009-02-10" version="1">MNEKDLTAENRGPPKKHVWLFHSMAATPWPYMVFLPTVFIFLIAFGWTREDIIEDEVASIWIPTKGSYAKDLDYGAQLGRDDLAISSFAAMAIARDGKNLFTESRLEEIRARMEAAEGTTVTHNGVTYTWQDMCALNSFPYEFPCARLSPMDLFQEARWFFDETSKITWYNEVLQNLLVKPRIPRFGVMTESCASPASDVCDFIVALRTNPTLVGQPAETANPLLLFSDIGNMEMSDPCRICIEENYQSQIEQLFSLAKPVFQVLSAELQRALQVGFANDTEGSAQVGAMLSKTAQLAQSITIEDVKDFYQYFVTRGVYASLGAPAYIAGYQQLLPLIELCNPAFGLTCPSTSVPNTTEAEAALLAHADNSFSPVSTAGAPFPFWSESNGTGNLFAGSNPVSGSGVDMSGEMLSIVGYLDLLNFGQDDWNPLYSNGYLDPVTPDPTWSALVERNPLFNWFMASVTEADPGLVCGNDVLTGTDTPSPEFNAATAGAMAQATSRWCTQYDLPTAEEPEGTFTKQHFARMWYDLLIASDSFLGVTEGEDDPYTWTTGQGCGYNLGGERDPYTGRDEQSILFNASRELYFIDEGETIGVVSRNLLFGDVTPRVGDYSFENPLQEVGLVQSLYASLRPPGIVERVRNCNRPGGAVDISVEDAEDILKLYKEEMENIWSRGWDDDNAGEVQFVGFFDDNGVIGTTGRMLQQITLDNTTLTTISILLIALFSVLFLFSLDWVESRVLITLVGVALVVLSFFAALGFAILIGVKISVTIAWTLPFVILGLGVDDMYIVLLSIKKQGGYREHHYLKAMKEVIVPVTMTSLVNACMFAMMNISDIPAVYLSAQCALYSVILLYLAIITCFPAYCYLDMKRQAAGRKDVFFCLKQENAPSEGKAEDFRNTFLYDKFYKPLVLGSARTRMFTHTLIMLGTVALFGVGIYGITEREVGLGLEDFFPSSNQANTWATTRTEALASWSMGMNWGNIEYTDPDTQMKMIKQFESVVETPHVAEVDTKQLWMANFLIWNSRMCLDNFDRSEFAELECGRDQFHNETQSSCEATWVPNQFGLRQKIIVNPTDEMCYPNEGGICRSGSSMHPADLEDMGILDPDSVRDEVYCPVVSDWTDEKWQFCLTQWRAKTGFSGGRFLLDDPQGSETDCTGVYEKDEALTWPIPFSSGPTMYSFDMFSHEETLVMMDETRTFCDDDPDLQCWLTGIAFDYWTQISSFFWYDGIFTVLVELGGYSTLVGFFISFVFLFTKLSIEGLYSRRKIFFGSLIGAGLIAMTIILTLISVVGLSVLAGVSLTGFSNMSFVLSVGFAVEYSVHIIARWLRANSSYSTSLSRVQFTMSFLMLPTFMSFVSSTIGVVCLAFTEFNFNQTFFFKPLIIVMFTSYFFGCWWLPAFLTYLDFDIVKMGKSAGIESEYLSTSTSPALRAAGKELDDDDEGESTPVDEEPRKEHEASSEEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZI4</accession>
    <name>B7FZI4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180355.1">
        <property type="nucleotide sequence ID" value="XM_002180319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZI4"/>
    <dbReference type="STRING" id="556484.B7FZI4"/>
    <dbReference type="PaxDb" id="2850-Phatr46015"/>
    <dbReference type="GeneID" id="7200871"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46015"/>
    <dbReference type="eggNOG" id="ENOG502S4WU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892721_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZI4"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855641" description="2Fe-2S ferredoxin-type domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38343" checksum="C81792CFA802F097" modified="2009-02-10" version="1">MRMSVLLVFLCYAITAGAFHNRVFLGSQSIAISSARSPISVLHAMSDSIIDEDSSVSKFSGAGPVQVDMNIYNLPFETVLEEWTANMVPATPMQEEGIYLGAKNSREHLVDVVQVEFPRLQDMGLGIQLMELAGGREDSLGITIVEGLVEGGSAENSDILPGDCITKVAVRKSSSTSAPVDITAGMDLTETVEESAVTTECLGYDATVSAIVSLPPVSSEGETFVLTLKRLRRKPKINLTLQYPPEMNEPDVKLELFAGENLRRSMLVKGVKLNDALSRRFDSGGIGDCGAEGTCATCAVKIVQGGNLCNPRAQQEAQILVKRANWRMSCKTIVGYGMKEGSMTVRVSPRQWADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0P4</accession>
    <name>B7G0P4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180709.1">
        <property type="nucleotide sequence ID" value="XM_002180673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0P4"/>
    <dbReference type="STRING" id="556484.B7G0P4"/>
    <dbReference type="PaxDb" id="2850-Phatr12762"/>
    <dbReference type="GeneID" id="7201482"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12762"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="InParanoid" id="B7G0P4"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="282" mass="29388" checksum="E33D9F0E15CBB74F" modified="2009-02-10" version="1" fragment="single">QFPGAPIQVGRQRLADGGPLHALVINNKVSNVCAGGDGVGNAELVCNAVAQELDLPNGASSVLPSSTGVIGWRLPAQELATDVVPKAAKALQMESALAAAKAICTTDRWPKVRSQTLSNGARVVGIAKGAGMIEPNMATMLSYIMTDAIIPKATLQTMLTEAVNGSYNSISVDGDESTSDTVALVASNVVSNTDEAEFRDSLRVVCQGLAQDIVRNGEGTGHVLRVHVLKFPGTDAEARRLGRHVVNSPLFKCAVSGNDPNTGRLAAAIGSFMGKFKNDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1G6</accession>
    <name>B7G1G6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxylase</fullName>
            <ecNumber evidence="3">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PEPCase_1</name>
        <name evidence="10" type="ORF">PHATRDRAFT_27976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181027.1">
        <property type="nucleotide sequence ID" value="XM_002180991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1G6"/>
    <dbReference type="SMR" id="B7G1G6"/>
    <dbReference type="FunCoup" id="B7G1G6">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G1G6"/>
    <dbReference type="PaxDb" id="2850-Phatr27976"/>
    <dbReference type="GeneID" id="7201832"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27976"/>
    <dbReference type="eggNOG" id="ENOG502QPVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_1"/>
    <dbReference type="InParanoid" id="B7G1G6"/>
    <dbReference type="OMA" id="WAQYETQ"/>
    <dbReference type="OrthoDB" id="1365747at2759"/>
    <dbReference type="BRENDA" id="4.1.1.31">
        <property type="organism ID" value="4707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.90">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000584">
        <property type="entry name" value="PRK00009.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523:SF6">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111877" checksum="C05671AAA863609B" modified="2009-02-10" version="1">MLSSSCRRSFLAAKTRLRSCVTTSLSTGCPWSAISSGSTSRHIDRFFSTHSSFDEPNPSLFGASPLQASTVSSDATSIPSNEADRDIQLRADIKVMGSLLGRIIQTHEGAEVLEKVETMRGLAKTWRDQGAGRDPSTKQAADQTFQNLAAYAKSFTDAELFTVSRAFTHFLAIANAAESHHRGRRLKQSRLLSDESSGALYPKPDSVGGVLPSLLAQGHDADAIYDALTSQTTELVLTAHPTEVNRRTILNKKRRIQRILTMADQQRQLGASSVFEQAELNDALYREISSIWLSDEVSRIKPSPETEAEKGTLVLETVLWEAVPTFLRKLDATTREFLGKPLPLDSSPIRFASWMGGDRDGNPNVKPDTTRQVCLRNRQKAATLFARNLRTLEAELSLTTCSREVREVVGAAREPYRIFLQPMIRKMEATTDWAAQELAILQKRRSGDKSASGIASVASTNVEGIYLDQEEFRAELLTIYRSLQETGNEVAASGILTDIIRNLSSFGLTLIPLDVRQESDRHEEALDAITRYLGLGSYIQWDEQTRVSWLTTQISSKRPLLRAGVWYEHPDYFSPTAIDTLEISRMIAEQHEGSLGAYVISQATSASDVLAVLLLQLDAGVKKPLRVAPLFETLDDLNGAADTMRQLFSLPAYMGTIGGKQEVMIGYSDSAKDAGRMAATWAQYETQETLAKLAKEFGVDMTFFHGKGGTVGRGGNPQTFTAIMAHAPKTINGHFRVTEQGEMISQNFGYADRAERTMDIYTAAVLAEKLSERPKVKDEWRSMMKILSDISCEAYRQVVRKDERFVPYFRSATPELELSNLNIGSRPAKRKATGGVESLRAIPWNFAWTQTRFNLPTWLGVGDAIGQLLKSDRAPLLRELYREARAFQTMVDLVEMVLAKSEPAIAAHYDSVLVKDPKAKELGKEVRQLHMATEEAILDLTEHKKLGENNAVLQRALVVRNPYVDCLNILQVETLDRLRQVEEGKEDKVLKDALLTTITGVANGMGNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1J5</accession>
    <name>B7G1J5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe-S oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181040.1">
        <property type="nucleotide sequence ID" value="XM_002181004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1J5"/>
    <dbReference type="STRING" id="556484.B7G1J5"/>
    <dbReference type="PaxDb" id="2850-Phatr13125"/>
    <dbReference type="GeneID" id="7201681"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13125"/>
    <dbReference type="eggNOG" id="ENOG502QWFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050695_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1J5"/>
    <dbReference type="OrthoDB" id="418407at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="ArsS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_ArsS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728:SF1">
        <property type="entry name" value="FE-S OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="SLR0304 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal" evidence="6">
        <location>
            <begin position="179"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34283" checksum="7999A7050DED0842" modified="2009-02-10" version="1" fragment="single">LDENVPGPGLRRSTTKILQINIGLYCNQACGHCHVESSPLRQEMMTAETAAQCLRLLEHSPSVTTLDITGGAPELNAHFRYLVRMARSLRPDLEIIDRCNLTVLQEPGQEDLVEFLKENGVRVIASLPCYSETNVDQQRGSGVFERSIAALLALNEAGYAVPGSGLHLDLVYNPLGAFLPPEQTKLEAQYKSQLADNFGILFDALFTMTNMPIKRFADFLHRRGELQDYMELLVRNFNAGTIESVMCVNTVSVRWDGKVFDCDFNQQLGYGMGKDLTVFDVESLEELQKHEIRTDNHCFGCTAGMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2T3</accession>
    <name>B7G2T3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_21420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002181222.1"/>
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    <dbReference type="KEGG" id="pti:PHATRDRAFT_21420"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006686_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
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        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="743" mass="85148" checksum="68026A7972CB4E94" modified="2009-02-10" version="1" fragment="single">MTQIIDDNPQAGSGRPLPKKEADLFRGVVKHYEMKQYKKAIKQADAVLKKFPKHGETLAMKGLTLNYMSKREEAHALVKEALAHDMRSHVCWHVYGLLYRSDRKYNEAIKAYKQALRIDMENLQILRDLSMLQIQMRDLDGFAASRNTLLSLKPNAKINWMAFAMARHMTGDLEGAVKVIDIYLGTLSEGSAELGRCYESSELALYRNSILAEIPNNYKAALDHLVVCENIVLDRGAWLMRRAEYQLKLHDFSGARNTVLDMFERGMTEDHRIHSLYMCALLELTDDSICDEALRLSGTLYETQLLPRFPTSHAVQRIPMAILEGDDLRHVLDQRCRKELSKGVPSLCSELQSFLLLEVNGRYTRPTDPVDIKAHPVYRMIVKMIDGYAECLATTSKFSSNDEYDEPPSTLLWTWFLRAGLHEIAGEYSDGITLSEKCLEHTPTAVDVYELKARLLKSGGDIKAAVECLDKGRELDRQDRYINNQTTKYMLQAGMEEEALKRISLFTRDEGQPEKQLFDMQCSWYELELAACLAQKKEWGRSLKKYSAVVKHFDDINEDQFDFHAYCLRKVTLRSYVSVLRFEDRVYGEDYYCAAASGIVRIYLNLFDNPLEDDTAEPDYTKMSAAERKKAKAVARKKKKTAEKKEADKIEAENNSKNAKGGSTQLIDEDPFGKEFLNKDVLDEARKFSATLARYAPKRLESWILQYDVAIRRKKVLMALQALYKARAIDPDSSELFTRIVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2X5</accession>
    <name>B7G2X5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 7 helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181279.1">
        <property type="nucleotide sequence ID" value="XM_002181243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2X5"/>
    <dbReference type="STRING" id="556484.B7G2X5"/>
    <dbReference type="PaxDb" id="2850-Phatr47230"/>
    <dbReference type="GeneID" id="7201988"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47230"/>
    <dbReference type="eggNOG" id="ENOG502SQUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288287_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2X5"/>
    <dbReference type="OMA" id="LAMAICP"/>
    <dbReference type="OrthoDB" id="46296at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056517">
        <property type="entry name" value="INTS7_HB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24437">
        <property type="entry name" value="INTS7_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 helical bundle" evidence="2">
        <location>
            <begin position="658"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119927" checksum="430C82785274E369" modified="2009-02-10" version="1">MEQETRDASALIASLQQACRRPLFVDIVASRARLAKKRASGVVNEDDPTRRNEPLPPDASTSAQTSTQLQSRKNEAKPTQTWIELLQEATSLLPVLTEDQHGEVLRLASILLLGFVLPHSTGNELCLLENAPRHKYQTAEGSELDVMAGDDYILQMPLEDRLSKAVHHNDANEFGEYDTLMDPFVEVAFHQFLSEGITPLLERRPAHRTQVDLWHVIAMIIDPRPLLESLPDRLQRLNDSHAAYWLKTRRLMQSTTPVHFQANYDHRWRLAQLVARSATWPVLEDETATDPVGPLLYGAMFHLQTSLRCFGQRAISKRDAHIAHCALVSMACQARNVPLLLEEWRYLLHLTIKDRSLCPVDDCSRSETSEQILQPELPLPRTSSRFCPHVARGRLLGNFAVRSGRRGTSEPDLFVQEALRSLTDVIEWQTDCWDASDEAIVTEDSRLYPPCLLESLLCATKQLACFRPAVNEEVVQCAIQLLRHSHCGIASEAANMLVMVFHYAPKHSVDSFVFKILESIKLIMEHTAKSLLFVEDLVGSLAQHSPPFASNLFLHLLDKTSKVANREAIDRLVAMVATNCPMVVARNYNKLFTMFQNRTELSPHIAVALLSSRQTYFFNAESDKHDKITQNIVSLEANGWTLFQIARQCLLLGNFAQALTLYKAVASSFLLSEKNYVWVCALEKIASGEALLIQHGATGIPHAAEDLHTAVSYLQFLQSFSDVRKEGFSFQIRFLLLRLDFLDLVTILRHLTMQMRLTASGPTKHTRSYNHLRNTIIGFGALASRYKGAFQRHGMCFKYGFSGTCLRVLEVLSSMMKEASVAVFLDIISVPMKKDVLSIDIQLGDARDPLSMLLRHLDELVVQPMRISVDSVARAAALLEVIEGVLMVPIPFPRDFMCLSPTIPAFLRLSAQPEEFNEHGVHRFTTIEAHPSVGFSFCATGRFPQALLQQSKKHVSKALIWYQVYYDGPLREDEFQPDEQLDEYHLTPPIQASIAAKVSLLSTSSPAVAPLSLDGFFFISIDCPPLFDEGWYSIKACLGGRDVSGGEWEIPTNGRTQSISIRNTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3K8</accession>
    <name>B7G3K8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_37727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181809.1">
        <property type="nucleotide sequence ID" value="XM_002181773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3K8"/>
    <dbReference type="PaxDb" id="2850-Phatr37727"/>
    <dbReference type="GeneID" id="7202604"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37727"/>
    <dbReference type="HOGENOM" id="CLU_102749_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3K8"/>
    <dbReference type="OrthoDB" id="49018at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="169" mass="18258" checksum="8928DA6B42892870" modified="2009-02-10" version="1">MSPSADFTISDFPHKVLNPIATDTIAPSYASLLLAQRQLSTNASAIPSLNGGGAHGHMALTLTADAYAELSNIPFVIPVAPPADPEPGATQPQITENNQLHKRAVAIHSLYVAVNNALRRQLLDAVPRVYVCDLEHPQFAYSHVTCLDLLDHLWRNFGTISASDLKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3M9</accession>
    <name>B7G3M9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_47514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181642.1">
        <property type="nucleotide sequence ID" value="XM_002181606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3M9"/>
    <dbReference type="PaxDb" id="2850-Phatr47514"/>
    <dbReference type="GeneID" id="7202289"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47514"/>
    <dbReference type="eggNOG" id="ENOG502SUFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618909_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3M9"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="24703" checksum="0D18F3C828CCEB99" modified="2009-02-10" version="1">MKDQIDLRAFVHTEVVSCRMDGVRYYRHLRSRVDELLTQPWRKVVRILLYHPKMQILNSALPLLLNYIREKQLPVVLLVAVQPWTIRSQDIPAARRLQRLSDVVLEVEGFASRQTYPPPAEFRTLHGLLHVTKVSTVTAAASSGHFADATVSKRPAAFLYGIKRDRRKLHIQLLHIPPEEYAEGGSSVGGTGVRSGGGRMSAETKKATGGCGSVGGSTHLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4A9</accession>
    <name>B7G4A9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHATRDRAFT_47620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181880.1">
        <property type="nucleotide sequence ID" value="XM_002181844.1"/>
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    <dbReference type="AlphaFoldDB" id="B7G4A9"/>
    <dbReference type="STRING" id="556484.B7G4A9"/>
    <dbReference type="PaxDb" id="2850-Phatr47620"/>
    <dbReference type="GeneID" id="7202668"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47620"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_2_1"/>
    <dbReference type="InParanoid" id="B7G4A9"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC46420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122122" checksum="2B94244AB9329E1B" modified="2009-02-10" version="1">MDSSVIHTGKRSNGSERNEDSPGGIEKVPVRISSADFPVTPAELGLLSSERNRGALADLLETGLQKLFLAEELQKHDDEEDPTPEKQLLSDIALVVKKIRESEQTGAVDEHSPAAVEADKHAEIASAFLTSALLRSSPEVGIFPSEVEKRREAFGSNRIAPKKIESFCKLCWHAIQDFVLVMLIVLGFISIGVEIYSLENDEECTTCWIEGAAILASVCIVVFVSAGIDYAKQFAFLRLTRSLHETNTKQVIREGKQVSIIDDDLVVGDILSINAHNLASIPADCVLLGPATDLKMDESTLTGESKAVSKKPGDVVLSGTNVQQGSAKLVVIAVGIHSVAGKIRAQVYESEDHRDDLGGDDEESPLFVKLNVLAKRIGIAGTIAALVSFIGSCIIGLAIKGNGAEALVDYMVVAITVLAVSVPEGLPLAVTLALAFSSMKMTQDQNLVKHLNACETMGCATTICTDKTGTLTANKMTARALFAAEQNYVVNDPADTLGNHVANHCGGLSPAVIDLLCRAIAINTMNETVLHFGENGDDNVRQSHRIRASTKGRSDQASLAEFFSEGKRFDFSSARKMMSWAIPYEGGYRLYCKGAPEVLLARSKSYINALSEVVDMTEDFRREFLSVSEGYARRGMRCLALSYRDVPMEFDIEGKSSVIKNADGTEANEIETEMTSYCPHWYRRPPSSRVTGDNPNTAVSIAYQAGILRDFHFLEGSIERVAANLKENVLMEGKAFRNQVYISRGESGSGEFNQLEFDKIWPHLRILARSSPDDKLTLAHGLNQSNLFVDKGLCQKYNLEDGINIFPDRQVIAMTGDGTNDAPALKRADIGFAMGIAGTQIAKDAADIILLDDNFASIVTAAKWGRNIYASIQKFLQFQLTVNISAVVTALVGSFAYQKSPLAAIQLLWVNLLMDSLASLALASEPPVDDLLRKPPVNRTESMITKHMWANMLGQAAYQITVIMVLLFAGPELLGIEAGHIVEKEREENSVHYTVIFNTFVWMQLFNEINSRKLKGESNVFKGVLDNYIFCTILLLTSCLQALIVEFGSLAFKVAESGLSARFWALSLILGAGSLPVQQVINQLYRLGQKYNIERNTSRKNRDRKLATLRVPGVATNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4C6</accession>
    <name>B7G4C6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_6606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181888.1">
        <property type="nucleotide sequence ID" value="XM_002181852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4C6"/>
    <dbReference type="PaxDb" id="2850-Phatr6606"/>
    <dbReference type="GeneID" id="7202677"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_6606"/>
    <dbReference type="eggNOG" id="KOG4526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093325_1_0_1"/>
    <dbReference type="InParanoid" id="B7G4C6"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF18">
        <property type="entry name" value="DUF1279 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="119" mass="12248" checksum="4F1D2473BC407CDE" modified="2009-02-10" version="1" fragment="single">EEITEKYGLEAGLATSLGEKDGGESAKSLLKKYGIAYLATSIPLAIVSFVICYALVDGGVDVAGLLSRVGIEANAAGEKAGTFAIAYAAHKAASPIRFPPTVVLTPLVAQLIGKEPDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4F1</accession>
    <name>B7G4F1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37922</name>
        <name evidence="3" type="ORF">PHATRDRAFT_47655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182063.1">
        <property type="nucleotide sequence ID" value="XM_002182027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182065.1">
        <property type="nucleotide sequence ID" value="XM_002182029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4F1"/>
    <dbReference type="STRING" id="556484.B7G4F1"/>
    <dbReference type="PaxDb" id="2850-Phatr37922"/>
    <dbReference type="GeneID" id="7202687"/>
    <dbReference type="GeneID" id="7202860"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37922"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47655"/>
    <dbReference type="eggNOG" id="ENOG502QS7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104845_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4F1"/>
    <dbReference type="OMA" id="CVEIEMI"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoribonuclease L-PSP/chorismate mutase-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="185" mass="19985" checksum="0147BDB214DA38F4" modified="2009-02-10" version="1">MQVGSLPLSAFVPPPPPSAISFPVNRHMVKTEHIISELGLTLPPAPTAAANYQPCQRVDNVLYLSGHLPLRDDGTLHTGTLGKDYDVQAGYQAARQVGLNLIASLKHELGDLDRVEKIVKLFGIVQSTDDFHEQHKVVNGCSDLFCEVFGKERGMHARSAIGTNALPLGIAVEIEAIVLVRDTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4W1</accession>
    <name>B7G4W1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182307.1">
        <property type="nucleotide sequence ID" value="XM_002182271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4W1"/>
    <dbReference type="PaxDb" id="2850-Phatr47780"/>
    <dbReference type="GeneID" id="7202942"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47780"/>
    <dbReference type="eggNOG" id="ENOG502SQQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386119_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4W1"/>
    <dbReference type="OrthoDB" id="48436at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="716" mass="80414" checksum="7707DCB937EDC82B" modified="2009-02-10" version="1">MTLQHSLLPQLQRSRRLGILIALVVFQSVTVLLHKQTSVLHPPVPRDLSDPFVLASEPNGQEDLEPMSRIFLEGRATYTSECRRFKLTNITWGQSVAPFVDKVGAKVLVEQMGTSVKIVPTIAVYDTANISDFDAMYMKALPDSIIKPAHATGWTAQVQNKSYVCFKGCKQETHKFQSWLGEPSEIEQAHKVAKKVMQYTLSDVPSPEFQKKEPQYGFVPRRVLIEHRLPVERMKEYHWWIANGQPVFVCIRCDEGRTKRGSYYSSAFQKLEITSILEPCQHLSRPKTWEKMISIVKNMGEHVPGVACIDLYADDLDVYFSEITFTRGKCRTYFQPLVADALLYAMSNDILAAKSITADYVEKTVADRSWVHVSFDLGEPLLSTNKVVNATGFPSGPDLCRNQATANSSVCDHTIDSVASWDLHCVISKENALTAVGQSKIRTIGRIVQKIDWLLVLGLVVLLVLVKFGHKTRQLDRPGPQVFHCFLYLAAVAVFKTFQTHSAGLLSPRPIWYTVVESYQTFKIVHPVTSPAIALSHFATYWISVSAFFSKRLTTMLILWCLYEVCTAFVNEYFHFGEEDDSVRCMRVSFILYTKEYAINDVVRVYLLPPLFVYGYLLPKMMLYWFGPHGCATWTLTRLGLAARVLSLYGVHAPHADHNGGALGTANANHGGGKYSAGFFQTPRVTDTGLHGATRRDGTGGNQGYFPTNVNHSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4X0</accession>
    <name>B7G4X0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002182148.1">
        <property type="nucleotide sequence ID" value="XM_002182112.1"/>
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    <dbReference type="AlphaFoldDB" id="B7G4X0"/>
    <dbReference type="STRING" id="556484.B7G4X0"/>
    <dbReference type="PaxDb" id="2850-Phatr47788"/>
    <dbReference type="GeneID" id="7202947"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47788"/>
    <dbReference type="eggNOG" id="ENOG502RRCB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494762_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4X0"/>
    <dbReference type="OMA" id="LLKRGPI"/>
    <dbReference type="OrthoDB" id="43418at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="391"/>
            <end position="423"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="34"/>
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            <begin position="107"/>
            <end position="119"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="551" mass="62525" checksum="CFBC9C5100B2BF09" modified="2009-02-10" version="1">MSLEQVEVELDGRVVTLHDEEFEVHQDQGTGEDYGNEADDPGLDDDTEDAFDDDDNLDSLLSGIDIDRDFNLWNSFRSSDTVRRVSSGGEDSPEKRNNNHSDKTEHSTNTTAQQQNWNAVETQDMQFWASRIEREEVYSRRYRPTALENQELLELEAFLGNKGSSKRILRGRLFRTTSSTEEPNSQGNRKAWNALIHPEAPEPISVILKRGPVLVVPPLQSSSSTTMATTLPQEAELILLTHGFIVAVAVTNTSRRLRRDRKKNLQQVVERRFDRAVLWSQVEYVAHGPDTTVELCLQRSEGLIESAEGETLRFMCAHEVSHQAWLDAIEKIMIEYNIHHHTPRSQQHELGWQYCIVHKPGFTLAVTNRNPYDSFAPSNDAKSLDTLDVYNGMAPIHYATRTGNLTALEVLLQNGADPNLPDREERTPMYYAKRDQAPPEIVRALELHGAEPCSKVSLEQEGALFGQVAAAEAKATERRRQEQLALEQKQKAEQAQAEMNENMRLLQQREIQIDEMDDKAHQLSEGGKNFANMAAQLKQKTKAQRSWLPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4X6</accession>
    <name>B7G4X6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_38095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEC46052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002182115.1"/>
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    <dbReference type="GeneID" id="7203039"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38095"/>
    <dbReference type="eggNOG" id="ENOG502S9DC">
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
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        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC46052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="84942" checksum="A1F63B8707D2B5E2" modified="2009-02-10" version="1">MQKVAMPWTGAAVSKELYEWEKEFLANSIETSPLSAASRRTGNYGLTSSIGSVAEDDKVYKRDSSAIAWLTLSDQSPRLRSFFRTLVFDRETCEFTPLQSHFWSGVQGLLIGTLTFVWKNSIEFGIEFFWVILPKTLRNCGVFTDDNGWLPIWHYTWIFSVLTATILGYFADLYKVPGQDSYNDSVHQTGLVDFRTALSVLVLSTCGLWSGFSLGPELPLVILGGQFGSYIGYTLNQSVLHCRVMTLVGSSAAVAGFFKLPLAGAFFVLEILHRDGLQYYEALRPALFASVVAVETNRFLAHRNEHVFFQYPGTEEEMPNSLYLGVIFLALFGALAVGIPYIIGVNFCKKLIDSTYDWLEDEFGQDSERKSLNELRRLNNFKSTEPEPESEYLCGVFSTEALQAAGKAGLAGLILGWIAIYLPHTMFWGEAQLQTIIDRGATPLPIVGSDYPSGLGSQGFCMTDTQSSSPEPLSLTCLATIGVVKVVHVGLSLGTHIIGGHFWAPLLVAAPAAHLLTDAMGGVARALGHAGGLEAYKTIVILVVMGGAHVTVFRAYTAIAFILFLTVAGHLTELLTFLITALSAVQVLTTAWMERFVMYRSQGPRCDVVAAPEVVEKPDRFDDFDDDDEESGNSAADASVESETNPGDYLRVEKAKFYGGTTDSVEQCFGESDRSIPTPTKSSAGKGNTHKVQGNRRQLRRMTSSQLDLLEQPRQAALRKQKSLTLSGSARSLLSSGSSGRSVSTTSRSISSSISSSSCLVTQSRDHCGDPTWTLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G536</accession>
    <name>B7G536_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182178.1">
        <property type="nucleotide sequence ID" value="XM_002182142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G536"/>
    <dbReference type="PaxDb" id="2850-Phatr38156"/>
    <dbReference type="GeneID" id="7202976"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38156"/>
    <dbReference type="eggNOG" id="ENOG502SKKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G536"/>
    <dbReference type="OrthoDB" id="230966at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110946" checksum="E921BBCD574AE6E1" modified="2009-02-10" version="1">MAYRRFCLTNGTADVDSTGGSRSRFVWNYGSKYVDPTPKLRSNPTVFTLPALPYRPSAISSVPMSTSAHFKLSDFPHKVLDPIATLTVPPTYATIKHAQRQLMTNAAAIPTLNGGGAHGHMALTLTALAYADISDVPFVIPVAPPANPPPGATQPQITENNRVHQRDADIYNLYVAVNNALRQQLLDAIPRIYVRALAHPMFEFSNVTCLDLLSHLWTKYGTIKPAELQKNFQSMFTPWNTTEPIESVFLQLDEAIAFSVDGNDPISEAAAVRAGYEVIAHSGLLLLDCKEWRKLPLASHTLANFQQHFSLADDDRRLTATTGSLGYANVLAATPSLTPATVSDTLSLPFSALSVSQTSVSSPDMTYCWTHGTSKNRRHTSATCKNKAPGHRDDATATNTLGGSTKERGTATPMVNSSNTDYLNHITSLNSSVAPSPPSSHTSAIADTGCTGHYITVNCPHTHKLPARPSLAVRVPNGAVLRSSHIATLALPGFSPSACQAHIFPGLTSHPLISIGQLCDDGCTATFSATRLEIHRDTTLLLSGTRAPTTGLWHLDLTPAKPPATAHALVPNTPLADRIAFVHASLFSPAISTWCQALDSGHLATFPELSSRQVRKYPPRSPAMVKGHLDQQRANLRSTKLPPVGSPITTAPPAAAVPDLDPPDAHPVTRTHHVFAAHQRVTGQIYTDQPGRFLTPSSSGHNDMLVLYDYDSNAIHVELMKNKSGPEILAAYKRAHALFTQRGLRPQLQRLDNEASAALQSFMTSEHVDFQLAPPHLHRRNAAERAIRTFKNHFIAGLCTTNPDFPLHLWDRLLPQALITLNLLRRSRINPKLSAHAQLHGAFDYNRTPLAPPGTRVLVHVKPSVRETWAPHAVEGWYLGPALHHYRCHRVWVTETRAERVADTLSWFPTRIPMPAASSTDRALAAARDLVHALQNPSPSSPFAPLDATQHQALTDLATLFATVATPTDDPPAPATPLAQVRFAVPLVTAEHAPALPRVPIPAPALPRAVAAAKHANNRQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5T9</accession>
    <name>B7G5T9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRD6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRD6</name>
        <name evidence="1" type="ORF">PHATRDRAFT_48049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182601.1">
        <property type="nucleotide sequence ID" value="XM_002182565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5T9"/>
    <dbReference type="PaxDb" id="2850-Phatr48049"/>
    <dbReference type="GeneID" id="7203410"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48049"/>
    <dbReference type="HOGENOM" id="CLU_093662_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5T9"/>
    <dbReference type="OrthoDB" id="46933at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="246" mass="28297" checksum="0D8C226C059142F1" modified="2009-02-10" version="1">MQRLLSTVLVALVTLFGAISWLRQKQLHSEQALHDGGIDVIAIRHLDQTIMTPSPYNASTNCLDPKNRSACTTSRDLRFTRSRDNLAPINTSTFRMKLYWEPGYFWQEEDYERKWCWMCVDMCNVSSSIQVVNCDDDGGLAAPDRFRFIQQRTAMEVQIQEIGSRLCLQRQNDRVITLQSCNVAEASQRFFASSGRFAWGQRFEITPRGLSGECITQRHHPKAGEILEVEPTITARMSDTSYWNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V1</accession>
    <name>B7G5V1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_48059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002182572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V1"/>
    <dbReference type="STRING" id="556484.B7G5V1"/>
    <dbReference type="PaxDb" id="2850-Phatr48059"/>
    <dbReference type="GeneID" id="7203445"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48059"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559574_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V1"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SMP_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045050">
        <property type="entry name" value="Synaptotagmin_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774:SF190">
        <property type="entry name" value="C2 CALCIUM_LIPID-BINDING ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="8">
        <location>
            <begin position="227"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="530" mass="57513" checksum="6B0BBE47120FFD0B" modified="2009-02-10" version="1">MFCCRYVPFTVDERSKSPTQKTLLRPVKLGHSLQPSFSCCLKMRLSTSHRARQSALFVGGTKLPLDPSRGLGNDGSSPWTTSGSSATALCMSAHTSWPMARILPSTTATAMLTSASPGVGFLKLLLAFVSGGLFFSTAIAAVTACYAIGLDNVKRVWDIVKLVLRSVWISFTLALSAAKIALRQDGSWKWKEAWQVLKARLAETRQKAAEGVQAIRQEASLYAAAVGAPGLIVLQYVVDRLFPLSLAAAMEESLQDTLQTVKNRNVKKLTLVSFGIGKKTPKLEAARVYDLGDKGMAFDCDMEWNSQVSAVINLYTAGGLARLPVEIKNIRFDGVVRVILAPLTKAPPGFGAILVSLPSVPKIGLDVRIAGGDITRIPWLRSELMNAIQKGIADELLWPRRIVIPSTLPTATKPKPLLSKAELDLLVSTDPLLRAEKALQERPILRDQMEDAQSDVKALRKLTKIFFNPKEDANGTGHTTENPAGIAEGSELGDKTGNAPHVTPIDLRKHMATIQNGVLLGPIFQSFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5Z5</accession>
    <name>B7G5Z5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182487.1">
        <property type="nucleotide sequence ID" value="XM_002182451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5Z5"/>
    <dbReference type="ESTHER" id="phatc-b7g5z5">
        <property type="family name" value="Duf_900"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48096"/>
    <dbReference type="GeneID" id="7203266"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48096"/>
    <dbReference type="HOGENOM" id="CLU_800405_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5Z5"/>
    <dbReference type="OrthoDB" id="56538at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853022" evidence="1">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="347" mass="39042" checksum="D98C0E41DA1A1F93" modified="2009-02-10" version="1">MWVTILLAILNNRRALAADENSRFSYPGYVITSIDVEPLGKGHPTSRVKFHARIPGKVDDTTAHVLRDVVDSGETVGKWPFRSPVFHGTVVPPGQLQARLDAESPRVSDRWNPLQHRKALLCVHGFDSQPESWLRRCAENYGKSDELAIIPVIWPAGDKGLRDYMNDRNVFVPGAARAFQPLLDVASSLRKSLLCHSMGNFVLKLTAPPHQPSRTSGLAKRKLSAPPFEDVYMSAADVRHDVFDRAQNDHDDANLDYGRNIAGMAQNKVHVMHSRSDVPLMARRARHAGLRALGSNGANMKNLHPSLKGKVVNVDCYSWNKWTRKNNLYHSYFFKSEAIKYYEQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7G692</accession>
    <name>B7G692_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182534.1">
        <property type="nucleotide sequence ID" value="XM_002182498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G692"/>
    <dbReference type="PaxDb" id="2850-Phatr48182"/>
    <dbReference type="GeneID" id="7203315"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48182"/>
    <dbReference type="HOGENOM" id="CLU_904517_0_0_1"/>
    <dbReference type="InParanoid" id="B7G692"/>
    <dbReference type="OrthoDB" id="41409at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34379" checksum="5623F721DE9366E4" modified="2009-02-10" version="1">MSGFKVRFEPCAVLKVALAFAALMSVMFSVIRSNDSTRTAEHPKQSISLAKLGKKTPVLVMGLPRSGSASLHEFFRCNNVKSSHFCCGTSQKTSFACEPDQPTCGRCVHQNLNQSLPAFQGCGNFSVYSQFDVESGQPFSWFLPQHFALPLLHESFPEAVWILNRRADARVWARGVLHWYSVSRRVMNAFGLQYHHPTLIAAKIYDAPVRPLTEDGLIADISLSLARAENVTEHKRRLDELTSVYEAHLHRVRAFVTANPSHSMLEIDVDDPASGETLSAFFGGARASCWVFDAQSLDNDWKKFSLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6Q4</accession>
    <name>B7G6Q4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182897.1">
        <property type="nucleotide sequence ID" value="XM_002182861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6Q4"/>
    <dbReference type="PaxDb" id="2850-Phatr48317"/>
    <dbReference type="GeneID" id="7203788"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48317"/>
    <dbReference type="eggNOG" id="ENOG502T871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407411_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6Q4"/>
    <dbReference type="OrthoDB" id="45191at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855484" evidence="2">
        <location>
            <begin position="21"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="735" mass="81958" checksum="868EAF3F9839B8B6" modified="2009-02-10" version="1">MRSIVWSFVALLFAFEAVVAFAFVFRPRSKGSRIPVLSLQHQYLSPNVRSFSASTSTRTYMTWPGGNQFASSDNSLRTASNERTRQALIEAALSIEKSANRDALTTVRLVGKSTLPTTAEGPNVTCVVLTVSPTPDTFTEIDASVPCLLVPLRGNSNQLALLECVVRAEPLSMTSLYGYNLLFVNRDGDLYDNVPWASWTVDPSQRNRDAANNVIDAKFHMGKRDAYNRFMGKDVTGRSQVLARLRQQKQQQETRMARQQAPIQGDEDGTNAMVGLKRRILQVEIRELEMEIAELDYGLAVAREDDAKVDALREQKAVLTRDMEAARDRFKATDQISEVGTGAAEATWITGLFQDRRRVDKGEKPFPGVMGYPPEKSETSQDQLYRSPYDLLRQILKEQLNAEVIGSVLENTSLLEGTTSLSGVLILRRVAAQKSAKLLGEEVTVSDEDEEFGNPGIRGGELVVVECDADEAIAMSFACDVPLQVETSILEVASLMAQPVGGWSESRQDLLEWTSLNPELSVLVEGQAGNELSTERASPLRIPRTTSSLFDTVTQDPPASASKDLFPTDNPIQSLSQYDNMSNEDKARMLMALSNFDGKLPRPRTVRQSQRMGAGNALDALLLPLVDESVRRQYQIRDATQKGDMDLVRTLTEEKSQRQIAKEKAEQAREKQADDVADWWEAEAEFLEALRADATQDEGSYSRFLDRDDWYERSRQQQAKRVNKKQFGNLLDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6V7</accession>
    <name>B7G6V7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_48362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182923.1">
        <property type="nucleotide sequence ID" value="XM_002182887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6V7"/>
    <dbReference type="PaxDb" id="2850-Phatr48362"/>
    <dbReference type="GeneID" id="7203572"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48362"/>
    <dbReference type="HOGENOM" id="CLU_448707_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6V7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="4">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="622" mass="67680" checksum="E6B2BC4C8927BE1E" modified="2009-02-10" version="1">MAYECTLTNIFFAMTTHLFASILFVFWITCLVSDAENGNSIATDPHALSPSELFAMDPVHWTRMEKFSLSARDLARTRQRQVLLDIFTSLRMYSAISRPLHNWFTEWPSIIGDCCSFTGVECNTNGLITHLMLTNLRLEGKIPSTVNYLSELVQLRLDCNSLSGSLPTNLATLSKLRCPSIQESSRNLISPEAPAAPAVYPTIGIPSIPTSSLEPLITPSRAPATSTMSLPLVSTQPSGMQSLWPMQPSPSPTLVANPIPSNSPTENPNLASIGTLSVILPRAATGGSQKRGIIAGSVTSVLFIGFVIGLFLKLRLRRRIAKGPGCSASFASSEGFDEISFEPGGLFSIEEENSTDIDERSVVTTAASCSSILKPGRFSTSLDSKEEEVKRGRRVHFDGEDNDDDSWTTEEEQAKQIQSTREEARVAAVATPSTIRDRDGWVSWIMNPVFDARTWCGTPEPISTFSINGEDLLDVPDSPSTQSSVNSDTPIFPQSSGTSSEVFLGWETSLQHEATPKHRWRPLLGIVRRYNDETMDCTVAYSEPAPEYFLEAGTARHVGIDDTAAGEPPTARPEPWALPSQPSSALASAVSEETYHVVEDLPRTPGYGNAAISNAGQNMVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6W7</accession>
    <name>B7G6W7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_38809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182803.1">
        <property type="nucleotide sequence ID" value="XM_002182767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6W7"/>
    <dbReference type="PaxDb" id="2850-Phatr38809"/>
    <dbReference type="GeneID" id="7203637"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38809"/>
    <dbReference type="eggNOG" id="ENOG502SQGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673489_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6W7"/>
    <dbReference type="OrthoDB" id="46968at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46999" checksum="7B27464758D40D6A" modified="2009-02-10" version="1">MGVGVFVNFWVAIRVSDRQPSVSTRAESTQSVMSMTFAVSGYDESSLIRDRSFGVSVWNDSTTLPTWMKEYFDWHRTQRQLLLNETNYGQFTFLVVRCLKHDLKCGGTADRLKPLPFYVLLASRMHRILLFHWERPFLLQEFLVPPVGGVDWRLPTSWRRDQFSDTIEIKNLKDITPYLAKPHSGRYRKPLPAIACILYQSHDHGALQYNQLAVQQTKEATYEEVFRDCWNSFFVPSPPVQSRIDQLRQSLGLVPNEYVGAHVRSQYHSYNGNKKLKVLVQNAVACASRLRTEVRQSIYVTADSERALQVVGESSVGMRNLPVVRRKGDRPPLHLDRGVAYLAKSATNWTHHDDPRAYYDIFVDLYLLAGSRCIAYNVGNYGKWAILLSSNRSCTINHGKTTCRWKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G702</accession>
    <name>B7G702_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_22411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182820.1">
        <property type="nucleotide sequence ID" value="XM_002182784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G702"/>
    <dbReference type="STRING" id="556484.B7G702"/>
    <dbReference type="PaxDb" id="2850-Phatr22411"/>
    <dbReference type="GeneID" id="7203593"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22411"/>
    <dbReference type="eggNOG" id="KOG1207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B7G702"/>
    <dbReference type="OMA" id="YELVHQC"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="321" mass="34338" checksum="C7463158803E70C9" modified="2009-02-10" version="1">MNTRSPATTLETSRPSTRAPTGNNENTESDLEPPLASLSLSTKGRYFVVTGGTQGLGLAIAIQLKKAGAAGLFLVARSPDKGQAAVEHLRQQHQLGDDGKSTCQVFFLPTDLSDTKQVQTVFSRIEDLLSTTDVVSGLVNAAAITTRGNLFTTTSNEFDTQFFVNVRAPFLLTQALAVHCRKQQTQRTSQVRASIVNISSVAAYGGAPFITAYSASKAALSTLTKTNAAELAPHGIRVNAIQLGWTYTDNEDALQTAQSDRDWIQRADEGVPLGRILRPHDVAVTVVFLLSEASAMTTGTLVDLHPEYAHGLISLAPTDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G773</accession>
    <name>B7G773_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_38916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182857.1">
        <property type="nucleotide sequence ID" value="XM_002182821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G773"/>
    <dbReference type="PaxDb" id="2850-Phatr38916"/>
    <dbReference type="GeneID" id="7203689"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38916"/>
    <dbReference type="HOGENOM" id="CLU_786350_0_0_1"/>
    <dbReference type="InParanoid" id="B7G773"/>
    <dbReference type="OrthoDB" id="53035at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="333" mass="37601" checksum="EA1EA306FDECA42A" modified="2009-02-10" version="1">MLLLRPAIGVFAWYAYSAVQRQRLVRQGTFASMQMLSSFRQPDGDSLKLETLGQPVTAIADDWVYLTGRNPKLPTDSYRPTFRHTQHVACSFSNDGDTHGSRPHSSIALFGPRAVPLLSLRQLVTERMDLRPYVEEDLTKRLAWEHAMAECRPLLADENANSAAPLVPGAYSFLYRDYVNQEELLAMLCRRKAMETLLYRQTRATSLQVEDPTSNGNSSTSPSDQKCVLTDRAKMLGFLPVTIHWEGIVPRTTGDDQKCTIRWTNTSCRIGWQRLGKTIQQPSLAEKYRKDDWDVLLPPSSDTDAVNEGDIIVFYRQGQGKLVFARDSLISPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G784</accession>
    <name>B7G784_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182862.1">
        <property type="nucleotide sequence ID" value="XM_002182826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G784"/>
    <dbReference type="PaxDb" id="2850-Phatr38928"/>
    <dbReference type="GeneID" id="7203695"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38928"/>
    <dbReference type="HOGENOM" id="CLU_2297142_0_0_1"/>
    <dbReference type="InParanoid" id="B7G784"/>
    <dbReference type="OrthoDB" id="43448at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855902" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="101" mass="10824" checksum="3880AD2618D4904C" modified="2009-02-10" version="1">MTPLSVIIFFLFAVVWPHASSLQQSARNRRAFIGSAAALIGGTNFVTFESADALISSKYCASGVGDGCDDLSEGNELIKSLQEKSAAKRDQYAQASRRIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7B6</accession>
    <name>B7G7B6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182879.1">
        <property type="nucleotide sequence ID" value="XM_002182843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7B6"/>
    <dbReference type="PaxDb" id="2850-Phatr48488"/>
    <dbReference type="GeneID" id="7203710"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48488"/>
    <dbReference type="eggNOG" id="ENOG502SD6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033030_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7B6"/>
    <dbReference type="OrthoDB" id="38337at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="555" mass="62994" checksum="D58E03D00C08F69D" modified="2009-02-10" version="1">MLLSKEARDHDKDDGHRRWYHQISSLVSCRFQSFSKLASSDELTIMYTHCEGDFADHRRVSNRKLPVVVSMACVVASALLLLVLLPMASNQSPVNEPDATWPKLPQPRRLASNNKPRILYIITTLAEYNSGTRSTVRGSDRLQETLIPVVSEGVRSMVEGGYDVDVFLICHFTLLPERKALVQRALPPGVGLDVWNDATPLGYDTGKNPFTKLENRTLHLARQHRFAIKDRLLEYDVFVNFEDDMVIKSSHVDHFVKVTKELLRLRELAPDDVPKGTSGADASKMFYGEMTKGQLKRMIPGFIRVEALLDEDEYGAQKDTGPVPIDMDFGGPAGMQSINPEYCCHVSKETANHKIPESPASDKLMLWETNIFPLGVRKMPPSSWMDWVVLQRGPAQSKLDAKETIGDYWANRNNDYWPNKGRPAPQDFKYINNQGGWMATRQQLWEWHSEICPGGFLPPYESPHYRFDGLDMRNVEWYSGGMQLSTVRHACNMQRIIALDPDNFSRSLVYHSANNKQRQLADQGKQESFTKVNTLLGQLNTLKKIAEKAITKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7V2</accession>
    <name>B7G7V2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183079.1">
        <property type="nucleotide sequence ID" value="XM_002183043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7V2"/>
    <dbReference type="PaxDb" id="2850-Phatr48608"/>
    <dbReference type="GeneID" id="7194875"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48608"/>
    <dbReference type="HOGENOM" id="CLU_907512_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7V2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="31945" checksum="64B0B2F0CC3CFD20" modified="2009-02-10" version="1">MAEETTTRSLGTVKATLTAYQTLNNIGKNPLNDDGTVGGEESDSLVTRPHLGIVGSVAVAGLLAAIASFVLVTAHLVDLASVTLMLIAPLVVVQKHMLRKLGGMRGLQNSLRQSANRFMQQNLTLHMSVSKLSHNVESLSKVEGKLQGIAEKSGTKVDHLFDTVKENGEIQKHIKKALETKVMQQIMTACLQVDRDRNFTLGPQEVKILEMRLSNIPGVIFDKTRFDAFLQSDQGELALSDVCGIARVLRDNSVPEAQRIFRFAPQKVLQQGKASSPRRGLFGMGSARHDLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7Z7</accession>
    <name>B7G7Z7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_15145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183231.1">
        <property type="nucleotide sequence ID" value="XM_002183195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7Z7"/>
    <dbReference type="STRING" id="556484.B7G7Z7"/>
    <dbReference type="PaxDb" id="2850-Phatr15145"/>
    <dbReference type="GeneID" id="7194844"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15145"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G7Z7"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC45449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="162" mass="16602" checksum="67937BF69482B196" modified="2009-02-10" version="1">MEVAQCPSYAAALGYTGVAAAVCLSNWGSAIGTWKAGISIVHTGIRHPSSVMKNVIPIVMAGVIGIYGLIVAVIISQSIVTPSTERNNAYSTYTGLAHLCAGLCCGVSGLAAGACIGIVGDYGIRANKLFVGMLIMLIFSEALALYGMIVALIVSQHSYSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G808</accession>
    <name>B7G808_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183234.1">
        <property type="nucleotide sequence ID" value="XM_002183198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G808"/>
    <dbReference type="PaxDb" id="2850-Phatr39174"/>
    <dbReference type="GeneID" id="7194852"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39174"/>
    <dbReference type="eggNOG" id="ENOG502SGMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958000_0_0_1"/>
    <dbReference type="InParanoid" id="B7G808"/>
    <dbReference type="OrthoDB" id="497908at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="32461" checksum="44B48B0CEEA7F263" modified="2009-02-10" version="1">MDPIRHEESERMPMTLVPNRPLPEASFDAFDVKAVVLGYYSTLLCTRPGSGEAFAFRSDRSRRSIRSQHCSWTHPPEVFRSPSLYLKDQRDDEEDDNQRKPSNATPEPVNDVLSRFTAPRIDDPFLPLSDVLVAQIIAPSLQIAWLSLNHAPSPSWLQPIFATSTLYSSRGSLIAPTLIHGAALASCWIVGALAARAYQQDAIAADADGKLGTVLARVVQAGAFATGILILATQTDLFLEYGRWVQVGETEEIDFRLLVALVELSNDVFFEATTMVTWRLYLAWQSVRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8H3</accession>
    <name>B7G8H3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183344.1">
        <property type="nucleotide sequence ID" value="XM_002183308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8H3"/>
    <dbReference type="PaxDb" id="2850-Phatr48817"/>
    <dbReference type="GeneID" id="7195122"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48817"/>
    <dbReference type="eggNOG" id="ENOG502SWFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714695_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8H3"/>
    <dbReference type="OrthoDB" id="49522at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41203" checksum="35E75D38164BC629" modified="2009-02-10" version="1">MSHTNPHGTNRPTHSQPASPAQMSLMGGHELSVEEIQDLLGGVLDDEHNHHPLVSLTHAGLSEATDSTAAASLASHQQSHHALSYQRLQLQHYLTHSHSNPLLNSARSDDGNDDNNDPTDAAAPSSSSRALPHALDGKAVARSERKRSREKQRRSDVNQQFTALTTVLREIESTCDDVHARALPAFSPSNRADLIARVIGCLEALHGAVKRRKAENESLETQLQQAKQAGEETAAKLKESLMAPQSFGQNRVMMMVPMMIGANGPEAIPQGTMPPQMANMMSYMTAPPQAYMTAPQPTLQQQQQQQPPQSAPSHGTPANESNSAPPATAPATGNPSNTFPFVMPPYFMPSAPTPADAQSASSASTADSRKAAPTGATEVGSNLAHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8M5</accession>
    <name>B7G8M5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkaline phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_39432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183369.1">
        <property type="nucleotide sequence ID" value="XM_002183333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8M5"/>
    <dbReference type="STRING" id="556484.B7G8M5"/>
    <dbReference type="PaxDb" id="2850-Phatr39432"/>
    <dbReference type="GeneID" id="7195149"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39432"/>
    <dbReference type="eggNOG" id="ENOG502QU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355082_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8M5"/>
    <dbReference type="OMA" id="LESNTHY"/>
    <dbReference type="OrthoDB" id="44589at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="86129" checksum="39B395D3F9DEDFC8" modified="2009-02-10" version="1">MKIPTVLSFLYVGNLLRDAHCSPLPELFAAKSMEEVEALMSKTKQRPAHEVLRGRRRLQDGTLETSNHILADRFGGEAGFFHSVASGDPLADAVIIWTRYTPVNVDDEITLEFRMAAIDPNLEVNAHLDPTLNENIKRGKVTVTAASDFTAKIDVTGLPSNTQFVYVFSDGQQVSDIGLTKTAPAPGDEDPDLIYAFFSCSHFTNGFFHAYDVASTIQDLDLWIHVGDYYYEYGLFDTYAREAAEQRDQFVLPIWETIDLQDYRNRHSTHVAHDEGLRNLRRRAPMIATWDDHETTNDSYGNVNQGTGAENHQETCLANATSPDADKAAAQCDRPEGDAVERFTAAAQAYWEWMPIRYVEGTMGEIQTGTLTQIIEWGDLATIASFDTRMSFRTEESTGASAFATYAAVGAVNTNVSSYSDPSSDAYAAIQQIRESDRGSRLNESFSMLGDYFDTLEDVFEASKAAGKPWQIWAANTMMGHYVLPDAAQFYLDAPEEVQAIIQTYFDAFMLSEAALTARLISALRVADIEWNLDDYGGFYAERAKITEMAKASTNNMVVLGGDLHDAFAWVLVEGGEVEGAPVAINLGCPSVTSPGFKNAFLPVFSPILEAIGGEDVAIDIMNRGYARANPNLKFSDIGKKGFVAIKATMDTHTAEYIGFSPETLLTDFATARTDGAITAPFECQISLTTQSDVPGSLEPSETCSAIAFDNERPAVYDLPVPSLDNMPEGDALTVCGMIGCAFDASTEPTDSASTVTPTAPAPAPASSSTLSIGRSMGLVTGVLLLIVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8T4</accession>
    <name>B7G8T4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Sar1B</name>
        <name evidence="16" type="ORF">PHATRDRAFT_15349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183525.1">
        <property type="nucleotide sequence ID" value="XM_002183489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8T4"/>
    <dbReference type="STRING" id="556484.B7G8T4"/>
    <dbReference type="PaxDb" id="2850-Phatr15349"/>
    <dbReference type="GeneID" id="7194978"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15349"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="B7G8T4"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC45225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="19712" checksum="CECE05A7C4705CE6" modified="2009-02-10" version="1" fragment="single">LGLSNKQGQLLLLGLDNAGKTTLLHRLRTGDIRHFPPTDRPSQEYFRYGNVSFQAWDLGGHEAVRHLWEDYVSTQVSAVFFMIDATDDGRVEEAAYELDALIGEQLVKDIPVAVLLNKCDEEERALTSADICRRIEYDNLAQTQGTDKMAVFRISVLKGEGYQDAFRWISNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8W9</accession>
    <name>B7G8W9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_39529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183665.1">
        <property type="nucleotide sequence ID" value="XM_002183629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8W9"/>
    <dbReference type="STRING" id="556484.B7G8W9"/>
    <dbReference type="PaxDb" id="2850-Phatr39529"/>
    <dbReference type="GeneID" id="7195353"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39529"/>
    <dbReference type="InParanoid" id="B7G8W9"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="14548" checksum="75517BC9DB70E4BD" modified="2009-02-10" version="1">MQSGAMYEFLFSYKSTQTLPGIPTSGVPRNWRGPLGAQEWAVRRTDRNQWEDGLVFLCTSPVTTFWRMAGMSYLQYVNKAATSMRGALKEPAQRKAMEQEAFAYKVSTWQDGKQSPKVPVDVLAQSGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9D2</accession>
    <name>B7G9D2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183754.1">
        <property type="nucleotide sequence ID" value="XM_002183718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9D2"/>
    <dbReference type="PaxDb" id="2850-Phatr49061"/>
    <dbReference type="GeneID" id="7195428"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49061"/>
    <dbReference type="HOGENOM" id="CLU_443780_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9D2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="125" mass="13746" checksum="A3EDAB22B72D2D48" modified="2009-02-10" version="1">MAEQHQAAPSEFQILSVLKQRISSPIFPKRSNTDKSKTEGSYEDFVSALMSQADPQPVLVIDTDDGGDAQNLCEIFRSSPPRNPSSGKAFTLVALVSIAKSTVKKKLVAMLEQARFPIFLPRSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN8</accession>
    <name>B7GAN8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_55046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184109.1">
        <property type="nucleotide sequence ID" value="XM_002184073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN8"/>
    <dbReference type="STRING" id="556484.B7GAN8"/>
    <dbReference type="PaxDb" id="2850-Phatr55046"/>
    <dbReference type="GeneID" id="7195817"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55046"/>
    <dbReference type="eggNOG" id="ENOG502S0IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620360_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAN8"/>
    <dbReference type="OrthoDB" id="2274046at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF5">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="406" mass="45028" checksum="53DDA5B0E9AA1CC8" modified="2009-02-10" version="1">MTTAALHANNPHAMRVATNTGPRPQLRRAVYIHVSDLTNAYNIDHARLEEELIRVQTNRDKPSEPSSSRFGVPTELDTSASQKRLQPPRGGYNLCVLVGKVEVVVDKYRVDGSRVRLAEVEVGDETGTVSLRARDEQIDGLTEVSQRAGAVVLRNCTLELYQGKHIRLAITKWGKLNSFPDQIASTPPPPSKMNHDRNFSLIDLSMVASEMASDPYRSTEADSHNSSIRQQSYPPAQPRRGQGRKSSTLKMQTGASVVSHHYPTSASAIPMPYSQGNLHGYGYTESMEPQPYTYHTRPHERMTSAQQQQLMMQQHYEMQQHQLQQMYQHASQGRQQMLSSQPIMIAPGLQATSSFDTVPETSPFLTSGHGAAASPKQQSQSNPTLRSDSPQSQGKMNPQAATYDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAQ8</accession>
    <name>B7GAQ8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_15922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184239.1">
        <property type="nucleotide sequence ID" value="XM_002184203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAQ8"/>
    <dbReference type="STRING" id="556484.B7GAQ8"/>
    <dbReference type="PaxDb" id="2850-Phatr15922"/>
    <dbReference type="GeneID" id="7195829"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15922"/>
    <dbReference type="HOGENOM" id="CLU_108953_3_1_1"/>
    <dbReference type="InParanoid" id="B7GAQ8"/>
    <dbReference type="OrthoDB" id="4717at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070930">
        <property type="term" value="P:trans-translation-dependent protein tagging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308:SF2">
        <property type="entry name" value="SSRA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="TMRNA-BINDING COMPONENT OF TRANS-TRANSLATION TAGGING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="Small protein B (SmpB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="11549" checksum="228A29C7CBFDFF87" modified="2009-02-10" version="1" fragment="single">RAYRNYEIVDAIEAGISLVGTEVKSIRNGKLNLRDSYIRPTKDEWSGILYNVHVHIGKHSQAGAFFQHEETRPRALLAHKAEARKLLQQPEQQGMTSVPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAZ5</accession>
    <name>B7GAZ5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glutamate synthase (ferredoxin)</fullName>
            <ecNumber evidence="19">1.4.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GltX</name>
        <name evidence="21" type="ORF">PHATRDRAFT_51214</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="18">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="19"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184279.1">
        <property type="nucleotide sequence ID" value="XM_002184243.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B7GAZ5">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAZ5"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="PaxDb" id="2850-Phatr51214"/>
    <dbReference type="GeneID" id="7195755"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_51214"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="InParanoid" id="B7GAZ5"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000061">
        <property type="entry name" value="Glutamate synthase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050711">
        <property type="entry name" value="ET-N_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938">
        <property type="entry name" value="FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938:SF133">
        <property type="entry name" value="GLUTAMATE SYNTHASE (NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="20">
        <location>
            <begin position="82"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEC44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1591" mass="174224" checksum="FD50EE845255BAB6" modified="2009-02-10" version="1">MISSACLVVRKGSRLSTFHRVSAVSLRRTLQRCTVPGITALQNPLLRQRFYSTERIVQLRSGRREDDLPKTLYDAKNEKENCGVGLIASLKSVPSRAIVERADEMLVRMAHRGGCGCDPASGDGSGMLFGMPDSFMRARAKELFQAELPAVGEYAVSNIFFPPGSHVNGKMDECKAILDRLVKESKHTTLGWRPVPVNNSQLGKDPLDSEPITQQLIVINDRKIPNKAFEQDLMKIRKMAEDEVAVIQGPESGFYVNSLTSHHITYKGQLTPEQVSQYYLDLQDPSFISHLALVHSRFSTNTFPSWERAQPIRMMCHNGEINTLRGNKNWMYSRGGIMESPIYGDDTSHLLPATSDNMSDSGNFDSVLELLTKGSNRTLPEAVMMMIPEAWQDNDNLSDKKKSFYEYNSAVMEPWDGPAMVAFTDGRYIGATLDRNGLRPSRYYVTKDDHVMLSSEIGVCPDIPDSDVKVKHRLEPGKMFLVDFETQRIVPDDEIKEQVASMHPYSDWVQNGMIDLESWSKQSGSRSGPMDFTQTNRKLNMFGYSSEKLEMLLLPMAVGGKEALGSMGNDAALAVLSEQPRQVNDYFKQLFAQVTNPPIDPIREEIVMSLVCPVGPEGNLLSDPQQSHCERLVVRHPVLTLDEMETLKNQEYKSTSGGQGFKTAVIDTTFSVGSGPDGMLQALERICDEAAEAIQGPFGGSGVEGVILSDKFAGPDRIALPSLLAVGAVHHHLLKTKQRPKAAIFAEAGDAKEVHDFATIFGYGCDAVCPYMAYEAICKMNEEGQIESKAKQQFTDEEAMQNYRKAAAKGLLKVMSKMGISTLQSYKGAQVFEAVGLADEVVDRCFSGTTTRIQGTDFEALYRDLERFHESAYPPIPSDLDDLVRSDGQFHYRDGGEAHLNTPAGMVNLQIAGRTNSREAYKEFARLTNEQNKKVTLRGQLKFKFDPTKAIPIEEVEPTSEIVKRFASGAMSLGSISREAHETLAVAMNSIGGRSNTGEGGEDPKRFLDNRRSSIKQVASGRFGVTSHYLANSDQIQIKMAQGAKPGEGGELPGFKVSEYIAENRHTTPGVGLISPPPHHDIYSIEDLAQLIHDLKNAQPKGEVSVKLVSEVGVGVVAAGVAKALADHITVSGHDGGTGAAAWTGVKGAGLPWELGLAETQQTLVLNGLRDRVKLQTDGQLKTGRDVAIAALLGAEEFGFATAPLVVMGCIMMRKCHLNTCPVGIATQDEELRRKFSGQPEHVMNYFFLLAEEVREIMAKLGYRNMAEMIGQTQHLDINKRGLHYKSRGLDLSPLLTPASELNPSAGIRNLTGQYHGLDIAKDIDFIAKAKDALENQIPVVIEDEIENVNRTLGTMLSYEISSRYGTEGLPDDTIHLKLKGHGGQSLAFTLAKGITMTVEGDANDYTGKGLSGGKLAVYPTADVVASGFEAEEHVVVGNVCLYGATSGKAFFRGKAGERFCVRNSGALAVVEGVGDHGCEYMTGGIMVSLGETGRNFAAGMSGGIAYIYDADGKFPARCNMGLVGLETIDTPEESEEVHSYIKEHVEMTGSSTGQKMLDNWENEVGRFVKVFPHDYKRVLMEREARAAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB36</accession>
    <name>B7GB36_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peroxisomal bifunctional enzyme</fullName>
            <ecNumber evidence="16">1.1.1.35</ecNumber>
            <ecNumber evidence="16">4.2.1.17</ecNumber>
            <ecNumber evidence="16">5.3.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FAO1</name>
        <name evidence="16" type="ORF">PHATRDRAFT_55069</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="16"/>
    <dbReference type="EC" id="4.2.1.17" evidence="16"/>
    <dbReference type="EC" id="5.3.3.8" evidence="16"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184394.1">
        <property type="nucleotide sequence ID" value="XM_002184358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB36"/>
    <dbReference type="STRING" id="556484.B7GB36"/>
    <dbReference type="PaxDb" id="2850-Phatr55069"/>
    <dbReference type="GeneID" id="7198195"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55069"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_16_3_1"/>
    <dbReference type="InParanoid" id="B7GB36"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000006">
        <property type="entry name" value="Peroxisomal bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309:SF49">
        <property type="entry name" value="PEROXISOMAL BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="332"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="514"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="656"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="767" mass="82191" checksum="CAC5DC8E9BA4032E" modified="2009-02-10" version="1">MTRSQVVSSSSQGLPTDTTAVICLADAAAGASPLHPLNAKLRLYLLQQLRAAEDNPAVTSLILTGGGPNFSAGADLTEFASLIPAAATTVPTPSDVGHHHPHAAPSLIDVVTAIEACRKPIVAAIDGVCLGGGCELALACHARVATARARLGLPEVHVGVIPGAGGTQRLPKLVGLRQALPMILQGSTVSAASALRMGLLDAIAPEATADSLRTTARQWAAYGEVLPTIRRTGDLQRPESPAEAHALLHVAELSLPPLGSHGMRAAIQALRASGTPIQHGMRRSPQGRARRHVFFATRRAQKVWSPVSNAVPTAGPPHGLWSKDDAQSAVPVAVVGAGTMGSGIALVLLQAGFHVTLVDVHAPALAKGMEFLKRTLASMVQRRQLKPTQLTALEAKLRATSNLQELSQCLLVVEAVVEKLIVKQSIFATLDKVTPPTALLLSNTSTLDIDAMASAVSSRRRGLFAGWHFFSPAHRMKLVEIVRGSATSDDTTALLQALTKQIGKIGVVVGNCDGFCGNRMLKPYSAETVLLLTETQTTVAAQDYAIRGVYGMALGPFEMADLAGNDVGYNIRVERQWARRARDDPLPPNRPARYTELPDVMISDYGRLGQKVGKGWYDYDSNIGKGRKPLPSSEMDALIRRYLAPKPSPALVAAEIIERVLYPLINEGFKCLEESIVRQPSDIDVVYVYGYGWPVWRGGPMYAADHEIGLPRLLRTLRELSKQFPTTEHYVPSALLVECVARKVTVEEYYQKNYHTASTGSAMLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB50</accession>
    <name>B7GB50_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184401.1">
        <property type="nucleotide sequence ID" value="XM_002184365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB50"/>
    <dbReference type="PaxDb" id="2850-Phatr49588"/>
    <dbReference type="GeneID" id="7198246"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49588"/>
    <dbReference type="eggNOG" id="ENOG502SS6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360002_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB50"/>
    <dbReference type="OrthoDB" id="48774at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052918">
        <property type="entry name" value="Motility_Chemotaxis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35580">
        <property type="entry name" value="CELL SURFACE GLYCOPROTEIN (S-LAYER PROTEIN)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35580:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="778" mass="83016" checksum="F3E4611D29460954" modified="2009-02-10" version="1">MKNFRLQRTILKSRYTNAREVAVILSLLVALPYCIFPLTVVSAQQTYTPAGIQSGPDVVGGSFASAAIFNPADNTVVVTGTTYGRFWQDRVDEADSSPGCFLVTARLPEVHHGDIAWVDSGKISTIAHKEGCSSIALRGSKLFLSGHADTGGVLEELRNSASIVPSTQYGMLLDMDYDGGSSRVDIVGGRVLQDSPVVFPVAVVALPGESEVYVASMATDSTVDHDYSNEQLDPQRFFPYGSKFHMTVSRLSLNGARFQEGTVLNTLDEQWTKPYSTKEAGDVYVAGMIKLSNEILVVVGSTTGYGGGVGGLVDTGPDMDGFVTKLHPVTGGVPVEPGNPKHQGTVRIQSVDGKDDFVAGVCHDEYRHDPGHIYIVGSTSGDLDRSGSAAAPRGYLMKLDFESLQPVWTKVLAANAATTTIANATSGGRPSVRGVSCVVTPDGEAVYAAGVVENSGVLPLSGTMTSFGGKDIYVVKYDTVDGKEGFVRQIGSSEDDEMAMRGGLLTDSQGNAVLVGHTAGSLYRTREESEKAGVSDIFLLTISRYDGKYQFPIEHPEYGQQVEEDVVSGPGSAPQTPEMSGTTMNAKAPSTTGSDSSGVLGLEKWTGLTILLVGIITSLLLVGLLLARRSNREVYTSRNQVLDYLHQFDVEDVDLKHSATGGWHCSYTNGLAHGINIRDGSSSSNDDIAAGPSQGVGLLPVRTGGFDPLTTPLNSSTLRDSLFVNDDSDGRLGRPDGHHSFGDDSSADRRHTAIHESRRSSTRKTRRKKLDAWGREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB63</accession>
    <name>B7GB63_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184409.1">
        <property type="nucleotide sequence ID" value="XM_002184373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB63"/>
    <dbReference type="PaxDb" id="2850-Phatr49600"/>
    <dbReference type="GeneID" id="7198251"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49600"/>
    <dbReference type="HOGENOM" id="CLU_706902_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB63"/>
    <dbReference type="OrthoDB" id="47277at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="734" mass="79427" checksum="26263930C7B51D0E" modified="2009-02-10" version="1">MSLSSSSPPARPSSPVSVPHRNDATSECEPTRGEEHVQAVVQKLIHVVTTQCQPQGRFWVTSATTTEVAATITPSVSTATTPSLETVSPPAAVPTISTEPLWTELDPLSVQQFVRDSLLASDSVRPVGIAAVPSPKATSGSPLFHINHNNEDNDDDDDNTKKRGRRPSLLRRSVSETMTPALDSKKKSTRTDARRSFRKSPAVSAEYDHLDNGAEHDHVHDHDADTTRRLPSAAPLHRRCRSAGPVTPTTHVGRMRRRPLVRVRNPLDVVFVTDGTSLVTNHTGNNRIRVLVDIKRTMYNNSTETERSKMVTDLIQVVTTHWRGRFLQQYVGDIDNQDANRQSPGSEYEVLDPHDAQQSQGLWAGPRSSSLDDDASSVTTNRSTVTSSTIATTATAAEKRVSEVKQEAVAAIHLLSPPAPDLHIQSMRNAAVESLQKRKKRQGLANRIRHLSAANIRGESLGTVDRSTSSASSVGSSNVSVTSHSRSTQSATATHDSAKPDRMPVSSMGPASASTHSVPMFADDQLLMTLESRLWAEGLRPEDLEPDPIAATTDVRRPSSTYEPANRNSSVLSNLSEGMVEMLMASLNEGGSYESDESDLSDQRSSTAYNPGPGQASQRPSSTFRSVDWEPRLPQTSSIENGAHNAGQASQRPPFVDSNESGIAPLRPSFVVSGGDDGGLLPLGNPGEDDNRFSGDGIESILSSLEVTSTPGRRRSSILEVHQEVDDEDDGEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB86</accession>
    <name>B7GB86_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_30486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184423.1">
        <property type="nucleotide sequence ID" value="XM_002184387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB86"/>
    <dbReference type="FunCoup" id="B7GB86">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GB86"/>
    <dbReference type="PaxDb" id="2850-Phatr30486"/>
    <dbReference type="GeneID" id="7198281"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30486"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="InParanoid" id="B7GB86"/>
    <dbReference type="OrthoDB" id="564720at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16994" checksum="D56C7C0013263CA3" modified="2009-02-10" version="1">MSSSLMQGPEFQHILRILNTNVEGKRNVVFGLTKIPGIGRRFSDLICKKAEVDVDKRAGELTADEIEKVVAVIQNPRQFKIPLWFLNRQKDFKTGKYSQVFAQNIAAKLRDDIERLKKIRAHRGLRHWWNIRVRGQHTCSTGRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBQ4</accession>
    <name>B7GBQ4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184486.1">
        <property type="nucleotide sequence ID" value="XM_002184450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBQ4"/>
    <dbReference type="PaxDb" id="2850-Phatr49735"/>
    <dbReference type="GeneID" id="7198429"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49735"/>
    <dbReference type="HOGENOM" id="CLU_884179_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBQ4"/>
    <dbReference type="OrthoDB" id="48019at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="35672" checksum="25E110C40E9EFE11" modified="2009-02-10" version="1">MLMIHMDRLTHQQHHHHPVDARHWETDSNTDDARSIKSASISGMLPLASDFKPGPYDVICARGKAAKNHVGNIQYRLNVERTLEQYSAASTKLEKSQIVSGIVDSIRESSRYGGFVKEEDGRWFEVGDHIAREKVGQSFRDMLHTKYRSSTRAKKKRRKEEQSKMGDDVDTFMLSHANVASKMKELSQTAQQRETDQSMEEMFNKANDQLLQVLKRESQHQQLNEAEHTPDGQTSPNLDPIPFAAVARRTQIHRPPEQAPYSYGRFGELAFLDDSLSESRPQVAESSLSHPHIDSAFSEFQAPQDFNRKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBU2</accession>
    <name>B7GBU2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184507.1">
        <property type="nucleotide sequence ID" value="XM_002184471.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBU2"/>
    <dbReference type="PaxDb" id="2850-Phatr49767"/>
    <dbReference type="GeneID" id="7198446"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49767"/>
    <dbReference type="eggNOG" id="KOG1776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223698_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBU2"/>
    <dbReference type="OrthoDB" id="49457at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19681">
        <property type="entry name" value="UBR-box_BIG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="1948"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="1948"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="2694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2694" mass="296876" checksum="8FD258C4B28CED51" modified="2009-02-10" version="1" fragment="single">MAKKKVPPAIGKGPASSTTITRVCVTRPSCLVLLTLPPVHRSRLTPMRRTTDPNAEDPSPPFDGVYDLLRSWRLRALEPTRAHSTDWTELGVLLSRDEPSGGSPHVTSPTTTPASSVASSKSPVRHTNTNAASGTVTLAYGLVLTTRVLEQLVQRRSDHDSSSLALVTVALADSLTSVLLRDVKALERLSHGPARAFVRRLWAVLTYALSHALQDLVPPDASPAEHDEHHTTATAVAIVTLEQLVYFQRGTNPFVLEATPASLWYRIARTVVVPNADRFWDDTDYWRRLCRSLLWRWTPTERAVWDVWRDLGRDSIPDRGPQRGADETLHGDDQASDGSTPRPDPDLARSPSRRATTTPHDSLAELVNTCWSRPEDGGRLPIKRWASVVLVWLTPGQEQLLRVGLQLLSPTRTTNPRNIPVFGTPPEYLPDSHSTPRTQIPVSTLRVVLVSRLVRLVHEMGTLAGARLPPNATALKAYVTGLQGETMPKPKKGSQKIKATKPDLRDLGTLLSYRILQAHDACLATGWADPTVTLINDDVAVAHPVVWYYPFVSHTLDKLSHAACASVPNTGHAEQNLWRNRMQHMAAGWIWARHRSRPEGPVDAKLMAFCVGRLSSALTLLDVDPSGCEPDSSSREWNLTQALSEPVLGVPTKTTNRKRKATTGTGTETTRAPRATKNTCTFAHTFDVVERAVFGGEEMLSLVFRAFAEEPSKEKVAESILSSLISLVEKCYDLTEVEALLTDLPTGKKRKIPKASTAKRKRRKKDDSTAEVRVDCLPTSDGSYGKGITQARADLAGDCLEALQMCVKDPSAASTFLLALLRNAVSVDSIERVVYLGSRIEGIMVRPDRANNPPNADTLKREPNDSGEGSSPWTSREKKLWSSHMTLVLMLGSGGRANSSAPKRYIFGANRLQIFKTIAAQTSTILSGPFSEAGWPIWQPRAHRLLIASNITNELSTPSRENTAPDCYIVAGMIDSISYLLRNILKFVNLPARQDEWTIEEEIPLSLSDARLFLSVVARLSPQEQRSSLASLLKEMDKAVHEFRKSEKLLAFISGDRKASGFLARLIVLATHFALSVMSGKRFQGVIVNVLEKSLSLSAPIPATGWYKAETCFMGVFLDWESSELPEVPTSLWGIEASTGRILQGVLEGFFKIGILTAPQDNCHLLFASWNALGKSPLWTERTPGIQIPSVLPRDPALLLLDLREDICWLHGQLMKLEGSPCGSTLMEAIDSRVSGDSNQSAAKIKDLLTMMVSKATYVVDKICDQYIPNSAEMDFPMASSVHPLLEVVSCYLSFAVSSCTKPHNQFLSTIQAEVSGGKRARGYSSGSDNLDFDVESGDSRGGLEALERLRNGCLAFGAAPVHPDWLDDECRFRDEFSESDIVKIAIQAQTTLRKIVVLAQSQLEVSLRTVFSRTGESSDNVRSDLAFKLCSLHRFLENQPKDSSFSFQEESVKFEIGSASNLSNEVIGFLLMHGLRNSRVRTKKWYPSMVQRVPGKVHKYFRHKVKVDVSTPELRVAGEWEVLAGLALTAFSTPLCPLQDQAHGIEKPVFREIALYEKWHEVGVAALSSLAPVVSLLRMGLQHSGRPTHPFAKTKATFEDLDVHTLCPKSWTLSHSMLDEPQKNSILDTLGVLARLPVNSTWEAVSCQLVLDGPKFRTIQQFEVVRLALAAMSALASAANGNAIDRPDIVRKLMDRVVNILIQHVGHDRAGFFFESIGVKEVDYRTIVGKTSTISKRIDETRSMCCLSKELVDGMFLFFLNETEAVSQEARLSILCLMSSIAQHSLSNDCSTKSKALEVVGLFREAFYAVPESRILSLVTSDICNHSIEGSDTLQSAVSCILAFCLIELEKPGAYAPIIESLKDFVDDSMNKDYRFVSRPLLLLLLCSVQWDCLHDVVGTLLESNASQSRQVIKIVATFLESLNNDRSTVGSSRVKSDANDVTGKPVICSFVAKAGFHDQHWYNCYTCGLTWDKGCCSMCALVCHMGHDVAYSRYSSFFCDCGGNNKREAQRKCRCLTPLPSSEAEAAWAFGNARGGGKGTWTPRSPDLRPYKLDSQIDAQTNRFGEIALQFCPSQVKSALGSIINVGRTRNWGRITLDAVYEEYRIRKDDSSVMLLEENEEEQMNWCQEGGDLLSRRTNTQVVFKTDPSLPFRVARQSESGVFELSKKVDLPLDETGKALRDTKPSVRSALEVDSRGNVVVAATRVLSFWNCVQLLNTRYMHGGTSFSRTSLSIEGSRLVDFDIHGMKLSRPNENFLLIWGLSDVTVYSWKAAVNTCETIFDLSQQKKSLATADDEVVVHCDWLPGSMFAIAIVRSRSINLFHILSHSKMSTPVATISVSQKNASISNCCFIPITHSSDEAHSMSWIIMAILDDGRVCKASVTMNDSASVFSVAPEFDFARYLPVPDREDDTTERGGPAGYRKNMIGRQLDFLPLSRLLLLEIPSVCVMAYAVTEDGQISRGFELVPWEIRGKASVRGPFTRWRDFGRDLKCSSTKFCVGCICESSSSGDPVPLVLGVDGTVTSVATIQGAATLGSNGTSVEGIGLFSVPELIDDCAIYDLRGRRSFRESIIWLILSSNGSLCLLKEDGGWPIATQLNSQNERRTAIQTSTASAHLDLPMKLIASPLLAFEELTNLTDLKVVEFAGFGLEAGDILKSKLTKDNDSVLASPCRDGFTLSLSVRSESSKMLDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCD0</accession>
    <name>B7GCD0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184785.1">
        <property type="nucleotide sequence ID" value="XM_002184749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCD0"/>
    <dbReference type="PaxDb" id="2850-Phatr49934"/>
    <dbReference type="GeneID" id="7198631"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49934"/>
    <dbReference type="eggNOG" id="ENOG502SNEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579356_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCD0"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47823:SF9">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47823">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="54960" checksum="6B13AC4804BAD487" modified="2009-02-10" version="1">MAESPSRHPRNAGVAYQTRSGRSVQPPLRWEDECDHHDSPRGTVVGQSASQRSTETCCGSKPVFVVDAVPSPTRVYTPRFGATMDTSSWNSRPYFSVESLPSSSSLNQLLFPENHCTHNSNNNYNISKVNTDTLPHTLRRRRRVLFLEEKEVYGHDVDEYDNESFQDAYQMQASPLRRFAIRPRQRVQRIRKALRGRLRPHRASHAIKSPWLVSADHPVKILWDVLTVVLSLVNAYLTHAAIRDRAFNDNLFVRFCECWFVLDIVLNFLTEHKTSDGLVYNTVQAVWARYLTTWFVVDVLSLFPGEALYVRPIIERQNRRTWWQKSFFRTKAVIRVTKVLRSRHVRLFGSVAKRTKHAGVGAHRLLRLVIKYVPKYVLFLKHMRAVIALRVLRQVHWMRKVWRNVTAIHSVKPLFPDDDDTLSLTEGFDDPVYEDYNEDGDDLASLNDHRQHISPSNRNDWEWMDDVDDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCY0</accession>
    <name>B7GCY0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RRP</name>
        <name evidence="8" type="ORF">PHATRDRAFT_55141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185033.1">
        <property type="nucleotide sequence ID" value="XM_002184997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCY0"/>
    <dbReference type="FunCoup" id="B7GCY0">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCY0"/>
    <dbReference type="PaxDb" id="2850-Phatr55141"/>
    <dbReference type="GeneID" id="7198906"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55141"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784064_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCY0"/>
    <dbReference type="OMA" id="FIREGCH"/>
    <dbReference type="OrthoDB" id="49027at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="82"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="354" mass="38064" checksum="444EBE586F7ADEEA" modified="2009-02-10" version="1">MDDSTPLLSRSEMDFIREGCHQNCRVDGRGRDEYRGYRIVTEGSMSHEDNSSTSNPPLILSNGSARLFEAARHAHEDVSLHMLCSVKAEVVHPSALHPAQGAMELHVESLTSSGPNSQRRKTQDELEATLSKLLMRDLVDLEALCIVPYHYVWRLHVDLFVLTAGSSHGSLCDAASHVIRAALQCTRLPAITSSTATANESHNGLAKASFRNKNPLFPHGGVELMVDGDLAVASPPPGVNQAPIIVSVTVLANSEVLRRTPVSAVSVAPVLILDATPDEEACAVAQVHVAIDRSDGSNPLITALHQSRQGSLPLNVLTDVCAIALQGAMSAEAAYVIRPGRNDLGLLQEQFLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD28</accession>
    <name>B7GD28_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHATRDRAFT_50135</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184976.1">
        <property type="nucleotide sequence ID" value="XM_002184940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD28"/>
    <dbReference type="STRING" id="556484.B7GD28"/>
    <dbReference type="PaxDb" id="2850-Phatr50135"/>
    <dbReference type="GeneID" id="7198933"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50135"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_2_1"/>
    <dbReference type="InParanoid" id="B7GD28"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="114"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="498"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEC43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="626" mass="70420" checksum="DAABA83CA359F06A" modified="2009-02-10" version="1">MATMAAANVITGQFDDADSDEEDFVARMQAQRQPATLPVQSSKLACVSSFTRPPVESLQTYYDWDDAPLTSVAAQSVAQASAASSKQMNLSHAVSNRVTQMEHLETHKRTLTQGRDDRATSEQVLDPRTRLILFKLLSRGFLEAIDGCLSTGKEANVYYAKAGKHHLQPQRYDATPTPTDEDNCDNTKPRHVTEYAIKIYKTSILVFKDRDKYVAGEHRWRKGYCKSNPRKMVKVWAEKEMRNYRRIYAAGIPCPEPILLKAHVLVMEFLGVGGWPSPRLKDAALSDKRLREAYVQCVLIMRHLYQRCKLVHGDLSEYNLLWHENQIYVIDVSQSVETDHPSALDFLRKDASNVNDYFRKVGRLNVMTVRQLFEFVTASVLPCDQPNVATEQAELASLDAIMQHVDQTALQLAETSEQGQRKVEQQEAVDEAVFMSSFLPRSLNQVAEHEIQKLATGEVEDTYAQAVASLTGNRDVVEAVAKKLGRNDFMTKSVQSILTNASSRESPQEEERKAGGKNGVHFSAVLDEKGDKSPSRQSGEDEFMSECDDDSSVDSEGESVDKEIGFVKTPMTPEEFTAMKEAVRTERRANKKAVKDAKSEQRQNKVKKKDKKRAIKKSKAGNRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDA7</accession>
    <name>B7GDA7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_16648</name>
        <name evidence="8" type="ORF">PHATRDRAFT_bd295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176159.1">
        <property type="nucleotide sequence ID" value="XM_002176123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185021.1">
        <property type="nucleotide sequence ID" value="XM_002184985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDA7"/>
    <dbReference type="FunCoup" id="B7GDA7">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GDA7"/>
    <dbReference type="PaxDb" id="2850-Phatr16648"/>
    <dbReference type="GeneID" id="7198879"/>
    <dbReference type="GeneID" id="7205044"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16648"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd295"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898533_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDA7"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12189" checksum="0381D6F638D81072" modified="2009-02-10" version="1" fragment="single">RKVGLTLLASGIMVTMLGISLFFNKTLMRLGNLLFIAGVPVTLGPSRTMGYFLQPQKTRATVCLVLGILLVFFGHPVFGMVLEAFGLLNLFGNMFPLLMAVVKQMPIVGNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDC9</accession>
    <name>B7GDC9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185107.1">
        <property type="nucleotide sequence ID" value="XM_002185071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDC9"/>
    <dbReference type="STRING" id="556484.B7GDC9"/>
    <dbReference type="PaxDb" id="2850-Phatr50221"/>
    <dbReference type="GeneID" id="7199086"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50221"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373202_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDC9"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84005" checksum="448163A240BE56B0" modified="2009-02-10" version="1">MKYFLFGARLGRTSSFLAKSEIYESLPLTFGTLVGKPFRCNMSKIDDTTQERFTPYCASIRRNPEKSVGEQLVLPKCKMPTRAEIEPVELFVASAVQQQYESGDGTNPTENYSALIDPFLVRKDLAMIHRILLALRTSGHGATLNRLASSARHARLIHHIIRLNPFRLPCPAESQSSMDDYVDYDIADAQLHLMMALVSANSVFMIPILTSLWSMLSFESVDAPFEQTQRLHAAMATIVRLCPKAKKVVRYVPAMEAQVLEFLIEKSLEMDVEIKIDEGGEAEIDTDYSVFQLDMDSDAHSLRRRQLNEVNVQESIVNDMAEKLDSLMFLLLEYVEQSCAGNADLIREKYRILAQFFESSIIITHKSKFVQFLIVHVCGLENKALESASCQNDQSPAILYRKFASSLIHVIVDPYRATVTRQAAACYLASFVSRASFVCEETCCESVCALLRWGEAYMQSLDSLSVHAADAREQCNFHSLFYTISQAAFYIMCFRGVEAIEFYRKSTKPSSDGFAQPEHLDISPERWTSLCSHPLQPLRYCLESVRNEFLELSKFCHLINAIVYCQLAQDENNVVKRNKRQVTPIATPATLEKERLSGGVGGLGKGTNPLDSFFPFDPYLLRKSHVFVDPFYNHWNGSITERFMKDEDSVLNPSDEQHVDDDESDNKKGSIADGVSHDDFDNEIVTKSFQPMSLGSEFGPASASSRSTVSTESSSNVPFKRDSSREPWTDTMKRSRAPSMENGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDF6</accession>
    <name>B7GDF6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185203.1">
        <property type="nucleotide sequence ID" value="XM_002185167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDF6"/>
    <dbReference type="PaxDb" id="2850-Phatr50245"/>
    <dbReference type="GeneID" id="7199019"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50245"/>
    <dbReference type="eggNOG" id="ENOG502RY2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047646_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDF6"/>
    <dbReference type="OMA" id="RQMYNDI"/>
    <dbReference type="OrthoDB" id="44735at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853251" description="Lon N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52329" checksum="286FD825D5E69BD5" modified="2009-02-10" version="1">MKFSREALLFLSTVTISFSSFTEAFVSWDGRTTTFLSNRWSHSYVTWAATNFGPTPTRTKHSRLRMIEDDVDDDEEDFDEDAAEPLSKGVRSVSWLPTVANAKGDGVPELTRKDSEILPLFPLGGIVYTPNSEHILNIFEPRYRQMYNDILMNGTKRFVVSMSHPSESGRFAQTGVLFELEDLKEVSEQTADQIKYICNHKVTGRVKLHRVLNPEAWQSRDTYLRVEGTITDDSVKEGESASSSIYGVVGNAKEEKALKSAFSDLIEIQHELEEDVRFTRASGMTLSVKPGSGEDGLWQTIRLWQSFADQRLMARQNELQRDFQEKLQAFLKKERGLTEEELPSAIGFDDLSPALQVEVQELQKRMAIELRPLVLESTLTMQKVLEAENHTERLQLVRHFVEAETRRLTTKKTLRGVFSGSSMGTGEGSDQSEKRLTESKRKNENSSKPSSIFTDEDDAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE78</accession>
    <name>B7GE78_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185390.1">
        <property type="nucleotide sequence ID" value="XM_002185354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE78"/>
    <dbReference type="PaxDb" id="2850-Phatr50473"/>
    <dbReference type="GeneID" id="7199317"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50473"/>
    <dbReference type="HOGENOM" id="CLU_584589_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE78"/>
    <dbReference type="OrthoDB" id="49643at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="459" mass="50218" checksum="56E4BBDFC23B6429" modified="2009-02-10" version="1">MANSSVGAPSSRDACSQRLPHPSSFLSTTTGRKSTKSGVAKAQEAIVLSQATSQAIVAARSILESGGSEATALSTAKAAAQSILIPFLSDTEHGASKLFLGRRKAKRQADIIASMAILSVTNGSNESEGSAVRDNEAPTFMQHRIGPSGLPGYSCSRKKHPSHCESSVRRGDNNSTLRIKPKHSYPPDRERPYCKEKARHGAGFLNSRRGHVKDAGRSHPNDLAARYPDQDPIYCSPSHKSTLAKQRNKFPSYSSETDDETRSRILGIRGSGSADYIVYGSGTIDTTDQPVHTSTLMTIWWTRIPIKEDRDQDDTFRHESVNERVESSSSANANDVLRKLVSSSSDEKGRKETSIKPRIRESIEQTVLRALSGGVVPPQWGAEAVGIVADAPSDRIFQSRAIREEDLFTGVQPSEPPSPFTATYSRSKMLSHKPRFRKWVTMRKKSKDNHENAIVAFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEF9</accession>
    <name>B7GEF9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185481.1">
        <property type="nucleotide sequence ID" value="XM_002185445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEF9"/>
    <dbReference type="PaxDb" id="2850-Phatr41522"/>
    <dbReference type="GeneID" id="7199379"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41522"/>
    <dbReference type="eggNOG" id="ENOG502R1WQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120168_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEF9"/>
    <dbReference type="OMA" id="ESGQDEW"/>
    <dbReference type="OrthoDB" id="197165at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045388">
        <property type="entry name" value="HHL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20133">
        <property type="entry name" value="HHL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855824" evidence="2">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="182" mass="19521" checksum="36D9CE7B300BB753" modified="2009-02-10" version="1">MRVVIGVTLLAVAVSSFSSAPTFRAGSTRTVLSATKGFGAGPEPKKAKSEGQVKREKESSKYDEIAGTGGQEYSIFVRQFGSDDQSWLPCGSVAVPRNAQVSDAVYANDEALRKAIVRTYPKLRGSEEEFEFGYNLKVYPDDPIEVAVKGKPRPGGLSVGNWISTLLSPVDASKVPPPPIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEI9</accession>
    <name>B7GEI9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185532.1">
        <property type="nucleotide sequence ID" value="XM_002185496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEI9"/>
    <dbReference type="PaxDb" id="2850-Phatr50571"/>
    <dbReference type="GeneID" id="7199359"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50571"/>
    <dbReference type="eggNOG" id="ENOG502S635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802845_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEI9"/>
    <dbReference type="OMA" id="PRNAINM"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474:SF1">
        <property type="entry name" value="2'-5' RNA LIGASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474">
        <property type="entry name" value="RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="346" mass="39702" checksum="F8691AE966673ECD" modified="2009-02-10" version="1">MATEAHPYYKKLHHLTVCMVPHDEDRRVWEQLTKVRTQLRDPGLYRWPPHANLLYPFLDIRPTPESGDTTPRNAINMDIVDGLKRVCHLYDPFTVRLEKFGTFGGSKRGVLWIYPDSRPRGNGGDEAHDAEPLVALQASLEAQFPMCMDQRKTGAFSPHITVSHFADLKCAREAQALVETEWPTDLSFQVREVYLMQRLGDDGQFERVATIGLAGHETIVHRQPLRFANMPESEEEWVRRERMAMKDRRNKGSRGHRRQRESIRTGRPSRVKDSPVVIEAKRAMREAKREMLLAENNGEPPETAKIHEAIFRAKEEELRAFQNLQGQAQSEKQVTSTPATNESTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3J1</accession>
    <name>B7S3J1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999253">
        <property type="protein sequence ID" value="EEC42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176134.1">
        <property type="nucleotide sequence ID" value="XM_002176098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3J1"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft315"/>
    <dbReference type="GeneID" id="7204850"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd315"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_1_1"/>
    <dbReference type="InParanoid" id="B7S3J1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF22">
        <property type="entry name" value="OS07G0227800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="118"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="497" mass="55007" checksum="D1DBF6EE1802F5ED" modified="2009-02-10" version="1">MAFSENGGSGSRRVQKSVRDRTQEETFSLIKDVLRAAVDAGPRAGPARTMQAYRAFATTAQEFLPKLAQGPETISPAAVLRTLFERMGATYIKLGQFIASSPTIFPREYVLEFQKCLDQTESLPWPIIKKVIEDELGPISKNFQYVNSKPLASASIAQVHVARLRTGEDVVLKVQKPRIDESLKADLGFIYVAARILEFFLPDWERTSLAAIAGDIRSSMLEELDFEKEAQNTIEFRRFIQDKGLTKQATAPFVYPAFTTKKVLTMERLNGVSLLDENTMGKVTKNPQMGTDVIITALNIWSLSVTAMPWFHADVHAGNLLLLNDGRVGFIDFGIVGRISEKVFRSVNELSAALVVGDSEGMAIALCNMGAAGKDVDTNQFGKDIQRVLDRMNTVQPEMTVTAHQDGILQGQLNVDEGEGTDLLLELVEVTEKNGLKLPREFGLLVKQSLYFDRYLKILAPNVDVMNDSRVMIGGTKREESDSVNGSEFTDTVVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7S430</accession>
    <name>B7S430_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_bd1667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176326.1">
        <property type="nucleotide sequence ID" value="XM_002176290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S430"/>
    <dbReference type="STRING" id="556484.B7S430"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1667"/>
    <dbReference type="GeneID" id="7204795"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1667"/>
    <dbReference type="eggNOG" id="ENOG502SG8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623302_0_0_1"/>
    <dbReference type="InParanoid" id="B7S430"/>
    <dbReference type="OrthoDB" id="49348at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="386" mass="43118" checksum="ACE96ABB17044A32" modified="2009-02-10" version="1">MTSHRKRPNFQHGQQEPITDDLVVAAQFAAAFRSTAAEKSNEEWTPEDENEIGLTSSEGERDVDDEEVTPLDKSAPESEKIEGWNDDTVDGDAEDESDDESEVDLGEELARMDKDADGDEVTGTSHCPKTPNEIDAYHTSVYHLESKLKMKLAVEEQDRLRLKTVQSINLKPAGRIQHHMTDERTVVVQSQSSLVLQEGNLLVLQLPECGTVPLGKIFEVFGPVSQPLYSIRLPEPLVNMEEDEGINKLTPIIGKTEEITESEKILDEGDPWSEDGKYTRILEKIPLLNVYYVQNEAELIDPEAISKMSGRGCDASNLHDEEVVNPNDMYFSDDEEERQAKGKGRKGTRKGHNPQHSSEPRALRSCPSAPQGFHFALTAYTLFATI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0I1</accession>
    <name>RK2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL2c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">50S ribosomal protein L2, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpl2</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874456.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0I1"/>
    <dbReference type="SMR" id="A0T0I1"/>
    <dbReference type="FunCoup" id="A0T0I1">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="556484.A0T0I1"/>
    <dbReference type="GeneID" id="4524658"/>
    <dbReference type="InParanoid" id="A0T0I1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000003">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_uL2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000277104" description="Large ribosomal subunit protein uL2c">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="275" mass="30722" checksum="D94BFDF8C7EC5220" modified="2007-01-09" version="1">MSIRLYKSYTPGTRNRALSVFDELTKTTPEKSLIRKNHRNKGRNNRGIITVRHRGGGHKRRYRLIDFKRNKYGVEGVIASIEYDPNRNARIALVNYTDGEKRYILQPKNLTVGDRILSGSGSPLNIGNTLPLNEIPLGSSIHNIELIPNRGGQIVRAGGTSAKILAKDGDYITLRLPSKEIRLVRKECFATIGEVSNNDAFLVQSGKAGRTRWLGKRPTVRGSVMNPCDHPHGGGEGRAPIGRTRPLTPWGKPALGMKTRKRKKLSDAYILRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3U1</accession>
    <name>B5Y3U1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_36843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185716.1">
        <property type="nucleotide sequence ID" value="XM_002185680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3U1"/>
    <dbReference type="PaxDb" id="2850-Phatr36843"/>
    <dbReference type="GeneID" id="7204549"/>
    <dbReference type="KEGG" id="pti:PHATR_36843"/>
    <dbReference type="eggNOG" id="ENOG502T9X5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691629_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3U1"/>
    <dbReference type="OrthoDB" id="48310at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="399" mass="44272" checksum="928F6BC9AFDA3323" modified="2008-11-25" version="1">MTADTTQKRSKRNQQGYESKNNNYNNNKMSTTYSSVGGTAVKRIRVPHPNDVLSGRGGGINSHVGNVRFREWVAVRKNDYTLAPSKADKARVAKEVIDLVEHQTPPGRFLQKDPTAVGGAGWWVEIDEERVMAKTSQALREGAPQIRALHRDELDERKSNYDRRRKADAKPESSGKNNKRSLEEMRSAASSPATTTPVSNSISRMHEQAVNELRANAEAAREAKQVRLEYGGNVVLPSEETPPLTSTKIEDNDAMVLPPPLDLDCVPAPHKNMKRTHSLALSDLGNTDDWCATDFVNPFEDEYEAQEFSWTPPSPRPGILRESSTSNNSDMGGIGALMRSDSSRSNTSSSNHNTSNNGVRPKNTVANMSNRYGKDSKHKDEITPLDEWWDVDSYVPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3V3</accession>
    <name>B5Y3V3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATR_21116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185721.1">
        <property type="nucleotide sequence ID" value="XM_002185685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3V3"/>
    <dbReference type="STRING" id="556484.B5Y3V3"/>
    <dbReference type="PaxDb" id="2850-Phatr21116"/>
    <dbReference type="GeneID" id="7204556"/>
    <dbReference type="KEGG" id="pti:PHATR_21116"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="InParanoid" id="B5Y3V3"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.470">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="12">
        <location>
            <begin position="181"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACI65191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="418" mass="46312" checksum="2E236AF3B6677D68" modified="2008-11-25" version="1">MTDAKPKLLLAYSGGLDTSVILKWLSEKGFDVIAFCANVGQHEEDFSAVKAKAESCGATKCVISDLRKEFVDDYVLEAIKCNAIYEGRYLLGTSIARPCIAKEMIRIAHEEGATFIAHGATGKGNDQVRFEMCCQALSPTIQCVAPWRDAEFIESFKGRKDLLAYCNQHQIPVDAKPKANYSIDENLFHTSYESGMLEDAMCPPDESMFKMTVSPQAAPDLPETIRIEFDQGLPVKLTNVTDGTEITDSLELFLYCNTIAGKHGIGRIDIVENRFVGIKSRGVYETPGGTLLRAAHMDLEGITMDREVKRIAEHLSAEFARLCYNGFWFAPEMDLVRYSLDFTQRDVVGVVELELYKGNVTIRGRQSPKALYNADLASMDIEGGGDAFDYNPADANGFIRINAVRLKTYAALRAKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5B7</accession>
    <name>B5Y5B7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATR_54187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186158.1">
        <property type="nucleotide sequence ID" value="XM_002186122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5B7"/>
    <dbReference type="PaxDb" id="2850-Phatr54187"/>
    <dbReference type="GeneID" id="7203863"/>
    <dbReference type="KEGG" id="pti:PHATR_54187"/>
    <dbReference type="eggNOG" id="ENOG502R686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319232_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5B7"/>
    <dbReference type="OrthoDB" id="48232at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41394">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MGTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41394:SF5">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="764"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="911" mass="98308" checksum="ADC493A50DDC650B" modified="2008-11-25" version="1">MSASDEEDRKPAAIEHHSFVEDDEDNWSRRVENDETATGHLLHAEDSYLRMESPRQEICYDPSPLAAVLPPSQPELTMKEKLVLRERQRRIETERARLKQQFALRHHSASETSSVEEDDDHHGDTAGGRSATMAAFQENGSVAGTLGEESTIAHPDEETAALEKLGFNMERFLRNSDNFKPQAESNNSLLPLAETEGGVVMERFLSNPVVVEADDGDRESTSGHDDTEGLTTDVQRSVSFDVDASHPNGDGVIPTSMSAFPDGANVSLQAESHIDAQRRHMITSATLTGIPSAPRSMDAEVASDGNLTDVHSQTSSTRTADEFRVMRLTEADMREMEAIDEVSIGNAPPSEREEELLSEVGELADFRGGFAGAAGNYSQGTRTTAMESASLISGGIPSDKQASEDHTRDHSQEHREHYEVVDTQATEIADKHSLDGMTPGSMSSHLMVSPGASAAGSTLAQPSNAGVLDESIDGTMARLSVQPKFDDKDVSSDMASVPASLRNSADDLTAHAGNESILNRRVRPGMPGLKPAPQNLEANRKESSTSVNAASGPPIVVDDFDYDINAPETPRSTNDEMQDSFLNSPDGPPLWTLEENMIVSPVQQSRSGSTPVDSLPASQIYGSMTTGRAIPAQNGSAEESAPLLSVPPEIITMRERSEMSSLQNVAAHVKHQTSLSSSQNDHTRHESVFETLRAEEEHVKEEEQTESELYNTSNVLARAFPERLMALIVTLILEIPVLLMISGGSDNLCFLIGRRRYHLLVGFIPLTSAISGNVGLQSSTLTTRAISHFHVTESSFIPWLMREIGAAACLGCGMGIIMGIIAFIASEMDLAFGVTIFIAQIISILTAGLTGTLAPLLFSFIFRKDSGKWGGPLETAVQDIVGSFAMIVISFHLLAFLGPGEIDAGDTCGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5F2</accession>
    <name>B5Y5F2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_10508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186176.1">
        <property type="nucleotide sequence ID" value="XM_002186140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5F2"/>
    <dbReference type="PaxDb" id="2850-Phatr10508"/>
    <dbReference type="GeneID" id="7204047"/>
    <dbReference type="KEGG" id="pti:PHATR_10508"/>
    <dbReference type="eggNOG" id="ENOG502QS0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766102_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5F2"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF41">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY (PH) AND LIPID-BINDING START DOMAINS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="225" mass="25539" checksum="7B144E7A27557A9A" modified="2008-11-25" version="1" fragment="single">AWSETPAAKFKVRGTKYLQDRIKVPSEASAFHLLCVDLVKVNQPIFTGLCSHPNERIQRALAKERETGLRILPDFVFAVNLCVPGKSYYHWVAYFGVDDIQMIKTQETPLGRVANPFFFGPSDEFRSKVFKLIPRIVEGNFVVKKAVGSKPSILGRKLKQYYIQNERFMELIVDIGSDCMAQRIVKLALGYAKTLEVDMMFLLEGVHPSMLPERILGGVRMINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5G3</accession>
    <name>B5Y5G3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186180.1">
        <property type="nucleotide sequence ID" value="XM_002186144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5G3"/>
    <dbReference type="PaxDb" id="2850-Phatr33498"/>
    <dbReference type="GeneID" id="7203887"/>
    <dbReference type="KEGG" id="pti:PHATR_33498"/>
    <dbReference type="eggNOG" id="ENOG502SCEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329694_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5G3"/>
    <dbReference type="OrthoDB" id="198528at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="187" mass="20022" checksum="35B2179B91CEAA8F" modified="2008-11-25" version="1">MNTFVAVSNSGDGNRVMTSPDGDIWTSRESASNNWWSSVAFGMGTFVAVAKTGFGNRVMTSTNGIDWESQTSVPNHEWNCVTYGGDLFVAVATNRIMTSPDSVSWTLRTSPNFKAWSSVTYGDGVFVAVAEALGDEAMYSRDGINWRTGSTAKGYAWSSVTFGDGMFVAVSSTEAMDNVMTGMESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5R2</accession>
    <name>B5Y5R2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RabX2</name>
        <name evidence="5" type="ORF">PHATR_44216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186509.1">
        <property type="nucleotide sequence ID" value="XM_002186473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5R2"/>
    <dbReference type="STRING" id="556484.B5Y5R2"/>
    <dbReference type="PaxDb" id="2850-Phatr44216"/>
    <dbReference type="GeneID" id="7204127"/>
    <dbReference type="KEGG" id="pti:PHATR_44216"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="B5Y5R2"/>
    <dbReference type="OMA" id="QMLDTPH"/>
    <dbReference type="OrthoDB" id="193217at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="229" mass="24482" checksum="57F25017C53B70E2" modified="2008-11-25" version="1">MSNRATGGAGKPPLYKIVMLGDSGVGKTSLVARLTNPDRPLNHDISATMGIEFDTQMLDTPHGKVKAQIWDTAGQERFARVLLPTYFRKAKGVILVYDITNAKSFESLAERWMAQLQDHASTDDLAKLLVGNKSDLEASREVSQEKAQQFCQEYGMEMLETSAKSGENVLTSFERLIGIVHDRALTSQKSRGGIAGLGGPSGGTSSATPATVNLDETKGANTDSAACGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNV3</accession>
    <name>B7FNV3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_42595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177103.1">
        <property type="nucleotide sequence ID" value="XM_002177067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNV3"/>
    <dbReference type="STRING" id="556484.B7FNV3"/>
    <dbReference type="PaxDb" id="2850-Phatr42595"/>
    <dbReference type="GeneID" id="7196282"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42595"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_481901_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNV3"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JmjC" evidence="11">
        <location>
            <begin position="175"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="476" mass="53855" checksum="EAC9D08728E42171" modified="2009-02-10" version="1">MSQNEALDEAHHANRHVAEFLALPKSALLLSPASETIVQLVEDGSALTAANLLNDHSVLTIQRPILVTDSPESIGMKLPRTKNGRDVTISDIARYVGSNMPVRVIDVKYQHELEGWTFGDLVDYFEDEDRTKGLRKSNDIEDVMKKRTSRPRRRAAQKCIEKTGPGVLNQISLEFSDTPLAHHVRSPKFSRELDWIDNVWPKRLKSENIYPNVKYYCLTSASGSYTDFHIDFGGTSVWYHVLSGRKDFCLIAPTEDNLKVYEEWLCSKSQTELFLPNQIRDSRSISRIHLNKGQTLFIPSGWIHAVYTPDDSLVFGGNFIHGIDIDMQLKVYSIEIRTKVLEQYRFPYFVPLYFYAGGYYLRKSRIVTIASQELKGLPVLVDALVGWWNVWKNQDVDDSALTVSTVKAARESALASNCDSVEELLSELHAAFGSRFSHISNADEKGSNNTASVRDRQQKPTLLTMLSELRSSLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP31</accession>
    <name>B7FP31_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_9197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176638.1">
        <property type="nucleotide sequence ID" value="XM_002176602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP31"/>
    <dbReference type="FunCoup" id="B7FP31">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FP31"/>
    <dbReference type="PaxDb" id="2850-Phatr9197"/>
    <dbReference type="GeneID" id="7196006"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9197"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="InParanoid" id="B7FP31"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="64" mass="7304" checksum="4CCB4C8D79ACE27F" modified="2009-02-10" version="1">MHLMYYNDSNGKRVYTLKKETAAGKITESAHPARFSPDDKFSAQRVACKKRFGIYLPALPQKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPQ9</accession>
    <name>B7FPQ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177256.1">
        <property type="nucleotide sequence ID" value="XM_002177220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPQ9"/>
    <dbReference type="STRING" id="556484.B7FPQ9"/>
    <dbReference type="PaxDb" id="2850-Phatr42836"/>
    <dbReference type="GeneID" id="7196435"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42836"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030461_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPQ9"/>
    <dbReference type="OMA" id="PRDNDVH"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37306" checksum="11FF55937D3707F2" modified="2009-02-10" version="1">MNLTWTKLEPIPDPIHGLPCARSSHGLSVVNNGRCLILYGGEHVARTPIESASSCWALDVDTNVWRLINATTNSPPIRIAHAQAVHNDQNVYVFGGRAGITMEEKAMNDLWKLDASGEPGTEKWTQIFPQTDIIPEARSFHRMLCIGDSLFVFGGCGQVSGRLNDLYRFDLNAMTWHLLGNAALRGRGGPNLLSLGSGNNLAVVAGFAGEETCDGQAFDISKSMWNKEMLSTGLQGMRPRSVSVAASFPNTGIALIFGGEVDPSDRGHEGAGGFENDIVILDEKTGALKETILSANSGNWPGPRGWSAGDAHEDSNGGSQLFLFGGLSGDDENPTRLNDLWRLEIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPR1</accession>
    <name>B7FPR1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177257.1">
        <property type="nucleotide sequence ID" value="XM_002177221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPR1"/>
    <dbReference type="PaxDb" id="2850-Phatr42838"/>
    <dbReference type="GeneID" id="7196436"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42838"/>
    <dbReference type="eggNOG" id="ENOG502SEER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1725873_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPR1"/>
    <dbReference type="OrthoDB" id="5313at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="235" mass="25821" checksum="1736CFBA256832E0" modified="2009-02-10" version="1">MTTSTRILLRTELVATLILVLGPLLLPGCHGFPRVLVRQGTSRVISPARRGLLYASLEDETTLSSGSRRKCLQISLQSFILSTMTSVGFANAAMKSDQNVFKVGKDLTDEEALARFNEGRKSLKYLLDNFDQICTGGGDNIRRYLGTVGTTSGLWGISKVMRSLQDKAEDVIEFTETMNEVDASLRGADSAAYMAIFVSTSSSSTPPEKYFEDARIESKRALQAMNELAEQIDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQP0</accession>
    <name>B7FQP0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Digalactosyldiacylglycerol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_43116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177439.1">
        <property type="nucleotide sequence ID" value="XM_002177403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQP0"/>
    <dbReference type="STRING" id="556484.B7FQP0"/>
    <dbReference type="PaxDb" id="2850-Phatr43116"/>
    <dbReference type="GeneID" id="7196733"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43116"/>
    <dbReference type="eggNOG" id="ENOG502QQ73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384262_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQP0"/>
    <dbReference type="OrthoDB" id="44480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046481">
        <property type="term" value="F:digalactosyldiacylglycerol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01635">
        <property type="entry name" value="Glycosyltransferase_GTB-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044525">
        <property type="entry name" value="DGDG1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46132:SF1">
        <property type="entry name" value="DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81421" checksum="209D958F95BAEC14" modified="2009-02-10" version="1">MSTAKANAVEELESGIRVADPIRADDDHRNDEIVDDQVATPIAAVEVQPRLTKTSEDVVLLEKQHVNDQGEPIDVARAEQDRNLTSESDLSDTNRKIWVVTTAAMPWRTGTSLNPLMRALYLTRGRPKHSITLVIPWLEDIKSRKKLYGDALCFDDGGKQAQEQWIREYCRERCKCEEEEQNLRIMFWRGRYHDGFGSIFPVEDICSLIPKKEADVAILEEPEHLNWFRLPTKVGKNEENQDVDRLGWAHKFKHVVGVVFFLLQLHTNYGAYIRQYGMGTSFVTAPALDALSSLVVRAYCHRLVRLSATLPSLDSDIEVTSNVHGVRSEFLSPPQRKSETTKPHAPVYFVGKLIWAKGFDKVLEVQEAYHEVAGEYFAMDIYGGGDDMKAIQRGFFGRHKSNSNRSDDSSDSLSQIESTDSMDDSQAADVFGKSESLREQILTRNRAHHVNLAGKEKYKSDDEANSEISGEEDILEGADDNAPLDILGDVSGKALSTGAETASAAMKMIESIMSAGFGAFGGGSESNSENKSTDEIGSKRSRSNVPSFMFGPARSRFKWRRTPIPARFLGVEDHIVVRDIPDHKIFLNMSITEVLCTTSAEALAMGKFVILPKHSSNEFFYCFPNCLAFEDMDDCVRKIQYALTNKPEPLTDKFVRMLSWEGATDRLYDSSGMTRDEADKLKEAGRVEKREKAARFHVDSAQKSHFVTSLLSGKMLKKALSSHSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQQ3</accession>
    <name>B7FQQ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176909.1">
        <property type="nucleotide sequence ID" value="XM_002176873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQQ3"/>
    <dbReference type="PaxDb" id="2850-Phatr43124"/>
    <dbReference type="GeneID" id="7196894"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43124"/>
    <dbReference type="eggNOG" id="ENOG502S9ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_916636_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQQ3"/>
    <dbReference type="OMA" id="CESMSEI"/>
    <dbReference type="OrthoDB" id="41889at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852562" description="DUF4168 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4168" evidence="2">
        <location>
            <begin position="79"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4168" evidence="2">
        <location>
            <begin position="196"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="34179" checksum="FB3FFACAF7CD679B" modified="2009-02-10" version="1">MTMFSSSLIFFLFAIIAVTDHANASAVHVAPQTKPKNLRQSTLGRTVPRGGNMDVGSKLFRRMHETDQMPSLFSNSELEYDKYSACLAATEGLRRIRDRSLAAEVQAAGGTGTDMKEAEKHINAQYVQNSGRVLRALGMTVAEFNALGRQISQDEQLKEKVMEQAYLYRMAATINMDRANLIEDPASAELLQAFRKDKLHLFCESMSEIEQLRSDQIERLKRSLHVDKFPANVNISDPGLLPFLSPKVRAVVEAFPLQAEDIVKKHGLQSDEFNQMLQATHSNPIFRWKIQKEIRKGKEPAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQU7</accession>
    <name>B7FQU7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_43162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177467.1">
        <property type="nucleotide sequence ID" value="XM_002177431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQU7"/>
    <dbReference type="FunCoup" id="B7FQU7">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQU7"/>
    <dbReference type="PaxDb" id="2850-Phatr43162"/>
    <dbReference type="GeneID" id="7196763"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43162"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="B7FQU7"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="146" mass="15900" checksum="186D7BC8BD86CCFA" modified="2009-02-10" version="1">MPTAAHKNRKKRGHVSAGHGRIGKHRKHPGGRGNAGGQHHHRILMDKYHPGYFGKIGMRQFHVLRNRDFTPTANIDKLFNIAGEGVYEAAKNGGGKAPVIDLVSKGYFKLLGNGQINVPVIVKAKYFSKLAEKKIKEAGGACLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQY7</accession>
    <name>B7FQY7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_3281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177489.1">
        <property type="nucleotide sequence ID" value="XM_002177453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQY7"/>
    <dbReference type="STRING" id="556484.B7FQY7"/>
    <dbReference type="PaxDb" id="2850-Phatr3281"/>
    <dbReference type="GeneID" id="7196567"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3281"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQY7"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="354" mass="39853" checksum="49EEF7F874A099F9" modified="2009-02-10" version="1" fragment="single">LIIDNGGDTLKYGWSTDTLPSLIPNKTARLPQQWTVLVGDQLSTVQNPSQLIGVTHSTERGVVVNLGNQVQVWKPADPDTPEIPAATCAVLLALAPHTPRIMLDLIVQTWLEDLGFAHVGLCVSAVAAAQNVSNDYDTCCVVDLGWSATHIVPTHRQQVLDSRAIRRVPIGGRHLINAWKHFCSYRQWNLMEQEFIVRDVWERTAYVSLDFHTEIALARRLPAGQRPYDREFEEQILNVSVERFTFPEAFFRPSDLGLPLDWASLPQAIVQSIGACPESYQPALYKTIRLIGGLALLSNIKARLLHEIRCLAPAEYDIQLDLDDKPVAEAWQGARKYAATVRYRIWSISRDEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRF2</accession>
    <name>B7FRF2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177032.1">
        <property type="nucleotide sequence ID" value="XM_002176996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRF2"/>
    <dbReference type="PaxDb" id="2850-Phatr42473"/>
    <dbReference type="GeneID" id="7196043"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42473"/>
    <dbReference type="eggNOG" id="ENOG502SEWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788630_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRF2"/>
    <dbReference type="OMA" id="FWPLIKH"/>
    <dbReference type="OrthoDB" id="46989at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="352" mass="39816" checksum="C39E7E723B7F6B52" modified="2009-02-10" version="1">MRRIQRTTLRRFVYAIALLLGILFVSVQAWEWSDVTGGSIDFSAAASLLTYEEVTEMRVRDIKRRLARNHGFSADELSRMLDKKELIQALAFEEEKLRLTAEADMKRALFKQSVLVAVIAIFIAMCWPLLQHAYEVAHVNLVVYTDRKKLEAVRCWELRTYTGMFLVLVMLAIDVLQIWLSGSILLSWVTRSKYLFPVPSIPIRPAQLMGGDISRTSLASYGINVGPMAISWILRYANNQVERWTGRAMSQAQKSQRKAERANETSQERATRRAARKEAKRAAQERATGTPASNSNRGEPSGDIPEWMAPPHGSGRHAEPQPQPPPSREHEAFLQESMDSMNIPASGFDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRK2</accession>
    <name>B7FRK2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_17226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176559.1">
        <property type="nucleotide sequence ID" value="XM_002176523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRK2"/>
    <dbReference type="STRING" id="556484.B7FRK2"/>
    <dbReference type="PaxDb" id="2850-Phatr17226"/>
    <dbReference type="GeneID" id="7196068"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17226"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_0_1"/>
    <dbReference type="InParanoid" id="B7FRK2"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000003">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="268" mass="29090" checksum="557C22A6BB36AFFF" modified="2009-02-10" version="1">MIAYCDEKGTEAESGQDLEIKTKGQPEDFCTRVDIENENLVMEGLLKSFPTHTIIGEESVGNNPLPPLTTDPTWIIDPIDGNTNFASGLPLTCVSIGFCDKKNPVIGVVYAPMTDEVYLAVRGYGAYRNGVKITQRETKALCDAVVCFEFGYARDQEAVDKMVGAVRKILEHGCRTCRCLGSGVLDLCYVATGRLDVVYAGVAGEGWKPWDYCAGFVVATEAGCTMQPIAQLSKTDFDIYSSSVICGVSSNLVQELRATISRKCMAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRP4</accession>
    <name>B7FRP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_17265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176576.1">
        <property type="nucleotide sequence ID" value="XM_002176540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRP4"/>
    <dbReference type="PaxDb" id="2850-Phatr17265"/>
    <dbReference type="GeneID" id="7196256"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17265"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FRP4"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="126"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="663" mass="73626" checksum="813CD5510732FF70" modified="2009-02-10" version="1">MEPSDKLFARSYHFLDEHGENIPLRASIGGSSWTAAGGGSLPHHRRQRKTLMSSSKTRENQHESFNSSASSVRSIATRWSDNTLVQSVLMADGLYVPDVEVETSPEQLPSRYSKANVKSKATWFGALCLAGIGMFVEAYVIITTGQIKTIWHSNYPTCWEADKDQPCPNKIQCCVSYAEFAGIMIGMLTFGTVADRVGRKQAGTLTSIVMIAGIGGMTFFDSDNISTLFVVFSCFFAVFGFGVGGEYPLTATQAAEHHAESAEDALQDDEETRHHRLLMEKAKTARRGETISLVFAMQGVGAVVGSLLLLSLIFFSGQGRVDCYSLSANSRGTDVNALETIWRSFYLIGLIMVCMLFIYRSLVLEEGDGCAMMAARKERRETKHGKDVMKKRWWHIFWFYTPRLLGTGGNWFVWDVTFYGLKLFSGPIFDDINPGGDLMVQNGYLLINNLCALVGYYCAARVIDNPFIGRKRLQMFSFAVSAILFMATAAVFDTASSGAIMFLFFASSFFGNFGANVTTYVMAAETYPTELRGTFHGLSAFLGKAGALFANIGFTYLSTDEIFWACGACAITGFFLTYVFSVDLTGVSLAEHDALLELLYANRVGRYRGKLNEYRHLSNFEIWTGWHGEYDQDWVRKLIADEEKTMHPIHLPGEPSLDGKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRX0</accession>
    <name>B7FRX0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177571.1">
        <property type="nucleotide sequence ID" value="XM_002177535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRX0"/>
    <dbReference type="PaxDb" id="2850-Phatr32528"/>
    <dbReference type="GeneID" id="7197391"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32528"/>
    <dbReference type="HOGENOM" id="CLU_884174_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRX0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="315" mass="35856" checksum="32473961508D834D" modified="2009-02-10" version="1">MNWEDSFTLRSSYCSPTDPMSSSNTLLPTQTPTFGKASAPATEETTSSPGFPPVVSAKKPVSTARRYSQQMVLSGTMFSDGWRTHKPPRLIRTSPFEPLLHPQQLPQYSDISSHQVQQYYAWKDRVRGEAHCADQSFAQNRTRIFALATSDKNHEDKDDPHVPPISEIRIPKREGGCSPTSTSTAASISSHNQSSSEEHEVDYKNLYLCSHRNTQQLQRRLEYTEEENRQLKRKLIEFQRQLFSLQRNGLSSRGRDTRQSSWTIPPSRPELPRSAKRTRREMEGREHANSLAPSVSTEEPPLHDAGFPTTFSHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">C3HC-type domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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            <taxon>Phaeodactylaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177589.1">
        <property type="nucleotide sequence ID" value="XM_002177553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS17"/>
    <dbReference type="STRING" id="556484.B7FS17"/>
    <dbReference type="PaxDb" id="2850-Phatr43375"/>
    <dbReference type="GeneID" id="7197409"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43375"/>
    <dbReference type="eggNOG" id="ENOG502T2E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052185_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS17"/>
    <dbReference type="OrthoDB" id="47511at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="432" mass="47639" checksum="2CEB9D8736716A77" modified="2009-02-10" version="1">MTEGVDVIREKSVAESKTAARPSGQNQDPTRFTRNVPLSWRAFSGVAVTPAHEARCLAYEERLSTFSPSTYFAKPVSLSPLVCARFGWRNIEMDLLCCDACQAVWAVEFPPTLSAHATQRLTAMYVPQVASAHAVSCRYRAEASRFLDNRKVEDTAVGLDANTSTSQKLALPPALASVWPAEEVALLESVEPINMLKPLIAMLAKLCGKTSSSSGLVVPDSFTLSRPQNTIIGNVVLLSRLTDILTDGMGDVKEDREAFETATLLTLFGWRIMAKEKTIAASKEVSCAAPNEETLETTGISESEILTCRLCHAQLPLFQQTADFDASAIQDNSRPWKRLRRGGLDPASHRHYCPYVCGPGCEKKAIPFWKALAEQVLDSKTNQQQSSSGLSEWRESDTAWRVIERILRQGLSTKRLPKNDISDGDRTKLQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSD4</accession>
    <name>B7FSD4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177643.1">
        <property type="nucleotide sequence ID" value="XM_002177607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSD4"/>
    <dbReference type="PaxDb" id="2850-Phatr43481"/>
    <dbReference type="GeneID" id="7197183"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43481"/>
    <dbReference type="HOGENOM" id="CLU_835395_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSD4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="333" mass="37309" checksum="50C6C51F8DA740E5" modified="2009-02-10" version="1">MNCSDQDILLRRGGVVSQRPANKEYHEILKSNVMMYKGLPKEGRAQFATNIFRFIHDVVGRRFVQFDHETGSYQELQETEASVKISAAIRDDKISRAANKSNPRWILGVHDPTGTHNGQPFVHRIEANNTWRRLSSNETDQVLITEGFQNLLILPEGVKLPPSLETRSSDYASAVSASVVNPFTNDDCFFIPKDRPSRRSPMCTVSQQVALELGFQDAESFQRALSLLMGNQQQAKAFMRSRSKVTHPVPTVPSYVEFISDADSSMTEDSDAASTSIEPHPWKRTRICSVDDLDLNKVHALAGQALAPSDESSLRDFLLIDAIELDLLQTFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTR8</accession>
    <name>B7FTR8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178465.1">
        <property type="nucleotide sequence ID" value="XM_002178429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTR8"/>
    <dbReference type="STRING" id="556484.B7FTR8"/>
    <dbReference type="PaxDb" id="2850-Phatr44339"/>
    <dbReference type="GeneID" id="7197819"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44339"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562003_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTR8"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF4">
        <property type="entry name" value="ALPHA-1,2-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="580" mass="66081" checksum="3D8935D58A224C35" modified="2009-02-10" version="1">MEIPDSMVVTQQPTSHLAKTRSLDALHPSGVSETFKNVSSPNTLNRFNPNFYKIGAFGTTWLHSQTDTWLAFLTLFGWLARTTNALPRGFLYVRMSVGTETFVPPSPPPVFYGPDLHGTQKRNLHFYTHLSQSLTPHNQKEGDRDMARRESKAHKVPLRTSTNEWDEYSSVPVYHHHQRNGPFWFTNRTQSFDSDSHSMAVLAMENPQDPVGEQLLVQRSKQRFRWRTAASNESRHDPMDSYPTRRKPSRMLLYLRNRANASNVTVVGLGVLLAILSVHRVFSLYMTHRRWINAPITYMNRQCPAPSYPTIGAATATITGDDGALSRGAIPPAEIPIESSQICMTTLTDAKSTSRWQRFIRWRNFDGILELTHANKALYAHKHGYRFVDGSDWIDTSRPPAWSKIPAVQHLLQTNECEWVLWTDADTVIMNSDVRIQDFLPAAGSGKDLMVGSDNGGGYNSGVFLVRNTPWAQEFLQTWWDMRSFVRPSGLSLSGDNNAMKALLREMTDFNEHVLSPPRCTFNAFAKFLTLSESVHVLDHLDDQEWYLSENYYHKGDFIAHTPGYDNKAECLRMLLQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTU2</accession>
    <name>B7FTU2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBA3</name>
        <name evidence="14" type="ORF">PHATRDRAFT_33774</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178207.1">
        <property type="nucleotide sequence ID" value="XM_002178171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTU2"/>
    <dbReference type="FunCoup" id="B7FTU2">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FTU2"/>
    <dbReference type="PaxDb" id="2850-Phatr33774"/>
    <dbReference type="GeneID" id="7198040"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33774"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="InParanoid" id="B7FTU2"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="13">
        <location>
            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC49872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="462" mass="50628" checksum="36AB49E40B4963AE" modified="2009-02-10" version="1">MAGNDLDNLKPMEVDTRRSSENARGIRGSLLTLLSRPSPFGNETGPLACGEFEPLPKLSSCYATTASDHESPLTKAKILVVGAGGLGCEILKNLAMSGVRDVDVIDLDSIDVTNLNRQFLFRQRDVGTSKAKTAAAFINERCPWMSVTAHHGMIQDKEPSFYSSFDCIISGLDNVEARRWLNATVVGLVEFDDDGDMDPASIIPIIDGGTEGFSGQARFILPRITSCFECTIDAFPPQIAFPLCTIAETPRKPEHCIAYASILQWPREFHDKKLDSDDPDDMKWVYEKALERAKQYNIDGVTYMLTMGVVKNIIPAVASTNAIIAAACVNEAIKYITFCSQNLNSYMMYMGSEGVHCHTFAYEQKDDCPVCTSTVQKMTISKTTTLNELLQEFRAGPLRLKSPSLVSSGGKTLYMQKPPALEKATRSNLDKPVSSLVESGEELTVTDPLLESIAVGVSITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUC4</accession>
    <name>B7FUC4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178571.1">
        <property type="nucleotide sequence ID" value="XM_002178535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUC4"/>
    <dbReference type="STRING" id="556484.B7FUC4"/>
    <dbReference type="PaxDb" id="2850-Phatr44505"/>
    <dbReference type="GeneID" id="7197773"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44505"/>
    <dbReference type="eggNOG" id="ENOG502S66E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523269_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUC4"/>
    <dbReference type="OrthoDB" id="438431at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="333"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="521" mass="58897" checksum="4594DC2CD2E444D4" modified="2009-02-10" version="1">MPYSVSLCSFGQHTPKIQLVADTFDENAAIDTVSQCPTTCRALEEALEDFLDKDESASPCLRYVARKDAGWLSCRKPYHRPHSSVLGILEELEDPTADVTIRLNCYRGRESIVASHDCDCPEPHNSWERTELHLPESTVESKRTQMSLDWIDIRDVTNSAQFLSTPSSCVHFLRSLLGCDHRASPWMARRGRKRKEDAVGTVMLVCRSEPPRVLIDFRVTDACPSWYLHGMGRINLPIRQSVWCKRTTNKAEMATLLIYRVLPPRDQMSVLHPITGVPATVGCLWEIATMHPATTDEMVPPEPFREIRMVSPPYIAASEYPADLLGPLLSEHSLQVLQIEAKAIAHWTAWPEAQHYQAKNDSPLAPWNVFPLCYCFPATNVQARQWIHQTCALVPLTVELLRRHLGDALRTALFSRLDSESVLEPHTGWEDLANHVYRVHIPLIVPDGDLCGAWVDGCVETHRRGRPLIFDDSKTHRAFNYSSQERIVLIIDLARPCTFPDGTARGGHSEELDKFIEQMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUE1</accession>
    <name>B7FUE1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178306.1">
        <property type="nucleotide sequence ID" value="XM_002178270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUE1"/>
    <dbReference type="PaxDb" id="2850-Phatr44520"/>
    <dbReference type="GeneID" id="7197781"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44520"/>
    <dbReference type="HOGENOM" id="CLU_624822_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUE1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="51824" checksum="C425CD653B74CDD3" modified="2009-02-10" version="1">MRLIGVLGGFFLATTLGVPHFLVNALLQVQLTRRIIKCTGRYVSNSPNHLNSHERQASKNDHPETSSDVTRLASTNISASEYGDIQRYKNRAALTEHALKSQRNDMIAIQGKLLILQDVVGKLKIKAETKSQEATHWKRQHLDGEMMHREAQSDMKRLTHEYQQGRRELEEQTKDYQRDLNAFKQAYDSERRRWQEEQMKHTESEKDLRLKIKALQQELFDMDASFELTQEQLLTKQQHLKREKTMTQQALHAEFLTSSSLRKDIAEARLERDEALIRTRNQTTMEESMEIAKASVTAAERRESDIRVECEMLQIYILKLGAEKEILNKRLEVAQKQRDKVDKELRNVKDLSTERDSLRAEVALLKKQVETAESQYADTGNKDEFQFEKEVDMMQDEYKNRERELELLLEERTSYRILRLWQRFRERFKRRGQKRNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUH5</accession>
    <name>B7FUH5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_44554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178597.1">
        <property type="nucleotide sequence ID" value="XM_002178561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUH5"/>
    <dbReference type="STRING" id="556484.B7FUH5"/>
    <dbReference type="PaxDb" id="2850-Phatr44554"/>
    <dbReference type="GeneID" id="7197799"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44554"/>
    <dbReference type="HOGENOM" id="CLU_791010_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUH5"/>
    <dbReference type="OrthoDB" id="49060at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="37974" checksum="91CE9BCAD05219A6" modified="2009-02-10" version="1">MSGNASAAQSDDGDKDPVVTDKKAEPKVTKGKAKSAKKATKNKRFRSKKPKDMPPRPLSAYNLFFKEERVRMLTGDVASEGDDAPKRIGFEAMAKTIGKRWKELPEIELARYKAEAKDQMDNYRREMDKYHINVAKRARLEKEQAAAQKAEEEAAAAAARKTMFESNPQGDMQQMVPGLASTMGGSNSAAMGGSGNFDMEQLLRAQQGMLNPAMNVPMMGLGANFSQFYGSSGLPAGIGTGGLGMGMGQTNSQFFPGSMMQGNSFPQQDNSQHMMQNQNPMAFQLEQHLQQQQLQMLQQQQLLMQMSGAQGQQPPYGSGGGSGDISGFPAGPDSSFAYSDQNTFHGNPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUH8</accession>
    <name>B7FUH8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="2">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PGAM_5</name>
        <name evidence="9" type="ORF">PHATRDRAFT_26201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178324.1">
        <property type="nucleotide sequence ID" value="XM_002178288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUH8"/>
    <dbReference type="STRING" id="556484.B7FUH8"/>
    <dbReference type="PaxDb" id="2850-Phatr5605"/>
    <dbReference type="GeneID" id="7198078"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26201"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644757_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUH8"/>
    <dbReference type="OMA" id="SINCNTH"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="426" mass="48571" checksum="E289B702944EB863" modified="2009-02-10" version="1">MLVPHPSGTAMRGLREEACRFLSSRSFGATVDATHARMGGNFVNSVQACNNGKRVCWHQRNRRTFSVVATQRNGIGHRTTQGEMEAVPRRHFTSLNQSTPFQLCFLRHGQSTWNRDNIFIGWTDTPLTDDGVLEARVAGKMLHKSGIRFDEVHTSLLRRSIRTTNLALMELGQEYLPVHKHWRLNERCYGDLVGKNKKEVVMQHGADQVKRWRRSYDEPPPPMSDDHPYHPARDPRYQNILDELPKSESLKNTVERSSLYWDEVLAPALREGKTLLVVGHENNLRSLLMRLEDIAPEDIINLSLPRAVPLAYRLDENLKPLPREDGKLDEATGFLKGTWLGGDQAVSEILDRDHKQVYDTAITTNLEIGQDREKWNNWMEFIMGKPSAKQKRIGGDKQNGFAGGAAIPGVNHRTFTLQQERKQESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVR4</accession>
    <name>B7FVR4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178750.1">
        <property type="nucleotide sequence ID" value="XM_002178714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVR4"/>
    <dbReference type="PaxDb" id="2850-Phatr34337"/>
    <dbReference type="GeneID" id="7199766"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34337"/>
    <dbReference type="eggNOG" id="ENOG502T6P8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1051553_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVR4"/>
    <dbReference type="OrthoDB" id="57576at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="265" mass="29432" checksum="A8289959021AB31E" modified="2009-02-10" version="1">MKHSQLSSVTDASEQSPLADALPKPGAGPHSQRKPTPSPLPLEWTRVQRKRKLPVNASSSQENAADLDEYCCDDASCRHVIRLRREQQGEPENNAHDQGTPSASHRRYVGKAIFLLHDSNPDWIQGYFFPNGAIKPWGLLAVQQDIDECLQCTAGGYRVVQLTILPFDRTNMIKKQSVAAVEWIGGDMMCLKHPLVQMQGEQLVTGEKAVPTVETIFATLLTKLRSSRESESTTTPVLKLLPDLAIVSGTMQILMPYSDVDDMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVS2</accession>
    <name>B7FVS2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178754.1">
        <property type="nucleotide sequence ID" value="XM_002178718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVS2"/>
    <dbReference type="PaxDb" id="2850-Phatr44823"/>
    <dbReference type="GeneID" id="7199545"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44823"/>
    <dbReference type="eggNOG" id="ENOG502SV28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272433_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVS2"/>
    <dbReference type="OrthoDB" id="48583at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="473" mass="52319" checksum="B0E77CED9AF04CDD" modified="2009-02-10" version="1">MAEEIQKQYGCSYTQDHQHDEDVRHNEDLPFAITEHQPLHLDCSSEFLPHIPSVVQKRHGEVSQESSERVTPHLATSITSVRTDDQSLATSSAEYHQHSLIQPDFNLVEDAASMIDPNASLQLGASQQRKAYVQQHQSNDRHEMDGQSPTLSSLWDHADDRIPIHNRANLRLQAFPEDDTTVASTKGNSMICSFPDLHNPNLTPHLTTRTRQNHWIPIRNPFIFGAAGSLVPTARVLSEERRLASLAGATASVTGDKSFVVHIDFAVPSGFREVLDVIGNPDMLQLWCDPIRDLIITSSSEGAKNALYREGGGPSSRNRAYEGEWIDATATQLVAPANTSVVFRAGRILSAMMGFPVYGTITMFVERQRGQVSLTIGPFPGNTEVCHKIKVTETGPQKIRIADEVQLGRKEHGDCIGRAFDWMQTFFLPSTDDYIDQVLSSMARLRFLIENGEATAPAAVDHSLISPLLSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVS3</accession>
    <name>B7FVS3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EB1</name>
        <name evidence="12" type="ORF">PHATRDRAFT_54306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178755.1">
        <property type="nucleotide sequence ID" value="XM_002178719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVS3"/>
    <dbReference type="STRING" id="556484.B7FVS3"/>
    <dbReference type="PaxDb" id="2850-Phatr54306"/>
    <dbReference type="GeneID" id="7199546"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54306"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FVS3"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="256" mass="29203" checksum="F87C44803F7B91D9" modified="2009-02-10" version="1">MMDGAYFVGRKELLDFFNDLLDLNLSKIEQTASGAIACQIADLIFPKTIPMSKVNWEARSDYEFVQNYKLLQAAFTKHEVQRHVDVNKLIRAKYQDNLEFCQWLKAFYDQSGVVRKDYDPFAVRARGKGGQQYNAQMGSKSSTRSHPIMASTKPAIARVSEAAGENMAINDELSLKTLELEQAVIDIEKERDFYFRKLRDVEIMFQVYQEKVDDGDQNNLVDDVFKILYATAEDNLTVNDQGDVVEAVENEPADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVT6</accession>
    <name>B7FVT6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_11288</name>
        <name evidence="16" type="ORF">PHATRDRAFT_11434</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178761.1">
        <property type="nucleotide sequence ID" value="XM_002178725.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178763.1">
        <property type="nucleotide sequence ID" value="XM_002178727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVT6"/>
    <dbReference type="STRING" id="556484.B7FVT6"/>
    <dbReference type="PaxDb" id="2850-Phatr11288"/>
    <dbReference type="GeneID" id="7199778"/>
    <dbReference type="GeneID" id="7199781"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11288"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11434"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_2_1"/>
    <dbReference type="InParanoid" id="B7FVT6"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="2"/>
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            <position position="24"/>
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        <ligand>
            <name>L-threonine</name>
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        <location>
            <position position="47"/>
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            <name>ATP</name>
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            <dbReference type="EMBL" id="EEC49459.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC49461.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    </evidence>
    <sequence length="357" mass="38696" checksum="1D936710F8E09CCD" modified="2009-02-10" version="1" fragment="single">TLQDLDACGGRLRRGDLVSFPTETVYGLGCHALDELACRKVFAAKERPLTDPLIVHVNEEAKAQELWQATADSLEGRILACLIHEFWPGPLTLVAKATSSVPSVLMAGTGFVACRSPSHPTARALIASAGVPIAAPSANKFGHVSPTCADHVFDDLRYEDVWIVEEDEPLQVGVESSVAKLEMQDKARGVLTVLRQGAISVLDLQRCLRKANIDSVQVRANTSRSTSDEEANVAPGQTVRHYSPNIPSFLVSKYCVESYMNDGNQSKLADTVIVDYGETMLSWKEYCAAYRDLSSVADSTKAAQAVFDTLRWAEQVEGASRVLFPDLEVDDESDALILAVKDKLTRAASGVVLESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVV7</accession>
    <name>B7FVV7_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11356</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC49470.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVX5</accession>
    <name>B7FVX5_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyceae</taxon>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178783.1">
        <property type="nucleotide sequence ID" value="XM_002178747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVX5"/>
    <dbReference type="PaxDb" id="2850-Phatr44864"/>
    <dbReference type="GeneID" id="7199574"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44864"/>
    <dbReference type="eggNOG" id="ENOG502QU5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042215_1_0_1"/>
    <dbReference type="InParanoid" id="B7FVX5"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF2">
        <property type="entry name" value="LYSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852695" evidence="2">
        <location>
            <begin position="18"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="492" mass="54131" checksum="35A92594F0522448" modified="2009-02-10" version="1">MRHHILALPCILSMATAFSGTQPSIRSSSTAPSAATMLSMSDNSSSRSDELSRRQLGELAFAASGLGVTYFGTRERDPLDYGLWGVLPVGTYKKKKTILDTIIPDNMWTFDQKFGILDVQVPLRMTVTRLSSGGLFVYNPVAGTPEMVGMLQKLVDQYGPVKHIAVGSVALEHKVYAGVLAQKFPSAQVWLTPGQYSFPLNLPESFLGFPKSRTRAMPASIDDAPEDWKADFDVAVLGPIISRDGAFAETVFFHKPTKTLLVTDTAVQVTEEVPAIYDSDPSPLLYHARDTITDNVQDTPETRKKGWRRIVLFGLYFTPSAITIKDFQSAIQERRPDINSDFAGIYPWDWDGDEIASWRALTGDGTKPLVAPILQTLLLNRSPVEVLDFADKVSQWPFTRIIPAHLKNNIAMTGDEYRKSFGFLEEKGVPLGYPKPLQSDLQLLLDAEQSLVESGAIKPAPPKVGGQYSRAEIIAKTSYQCRAGTCAPQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW00</accession>
    <name>B7FW00_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_44882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179017.1">
        <property type="nucleotide sequence ID" value="XM_002178981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW00"/>
    <dbReference type="PaxDb" id="2850-Phatr44882"/>
    <dbReference type="GeneID" id="7199588"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44882"/>
    <dbReference type="HOGENOM" id="CLU_641703_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW00"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="428" mass="49165" checksum="D6F46D46478D1B9D" modified="2009-02-10" version="1">MTTILDDATYRLSSWWYNGDNHRTYPATLASRTPGFTESWGRDEDEEGKELPSWFAMEQNQLGLVLQQPYPQAPITLFQYHVAWDIQWALRDAKVDFVVVNVPHAFSESTGPLPAWNDLTEPERPILLGHSQQGIFDYLRKHHDWNVDEELSTPAGTHQLELWRNQVESLHVCLDLLRYGPGQEWSKIYRDQSMKASCGETQPSWLRRILAEWNVTAEHHRGRYLRRHIPTSNTVDSAQKATGIASGIYKRLSVQLADKDYLFGTTKPSSLDYEIGGHLMDASGFVPLRDAIREHDNLVSFAQRLCSQGPLLSEWNRLENERNAFQVEWLWLNVETLAPCVGPRDARSVGNHDKYNPWDTWHRWRFGGTFYPASTRAEAKTAETLKLQQDYLHQDQLWWSAVTAASLVSIGVTQWIVSMTTLSARASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW95</accession>
    <name>B7FW95_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179121.1">
        <property type="nucleotide sequence ID" value="XM_002179085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW95"/>
    <dbReference type="PaxDb" id="2850-Phatr34638"/>
    <dbReference type="GeneID" id="7199918"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34638"/>
    <dbReference type="eggNOG" id="ENOG502SZD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886998_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW95"/>
    <dbReference type="OrthoDB" id="55579at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="34220" checksum="1CB8DDFE56F99E15" modified="2009-02-10" version="1">MRLISSSYWIANLWTSPIKATPPPSSLHTQGLTAACNWLTVRPSAARRRCVRIRHLAHFRDQADHDLGYLTPLTATTAHPNQTLPEFDNILGEADLTSELFADLTIKFQIRSVEHCISQESESLMRRLSYAALLLLGTVVASNLLGALLYNSNAAQEWRYWWPLTGVVYVAQAYQNLSEKDFGGKSVPLLPFPIISVWANILAGLCGIGLVVGGAYDAFMPVWMMGPNVVTEAGIGQDSAVALMLLTAYSVLNCTTSARSFKDTDSGIHSWCSPHFPNSAQLLAQIALLSQLYILGDGSINAILADVFSALPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWG5</accession>
    <name>B7FWG5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179153.1">
        <property type="nucleotide sequence ID" value="XM_002179117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWG5"/>
    <dbReference type="PaxDb" id="2850-Phatr45099"/>
    <dbReference type="GeneID" id="7200299"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45099"/>
    <dbReference type="eggNOG" id="ENOG502S48R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1206834_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWG5"/>
    <dbReference type="OrthoDB" id="204260at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="25517" checksum="180BC6833B61EBCE" modified="2009-02-10" version="1">MIDISATMSTPLSPRITDNGLQKHCASLHAADSLPPSKKRRLSDEEPFEALSPVDVARSMLSNVKQGLRTKPSYSISDTDLDGYTMEKVTAIRNKDVAKLRSMLTDDAASFKACNRNGETLLHLACRRGGVDVVKFLIDEASVSPNVVDGLGRSVLHDVCWKSTADVVLMKTLISRISPELLVAEDIRGHTPFDYARREHWAEWNVFLAESKDCIRSRLEPDSDALYMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWJ6</accession>
    <name>B7FWJ6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_56522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179172.1">
        <property type="nucleotide sequence ID" value="XM_002179136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWJ6"/>
    <dbReference type="STRING" id="556484.B7FWJ6"/>
    <dbReference type="PaxDb" id="2850-Phatr34741"/>
    <dbReference type="GeneID" id="7200318"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_56522"/>
    <dbReference type="eggNOG" id="ENOG502QZ78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1681345_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWJ6"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852750" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="230" mass="26066" checksum="A7A2F7A7632DBC79" modified="2009-02-10" version="1">MHSKTSHQRHLRRRGVLIFFLLVSTLTEAFQVARTRSRFPSCPISGGATSATILYYSNTTDGSEVAQRSFQDRMRELALPTKNLKTNSRGPSTKYDVQEITSLAQYKRIVGDEPSKLSVVRFYAPWCRACKAVAPAYYSLSKKYSNYDVQFLQVPVTRETTSLHQGLEIPSIPFAHVYHPVGGLVEELRFTRKHVTGFDQILQSYKDRSCTLPTDVDPDTGVFCAPYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWK6</accession>
    <name>B7FWK6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179177.1">
        <property type="nucleotide sequence ID" value="XM_002179141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWK6"/>
    <dbReference type="PaxDb" id="2850-Phatr45136"/>
    <dbReference type="GeneID" id="7200195"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45136"/>
    <dbReference type="eggNOG" id="ENOG502SMWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332748_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWK6"/>
    <dbReference type="OrthoDB" id="48713at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="847" mass="93443" checksum="9A37AB574094411D" modified="2009-02-10" version="1">MSNPRQDDSKESNMIFDSPTGLASARIGRRGVSPRPTSPLSSDSSTASATSRRSTSMIRSPQDAELFHQMGAATGVSIGRKNKNKVRVTSPLHSPASPAVSNANMTETTGLQKGGALDYIMRSFSPKSTPDKEELHQSTNDQGEPIMDPGFKLNVPSLLGTHRPEESKPTEVAKVPHFFSNQNLNARTIPKTHQYKPTGQAQLSSPVEEKPNNSLLNECPNVYTGTSQGTSAKQSQESDAIDAKGPLRICPQDAASHSGSAQTGVSSRSTLDLKNNDNSFHVLANLMVDLLHPKINDSRELVLLPEDRQRIERLLPPSARINFIQAVQHRLNTMPANPTTPLQFLTLQCKELCLDQEGSRNPILASMALTGQPVYIFVGDCQKKGARNTDMRSEKSENIDDIMAMRTAESSVLNETVEATPTHHQPLQTDETPGPIFEKTQQHPMQPQRAPSIMNPFATVGSAAFVSQAVVKESPILPKRSRATPPELKVNPRDGTLDTEVLARQQLLAELREASTLMAESKTPETASFWRDHVLDLQARLRALHRESPTAAIVNPQSAQKLLDQSCQYVPPARTSNGKPLIQTFPGSNVYPSQAHGKQRLPMVDVVSPADLPSGYCFEAEMAGKRFLATVPSSGVQQGETFTCAMRDLSSVDIDIPIGHWKDKMYDVCKHGCFHAAVWNSTFCPLLALSQIETRLNLDFLGRPEHTQGGLSNRTTMVIVTLFWLCMNGVLFAGFDYKWSQRMELSYADWSALALVNLSMFGFVVFVSQSTRSSLRERFMIREQRCYDLEDLWCSTFCLPCAISQMHRHTANYDDYEAICCSKNGLPHGVRLKSKVEPPQDGSSYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX62</accession>
    <name>B7FX62_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dsCYC2</name>
        <name evidence="3" type="ORF">PHATRDRAFT_34956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179283.1">
        <property type="nucleotide sequence ID" value="XM_002179247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX62"/>
    <dbReference type="STRING" id="556484.B7FX62"/>
    <dbReference type="PaxDb" id="2850-Phatr34956"/>
    <dbReference type="GeneID" id="7199945"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34956"/>
    <dbReference type="HOGENOM" id="CLU_795614_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX62"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="349" mass="39014" checksum="F27CF43C50D810FA" modified="2009-02-10" version="1">MMKQQHSQQEDQIFDLLGVMIRQERTRYRVVNYLQREMVYECQQQQSQYVVEACASITNNQYAVKKSQSSTSLRDVQGDVGNSSPRSARTTSGPLRIESTASPVSDRAVQFSFWRQQMFDWACMVTDCFSIDREVVAASFNLLDRYVARELSSHSSSTCPDDYSPALVSPISREDFQLFSMTCLYITVKILEPYPRKLSLEALVDMSRGFYTPDDIAVTEREIMTALSWHLHPPTAIGFSRMYWSLLASTDATEPSSAVQTTCATLTELAVANAEFIDSPPSLVGLAATVLAYRLPANTNAHDTDQNGCSAAVHEAQARLLLAKLAPLVEPQAQQFHAIYTQLEALYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX87</accession>
    <name>B7FX87_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_11735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179511.1">
        <property type="nucleotide sequence ID" value="XM_002179475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX87"/>
    <dbReference type="FunCoup" id="B7FX87">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FX87"/>
    <dbReference type="PaxDb" id="2850-Phatr11735"/>
    <dbReference type="GeneID" id="7199957"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11735"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="B7FX87"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000293">
        <property type="entry name" value="26S protease regulatory subunit 6B homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="389" mass="44417" checksum="F70CA8E9D2DBE00D" modified="2009-02-10" version="1">MDMEQQKQELDFYQEVKGLEKQLEFVSLQEEYLKDEMRHLQRELLRAKEEVRRIQSVPLVIGQFNEMIDAKYGIVSSTAGSNYYVRILSTLDRELLKPNTSIALHRHSHSVVDILPPESDSTVKLMSEKPDVTYKDIGGMDIQKQEVREAIELPLLQHHLYQQIGIDPPRGVLLYGPPGTGKTMMAKAVANATKATFISMVGSEFVQKYLGEGPRMVRDVFRLARENSPCIVFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNIKVIMATNRADTLDPALLRPGRLDRKIEFPNPDRRQKRMVFQAATTKMNLSDELDLEDYVNRSEKVSAADISSICAEAGLQAVRENRYVVLPKDFDAAYKKAVSNREKEHNFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX89</accession>
    <name>B7FX89_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179512.1">
        <property type="nucleotide sequence ID" value="XM_002179476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX89"/>
    <dbReference type="PaxDb" id="2850-Phatr34985"/>
    <dbReference type="GeneID" id="7200015"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34985"/>
    <dbReference type="eggNOG" id="ENOG502S5YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081127_1_0_1"/>
    <dbReference type="InParanoid" id="B7FX89"/>
    <dbReference type="OMA" id="HELIAGC"/>
    <dbReference type="OrthoDB" id="166018at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF2">
        <property type="entry name" value="FCP1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="292" mass="33310" checksum="80115D2EC6C15B0C" modified="2009-02-10" version="1">MSFDAVATHKAIIFDWDDTICPSSFVDRYKIERMEKLPRNFQRLFEEITRLTERVLREASKYGEVILITNSDEGWVKYSCERYLPRLLPVLEGYRIVSARTLYERFYPGQPLCWKAAAFAHEVNELYESMSASDDSAMNGSMESTDVSSTDSEEEKPSMDEEEKKCINTNLSFLGEREIISFGDSMEERTAVRIVAEQLGATPKSVMFIQLPTPVQILGQLQMVAAHMKFVCEHKSSLDLEITTEQAQRCADAHLRRYKLGSYRQLQYLPRSGTDEAIVPGETTLEPNVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXD2</accession>
    <name>B7FXD2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_11795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179317.1">
        <property type="nucleotide sequence ID" value="XM_002179281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXD2"/>
    <dbReference type="STRING" id="556484.B7FXD2"/>
    <dbReference type="PaxDb" id="2850-Phatr11795"/>
    <dbReference type="GeneID" id="7200035"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11795"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859116_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXD2"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="63" mass="7310" checksum="33A1A918C2F483FB" modified="2009-02-10" version="1" fragment="single">PRLYWLDEYGSLQTVPYGAHGHGANFILSILDQGYRPDLDRQQAADLLRRCFAQLRTRYVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM2</accession>
    <name>B7FXM2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179792.1">
        <property type="nucleotide sequence ID" value="XM_002179756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM2"/>
    <dbReference type="PaxDb" id="2850-Phatr45419"/>
    <dbReference type="GeneID" id="7200537"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45419"/>
    <dbReference type="HOGENOM" id="CLU_1013595_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXM2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="372" mass="43752" checksum="596B1AEB7865D919" modified="2009-02-10" version="1">MLILRNRDEVPFSDENAGCHRHQCTVVNEVPEIPISVGTLPCGGSRRVRFNTNPAICNSNYFVIQDKQDSQQSRKTKFLWSKPFWMADEKLVRSRVFMVKLNKAASRIQSFFKGIIARKLYRATLVLRAKQAVERIRNEASTLIQSAVRRYQGRMVYSRIISAVKVQSSVRAWMTRSHFLIVKLRNQLESIENRRQQDFRMIEEYRKERILEIHQLYADRDAQTAEAERKVLEARLVVESLQKHNKKLRLQTSKLQNAIKHMARENQLMELRALSADKEVCLYRIDLQRLSNENKQWTGITLEMQQRKKGLEDALYEVNELIEFEGQVGRSVKNHFRQMMKHIQENCRDRLMLREVFMGGLPKEQLSVCEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY06</accession>
    <name>B7FY06_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_27125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179654.1">
        <property type="nucleotide sequence ID" value="XM_002179618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY06"/>
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        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FY06"/>
    <dbReference type="PaxDb" id="2850-Phatr27125"/>
    <dbReference type="GeneID" id="7200728"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27125"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="InParanoid" id="B7FY06"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13432" checksum="6CCA8770E796B7D7" modified="2009-02-10" version="1">MVKGAPKPDLVTRDYTIQLSKRIHKMQFKRRAPRAVKEIRKFAQTAMGTSDVRISSELNKEVWKRGIKNVPTRVRVRLSRKRNEDEDADEKLYTLVDILIVESFKGLQTENYVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ61</accession>
    <name>B7FZ61_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45921</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="PEFDEYY"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS51352"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC48484.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    </evidence>
    <sequence length="228" mass="25391" checksum="747D202D7285DCEF" modified="2009-02-10" version="1">MPAAAAAVKKPLLTPMEELLGTKLLEKAKGPKKDTKTLLKDKDLVALYFSASWCKPCQTFSPLLMEFYDHIEGMNVDVVFVSSDRTTPEFDEYYGHMPWLAIPSDAGAAKIKNNLSQRLKIQGIPSLIVVDAKTGEFVSDKARYEVTGTFIDEKQAQGIVTKWKGLERKPLDQGILDGQEPGGIKGLIMMLLKSPASIFAILYIYRNAGGWFKEIMDRFKQPGTDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ99</accession>
    <name>B7FZ99_PHATC</name>
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        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
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        <name evidence="7" type="ORF">PHATRDRAFT_45954</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002180077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ99"/>
    <dbReference type="PaxDb" id="2850-Phatr45954"/>
    <dbReference type="GeneID" id="7200831"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45954"/>
    <dbReference type="eggNOG" id="KOG1473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292651_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ99"/>
    <dbReference type="OMA" id="GARECMQ"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PHD_UHRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="511"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
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        </location>
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            <begin position="775"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="863"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1020"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
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        </location>
    </feature>
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        <location>
            <begin position="775"/>
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        </location>
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            <begin position="814"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114004" checksum="727630BBF5DB80F5" modified="2009-02-10" version="1">MYIDCGRGYRTVVNEPIQNSPEFVLTTANSTERRSRRMFMFLFGDEGCITSIMTSNSNSNTNTTTSTPATSASIPLDLTSSSSAPRSHNRRYLCAAPRPDQYDEHASPVLQRLGHTRASRKTLLEATLRALQTRHNLERKTGPGRKSNAEHAIHFYEYLLELVENGEEEGEDIGDADSISSASNKDEAEHERNVESVNKNTLKDENNATEAQEDSVKSELDEASSMDTATFVKAHNDLCEVCDEAGDLLMCETCNLVFHVACVRPALETLPEQDYKCAYCVLSTEPKNSRPRKQAAAAVRLMARLRNQFQRNKRRGRNDAGDSKRDNEDEDQIVSSDLGDKPSEASGNEEISKLEPSAGTDEEKSSEEEKDKTNDTKDTTKEIADPRKVTEDRTNIEEATPLASNKRRKLELYRITDAFSTPENMEDGRSKRNRKQPMLYDPQAGPARKWQSDEPKYWNSDSQSDNSISGESETRDADEKDAFGTVVKKVGSARKENGEIHCSFCEDDPFIELCCFCGCRVCFGKHHQSKLLLCDECDDEYHTFCLSPPLKSLPASNAEWFCPSCSVSQQRRQITTKSLSSRIGTRGAMSKSPSPTRISSRQAATKASHSTSLTEHVKRGPGRPRSKDRILTVAVGKKRGRPPKSASQGSPDKKRAKTEPTTKLSSQTPKSDDGKARSKSLVGAVSDHDPVTDYISATAPIQEVKISRSGRPVKRGSFHDEIEQREQHLRSDRSHPISPSKAITNQTSSTPATIPAEIIEASTIADSESDSLKATKTTSVLQGSQQASANATALENASPSPVFSEPASPPAPMNNKASKVSVKVSVSNPTPNVQPSVRINTVPSIATIPPMVEPTPVSVPPTAMKPVSAPMSSSTSTSLPTTGQSTLLSPSKISDPAPATNNVEPAAVISTAAITMAKAAVPQPLTASASVPPPIAQNKEVKVPRRKPGARECMQISRRFGVRAIPQKYMDIMTDYCKRGKVEHLIRMRERLDDHSRFLEAQLAGLEALVLEKGESSVVVPSMPSGPDRKLERTLGTEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZG5</accession>
    <name>B7FZG5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180347.1">
        <property type="nucleotide sequence ID" value="XM_002180311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZG5"/>
    <dbReference type="PaxDb" id="2850-Phatr35863"/>
    <dbReference type="GeneID" id="7201062"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35863"/>
    <dbReference type="HOGENOM" id="CLU_666426_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZG5"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="603" mass="67361" checksum="A1FD2F243D8E99EE" modified="2009-02-10" version="1">MDLSNKSFHDIFLQVMVGHPDDDIHRDAHMQDTRRSSHPNDTSPLPSDVVIGWRSLCGSVLPENIRAHAEAYSATAVSPHHSNTRRTTQATANSVTISNRTFPLDSKQLSDPSNVPASNHNENSYLYERHSPVPLVSPFLPDMTDWDNSMQLGLQPIFTDHDSTFASAFGKTYVSPETLPVPALPAPPPAFDRAHSLAFSVSSDCTSQSALFFHPISNPTHDPPVSPLKPCFLDTPEQPVVPDIVHNLPIEPRPTKKLRTTETINNDDLWPRALWPQPTPQLAINTTCAPLAPPPAQHDSQPVVLLPMPIVWPKTPTALNTNLTFDTSWLSAAQVATKKSDPVVKRNKDSEQISASTLVASRPSVVDPRLATFLERFDNAEWRLQALQAENAELQAKVQEAERQKRAMQQLARRHLFQSVVNVAGVAIVGKRPKNMAWVTLRARRHAGTMLHHHCNSSRFLCTDRVVIEERTMTLNPRNRPNRHTFLCEYISDVDACGRRRWNRTNSRSIRAVAKSRRTVCATAVVAPLLRIRERDLAHSLLSKGFLSRAVSRRIPHELDTIRPAMVMLASLPHGMGTTWSQGKVVEVVLKHRSCVCVESWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZM1</accession>
    <name>B7FZM1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL12 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_12354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180172.1">
        <property type="nucleotide sequence ID" value="XM_002180136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZM1"/>
    <dbReference type="STRING" id="556484.B7FZM1"/>
    <dbReference type="PaxDb" id="2850-Phatr12354"/>
    <dbReference type="GeneID" id="7200766"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12354"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZM1"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="77" mass="8283" checksum="483DA5048FE6AB6C" modified="2009-02-10" version="1" fragment="single">EAAPAAKTVFDLKLVGYDAKAKIKVIKEVRSIAGLGLKEAKELVEGAPKTIQKDLKPELAEELKAKLEEIGAQVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZU0</accession>
    <name>B7FZU0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180365.1">
        <property type="nucleotide sequence ID" value="XM_002180329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZU0"/>
    <dbReference type="PaxDb" id="2850-Phatr46032"/>
    <dbReference type="GeneID" id="7201403"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46032"/>
    <dbReference type="HOGENOM" id="CLU_515348_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZU0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="529" mass="57854" checksum="DCCFC7E68C460B61" modified="2009-02-10" version="1">MRFKDEPSYLLQNAEEGKVQDNIEVERFGHLPPGMLDTETSLGKNSLSNETIEEDSFPSPVEISQAGNVTDADSIAADSNSTQPYLQANDTGFSGRHTIQSIAKTYANKSGTFVSENKFNTMFAGPTGAHDKSPIIEIPSIVDVIDGNFENKGNSSKLKSAYVVSKEADETDSLAGNASSSAETSPMTSERGSEPWSMESINNSLITKPVAASELEHKHVKDLVQINRISEESGGTQYKKSLNGGENDTENLSTHSKLNVVPSTFFNESALTSPEAFVMSKLTSNHSGWPDPVTPASLVERREMDANVTQLYSTGSSYMSIATEKNATGVAKTLTKSAKRKPFENTTEHVNIKGYLKADGATRPKTMIATTAKSNITNIAVSQASLSASDANVTEWQSEALRNISKTDRDHPHRSLNLSAATFHQESVLRNKTHKFLHDKKTRHSHGKSPDKTRSSNKEKQIDTTDKNSALSPTRNTTLVVKEVKKQSREQNDPHVHDDDTGQHSESRNTTILKMHKSSARKSLRVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZY6</accession>
    <name>B7FZY6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_12894</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180385.1">
        <property type="nucleotide sequence ID" value="XM_002180349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZY6"/>
    <dbReference type="FunCoup" id="B7FZY6">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZY6"/>
    <dbReference type="PaxDb" id="2850-Phatr12894"/>
    <dbReference type="GeneID" id="7201316"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12894"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FZY6"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="259"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="403" mass="45211" checksum="9FCE31FCC04AC7A0" modified="2009-02-10" version="1" fragment="single">MVEQALNNLDHAYRLYGPESVICSFNGGKDAVVILHLVRAAHARFYDQQRNLDGNPIEPLRPRVVYFEHKDEFPEIRSFLREMVDVYELDMIAFEQGIKFSEGLKTLVTHNVPQNSNVSFPVAFVLGTRATDPNARGQGTFAPSSHYMPPFMRVNPVLEWTYGHVWHFLRLFHLPYCGLYDQGYTSLGTTKDTIPCPALTVPGGNTTNAIPRYWPAYMLRDWDQERAGRLSKPKANKTVDDTSSSASRTTQLSAMTTVGVLIIGDEILKGLTADTNTLAAAKAFREKNVLLKRVVIVSDDSDEIIQEIHRLQNEVDVIITSGGVGPTHDDVTIKSVAAALRFDMVLHEEMADLLREKMSNDADTELTEAQVKMATLPNASKLRYLSDDPSDWPVLQCRNIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G054</accession>
    <name>B7G054_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180417.1">
        <property type="nucleotide sequence ID" value="XM_002180381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G054"/>
    <dbReference type="STRING" id="556484.B7G054"/>
    <dbReference type="PaxDb" id="2850-Phatr46126"/>
    <dbReference type="GeneID" id="7201352"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46126"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="InParanoid" id="B7G054"/>
    <dbReference type="OMA" id="GLYMVFG"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18694" checksum="4356F70242E63855" modified="2009-02-10" version="1">MHAHFEQVIQKVDALMAKYPTITQADRLQQLETQTGYPKALFFVVLSTILTGVLTLIGGAKLLVDLVGFLYPAYMSFKSMDGGSIDDTQWLTYWVVFSFLNIFESLFAFVVNLIPFYFWIKIAMVIWMWHPNTHGAQTIYQQGLRPLLVPYMDAVGGKSNKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G061</accession>
    <name>B7G061_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_36022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180621.1">
        <property type="nucleotide sequence ID" value="XM_002180585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G061"/>
    <dbReference type="PaxDb" id="2850-Phatr36022"/>
    <dbReference type="GeneID" id="7201354"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36022"/>
    <dbReference type="HOGENOM" id="CLU_2325287_0_0_1"/>
    <dbReference type="InParanoid" id="B7G061"/>
    <dbReference type="OrthoDB" id="42764at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="250" mass="27686" checksum="4187DF534C698DBF" modified="2009-02-10" version="1">MASTGNQQLAVHLNNMAVSFLTFQNLNKAFELLREALFQTICVVDPHCSETVDALVADRTTKSGPILYQSLAVKDSAFQDTEEKRTGCSCASITFVYSDGIRLLPSGIAFSCDNLVNEIAVSSIIIFNLGVAYHVNGLETYSGSQLTKSLSMYQKAYVLLLDVGIPPMPTGNAMVDLLFMALFNNLAHVCFELVNYEESERYFDSLYRFAYAISPIFYDDPAARDAIEQHKRNFLLNAIILKTPNFANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0P5</accession>
    <name>B7G0P5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Trx-f</name>
        <name evidence="3" type="ORF">PHATRDRAFT_46280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180517.1">
        <property type="nucleotide sequence ID" value="XM_002180481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0P5"/>
    <dbReference type="STRING" id="556484.B7G0P5"/>
    <dbReference type="PaxDb" id="2850-Phatr8091"/>
    <dbReference type="GeneID" id="7201216"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46280"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_9_0_1"/>
    <dbReference type="InParanoid" id="B7G0P5"/>
    <dbReference type="OMA" id="MQIMKRE"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="174" mass="18537" checksum="BB8B1D8325C09CC5" modified="2009-02-10" version="1">MMQQQQQQQHAAQRRAGVGTILLSLWFVPAATAFAPSTPLAFRTQTPVVTTIAKVARTPLTLSAVVDIGSESAFDQTIASAGGSLVVVDYSTTWCGPCKVIAPKFEELSEKYGDAVFLKVIGDASPDASKLMKREGVRSVPSFHYFKNGEKVDVVNGANAEAIEAAIAKHGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1K3</accession>
    <name>B7G1K3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181043.1">
        <property type="nucleotide sequence ID" value="XM_002181007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1K3"/>
    <dbReference type="ESTHER" id="phatr-b7g1k3">
        <property type="family name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr46539"/>
    <dbReference type="GeneID" id="7201834"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46539"/>
    <dbReference type="eggNOG" id="ENOG502SWPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742853_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1K3"/>
    <dbReference type="OMA" id="METISWA"/>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855714" evidence="1">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="41296" checksum="FCB4EAEDEAABE668" modified="2009-02-10" version="1">MAMLWQILSWLLGSVDKSIGLVRWMLPQRARPKFFADGWGKYELAFGAQDEMLSMLKSSDKRNRFRTELENGSIQWSQPVVKSSVSVTSGAFPSPVAHLLPDKAKICRFYYVQPIIEEKRKTVTIIMLPGTGEAGKGDRLKMATQLADECGWSSIIVTAPYYAARKPDNQTAFFVRTVEDLLLQSVAIMQEAAILASYFLHRSEQQRVCITGFSWGAAMASGAAAVALTTAHKDAGRRLACVPYVGCSSPSILVSGVLESSIDWTALQQKPNEPHGETHAQALEVLGRFHLSPLNDAVQSQNKSIAALHIVNMQHDYFIPQRFSREFTAELGRMTSDTSNRAAQVLPGGHVVAMLVRPWYQKRAIVDAVHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1K8</accession>
    <name>B7G1K8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_46543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181046.1">
        <property type="nucleotide sequence ID" value="XM_002181010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1K8"/>
    <dbReference type="STRING" id="556484.B7G1K8"/>
    <dbReference type="PaxDb" id="2850-Phatr46543"/>
    <dbReference type="GeneID" id="7201687"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46543"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G1K8"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="119"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="532" mass="59469" checksum="9427A3D7D06AD4C5" modified="2009-02-10" version="1">MASQKQPQRKDSDVSEKSDSGGGDPYASADYQEALEDVHTRFILNLPPSELETADRLFFQLEQAWWFYEDWICDPHPEKVLPRFSSFKPFAQKMFAYSEMLPESHKFGSMWAEFSQYKRGISNYGCILLSVDYTKVILCQVWNGKTFTFPAGKINQGEDGLTAAARETYEETGFDPNCVFGQTASWKATDPAKITWKSLQEQDALIFQEDNGKRRTCYVCHGVPEDFPFLPVARKEVAKVAWYRVDKIPKSSYAVFPFLSQLRRWIAQRTKSSRDKSTGRSNARKKGTPKRSGNNSRGRDSRGKVRDGDGLVTSGLAAPGEVSRWSEDDMFAVNERLLGRKITYDGNPHLFEQGFQGQDPHAFHVVGGSFLNTNDSTLAPPPATSKLQPLFRGSNNDTGKDELLPFFSDDGATPWGETVEDAKGAPPPRALKDDADALLALLQQTKDPPKSLLTTGNDVDVAFLTDAEVTARSNETKTTDRRVTMRAQYEADMEFIREWVANLPKPGPSKHFGTFKLDADAIMANALASVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G243</accession>
    <name>B7G243_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_13553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181311.1">
        <property type="nucleotide sequence ID" value="XM_002181275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G243"/>
    <dbReference type="PaxDb" id="2850-Phatr13553"/>
    <dbReference type="GeneID" id="7202236"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13553"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_1_0_1"/>
    <dbReference type="InParanoid" id="B7G243"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="250" mass="27827" checksum="3BD085E00EF04E0C" modified="2009-02-10" version="1">MMFVLSFYWTAQVGKNILHVTVSGVVGTWWFAPEDASSFCSPAINDSLLRATTYSLGSICLGSLLTALLQFACQLTREARRHTRCNAILRCVLECLVDFLERLVAYFNQWAYVYVGLYGYDYLTAGRRTMSLFMERGWTIIINDNLVLRVLGLMSVLMGFLTGCFGLIIASIKSSWLEDFGNSAASVAFCIPFLIGAAVAYALMSVVASAIDTVLVAFAEGPLDFERNHPGLYTQMITAWRQVYPEEFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2B8</accession>
    <name>B7G2B8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181351.1">
        <property type="nucleotide sequence ID" value="XM_002181315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2B8"/>
    <dbReference type="PaxDb" id="2850-Phatr37171"/>
    <dbReference type="GeneID" id="7201994"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37171"/>
    <dbReference type="eggNOG" id="ENOG502SCPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1334164_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2B8"/>
    <dbReference type="OMA" id="CVENCCT"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47698">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47698:SF2">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16036">
        <property type="entry name" value="Chalcone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855742" description="Chalcone isomerase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="206" mass="21946" checksum="48503E119860EA23" modified="2009-02-10" version="1">MVRVWMTLALFLSVTMTAASAMTDKATGITFAPKKNDLEIFGVGVRKKGPIKVYSVAMYCQNSVKEHLNLISRSADKGKAAFKALRHGAHEASSTTFLLQMNFKVGAEKMASAIADSVTPRYANTAEVESLKSLIFKGVAGKGAATKGTTFEFDCSKEGVHVSVDGKSQGKVASDGLGAAFCDVYLDDKCVSPPLRESCLETCFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2U9</accession>
    <name>B7G2U9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181267.1">
        <property type="nucleotide sequence ID" value="XM_002181231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2U9"/>
    <dbReference type="PaxDb" id="2850-Phatr47207"/>
    <dbReference type="GeneID" id="7202192"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47207"/>
    <dbReference type="eggNOG" id="ENOG502S66D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234632_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2U9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="149"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="475"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="757" mass="84155" checksum="143D45D1A89C0299" modified="2009-02-10" version="1">MTERLQVQEDAWKNPVIVEATDLNRPKSPVPGVTSEPFAPQTSERMDSAGEVESPTPANRSTDFRRATATINPLPEPPNFLAPCTGLDASLDANLLTESGNETSNILPEEYVPHALTFAMEHRIFLKAALDLVAERDRRAPEVGMNDPFVLKLGPLKKASHLMNGVWKVKYVEIRRGMFSYYENASSKDTTGMGDLLRKNIPLEVSLCCCRAVKLHQKALNLTPNGAIFEMTFSGTRRLWMANSRAERQAWMQTINAAMVGGSLTRSDSVTNHSGALRGVSPRSPFKNDLRLYLRMQHLLRTAKSQSEYTPHLQELSAHPLTVPVRWIAKQQQAALRNATGEEVAFREEAVNLSVEQLWRDLQRDSVLINGELFMGASGHGPEKMMGALTRELLTVSDEGRGELNESQAVAYARDILLSGNRTRSGGDSYFCANSLCRNCELAVVVPSAAIAEPVSITVSRDGTDVPESRIYSSVHDKSGWIKTRSKMQRTWRKLFFVLSEGTLSYYERAHPQPHRLRGQLVLTDGCISISRKQTKQDDKPTNQFVMSVTSKEGSVRILLFESEDRLLDWTYSLEFTAKARASEEIGKKGRRRSSHDIADGKADSIETAKSATKGHFDALGIDASFVIDRLALHEKKMAYTTLISIQASTEYKICTIDPQGDDQLDVWATLYTQFLQNFRVAGGPNSRIMRGEEVVRISIAAGIDTSHEVQEVPSGNPVLITTANTPSSPRRSRKGRTYFRSFASNGDETEEVPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2W3</accession>
    <name>B7G2W3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181274.1">
        <property type="nucleotide sequence ID" value="XM_002181238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2W3"/>
    <dbReference type="PaxDb" id="2850-Phatr37368"/>
    <dbReference type="GeneID" id="7201981"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37368"/>
    <dbReference type="HOGENOM" id="CLU_364685_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2W3"/>
    <dbReference type="OrthoDB" id="10502803at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855763" description="CBS domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28464" checksum="20E5FC94DBEE4D7C" modified="2009-02-10" version="1" fragment="single">MARTVIRTTFSPRRMALSIVVLVVATTMFQPERNGVTAFSPRVPTHRFASRTLSTSTSSSTSSFLRSSPLFGSSIDDGMLLRDECIITPEGYGFSCPTSRILKESGRGQGFYKASASESVIDVMEAITSGTSDVALVFQGDELLGLFTEADYIKFAQARALASSTEQQSAEFLVANVRDYITPAQDLIALSTQDTANVAVAAMKQAAVRHLILADTVSSDRKLVSSSQVQGVISMQDVMSVIQKDERLSLQSLAKKYPNIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3C3</accession>
    <name>B7G3C3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181592.1">
        <property type="nucleotide sequence ID" value="XM_002181556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3C3"/>
    <dbReference type="PaxDb" id="2850-Phatr47426"/>
    <dbReference type="GeneID" id="7202558"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47426"/>
    <dbReference type="eggNOG" id="ENOG502S2TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036679_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3C3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598:SF4">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="490" mass="53617" checksum="1FC22AE4487C86D3" modified="2009-02-10" version="1">MALLARATSLITGLTLIMLFQELYSYTVSPQPFLHSKTETALSYTHPNRYRSRRHLIENKMFSTSNENEETPNDADEDGDHENDSYMVNASSEFLDDTSASSGNMVKSESSPAKTLDWGGALGKLRQRVEDMESGKAGDASQVLFRLMSSESPNQAIGSFVSSANPQVVQAMSGAVSSLLGGLSNPQMGADVLVKASGDKIGSLCFHLQMTGYMFRNAEYVMALKEVMHLRGSTSLQDYKDAFDRIDADNSGFIEYSEIKELLDDVYEGSTPAYEVESFIKFFDENNDGKVSWEEFERGLGSAIAQQQQLVKKLNLLAPAALDDDDDAPNLDPDVTGIVELELENGKIVEVEAKEYIQSLKKEAQALKDALRREKFGGAPPNPRAGNGSDLSANEPGEGFGGITGYIASRQGDLKALTQGISPEIVSTMKKLVDFVLEGGESGQTKNVPKEEIHMEIPGSALQQLALWQLILGYRLREAEAKGDYLKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3C4</accession>
    <name>B7G3C4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_28737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181593.1">
        <property type="nucleotide sequence ID" value="XM_002181557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3C4"/>
    <dbReference type="FunCoup" id="B7G3C4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G3C4"/>
    <dbReference type="PaxDb" id="2850-Phatr28737"/>
    <dbReference type="GeneID" id="7202458"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_28737"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="B7G3C4"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="407705at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="48056" checksum="F2A35858760633C4" modified="2009-02-10" version="1">MGKEKVHISLVVIGHVDAGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDNLKAERERGITIDIALWKFESPKYSFTVIDAPGHRDFIKNMITGTSQADVAVLVIDSSQGGFEAGISKDGQTREHALLAYTLGVKQMIVAMNKMDDKTVKYAEDRYTEIKNEVSAYLKKVGYKPMKIPFVPISGWEGDNMVEKSTNMAWYKGPYLLEALDSVTPPKRPTDKALRLPLQDVYKIGGIGTVPVGRVETGVIKPGIHAMFAPSGIIAEIKSVEMHHESLPEAVPGDNVGFNVKNVAVKDLRRGFVASDSKASPASGVSSFEAQVIVMNHPGQISNGYSPVLDCHTAHVACKFALIKEKMDRRSGKVLEQNPKFVKTGDACIVDLEPTKPLCVESFTDFPPLGRFAVRDMRQTVAVGVIKATTKEEGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G431</accession>
    <name>B7G431_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181845.1">
        <property type="nucleotide sequence ID" value="XM_002181809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G431"/>
    <dbReference type="PaxDb" id="2850-Phatr47557"/>
    <dbReference type="GeneID" id="7202788"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47557"/>
    <dbReference type="InParanoid" id="B7G431"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855727" evidence="3">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="453" mass="49372" checksum="D256B07DD5228341" modified="2009-02-10" version="1">MQLHSLSKILLLLVIVHRSHGQFPQVKDRHSLTEEDYLRQQPSLLRGSSNLPLSRSNLLVRQRNSFGQHQQRTRREKEDEDDDDQDDEIDQPETDELSSDFPTGMPSVVDSPMNESPGDQPSSSPRAIPLEPFSLKVQNSDEWDVDLATDSLEKYLFTNLVVENGVESVTLNLVDVVVDSVNDVATSLTSTEPNTRRALQSQNVTRSLTTLEYQGTVTVMESETTVAPADNKESLWSQQSRLLQDNADVVSTVVNQNQGNPAILVGVAVGVDGSSSAASNADANDEGPRTGLAVGLTFLFLAMAVGGLVYWKRRHRQLGEPEAPKEMAASSDDSDSSPTGDKDGLHSGNRSSAVTTTARETDHDSDDDDVDWVAGKKPLYNMLSIVRPSVSTDARRAVHTNPWLSPSSSDDLRPDTLEYCASDDSSLYTSNTTSPQGGASDDGWELALGQGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G437</accession>
    <name>B7G437_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182003.1">
        <property type="nucleotide sequence ID" value="XM_002181967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G437"/>
    <dbReference type="PaxDb" id="2850-Phatr47563"/>
    <dbReference type="GeneID" id="7202628"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47563"/>
    <dbReference type="HOGENOM" id="CLU_482757_0_0_1"/>
    <dbReference type="InParanoid" id="B7G437"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="331"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
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        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="471"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC46543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="565" mass="63608" checksum="71BDAFC723141C82" modified="2009-02-10" version="1">MKTSRRLTNKKQQQGCKNKLSILNGEEKESSYPDSHDLAHVDSFANWPDIYSQKTNLSAMHQSKKLNEPNPCHNFEEPTKKATMHESPLSALIAAVNKEFTECEEKGTVSKAEQKEVDAIEDPMTAEMIIHDISRPVHISARNLHLRLENTIHPETLLHQNALSDEESTPDILESTIDLRSQSWVWDHLEESPVAPTPAADQEKSAAILDSCGSIQTVSFGIGSPPKKDFERKGVLSRTETSRNKKLLSSKRFSLWSRRWHDSGQVQSKSKGRRLSTAIAALCRPRSKTKREDTVTSSEKSKESSSTDQTSNRKDLKNLQREPAKVVSSLSVAHRKKDYSFQMSDPLKNKKLLPSECPRQNRGRSMLATPIRSMTQRNRSLSQVTGLSRPRSFYRDNSLAYTAGRNNEAFETGKLVEDKSGFNGTWNDWSQRLVAATAVCWDPRPIPSEITTTKAVTTCRRVAYEPPGTKAEVRDEHCEQEQKSECKDDNYSSSGAMGNSLSSSGEIEYEMNGTWKDFWEKAPSVLQAMENEIHILCGFADASVCYNESQHKGRYRYACSVVQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4J7</accession>
    <name>B7G4J7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKP4</name>
        <name evidence="12" type="ORF">PHATRDRAFT_47689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
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        <property type="protein sequence ID" value="EEC46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002181890.1"/>
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    <dbReference type="PaxDb" id="2850-Phatr47689"/>
    <dbReference type="GeneID" id="7202697"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47689"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000445_114_51_1"/>
    <dbReference type="InParanoid" id="B7G4J7"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HisKA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="HATPase_dom"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
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        <property type="entry name" value="PAS_fold_3"/>
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Response_reg"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="293"/>
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        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="433"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="711"/>
            <end position="830"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="77"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
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            <dbReference type="PROSITE" id="PS50113"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="838" mass="94245" checksum="335535C6E8513B20" modified="2009-02-10" version="1">MVPLDALCVASAIAHDPSGEMIQHNEAFQNLVLLKDRTEPEGVMDGKMEKTDSGELIEDCDSSLTPTEGSSSLSEEVNEKYIDPTKGDTIWDILELKPGFFGKETKRIYQGDGQPNKWVSIHISTIDSGELGRTIFVQVEDVDESLRAKDQWTAILETSFDGFWDYHIQKDYEYMSPRFWEMFGYAPHEKEHSPSAWQNMIHPEDLKVTMEHLGRHVASRGEYPYCLETRYLHKKGSWVWVLCRGRVIEWGDDGSPIRMVGTHTDITETKLKQIQERELHAKIEREHKRVVAANEELRRFVQHVNAPVFGVDNDGTINIWNLRMVEITRIAEESIVGKPLACSSVKNAAIMVQNALRQKEVTNSLLEIEIPSDGESAAKSLSLLVNTTTRKCVDGTVLGCFCFGLDLTEIQVANQKLVQERERFTAEKTLNEFVAHEVRNPLAAALSAAQFVRDTLIGADVPTELRASLRADTYVISTSLDHIHQLLTSMLDLNKFLAGGLTLSPRQVNLENDIVEPVYVMFAHRAEKSILSYEVPDDCYIEVDELRLKQILINLASNAIKFTQEGYVRIKAGRFDAGRHNMLHIYVEDSGPGIPAEKRWLLFQRYVQLSKQVQGSGIGLFLTRHLVEAMNGTIEIDTTYNSGIQEFPGTRFVVKIPLPDSKLVSPKCTPEKAIDDSSAMLKLSLASERAVDPSESLSVLSQAECFPPHMRVLVVDDDKIIRRILARRLQKLDKTMEIDQAESGEQAIAMIVPPDSKKYELVLVDHFMPLAGGELTGEETIAIIRSHVSGVIVGSSGNDMHKEHEAAGADLFWQKPVPRDSAIIEDLRRIFMAKTMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4N5</accession>
    <name>B7G4N5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181944.1">
        <property type="nucleotide sequence ID" value="XM_002181908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4N5"/>
    <dbReference type="PaxDb" id="2850-Phatr47722"/>
    <dbReference type="GeneID" id="7202715"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47722"/>
    <dbReference type="eggNOG" id="ENOG502SNM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590279_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4N5"/>
    <dbReference type="OMA" id="ACIEATI"/>
    <dbReference type="OrthoDB" id="42069at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="529" mass="58758" checksum="0CE7D6F9159ABD60" modified="2009-02-10" version="1">MVLTAPYSPSPRSGDAATGSMPNGGSIIASRPSNFATGSNVVENTYIARLIIKMNECLLKLGQDIEDDSVIEQVERMSTLIYESMSTSGRNYHSVQHVFDVSRNLEDPIATLAALFHDCIYHQVDGGLSKLQVQKLEGVVHWHESVHAVRTDKTPGSIYYTSESVKQSIFHPHTSDPLLGMVEVIFGYHEIQEMNNLNGVNEFLSTVLALRELTNLLNTVQLAQIAVCIEATIPFRPLHSETGQSPMELLYERLTQVNDTYQLGLSKVELVESIQRAVRVANRDCENFGSPDCQWFLDNTWSILPECNKSLRSHSLYTVGEFQCALYSMYGFFSFLQPSLIFQQFRGVPSPEEYQLLVDQATRNLQVGRQYVGAKLVSLSVVAAFAELTGGDAPISLFIGDLPSRHSDPVDGSWIEIVSSEFIDDERKASDCDPDVYTLLAQGRRTEASFDVRQSPLAAGFYGRLGDRGLVEILQAFDLFPMTVDTARALLSRLPRGLIMKLANKMAKVAVPRATRIQQVIDELSTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4Z6</accession>
    <name>B7G4Z6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182325.1">
        <property type="nucleotide sequence ID" value="XM_002182289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4Z6"/>
    <dbReference type="PaxDb" id="2850-Phatr47807"/>
    <dbReference type="GeneID" id="7202959"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47807"/>
    <dbReference type="InParanoid" id="B7G4Z6"/>
    <dbReference type="OrthoDB" id="10678215at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="316" mass="34513" checksum="5CAA5ACD7AA2DE5F" modified="2009-02-10" version="1">MQGSPQPQEMHRQGREGSSEMTSRIVTERLKNGQCIHCSIQTHQVNSKRMGLKRELIPLTVPGQVENGCCLRESCLLAGCNVAVSDPRPPKIPTARKFAMATSVGGVTGSLFSLAGLSELASLAVPINDSSMSSSDSTKVSQTTPDYLNTHLHHQSQSSSVLRPLEQYQLHAPLRPEESQSLIPSHSTSDPSAGSCSVETLGNQDDEGLSHPSQAFQVSVNNLKHQFKSRRAVREDTMLRGRFAEAPVGYVTTVFRKSQTVKVLSCAIRAIGWSAIMGFAPSEATFLVWPVLWGIWRHWLVYQAISLSIAMCVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G522</accession>
    <name>B7G522_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182340.1">
        <property type="nucleotide sequence ID" value="XM_002182304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G522"/>
    <dbReference type="PaxDb" id="2850-Phatr47828"/>
    <dbReference type="GeneID" id="7203065"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47828"/>
    <dbReference type="eggNOG" id="ENOG502SV7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1430602_0_0_1"/>
    <dbReference type="InParanoid" id="B7G522"/>
    <dbReference type="OMA" id="NIEMVGD"/>
    <dbReference type="OrthoDB" id="42858at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855844" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21137" checksum="76BCB18A475FCE80" modified="2009-02-10" version="1">MLRFIISALLIGTMSVVSGFGVVSSRAIAQHRFTSRDARSMKLFAIRCEDKYYQLEEMEDKENCTTELYLKGDRTVEFGDTDGPIWTEAVGSWQVKPGTNDFTMVIKRKYQTGRDGTDMGSFDFQTERTFSGEMTQVGACVGITGVVHEADNGSPLQEEEIGFFNMIDATDERLKNSGGDEKLGKSATSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5L3</accession>
    <name>B7G5L3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182266.1">
        <property type="nucleotide sequence ID" value="XM_002182230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5L3"/>
    <dbReference type="PaxDb" id="2850-Phatr47990"/>
    <dbReference type="GeneID" id="7203217"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47990"/>
    <dbReference type="HOGENOM" id="CLU_687872_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5L3"/>
    <dbReference type="OrthoDB" id="41872at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="391" mass="43909" checksum="4A0BEEACB8AFC316" modified="2009-02-10" version="1">MSAAIRNEANSKPRDRRLRSNLLMKLVIMSGVGALGGFWLFYSVWETQCSDLLNQAQIRHSAVIAELQELHTKQTSALQNCVEGDATKEKALAERLKTQSTLVIKHHDLLQQYDEAKSRIARLEVELEGVTQTNQSLNEQLERLQNEVAESARSTQGAEKQIVLLRTQLEATRSVIKQSCAFNETIDMSSQRHKEEVLQIYAAIQRQSFAQLFQRFGEGPYEVEFLLSTESTTETVAHETFRVELLRSKDMPHTVLTFLSLVELRLYDGTTIAGTDGTVISGGIPKQAQTRAQSYLMRMYVEHGFGFSPLVIEETSPTMPCMAHTFGFTERGPGFIIPLESMSKNESPSCPGRISSGRDVLERLARDRESQLTIIEAKLVSRDIGSHDTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G679</accession>
    <name>B7G679_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_48168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182529.1">
        <property type="nucleotide sequence ID" value="XM_002182493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G679"/>
    <dbReference type="PaxDb" id="2850-Phatr48168"/>
    <dbReference type="GeneID" id="7203307"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48168"/>
    <dbReference type="InParanoid" id="B7G679"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="332" mass="36840" checksum="03558C75BBFB1997" modified="2009-02-10" version="1">MNEHSRDLIKRASETEANFDNHFFGSSNSFGSLFSLALARQNSSCGSLNALLSELGNASYASQNVLCSAASVNRPLVPESSTQRPTSMANYQWNNPVDPVQSHSYVHQHNEGVDALLGLSSVGVKRMGSSSLPVSALHQRQHESLSSTKFQNSLAEPMPKKQRHELASFGPHLSAGPTATRRKTDLFESLGNTISPDVSRRMVQAETLSMSHPIPSMTRLQDLMTQSNKTREALKALSREQQLLEQQLERNTCDFPKFASFTTSLQSQCNQTASFNQRQLSQNINCDKIWSCTNQNNGNEYVHVVNLSKCKAMELGPSSNNQTIWNYPAMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6I4</accession>
    <name>B7G6I4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_38671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182732.1">
        <property type="nucleotide sequence ID" value="XM_002182696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6I4"/>
    <dbReference type="STRING" id="556484.B7G6I4"/>
    <dbReference type="PaxDb" id="2850-Phatr38671"/>
    <dbReference type="GeneID" id="7203389"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38671"/>
    <dbReference type="eggNOG" id="ENOG502TM6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_910495_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6I4"/>
    <dbReference type="OMA" id="SWQDERK"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="306" mass="34490" checksum="82DF35650CDD5DBA" modified="2009-02-10" version="1">MSEKINSSRGSYEVFNAVDELVAKPVLGSDGAAAWQSFRNDKSVLKHAYRSTPSVAPTAPLKAADRASGMKSWQDERKVEAKTRQETGAAEINAGYTNFQRKGGDEEAISRKKRKQIESRIRPEDVPYCLPAPTFQGWKFDYVFTTRDRKSGYYWDGTDSVKQLRGDVLPEIAPRIVEDFENPTPTDELEGLAKERKKRKKQGPVFVHDPNHPLEQVSAALRRSHPALPLGWEAAKDRATGKTYYFNRTTSQRQWEPPPALLGKFTEEGTDTPKLVAGWDTAVDSASGKTYYYNVVTNETKWDRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6P3</accession>
    <name>B7G6P3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor beta propellor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_48306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182766.1">
        <property type="nucleotide sequence ID" value="XM_002182730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6P3"/>
    <dbReference type="STRING" id="556484.B7G6P3"/>
    <dbReference type="PaxDb" id="2850-Phatr48306"/>
    <dbReference type="GeneID" id="7203783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48306"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="InParanoid" id="B7G6P3"/>
    <dbReference type="OMA" id="WERPANK"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="7">
        <location>
            <begin position="265"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="704" mass="76593" checksum="F9C17F09471F34B6" modified="2009-02-10" version="1">MTSSNSLSTRPCQILIRSKTALELFDVPEHPSDPISALRPPLLQGPTTFLKTSPDGAFAYVHIAGHGIVRIDLRASNNGSTATDTNTAPFSISKENTPTFLSDTAAVQMMDVSPLGTFLLTWERYYADKKEPNNLKVWNAADGQLLAAFAQKTLKREGWPYVQWTHNEAYAFLHTPSEIRIYTPESLLHNRYVDNLRIPGILTLNLPRTRILSSTEAHSAPSYMFTSFCGGTKDKPARASLHEYAPGTGTGSSSAANPYPALLSKSLFQAEECVTHWNPAGDTALLTIQTSVDASGQSYYGSSQLFLLAKHLPTVQAVPLPQEGPVHDVAWMPSLDINKPSSFLVIAGRMPSLASMHQGADGKATFLFGSAHRNVIDWAPHGRFVLLGGFGNLSGSMSLWDRNKLKLIPSSSAQNSNVNGTLRADAVVGHGWAPNSRVFAVSTCSPRMNVDNGVRIFRYNGDELLNVPWKNEQYRPNQLLEAAFVPAKPLVYPDRPQTPIKEGRANDTTDSTSITSDTIKSATAKPAGSGGRYVPPSMRGRASAGGGTGSSLAERMRREKEGNLQKAGKVEDDSKKPKASTVTSALTGRSIPGLVIQSKTKSKSALKKEKTKLKQAQQDEVNRKVEAQKALLMQGEPIAPVDMTKTPEAVEPSVDPEKRARKLKKMLKQIEELKQKAMDTLNDDQQAKISSEPELLAELASLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6U3</accession>
    <name>B7G6U3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_48350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182790.1">
        <property type="nucleotide sequence ID" value="XM_002182754.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G6U3"/>
    <dbReference type="PaxDb" id="2850-Phatr48350"/>
    <dbReference type="GeneID" id="7203809"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48350"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238783_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6U3"/>
    <dbReference type="OrthoDB" id="43633at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="11">
        <location>
            <begin position="184"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="509"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="830"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="1497"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1773" mass="200706" checksum="4DE29D3CAB076266" modified="2009-02-10" version="1">MMSDRAYSNGNRLPLPDDESTEGSHESSQLVVATKEDEERNEVKQVQLLARRETNHYFSFAHTIEDASQFHITNMNLAFKNLGEIITTAAQATNASFPFVTVPKFEVYGRHARLQSGIETFTFNPFITDETRAAWQAYSIQNQGWLKESRDIFLGGDEGNHQDYIDGPITPIIWQRQADGSPIPTPGPDTYAPVWQTSPPIFNPATVNYNMFSEPFSKRMYQVILNLREAVLSETLDLTRLSGSAVAPEDHEIMHDAFVSSIDTTTNVTGYKHPHSVLVQPIFSELNNRSATIVGLLQAVIPWDRYFTDLLPQGVSGIHAVLRNTCNESYTYEVKGNSAIFLGPGDLHERHWNHMERVVDMTNYLNPERTLNEPGHCVYRMHVYPTDRFFASVSNLPTVFTSVIAVSFVLMAVTFFMYDRFVRRRNEKVVVAAARSNAIVSSLFPSNVRDRLFEERDEEKRAFARTQHSGRSKNALRGFLDGEEAELDTDDDGDMYKTKPIADLFPNTTILFADIAGFTAWSSAREPTQVFILLETLYRAFDEIAKKRRVFKVETVGDCYVAVTGLPDPRKDHAVAMCRFARDCMYKMHSLTRKLEVTLGPDTADLSMRMGIHSGPVTAGVLRGERSRFQLFGDTMNTASRLETTGRRDRIHLSEETAELLTMAGKAKWIKPREDRVVAKGKGELSTFWLECGEKSKRSSSSESADETEYPEDTSAASEVSSDVAFNTTGDEDFALRSISAKVSRLIDWNVDVLSRLLKQVLARRMAEGSMVVGTSMPLRIPSRAPGKTILDEVEDYIILPRFDPKAAKHQIDPDSIDLDPDTEAQLYEYVSTVASLYQDNPFHNFEHASHVTMSVVKLLSRIVAPMDLDFDNSKDEAVKTKTLHDHTYGITSDPLTQFACVFSALIHDIDHSGVPNVQLIKENSRIAKYYKEKSVAEQNSVDLAWELLTEDNYSRLVATICPTGSELKRFRQLVVNSVMATDVMDKDLKEIRNGRWDRAFAEPLSSLSKSPRESVNRKATIVIEHLIQASDVAHTMQHWHIYRKWNERLFREMYVAYELGRAEKNPADFWYEGELGFLDYYIIPLAKKLKDCGVFGVSSDEYLNYAVKNRSEWETRGRDIVVEMITAFRKKDEKHNVTMAVPVNPRFGLLTSFAVQAIGRSNGVGHYHFVSELKLSCHLAVSDLSSKLTNMPSDHSLVTERFTLQESTGLAPVPRMETMNGATRGPPCPSKILLLPKPSSTVEAKSFTNTKQNRISSANSSHSSARLHLNNHKVEKLHQGACKATGAHIRVKLLPEHFQPSDKDVLCGRGRACKMWKGNQDYRELVVSNLEAYASSTSKLHKGMILSNIVQRVRINSPEGGFVKKDSETGRWYEVGDFLAREKTSQYFRDALHEQYSSSAQAKYNRRKKRHTDGNYLETLPPTSSVFPPSAANPIDTAMHESSDVPLVDTIKTAVLEKRQIPPKKRKIERRPSEDDVASVLQKMASVKSTVVPDHVQICPLQVELRRPDESPMNATQRVVERMRTVALQTKVDLFILPELSPVGYSEDTFAKYLPNTPQNQQLYQNIDDIFAYQARRLQVFVCYGTIGWTPREDGTLKLSIRQVVLNRLGQQIASYDKMYLCGYGDCAETRFFEPGPREPVSFAIDGFRFGLLICADIRYPELSRLLVRDHKVDVLLQPAAFLRDVSFRTWKSFRETRAVENSVYFVGVNYSGNDFGETSVTPPWVDDSHKPEVLGTDEGFLVCKVQKNELEHVRQSMPFYRNLFDIFKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6X2</accession>
    <name>B7G6X2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_54892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182931.1">
        <property type="nucleotide sequence ID" value="XM_002182895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6X2"/>
    <dbReference type="STRING" id="556484.B7G6X2"/>
    <dbReference type="PaxDb" id="2850-Phatr54892"/>
    <dbReference type="GeneID" id="7203579"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54892"/>
    <dbReference type="eggNOG" id="ENOG502RXR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002996_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6X2"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="69"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="523" mass="57371" checksum="6CDC62D8AF531953" modified="2009-02-10" version="1">MTEYETIASIQGLDGDSFNPHQDAALDLSILAERDIIGIDSEVSTNHFCASIHARTMPKEDEDCRTPIDLIVVLDVSGSMTGNKLKLCKKTLTMLLRVLQTQDRFGLISFGSDARVEFPAQAMSKQNKASALQKIQSLTTRGCTNMSAALGLAVQELKIIEKSNPVRSLFFLTDGLANEGISDLDGLVSLTRNCLLPSDNPSNVLNSEVMIAECLDDLATSQHQITRLPVAEIESVCRAPITLHTFGYGRDHNAALLESLADTTQGGAYYFIEDDSNVGSAFGNALGGIMSIVAQNAVLTIRLPSEAEARGARIVEVYHDQAIKRENDIYTVSLGDFYAEESRDVIFKMELTKPAFTSTLPVAHVEVTLAYTDTLKKMPANTDAFIGYVRRPVGAEYSAQNHYIEGQLLRVLAIREMKSAEDLANQGNFQEAQNRIENIIAKCRQASPTVRDMQSISLLVDDLFDAKASVHSSSTFRQSGMHRMAHRRLEHVNQRSNMVNATGGAYATTTRVAYAKMFQSKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7K3</accession>
    <name>B7G7K3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183158.1">
        <property type="nucleotide sequence ID" value="XM_002183122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7K3"/>
    <dbReference type="PaxDb" id="2850-Phatr48527"/>
    <dbReference type="GeneID" id="7194773"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48527"/>
    <dbReference type="HOGENOM" id="CLU_1242213_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7K3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="223" mass="25135" checksum="3F831E14DA7D68FE" modified="2009-02-10" version="1">MAPNLHRLSTLSQSLSDFRELQSFVRSKDLASPETTGPQQAQPVESASYWEWTTEPTVASATDLFSAARIESNLINASRVGASEEPSKCNTSSDEYWAETADQVCTDASSPTTPQHKLVKTDDSYWTCSHQKTTADKYWSWEASNVDVANSVPSSVPKAKTSDDSQSYWQWSHTRTDSDSYWKNATDVKAADTKPCYWEWSYETGDSEEYWKWNTPMVATFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7T9</accession>
    <name>B7G7T9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183074.1">
        <property type="nucleotide sequence ID" value="XM_002183038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7T9"/>
    <dbReference type="PaxDb" id="2850-Phatr39098"/>
    <dbReference type="GeneID" id="7194813"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39098"/>
    <dbReference type="HOGENOM" id="CLU_878437_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7T9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="326" mass="35548" checksum="8D418659A558EAE5" modified="2009-02-10" version="1">MLPSQNSMSGSDKIGPPISVVAYGDMSLKKRPKVHGSSCKGKSKRFLITPTASGIHGSLSSYDRQQLVLQPIEESNAFTVLIGTVTANARSYPGVTEEPKSSERSNLSSTTAMSTASTGGDQEKSTKNSDLNKKGRNFCDQLVAMRCSVERASCSNNAVSIRSPVSLHFKRTTTGVGEEIQRTPTRPTITTAIIRQSSKAEILQATVPTTIDCITKAPSTSTDFELSSWDKMFLLHVSGSHGLASSSSAIQPALADARIQQRNYCHNFRKYQARSEATHVKFGAWMDEQRALLAQLETIRPTYETNFQVLQARTRLNLLALCGIQL</sequence>
</entry>
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    <accession>B7G7U8</accession>
    <name>B7G7U8_PHATC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183077.1">
        <property type="nucleotide sequence ID" value="XM_002183041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7U8"/>
    <dbReference type="PaxDb" id="2850-Phatr39107"/>
    <dbReference type="GeneID" id="7194816"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39107"/>
    <dbReference type="HOGENOM" id="CLU_066987_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7U8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="294" mass="33322" checksum="2EA8B1D65961F0FB" modified="2009-02-10" version="1">MSRTSNSYHHRHQAYFHPHEDEFAAPSTPFYHQFHDVFTPVPSRTSRYCFEEKDVRHLSAPPMLQTCLAVEECPKASTSPPSRRLPSSPLVKRSSTPAPTPSCTRSSATASPSPAISLDDEAIWSCDSGDTFECPFDYYEKVLEHAKTYGFTIARSFERYWEEDQQKFGVVVKKGYIYCNVLKCQRGRRGCCFGIRFVHVPKRGVYKINKCNGTHLHELAVGQHNNGRRRAPVVTQKGCKRLRVETSPENKTVSAAVFAAPGMKPMLRTKGEPWGYPDEYFSCTSVLGRSSYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G837</accession>
    <name>B7G837_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183124.1">
        <property type="nucleotide sequence ID" value="XM_002183088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G837"/>
    <dbReference type="STRING" id="556484.B7G837"/>
    <dbReference type="PaxDb" id="2850-Phatr48683"/>
    <dbReference type="GeneID" id="7194915"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48683"/>
    <dbReference type="HOGENOM" id="CLU_895631_0_0_1"/>
    <dbReference type="InParanoid" id="B7G837"/>
    <dbReference type="OMA" id="CHAPIDI"/>
    <dbReference type="OrthoDB" id="196927at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="311" mass="33392" checksum="9C01E4932D82A828" modified="2009-02-10" version="1">MIPLRTNLDEQQTMTEVAFPTRGIETDGESALIPLTPTTSASVSSQLPETDTSRPIGHRALHVACKHDPDLTVVRRLVEAYPEHLRIFDAHRDLPLHVALLHQASINVVEFLVGSYPKSVELPNGDDELPLNLAILCHAPIDILSLLMKASPAALRQQDSLGHYPLHNMIAQGCYTVEEIQQVLQSYSPAMGLPGAEGQTPLHVAVLAGGAPLDLVSSLLATYEAAAKRFDDAGMLPLHAALSQGASLPVVQLLVTTYPQALQLRDGQGLLPIEINATYGAHSSPAVADFLRLANENLDEVSRGCDLLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8S7</accession>
    <name>B7G8S7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183396.1">
        <property type="nucleotide sequence ID" value="XM_002183360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8S7"/>
    <dbReference type="PaxDb" id="2850-Phatr48899"/>
    <dbReference type="GeneID" id="7195174"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48899"/>
    <dbReference type="HOGENOM" id="CLU_757518_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8S7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40806" checksum="E45BF66B2F732E9A" modified="2009-02-10" version="1">MGARTLNSRMSTGASDLLLPLVVTSNRAQTDPTAATMASIPHTFDGQVDASLDELETHLNSMGPDIGTGLRDTTISTPTRPRRRALSYPNVTTAENSTLLYCVSTLQAIALASFSFYWILRSFREGFQSLQTTLLLCVGPITQVGWLGWRWQSLPRRLFSSPADDAISTSSNASQQQQNLQLISLLPLLSFTLQLGLYGSVWKATRALVDSIPNWVFFSLQALRIGSIVEPYYLLASGSINSTMPGACKLTCTAAWKLLDIIQGVYALLISWGDANNVDPMLLLIWSAIAVLLFAAEWFTEWACKTFVLPPCGGVSCCLVDPSMAFNTIVYHDPCPNTSKTNLTTRVLVAPGLACWSALLAATILTKGVPDDWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G909</accession>
    <name>B7G909_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_48959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183559.1">
        <property type="nucleotide sequence ID" value="XM_002183523.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G909"/>
    <dbReference type="PaxDb" id="2850-Phatr48959"/>
    <dbReference type="GeneID" id="7195240"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48959"/>
    <dbReference type="eggNOG" id="ENOG502SKRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275030_0_0_1"/>
    <dbReference type="InParanoid" id="B7G909"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1540" mass="170730" checksum="DBA37B51C157E83D" modified="2009-02-10" version="1">MSGNPEPGSDPFASTTEALDRARDRQSTTRYAESVQVVPSNSMEDDNIEVLHLDSESDKLGSLRKSARRSHRNKPKDSSHLPSGSNHTTSSTLSSTQQQLYDKDGSIYDALPPEYRHNPQATEPILHYLPKLVETAELLSLRDLLQAAEQDVRLHRARVKASLEKDTRLVRTYQLATDPSYQARQARLKQREKGLRDLRTNADAIWQALDETAQTQGLTQAERTDLQLQRWQRALEWFVACQPENVSWQDLLEKLLAGVSEDQDVSVILGQAADMCRDLVQESHQAVLDAKEQTGELEASYVVKLEAHQLFARTCLEQVQQIQESFQTSGKAALQIGHQLEHAEWKRSQCEAASILIRRWWILENLAEQEASTGIPIAVEEEVGGQVRSATCKMDPLFTEPENSLEASKALKALRAVLRTRGSGTATGSAIDTATTRSGDNPIRTRRFDLTSSLISRTSEALEQRLLNGFSKVYTAGGTYDFSSKPRPGAIDWRELRGLAQALLLFDSGRSLHKRYVDMVVTYRFPELFIVQSRGFPKRNSDSRSDAFDVDSTRTELSNLFHQVRDVCTAEFELIAHVFGSENARTDLLEGSEEMPLVVARALLQRVVSDPKNGLQARINELLANIDRVGDFDVGAKKLDTFVVVHEKAANLFSLLRDAADHMVPKNKNNIKNRIAVAVGDASTETAVDSLKGFLTSQELALTNTHRQGYINLELRLLHHDCCSSLDQAGCTLVKAPVTEPNTTLAEKGILEEYRAPVLPLHKDSLRQSGYTGILSGPLKQSILRQPLIHAADSLARARLMFGTTKRGGETTARVILGIYTQMCSFYGDCFLYPIMESLREMLPSNPPAQAPQLPFDEEADAPDLGVSRAFWVALERVHSAAKSFDRELWAENRPDSQRVWDILTMCGDEGALAIAKNMRMHLYAELERRGEMAIVRALDTLSTHVQWLLVSGGESMMATGGTRIFNQLTGQSGGPYAIPSGSSLDTPNSPAVKSLTYCLRVQFVHVQAALSASSLANFWTALSMRVYDILVARLLQHYQVSTVGAVILSRDVEALRSVAMLAGTDHSHWDTLRELLTLYMTPPDAIKTMLAGADGDAAKGLFAKAGRDRCLVFLSRRNDYRFKTAAGPKKSSWVTDLLTELNVTDPSDGVINIGSFAAEHREPSGLRWLRKTKTKTSTPCPLATHGIEYLPSASWFPLAGKSVNSFVVTRLSEDLQSVPASSVRLTGCTGRRRKRSSTSFHSDSIPIPFELTFYSMPPTCAQTIYPVAVIASVTKQMNAALTTLKDEIPSTMQLQPSVRRADLLDSLASSFSADHALQKKFGWLFLSQCAFLLQMIEVSFRPKIEEAPIAISSDTSWKEVTVQEGDVLRGEEMIRRHTGAVGTIIFVVRRPGTQTPFLVALTLSVLVALYPDYFIGYEIVGVIKEVGVDDAGLVEFQHEYFRFPLYRDRSYAFYRALGDRKVGLAILWNPLSLVSLMCDAYQRLRAKEIGGTTKGEGLVQGGILVFRGTEPRAMYQEQTGSDVPAVDIVSALQAIRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G939</accession>
    <name>B7G939_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183702.1">
        <property type="nucleotide sequence ID" value="XM_002183666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G939"/>
    <dbReference type="PaxDb" id="2850-Phatr48984"/>
    <dbReference type="GeneID" id="7195256"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48984"/>
    <dbReference type="HOGENOM" id="CLU_734596_0_0_1"/>
    <dbReference type="InParanoid" id="B7G939"/>
    <dbReference type="OrthoDB" id="44290at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42036" checksum="E4F2D1302941E13F" modified="2009-02-10" version="1">MVLRKLCSVVRLPNPKLCKRARPSLLGVPGLLGSTLIGNTARAFTPKATSLSCWDLPTITESGHCAPIGFFGSIVLAVAAGSSFFFEARCDEYKEGTSQEEVKDETDPYENLPDEDEETTCSMCQTFRQGPCRPFWRKLERCFKDHENEEGGATKCMRYFGPHQQCLMEFTNLYSLVSLDMKQELVHDIELSVNADERRTWEPDIDWGMWKIFVQERGLDFRETVPGSAKDTPLWKRLPANKEPVLVNPTVTLARQQEGMILKVAYAVDQDGMVLGFSFNQEYGDLIGKSKGSATLVEIDGPEQPIETNESNSVADDAKPPSSTFELEFVVFPGETTHVRVCALYAENPTLADHDKDILDALLFTGPMESLQTVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9J3</accession>
    <name>B7G9J3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_49117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183784.1">
        <property type="nucleotide sequence ID" value="XM_002183748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9J3"/>
    <dbReference type="STRING" id="556484.B7G9J3"/>
    <dbReference type="PaxDb" id="2850-Phatr49117"/>
    <dbReference type="GeneID" id="7195337"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49117"/>
    <dbReference type="eggNOG" id="ENOG502S48R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585914_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9J3"/>
    <dbReference type="OrthoDB" id="46691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="508" mass="57225" checksum="E473463F5C086408" modified="2009-02-10" version="1">MLKFVSTHRPSCMWTRRTNILGIHFSDHIFYSGGLLAVCHIYSFVADIMVDLRAQESQAQQQPVRSGARQSRIPATLQAVFLASNRGKTVEGPPPEQVANRTFFRNWFLQKQTKSSKKDSSMKVKKNKRDDISSNPVQGSETSMNTLFVKYLTFRKNVILESKSQLPIPFKELEEGSTVSPQAFLDTMISARGYSTARFETLHTAYYNMPTPLQQASYDVYLIEVVKKGGMETLRSLMKSGISPNPCNKFGESLLHTVCRLGNVDALRVMLECGTSLQVSDDYGRTPLHDACWAVKPALTVVDVILSHDPNLLYLEDSRGALPLSYIRREHWCAWIPYFRARKDMYWPDLSGHGMPPREQSPPALFMERPFSAPLPDPANALTCELAKLVASRQMLPGEAQFLKYSMMEEEGSYRSDTESEEFEGSDDDESGSDSELDSDEFDDEDEDGSYYSLEEDEMADILSTLTARAVPSKEDKTATGQQKYLFSHTSTPRNDTVPLLKVCVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAD0</accession>
    <name>B7GAD0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKP3</name>
        <name evidence="12" type="ORF">PHATRDRAFT_55037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184053.1">
        <property type="nucleotide sequence ID" value="XM_002184017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAD0"/>
    <dbReference type="STRING" id="556484.B7GAD0"/>
    <dbReference type="PaxDb" id="2850-Phatr55037"/>
    <dbReference type="GeneID" id="7195765"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55037"/>
    <dbReference type="eggNOG" id="ENOG502QPNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289430_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAD0"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="496"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="549"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="623"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="696"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="928"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112833" checksum="4628C0BF8799CC16" modified="2009-02-10" version="1">MAPNHGIQHCLVMTSVDEQAQHGLALERIGIESSVFDSIASPIFAVDRLGNVTDWNETLADLSGFASLDVVRRPAELMLDGCVDTWREALQTVQRAKRSFRCMLRLHSNQSVSTSTWYAARISRYNSYEGILIGAVCMLDEETQTFDMGKHIHVQDLRPNDTKGYEPIPDCDSRELLGGTNILIIKMDKHGRVDLWNKVSTEITGVTERDARGENISVFLTESSRKAFSDVMDKALSGEACANYQLEFLTKDGCIRYLLGSVTPRTDLDGSIAGCLVIAQDVTETAIRERTVTATALELRILIDTANVAIFGVDCDGYINEWNDTMANTCGFTGDEAFHKSFVHTFIAQDLRPAFEVVLEIALQGKFTKNYEAEILTKLGEIRYLLLNTTARRNSENEIIGVVLIAQDVTEEYKHDRAVAAMASELRQLIDTANAPIFGIDCEGDVNEWNDKTSEITGYTKEEAFDCCLVETFIVPSMQESVRHVLETALKGRGTSNYDLEFRTKSNEIRHLLVNATTRRDAENNIVGVVGVAQDVTEAVQRDRAVAGMALELRQLIDTANAPIFGIDINGNVNEWNRRTQEITGYSKEETFDEPLVERFIAKHIRKKVQEILDSALQGIETSNYELEFLSKSGEPAFMLVNATTRRDPEFNVVGVVGVAQDVTEDRKHAEELRKMQYLQALQEAKVETERNMTAYFAHELRNPLGAIDSALSVMPENIPDSAKSLVSGMQLCCSFMSSIMNNLLDVRKMEEGKMTLNKTPISLKALSRKVHKMLGPSVKPGVTFTESCTTNGKDWVLGDEHRLQQVMTNVITNAIKYTVGGSISIYMGWEGDDVKFECVDTGPGIPKREQEKLFQRFVMRGGAPGTGLGLAIAKHLVDLAGGSIRFDSDPSIQAGTACIVLLPLALCDPPEEGNNVIKMSLLDEPLKFLVIDDVRMNRTMLKRRLQTGIAPNCVLTEASTGEEALQIVGKQTFDVIIVDQYMEEAGGVMVGTDVVYAMRRMKTGFGKSQFQQTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAJ2</accession>
    <name>B7GAJ2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184206.1">
        <property type="nucleotide sequence ID" value="XM_002184170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAJ2"/>
    <dbReference type="PaxDb" id="2850-Phatr49422"/>
    <dbReference type="GeneID" id="7195796"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49422"/>
    <dbReference type="eggNOG" id="ENOG502S0CC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562000_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAJ2"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="537" mass="60009" checksum="312C01DAC10EB00F" modified="2009-02-10" version="1">MPSRRRRSNNLFFEAYCVFLRYPRTIAVIFSLLNPSTSFQLRSDQRIRLPAMGLAASTPKQEKRSEPEQAPETKQIKRRHKTEEWKIAVDTFAKQVLDPSYLHLPVRASTMEAASFYPSENNEQACLMPGTHKHLGGAYDATDGCIYGIPASAKAVMCLYPDGDKYKMTTIPLPEDAAKTTYKWLRGIFADGYLWAIPAWADSVLCVDVDAFWGRRPASGEVVQLIPLPDEHPKDMRWQWHGAGMNREKTAIYCIPSNAQRVLRVDLRMKTTSLIPIEYNPDKYPNFRIELANKWYGGILGEDNAVYGVCYRSCAVLRIDCESDTASLVGPDYGCAGYNWHGGVKTNGKIYAHPSHAPDSVLVINTNPDDHKEDPCSELPIKRAEYDKDIRINYKWLGGAIGADGNIYCPACDTSSVLKIDTQTEECTTFGFVGTLKNKWQGGILGRDDCIYCIPASGHHVLRIFTSPDIVGENPIQLIGQMPVHKDKWQGGHVGKDGALYFIPENGYRVLKVTPPNAPPSLVNGKLPEGDVKIEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB18</accession>
    <name>B7GB18_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_49563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184293.1">
        <property type="nucleotide sequence ID" value="XM_002184257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB18"/>
    <dbReference type="STRING" id="556484.B7GB18"/>
    <dbReference type="PaxDb" id="2850-Phatr49563"/>
    <dbReference type="GeneID" id="7198229"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49563"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305136_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB18"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="423"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="616"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="716"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="973" mass="106100" checksum="B62BF7C26376F858" modified="2009-02-10" version="1">MESARSRNTRDGTRKQGTARRSGGTTSSNGNQGFDEFGFGQPAFPDSAFDNHGFEMPQTRIQPTKIRSRRRASLAAAPNIDVVSENPSIGFTNQFQSSQDEQVSRGGARLAKAGRSSRSMDGIEFPTARKDVSSQNRPRRSGRRASMATSSNHSLSASNHTNPELGYGDAIPSVAANHRKGDSNSGILDFGFGGGKNAGTANADYGYGDTMSSGFGNFESMPSAPSTTPESERPRRSGRRSSISGGLESLRSDLRGGDLSGAPSSRVLGGNSRAQNIVLPMAGPEKVAGGNVRRGRRGSLLGSVGNAVGATMGGFTGGNKDKEKLDDDTTKKSKSFLKDRKAEGRRGTTRQPSADGNIISSYTGDRDRRRKPAASSKTLGKESNVSYSDRILAQRDCSCGGEGSSSSGSGSSDGSSACCRSKIWPAARCETYRTLEIDASSSMTLRRHGLRGLHISPTQSVGDESSFDVDCHGYCQDVQSILDAAYVRFLKALRRSVSSTPLAHHDRRENEKVAQHDNVQALLGIHISITTNESALVHDADERYQLDVPGPTVTENDDDDDGSYIHLTAPTVYGILHAYQSLLQLVTFVGRDSQTGAFVFAMPDTTLIRIRDGPVYPYRGLMIDTARHFLPLPLILQNLDAMEASKLNVLHWHVTDSQSWPYVSTAFPELSARGAFGPEETYTATDIALVVREAAARAIGRSHPEWLTPCGSKPRPQEPLDATNPAVYEFVHRLYDELAILFAHESFLHVGGDEVNLDCYHNSTTVQRWMRKHNMTQELEVLSYFERDLLSYVTAVLNRRPIVWQELFDSGLGLPNQTIVDVWKSWEPSSRYNATLRGHEVILSSCWYLDHLNEDWQSFYACDPREFNGTKEQKNLILGGHASMWGERVDATNFLSRVWPRASATAEKLWTGNLTAAADSAASRLAAFRCHLVRRGIPASPVGPGASCGRQPNGFPAVIDSFHDEELQEGKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB23</accession>
    <name>B7GB23_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184296.1">
        <property type="nucleotide sequence ID" value="XM_002184260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB23"/>
    <dbReference type="PaxDb" id="2850-Phatr49566"/>
    <dbReference type="GeneID" id="7198189"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49566"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600789_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB23"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="424" mass="47866" checksum="EB6B792A3ECC36A8" modified="2009-02-10" version="1">MHYSSDGHPKTNFIDDVEQGVQTDSVVSIAKSDCCSSIRSKKKYCMDGSIDAAPNTVSSLFRTSTARITLASTGELSCMGDSEMFQTISSGQVAKPLHNRFGRAFVSHEYEDNYREAINHRNDESSTHGTPKKIYFRGGTAMHFPERLFEMLQQVEELGISHIVSWQPHGRSFLVHRPREFVSQVMPKFYRQTRFTSFQRQLNLYGFTRLSTGRDCGSYYNANFLRGCPLLCRRIVRRRIKGNGVKPVPSPTTEPDFYNMEWCEDSGPRPTFHEKPSFGICGGTAPQTSCFQQILNSSAASYDPWNITSPYHEQPGYTTQVASPEIAMSHLQIPESLLYSQQMAQCCRRSNLPTASSSSIYPWTLGRSTTTENGSNEDMVEGLRQYLPDHFVENDQALILLSSICDTEEDSLYAPVDGDVFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBS6</accession>
    <name>B7GBS6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_55100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184500.1">
        <property type="nucleotide sequence ID" value="XM_002184464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBS6"/>
    <dbReference type="PaxDb" id="2850-Phatr55100"/>
    <dbReference type="GeneID" id="7198437"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55100"/>
    <dbReference type="HOGENOM" id="CLU_978132_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBS6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="285" mass="31321" checksum="127088FC4E2B6C18" modified="2009-02-10" version="1">MAGNDILKKQRPQNWSVTLFRRPGNANRLGLGLRRSTTGRVFVVGLSGDDPTSWHALASVSIGDEVTRINGALLRTLSHCDVSQLLDPQTKNGRQNGRLVLMGVCHYGNPHAVHALIERPFRDALVGLQSSCNNHEYPEILDLADKGLVTDSVLRIGDRVRSVNGIRCKISEQNLAALLDSSGRYIAIMAERVDTEDGSALIKVGTSEASSHAGRQVENETKGTICLRQRCTCLYRFVLSHSRATAKLSEAARSSLLSGFSLDVNKSYTSIMRKEALISSRYRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBX3</accession>
    <name>B7GBX3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_49793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184524.1">
        <property type="nucleotide sequence ID" value="XM_002184488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBX3"/>
    <dbReference type="SMR" id="B7GBX3"/>
    <dbReference type="STRING" id="556484.B7GBX3"/>
    <dbReference type="PaxDb" id="2850-Phatr545"/>
    <dbReference type="GeneID" id="7198460"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49793"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_1"/>
    <dbReference type="InParanoid" id="B7GBX3"/>
    <dbReference type="OMA" id="GNETGNC"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="9">
        <location>
            <begin position="634"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="874" mass="96485" checksum="C544FA3F29BAAF81" modified="2009-02-10" version="1">MSNTNKAESHQTLRTVTDDDSVTMTASPDVQYHQTNSTDPDVECPPSTPTYVSVHDLTLEEKLLLLSGQTLWLLPDLPRFNLPSLTVADGPHGVRKPVKELSLQEALPATCFPTAAALSCSWDVDFLRQVGIALGNECAHYQVAVLLGPGMNLKRHGGGGRNFEYFSEDPLVSAKLATAYVQGVQANGRVGACIKHFAVNNQESHRFVVDAVVDERTARELYYRGFEAVVRDAQPATIMCAYNKINGVYCSENEFLNTQLLRDEWGFQGVVITDWGATNDRPAAIAAGMDLEMPGSHGAHGREIRRALREGTVLRMEHVDACAQRMLNLMCRYKESVRDTYELSSWHDQHKLAKQVAMQCAVLLQNQGNLLPLKQGTSVAVIGDFAKEHPRYQGMGSSQVCTNSVVTAYDELFRHTKDVFFAPGYHADDDHIEAVNEELLAEAVRVAQQAEVVLLCLGLPEIMESEGFDRLHLNIPAQHNALVDAVSKVNSNVIVMLSNGGAIEIPWADKVKAIFEGYLLGETGGAATVDLIFGVQSPCGKLAETFPIVQEDILADRYFPGSRDRVEYREGLDVGYRYFDTAQKDVRFPFGHGLTYTTFEYGNLNVQVNRDDATSKSVHVSFDLTNTGAVAAKEVVQCYIHQDSPSVYRPVHELKYFCKIHLEPQQSKQVEFDLLTDAFSFYDIGVSDWTVEAGGFEIRIASSSRDIRLEAPVVFAEGRGPSDLAKETYPPVAGGGTLSQVDDETFAKRFAKRKEFVLAECVASAESSTVSRVGGFHRNSLLKEVASRRLMGKLLLSVVLSAAAKEVKKGPTRKRQKRMVRANVENLPLRTLVLFSKGVLSFELLDACIAAMNYQVFRAIGGFGLAFACLFKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCG1</accession>
    <name>B7GCG1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP-monosaccharide-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_23639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13205"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140358"/>
            <dbReference type="ChEBI" id="CHEBI:140359"/>
            <dbReference type="EC" id="2.7.7.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the USP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.64" evidence="6"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184804.1">
        <property type="nucleotide sequence ID" value="XM_002184768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCG1"/>
    <dbReference type="SMR" id="B7GCG1"/>
    <dbReference type="FunCoup" id="B7GCG1">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GCG1"/>
    <dbReference type="PaxDb" id="2850-Phatr23639"/>
    <dbReference type="GeneID" id="7198551"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23639"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016797_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCG1"/>
    <dbReference type="OMA" id="HMNSICI"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051748">
        <property type="term" value="F:UTP-monosaccharide-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.30:FF:000001">
        <property type="entry name" value="UDP-sugar pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF9">
        <property type="entry name" value="UDP-SUGAR PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856075" description="UTP-monosaccharide-1-phosphate uridylyltransferase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="712" mass="77659" checksum="10B8AEABD2F858E5" modified="2009-02-10" version="1">MRLAIAVSFLLLWSTASSFGTPAKNQSDRSSWRATTRLSHSSLLGFTSSRPFASFGLRGGGTPSTLTSALHLSSSSTSSDRLTDENLALLSPRGRNALERLVEYDTDGAQQHVYGHWPPPGLHDSDKQRLAEQLADLEESYPGGLPAYLSKAKVLLRESAEGLNPFDEYEAVVPQGESLSYDNEPATSTMAFADAEQAGLDVCGTAVFVLVAGGLGERLGYSGIKLSLETNLCTNKSYLETYVRYIQAMQYTARQRTGNEQLRIPLVIMTSGDTDPLTRQLLEDNKYFGMDIDMVTIVTQDKVAALKDGAAGLALDDKDRWTVETKPHGHGDVHHLLYREGLVDQWQDQGKTHVVFLQDTNALVINSVVPALGVSVTRGFHMNSICIPRLAGEAAGAIARLEHKTDPNKSLVINVEYNQLDPLLRTQGDGKGDVADPETGYSPFPGNANNLIIELTAYGKTLRGEDQGVVLEFVNPKYKDASRTEFKKPTRLECMMQDIPKLFQKEMGAEANIGFTLFDRWFTFSPAKNALDAGQDAVEAGSTAPGTMSSAESDKYIQNQRKLASLGVKVPVTMADDLVVVGGIPVTPGPRIVLGSAFGISQEAYREKIQGEMELTQRSALVMDGHHLTIKSLKVDGALVIRTGKDTFVTVDGLVVTNKGWELQELDPEQNYPEHVAIRGYTMTKHETTEYLLDEPGHFVIDASGNVQKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDR1</accession>
    <name>B7GDR1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_41259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185258.1">
        <property type="nucleotide sequence ID" value="XM_002185222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDR1"/>
    <dbReference type="STRING" id="556484.B7GDR1"/>
    <dbReference type="PaxDb" id="2850-Phatr41259"/>
    <dbReference type="GeneID" id="7199068"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41259"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355085_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDR1"/>
    <dbReference type="OrthoDB" id="44571at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="404"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="712"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="915" mass="100695" checksum="8FD8416F6A834C67" modified="2009-02-10" version="1">MSSGKPALKLDRPPALQSKATFYLFSRRTGNFSFDQLTNSSQAKRNGRLQSNKPSTLRGFPDRFDLTFGTLCLYRQSSRNLTVLSNVIAIVAERNSWAKSKSVDFSRQSAGYRSPSDLDRSSTLDTSKTGTNHKVSVLSTVVMRKKKTNDKAILGDCEANTEEINQLFVGLYRVCGFSNGESLESRESSRKQFVESMQVLCSALGQLHDERKSGELGIQSILPALEQAASRVRLVAHDFMAYLTRRVCELDFPMKKILSSLRDKPAFTTLLILSRSWRTCLNHQVQQEKTVALKAVSLLDQLYSSSRLKHPTNDLLASLQNLVNILTRMDFIALPHARIGLQLLGSPNNIQRVHSSDLSLLAVDYDMSRSTEYNKVPAHCTVDVPITWQGIENFIERDAGNFPPLTSFLLVGPEGSGKTHICDVLEKSCVRSSIAVLRPRLPLDILGQSVGEMEDVLVALVDSAKSGRQSCFALILDDADFLIATGESGIGEGGERFSGRHHIQSRSQSTFFALLDSFRSDAISCSRLILICTSKMDQDWTAGRFDRKYHILPPNEHERRLFICSNLGLHTPVKCSLTILLEDMVEGTVGRTYSEIALYCRQAAIDHASSETVAEAETLLHFLKRRLQSITPESLRSGVLDEFVDMRVWTARDLGSMETLDDSESSYHLPLFGSSAEQAWKDLQSTVIIPLCRARELEDLRNPCGFFSPRIFVGGMLLAGLPGTGKSSLAFHTAKIAARLLPTVKFLEVSCTSLIHKEVGGSERALHHLLVCARKAAPCILLMDSIETIAAVRGNDATTEGTMDRLLSTLLVELDGVQEHGQSSVSSPAGIAVIGITHNSDWIDPALLRPGRLDKIATLDLPDYQIRYGIAARDLKSGIAVPANLNLLNVIAAKTHGMSGASVAAVCKLSLYVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDU9</accession>
    <name>B7GDU9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="5 15">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PPO</name>
        <name evidence="18" type="ORF">PHATRDRAFT_31109</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="15">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="5 15"/>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185274.1">
        <property type="nucleotide sequence ID" value="XM_002185238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDU9"/>
    <dbReference type="SMR" id="B7GDU9"/>
    <dbReference type="STRING" id="556484.B7GDU9"/>
    <dbReference type="PaxDb" id="2850-Phatr31109"/>
    <dbReference type="GeneID" id="7199138"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31109"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_3_0_1"/>
    <dbReference type="InParanoid" id="B7GDU9"/>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3110.10:FF:000002">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 15" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="13 15" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855799" description="Protoporphyrinogen oxidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="17">
        <location>
            <begin position="61"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEC43143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="520" mass="56643" checksum="2E83FC7770EFE75D" modified="2009-02-10" version="1">MIAQCFLVTLSLVQSAAAFVAPRAASPFTASSHFHSPIPQLYAAAREVDCLVVGSGVSGSSLAFNLVKNHDVDTLMVERNEVVGGNLISKENEEGFVWEEGPNSFQPTPYISRLVHELGITKDLVLADGSLPRFVYWQGEGAGAKLANLHALPTNLPGDLLDFNLLTWPGKIRAGLGAIGLIAPPPTDREESIREFVTRHLGAETFERVIDPFVSGVYAGDPDELAMKAALKKIHRLEGLGDLGPGLVSGAINRFKEIADEKTSNPPDPAWPTYKGGQLGSFRKGLQTLALAAEEYLGPERVMKNTPIDKVEKLPDGRFKVTVLKDDKPIEIIAKSVCLTSPTRVTCKVAADLVPAATRLAEVYSPPVASVTMAYKKEWFKELPGGTSREPLRGFGHLLPRKMGVRSLGTIWSSSLFPGRAPEGWELLLTYIGGARDKGIADLSEEEIYKQVDADNHEILLKSDAPSGKRIGIRVWQTAIPQYRKGHLEILDALEADEAKVPGFYLGGNYRTGFFFCCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE28</accession>
    <name>B7GE28_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PFK_2</name>
        <name evidence="12" type="ORF">PHATRDRAFT_50424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185308.1">
        <property type="nucleotide sequence ID" value="XM_002185272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE28"/>
    <dbReference type="STRING" id="556484.B7GE28"/>
    <dbReference type="PaxDb" id="2850-Phatr16844"/>
    <dbReference type="GeneID" id="7199172"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50424"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294320_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE28"/>
    <dbReference type="OrthoDB" id="40818at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050929">
        <property type="entry name" value="PFKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005301">
        <property type="entry name" value="PRK06830.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45770">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="133"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="515" mass="56311" checksum="415929D2516889CB" modified="2009-02-10" version="1">MFADDCSLESVGSKEYDACDGYVQDTDIFLQKVFVAKIESLRGKYPSYQAEGEIGNNRIKYTLKPDDHPKPGSSPDVPKRARRANIQYNHFVEEREILLVDTIRKPGMEKVSRAFLRGGPRRILHFRPSQVNAAIITCGGLCPGLNNVIRELVHSLHNLYGAQDVWGITGGYHGFHNPEYAPILLTKEMVENIHHEGGTILRTSRGGFEMDKILSFLRSKSISQLYIIGGDGTHRGAYKIHEACMEAGLNIAVAGIPKTIDNDIDYIDRSFGFVSAVEAAQASIRSAKTEAMCTVPNAVGIIKLMGRSAGYLATFAALGSGDVDLVLVPEVPIVLDGPGGVLPFLRQRVKEQKFAVVVVAEGAGEELLEATNVVDRGGNRLLPPIGEYMRDRIKDYFVEHGEEASMKYIDPSYTVRSVPANGADSLYCMELAQNAVHGAMAGYTGFSVGLVNNNVVYLPIPQLVASSPRQMSPCGTTWERVLAMTGQPNTASDAIAEKGGCQHYDPLDHFHELRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE29</accession>
    <name>B7GE29_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_50425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185309.1">
        <property type="nucleotide sequence ID" value="XM_002185273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE29"/>
    <dbReference type="STRING" id="556484.B7GE29"/>
    <dbReference type="PaxDb" id="2850-Phatr50425"/>
    <dbReference type="GeneID" id="7199173"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50425"/>
    <dbReference type="eggNOG" id="KOG2196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294320_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE29"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="509" mass="50626" checksum="83572D7AB6E61FDB" modified="2009-02-10" version="1">MASFNFGSSGGSGTNNSAPGGNSSSRSGGGFSFGGSSSTPAPAPAAGGFSFGAGVGATGGAGSTSAPAFGSSSGGGFAFGAPSTGSSTPTPAPASGGTVSSTGGSGAGAFSFGTPAVASNTTAAPASGTGFSFGATPVTAKTSDSNQKPAPSQSMGSGFNFGGAPSTKQPASTSTSSGGGGGFSLSSSGTSDPLPTLGQNSDSDKHKSTTGGFTFGDSKTPAAASAFTGSDGKAASNPEGGASTSGFSFGGATAAPAPVAAASTPQPEAKSSSFSFGGSTPAPVSTPTPATPKDPVTPAPVPTPGQTAAPAPTITAPSTEPVKLEYQTLTVEETLNVFQKELEKDALAYVAEALRVAEYDAILRDSQRDMAKLAQQTQRCLVQQEEVERVLTGIAAYQTELDGTLETIETHVDELFQAQGALATVDADLERERAYSTAEAITTRFQTLHRSLQETALTLDDTRTRVLQGDVGQIVKILSQHQTSLTELETVGRRVERDIAEVQKALQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE61</accession>
    <name>B7GE61_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HSP70F</name>
        <name evidence="4" type="ORF">PHATRDRAFT_41417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185428.1">
        <property type="nucleotide sequence ID" value="XM_002185392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE61"/>
    <dbReference type="STRING" id="556484.B7GE61"/>
    <dbReference type="PaxDb" id="2850-Phatr41417"/>
    <dbReference type="GeneID" id="7199263"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41417"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="InParanoid" id="B7GE61"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="841" mass="91652" checksum="CD3A6CC960F523F5" modified="2009-02-10" version="1">MSSVVGVDLGYQNSVIAAAGRGGVDVILNGNSNRLNPSMVGFDESRKMGELATSGASSNYKYTVTAMKRLIGLAFDDPVATLEMQRLPLQFCRVPHADGVDSIGVQTSKDPDANDSATTVVPMEAVAGMMVRHMGTIVAQKIAQETNTSVEANMPQDWVLTIPSYYTDAQRRALLAGCAMVGLTGVQRLLHETTATALAYGIFKDLKKEFQADQPTHVLFLDMGASAYTVSLVAFEPGKLIVKSTTGDANLGGRDFDWMIVTWMANKFAEKFGAKLSGNPLDRPKTVLKLLAAAEKAKKTLSPQGVKEARINLEMLMDDLDFSITLTAAEYEQMCEPLLARLEAPIVQALAEGKLTAADLHSVEIVGGSTRIGCVKRALTGFLTNSGAGAAATELLSTTLNADEAVARGAALQSAILSPRFKVLPYDIHEFQAWPIQLRWDEDANDEAQGMEVDATTGAQPTNAVVMFDRGLSFPIVRRVTLKRNQGTFAVQAEYNEKALEYGLPASGNAIATFSVQAPISEEAKKIRVNVKQDIHGIIQLSSAQMVEEIADEEEPESSGAAPLKDGEEAAAPENKKKKVKKTNLVFTTTRPLDWTEAEIQKAYQAELAMALKDKLVQETSDKRNELESYIYDMRDKIGSESALGSFGTDAEKAAFITQNEAMENWLYEDGFDASKETYATKLKELQKLGSPMERRQAEQEGRPAAVSTLQQSLEKYQNWVNQEATDEAYAHITDDERQRVQSKCDEISAWMYDMLDQQGALPNHQDAVLTVFDLQAKNKDLIDTCGPVLRKPKPAAPKKEPEPAAQPEGEAKTADEVPPPEPMEGVEESEAKPAETMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEF3</accession>
    <name>B7GEF3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translocator of the inner chloroplast envelope membrane 110k</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Tic110</name>
        <name evidence="1" type="ORF">PHATRDRAFT_50540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185478.1">
        <property type="nucleotide sequence ID" value="XM_002185442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEF3"/>
    <dbReference type="STRING" id="556484.B7GEF3"/>
    <dbReference type="PaxDb" id="2850-Phatr50540"/>
    <dbReference type="GeneID" id="7199376"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50540"/>
    <dbReference type="eggNOG" id="ENOG502S0W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270271_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEF3"/>
    <dbReference type="OMA" id="PTEYAQK"/>
    <dbReference type="OrthoDB" id="191196at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031610">
        <property type="entry name" value="TIC110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935:SF3">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128329" checksum="9D96DB739F349CFF" modified="2009-02-10" version="1">MKFTGVALAVSLAQQQALSNTGGGIVGAYTVSSPSFFTPKSFGSSFVRGPSHKVFHPRRQAYQKSYATSTRATLTMFTETSGGMEELNELTEKADSSPLSKQVRKSPSFWKLAGYASIPLSAALGFGLVPSRRLAAHTVGALFTGIAGAVGKSRLDALTESNAKPAIAQAIVEAGLDDPDKAAAAVENVKTQFGLLDEDFAILTTEIYTAYLLGMVKYNPTAKTSELKELETVKNVLQLDNLQVGEAHAAAAAEWYRTTCLFTPTEDLEDPSHPDRQAMDKFLFLTERALKQGGETDEAFSFEMKRVAKAFDLSYTEVLERVAETVEPFYQRALKSTRSKLGTNQVSSAMLERARKTLGVSDATAKDLHVACFNAQVRAELGLPDATAKDDDAAAGQEDEDETVGGSVMDLAALKFTGEDAMEKLDQLREILGLSETDAEYEISLEATPLYQSTALAALKDVLATVKTPEDAWSIMESRRDELLLKKESTKSLLSSMVMQALGGPLEETNKFAKVNNEAATYDHMLRTLEAKEVLISILAKSGWDEFDNFDETFCNPWDKQSANGFLSSDERIKLYKMFLSRSIRKSDGGKISDEMYARIMDVKGLLGITDQQAEIESRAAFGPELQKVLNTAMLEIVEDYTPELAENMKRRANEVVESYRLTQDFLREVGATFYAKAVALVSEKAPGGIPSKELSQALEALRELYNLEMTDCYSYHMEHFGSIYKKSVLEAMGSTGVIRPEFRESLEKLKGRLGVSEEACQALFLEAIQDKMVPMVKWIGSEMERTMLTQKQLAQRRGKDMGEDVFQSGKGADGVLGLGSEVNIMSDIMELVDFYNENDVAKEEERTRTVEKQVEEGGETKLVAVEETYTETVYPVTALAAGNMDQEMAELLYRQFTVGGFTTQGEQGARYEASRETFGGILGLTKEKMDDIKDNIGSTVYDNFISNAMKTKGSMDQQDMMFLANIQTKLGLSPEQGEKMMTQSQKKILSEEIDAIMDDPSPQRVKAFREKCNSMGMDLIADVGISKPRLVRMFEVEVIPGLKTGEINAEQTEIFQEIQESLGIELEECEAMFENVLAQLSKNAFELIKGELLRGREENCVDLIKELVRYADFTEGDLGLEVEEAVGNQVLNIYESVDLGGQSADEIEHNKELLRAAMKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEL6</accession>
    <name>B7GEL6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_41584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185571.1">
        <property type="nucleotide sequence ID" value="XM_002185535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEL6"/>
    <dbReference type="PaxDb" id="2850-Phatr41584"/>
    <dbReference type="GeneID" id="7199414"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41584"/>
    <dbReference type="eggNOG" id="ENOG502T2SH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096071_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEL6"/>
    <dbReference type="OrthoDB" id="52542at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853204" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="254" mass="28686" checksum="D54F6EBD0900712B" modified="2009-02-10" version="1">MQGGFSMVLLFQWSFILGGVLNMAQSIWEALAARTKALAPLVYHFNGLADLQWAQQIREREKSKKKMVKEWNSYQSMSTDSNVSTTASASQLSTLVWHQHLHKYTAHRRSILAAATFYIAALLALSQFSYHQANTSGRARSTLALTITLFSTTGRSTYPRLRVTSEQTENKSHHVLRVWANPEVLEDLCDLSFLIGSLMDSMLDDVRVSAHFDTWAIVSSLLWLIDACLYLQSNFVMASRVKKSHDIKSDSCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEN7</accession>
    <name>B7GEN7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185560.1">
        <property type="nucleotide sequence ID" value="XM_002185524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEN7"/>
    <dbReference type="PaxDb" id="2850-Phatr50607"/>
    <dbReference type="GeneID" id="7199445"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50607"/>
    <dbReference type="HOGENOM" id="CLU_067229_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEN7"/>
    <dbReference type="OrthoDB" id="6352234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="153"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="351" mass="38967" checksum="B62F36A1FD5FAB30" modified="2009-02-10" version="1">MSVPPTESQPRPHEQPLRNRAAAPTNAGSLRDARLLLLGAAFSYVLFFAVNVHKSTILPDVIDDAVLATMGLPLASVPVSSLPSLPGWNPVHVYYGDTSHLDHVLDPRHSRRSVQWLGKGPANGRQWTSQFGQDVAVMKILDFPTGAFFLDLAANGPVWMSNTYVLETHFDWKGICVEPNPIYWYPLSFRSCHVVGAVVGARNMDQVSVLLDPGQMAPSNGIVGDTFDNRNVTQPGLVKPRFTASLTDILEHFQAPAVIDYFSLDVEGAELFIMKNFPFEKYRFLCLTIERAPPELQEILSRNGYKFVHTIRQGVDDLWVHESIYDQAKANLAIRTHEIATKNPQLPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3S2</accession>
    <name>B7S3S2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999270">
        <property type="protein sequence ID" value="EEC42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176212.1">
        <property type="nucleotide sequence ID" value="XM_002176176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3S2"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1600"/>
    <dbReference type="GeneID" id="7204963"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1600"/>
    <dbReference type="HOGENOM" id="CLU_1889840_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3S2"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002860787" evidence="1">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="24605" checksum="5AA5F99E8BBFA13A" modified="2009-02-10" version="1">MRFSGALGLLLTFKSARAFSVLPAPSAATSGKHAFCYPASTVVLTTHLYSLLDNIKSDSYNLISTNNNQGDDVNLSDAYEMFVADLVFSTNNPRVDEVRIGLRDLYNIIIDIQTRVEVSKLAEQRQAVKAASVEQCRTIQARAIETQTNKEEMDHQQVKQSFYKTEITPEICLSYEGLLKTVLPLYRAGDFRNVSILTSITKAQVVAAPALWLEQKWLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7S425</accession>
    <name>B7S425_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_bd1660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176301.1">
        <property type="nucleotide sequence ID" value="XM_002176265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S425"/>
    <dbReference type="STRING" id="556484.B7S425"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1660"/>
    <dbReference type="GeneID" id="7204959"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1660"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_4_1"/>
    <dbReference type="InParanoid" id="B7S425"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF61">
        <property type="entry name" value="NOL1_NOP2_SUN FAMILY PROTEIN _ ANTITERMINATION NUSB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002862905" description="SAM-dependent MTase RsmB/NOP-type domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC42693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="413" mass="45502" checksum="E3C6543B1383E27C" modified="2009-02-10" version="1">MVANGYRVAFALTFVGLIPAFEIARQTDVSRPSGHVILRSMTRTTSLASTRSVATEGTKSTKSQSAGQSDASDDRNARFLAARALITKTGSAAFAVDRLESNKHYSTLSTRDRSFARLLVTTTERRLGQIDEVLRQCQKETKSRPNRVDQFVQAALRIGATQLLFLKVPEHAAVKETVELLRHDPKTTVPESRIKFVNAVLRRISREGDVLLATTDVTQNASPWLVKEWQKSWGEEATRKIVALAMEETPRVLTIKQHPGSQLEKPMGRIKAVAALFEDSEILPQGSVRVNTSPPGSIINWPEYSEGSWWLQDAAATTPAIALYNALSKNGETSVAGLDVVDMCASPGGKTAQLWNYGFASVTAVEVAEKRTERLRQNMQRLNMDCEVVVADGAQWTSQHESLQERGASGQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4I7</accession>
    <name>B7S4I7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_bd1517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999293">
        <property type="protein sequence ID" value="EEC42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176478.1">
        <property type="nucleotide sequence ID" value="XM_002176442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4I7"/>
    <dbReference type="STRING" id="556484.B7S4I7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1517"/>
    <dbReference type="GeneID" id="7204884"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1517"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7S4I7"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14357" checksum="CBBDB0A165F62443" modified="2009-02-10" version="1">MCASTMQHANSIDRGYFLRIGVFLYQDRPLPLTPATTSLNYGTTLWEGLKAYHVTDLKAVVFRPDQNYACMRAGAHEMCLPMPMQLAVQKNAHLLPPVGDGMKLYVRPMLLGSGQQLGLYPSPQVSFLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2024-11-27" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TK50</accession>
    <accession>Q5PYA0</accession>
    <name>EFTS_PHATC</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor Ts, chloroplastic</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tsf</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874416.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TK50"/>
    <dbReference type="SMR" id="Q9TK50"/>
    <dbReference type="STRING" id="556484.Q9TK50"/>
    <dbReference type="GeneID" id="4524591"/>
    <dbReference type="InParanoid" id="Q9TK50"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161249" description="Elongation factor Ts, chloroplastic">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <sequence length="202" mass="23043" checksum="7ACFAF8DC228FCCD" modified="2000-05-01" version="1">MKTEIDAKTVKKLRDETGAGMMTCKQALTENHGDYDKAIESLRLKGMATADKKSSRNTNEGLIYSYIHTGSKLGILLEINCETDFVARREEFTDLAKNISMQIASNPEIQVVSLDDISDLTKIEVRKFENAKDDLQNKPEEIKNKIVEGRVEKSLKKQVLLEQEYIRDPNITVTEYIKQVVSILGENIRVQRFTRYVLGEID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0G1</accession>
    <name>RK32_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein bL32c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L32, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl32</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874436.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0G1"/>
    <dbReference type="SMR" id="A0T0G1"/>
    <dbReference type="STRING" id="556484.A0T0G1"/>
    <dbReference type="GeneID" id="4524558"/>
    <dbReference type="InParanoid" id="A0T0G1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044958">
        <property type="entry name" value="Ribosomal_bL32_plant/cyanobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36083">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L32, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36083:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000276492" description="Large ribosomal subunit protein bL32c">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="55" mass="6254" checksum="CDB1AA64DA66536A" modified="2007-01-09" version="1">MAVPKKRTSKSKKNARKANWKRKGYKAAQKSLSLAKSMLKGKTTSFVYSIYVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-09" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0M4</accession>
    <name>A0T0M4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ycf39</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast" evidence="6"/>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874364.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0M4"/>
    <dbReference type="STRING" id="556484.A0T0M4"/>
    <dbReference type="GeneID" id="4524641"/>
    <dbReference type="InParanoid" id="A0T0M4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05243">
        <property type="entry name" value="SDR_a5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044256">
        <property type="entry name" value="HCF244-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47128">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47128:SF2">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="3 6" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABK20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="319" mass="36849" checksum="926F6860E72B2837" modified="2007-01-09" version="1">MSLLIIGGTGTLGRQVVLQALTKGYQVRCLVRNFRKASFLKEWGVELVYGDLARPETIAPCLKGITAIIDASTSRANEQNSLKKVDWEGKLYLIEAAKAANIKRFIFFSAQNVEQFENIPLMKVKNGIEIKLKQSEIPYTIFRLTGFYQGLIEQYAIPVLENLPIWVTNENTYISYMDTQDIAKFCLRSLQIQETINQTFFLSGSRGWVSSEIINLCEQLAGQEAKVQKIPLFLLKFVSRFFGFFEWGQNISDRLAFAEILNTENNFSKSTFDLYKLFKIDSSEIIQLDDYFLEYFIRLLKRLRDINFEDVQKQKNLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3S4</accession>
    <name>B5Y3S4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_13281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185889.1">
        <property type="nucleotide sequence ID" value="XM_002185853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3S4"/>
    <dbReference type="FunCoup" id="B5Y3S4">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3S4"/>
    <dbReference type="PaxDb" id="2850-Phatr13281"/>
    <dbReference type="GeneID" id="7204660"/>
    <dbReference type="KEGG" id="pti:PHATR_13281"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3S4"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="181" mass="20712" checksum="DFC6CAAF5CBA8CB0" modified="2008-11-25" version="1">MRPLTEEETKSLFLKLSEYIGKNIERLINRSDERHCFRLIKDRCYYISESIMKSATSIGREHLLHVGTCMGKFTKTGKFRLHITALEYISQYAKYKVWVKPSAEMSFLYGNHVSKNGLARMTENTPQYSGVVVYSMSDIPLGFGVAAQSTEHCQQLDPTGNVVLHQADIGEYLRGLEEDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3U4</accession>
    <name>B5Y3U4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_36846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185899.1">
        <property type="nucleotide sequence ID" value="XM_002185863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3U4"/>
    <dbReference type="STRING" id="556484.B5Y3U4"/>
    <dbReference type="PaxDb" id="2850-Phatr36846"/>
    <dbReference type="GeneID" id="7204670"/>
    <dbReference type="KEGG" id="pti:PHATR_36846"/>
    <dbReference type="eggNOG" id="ENOG502SBAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_864539_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y3U4"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="29"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="23455" checksum="98EC4BF8E7B6009A" modified="2008-11-25" version="1">MGQAMRIAKYDRAANERNAVTALTMAGQALSWYRLDDGVMGGKSDTQQHVTEDGVLHFDGTINTEGGGFASIRTMLPPGVLPSTRTAAIRLRVLGDGKTYKLFLTDGTAGGPLSRSPSWQADIPTRNDGTWQDVRVPLDSLLPNFGGGVRRNPNEDKANYTFVAEEMNQIGLMLSLKLSNGEPNPKETFGEGIFPFSLRVQSVEPVDEPEENPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3X2</accession>
    <name>B5Y3X2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATR_46833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185735.1">
        <property type="nucleotide sequence ID" value="XM_002185699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3X2"/>
    <dbReference type="PaxDb" id="2850-Phatr46833"/>
    <dbReference type="GeneID" id="7204687"/>
    <dbReference type="KEGG" id="pti:PHATR_46833"/>
    <dbReference type="InParanoid" id="B5Y3X2"/>
    <dbReference type="OrthoDB" id="46616at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACI65205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="356" mass="40530" checksum="4CBF3BB0F4BF0D97" modified="2008-11-25" version="1">MYRRVLSIFANELSKKCPNKIISDYGLRIGIRYRSLLVTHGTLYTRGPKSKSPVASIRKESNGKRVVDVDWRPMTLQERIKEFPASVKRLWKHYELYGNIHNASKTKRNAWSSDSPHNTPLHQGNIGDNPYPIHHLKNRPGLVPRRQYEQQRQFIEALKLVSPTVLVWILPIVGTIPMVLAVAAPRQLLSRHFHNDFEVAEYARQEFSQRLQHFQTSAKLFQDLFGEPLRSLLLEGNGDAAGPILNALPLLTPFGNPANSRKATIAIDGLSGGYLKSFALSVGVLQSLPRGWAPKILEVLPHSYLRFRIQDLAKRVSLDDSFLLYERHHENNCASLTEEELLDAALLRNLPWPPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4A4</accession>
    <name>B5Y4A4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DHK2</name>
        <name evidence="11" type="ORF">PHATR_37014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185972.1">
        <property type="nucleotide sequence ID" value="XM_002185936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4A4"/>
    <dbReference type="SMR" id="B5Y4A4"/>
    <dbReference type="STRING" id="556484.B5Y4A4"/>
    <dbReference type="PaxDb" id="2850-Phatr13255"/>
    <dbReference type="GeneID" id="7204469"/>
    <dbReference type="KEGG" id="pti:PHATR_37014"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355080_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4A4"/>
    <dbReference type="OMA" id="MWGETNE"/>
    <dbReference type="OrthoDB" id="43115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="381"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="671"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="791" mass="88192" checksum="CF7FF48D5C101574" modified="2008-11-25" version="1">MYYGDLINGICYTAFLPVYFYLWLQEKDLGRRSAASSVVAAFAWTAAFSWLSYFLKKPNLSVMALMGMSSSIYYMNIHQWPHADELVVLPQFLWSLLILSANRPLTFPFQFALAMVALLTAVYVAAKESSQAVLDTLPVLGGATSMHIWFHYYATYLRKKSHGFVSAHVASLVLAGSFAYHASSEIVTMYRSPGYGSQGGYSILRAGFFALVGLAAAGSFQLEMDSKEALERLVDERARELTKQAAHLRVLEHALQASETAIAIVDVSQKVLWSNSSLQELVAVSPVKLQDSNLFKALQYPDDKVVQSFPPVHAITEEIVLRKRHMSVEMTPFPADAKKNNENRFLVALKDMTSQRARERAEKAAEREALIAQTMNESMQNLSHELRTPLQGIMGMASLVLDEPGLPPDVTESMSMVIASARLLLTLINNMLDVRKCDASMLDEFQLTPFRLVSSLEDAITFCKPFAITSEVKLDLEINDDEMEVESNDLRFPQIMINLLSNAIKHSCSGDQVIIRASSMELSEAEQLVDRALVIAPGEPSSKAFRKEDGPVAVVTVTDQGPGIPFDQRMRVFGRFSQLTENVQNAIIGSKVGQPSGTGLGLNLCMKFVHRMNGRIWVTNNPEKGCSFSFYVHRVLQYDRMREVSLPRTWSQSIHQVLRPVPRIPLTKEFRIVLVDDTLINLKVLSRMLSRLGVQKMATANNGKEALDLLTTEDDFNLVLTDIQMPEMTGIELSLAIRKLPLKRQPLIVGLTADTSDAGDARCTQSGMATILRKPITTNQLHHFLQEVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4F7</accession>
    <name>B5Y4F7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_43822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186285.1">
        <property type="nucleotide sequence ID" value="XM_002186249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4F7"/>
    <dbReference type="STRING" id="556484.B5Y4F7"/>
    <dbReference type="PaxDb" id="2850-Phatr43822"/>
    <dbReference type="GeneID" id="7203956"/>
    <dbReference type="KEGG" id="pti:PHATR_43822"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815003_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4F7"/>
    <dbReference type="OMA" id="NEFSANA"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37127" checksum="F22E58433D9D91DB" modified="2008-11-25" version="1">MVRHHTKNKHAPKNQAEQAVADAKQLDRFAGSSEESAAEDDDVSVGVPNATSPIHAQESLLLQSNRPTATTKKPANDREIDNVPPREEYSADEESKVESEHDDDGDAILTKSAGMASAMSRILGTDEGPGSSKTTLGAKPVVLAKTTTPLQRQAAREKESVKAAQEKRRANRERTLQACHVPLSVATTSHVDDSNNAGAALVQELEQERSHRRVATRGVVALFNAIAQHQHQVVEPEAPSSQISNKKDSVKKLTKHGFLDMIKSKAAAQKEDDMAKTSKGGPDSRRTTASDAEKPQWNALQDDYLMNPKKNWDQEDSSEEDGSGNESKQRPGPPKKARKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4J4</accession>
    <name>B5Y4J4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_43853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186304.1">
        <property type="nucleotide sequence ID" value="XM_002186268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4J4"/>
    <dbReference type="PaxDb" id="2850-Phatr43853"/>
    <dbReference type="GeneID" id="7203974"/>
    <dbReference type="KEGG" id="pti:PHATR_43853"/>
    <dbReference type="eggNOG" id="ENOG502SPDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050458_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4J4"/>
    <dbReference type="OMA" id="IEPARLC"/>
    <dbReference type="OrthoDB" id="202710at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838783" evidence="2">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="392" mass="44155" checksum="AB6DBB6F9598AB4B" modified="2008-11-25" version="1">MKPLPANQTIVFLCLLPLANGFASRGSRRASPATRQYASADGNGTPRVPQWHLSNDFETFLNQRTIQSFLFLVKSLRDPQTVLWVENFTQPALHSGRSSTYTSHLQSGSSSSQLLSYHGLAAMNVTRFPTWDIYFKELLKQPTVIYTVESESKHIQTYDMEINPGRLCVRMLAVRQQIAQEFARDLDVVATMGGHTLEAYWESLRASRRTPSAADNDRDIVGNYTSGTNLVFLELHPDPTSDYAPSPLRQGNFDLLVLLATQEAVHRVLNDPARQTGVTKVTNDYLCGFYEQRLDTHFTGGQRYHRAADFLAELLEAPPLLRSVSDGNTALLDPTFMAELLLHQREKVAKEWQLLVQAASEVHMEIQRLQLNRLMSVNTEQSGVHEEQPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4L4</accession>
    <name>B5Y4L4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab proteins geranylgeranyltransferase component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_43871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186032.1">
        <property type="nucleotide sequence ID" value="XM_002185996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4L4"/>
    <dbReference type="STRING" id="556484.B5Y4L4"/>
    <dbReference type="PaxDb" id="2850-Phatr43871"/>
    <dbReference type="GeneID" id="7204288"/>
    <dbReference type="KEGG" id="pti:PHATR_43871"/>
    <dbReference type="eggNOG" id="KOG4405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4L4"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="73474" checksum="EE7147A4BAEF2224" modified="2008-11-25" version="1">MVDQTALPKTSGASRHLDNDAPRDEEGLLLEYDAIICGTGLTQSILASALARHGKSVLHCDTSDYYGELDAVWTLPYLQEKLGKGHELKGKMVTVRTDDSTCIPLSPKGGLQSFQIHSLERRNDFTVEQGTAVVTPYGNGTIISISPRGLFLDLLVSLDTWKLANGKNPSVHISIPQSAASTGAAFQKYLKEKLGIVSIDERDAHLILDERSRGFAVDATPGLLYASGASVEGLLKSGVADYLEFKSLEGLLWLENSDSCLEPVPCSKNDVFASKLLSPMDKRRLMKFLQLALDYGTAHALAEEEASAENNKQVLSLNERYLNQGRSLARPQNKAVLADDIRALQEFIQADMKFHEYLESKQRLSPKLCRIVRHALALESGNGDWSLRQGMTSLCQHMQALGRFGTTAFLVPMYGSGELPQAFCRSAAVYGATYLLRLKAAAIATDGEASAAMVKEVMCRHMVVPQDSVATLESKSRRVWRYLCIFRGKVVGSSRSPQRHAIIVPPGAFGPDAVRGVLLDEGVNVTPHVPCGCTILHLTMAVENDTGIDPQDILRRVSLSVLSSKYEGSNAIRIFQVTFSYALPEASNQTKNVQNLHCVQRSEPGLSADSSFEQAREIFAAICPDGNFLAISEQVDTVVKERLGEQIEEDADGLVLDSAMDIIEPKTRESSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Q5</accession>
    <name>B5Y4Q5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene desaturase. zeta-carotene desaturase. bacterial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186335.1">
        <property type="nucleotide sequence ID" value="XM_002186299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Q5"/>
    <dbReference type="SMR" id="B5Y4Q5"/>
    <dbReference type="STRING" id="556484.B5Y4Q5"/>
    <dbReference type="PaxDb" id="2850-Phatr43904"/>
    <dbReference type="GeneID" id="7204310"/>
    <dbReference type="KEGG" id="pti:PHATR_43904"/>
    <dbReference type="eggNOG" id="ENOG502RYSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="InParanoid" id="B5Y4Q5"/>
    <dbReference type="OMA" id="FDFGPNT"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="696" mass="76416" checksum="92E1389817373ECA" modified="2008-11-25" version="1">MQSRVCHFRFRWDPSGDPSKIRNLVMRSRQSSRRPGHAHEKGSARVTQTAGLFAMRDALGILALAWCSRSRNSCSSSIAVGSFASPLSPPPGRNRATQRQLVVAHQTNSQQSVVGGSTRKSRRVVVVGGGVGGLATAARVAVASPSTEVIILEKNDFVGGRCGSFNVDVPGKGTFRHERGPSLLLLPHVYREIFEYCGSTPEENGLEMKQCTPAYQVVFSDGDCIQLGFPRASDKVERSEEELKSRRKMDTFERNGAAKWDAYMKTCEAFLDCGLPNFIEQRLDMKSFPAFIREALRDFGKGWPLKPHSDVLDSFFESDKMRAMASFQDLYVGLEPYRNNQLLGGGVLTTTAPAVFGLLAAIELHPTNAKCGVYAPIGGFQAVSLALEKLARSCGVKTLTGRAVSEVTDEGVFYVETQANATETKFLSADLVVVNADFPYATQSLISKSETRYSPRFDWDDRFLYSSGVIAFHWSVGRSLDDLYTHNVFMVSGSRKKVEESWSVLRDASTSSFDFEDAEFNFYVHRPMATDSTAAPQGLDAILILVPCPTLLRDPANMHLSRDESIAAYKNQISEGSINILRRKVIQRLTAIPSLATFGSDDILDEHVDTPGTYADRFHCGAGSPFALSHGFKQLSLARPGPTSQKHHKLIFTGASVRPGNGVPLVLIGAKGAEEAILSKLRDTSKDVQWESKNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5H1</accession>
    <name>B5Y5H1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_44139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186468.1">
        <property type="nucleotide sequence ID" value="XM_002186432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5H1"/>
    <dbReference type="PaxDb" id="2850-Phatr44139"/>
    <dbReference type="GeneID" id="7204055"/>
    <dbReference type="KEGG" id="pti:PHATR_44139"/>
    <dbReference type="eggNOG" id="ENOG502SD0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1430606_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5H1"/>
    <dbReference type="OMA" id="FIASAAC"/>
    <dbReference type="OrthoDB" id="202789at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002841279" description="C2H2-type domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="190" mass="20652" checksum="F677C0F35FC6A7D0" modified="2008-11-25" version="1">MLKATKCFALCSLIYLGASAFIPHAILHQENRPIYLSAFLHTNGQQSDTRRSLTIGSAATILASWGIPFSAHANTGAEIRGTEITPFNGLAFQYRGSDFGGLKAEDLNEPSVPYSDFVQRLKAGEVEFVEFMAPSGDAAYVTFKGKPPIRIGEGYPIEQPNGWSSPAFAVRTVKDAGVPYKFTIPALRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNS1</accession>
    <name>B7FNS1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176584.1">
        <property type="nucleotide sequence ID" value="XM_002176548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNS1"/>
    <dbReference type="PaxDb" id="2850-Phatr42564"/>
    <dbReference type="GeneID" id="7195950"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42564"/>
    <dbReference type="HOGENOM" id="CLU_1550525_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNS1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="210" mass="24114" checksum="FC88D44562BC6759" modified="2009-02-10" version="1">MKIIAQRTICSLHRIAPRSVGFSSSRSVFSASQAEDIMTSGGQRQGCRYLHQSVNVRPMDMSNLHSWSEAAYFPDPKDLKVNNEGDLDASQFGYRVVPLSQECVYTSTMSVSSYDDYDPVEDIDEPYDNFYDEDNSLEVSRDNIDVSSSAALDTIEAHREWDKLLAEEADHPPHFECLKEDPYLEDRETYDNVWNELHTHDLEHVYLGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNS2</accession>
    <name>B7FNS2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_42565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177089.1">
        <property type="nucleotide sequence ID" value="XM_002177053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNS2"/>
    <dbReference type="STRING" id="556484.B7FNS2"/>
    <dbReference type="PaxDb" id="2850-Phatr42565"/>
    <dbReference type="GeneID" id="7196265"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42565"/>
    <dbReference type="eggNOG" id="ENOG502S3KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_659667_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNS2"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855220" evidence="7">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC51552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="417" mass="45809" checksum="06FA4E240EF3E5E6" modified="2009-02-10" version="1">MYLRPSQWLIAALCLVRVHSFGGLEAIPFAAVDHHALTHSLTIASGSSFEAFTSSTNTLASSLLTAYTDTLATYPLPTKVATGASLAVVGDAIAQSREPDAYDKRRAASFMMFDMAYRATQHALFPIIVLQCHGQFLMAPIVALSPWWASFASLDALAAMERTLASQLGIVPFLYYPVFFALTGAVQGLSLDGAINRAKENFIPLMKRNLLFWIPVQFVQFGFVEENLQIPFLSVCGLCWTFVLSVMAGSTKNYNQEESTADSTVTTRNPVTVSTNGATSQSLPTEDRYCVTGFEEGCHLPDDLFPHTTLKDVSHELEHMADDFAHELVEIADEVAHEIHDLAELTEEGWHEITEFAHLERKSQASAKVDKSEMTDGGISNRESSMIDMETGSASTKETSVAKAVQEDKELTLNQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPM6</accession>
    <name>B7FPM6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176740.1">
        <property type="nucleotide sequence ID" value="XM_002176704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPM6"/>
    <dbReference type="STRING" id="556484.B7FPM6"/>
    <dbReference type="PaxDb" id="2850-Phatr42809"/>
    <dbReference type="GeneID" id="7196420"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42809"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861838_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPM6"/>
    <dbReference type="OrthoDB" id="46139at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35687" checksum="EE1D2ACA01EFAA08" modified="2009-02-10" version="1">MVASHESEGSMASVAPTAKIDKDISRPASPRDVACSSMEMLARSMEPSSKSFLPTAKPFFVMDWLDRIDEKDLELARQIITTPGRALLTDFGKETSTRTVSLAGASRKDFAGEPSKPSEHPPKQKFTPRSHFRKRGIAVGNGWNAKGLQKAKEGNWEDALSCWENALEIRSQVCLSLVDVANTCNNIGIALGKLNRFDTAVEHLERALEVREALAEGADNQAEIATTLHNIGNVYQQAGEFGKAEEYFVESRDMQIKVLGRDHIHVARTLAALGNVRYQANRIPEARKAYWEALTIFQHVGLPEADIEVQCVLGNVQEIDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPU8</accession>
    <name>B7FPU8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_8963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177278.1">
        <property type="nucleotide sequence ID" value="XM_002177242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPU8"/>
    <dbReference type="STRING" id="556484.B7FPU8"/>
    <dbReference type="PaxDb" id="2850-Phatr8963"/>
    <dbReference type="GeneID" id="7196452"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8963"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617481_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPU8"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF121">
        <property type="entry name" value="OS09G0315000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26030" checksum="8129396A369E8AF7" modified="2009-02-10" version="1" fragment="single">MDPEWKDLKKKLFNGTLLAVSFGFVIFTVLNIDHGMTRGWTQSEIAMRIPLDNWANYESSLEEKPIFTKTLINVVIYLLGDWLSQTLFQKKNVLDFDASRTLRNGFIGLCFGPLVHEYYQFSDHILPVEGGIWNRVEKILMDQTIYLTVKCSVYISAVGLLQGDDWSTVKQTVKHRIGGIVFTAWKFWPLVHCITYSVIPAQHRILWVNSVDLIWNAILASMSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ36</accession>
    <name>B7FQ36_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_42942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176812.1">
        <property type="nucleotide sequence ID" value="XM_002176776.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr42942"/>
    <dbReference type="GeneID" id="7196775"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42942"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002963_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ36"/>
    <dbReference type="OMA" id="ALVWTSY"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="276"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1474" mass="165432" checksum="68B8A3F930403DCF" modified="2009-02-10" version="1">MSLSLGVASPEQPVASVTKTLAKLCSIASNRSCADCRVTLIDSSQVHASFNPKIELPSSQYNNFRLNHVNFAPPNYSPSKIPETLDPPVDPSLVAASYVGGHGVFVCALCGAAHKLLGRSITVVYAVQDSSTWSVEEVQLLVKGGGNNRARSVLEAHIPHSWKQKRPNADSTIADRLTFVRAKYEALAFVLPPSGPFANRAWRAILDRHQDEWEGNWGADLHSFSELQLGESHSQRASRNLMQSVENGNRESILPNRLVDYFCVVTPSEFVIPDMLGLDLSELSSPEDVLLVPEVTDCFPNQEAHADTEFPKHIGSLVVPDGCRPSLTPRPPSFFSFVLTCGDGVRLYGGALCLYDNDSDVENLKEKFRISGYEGQLPGWMGSERSRLVHDQDTRSSSFQSESDVYVDVVYFPKVLVVVSHYPFFDVWRKFLLQIYRIALVGAPLPIERFIANFVGEVPLPPPGKILVKFGLTVNDTWSIGRPPENQLPLADFSFQPLFAALSVSNVMVVIGCLLEEGRVALLSRHYAMLAPTAEALVSLLFPFHWQGMYLPVLPYNMIDILGAPVPFLVGLHSRYLVDVPAGSRPRGVVFVDLDRDVIHLGYEYDEVTPRSSPALPERQALKLKSKLETHASVAYVECDSVFSAAATKAATILTGNEEELHNSYRDPYARASKSESCPTSVRRKDIFGRLDRAYADNELQVPISGFLSEHGQFYEQDASSTPDSKGQRFKFLRAVRPRGGLKSKISADSSGSERFHVTGSPGTKLLDKDDPSGFDSSEIRNAFLRLFVSIFQSYRHYLDKNGFRSEAFIDSLNCSERSSEFLHCVVKTQFFSRFLDERIQNPSDPEIRFFDESIIAKINRSKKQTFSKIGRGGGKRETSFLKDDSNMVNETFTPPPPSNWGLPDDGRTYHYGSFPALNPELFGKVRRPMKWPRYDQRSSVRTSRRISALAQANEKAFVARALKPVSKTPKMLMAETKRGVKNLDTALSALSSPFVPSSPMRETNRERRATGSSDFSMSDISLSSALVMRDDIVSTAEGVVLNARRKQAILLGIIIKLQTHCRLHLVLKKDHQRESFRVSAEGDRSNLETNAIICLQKWYRVLSVGRSTREWFRKLRFATCRMQSLTRDRMVRAGFLLLVTAICRAQARIRGFQTRKIVASIVEHRLRTYREHIFLLWKASHTPLSYRCKFWPILKVESYLRVQMAEAEVHRLWSKLNIPLPTSMKNLSTEQPKIVKSASLLRMNFETHWACIILNIEKPILILDFSQKGNSKVTAGPEAQRINSERVQIYDRISALKLEQQLALFDRFSVPLKGKRKKLALAVSIWHATKLADESTALMLTLFTELNDSTNINFKAPTKKSLRRFPPSPAITPLKRALWAHVALEDRIRLNTLEVARIGLHDIPRLSHKVVGNNAVQTSGKNRLELMRRVLNCGASGVNTGETKSLQARHLFKPPAMFNRSHASKSDSIREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ72</accession>
    <name>B7FQ72_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondria-targeted chaperonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CPN60_1</name>
        <name evidence="7" type="ORF">PHATRDRAFT_24820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176830.1">
        <property type="nucleotide sequence ID" value="XM_002176794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ72"/>
    <dbReference type="FunCoup" id="B7FQ72">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQ72"/>
    <dbReference type="PaxDb" id="2850-Phatr24820"/>
    <dbReference type="GeneID" id="7196793"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24820"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="InParanoid" id="B7FQ72"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="579" mass="60928" checksum="547413C4B5F70802" modified="2009-02-10" version="1">MLSSSISRAASRSLTGRTNLTSVRGFAKQIKFGVEGRAAMLRGVDTLADAVQVTLGPKGRNAIIAQPYGPPKITKDGVTVAKSIDFEDKFEDMGAQLIKSVASKTNDIAGDGTTTATVLARAIYSEGCKAVAAGLNPLDLRRGIQLAVNSVVKTLGEISRPISSKAEVSQVGTISANADREIGDLIADAMERVGKEGVITVQDGKTLENVLDVVEGMKFERGFISPYFITDAKTQTCELENPMILLVEKKVSNLQQLVPLLESVIKSQSSLLIVAEDVESEALATLVVNKLRAGIKVCAVKAPGFGDNRKATMQDLAILTGGTVISEEMGMKLEETQPHHLGRCKKVTVTKNETVVLDGAGEQASIQERCELIRNGIDTTKSDYEREKLQERLAKLSGGVAVIQVGGASEVEVQEKKDRVVDALNATRAAVEEGIVPGGGKALLYCSTKLDEVAEKEAINMDQKIGVEIIKRALKAPLATIVSNAGEEGAVVCGELIKPDVAVTWGFDASIGEYRDLVEAGIIDPTKVTRTGIVDAASVAGLLTTSESMIADKPDDGPSMPPGGGMGGMGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQD7</accession>
    <name>B7FQD7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177383.1">
        <property type="nucleotide sequence ID" value="XM_002177347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQD7"/>
    <dbReference type="PaxDb" id="2850-Phatr32160"/>
    <dbReference type="GeneID" id="7196234"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32160"/>
    <dbReference type="eggNOG" id="ENOG502SVFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1558376_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQD7"/>
    <dbReference type="OrthoDB" id="3700at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852551" evidence="2">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="20410" checksum="6192F11B85895FE7" modified="2009-02-10" version="1">MRILFVSIFVVAALSKANAFTAVSRSQTLASLAQGGVLADCRATSIRPLRMADEKDEEFWRQQKVLIREMSGATERAIRAEQKQKFAIRRNALVSDTAFIGFFIFCSLWSVFDNPFVAFSYAFGASLGLAYAYGLGKYVESIGVVSFDAPEPGDGVGQARLAFLFILFIIVGKFRAQGLLELPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQE9</accession>
    <name>B7FQE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MARK3</name>
        <name evidence="14" type="ORF">PHATRDRAFT_8773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176859.1">
        <property type="nucleotide sequence ID" value="XM_002176823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQE9"/>
    <dbReference type="FunCoup" id="B7FQE9">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FQE9"/>
    <dbReference type="PaxDb" id="2850-Phatr8773"/>
    <dbReference type="GeneID" id="7196841"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8773"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQE9"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC51322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="511" mass="57111" checksum="22F07AF7E2020514" modified="2009-02-10" version="1" fragment="single">MDQAPVQIGQFILGKNLGIGAFGKVKLATHAVTGHKVAVKILNKNKIKQLGMEEKVHREINILHLCTHPHIIRLYEVIDTPTDIFLVNEYVSGGELFDYIVSKGRLSADEARNFFHQIISGVEYCHFQKIVHRDLKPENLLLDANLNIKIADFGLSNLMRDGDFLRTSCGSPNYAAPEVISGHLYAGPEVDVWSCGVILYALLCGSLPFDDESIPNLFKKIKSGMYSLPTHLSQLAKNLIPRMLEVDPMKRITIAEIRLHPWFQHKLPPYLRHPPELMEKQERIVDQEVIDEVMKLPFHKAYGNTKGLANGTLNDLRCAYELILDHKHTRLRVMEVARAIQEAASATPPAFSPGGSRGTTPGGHYGTGGSRYGNTGMIAQHQHGRRTRRWYLGIQSKKDPAHVMTEVYKALMSLGCEWLQLSSYRIKCKWRPNTGGSGSSSTIPLAGVIAGEDGHSLRVPNLSTSEYSIKIGLTLYKVQQNIYLLDFQKMTGDAFSFMTLCANIITELKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR16</accession>
    <name>B7FR16_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_43223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176967.1">
        <property type="nucleotide sequence ID" value="XM_002176931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR16"/>
    <dbReference type="PaxDb" id="2850-Phatr43223"/>
    <dbReference type="GeneID" id="7196948"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43223"/>
    <dbReference type="eggNOG" id="KOG1731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458915_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR16"/>
    <dbReference type="OMA" id="LKQGVFM"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="73"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="357"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="595" mass="68477" checksum="0D65D6B71D4E54EF" modified="2009-02-10" version="1">MRMTVLSRRLFKRLRPDRILRIYPKHVPLQWWRCCCWWGCYLLLMTRSAVTISASSLSTDERYLYYAQDVDTSPVIEYMPDADAADPNHPDFLYRPQAHGPRIVEFYAHWCPHCRRFRDHYVQFAGQLVAMAKDQKVEPPLRVYAISCVAHKAICRDQGVKGYPSLKVFPAYSLNATAEPSYFRLHPFSVLGSMGIDFDVDNHAQFAVADTSMTAASAAVTSHTHSSFLRRNWFGSLTSTTDGTLRERQTHVADLDSTRRTKQNVFDDAYRSFDFAIRTAVFMTNGPLEHNATRDALHDWLSLLQKATPPTWSTLQKPVRALLGNFDEIVRGEDHLLAVYEKVASPPASHQWSDDCSHGQKGAGYTCGLWQLFHIVTVGATEWNLMLLEENSPNLLDLTDTADTFRNYVQHFFGCEVCRLNFVSAYDACAHDRCHRLDPTDQSRTAWIQLPLWLFETHNAVNARLLREQAEREGWNVTLADQRAREFPSRHACPVCWKADGSWDEDMVYQFLRLEYWPEDSVAVDLREQLAQRIRVQQEGWDSQRDPNDPDDDRNVPVPPVALQLVPLMVVVGLVAAWYTKRNERLRTGRHKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRM6</accession>
    <name>B7FRM6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="7">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHATRDRAFT_24374</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-binding protein that binds to both double-stranded and single-stranded DNA without significant sequence specificity to reversibly repress the transcriptional activity of chloroplast nucleoids by promoting DNA compaction and possibly regulate DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O = sulfite + 6 reduced [2Fe-2S]-[ferredoxin] + 7 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with ferredoxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Plastid</location>
            <location evidence="5">Chloroplast stroma</location>
            <location evidence="5">Chloroplast nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="7"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177074.1">
        <property type="nucleotide sequence ID" value="XM_002177038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRM6"/>
    <dbReference type="STRING" id="556484.B7FRM6"/>
    <dbReference type="PaxDb" id="2850-Phatr9538"/>
    <dbReference type="GeneID" id="7196698"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_24374"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_3_0_1"/>
    <dbReference type="InParanoid" id="B7FRM6"/>
    <dbReference type="OMA" id="WQMMLRL"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016002">
        <property type="term" value="F:sulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000008">
        <property type="entry name" value="Sulfite reductase [ferredoxin], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000014">
        <property type="entry name" value="Sulfite reductase [ferredoxin], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011787">
        <property type="entry name" value="SiR_ferredoxin-dep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02042">
        <property type="entry name" value="sir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0883">Thioether bond</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855241" description="assimilatory sulfite reductase (ferredoxin)" evidence="17">
        <location>
            <begin position="22"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="19">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="18">
        <location>
            <begin position="204"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="19">
        <location>
            <begin position="406"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEC51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="633" mass="71419" checksum="E5F49EA77CD31F3A" modified="2009-02-10" version="1">MKFSSSAAAALLLLQSYSTTAFSFHPARVTSRRQRTSSLSMVLEKPKPKKLPKIEQLKIDSNHLVHPLIEQLKTEEISISKDAYQILKYHGSYMQNNRETKGPKDYQFMLRLKQPAGELPPDLYRLLDDLSREKGQGDLRATTRQCFQMHGILKGSLKEVIASIMNIGSSTVGACGDVSRNVMTTPAPFAHPAYEHAREWSKVFAQLFRPMTPAFSQIWLDGEKAATVESWHTEVSGYNIDEVMKHDTGRGVVLNDSVEPLYGDRYLPRKFKIGVTVPGDNSLDIYTNDIGAVVITDSAGNLEGFNIMVGGGMGRTHNKENTFARAADHLGFVSKEDAMELMKCIVATQRDHGNRDVRANARMKYLVHTLGIQDFRKLVESYFGKPIEPWRPMVEWKYSDWMGWWEQGDGKLFCGVHIENGRVKDEGKFRLKTALRRIVDKYNIPMILSPTQSIILRDINPNDKKGIEYLLDAHGIKPIEHVDPLNRLAMACPALPLCGLAQTEAERLMPAYLDRVRGLLNKMNLSDEEIMIRMTGCPNGCARPYMAELAFVGDGAKSYQVWLGGSPVLTRTAWPFMAKMDVDDLEKTLEPILAMFIQQRQQFEAFGDFCYRVGAEAIEAYSNNYRLGSVRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS56</accession>
    <name>B7FS56_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177607.1">
        <property type="nucleotide sequence ID" value="XM_002177571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS56"/>
    <dbReference type="PaxDb" id="2850-Phatr43410"/>
    <dbReference type="GeneID" id="7197140"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43410"/>
    <dbReference type="eggNOG" id="ENOG502SVBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609014_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS56"/>
    <dbReference type="OrthoDB" id="47453at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855258" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="2">
        <location>
            <begin position="206"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="459" mass="50145" checksum="0EC5DF5FCD15DB43" modified="2009-02-10" version="1">MNLKVISTVFAAMVAGAASDTQVADTENRELTFTKPGKCKVTNLDFSTLHKNTYVHPLALLKFGVKKVYTKSTSKKCRTPFPAVIDTSNPICDPDLKSHYGNALVVQENDHVVRDKCYLADDCVAGGQIVFEFLKKVNLKKIVVLDMDEAVTVTIKTAAGATKVFHPDRPGNGKHVELKLNVDGAVFMEVDFDGSGAVPLIVYDNCEPGGNGDPHFQTWTGHKFDYHGQCDLVLIDAPNFEGGKGLDLHIRTEQRSFFSFINGVAMKIGNDILEFSHQQVFLNGADQTGLAAENEMKFAGYPVQYSNKPLANGRDHNTYTVNIGPSERIQVNVYKQLMAVRVMDASHDNFIDAVGITGDYNSGLTLGRDGTTIIASPDLFGPEWQVNDQDPKLFATVQEPQYPAKCIAAPAADSKPRNLRHGISEKQAKEACAILGDDIEDCVFDIMATGDIEMVGAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT65</accession>
    <name>B7FT65_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_1990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177787.1">
        <property type="nucleotide sequence ID" value="XM_002177751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT65"/>
    <dbReference type="STRING" id="556484.B7FT65"/>
    <dbReference type="PaxDb" id="2850-Phatr1990"/>
    <dbReference type="GeneID" id="7197003"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1990"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="B7FT65"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="252"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="42684" checksum="1DECEA86F4B5F40A" modified="2009-02-10" version="1" fragment="single">RLKVIQADTSSHLSSVKTFQELNLPTHLLEALFTMGFDRPSAIQEEALPRILADPPRNLIGQAKSGSGKTAAFTLGMLYRITVDTPATTQALCVTPTRELAIQIVDKAVRPMAVNMKGLKIQLAISQSVVDKKIGVDSHMVVGTPGKVVDWLKRRIINPDTINIFVLDEADNMVEEGGHRANSLLIKKCIPPTCQNLFFSATFPEEVVNFATKMVDNPDKILIEDGPEFLVLDVIKQLWVDTREYSGGKLMFLGDIYSLLTIGQSIIFVGTKIDADTVHTTLTGAGFTCSVLHGSVDAAQRDTTMEAFRNGESNVLITTNVLARGVDVDNVCMVINYDIPVDKDGAPDFETYLHRIGRTGRFGRKGTAINLISDQKSVEILAAIESHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT72</accession>
    <name>B7FT72_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_41766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177790.1">
        <property type="nucleotide sequence ID" value="XM_002177754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT72"/>
    <dbReference type="PaxDb" id="2850-Phatr41766"/>
    <dbReference type="GeneID" id="7197246"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41766"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_0_1"/>
    <dbReference type="InParanoid" id="B7FT72"/>
    <dbReference type="OMA" id="RSNEDEP"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="39569" checksum="9FB2CE24850C0215" modified="2009-02-10" version="1">MSVLVHGIAGQTTDDQTDANARRHRGEFVRGVSTARNWVTDDPNAVFPVEMDRYHLYVAYNCPWCHRVLLGRALMGLQDAITVDVLFPNRSNEDEPMGPNLWKFEPEGQVGQNGVHVSFPSCTRDTVLGKKYVPEIYQASGVEDQKSVPILFDKKSKQIVNNESAEILRMLGTVFGRLGSRGTPLLNLYPAERIKLIDEQNDWIYKDIANGSYKAGFSSNQEVYEKAYHTFFEGMDKLDEIFAQQTFLTGEAVTEADVRLFPPLFRLDPIYYSRFKLNKAYLWEYPHIWRWMRSMMTLPDMDEVTNSEYLQHCKQGYFGRTGNGTIPVGPPGYPESYKEKHPTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTA2</accession>
    <name>B7FTA2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mg-protoporphyrin IX chelatase</fullName>
            <ecNumber evidence="9">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_50740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>protoporphyrin IX + Mg(2+) + ATP + H2O = Mg-protoporphyrin IX + ADP + phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60492"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.6.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Plastid</location>
            <location evidence="9">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178119.1">
        <property type="nucleotide sequence ID" value="XM_002178083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTA2"/>
    <dbReference type="SMR" id="B7FTA2"/>
    <dbReference type="STRING" id="556484.B7FTA2"/>
    <dbReference type="PaxDb" id="2850-Phatr33017"/>
    <dbReference type="GeneID" id="7197023"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50740"/>
    <dbReference type="eggNOG" id="ENOG502QU3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_6_2_1"/>
    <dbReference type="InParanoid" id="B7FTA2"/>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011776">
        <property type="entry name" value="Mg_chelatase_ATPase-dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02031">
        <property type="entry name" value="BchD-ChlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43473">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43473:SF2">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="9" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852606" description="Mg-protoporphyrin IX chelatase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="592"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="800" mass="86572" checksum="E819DA7B5188BB11" modified="2009-02-10" version="1">MVSSSKSTWMMAGACLILMAFQVQSFTFVPATRATSTVKRVAPAFMSAVADDKSETSETEAAARARLVMEAEAAMNGGSSKIGIKDTKLMDLGGRPFPLSMIVGQDSIKQALLLSAINNRMGGVVISGGKGTSKSVMARALHQLLPPIEILKDSAFNIDPEGEFGLDDFTRTEIDNGGTPLADRETEIIPCPFVQVPLNVMEDRLIGSADLEESVKSGKTVFAPGLLAKAHRGVLYVDDINLLDEETANILLNVVSDGYVLVEREGISLRYPCRPLLIATFNPDEGELRDHLLDRIAIALSTNADRLDIGQRVDAVESVLDFASSGKQKTDKAEVALQEAIDNEDDLKTAIVFAHEYIKDLKVAPSQMQYLCEEAIRAGCQGHRAEIFACEVARASAALEGRQVTSEDLRLAVKLAIAPRGTFINTPMDPDEMMPPPPPPPPPPPQMDDQSQDQDEDQEDDDEQPDEKEDEEEDEDREDEAPDVPEVPQEFMFDIDATPMDPDLIDFTSRERSGKGGGRGLIFSQDRGRYIKPMLPKGKVIRLAVDATLRASAPYQKSRRERAVGTSKEGRGVHIQQSDVRIKKMARKAGSLIIFVVDASGSMALNRMNAAKGAAVSLLTEAYQSRDKISLIPFQGEMADVLLPPTKSITMARQRLEQMPCGGGSPLAHALQLATLTGINAQKSGDVGKVVVVLISDGRANVPLCVSMGEEFDPESDEDSKDGKPSRSYLKDEVLACAKRLGSQGGFNLLCIDTENKFISTGLAKEIADAALGKYHQITKADGKAIASVTSQALNQIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTB2</accession>
    <name>B7FTB2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubisco accumulation factor 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178124.1">
        <property type="nucleotide sequence ID" value="XM_002178088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTB2"/>
    <dbReference type="PaxDb" id="2850-Phatr43743"/>
    <dbReference type="GeneID" id="7197028"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43743"/>
    <dbReference type="eggNOG" id="ENOG502S9NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1153707_0_0_1"/>
    <dbReference type="InParanoid" id="B7FTB2"/>
    <dbReference type="OMA" id="CWEEENE"/>
    <dbReference type="OrthoDB" id="194277at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040858">
        <property type="entry name" value="Raf1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18087">
        <property type="entry name" value="RuBisCo_chap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubisco accumulation factor 1 C-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="197" mass="21359" checksum="F812AF150F43D9AD" modified="2009-02-10" version="1">MSWSPARLSATATDNGGSIHGQNSCFLPLRQLDQDYYAPRIVQIAGAYPGLTKEEFYGVQSEEAAEVGQWSYDFSDPEGPQVGTVAMDGSELVSFCPDPVAIIAEHSSVGVDLPKEITEPVDLIVLVDRSRKGFSERTFLVVDTPEEGVLIRAYGAKVEIPDGSEILGQVLLVQIPWLPSMAPTKTGFMEADEYFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUK2</accession>
    <name>B7FUK2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178612.1">
        <property type="nucleotide sequence ID" value="XM_002178576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUK2"/>
    <dbReference type="PaxDb" id="2850-Phatr44582"/>
    <dbReference type="GeneID" id="7198088"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44582"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544555_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUK2"/>
    <dbReference type="OrthoDB" id="49274at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="501" mass="56370" checksum="715DA8511B3A6B81" modified="2009-02-10" version="1">MNLTECDERGADCKDRRASDASKSSLGAVSMDDENPLMTLVDAAASILGTKVARREVSVPGSPLGPQINVCSDAKASGLTVKESPNVIPGTKEDLFGSSSIKLTFAEQLFDILQNEENHDVLQWMPDGCSFIIVNHKKFILDKMPKLFNIRNMSSFVRKLGRWGFSRVHEKATRNSDIFRHPFFVREMREECRKKVKCIGRIPSSSNSKPSVGQVNGVPYKQHLYSVLHDRHLDDVCPRYGDRSDVPRSTSQPMSNLSEGSRSSLYRDDLLPSQGVHLTQSSPNRVTFLDEHLHRVLPELPFSNKSLLPSGLPANLPLFNKSKNSDLQYRGKEGVFVKASATSETSAAALFSQYEKQLQEHQIKRSSLASQLSQQSAYEEARWLSELDHQLAEQQVALEQRRVALEQQRIIKQRQVLMEQRQAMEKRFGGQVFDPRYSQATKGTGSLQEESRGNDNLTSSIADNLQRGRDGVCFTPNMSRKEAIRALLWEERELGFTGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVE0</accession>
    <name>B7FVE0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF839 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178914.1">
        <property type="nucleotide sequence ID" value="XM_002178878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVE0"/>
    <dbReference type="PaxDb" id="2850-Phatr34209"/>
    <dbReference type="GeneID" id="7199702"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34209"/>
    <dbReference type="eggNOG" id="ENOG502S43H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033126_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVE0"/>
    <dbReference type="OrthoDB" id="42504at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="PhoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49809" checksum="F4A82E062F8839D2" modified="2009-02-10" version="1">MVFILAIAVPVAHRKRASTQQTNTFAIFGDTTPLDDGPAVSPANISVPVASPGVASVPSSQKPSVVPTASVSEGETNTPATYVPGHLTRSENGLLLSEGLKSRILAQSGQRVPYGTGGQSSINFHGLPDFGAIYKDERPGNEGGWIYVSNSEVRLIKNKGGVGALTFDKHGNVMDYKMVLEGTTANCAGGKTPWNAWVSCEEHPSGLNWQVDPTGVREARPITLGMDGGLFETFAYDVRDRNEPHFFVTEDHFEGALRRFTPDSANWSDPWNILYGPGETEFLTLTPDSSGTAGQYGWTKNHETGKANAALHFQNAEGMDVYENELYFISKRFKSLFMLDLDTGTYTNQTTRHGLFDGGPDQLQRIVGDENELLYFTEDGGRDAGIHARNVKGQYFTILESPVYIDETSGLDFSPDATRMYVAYQKSGLLFEIRREDGLPFHGKTLNVKYHATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVN6</accession>
    <name>B7FVN6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178962.1">
        <property type="nucleotide sequence ID" value="XM_002178926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVN6"/>
    <dbReference type="STRING" id="556484.B7FVN6"/>
    <dbReference type="PaxDb" id="2850-Phatr34307"/>
    <dbReference type="GeneID" id="7199901"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34307"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779570_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVN6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="344" mass="38058" checksum="C94E39C1E40A4C95" modified="2009-02-10" version="1">METLDQLATRLKSTRTNTSGLTILITGATRINPLNRIILVGRTQAKADIARNEVITVLPKDEGHEENVIALACDHCSLNSVKPFEAELRAKLKETYRVEKWAMNGIDVLCLNAAVLVPQGSEPEFTVDNLEVTFQTNYLTPFLVGNCVLDLLNPGGRVVVATSGLHVGQTLNFDGMIDDESGSAKKEFSMIDDSEFHFKQCYTLSKVCNVAYCLELNRILQPRGIVANCFSPGLMTTSGLFRHQCYSGDSGTFVQNKHVLMKEKTVEWGAGALVFMVLADMSGRRGGEFWRDSNSTKGAKAIYGKEFCPCAISEESISQEKRTQLWRLSCELAGIPCDHNQIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW42</accession>
    <name>B7FW42_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_44920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178819.1">
        <property type="nucleotide sequence ID" value="XM_002178783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW42"/>
    <dbReference type="STRING" id="556484.B7FW42"/>
    <dbReference type="PaxDb" id="2850-Phatr44920"/>
    <dbReference type="GeneID" id="7199826"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44920"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052585_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW42"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000075">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852702" description="Prolyl 4-hydroxylase alpha subunit domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="194"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="417" mass="46328" checksum="6063506BCD438E94" modified="2009-02-10" version="1">MLVRMRLRPHFCVVFLSLLCCGVDATSSAALRRHLEFVNRSGERISVDWLNPLTGQPVLLGAPVNGETIPLDSFVNHTFAIRQHQDGQKVKRFETPSLSTTHTRTLEAPTTKSSLRAIESLQTCLEYYTALILEDKNEELAFQAQVREQISALAENHTCADPMRTTTEPIEMRSWRYLDEDPRTVQVLHNRPSSQIHVLEGFISPEECQAIKDAAAPKLHRGTVADGKGGSKLSESRKAWQAGVGVDYSHKNAISDLKKRLFAYTNEVTGFNMNLDGQEDIMSIQYFGDGVGNPTPDRYTPHCDGECNGMPHKRGGRVATMVMYCDIPEIGGGTNFQHSNVFVAPTIGAAAFFSYMNNDTGLHETGFTTHSGCPVLEGTKRIAVQWMRVGVDEDSPWDSFDTNTVQKGSFIEDSRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW87</accession>
    <name>B7FW87_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179339.1">
        <property type="nucleotide sequence ID" value="XM_002179303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW87"/>
    <dbReference type="PaxDb" id="2850-Phatr34630"/>
    <dbReference type="GeneID" id="7200057"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34630"/>
    <dbReference type="HOGENOM" id="CLU_1075458_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW87"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="212" mass="24902" checksum="3547B45321C3A17E" modified="2009-02-10" version="1">MQKKSDSIRYDEYQSFLSRSERAHEKPDKPPTADELRQRKVKFPSEPEELLTIFEFEPLNADEKHAVYMQHEDFSRVDKDMELLAFRWENHVSGRIILDEDVATIRGLEERFKNTGRGKAMAVHEKAVLEEIHSQKVEGKNSVKDLDWERIRQASLRTSKQRIDYAVQLAKEDEEARVQAWIPKQQQKLFSAATKDDKKKKKKGFLGLFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWE2</accession>
    <name>B7FWE2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179370.1">
        <property type="nucleotide sequence ID" value="XM_002179334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWE2"/>
    <dbReference type="PaxDb" id="2850-Phatr45079"/>
    <dbReference type="GeneID" id="7200166"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45079"/>
    <dbReference type="eggNOG" id="ENOG502S8Y9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760375_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWE2"/>
    <dbReference type="OMA" id="FRMFPFA"/>
    <dbReference type="OrthoDB" id="202977at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855530" description="DAGKc domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="73"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="454" mass="49721" checksum="DCFFAE6591A9EFA5" modified="2009-02-10" version="1">MPHRRLLLLCLIQCVVANGFSVQPQSPSFRPERSGLDINSNPRIGPSLVQPYTNGEASTNVSDGTTAIILNTNARSVTKDLEPLAASIFGTSHVFCTTTEVEAKQAADHIVQNLQSYKLVVPVGGDGTLASMINYLCDSIGGDVDEAMGKLPLIGYIPLGTGNGVGSVIGCRLSRGLARGTKRRKRKRLEHIMNALRRVGQGTLPKSNDFEVVEMPMMEVTHPVDGQVPTPRGDLCFFAGVGFDSLMLNDFKNIKAWSHKTGILRDFLGSVAGYCVALVVKTLPKCLVRGEHNIRVELTSNDPDCVWVDHRRGDMVRPCGEAKLYEGTTGILAAGTSPFYGGGLRLFPFARMTLDKMHLRLGRIHPVDGFVNIPSIFAGSYRDKSDRFGCLDFIGDDFEVRVQSTTAAPNSDGRGYPFQHSGESIGHVERFRLRVVKNSVRFVSFLKPRLERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWN9</accession>
    <name>B7FWN9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_45164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179413.1">
        <property type="nucleotide sequence ID" value="XM_002179377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWN9"/>
    <dbReference type="STRING" id="556484.B7FWN9"/>
    <dbReference type="PaxDb" id="2850-Phatr45164"/>
    <dbReference type="GeneID" id="7200208"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45164"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417692_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWN9"/>
    <dbReference type="OMA" id="LECNQEF"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="657" mass="71781" checksum="FD08C3BC604C8690" modified="2009-02-10" version="1">MSGSNSASKTVQRVVGSFGRLWGRGHESFPPELRRILSVSGQGATTFLQGLVTCDLQSPPAPPRPEPIDHPQPGVPKSMKMDATGTTELPEVEFTDRLRAACFLDHKGRIVTDSLLWKTDESQYFIDVPGATADSLLQHLHAFKLRRSKVTIADRTLDMSSHVIFGTLNAGGSPPGYLSGVDPRHPSLGMRVLQLPSESSSNGENTSTLNEQDSDNLSLSTRHEAFAKLVSKVFPTSPGNYELVRRLAGVAEGSELTGKIALETNQEHLQAVSFHKGCYLGQELTARVHHTGAVRKRILPLLLLDPYTEVPQAWGLASSLQQGRAGKKFSAEELRSLPTRLPRLSVLTAGNLVAITTGSIEPPGKAVDNAARDELAQIKSRAEALLARLETDCTPGAKIVDTKDGKTIGQIVAPPVKGTNVVLAIMRLESVGLLQGGVWSKTNKVRIGNGQELRYLPYLPLWWPDLDPKTGKARAEDVDGVDPDEVRDEDHSPRPVRMPKIEIEEIPLTEGERRELNFAFVLPIEHLYYERQLVFPVKTGIAHSTTVASATLVPSWIHHARLPQCLAPQRATSPRSLKHMALASLSRREKARRCRDPLGPAYGKDDAFVLVPTALPNPGNELGALNFPFSQDEAQSADFDSLALFLYMSVKGIDNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWT8</accession>
    <name>B7FWT8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_19690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179220.1">
        <property type="nucleotide sequence ID" value="XM_002179184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWT8"/>
    <dbReference type="STRING" id="556484.B7FWT8"/>
    <dbReference type="PaxDb" id="2850-Phatr19690"/>
    <dbReference type="GeneID" id="7200233"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19690"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_7_4_1"/>
    <dbReference type="InParanoid" id="B7FWT8"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855426" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="173" mass="18518" checksum="9DB12D39287EBCC1" modified="2009-02-10" version="1">MRISHKLVAATVFIGSVAAYSLNTSDRRTFLSQTAAASVSLVAAPGVAKADGQDTYSDFITTESGLKYKVTKEGTGAVPEPGQTVKAHYTGWLEGFESPKKFDSSRDRNRPFQFRVGAGQVIRGWDESFGAMAVGERRQIIIPPRLGYGDRGAGGIIPGGATLYFDVELLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX42</accession>
    <name>B7FX42_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_34936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179489.1">
        <property type="nucleotide sequence ID" value="XM_002179453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX42"/>
    <dbReference type="PaxDb" id="2850-Phatr34936"/>
    <dbReference type="GeneID" id="7200142"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34936"/>
    <dbReference type="eggNOG" id="ENOG502S3SR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325569_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX42"/>
    <dbReference type="OrthoDB" id="45851at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="886" mass="99716" checksum="FA575DFF7CC5DB33" modified="2009-02-10" version="1">MKAFRRRGAGVVAQEQSTGPTVHLTEAELRQNRVFMTIAHFMLTYPRWSLSLFLLLASSSLSLPSAKEAARQPLLDLQHMARQESDLYLECTMHAFDALGRQLEKSVQKERNRVAKTRESNQKVVLQSTTTSDQCRTASITARRALQTYRNAAFLPTTVNDSTSVCTTEDREKLTSFLGQDYTLVEKDVTNLLDAYVSASRLGAQRISLYAQDRATYDYNYFVGLKIQTTLDLLNGYQVPILSLNNLAVLDDLRALLQAIIDALKDARSQIDLLSTRLLEFQASIQGFYVNYVDIYGRLILARDFVIDFLPAGVPLPSYLDLQAIPIGDILLPQIFSLPTFGDLPEIDDLVAEYLHRAVGFIAQLLSTVAEEANEQLADGLRDLIRLLDEALTLEDYDPPKYVGSGAGVESPDEELILLQGLGDALRDSILDTLRENQEFGQDLAPLETPSLPTVEISSPNFDDNNTRTFDYLTAEFPSILIPKLIMGFAAFLVANQWIIEIVIQFIRLWKLRRKYERDASPDLPTIDYATDEDDNSDGYSQSNKLALLQAALLKHFMTPWMALGLILFPFAMVGVLLWFPHVKRNCIDTQKGTFVARNIMTPLLVNRANLAGNGYHTRAEFQCRRTQRQLCDQLYAESDSNQRLDIFTLNTALHRYNQSMDANNVFDRCVQVSALDEVFENSCCGLDGYGSNCSLIQNETLCPIDSNTLPPTAFQPVGSFLSNGACSQNPLTWTLEDARFKCEALEETCQQTTCLGVDADLIEYLAIEADCQVEVYIIKCCILILLALYHAIIINLSCTLAFNGVKHLRWRSLRPSGIQLRTHVNANGELAKGQDREDRSKRIAIAMRRFEMLGYLQLILSGAFFFMWIVTFFVFRNKLAAFDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXB7</accession>
    <name>B7FXB7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179310.1">
        <property type="nucleotide sequence ID" value="XM_002179274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXB7"/>
    <dbReference type="PaxDb" id="2850-Phatr45334"/>
    <dbReference type="GeneID" id="7199972"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45334"/>
    <dbReference type="eggNOG" id="ENOG502T20S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779571_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXB7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="303" mass="33568" checksum="5CE0645663CCBC87" modified="2009-02-10" version="1">MSLPDAQVEVSTASSADTALFGSLNATIADHLSSQVDETLAIGVATLPLLQSQPSRAETLHAMLRRCYWKNVDVFEVYCDRNVFTTNMFPIERRTAIAELYTQAQRENTSADTILQEAFAQTVEEATTSPTDAPRKVESAVPVPSEQDVQDLHKELASLRLRLRDAHRRKLQVTQSIKELDVANHLANLANETLQVCPNPDGSPALGLDQVHQTVTATLVGTERLTTLQGKGLDVIQEMERKTRERGPEEEPEDTVDLMLASGTINRHHKKPKTLTERYAQEQAEMGTHRTAVRAILGDSNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXI3</accession>
    <name>B7FXI3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_11901</name>
        <name evidence="1" type="ORF">PHATRDRAFT_31375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179770.1">
        <property type="nucleotide sequence ID" value="XM_002179734.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185588.1">
        <property type="nucleotide sequence ID" value="XM_002185552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXI3"/>
    <dbReference type="FunCoup" id="B7FXI3">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXI3"/>
    <dbReference type="PaxDb" id="2850-Phatr11901"/>
    <dbReference type="GeneID" id="7199436"/>
    <dbReference type="GeneID" id="7200520"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_11901"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31375"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXI3"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="168" mass="18693" checksum="E2B7AB1BE5A6C27E" modified="2009-02-10" version="1" fragment="single">MGNKISLEEELVNLRITSKQMHRSSKKCEKNEKAALEKLKKAIQQGNSEGARIYGQDAIREKNQSLNHLRMASRLDACCSRIETAVRMNAVSDSMKGVVKGMGRSMASMDIEKLSSTMDKFEQQFEDLDVKTQYMEGAMNATTATSTPAEQVDELIGRVADENNLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXL2</accession>
    <name>B7FXL2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_3015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179575.1">
        <property type="nucleotide sequence ID" value="XM_002179539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXL2"/>
    <dbReference type="FunCoup" id="B7FXL2">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FXL2"/>
    <dbReference type="PaxDb" id="2850-Phatr3015"/>
    <dbReference type="GeneID" id="7200503"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3015"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_0_1"/>
    <dbReference type="InParanoid" id="B7FXL2"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="233" mass="25547" checksum="0E94C1975CA834E2" modified="2009-02-10" version="1" fragment="single">YVLAPMVDQSDLPFRLLCRSYGTNLCFTPMIHARLFTTNVEYRRKFTLQYGPPQDRPLIAQICGGDVQAVVACALAMQPYCDGIDINCGCPQNIAKRGNYGAFLLEQEDVLLPLVHTLLQHLSVPLSVKVRLLPAETRQASLEASLRLYTKLVDAGVHLLTIHGRTRHHKGPLTGAADWDAIRVVVDRLGQRIPIFANGGVASLRDAQACLATTHADGVMSSEALLEYPALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXP0</accession>
    <name>B7FXP0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179801.1">
        <property type="nucleotide sequence ID" value="XM_002179765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXP0"/>
    <dbReference type="STRING" id="556484.B7FXP0"/>
    <dbReference type="PaxDb" id="2850-Phatr45435"/>
    <dbReference type="GeneID" id="7200546"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45435"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357715_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXP0"/>
    <dbReference type="OrthoDB" id="42345at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="784" mass="88868" checksum="FFDACA7B560BA0FA" modified="2009-02-10" version="1">MYNHSISSETIRRYFCRTVAPLIVISSFALFHTTQSAFVPTRSFRQDHAPSRRQSFLSGSVPILRSIAVDDDTAEESSLPRQQTPSDQKPSVNQLVTDRFHEDMLRVLESRSHFLADSLKQSMQRHTRPVILDHNSDPDGAERVLSMLRHLQNINAATEESFQIVMQAFVNRGRVRWQEHNKNVMCAADQVETLLEELLRSHPRSTLSMETFQLALQAYATCSTPRGDRDYANRADELLQRMESMFGQVSVEALVHVLHAYAWQQANLQEGDCASRATDLLNQIVKRTNDPVILMKCYNWVLEAWSKNGSPGSADQADAVFKKAQSLAQSLPVSKEKAAKMLDAESYSNAILAWSKAHDIGSAEKSHELLLEMIEKFETGAFPEESEPPLIAFNGVISAWGRVGKPDRAHDILRLMDKLQTKCETLVPDSLSYNTVLHAYLRLRNRKSSLEKSLALLKHMEEHSVKQPAIKPNAFTYNTLVKCWVQSGHMDSGEESEKLLLKMERLWANGDRSLPPNNRVFNMVINAHAKKVNDRSAARKAEKILLRMRASPSCQPDIITITSILECWSKSGDPDAPLRAETLLQEAFDEYYKTRERAMMPNLRTFTMAILCFAQNQGSTVKARALLTQLVDLYEETQDPELKPNEYPFNYVLNCAANSLENQTQAFQIATQTYQQMRQSPTVRPDSFTYNFWLKCCNNLLPPSELRAKCVSYAFDECKKDGLLTKEVLTRLFQGNPPALVDELLELTATPATAATHPSHVRPSYRTLSVQDLNPSWSRNASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXY1</accession>
    <name>B7FXY1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179639.1">
        <property type="nucleotide sequence ID" value="XM_002179603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXY1"/>
    <dbReference type="PaxDb" id="2850-Phatr45514"/>
    <dbReference type="GeneID" id="7200719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45514"/>
    <dbReference type="eggNOG" id="ENOG502SU0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835466_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXY1"/>
    <dbReference type="OMA" id="EVWWSIR"/>
    <dbReference type="OrthoDB" id="44504at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855580" evidence="1">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="272" mass="29305" checksum="DDC43EA3E11EFFBE" modified="2009-02-10" version="1">MLFLHTLAVVYLLSLAAPVRSLVSPRPIGSFRSISTTTGTATTTQLYSSIAIRIEDESAHKYMMARAKECAFSEATTASEAQRYLHEILHIQSGCVSGVLASHDLCDNIMETAEIVAHLREKVRDNAGMSVSAVASSLVPLSLVILAASVYAFALHAGTNTQPFTLQEWAWAARDGYLPTMIAHFITDGGLASADLHPHDVVPLTPQEWMWALQGGYLNSMLAEVYHYGGLAVDSADTIDAGSPFVAEEWAMAVKGGYLPTMLSHMYTNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYM2</accession>
    <name>B7FYM2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 13">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_35566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179996.1">
        <property type="nucleotide sequence ID" value="XM_002179960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYM2"/>
    <dbReference type="FunCoup" id="B7FYM2">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FYM2"/>
    <dbReference type="PaxDb" id="2850-Phatr35566"/>
    <dbReference type="GeneID" id="7200916"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35566"/>
    <dbReference type="eggNOG" id="KOG3367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_3_0_1"/>
    <dbReference type="InParanoid" id="B7FYM2"/>
    <dbReference type="OMA" id="MQWRVAP"/>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="50"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="222" mass="25214" checksum="27EA55E63E41BD9A" modified="2009-02-10" version="1">MRTEESENDRLAPVFVHDEPKYFEKEAHLYPPEYEGHFESLVMTAETIRSRVRDLAAIIKEDYAGMRPVLLCTLKGACPFYTHLTDALQDLCQGYDMEFVRASSYEGTSSSGNVIVSGVKPESLQHRHVLIIEDILDTGTTLAHLVPHLEDVGKPASLEVCTLLDKRLEEPKKYVAKYVGFSIPNHFIIGYGLDYNELYRDLKDIFIISKEGISFDRSNLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYP4</accession>
    <name>B7FYP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DETOXIFICATION</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_35587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180009.1">
        <property type="nucleotide sequence ID" value="XM_002179973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYP4"/>
    <dbReference type="PaxDb" id="2850-Phatr35587"/>
    <dbReference type="GeneID" id="7200805"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35587"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030929_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYP4"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF46">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855181" description="Protein DETOXIFICATION" evidence="7">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="59876" checksum="1198B15E1C489AFF" modified="2009-02-10" version="1">MRFLFVCVLSGLCGTTNAFVPSVRSAASLHGRDSLQTQAEKVSRRWSNLNDVEDDLFDPLRDRLSNMNATIVAPEATETDVVDNTLLNLVVDSDREPHPLGWKRRLTQALSGRKAGRQLDKLILSTSIPSMINLAVVPLVNSVDTFWVGRMGSALALAGQAAANQAFFTIFFLVNYLPTITAPLVASAVGSGNQDEARARVCESLFLCNVLGLMGTLSLTLFPQWGLSMVLQDGAPAMEYAVPYLRLRALSMMPALWSSSGFAAYRGLLNTVTPLKVSLATNLVNLVLDPLFIFRTPLGFVGAALATAISETCSGIVYLRLLMKRQLASIKLLLRPPSMKALMPLLQGGASMLGRQLALNVGFISAARRAQSMDPSGVSAAAYGIVMQMYSVGIVVHVAMQGTAAALVPSTLAREGKDAARKVADRVMIWGSIVGVLLGLTQYLALPFLVPLFSTLPEVQEAVKVPALLAALLHVINGAVFAGEGTMLGLGSYRDLMLLTAGSVGALVGCLSSPLGARLDGILLSMMVFCGTQGIAVVTHYLKFGPLAVRRQSKRTLMPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ30</accession>
    <name>B7FZ30_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-coa hydratase</fullName>
            <ecNumber evidence="4">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_54494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180274.1">
        <property type="nucleotide sequence ID" value="XM_002180238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ30"/>
    <dbReference type="STRING" id="556484.B7FZ30"/>
    <dbReference type="PaxDb" id="2850-Phatr54494"/>
    <dbReference type="GeneID" id="7200989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54494"/>
    <dbReference type="eggNOG" id="KOG1679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="InParanoid" id="B7FZ30"/>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF173">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDRATASE-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="305" mass="33323" checksum="FA8CCFFF33353497" modified="2009-02-10" version="1">MWVLRTPSRCLFRIPVSERSELRRLQKANFSAAESLIGWEVDDETKIGTITLQAQATYNALTVEMGQEFGALCHQIRLDVTTGGQEVHAIVLQGQGDKAFSAGGNFEWLRSLRNNSVHHNADLMLQFYHSFLCVRSIPVPIIAALQGPAIGAGAGLALACDLRTAAPKRKILGFNFTKLGIHAGMGGSHLLEAALGGPSAIMNEILLTGKVLSGEECLERGLVNRLANDAKESAYALANDIAKQHPLAVRTNLQTLRQSQDNGLEQALQREALAQAICYNREDWGEGIDAVAEKRDPIFEIYHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ53</accession>
    <name>B7FZ53_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180289.1">
        <property type="nucleotide sequence ID" value="XM_002180253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ53"/>
    <dbReference type="PaxDb" id="2850-Phatr35746"/>
    <dbReference type="GeneID" id="7201131"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35746"/>
    <dbReference type="HOGENOM" id="CLU_985048_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ53"/>
    <dbReference type="OrthoDB" id="46767at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="241" mass="25898" checksum="AA054C8EF6D41B7B" modified="2009-02-10" version="1">MTVSALSMLLVSPDLYQRSALPFPAVQPFVSANIMTTPSSGAASSNSCCSSTSLGVTAGPAFDTAALAFFGGLRIPASLLAGSSLASLFAMVQQAKATKTLSRTERVALWVYHSSALGTLCLSLLTVITTTVGSTLLLLGRFDVSQYGDVYHFLRGNFLMEFVVSRWSFLCSVQLFLLAIMNRVLLEFDLLKPGRRTIGLLVAAAMMGLIAHCLSYINTTLNCWPNLLYMTKQVVEVSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZ97</accession>
    <name>B7FZ97_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180310.1">
        <property type="nucleotide sequence ID" value="XM_002180274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZ97"/>
    <dbReference type="PaxDb" id="2850-Phatr45952"/>
    <dbReference type="GeneID" id="7201025"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45952"/>
    <dbReference type="HOGENOM" id="CLU_2282927_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZ97"/>
    <dbReference type="OrthoDB" id="194874at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855210" evidence="2">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="10833" checksum="9754A10B5BC90B83" modified="2009-02-10" version="1">MRSLRLWMLLVMVATLDLSLAFTTKKREPSRHVFVAPGKEEAAATVSHQQQSNAAALAFAQAVAYGMPLTDDADDEIEIGYGTALISCALSLALGFGLGYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZR1</accession>
    <name>B7FZR1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_27326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179990.1">
        <property type="nucleotide sequence ID" value="XM_002179954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZR1"/>
    <dbReference type="PaxDb" id="2850-Phatr27326"/>
    <dbReference type="GeneID" id="7200908"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27326"/>
    <dbReference type="eggNOG" id="KOG0763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="InParanoid" id="B7FZR1"/>
    <dbReference type="OMA" id="YFFCYEG"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="99"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC48181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30073" checksum="4F896FEABCE9682C" modified="2009-02-10" version="1" fragment="single">MVSKPSRVSLTEEAAGGLLAGIVGTVIGFPLDLIKTRMQTHQGQPGGGIFENGLRVVKSEGILALYKGIAPPLISLSILNTFTFASYSYFQTIFQADRGWDWRNSVAGGVCGPFAATVSTVENLVKTQMQVDNISKKQFIGSWDCVTKLTRTHGPLILYTGFGINSIREIAFLTTYFGLYEGLRQTFGDLAGRHPISTWTIPVAGGFAGAASWFLSFPLDCIRAGVQGQDMSSQRKGSLKVLWYLMETKGVKGVYGGVSPSIVRAFLVSGSRFSAYEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZS6</accession>
    <name>B7FZS6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_2097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180550.1">
        <property type="nucleotide sequence ID" value="XM_002180514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZS6"/>
    <dbReference type="STRING" id="556484.B7FZS6"/>
    <dbReference type="PaxDb" id="2850-Phatr2097"/>
    <dbReference type="GeneID" id="7201394"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2097"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="InParanoid" id="B7FZS6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00270">
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    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00490">
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    </dbReference>
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    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <begin position="153"/>
            <end position="338"/>
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        <location>
            <begin position="349"/>
            <end position="509"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="64"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="552" mass="60289" checksum="8D136C119DCC12C7" modified="2009-02-10" version="1" fragment="single">NKYVPPHLRNSQGSGGRTSDSVSDGRGGDRRDSYSDRRGDSGGRGGYGGDRRGSYGDRRGEQGRRGQSRRNARGFHGDLKEDPRTQARLFGRDDHQTTGINFDNYDKIPIEVSGDDVPDPIETYSPETIGDDLFRNTQLCGYSRPTPVQKYSVPICTQGRDLMACAQTGSGKTAGFLFPIIMSMIKRGGSDPPENARRRIYPEALVLAPTRELAQQIHEEAKRFTYATGIASVVIYGGANVGDQLREMERGCDLLVATPGRLVDLIERGRLGMESVSFLVLDEADRMLDMGFEPQIRRIVEESGMPGGIDRQTMMFSATFPANIQRLASDFMRDYVFLTVGRVGSASKDVTQTVEFVEERDKVDALMKFLLTIQDGLILIFVETKRSCDYVEDVLCGQGFPACSIHGDKSQREREDALRYFKNGNTPILCATSVAARGLDIPNVTQVVNYDLPSNIDDYVHRIGRTGRAGNTGAALSFINESNSGVVRELRDLLDENEQDVPPWLNQMCQFSGGRSSGGGGRGGGGRRGGGGGGFGSRDVRSKGGNDRGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZV7</accession>
    <name>B7FZV7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180566.1">
        <property type="nucleotide sequence ID" value="XM_002180530.1"/>
    </dbReference>
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    <dbReference type="STRING" id="556484.B7FZV7"/>
    <dbReference type="PaxDb" id="2850-Phatr46048"/>
    <dbReference type="GeneID" id="7201411"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46048"/>
    <dbReference type="eggNOG" id="ENOG502S25I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455973_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZV7"/>
    <dbReference type="OrthoDB" id="536576at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36970:SF1">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36970">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEC47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="599" mass="66715" checksum="2C1B15B65D58FCA7" modified="2009-02-10" version="1">MEKDSSFQPGSDTNKSTPDESNKTSERSDDARRRSSFLGFDVAGSLPFRSTTKATNVGAHPKASHQHPIFDVPFPANNFDFRQKADNKVVGLKDVHQYRSMMEKRREWATSAHSHKSATSHVIPQGPSVEELEGKARSKAESNPIKLLYLGNMAALKVFGYYLITLETILTCAVTVGLTIYWYRAYDETEWNGGGMDFILLAFAITSPISAAIGMAFTRRERALVALADFRSFSYHLFLAHCLWDWPDNGGRQGAIDVDWVEHCDAVLAQLIGMGDELARFLSLPTANRSRHKLTKQGRKEASRTMEVSYQLLESITTQRMTRLILYSERLKKIGLPSGEVSRIRQYERFMSNMVEQLRMVKMYRTPQALRSFARVFTLLLPPFYAPTYAQVAMDVNSLGVGIAFSIITAVGLTALFESLQVLEDPFTGFLALDGIDVREEFEVLHYAQLISTRKLVFPDAPPFPAGRRGAITGRHRLTVPKMIGKPPIQTHHERHHSRLPSNMDMNAVENAGHGTAATTSGDNSVGTIGPSPVEFDLGLLNLDYVDEELGTPLVNDDEATVRESAFTDHDDDSLIGRQRALSSSGRLASRRAAFAPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G005</accession>
    <name>B7G005_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180595.1">
        <property type="nucleotide sequence ID" value="XM_002180559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G005"/>
    <dbReference type="STRING" id="556484.B7G005"/>
    <dbReference type="PaxDb" id="2850-Phatr35966"/>
    <dbReference type="GeneID" id="7201328"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35966"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559582_0_0_1"/>
    <dbReference type="InParanoid" id="B7G005"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53644" checksum="1BD86D31794A9833" modified="2009-02-10" version="1">MRLITGDECGLIKETIPELARAKQRSATKPVQVQNSPRAVAVVKNVGTAVVNVGLTIPTRTKGVVDLTWLETDQDKSFASLCIDGSVQVWQRSVSEEQTYGRYRQVAAHANIFASQQTQTTHRSIHPSTSPIGMSAFPASNANLLCAADAQGNVTIVNHTAETPIVRQFSPLATSAPSNGSKDPLITAMAVDAKRARVAMGGRERETVLYDLETTQAVWKAKNLPPDPQTLLQALVWPTSILFLNAYDSSSLGQNVLAVGTAHRQVRIYDIRDDSVQRRPFSVTPAKGFVEHRVTALCQMDPYSIVVGDSSGDLHTIDVRKLEHKYNASTQLSDGRYPGPAGSIRSLAKHESLPFMAVVGLDRMLRIYDTNSRKQVNCMYLKQRVNCVLMGRDGTWGVDGEDYNNSDVEQDDIVRDYVDSDHENGDDQSFAEEESIDQANHTDDSENDAKDDSASGSSDSGDHQDDDSDDNKSQNEEPTINPRKRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G034</accession>
    <name>B7G034_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_46109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180609.1">
        <property type="nucleotide sequence ID" value="XM_002180573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G034"/>
    <dbReference type="PaxDb" id="2850-Phatr46109"/>
    <dbReference type="GeneID" id="7201445"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46109"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352524_0_0_1"/>
    <dbReference type="InParanoid" id="B7G034"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="7">
        <location>
            <begin position="376"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="770" mass="86265" checksum="42E4D09B2F9BF80D" modified="2009-02-10" version="1">MQSLNLTVKVIRHVSHEAPPAPAVMKVREEPAVPKPKHDHAPNPLHASRHENHQPKSDKLKAPVERVDETADEKHDSDTETGDDPVVKPHEILPLVVEEEREDREKESPMQPVDSAVLDPESTQVLQKHGTGATLLGYVVDMVQERAHPSFRKLPVSIRPDTAKVASLVGEASVQACESVVAQSNDNPEARPSISQNPHCRDEDTVLVVYNSATFSRRYCGKTIKPGQALKLDQDMDDHCRLELPRVFAVDDPPLDGQGMAPIIVQSKATAQQETALEDSELETVPCSIPCQWEKDISGKDLVIAGTTWQLHQTMDDPYFHDDAKIERTDFRSDKYYSTTSLRSSIPLTFYDSSKHSLRNRPALDWANTANAATYVLNSNCQTQGTRRQKWLAAVQAVFRVAAYGSCQHNTDLAPGETVDTLEGRLALSRKNRIHLAFEAASEKDHLTDVSFEALLSGAVPVLLGPSNANQLFPPHSAIFASDFNKWDALAAYVKEVAENRTLWESFHIWRTDETVLRTWESRWAFAETTASTASPQCRTCRWAYAKEFGLGWNHTAQTIQPTHLPRDLCLDPTSKIVMKPFREYWVQRGSQLEDIEVDTGDGCSKPMSSSTIEMDGYKVEREVSEHDGVVDIVVQSVEKESVNEPVTLRLHVDVRNSEGAYFRNPHTLVSTSRGPWISSAAIQDEFSKVTVLTSWETSVHSPQEGILEVSILKENESFPTNNDGVRRIRVILEDVNMLHDKMTEHFPSSYAKVMIQDFVDPLELFYVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G080</accession>
    <name>B7G080_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180430.1">
        <property type="nucleotide sequence ID" value="XM_002180394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G080"/>
    <dbReference type="STRING" id="556484.B7G080"/>
    <dbReference type="PaxDb" id="2850-Phatr46148"/>
    <dbReference type="GeneID" id="7201365"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46148"/>
    <dbReference type="eggNOG" id="ENOG502RYDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G080"/>
    <dbReference type="OrthoDB" id="71417at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57817" checksum="2157B586D8FFEB9E" modified="2009-02-10" version="1">MLVLAFFRFDELPNFTCSHGASFRERNKSQPDCFVARRSAPMCSPRNGFFGCSTGQYPHRETALTPSAPKRQLFKQVVVNEMSQKRHRKDHTYDYGLPRDYATVFPTLGAELDAFFTFMTKPSILSSEPPLRVVTANVYLRHAKLFLGWYVNIYQCQGELDPSMEPKFGTTDPSLYNIIPNQEKNSATCFIDFLLWLRSNRQISVSYEANVLRGITKMLKFRFARDCSPDRTGDPSKPFDDVPILRELRKLHRQANGQQRLAPRVSDETKKWLSWPEYLGVVQQSLTEVDQLLRAYNGPDPETVEASFTVEQRRISVAYQKYLILAIFASIPDRQRTIRELELDRSFVKDIASDSWGIKHAPDDYKTGKTYGERPLLQLSPSLTPAIEGFVSHWRLCLRPQTKHVFVQPRTCNPLTQDSVYQIVSRACFQYTGKRTNPHLLRDMIVTHVRESDASEKQLEALALFMGHSIQVQRASYDRRTLNDKVAPAVELIRSLNSVSLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0H9</accession>
    <name>B7G0H9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 12">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OAT</name>
        <name evidence="13" type="ORF">PHATRDRAFT_27726</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:25160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 12"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180480.1">
        <property type="nucleotide sequence ID" value="XM_002180444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0H9"/>
    <dbReference type="FunCoup" id="B7G0H9">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G0H9"/>
    <dbReference type="PaxDb" id="2850-Phatr27726"/>
    <dbReference type="GeneID" id="7201290"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_27726"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="B7G0H9"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="48685" checksum="7BDBFB418F97C71E" modified="2009-02-10" version="1">MIRSLAVTNNPLALIARRSLATVVAASKHVHEGPSAAAKHCIDLEEQYGAHNYHPLPVVLTKAKNTRVYDVDGREYYDFLSAYSAVNQGHCHPKLIQALTEQANKLTLTSRAFHNDSLGEYSKFVTEYFGYDRVLPMNTGVEGGETAIKLARRWGYAVKGIPPNQARVLFANHNFWGRTLAAVSSSSDPTAFRGFGPYMPGFSHVPFNDLGSLEMEFEKDAENIAAFMVEPIQGEAGVVVPDDGYMKKAKELCEKYNVLLIADEVQTGLGRTGYELAVHHDQCKPDMVVLGKALSGGVLPVSAVLATDEVMLQLKPGEHGSTYGGNPLACKVATAALEILRDEKLSENAQARGEQLRNGLQKLVDDNSSVVKVRGRGLLNAIVIDQPKMGYGAAGKAMELCTIMMENGLLAKPTHGNIIRFAPPLTITEQETDECLDIIASSVKELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0L6</accession>
    <name>B7G0L6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOD1</name>
        <name evidence="10" type="ORF">PHATRDRAFT_12583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180497.1">
        <property type="nucleotide sequence ID" value="XM_002180461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0L6"/>
    <dbReference type="SMR" id="B7G0L6"/>
    <dbReference type="FunCoup" id="B7G0L6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G0L6"/>
    <dbReference type="PaxDb" id="2850-Phatr12583"/>
    <dbReference type="GeneID" id="7201207"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12583"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_1"/>
    <dbReference type="InParanoid" id="B7G0L6"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="24238" checksum="321A4F9C8D0F04EF" modified="2009-02-10" version="1" fragment="single">AYSVPDLAYPFEALEPYIDTPTMKIHHDKHHGTYVANINKATEGKDEVPILDLMENAIEAGPAYRNSGGGHYNHAFFWDEMAPPDQAKNTKPSAQLVDLINASFGSMDEMKSKFEALAAPGATFGSGWVWVCVNQKGDELKLVNTPNQDNPLMKGVADEIMFPILGLDVWEHAYYLKYQNRRPEYVSNFWNVVNWDKVSENCAYVVEKHVGVSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1K4</accession>
    <name>B7G1K4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180875.1">
        <property type="nucleotide sequence ID" value="XM_002180839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1K4"/>
    <dbReference type="PaxDb" id="2850-Phatr46540"/>
    <dbReference type="GeneID" id="7201685"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46540"/>
    <dbReference type="eggNOG" id="ENOG502SK9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592473_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1K4"/>
    <dbReference type="OMA" id="LMRWTCM"/>
    <dbReference type="OrthoDB" id="42679at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="462" mass="52425" checksum="8279611FDCFCBD37" modified="2009-02-10" version="1">MASPMQFGKPSERSGTMEHCQTMIMDRNLSQHRNRGINSGTVTPSMGGISRNASYSSDTAPLLQRSGSSIPSILEYESTNNRSSQNPTERPTITEATNTIRFQVIVWYVGKIDMVEGRVPITFRVTIYWNALDEVDEEEQVHDDETSASTLSRRPAWQMHGRQKAFVKELKDVPSQTVEVPPVSILNVVTFDTIGSPEVSLLQEDTRLMRWTCMYRATLIQEHWRVDDFPHDEHEISLRMAVLAHRQPGSQWDRRIWKLSLATADDSQGSVRVPYGLVVDQVSIPEFSYNKNDGLSFAFEPLDHGPGGNIDRDTCLEVKLKVLRDSSYYDRNIMPLLGLLNFVAISITALEAQNFFERALLTLNITFVEIGMRMTADSKLPSASYQIKMQRILNEYFYGLLVLVLESLFVYELHNYGFRGTGVVDAIAALAVFSHNAYTLFTYYSDAATAQKKFFQIKQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2F2</accession>
    <name>B7G2F2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181198.1">
        <property type="nucleotide sequence ID" value="XM_002181162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2F2"/>
    <dbReference type="FunCoup" id="B7G2F2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G2F2"/>
    <dbReference type="PaxDb" id="2850-Phatr47094"/>
    <dbReference type="GeneID" id="7202010"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47094"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005260_2_1_1"/>
    <dbReference type="InParanoid" id="B7G2F2"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="503" mass="56095" checksum="F5584F63AEF04EBE" modified="2009-02-10" version="1">MNSSSVCHEIPDCPRLFVDAFRGAYLQKTRNPDNVFILSHWHGDHYGSLPRDGKYQGPSLIHCTPTTAALLREIHQVPEKYVVEHGYGETWLFHPLGNTKGLSTVQITFYDANHCPGAAIIVVEMADGKVHLHTGDMRYHTMMNVYPILERAASSRAIDTVLLDTTYSDPKHNFQPQEAAIDAIAAYSEGLLGTSRKCCSNVLILLSCYSIGKEKVLWEVSSRTNQLVYVNDRKMRMMRCIQKHHESSSQIVQRCTTDPNATDIHVIPMGLAGELWPYFQPNYWACAEYAKALETEYTKVVAFIPTGWADGSKWNKKNATSKFDCKGIEVEIRLISYSEHSSFSELKTFVEFLRPRKVVPTVFKDDRDRVKIEGRFAIDSGRAKQSFFSTMTSKSSNIGKQVLPGAATRLDPFPKRPKLNMSRSSPLKQKEGHVEKLASMRLMGFSADAANGALVESKGNIEEAVGLLITGKTKLPPTAEVIDLSGTNDVVESKSVPATPCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2J5</accession>
    <name>B7G2J5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181390.1">
        <property type="nucleotide sequence ID" value="XM_002181354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2J5"/>
    <dbReference type="STRING" id="556484.B7G2J5"/>
    <dbReference type="PaxDb" id="2850-Phatr47119"/>
    <dbReference type="GeneID" id="7202032"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47119"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032951_2_0_1"/>
    <dbReference type="InParanoid" id="B7G2J5"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="459" mass="50123" checksum="0F72E1CBC2A7290F" modified="2009-02-10" version="1">MSSHPNNPSILSLWQLRQSGHCTARAFSNEIIRKRSMKALISTPSIRAPDKCVTSLDVHKLDCRYLLSGSMEGIVSVYDLSRWGASPLGKTGSEQQELVHQPIARSFIATATGQQSCEVPRGHSLAILSALWYPLDSGMFLSASTDGHVLLWDTNEMTPVTRLAPFEFENTSMGEEVFARPSCMEISLWSGNLAALGSRRVNAVKLVDIRTGTSSHSLTGHRAGISTVQWCPTAEHVLASGGQDGCIRIWDIRKAGSTGCLTTLDRDACQEPSVSNRFKADYSHLKITKQKLAPNDYHLAESKSIWSVEGSVTGLAFTPDGHSIVSTSSDGQMQLWDLRGPASMAPQRFTNSVGGRPLAKSKSTTHRRPLLITKNGNSSTVWVPNGRVLLGFSLEDDGSPTQILSGHLQGIQAIAEVPDTGEIITSSTDRLILTWGYPQPLHTFASSRKRRLEDDRDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2S1</accession>
    <name>B7G2S1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_47181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181431.1">
        <property type="nucleotide sequence ID" value="XM_002181395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2S1"/>
    <dbReference type="PaxDb" id="2850-Phatr47181"/>
    <dbReference type="GeneID" id="7201958"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47181"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529442_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2S1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="515" mass="57200" checksum="44E9EB7991A0A3CA" modified="2009-02-10" version="1">MNDLENVDINRGSHLPTQNQEGGTEPPSGFILKLFQMVNGAPDKVISWTPNGDAFIIGSDLNRLESETLPQYFRHNRFQSLVRQLNFYSFRKINRERNVWIYKHSLFHRDRPEDLNMVRRRTCPGMDGRKQRFSRFSVGSLGQADGDDNSDNEDSSLEATVDAYSSPVIPSKKRDLISADKTLKPPSSKRFRQSSNADKETKTESKVVVDTSMLEEVINETQPLVGDKGSFSLLTNRAPVNVNINVADVASKLEKCARKAMKERGLARSLRSGVVTPPYGASNGFQNSSTALLTYDDEYETNGGILFEVDARTSPATIGTIPVDGDESVFSDYERSSRFRKPHTVTPLKRGPKGRPPVSDASAVESILNRIMKNQTGQTPSPFITPVAVAGFCMSTSPLGDRQLCSKILQLIASCSALASDFQLYRAALHPTNPKEVPSYMFSPSPRESRAITVQQIWQREVSRGDAVRDFKTFAVNCMHQLLGKGNVEALWSREETDMLEHAAGVWLKSAGVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3I5</accession>
    <name>B7G3I5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181622.1">
        <property type="nucleotide sequence ID" value="XM_002181586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3I5"/>
    <dbReference type="PaxDb" id="2850-Phatr47484"/>
    <dbReference type="GeneID" id="7202269"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47484"/>
    <dbReference type="HOGENOM" id="CLU_1009940_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3I5"/>
    <dbReference type="OrthoDB" id="39241at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855683" evidence="3">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="276" mass="30273" checksum="34E190145F57B536" modified="2009-02-10" version="1">MPAKRTRSVLGLSVVLLALPIMTASFSTMPSKYSPGRGHVGDLRSSPIRVTGRPSSIRTDRRLRHAPSQAPASGSTWRLGMSSPVHDDSPAPSHRRDESRDDHDPTPAAGWIRWLDAVRRETSRARKLPPLQVEDLNLLFYDVFLILNLVVSISFWVVHRMQLEFIGLAFNEGCLVCLLWIAAGLYSGAFLDSAVDGHYGSADERGGPKAAGLLGFQTFVNTINLRLLFALVVALAEHRPVGAVGGEQLMPLEIGFGLILMSGWRALHSSFVPRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4P3</accession>
    <name>B7G4P3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182110.1">
        <property type="nucleotide sequence ID" value="XM_002182074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4P3"/>
    <dbReference type="PaxDb" id="2850-Phatr47727"/>
    <dbReference type="GeneID" id="7202719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47727"/>
    <dbReference type="eggNOG" id="ENOG502SSW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385660_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4P3"/>
    <dbReference type="OrthoDB" id="48355at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="794" mass="90533" checksum="B683A4E96DDF0160" modified="2009-02-10" version="1">MTDPASHFLSPDVDYLTIMVAPQFANQRTFAASWRRSSKRRDTTKLSVLRILGLTAVSFVATKIPVSFFSFESERGLVELTVDPQLVTELASSIASYESPPVPRETPWTVFYNVYLPRTNLTHALTIVEEQLEQVSSSYGATKPGYAPTPVHFNTIGDPIGAKKVQLYCATKTNLHCVHMQHYDDGNFEDVTLTRLFEFCSNNGMDLPKFHPDDERRDPTVVYLHSKGTYHSSEMNDHWRRFMTNAAMGEGCLNFKGRHNARTNGDSQINLDSTDITQCNACGFMFYPIWTPFFPGNIWSAKCSYIRKLMHPQVFKNQSDSTANKAVALMREGRFTMNLLSPYFEEGGYLGRERFADEHWVGSHPSLVPCDVAPRPHLMKWIHPKYLNRSRTQLFDTQPLEWSLAPRHPINEDWLFFQGIQKKYKLVADRNWRHREFFLLPGALWKWITWYNAVPPASSYVWSWFPEGLEWLGRVQTLGTQEKLGEPNFPRVVHQRLQSIGARSPGATVFFNTVGEMGVRDVAEILFFCRETYQLNCVHMEHLDAGMELVTWGRVHDFCQIHNSSRVGFVHAIGSTADPNQARREQLHLFETEAVASDQCWTKHLGCDTCSLTSTVNTEFENAPKTFNAGDIRGNSSSQRTKNDFDSQQKKLMLTAIPSTWTASCAYILNIGSPSDFAARFSQKHWEVRGTYGGRWIMKYHRVGNCDVNVLFVAAPVQKLGRGTFQHGHYRHVTIRISCSGMVKLYFVAERKPSYLKESQGGIIAFPHNDLRAQKMKKVIHGASESRLADKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5J7</accession>
    <name>B7G5J7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182428.1">
        <property type="nucleotide sequence ID" value="XM_002182392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5J7"/>
    <dbReference type="PaxDb" id="2850-Phatr47974"/>
    <dbReference type="GeneID" id="7203223"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47974"/>
    <dbReference type="eggNOG" id="ENOG502SKKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G5J7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="97006" checksum="A18160606A27CCE2" modified="2009-02-10" version="1">MSTSAQFKLSDFPHKVLEPIATLTAPPTYATLKVAQRQLSTNAAAIPTLNGGGAHGHMALTLTARAYADISDVPFDIPVAPPANPPVGTTQPQITEFNRIHQRDADIYNLYVAVNNALRQQLLDAIPKIYVRALGHPIFEFSTVTCLDLLSHLWTKYGTIKPADLQNNLQSMYTPWNTAEPLETVFLQLDNAIAFSIDGNDPISEAAAVRAGYDVLAHSGLFPQDCKEWRKLPLVSHTLANFQAHFTLADKDRRLTATTGSLGYANVLTATPSLAPTISLDPLSLPFSALSILNSSVVPSPPSPHTSAIADTGCTGHYITVDCPHQNKQPANPSLSVCVPNGSVLRSSHVATLALPGFSPTACQAHIFPGLASHPLLSIGQLCDDSCTATFSATRLDIHRDQTLLLSGTRSRHTGLWHLDLAPSPPPATAHALIPHSSLTDRIAFIHASLFSPALSTWCNAIDSGHLTTFPDITARQVCKYPPASPAMIKGHLDQQRANLRSTKSPPIGPLAAPIAPTATSAHDRPPVARTHHVFATHQRVTGQIYTDQPGRFLTPSSAGHTNMLVLYDYDSNAIHVELMKSKSGPEILAAYKRAHTLFTERGLRPQLQRLDNEASAALQTFMTSEHIDFQLAPPHLHRRNAAERAIRTFKNHFIAGLCSTNPDFPLHLWDRLIPHALLTLNLLRSSRLNPKLSAHAQLHGAFDYNRTPLAPPGTRVLVHVKPAVRETWAPHAVEGWYLGPALHHYRCHRVWITETRAERVANTLSWLPSQIPMPTASSNDRALAAARDLVHALQNPSPASPFAPLDAHQHQALTHLADLFATIAAPASAAQTPAPVPTVRPPDLPATPPQVRFAVPLVTAAHAPALPRVPTPSPALPRVTPAADAAQHANSHQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V4</accession>
    <name>B7G5V4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_38433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182471.1">
        <property type="nucleotide sequence ID" value="XM_002182435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V4"/>
    <dbReference type="PaxDb" id="2850-Phatr38433"/>
    <dbReference type="GeneID" id="7203419"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38433"/>
    <dbReference type="eggNOG" id="ENOG502S769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512406_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V4"/>
    <dbReference type="OMA" id="ANAWAQM"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="532" mass="57218" checksum="7146F95985EF2721" modified="2009-02-10" version="1">MSYKKTASADRDALFGGVPAATEGGRDKKKTTNRTARLSSSTTETARPKPTAVPTNQGYRPQRGTAGGTGKKSQPSLSAETQAQKRAEAEDYKAKANKCMQRSFFGKPDPVAASTFFKRAADCYQILQETRLEQLYRVESAECNRIVQAWASCASDYTRAAELMLELIDTTDNGTDASQKRRDASKFHKQAAGAWTEMGEKSKAAASQVQAAIALNFGEESTVLSKQALQGMEEAIEAHVPDVLNPYGRYRQTGVSAFLDPENADETVEQASAETLQLASSHMVTRSYAHEPLNQLVAVLVNAGEYASALYAAGAVTAILEKDGISTLSLSRAYAVETVLTLALGDPVMAEQSFLSRHVQSTPYLASRECKLAEDLFRAVKTRDLDALEEARAVTGSNRAALANLDPAVRELVPLLRLTGVARKNVASNAIPVASTSANSRRGGKNEPDRLQKNEIPEATTEPATLQELSKMKTGYEKEVAEGAHLDGNALANELDDLDFGALDSDHEDDGDGLGGVGDDSDLEDDDDVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5V9</accession>
    <name>B7G5V9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182612.1">
        <property type="nucleotide sequence ID" value="XM_002182576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5V9"/>
    <dbReference type="PaxDb" id="2850-Phatr48067"/>
    <dbReference type="GeneID" id="7203449"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48067"/>
    <dbReference type="HOGENOM" id="CLU_512407_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5V9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="521" mass="56955" checksum="3AD2C5FF648FA4DC" modified="2009-02-10" version="1">MSNNDLESQLKELSYHDQLEEKIRHSTTQTTVSMIEKQEKAEDRNVETAQRDSEALKTSINSHEATLHSPREASSRSFLAVATASSPHPLRTSNRNSQSPSFRNRDHPWKKDVIALSPVGWRRQVEAMLHCCDESPSRLQKRDADRLSCEKIEAKAKPIGQALENTDEKCKLVDKVAQSLVPFHDLVTDPKPAIDNLAPTPSGGLPTLATDGDSGIVACSSEDSILDNGTPALSPKESLLDDSTVSAAETLLDGDPVSSKDSLLDGASTESFVRKSSLTRLTNFLKDQPQTKPLDDAFAVLKPKSEYNERPRAGASAVLKFWSSTSTEEEEETKSGIDKDGDAESMDPFSVNPPIKSLSVRESPLRNETKPPELDPFSIDAVAALEVSRAQHYDREPSTFDPFWEETTSEPAVDFGGGNNFFSSTPDPFADFDVPSKRSSLPVRESFSPPIFTVVASHGDPNNCQPGGQTEKFSRLAPPSGSMDSASDIEPHVWSFEVDDPFAMDHQAKPVSTPKSVSCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G613</accession>
    <name>B7G613_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182495.1">
        <property type="nucleotide sequence ID" value="XM_002182459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G613"/>
    <dbReference type="PaxDb" id="2850-Phatr38494"/>
    <dbReference type="GeneID" id="7203276"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38494"/>
    <dbReference type="eggNOG" id="ENOG502SKWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519248_0_0_1"/>
    <dbReference type="InParanoid" id="B7G613"/>
    <dbReference type="OrthoDB" id="40923at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="312" mass="35085" checksum="F92E6D5386B05A9E" modified="2009-02-10" version="1">MTPSDAAKAAASHIRRKVLTQMASGIGVVSVPVAVWWYLTYHERQAKLEDVRTRVRVPNVQDTDDLLVEKCQAGDVILFDRRCEKVAAGPWAAISCLASRTFLCDDKKLSSRTVAEGKFDHIGLVVPGYIKSRHDALDASNLLLLEPTPSGIVARDLKTRLEVSSSRSVVLLQLCSPGEKRNVEEDYEQSIPVVRARKHVETELRKFRDRWIELGKDRNYKYMHSTLGLGGALVYGMGMQDMLSGPVSPSAYLVLIGLQQAAAAQNINDRENRAIKVEDFLRDHRFEERHAVRLRPGWRFLAPIPLRETSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G671</accession>
    <name>B7G671_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182674.1">
        <property type="nucleotide sequence ID" value="XM_002182638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G671"/>
    <dbReference type="STRING" id="556484.B7G671"/>
    <dbReference type="PaxDb" id="2850-Phatr48160"/>
    <dbReference type="GeneID" id="7203498"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48160"/>
    <dbReference type="eggNOG" id="KOG1273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406277_0_0_1"/>
    <dbReference type="InParanoid" id="B7G671"/>
    <dbReference type="OMA" id="SEECAHA"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="74431" checksum="AB3B25F3A961E6CF" modified="2009-02-10" version="1">MNLELLDPFGRQIPDRVDSTLSMADPSFHFRRHELLEAHTVPPSKKGRAVLVDPEWQAAYHVAFNRRGTYLAVGYGSGAVGVHNVLSRTLSALYPNDDLPEVELDLEDTKRLGSSKNSQKAKHKSKNISNAQEASSKATTRRGVTSVSWSRRSRSLLVGAAGDATVRLWDTTHPYGSEECAHAIAAQVQDHTGGTNSTNTTSNNQTSATHVSSQNGGDDDASTEKRLSTSPHGRKERQSGLADDLPSAQHATEQTAATAFNDADDRYVLVQNTLALDILPVTENRTLPEQRWLPVDAIPTWSSNSRLCKSPAVSWSFDVPIGGSLQVHPRIRTCGLAALTDGTLVVFWMPANVWTHGKVVDDDREPSNDDQDAVPLYEQAKTLIIPLWDDTDEHFITCASFHPHRDRVYAATKEGTLLGWDIESLLQTLQSYTGVQSVTLPMVYPRFAIESNVSSAAAWYLLVSRNGKHIVVNCANGSLRLYATNECWETPDAVDKPHWVFQDVVNKVKFASCDLSGDGEFIVGGANGDDNKYEVYVWNTSTGALMDKLTGAGVSLYAVAWHPARTFLAVATSDGLVDMWGPRVNWTAFAPDFQALPSNVEYVEREDEFDVDTNGRFLADLDAKDQFDDDEASDVDVLTVARVPVFASDSEEESEVFTFPTRVRSGKWRVAKAATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6S0</accession>
    <name>B7G6S0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_38760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182779.1">
        <property type="nucleotide sequence ID" value="XM_002182743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6S0"/>
    <dbReference type="PaxDb" id="2850-Phatr38760"/>
    <dbReference type="GeneID" id="7203797"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38760"/>
    <dbReference type="HOGENOM" id="CLU_907513_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6S0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="318" mass="35468" checksum="B384366AC89B6A5C" modified="2009-02-10" version="1">MPSTTSNNASEFGVYANLSSYKYEGDMKTKSANRGGDVNDMTVYKHYSKMSIRNSGSDADSTDDDDDDECSVPCNGRVYAKNIEPVYGFPTEEKLGEMVVSLPEPIDGQLLSDRKAFAPCQEPEKLTKVLMESKHGFLGRRSSIRVADSNGQPFSGGVHLKAFQHNVFRNSFLLRTARKTPVALCIQQRPAGPQIYHIYGTRPVHSNDVSRPVKERGVNYYLWFRFEEGGHRLDDRSISAWTGKGFVPIWKLVAACYHVDMDDSQPIKLNEIMIQGIEEDRALATLVKNECWEVTMAPGVDPALVFCVGAILEDSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7H0</accession>
    <name>B7G7H0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_38978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183145.1">
        <property type="nucleotide sequence ID" value="XM_002183109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7H0"/>
    <dbReference type="PaxDb" id="2850-Phatr38978"/>
    <dbReference type="GeneID" id="7194753"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38978"/>
    <dbReference type="HOGENOM" id="CLU_387087_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7H0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="267" mass="31098" checksum="7276DFEFA60B539B" modified="2009-02-10" version="1">MRTTKQDVLSPTETSSQWKFAEEERLMQDKYNTEEEEAKMSMEPESHKDKGFNEMTGNPDPREDVLQKYHDVLIRKNRNGWNAMEKPSIQDRKGLGGLIKRNSVPTRVGNRKSFKWKQAIFDIMVNLGIALGFIYWHAMKDLDKFRKLLGGHCLTVNNEIGQYIGVKTTEYEEESIRDHELEIWEEAKIFSIPGYHEEFHKGNEGQSVSKKQYSLLIGKIVFLVSKWITDCMTALRELSTFLDTVKWKMKSSNREDVKFGSQVGHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7T4</accession>
    <name>B7G7T4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_39093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183201.1">
        <property type="nucleotide sequence ID" value="XM_002183165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7T4"/>
    <dbReference type="STRING" id="556484.B7G7T4"/>
    <dbReference type="PaxDb" id="2850-Phatr39093"/>
    <dbReference type="GeneID" id="7194811"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39093"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="InParanoid" id="B7G7T4"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="352"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="552" mass="61695" checksum="0D660433490FB261" modified="2009-02-10" version="1">MTTPEPQESHAAAKNRTHRRRSSVSEAHQIYLQYHREAHHDDGSDSRKATQISTDGSTNKAPKRHDSTESRDHKPVTSFPMFHRVQKTGVIYATSRAAARGFQGDGDPSSEWANMGQGAPETGPLPNAPSRNFTMHIPDAELEYAPVTGLTPLREKVADYYNFLYRQGKQSQYTAENVCIVPGGRAGITRIMAVLGTVQVGYFTPDYTAYEQALGLFLRVSPSPLLHRDVTEACMSPEEFDFQCGGRGCGAILMSNPANPTGQSIEGDDLRRYVQTARDHQTAIIMDEFYSYVISLVLACATEAGCLPGTHEDFLFENAISHYYYDGPDQPLDGNTNDLHSWPKTVSSAAYVDDVDEDPILIVNGLTKNWRCPGFRVCWIVAPKPIVKMLGSAGSYLDGGANAPLQRLALPLMELAFIRRDAIALQQHFRQKRDFLLRKLEELGIKVKFKPTSTFYVWADLSGLPPPLNDCLVFLEECTKHKCICVPGVFFDINPRGIRNIRMSKCLHHVRFSYGPPMENLTKGMELICQMIQYWKKCPEPPDAYATESFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G830</accession>
    <name>B7G830_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183247.1">
        <property type="nucleotide sequence ID" value="XM_002183211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G830"/>
    <dbReference type="STRING" id="556484.B7G830"/>
    <dbReference type="PaxDb" id="2850-Phatr48677"/>
    <dbReference type="GeneID" id="7194910"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48677"/>
    <dbReference type="eggNOG" id="ENOG502RCV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1028407_0_0_1"/>
    <dbReference type="InParanoid" id="B7G830"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="34235" checksum="EAF4B73FAC31688C" modified="2009-02-10" version="1">MPTNLSSNQLGTDWCTYKTIGSRSPDRLYGSPRMTPAGDKATTMEKLVSPPVKKWVEGLTRALQDESYCSSHDEAVAVAELLFEHEAPDDDACDQGGLFALKESHRQGFSDYLGLSKTESAEIMAKVRRRVCGDPKPEESNENEQSISSSCLSEGEEQFCISSGDEDGMPVIGEGECELCEREIKLTKHHLIPKSTWARLEPKFRNAWVEWHENSNEEKAAVWVGPLLVKMLDAINENSSAAVKDAFQSWTCNICRPCHSMIHRTHDNYALATEYSTVESLLRDENIYNYCRWANKQRAGKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8F2</accession>
    <name>B7G8F2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_54952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183457.1">
        <property type="nucleotide sequence ID" value="XM_002183421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8F2"/>
    <dbReference type="PaxDb" id="2850-Phatr54952"/>
    <dbReference type="GeneID" id="7195109"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54952"/>
    <dbReference type="eggNOG" id="ENOG502RYPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053419_2_0_1"/>
    <dbReference type="InParanoid" id="B7G8F2"/>
    <dbReference type="OMA" id="LMNEMSM"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF24">
        <property type="entry name" value="OS07G0573800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855552" description="DUF2470 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="4">
        <location>
            <begin position="96"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="3">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="44101" checksum="FA2CAAEE5022160A" modified="2009-02-10" version="1">MSRSCLVVTTLLLAVLVAVSLPGSTDAFGSVRIVVPRTSVPMQSTIPPLPYRSSLSSSMATAVNGGDSSTASTANGAHDDANNNETFTPNLNIRLNVSEKARTVTSVCVSGTLCTVSVHEGIAGAPFGSFVDYVLDDQGNPVLLMNEMSMHTINIQNAAQTLLDASGTAIGPGPSMVTLFTQLGSGTTSLSPPRTAAGGASGTAKSNNLQDVSRCSLTGTLYKIDPAVDSDVDAIRMRYSLTHTYADQVMDSPKFAFYRLVPEKIYFVGGFGVMAKWVDPEDYAAAAPDILAKEASAIVAKLNREHGEDLQNTARHLLRVETPLEDIRVTNVDRLGVDLRVTSQKGSRRNKLQTDEFRIGFRIPVISVEDAKSEILKTFQEAWEIGNGMDWGEANGSDGAATSVPILKIAADGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8J7</accession>
    <name>B7G8J7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183354.1">
        <property type="nucleotide sequence ID" value="XM_002183318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8J7"/>
    <dbReference type="PaxDb" id="2850-Phatr48837"/>
    <dbReference type="GeneID" id="7195136"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48837"/>
    <dbReference type="HOGENOM" id="CLU_559576_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8J7"/>
    <dbReference type="OrthoDB" id="41177at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56626" checksum="E6D445A35A3F5B66" modified="2009-02-10" version="1">MTVSSLGGTLEFDLLLGVFWKRHSRCRTMVLPERRQHPIRRRSLLRATHFLCHPFRIIFTALWCFYVFYCFRYGDVSNGNGAYAPPIHENQGGNHTGASNPHYSSTVIDGKRNDFVSPQYDRSVETVAFNTTQQYIKYNKRGRAVVKAITRVRLEDLTDLPESLLAKANATSPALPDPNRADKEPILRMLRQAGITDVDPRVITLLPSWRDVTDLYGDDVPIVGLDEASCRWFRDTVPLRDAYLGAAGLFNTGTNALTYYLRANLLLPFRGEAPIHRDGKDSNRQGILTQVPWDKHWFARLRNHHTVDLYANVTKAHVLPIVMIRDPLSWSQSMCQQPYLVRWRGRTVHCPDWREPVLIPHMTGGHHWDSLWHLWNDWYRDYWQHENPRLIVRFEDLLWRPQQVLRAIQSCVGATWTTPGTFYYVVDRSKWEHVKTFRAQSNMVSAMIKHGTPSQRVRNLSLEELEQARQILDPQIMELFGYSVPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8U3</accession>
    <name>B7G8U3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_15301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183406.1">
        <property type="nucleotide sequence ID" value="XM_002183370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8U3"/>
    <dbReference type="STRING" id="556484.B7G8U3"/>
    <dbReference type="PaxDb" id="2850-Phatr15301"/>
    <dbReference type="GeneID" id="7194984"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15301"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_3_1_1"/>
    <dbReference type="InParanoid" id="B7G8U3"/>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC45106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="45235" checksum="22A2D6D9095B3977" modified="2009-02-10" version="1" fragment="single">LCNRAAAHSKLGYFSEAILDCSVATKLDPQYSKAYIRQSKALVQLGRFSEACNVLNKGLQYRSTPDMLREQETCTNLKLQYEIAMFQLESQNFALAKITFGNLLQTSWANVVLLGVARADLGLGFVDSASRFSLQVLKKSPQSAEAYALRGHSFVLMGEFEPGIKMLRESMRLDPDCTRNRLVWKECKKLQSLWDDSSTKTFHRKFECAVELMTEAIESCSQLPPKAPLFALFHVKRAKGYLRLKLFDEVLKDVALVIYNREDHIDAWLIRFQALHALERHEEALSDATDLMGSWGQNHGQIRLAFDTADFTVRKMKRPNFYKMLQISEIASEREIKRAYRQKALDLHPDRLSGSQYTSEQRRNAECEFKLLGEGLEILADEFKRQLYDEGYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8V1</accession>
    <name>B7G8V1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_39510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183655.1">
        <property type="nucleotide sequence ID" value="XM_002183619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8V1"/>
    <dbReference type="PaxDb" id="2850-Phatr39510"/>
    <dbReference type="GeneID" id="7195345"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39510"/>
    <dbReference type="HOGENOM" id="CLU_002237_1_0_1"/>
    <dbReference type="InParanoid" id="B7G8V1"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65346" checksum="BEB0C2C3D9B7E4E1" modified="2009-02-10" version="1">MSTSAHFKLSDFPHKVLDPIATLTVPPTYATIKRAQRQLMTNAAAIPTLNGGGAHGHMALTLTALAYADISDVPFVISVAPLANPPPGATQPQITENNRIHQRDADIDNLYVAVNNALRQQLLDAVPRIYVRALAHPMLEFSNVTCLDLLLHLWTKYGTIKPPELQKNFQSMYTPWNTTEPIESVFLQLDEAIAFSVDGNDPISEAAAVCAGYEVIAHLGLLPLDCKEWRKLPTAAHTLAHFQQHFSLADEDRRLTATTGSLGYANQKPAPYKRHMQEQGPWPWCQALDSGHLATFPELSSRQVRKYPPSSPAMVKGHLDQQRANLRSTKLPPVGSPIPTEPPAAAVPDLDPPDPPPPPVACTHHVFVAHQRVTGQIYTDQPGRFLTPSSAGHNNMLVLYDYNSNAIHVELMRNKSGPEILAAYKRAHALFTQRGLRPQLQRLDNEASTALQSFMTSEHVDFQLAPPPPHLHRRNAAERAIRTFKNHFIAGLCTTNPDFPLHLWDRLLPQALITLNLLCRSRINPKLSAHAQLHGAFDYKRTPLAPPGTRVLVHVKPAACKTWAPHAVEGWSASIILQATRARWLWPSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9P2</accession>
    <name>B7G9P2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_49158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183926.1">
        <property type="nucleotide sequence ID" value="XM_002183890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9P2"/>
    <dbReference type="PaxDb" id="2850-Phatr49158"/>
    <dbReference type="GeneID" id="7195655"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49158"/>
    <dbReference type="eggNOG" id="ENOG502SCCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571732_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9P2"/>
    <dbReference type="OrthoDB" id="197666at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="462" mass="51628" checksum="BC60012958D9AE98" modified="2009-02-10" version="1" fragment="single">MSRNRSRIPRRRYTWPKAAVVMTVMGWGLLLLVCTEAAQSSSSPSGTNTTRSRSTATGTTDESSTSVTRVGNLDYLDAATMAYYLDAPRWTADHPEHDVVVLFYAQWCRNCHAFAPLYDQMSKLLHAGTKDSQLVMGLFDCEQDKAHSRVCSDAGVTHYPTIMFLSSSGQVLQRGRRSPKVPLPKHITTFRGNWQYGDAVMDWIKTLRGLSHWHRAGWGKTLRNLLFGRRHRDPARERLPTGIPSGTNRRDGTTTAGNGATHASHEQQELRDEIRSLSDLVIRSSTIVDALLFPVTAAANKTLSTNVIRDENAKNYTDVFAFLRDAWHSNRTSHQVIRTCAMEVALDYCGRLNTHVTEDWLTAFPSIDRITEADLNLFRNELPKLVAKQEPYCAVVEDCIVGDFAEEHCRPAACPFVDPAACRYLTCCLTEQVYEEYAVAMDLVENVTAGTSANIDAADKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9S4</accession>
    <name>B7G9S4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_49189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183940.1">
        <property type="nucleotide sequence ID" value="XM_002183904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9S4"/>
    <dbReference type="STRING" id="556484.B7G9S4"/>
    <dbReference type="PaxDb" id="2850-Phatr49189"/>
    <dbReference type="GeneID" id="7195673"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49189"/>
    <dbReference type="eggNOG" id="ENOG502R8RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1457179_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9S4"/>
    <dbReference type="OMA" id="HQHIFET"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20213" checksum="8766CA465B460C90" modified="2009-02-10" version="1">MASFLFKSAGVALGATYVEKLYGPKDPENLFGATTVLLIGTGLWSVLHGMKVGKARSKYMELATKDGEEDVEHRYALPNLYVQGISKHARAFNAIQRSHQHIFETFPQLALSAMVGALNFPITAALSTLVYVAGRVAFSNGYANSEGDVSKRYSSKLAPYMWYGLLVNFAVGIVSSIKIIASKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9V8</accession>
    <name>B7G9V8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183842.1">
        <property type="nucleotide sequence ID" value="XM_002183806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9V8"/>
    <dbReference type="PaxDb" id="2850-Phatr49221"/>
    <dbReference type="GeneID" id="7195687"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49221"/>
    <dbReference type="HOGENOM" id="CLU_668123_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9V8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42738" checksum="13EE267FE954FABF" modified="2009-02-10" version="1">MIEKKDSDFDQTVSSRDEPIMDVPILVLKDLQRDGTDTADQAIRQGMDLGCLWVDIGDGCDALQDTGVLWSHVESFFNTARDAPHWKSSRFTAPQDPYLDALMHSVYVSGSHYFSRPSFESSTIFPDDAASKAPECLADIDPLLFQVQNVMVDAANQIFAYIGERVLGIEADFLAAAPEKRTNTLTLHRVAPVAEEEEQKTAAQEHFDFNVANVLLYNYCRGFKIYRDKVWYQLAEPTKPNLLLFDFGSVVSIRSNRRVAALFHRVDSPILTEDERAAWGSRLSLVCPIVPALPQEIETHPKLLDESIDGGKSPFDRHTYRDHVFYASKHYTMLSKHVVFDDPNYNKAVSFQMRGAAFSVLRTKFRATWGSLFGQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GA23</accession>
    <name>B7GA23_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_39949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183995.1">
        <property type="nucleotide sequence ID" value="XM_002183959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GA23"/>
    <dbReference type="STRING" id="556484.B7GA23"/>
    <dbReference type="PaxDb" id="2850-Phatr39949"/>
    <dbReference type="GeneID" id="7195564"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_39949"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881283_0_0_1"/>
    <dbReference type="InParanoid" id="B7GA23"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="132"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="300" mass="33565" checksum="B484F6A51640BA51" modified="2009-02-10" version="1">MDEETAVEFLPLQPRVSFNTSNTAKNRLARSSSTESSSPSWDIGTSSRPLVQQALCSILFGLFGWNFPRYLISIETTIQHNVPPFQKTQAGDVILDFLLNQNLTYPPTVGLMAAWSFAPHRPAHVRWHDVHASFCGLITAVGLSEGATVLLKLYIQRRRPNFYALCGFDKQLLQCTADLEKIREASFSFPSGHSSLASCGMTFLVWFFLGKILLSRWNRSTTRILCAGACVLPWGWAAFVGASRLVDQWHHPSDVLAGLLLGGLSSTIVYHIWYHPTWSDAAGHPWSLQPNERKLESFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAI7</accession>
    <name>B7GAI7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="6">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_49417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="6"/>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184081.1">
        <property type="nucleotide sequence ID" value="XM_002184045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAI7"/>
    <dbReference type="FunCoup" id="B7GAI7">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAI7"/>
    <dbReference type="PaxDb" id="2850-Phatr49417"/>
    <dbReference type="GeneID" id="7195794"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49417"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559622_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAI7"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="41525" checksum="9B15458494345E70" modified="2009-02-10" version="1">MDSHASDDAIVLTANDAWSAKFAAVDKGYYWDAFLPAFATVSHGNRQSHRHVQPIIKRGTHARVCCMDRAVTSFVELVVARRDPHSPIQVVVLGCGKDTTFFRHQEGRLTSVGGDEKNAAPNTNSEAPSSSNKVHWFEVDHPAVIQEKASIIRANPSLFNSSVEKRTSNCHFRIKPDIYTSYESECTLLGHDLRNDPEGLMLALASNGLRADAPVLFLLECVLMYLPEIATKSLIAALPRHFPQACLCLYEPILGSDPFGRVMEQNLRHANVAQNDSCLVQTRTLAQQMQKLRSAGFNGNVVGCDMWAAYESIVTATQRAQANRSEFLDELEEWILIMRHYCFVVACTNAASGLGEQLGAVGPQSVLGFATGKCELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAI9</accession>
    <name>B7GAI9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_49419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184204.1">
        <property type="nucleotide sequence ID" value="XM_002184168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAI9"/>
    <dbReference type="STRING" id="556484.B7GAI9"/>
    <dbReference type="PaxDb" id="2850-Phatr49419"/>
    <dbReference type="GeneID" id="7195910"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49419"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810047_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAI9"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="343" mass="38784" checksum="9E9C4FCA698407AC" modified="2009-02-10" version="1">MGRKRKRHNQNQGHKKRHEKEKYWINDCKSSKDGNYDFCLWITRSYLSDNYQQLHASDSLTECESDAHILSEKDLAHRISTPTQNAYIVDQRAGVPFNSQADTTSKVTVLSAPRIEERSLKPSIRIRRTGSADKPLDVSSNEHFSLLANGDCGDGICNPYRQTEVADKYWAQRKRLFTKFDKGCKLDRDGWFSVTPEIIANHIAQKMFHGHHDDKAIVLDAFAGVGGNSIAFALRPEVSLVICVDIDESRLCFAANNCLVYDIPREKIVFILADAMDVLARYKSGALASCLQHLSTKESPVHGKRFSADYHGYRYGGVELLPEKLDAIFLSPPWGSPEWTMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAK6</accession>
    <name>B7GAK6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184210.1">
        <property type="nucleotide sequence ID" value="XM_002184174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAK6"/>
    <dbReference type="STRING" id="556484.B7GAK6"/>
    <dbReference type="PaxDb" id="2850-Phatr49434"/>
    <dbReference type="GeneID" id="7195921"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49434"/>
    <dbReference type="InParanoid" id="B7GAK6"/>
    <dbReference type="OrthoDB" id="41738at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="418" mass="47918" checksum="3066A3E162A05A40" modified="2009-02-10" version="1">MSELGRQRNQETMDELEERRDSELAFVSAAYTPDEAWYNVEATENGALVNGVVGTVHRRLFVPPYYCNSKEEIACFVLSLSMTISYPEEDALQVHGRVDSERTSRLLLRASHKALRALLDSCQEMAQSCSGQESVLLLFNHVEQWLEEKWTEYLKEVRSKSPEITSERKSWAAAQEQPKILGRRLIYSHHIISKTKRSNIKDIASQYDLTGFMKVGWPGLLIVEGDEANCCDFYEEIRRWAWQYLVLRGEMQEEFETQHAMTCARAFAIFSEVEDMSIVASACREAGLESLFQTAMKIYEHDIQDNEHHIHGALILVDHMNDGKAYRKWLRKNSRSLDVSLVVKNIYADNDFTKRPTILVAFVGDNITVPSQLSRTPSTRVDWEDSCSENVNIEKDGLLRLLEDINGAPWVDIVVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAR8</accession>
    <name>B7GAR8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184242.1">
        <property type="nucleotide sequence ID" value="XM_002184206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAR8"/>
    <dbReference type="PaxDb" id="2850-Phatr40199"/>
    <dbReference type="GeneID" id="7195715"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40199"/>
    <dbReference type="eggNOG" id="ENOG502S1BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951534_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAR8"/>
    <dbReference type="OMA" id="YWAKRIA"/>
    <dbReference type="OrthoDB" id="3155at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF4">
        <property type="entry name" value="DUF1995 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855648" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="43"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="291" mass="31982" checksum="7BECE9EC26CB2356" modified="2009-02-10" version="1">MKWHSTSFLLLTVNVYICSTNAFVPLVDGGKNMPALYNGWMNDQIAKQASTAVGKAIASGVKQIEVNFPPVPNVEEAKFGTPLNQLFGTKVVAREIGFTGGYKPGSDVSRQLIAYSNMYWAKKIAPAIGGGIMGGSKVTVLTAEAVNLKLIQNSGVGRTASLSPRASQEFQNEAVIVVNPGGEEQWERIRAVHASDDIPFVILNNAYSTTYDLGNKRGYEEAYFLKRISKGWVFRAFPGPWQAYLEKPDGNVELLASYKIKPSLKEVATAVREESFKRYAMGNDRWMSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAS5</accession>
    <name>B7GAS5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem II subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PsbM</name>
        <name evidence="3" type="ORF">PHATRDRAFT_55057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184128.1">
        <property type="nucleotide sequence ID" value="XM_002184092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAS5"/>
    <dbReference type="STRING" id="556484.B7GAS5"/>
    <dbReference type="PaxDb" id="2850-Phatr55057"/>
    <dbReference type="GeneID" id="7195719"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55057"/>
    <dbReference type="eggNOG" id="ENOG502SEWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2202160_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAS5"/>
    <dbReference type="OMA" id="FAPNKAP"/>
    <dbReference type="OrthoDB" id="40270at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007826">
        <property type="entry name" value="PSII_PsbM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03038">
        <property type="entry name" value="PS_II_psbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856032" evidence="2">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="108" mass="11103" checksum="5E100AF9B0DE3949" modified="2009-02-10" version="1">MKSFQLLTLFALIAASLAFAPNQAPQQVAKAAFTKAAGALPVAALAAPAFALDSIVEALPTNTVALEVQFGAYLAVALGTLLPCLFLINLFIQTESRKAGRAGGQDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAV6</accession>
    <name>B7GAV6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_23286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184146.1">
        <property type="nucleotide sequence ID" value="XM_002184110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAV6"/>
    <dbReference type="FunCoup" id="B7GAV6">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAV6"/>
    <dbReference type="PaxDb" id="2850-Phatr23286"/>
    <dbReference type="GeneID" id="7195848"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23286"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAV6"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="274" mass="29284" checksum="28897B9670058B84" modified="2009-02-10" version="1">MSSSIRRTDLLALSNLRNDGRKPHEIRRMRVQMSPLSVSTISGSALVEMGLTVVLATVRGPVDCLRRADENPDQAVLDVTVQSAPFSSSADRRVANPKTDRRLIEASHMLKRAMEAAILLHLYPKSRIELVVSVLADDGGRLCAAINAATLALMDAGIPMKDFVCACSAGLPGTSATPDSHALTLVDLNRQEESSTGGQAATHMPVALLPQRNTLVLAQCEARLPNLDTLERVLDAATEGCRAVFDILQAAVREHAATVLAARSGTTRIVSAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB40</accession>
    <name>B7GB40_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184397.1">
        <property type="nucleotide sequence ID" value="XM_002184361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB40"/>
    <dbReference type="STRING" id="556484.B7GB40"/>
    <dbReference type="PaxDb" id="2850-Phatr49580"/>
    <dbReference type="GeneID" id="7198198"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49580"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059028_5_1_1"/>
    <dbReference type="InParanoid" id="B7GB40"/>
    <dbReference type="OMA" id="FKFAVAC"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853082" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="96"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="27609" checksum="C16EC56A6470AB87" modified="2009-02-10" version="1">MFRKSLLACCCLFLQYKSASAFRGRFLAKRYATAADSTVLQATKERRPWDFVRFVTQSSKFVSIFPTRTPTRMVKPGRVLWDPKGDGENDFTLAPLDDVVMGGASSSTFSFGRWKGTVTDANNGGFIGIRSTPSFLFDMSACEGIEIKLTSDDTQRRFKFGLRDSKEFNGIVWTASVDVRGSKAVRVNFNKLVPTLFARTVPNSPTFKKDNVVGLQLIYSKFEYDGEMNPNFTLGDIDVAVSEIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB69</accession>
    <name>B7GB69_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_40349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184414.1">
        <property type="nucleotide sequence ID" value="XM_002184378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB69"/>
    <dbReference type="STRING" id="556484.B7GB69"/>
    <dbReference type="PaxDb" id="2850-Phatr40349"/>
    <dbReference type="GeneID" id="7198215"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40349"/>
    <dbReference type="HOGENOM" id="CLU_1380497_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB69"/>
    <dbReference type="OrthoDB" id="47882at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC44163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="198" mass="22652" checksum="168E477851D10058" modified="2009-02-10" version="1">MFVRTRFRKAFHFRSCLVSTSFHIFPSRKLSFSASQNAFQVLGLPPGSPYEKVKRAFVKLALEKHPDQEGGSAEAFIAIRGAYEAIRKEISEDDSSENHADDPSAYWSPAELQEWFQRETGAFLSFEMCDKTRKEVINVYKTMSHGGKDKGGYWDMARTLAEQEERRMASGTRERTGGLPSQLIGPQSSTFNRRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7GB82</accession>
    <name>B7GB82_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184322.1">
        <property type="nucleotide sequence ID" value="XM_002184286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GB82"/>
    <dbReference type="PaxDb" id="2850-Phatr40362"/>
    <dbReference type="GeneID" id="7198279"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40362"/>
    <dbReference type="eggNOG" id="ENOG502SPJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525303_0_0_1"/>
    <dbReference type="InParanoid" id="B7GB82"/>
    <dbReference type="OrthoDB" id="45213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853085" evidence="1">
        <location>
            <begin position="17"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="561" mass="63284" checksum="670FD65BFA6DFD34" modified="2009-02-10" version="1">MSTYFVAFAFIIWTLALWRHVSRRAAFISDPDRRLPSPLWHVPVASSHGDHNDPMTTPTNVSRTVESLLSLRVGDLPGYTGWARPVGTLSPYFRQVSDAHGRPTRTIVTVGRVWTVRVACTGHVRCFRPQRAILDVRAYGPSVVAGMVVPSRVRRAYDPSNTTASHDTIPGYYDVQIVFPDAGVYHVEVVLAFSNAPAWNEFPLAGPEPDYEGYLLPDFPLTVVVDPVELVSEDPTTHASQDNRPVCTNADLLETSPTSAIIKGRWRVSDKVQDRRLVEDAYEIDHSPSNISRTGYEQGVNSLGITMAFEYQKCKLATVHQSKRILMVPKTKDWYILFVGDSNMRAQHLTFQSWHGRDRNQYPQSGYISTAKGLAKQLPQIREKLSALKKHATNRTEFYVLFNAGLHDIARLCSRKWSHERFNNGDTRPCVEQYRQHLGELINGIKDLSPKLAVLQTTIAGWPKWGNFGFAWPPSQGQPLPFHSSTCQSFNEIAWEEATKADISVMDAYWLTVPRPDHRQVDNENAIGKHMVHVGPEIHSVMQRKWISLIEIALGNDNPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBP4</accession>
    <name>B7GBP4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_49725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184482.1">
        <property type="nucleotide sequence ID" value="XM_002184446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBP4"/>
    <dbReference type="STRING" id="556484.B7GBP4"/>
    <dbReference type="PaxDb" id="2850-Phatr49725"/>
    <dbReference type="GeneID" id="7198405"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49725"/>
    <dbReference type="eggNOG" id="ENOG502SBZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687876_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBP4"/>
    <dbReference type="OrthoDB" id="44964at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="401" mass="43955" checksum="0AC1D96CE7A097D0" modified="2009-02-10" version="1">MLDDFGNASEVAIFWDYENVPVPSWCKVASEASKAIVNSVSEQGRIVDRRLYFDFSNQEQGNRWSGLDSSGFDLVNTPQRNQKETLDKKMIADVLLFCWDSATRNQGTNKGSCVVLVTSDGDYAYTLNKLRDRGVSSVVIYGHGNVADILISSADVALSLKHDVLKHLRPPLALPNGRPKNVQDKTVSRNPHLKIVNGKPAYHLDSRVVPRKPTQQSESQASKRTFDCNDKSTTHCSGSNLKTGMTSANDAGAANKHPNIKYVASPAKFTMQRDAILLCQSLADLAVSTAIAPEQQWVSESQAGQSFQKILKICKKEKDSDGDVTQCFQNAYSLAILLGWIEEGRRGLGGQNGYIAATSSPSREKETTETFLRLTPYGIKVASKRALILPVKTTTLVPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC51</accession>
    <name>B7GC51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_16376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184657.1">
        <property type="nucleotide sequence ID" value="XM_002184621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC51"/>
    <dbReference type="FunCoup" id="B7GC51">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GC51"/>
    <dbReference type="PaxDb" id="2850-Phatr16376"/>
    <dbReference type="GeneID" id="7198503"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16376"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_1_0_1"/>
    <dbReference type="InParanoid" id="B7GC51"/>
    <dbReference type="OrthoDB" id="37170at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="252" mass="29308" checksum="BA3C6ADBE22A2798" modified="2009-02-10" version="1" fragment="single">WMEERPWIPLVALFFYATGIVLGQAYFATRDAWNWRRTMALWNLSLSVFSFVGLLRVAPALAHNVWHYTWAENLCLDPESHFGSGSTGFWVNLFVLSKIPELIDTFFIVIHKKKLILLHWYHHISVLLYCWHSYVGKSPPGIVFCAMNYAVHALMYFYYFLMAVHRKPAWFQPVWITVAQISQMVVGVAVTVAGWYLMLVAPPAEGCWLSRENNLAALVMYGSYLFLFLQFFVGRYFGKRSKKVTNKTIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCE6</accession>
    <name>B7GCE6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184795.1">
        <property type="nucleotide sequence ID" value="XM_002184759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCE6"/>
    <dbReference type="STRING" id="556484.B7GCE6"/>
    <dbReference type="PaxDb" id="2850-Phatr49948"/>
    <dbReference type="GeneID" id="7198641"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49948"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035857_6_0_1"/>
    <dbReference type="InParanoid" id="B7GCE6"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="20627" checksum="2224625086029285" modified="2009-02-10" version="1">MWQKVRSIWATLYELYYEDFDWFHLGGDDMWVLVENLRMYLESDEIQAAANGGFSDTLPLGVQSGNNNSTRIQPDQVPLYLGSRLAFRNNTRTLYNTGGPGYTLNKAALKLLVTEGLPVMHSQLRTSAEDLRVAEVFRRFRVLPYPTHDRDGGERYHHFTPGLHQLSAMPEQYKWLAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCL1</accession>
    <name>B7GCL1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_50006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184892.1">
        <property type="nucleotide sequence ID" value="XM_002184856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCL1"/>
    <dbReference type="PaxDb" id="2850-Phatr50006"/>
    <dbReference type="GeneID" id="7198783"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50006"/>
    <dbReference type="eggNOG" id="KOG0632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377435_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCL1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF20">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C83" evidence="7">
        <location>
            <begin position="438"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="735" mass="82097" checksum="4C112709D99021D3" modified="2009-02-10" version="1">MEHSANGTKNASAFSTEQTRLLPARAVESPSDNDDESGYGADPYDALERQVRLTAVSTPFLRSPRRLLALIGTTILAIVVVIYTGSTTSRPHESSTSSSTRSSSPVEAEHSPKETMFSTLLTFATPWNDLDWKDLHNHDVLLQVWDEWKRSLRDDNRKNHDDRNNNDDDHNAMDWWHTIRVRAEPLLGHAKDSVGNTWHEAESAVQGTTSEWHVGEKLRSAQEATSSWAQQTGQQAQNDVRDWQLGLHLQQAEHAAAQLWNSTLQKATEVSSSMSASGGAVGKEWLGDTQDWLHAAWNGTEQTAEHAWGTVEDEAQRVGPQARTLWNHTAQTEGEWYNHVKNNLRHFGSKIRGWWGVTERAAVNETGAMEDTFQNWWKQANGKERAWWNDTVHAYHVLAQKSERAEASWWNATRETVGHGWNATTATTDEAWESTQRWFRARAHVTQNLEEPLLYLNSSRAYSLLRNAQYGWYEASSDFFEYQTGWDVQINQAYCGVAAAVAVWNSIRSSVVGANDAGAVEAAMDPSYEPYVYATQSSLIHNKCVHHKVIRHNATFDGILHVPGGLSLVQTADLLTCTLPSSLWTVTTHYVVANTTTLDDVRADLQQALLDPKARVYVNYDRSVLDQHGGGHFSPLGSYASRDDAFLLLDVAKYKYPSAWIPAARLFAAMSGIDVCGTWDYPHAQDSLPVSLLKANSTKAYARALTKLGCKPLPRGYVIVRSITEDTGNRSIVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCM5</accession>
    <name>B7GCM5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184901.1">
        <property type="nucleotide sequence ID" value="XM_002184865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCM5"/>
    <dbReference type="PaxDb" id="2850-Phatr50015"/>
    <dbReference type="GeneID" id="7198715"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50015"/>
    <dbReference type="eggNOG" id="ENOG502SSM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401427_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCM5"/>
    <dbReference type="OrthoDB" id="55966at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="686" mass="75576" checksum="DC5F8D167B656FFE" modified="2009-02-10" version="1">MISAVHPAFVLALTANDVLFGRGAPSIENEGNVRFRHLVQERKTEYVSTGKRQMKDWIARQVIQAVRLRQGRFLRKIESLVEAERMGVPEGTTAWTFVDETTILQKVKQALRDRDNNEAAPSGSPRKHPATEGAAPNMFPGVEDPTAIDLRQRANLLLHSSPAAGTVNLSSSAMPRAGLHAVSDFLRNQQQQQQHRQTDEHARAVLYSIQSSMRRGISPLLPGGPQVSAGVPGQAKPVQGLTSFLSPNLVGGFAGISTANTGHLGLDQQWAAVDRRIPEKLTKLPPASRRTYQEATYSHETSAERALQAAYQAAHTTASSIQKDGQSSISLLELLLLQVVASHGIPLWTATNIEDVFISNREGVLSWSRLGTSLIQATQRWFQQRQNEPEPALAQEHALSLSLFYAQEIPELARKIVTLLEKLDKVSQSGAKRKSSNEEEGNGHSLDVWFQQQLSLWAASLNIANNQGRPLPYATADFTTKCQDYTFHEAFAAASILDASKCRDVWQQVAVLTRLRSIVAANPATDLLTKLDYAQMQLAGQAWDSRPSWWAPSDPAATVVRRDVFLIERVLLSGYQHVTRDIETALPAGLTKASIEDRLTALTYRLHHQQMTADEQQILDERVVQHLASLQAHLPADAPVYRGVDGAGLDEVGGDGTVGMRHTLNTPQQPNPKRFRPGDYPPRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCQ3</accession>
    <name>B7GCQ3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184919.1">
        <property type="nucleotide sequence ID" value="XM_002184883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCQ3"/>
    <dbReference type="PaxDb" id="2850-Phatr50038"/>
    <dbReference type="GeneID" id="7198798"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50038"/>
    <dbReference type="HOGENOM" id="CLU_383332_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCQ3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="41659" checksum="91F7FF4C142EF39E" modified="2009-02-10" version="1">MNSSEYSLRLDESDAYTEPNDDGVGDWGSVLSWEGENNDGNGVPPRSRSVEAMSLAFQDKPVSQDSLQLSEEDQQNNFYSNYLQQEGLGEGAMSMQGSGEPFFPQNGKAGSQVGQQFRQLQTNESNKHQECDQAKQSSLPQISLGPCHANQEASEGLQPTQSLQQLRQVDHPQLLQQVRFQDDVRKQHQENPQVQQFQSQYTTDPSILLQQLQIAQLQQQLQFAQAQHQVSQATQQFCGSSVEVDNVQKYRHLNSKPSQNSSILPRPNQCYSDSVQCGSLSRPVDQRNNFGELPQEQSAKMDTVETTGPMHFSISKAPVVVSSSDTDDSNRKRTVPGGKGRVRTTAPAKRAKPQPLDTGNMTEKERVHRLRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDE6</accession>
    <name>B7GDE6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_50236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185117.1">
        <property type="nucleotide sequence ID" value="XM_002185081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDE6"/>
    <dbReference type="STRING" id="556484.B7GDE6"/>
    <dbReference type="PaxDb" id="2850-Phatr50236"/>
    <dbReference type="GeneID" id="7199014"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50236"/>
    <dbReference type="eggNOG" id="ENOG502SGUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1055449_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDE6"/>
    <dbReference type="OMA" id="RTSTCMA"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="264" mass="27078" checksum="7C5F4305A7FBA7F3" modified="2009-02-10" version="1">MATKFADLSKGPKDLLNDDYTSSVVLKAKKNAGPVAVTIETTRGDDGALTSKVGTKFAYAKFNVDKGQIKADGGRVLETSLKVTPEVKLSFLASKGADLGVDYTKGNFYGTGVLDVMDMSLVSTSACYGLNSGLKVGGDAAYNLSGSKGLSGFNVGASYTAGPLFTSLTVSSKSAATIGLLYKVNSDLMLASQTVHTSNKVCDVLGVGAAFKAPVGTIKAKFNSGGVVSACLIREIAPKVVMTASGSVTGADFSTFKPGFQIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDF5</accession>
    <name>B7GDF5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_55162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185122.1">
        <property type="nucleotide sequence ID" value="XM_002185086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDF5"/>
    <dbReference type="STRING" id="556484.B7GDF5"/>
    <dbReference type="PaxDb" id="2850-Phatr55162"/>
    <dbReference type="GeneID" id="7199098"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55162"/>
    <dbReference type="HOGENOM" id="CLU_643266_0_0_1"/>
    <dbReference type="InParanoid" id="B7GDF5"/>
    <dbReference type="OrthoDB" id="41194at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856051" evidence="2">
        <location>
            <begin position="25"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="437" mass="49798" checksum="239C772BBA2AB0BA" modified="2009-02-10" version="1">MHWYQVQMQFTLVLSFAICGLTQSGTSWDTVRLVPVEDPTQSPETSYRSEDDASFAIYSRNLSSVLGDKQTFYNDFMEGCRKAVMESGSDPDVVCDKDDGHRMRMNVYQPQSVVNYTKTGFAKVKTPPEVFRLLKEFWDLNKEKSYVEWSGPTPYHNNWEVPPTVIRVDNTTLETGGIELQRAISNAAKALMEEWTGQRLSYSSVYGIRIYHNQSVLSPHVDRLPLVSSAIINVAQDVDEDWVLEVYDHDGVAHNVTMEPGDMVLYESHSVIHGRPFPLQGKFFANCFVHFEPLGPLDQSEISVNNGDLPPYLIPGSQWEAEYRLKHPDGWSVLSDPMSLIQSGDLPLLRYVGRNKPEVLHKPDKIDWRPIHEVCRQGNLEILKYLVEQDADIHAVTKAYGNSEPLDIAKRYLASDDPVIEYLEEKLRAEESDHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDY8</accession>
    <name>B7GDY8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="9">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="9">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_31147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="9"/>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185340.1">
        <property type="nucleotide sequence ID" value="XM_002185304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDY8"/>
    <dbReference type="STRING" id="556484.B7GDY8"/>
    <dbReference type="PaxDb" id="2850-Phatr31147"/>
    <dbReference type="GeneID" id="7199156"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_31147"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GDY8"/>
    <dbReference type="OrthoDB" id="39028at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="11">
        <location>
            <begin position="93"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="559" mass="61224" checksum="6FF66E363CE54989" modified="2009-02-10" version="1">MLSNGSHQNVSASGDTSVPGQGWSNGALAPQLFPVTQQGRLQLYGSQRRWIGLQSGWTRIGAGQTELDAVHSRSQGTGILDRNDAEQAQAARSLIAQLCETFYRQGWATGTGGGVSIRVGGPSQNRPWRVFVAPSGIQKEDMIGDDVFELDMDRKVIVPPRTPNLRQSACTPLWYVVYKYRPTATCVIHTHSMHAQMATLLDPTETAQTLNVTHLEMLKGVGNHAYDDVLEIPIIDNRPSEDQLATQLQAAIQAYPKSNAVLVRRHGLYVWGDSWEQAKTQCESFDYLFQSAVQMKAMGIDSGLKPLQGTYREGEDKEDLVEKTILLLDIEGCTTSISFVKDRLFPYVRERLDSYLKGHVAASDKYQQLAKALAGEADAHSDSPVAGTIRQDVAGMVRYMMDRDFKSATLKALQGDIWKTGYARGELKGHIYSDFVPTCQWMQRHGVRVYIYSSGSVAAQKLLFGNSTEGDLLPYLSGHFDIPTAGPKKEAGSYTAIAQTLQVAPSAIVFCSDAEAELVAAREAGIGYPVMSVRPGNVPLSAEGRELPAIYSLLQLCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEN9</accession>
    <name>B7GEN9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_17115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185580.1">
        <property type="nucleotide sequence ID" value="XM_002185544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEN9"/>
    <dbReference type="PaxDb" id="2850-Phatr17115"/>
    <dbReference type="GeneID" id="7199428"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_17115"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494766_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEN9"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="216" mass="24708" checksum="2E06C825A5DA33DA" modified="2009-02-10" version="1" fragment="single">IAPMLHVSTREFRQLFRILSKRVVLWTEMVVDELVYHNHEDRSNGTLETHLGYDDTNEHPVICQLGGIVPSHTALATQLAVERGYDEINLNVGCPSDRVSGKREFGAVLMKQLSRLLLLVQAMRENAGDTPISVKCRLGVDDWDSWEVLEEFVDTLRPYCRIFYVHARKCLLQVLSPAQNRLVPPLNYPRVYRLCERFPDCDFYINGGIPGLRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3L0</accession>
    <name>B7S3L0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_bd1135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002176112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3L0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1135"/>
    <dbReference type="GeneID" id="7204807"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1135"/>
    <dbReference type="eggNOG" id="ENOG502SW3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_812523_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3L0"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="39092" checksum="6372C045E56A9746" modified="2009-02-10" version="1">MEETFSRPHEEGSGGLPPTLLPTKVYGSQPQYNRPFPYPEAPVRWQVGSILEWFESLAQAAEQGEFQNNFHLGNQQHRQPIGGSELPLADPVPLPPWYTQPVSNDEAVIDETSCNAVTPKNWDLSFVEHQDPWGWSDRQRMAKVACQVEASSSINCEKYHGIRTRFEFLFGRCVFQHSTPVEHGQRRIILRVLYEETIAKLRELLGNHQPPLHQIPDKILSESSPIATKQDLSKYMTAWLRENWTNPYPDDQGLATMAQACHTTPTVVNNWLINARTRKWRRAITKATNMHRPAKLLLEDSLRIFDGEEVRELGNLTMEISSSCSEANDMEGPMHKRHKSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N0</accession>
    <name>B7S3N0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999261">
        <property type="protein sequence ID" value="EEC42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176171.1">
        <property type="nucleotide sequence ID" value="XM_002176135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N0"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1160"/>
    <dbReference type="GeneID" id="7205018"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1160"/>
    <dbReference type="HOGENOM" id="CLU_1491847_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N0"/>
    <dbReference type="OrthoDB" id="49166at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="168" mass="19309" checksum="79699128A7097422" modified="2009-02-10" version="1">MPELKSFLKDGEAEWYVGVNVTYVTGRRAVMHIYNEGGSKVEVIDLTSEEAVEMPHEERQAGAREWRRPRKPRKIMNRDQEPALKEATLRKQQRHREPKLAERDLLGKTAPTVTSLFLLYGGLLATILATASCTSVRRRRTRRRRTMTIGEVRKGDAGFQKWKSVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3W4</accession>
    <name>B7S3W4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_bd430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS999277">
        <property type="protein sequence ID" value="EEC42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176254.1">
        <property type="nucleotide sequence ID" value="XM_002176218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3W4"/>
    <dbReference type="FunCoup" id="B7S3W4">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatrdraft430"/>
    <dbReference type="GeneID" id="7204978"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd430"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="InParanoid" id="B7S3W4"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="325" mass="36624" checksum="E00697166CA64C0D" modified="2009-02-10" version="1">MCSDAGTKSQSQHRFVDIGANLLEERFTKGTYRGKFRHEPDLEQILERASRVGVRRIILTAGTVEESRSAVVQARAWRDLYPSIDFTCTVGVHPTRCQQVFEDSEASSGDLLQELLEIAEDGIKDGTVVAIGEIGLDYDRLEFCPKDVQHKYLVQQLTILASKTALPLFLHNRNVGKDLYDVLQTHRDCWKAGGVVHSFDDTLELANDFIEDLGLYIGLNGCSLRTDDNLQVAQHLRLDRILLETDCPYCEVRKAHPGYQYIKTHFEGKSEKKFESGLTVKSRQEPCHIIQVAEIIAGIRHVPLSQVTEACFENTLRLYGWAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7S419</accession>
    <name>B7S419_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_bd1656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999283">
        <property type="protein sequence ID" value="EEC42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176298.1">
        <property type="nucleotide sequence ID" value="XM_002176262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S419"/>
    <dbReference type="STRING" id="556484.B7S419"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1656"/>
    <dbReference type="GeneID" id="7205144"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1656"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255821_0_0_1"/>
    <dbReference type="InParanoid" id="B7S419"/>
    <dbReference type="OrthoDB" id="43191at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="590" mass="66226" checksum="FF37C7C4F0986F59" modified="2009-02-10" version="1">MNERMTSFVTTASSLTSQDWTHLSLGDDPSTMATPDFDIIVQRVTSLFVVRMVALVAPLGTFADDISVSSVCRSLLLKPELWPAAVSETVVEQLQKFMHSILHGYKDVPYHNVEHACHVILSVNKLTDMLVSTEHHASLMKVPPTYGLRHDPLALFALLFAALVHDVEHQGIPNRQLASEDDRLAVLYNDQSIAENWSLYVAFSEFLQDEYATLRLVLFGNTSGPTNTAVKAQDNYAETYSRFRKIVINLVLMTDIASPERTQIGKSKWKEAFGEPFETVERKVRAQVRRMSLTGQNIEIRRNNGGSGTGVAASPSFDQRTKRRGTGDMSEIGMTDPVLQAKPSDIQGHDDDDDSLSVTPENSFHDEDDPQTFTSATQQLYPQMHRSSSLPARQKFERRLTAASSRTSPSTARYRQQRLGILRTVDLSGETLETYSTHARRNSTTNSTATHSEDGTTTSIDVDADEPNDLKASVVLEVIMTAADVAHNLQGWEQMVKWSNRLYLELRKAFVNQRGSDPQHRWFENQIGFLECYLLPLARKLEDTGMFSEGPQFSQIVETNRDRWLTEGYDVAQKTIQEGETKYPAIADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4B1</accession>
    <name>B7S4B1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fucokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_bd1431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176423.1">
        <property type="nucleotide sequence ID" value="XM_002176387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4B1"/>
    <dbReference type="STRING" id="556484.B7S4B1"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1431"/>
    <dbReference type="GeneID" id="7204897"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1431"/>
    <dbReference type="eggNOG" id="KOG4644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006983_1_1_1"/>
    <dbReference type="InParanoid" id="B7S4B1"/>
    <dbReference type="OMA" id="SRCPTQI"/>
    <dbReference type="OrthoDB" id="271303at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="4">
        <location>
            <begin position="86"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC42659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119673" checksum="3FA8461A2F7AEA48" modified="2009-02-10" version="1">MTAEATFFPFDRVVLTFPDQRAADAAASSTLPQFVRESYRNVTLVTACDPLGTRVGSGGGTLNALDVVFSASRDSDAHTNLVDDEACSILVIHAGGESSRCPTQMILGKAWTSLPTMSSVGSPGVATCRLQTPVHVWLRICERLFRGIPNGSIVVLAADTLLRLPDSKFAIDWEAHADTVFGLAVPAPLATASNHGVFVLPPMRTNAVPGASDQSSEPVIQVEPCHDVLQKPSQSTLQAHCQFKQNGQACAWIDTGVIVFLPTTATILRRLAFDDELLSRCTASTLQSMQNRHLADGDSPESALIKAQDASFRFDLYTDLLQALPMVASMDDRLDNGKVTQGPSYAVLRESFRSCRLSVMTIPSGRFLHLGTTRELLDFYTHGCHSNTEPLTASMSPPQALCREFGTSLALTRRLEAFTLVGPYGQIDPSAIIMHSSIQDSLSMESVGSLPMVIPDNTIVQQVRRVPQDEADTCACTLVVLGVDDKIKSLDGLYGRPLQDFMSWAGLSESDLWDEEADHKMVWNARLHPSIKPGDSYADLFSWLQLFLDEEPFSESAMRLWKQQHRYSLAEIRNKADAKGEFEFRRALVEETIPQQRACFLDQVQQTLHGRKHDCLDFQFAVDSFQIARNSYELEVVFQGLDTVLRDSLRERHFDIVARTANTFSTLLSNLIISNDTPVDNELLGLLLDFEVHVAREDNVKATQIVDELLKKRDDILKHNSVCGGYTMVMDRIAQIMTQACVCHRRYLENVLLQPRQPPIFDRWATATAPARVDLAGGWSDTPPICVENGGSVTGIAVVVNGQLPLSCQARVVRGGQGILLMAESRDTSNVLLSTVQCEAQTIADLQSYQDPTSDCALLKCHVVGIRFETTTLVDAVLVLEQRLTTGGGFQDQVNGLFGGAKQVTCPPAIPLALSVQPIPLSDAMRVKLNQRLILVFTGKTRLAKNILQTVLRRWALRTPEIYSNSQALVETSNQAREALQSEDEVALGRCLSEYWEQKKIMAGPDSGVEPLVVDEILRILRSKHAIDGGSLCGAGGGGFLILLAAHGWDKHGLEALLQDADQPGVTFNDLQWYDCHICENGIQTTVSDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0A6</accession>
    <name>PSBJ_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem II reaction center protein J</fullName>
            <shortName evidence="1">PSII-J</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psbJ</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Psb30/Ycf12, at least 3 peripheral proteins of the oxygen-evolving complex and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PsbJ family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874372.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0A6"/>
    <dbReference type="SMR" id="A0T0A6"/>
    <dbReference type="STRING" id="556484.A0T0A6"/>
    <dbReference type="GeneID" id="4524575"/>
    <dbReference type="InParanoid" id="A0T0A6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01305">
        <property type="entry name" value="PSII_PsbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002682">
        <property type="entry name" value="PSII_PsbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037267">
        <property type="entry name" value="PSII_PsbJ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002722">
        <property type="entry name" value="PRK02565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34812">
        <property type="entry name" value="PHOTOSYSTEM II REACTION CENTER PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34812:SF3">
        <property type="entry name" value="PHOTOSYSTEM II REACTION CENTER PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01788">
        <property type="entry name" value="PsbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161021">
        <property type="entry name" value="Photosystem II reaction center protein J, PsbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0604">Photosystem II</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-0674">Reaction center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000276122" description="Photosystem II reaction center protein J">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01305"/>
        </source>
    </evidence>
    <sequence length="39" mass="3999" checksum="F392A2A411227D38" modified="2007-01-09" version="1">MANTGRIPLWLVGLVGGLAVITMLGLFIYGSYSGLGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3H9</accession>
    <name>B5Y3H9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_46698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002185806.1"/>
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    <dbReference type="GeneID" id="7204612"/>
    <dbReference type="KEGG" id="pti:PHATR_46698"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="B5Y3H9"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_PARP"/>
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        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
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        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="464" mass="51720" checksum="2C8138DBD5328528" modified="2008-11-25" version="1">MSESKYTVEYAKSGRSTCKKCKVKIEKGQMRIGVHIDNGQFEYVNWTHPACFTMPRKLNMGANAMTTQQFIEAHLEDTTGGEILPAKAEELATEIDKKVDLQKKGDDNHSGSPLDSIKQEYEQQQKDTDSGNEPLPKRTKSSSGKAVELYAKYKSLKVDELKDFLRWNRQVMTGTKDIVLFKAIDGNIYGRLARCVLCGGRLKMNSDCTKVICSGSFDEDTSMRIDCAYQVEVPEAPRWQPWYTEEPSEEEQEAMDKLESEASLDIPAPDPELDVDIGKLVKEAEKLEWKLTSKDGLRKAVAELTDVVQKHEGKSVDLPDDIGSAKMKVGEVIARNREKSAAELVPIIVQEFGFKESKVAKAAKKEAAMEIMVKEPKNLPLVAAFQELSELYFKEGNRNAGASYAKVVSALKELSYEVTEENAKGLGKGKTKVANIGKTSADRIFEFVCTGKMEKLIEKRADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4I7</accession>
    <name>B5Y4I7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186300.1">
        <property type="nucleotide sequence ID" value="XM_002186264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4I7"/>
    <dbReference type="PaxDb" id="2850-Phatr43847"/>
    <dbReference type="GeneID" id="7203971"/>
    <dbReference type="KEGG" id="pti:PHATR_43847"/>
    <dbReference type="HOGENOM" id="CLU_363109_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4I7"/>
    <dbReference type="OrthoDB" id="49664at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="770" mass="85131" checksum="538C2E209485BD60" modified="2008-11-25" version="1">MAAPANANETLSIPEMPLSPHKIRDTTIEHSEKEKMFSLSVLRQSANLPTRPDCSSTDSMSRRKKLVFESPRLEQDDGDIFPSSQGTATQWHNADERYRYISQQAGTQIQNDVWQVPPRLLQHSDPQVLQRGMPQHVASRIRTLYLCAPNSAIPNDSLLTWLDTVQTVFVNLDHLHVGQATDAAIKEDSGMLNVDATNLDNEERMRRSTLTTKQRSQLRRLYILCHMPCLKSIDGVSVTFTERVLSRPAGAPRSELSIKSLETSNELNLNMSLFDGQDELDEEQDTPFLKEQGIEASLSGVKSQVGCSPTSLGLNFKKNVLDNLDRESLRDRMEYASLSTNVVACEWSAACGTLSLLRRFNVATADSKKKSKLKLAFRNHSSKTSGTGPTTDSEERSQDPTAGADTPFIKQLSTSSCPELVATDSEAKGSLMPHLLTGNISGKIHLRPRDRSFSAELPQRTSTDDPDNTIKLGRPVQVAVFETMTTSPNPSPPMLAGHNTQASPRCLESSSKVESLSPIKPTLSLLEKGMQNCNSQLNGGQIAIVDLPHHDATPHRSFEASTEMHLSMHLNATMNIEVKKVNASSPTRQTKSSNVTTCSLPKAPTSPNPESFRVFRKTSPSLSKQSAASTNDIELELEQYKQSVLPPPPPPPKRQVSPHNMETIESAITLTRVQSLPLALDRRKMPPNRGDLPPPCPGKRRILVAPSQTGRSLRRKEPRQVRLDARTTSIIVESDEEDDSSDEEVDDSSEDEEGRPATQNVTRRRAVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4W7</accession>
    <name>B5Y4W7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_7736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186080.1">
        <property type="nucleotide sequence ID" value="XM_002186044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4W7"/>
    <dbReference type="STRING" id="556484.B5Y4W7"/>
    <dbReference type="PaxDb" id="2850-Phatr7736"/>
    <dbReference type="GeneID" id="7204181"/>
    <dbReference type="KEGG" id="pti:PHATR_7736"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053603_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4W7"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14134" checksum="E9A381F1CFAA9F19" modified="2008-11-25" version="1" fragment="single">MGDRKVTNKYIPADFDPKLIPRGKKLSAKDGTVPVRMMLPFSIQCSTCNTFMYRGRKFNSKKEPVGGSEGRYLGIQRWRFYIKCTHCSRPVTFLTDPKNADYEMESGASRNYEVYKDKEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4X5</accession>
    <name>B5Y4X5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATR_33304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186372.1">
        <property type="nucleotide sequence ID" value="XM_002186336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4X5"/>
    <dbReference type="FunCoup" id="B5Y4X5">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y4X5"/>
    <dbReference type="PaxDb" id="2850-Phatr33304"/>
    <dbReference type="GeneID" id="7204384"/>
    <dbReference type="KEGG" id="pti:PHATR_33304"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_2_1"/>
    <dbReference type="InParanoid" id="B5Y4X5"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACI65842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="122" mass="13547" checksum="2F9BAB9C6BC5CF20" modified="2008-11-25" version="1">MADNHENGESTSEHATDLKSGPFSILYQAVRGNTQVLINVRNNHKLLARVKAYDRHMNLLLEDVKEMWTEVSKGGKGRTRGTAVNKDRYVSKMFLRGDSVILVVSNPAALAQPPQTTQPSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y5V7</accession>
    <name>B5Y5V7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_44249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186255.1">
        <property type="nucleotide sequence ID" value="XM_002186219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5V7"/>
    <dbReference type="PaxDb" id="2850-Phatr44249"/>
    <dbReference type="GeneID" id="7204148"/>
    <dbReference type="KEGG" id="pti:PHATR_44249"/>
    <dbReference type="eggNOG" id="ENOG502SW77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1889837_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y5V7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14270" checksum="787A4FD08A598589" modified="2008-11-25" version="1">MNGDGSDNGAPDFEALKKSVKNGIRKAVEATNRLLASLETTTDSVSKPLAKGVKKVEQEGSYLAGQVMRVYERRYEYGPHLVAGSALAVGGLMTLRRGKILGAASAALSGGLAYVAVYEPIPLQDMPDLIFGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNX1</accession>
    <name>B7FNX1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_9123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176610.1">
        <property type="nucleotide sequence ID" value="XM_002176574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNX1"/>
    <dbReference type="STRING" id="556484.B7FNX1"/>
    <dbReference type="PaxDb" id="2850-Phatr9123"/>
    <dbReference type="GeneID" id="7196290"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9123"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340534_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNX1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="52" mass="5617" checksum="33B350B657F0E7E9" modified="2009-02-10" version="1" fragment="single">MSANPTCADCGMENPDWVSLNLGVMICIECSAVHRSLGVHVSKVRSLRLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP53</accession>
    <name>B7FP53_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176649.1">
        <property type="nucleotide sequence ID" value="XM_002176613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP53"/>
    <dbReference type="PaxDb" id="2850-Phatr42676"/>
    <dbReference type="GeneID" id="7196329"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42676"/>
    <dbReference type="HOGENOM" id="CLU_1167817_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP53"/>
    <dbReference type="OrthoDB" id="49080at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855134" evidence="2">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="215" mass="24452" checksum="DF341A2A78F22400" modified="2009-02-10" version="1">MAPFLGMLLALPLILPSNAFVFRTPYIDFKRTQLYLLDPVSAGIGMDGAAGIGIGVEEAINVGIAVASAFVGTASQLPRIRALEQELKIARDSLDLMEHQMNTRISELEDKLFEIDREFENQTDRFKRSYDKQQLEDLERITKKMKVDFQYKLEIKLEEEKSKLLTKQLDLVNGVTGKRQAELAELRLRQIAMEHENSTLQKAQQKADEELVAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP72</accession>
    <name>B7FP72_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_53969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176657.1">
        <property type="nucleotide sequence ID" value="XM_002176621.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B7FP72">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FP72"/>
    <dbReference type="PaxDb" id="2850-Phatr53969"/>
    <dbReference type="GeneID" id="7196100"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_53969"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_3_1"/>
    <dbReference type="InParanoid" id="B7FP72"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="1285"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC51120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1423" mass="157042" checksum="BE4D0C5A8A4603D5" modified="2009-02-10" version="1">MAPSIPKAAATAAVTNGSRGAKNLKQGNLFSFFTTSRKSSATTKPSSPSVPLESTNAPVPGDTKPSTDATTHSPKSTTKRPLTPPLRVGDVLQVYWPDDKAYYQGTLVQIRRATSAPLHCIDYGDGQAPEWIDLNTTQYQRVSNDNQQQNIDNNNNRNQHKRRRIPEPDEPDEEAEFEFSGDLEEPESCADEDDESAYEQDEQNDNDDENEDQWMVTDDEDEAPRKPKRHSVSSRRPSLSKSRPTPSVTVTAHPPAAPHQTPARPDVSTTPSGPKRNPPHVTPSLAGASLATNTQPYPSPSLAATPSPTHATQTKGKPPMFEKGVVNIAGSHAHNHLPFLQNPRDAQGRTPDHPDYDRRTLKVNSRDWLNVTGGNMTDAVQQWWDLKARYADTVLLFKTGKFYEMFHADADVGVQVCGLLYMKGHVAHAGFPEISYGPMADQLVRAGYKVARVEQTETPDALAVRKKAHHRRNGPAPKVVNREVCSILTLGTRTFGYLDDDTHIATGQGGVGPLLAIRETLVDQGERQDDVEVEVQQAPVCEYGITLVDAVHGVVTIGQFADDVRRSRMDTLLTNFAPSEILVEGGPNGASDTLLSLIRTAQKTSLQSTRLEIIRATEQFPQSTALDPEIRRKLDRPLSQIHPWDVSETLDELHRRRYYPRASKQQTDHVSVSRWPAVLRAAVEGGATLALSSFGAVLFYLQRNLVDGELLSMGVVKAYIPPSSSTVTEESPSRIQTMAERDSWSEAGVDIDDQRTTAPLSTKTSPNVTQATQDPVPMQFEMVEAINIENDINHMALDGTTLHNLEILYNSVDHKANGSLWSKINLTKTPHGSRLLRAWLLRPLFRRADIDRRADAVQELVSGGAGMALSEARSVLAKCGDIERLLSRVHSMSGMTRIPGEEDDADDGSSYYPSDRAVLYETSTYTKRKVGDFSKVLKGLQHATQIPELFDGIEIQSGLLSKIVRFTDQGGCFPNMIQELEWFFENFDLDQAAKGFFEPSRGIDDLYDQACDAIAHIQSELNDYKEEMCSTYLQPRSAARSSWKYINTKPESKEKYTIELPASVRVPDNFILKGKRGSGTKQMNRYRTAQLEHFVQEFENAYEVQKKRKARGMQLIFAKFDSMRSLWAAAAQATSLLDAIGALAQTASKPGYTRAKILDCPQHASPTIRVTGGRHPCIESSIGSNDFIPNDLSLGTETSQDNASRVLLLSGPNMGGKSTLLRQTCLISILAQIGCFVPAEDCALTPIDRIYTRLGATDRILLGQSTFFVELAETAAALRGATRRSLVIMDELGRGTSTFDGTAIASSVVKHLVDRSKCLSLFATHYHSLLEEWKHNRNVRLGHMECIVENGITTSRPENEEKDESTITFLYTLGEGVCPKSFGINVARLAGLPEDVLSNAKRISSEFEQEVNGNGSRATSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPA7</accession>
    <name>B7FPA7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_9011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176676.1">
        <property type="nucleotide sequence ID" value="XM_002176640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPA7"/>
    <dbReference type="STRING" id="556484.B7FPA7"/>
    <dbReference type="PaxDb" id="2850-Phatr9011"/>
    <dbReference type="GeneID" id="7196116"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9011"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="InParanoid" id="B7FPA7"/>
    <dbReference type="OMA" id="GCQFAIT"/>
    <dbReference type="OrthoDB" id="38580at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="194" mass="21074" checksum="8A6B46C55C770FCB" modified="2009-02-10" version="1" fragment="single">GATKTTEPAKPQSDITSRAFFDVSIGGKPAGRVVMGLHGNVVPQTVKNFETLCRGTETMGNLRLAYEGSTFHRIIPNFMIQAGDFTMHDGTGGRSIYGTEYDGRFADENFQLKHVGPGILSMANAGRNTNGSQFFITTKRTPHLDGRHVVFGTVVDGWDVVKKIEEFGSYSGKPSEKIVITKAGLIEDDGDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPB9</accession>
    <name>B7FPB9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_42728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176682.1">
        <property type="nucleotide sequence ID" value="XM_002176646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPB9"/>
    <dbReference type="SMR" id="B7FPB9"/>
    <dbReference type="STRING" id="556484.B7FPB9"/>
    <dbReference type="PaxDb" id="2850-Phatr8950"/>
    <dbReference type="GeneID" id="7196122"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42728"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008749_1_3_1"/>
    <dbReference type="InParanoid" id="B7FPB9"/>
    <dbReference type="OMA" id="VMENQQE"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000470">
        <property type="entry name" value="CbxX/CfqX_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00820">
        <property type="entry name" value="CBXXCFQX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852494" description="AAA+ ATPase domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="260"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC51145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="505" mass="54287" checksum="1699A5BC863D7975" modified="2009-02-10" version="1">MKFATAVTILSLATASAFVPTTISTSRATCLYSGVPGGWTPGSGGGGGWDDNSSSGGGTGWGAPAAPAPAPAAPSGWGAPPAPAPAPANGGWGAPMGGAAPADNGWGGGGMGAAAPAVAPPAPAPASNEGNANPFGTKSLDWGGNDNDPSSKTVRLRDRLNEVDTERRKNEEEAANRERAAEIRKEERQKKIDYMNNMPDSQPAGTVEEFMFKEGVQDQLDKLDRELVGLVPVKKRVKEIASLLVLDKMRRKLGFETAVPSLHMCFTGAPGTGKTTVAVRMGQILAKMGYSRKGHVVLATRDDLVGQYVGHTAPKTKEMIKKAMGGVLLVDEAYYLYNAANDRDYGQESIEILLNVMENQQEDLVVALAGYKDRMDKFFSYIPGMMSRIGNHIDFPNYSADELVQIASVMARELEYDIDDNAYPVFKAYIEKRMTLPFFSNARTVRNAMDRARMNSAIRTFERFAINGENGGICTVSDLKKIQADDFQVLLDDINNADVSKRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPD5</accession>
    <name>B7FPD5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_42743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176692.1">
        <property type="nucleotide sequence ID" value="XM_002176656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPD5"/>
    <dbReference type="STRING" id="556484.B7FPD5"/>
    <dbReference type="PaxDb" id="2850-Phatr42743"/>
    <dbReference type="GeneID" id="7196128"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42743"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518268_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPD5"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="13">
        <location>
            <begin position="387"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC51155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="669" mass="74474" checksum="B2968377A3652596" modified="2009-02-10" version="1">MKRIHGAHSRPGTKPLSMDTTLDDADVYTVSSNVDPAFSLSSSVPQTRTLDSTRSERIGRSRKQPSASMTQGRKPLSMDTTLDDADVYTVSSNVDPAFSLSSSVPQTRTLDSTRSERIGRSRKQPSTSMTQIKCKASFERQYDLTPLGLTTDAGASSRFSLDPWENDSESKKMVKEQTSTSNRSNQLQRKASDTSPSSDDTEEIHFVDESPSVMSTYLDPEEIHLSMEDREEEIAQLRLLAGKLSADWRAQDFVAPALARRMRDFHFAQEKRRKKYGDERPWGILGLYDHLSAIRIDVQWAEDAAWRRANGEPYLSWADFDESKKGGKNRPYFTYVLLFVCTANMIASIAANDWTVESLDENPMIGPSAATLIRMGAKDSYLIVHAGEGWRLLTSTILHAGLVHYFINMLALWFVGGAIEMSHGWISAMIIFSSSAIGGIILSAIFLPEFITVGASGGIFGFIGACLADIIMNWKLLFDGLLDENGKKHQHTMVVVVLLFDIALNSIIGLTPYVDNFTHLGGMAYGFLCGLSTIERLSKDFFGLEESWMVRAKNFCVRFFGIIVTVVFICVTAIILMGGDGVTTPCTNCSWLSCVPFPPWQSQSNKWWYCDDCGRITAEIISEPYLHLELDCPGGTIGFVNVTSDQLDRGKLEQSLPSYCRQYCPIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPP5</accession>
    <name>B7FPP5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_42826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176748.1">
        <property type="nucleotide sequence ID" value="XM_002176712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPP5"/>
    <dbReference type="STRING" id="556484.B7FPP5"/>
    <dbReference type="PaxDb" id="2850-Phatr42826"/>
    <dbReference type="GeneID" id="7196486"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42826"/>
    <dbReference type="eggNOG" id="ENOG502S0EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271748_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPP5"/>
    <dbReference type="OrthoDB" id="10047023at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="entry name" value="DNA primase, catalytic core, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="entry name" value="Zinc finger, CHC2-type domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNAG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050219">
        <property type="entry name" value="DnaG_primase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313:SF2">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="DNAG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13155">
        <property type="entry name" value="Toprim_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="Zn_ribbon_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855255" description="Toprim domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="406"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1192" mass="132474" checksum="3AD6A19E98102CF1" modified="2009-02-10" version="1">MQVFFFLLLELSSVAGFTGLWSRSSGWRNQAHTSYSSWLRVVALSPDADGTTDQDDFSLLRNATNNKAPVRSNEIGNGRIDFNQLSEMKESIDIISVIESYNLDRFERKSDDRATALCPFHDDENPSLSIDRTRKMYKCFSCGAGGDAFRFVREYSKLKGQQMSFYEAVLEVSTKFGDGHVEGIGKSVQAESPELRQRKERTLYANAVAAAFYATCLTKPSAGGARQYLRQRGLTPEAVRTFALGFAPDFYYGANRSRKKWGEDSLVQHMQSLNFTVDELLEAGLATETKTTEEPVQKFSFGEDPLLEGAFTSKPTSTSCPFDSIIDRFRFRIVVPIMDKAGANVLGFGGRILPSIVEMPNAYNPPKYLNSPESLVFKKKCILFGHSLAKETVKQPKKSEHEQLANTLILVEGYMDVMSLWTIGVRNVVAAMGTAVTMDQLAIAAKSIRNGNLVLCLDNDSAGLLALERLCSNGLLSRIVSKYGTEISIALLPSGIKDPGEFIESKAEAASTTIADAFQTEVLSKSQDWIDWYLQQLLESYDSKAGRGRAGSFGDVFERVANFLANNMGPADRTKHACEIAVSLAKTTANEMGSDHASSAVQNQLESDLIDLSSRLAEKKRAIQRRTELVNSDGNVGSQKDALFALTRGSGPSADESDKLSSSASKGSDLLSVALNDVDLLDKFPAPSFERASLTRRKRTHDAAISRTLNKALTPHFSGFRFMYKSDSQWLGVDEDKLKGGELTLGYIKNTWRKKEKSIYFNSNDYHGHQFLTEDAMDAGYVNRNVRRDPSFVEKGVACLVYRDTELMLKTAEDNMLTTLVDCPSARTVLKNMLDARSATGSSNLVEWTNTEKEWLFSTLVYSSSSIPEGCTNRTELMRFLKRIPDCPPQAFIHTTVSANRNSNSKKDYTKSLPESSNEVIGGKEIYGRFDTYSKVGNGTLSLFFNGVRNDLDSAASLNVTRVNVLTQERWAAVLWASTAHQARQIREKLLSLSNAMEGRTATGIKNVRFAVSPEVTLSSDHPVEGDGNPCDSTRLRDLTIALQNKNRVLQTLSDSSKRLWTKLVDETLSDGIEGHVSASLQMDLSVRLDEYLNAFIDVPSQKVETTQKLETILSGLEDEEPYEDTLERIAKDWGEWADDDYLWTMDDAISKTNKKQVASPDLISAITEDEDDENVEDALQRISRDWAEWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPR0</accession>
    <name>B7FPR0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_41686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176755.1">
        <property type="nucleotide sequence ID" value="XM_002176719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPR0"/>
    <dbReference type="STRING" id="556484.B7FPR0"/>
    <dbReference type="PaxDb" id="2850-Phatr41686"/>
    <dbReference type="GeneID" id="7196494"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41686"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="B7FPR0"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="430" mass="47602" checksum="59A36F921CF14E6B" modified="2009-02-10" version="1">MLTWAPGKARHNTPIITHGEGVYLYDDKGTKFLDWTSQAVCSNIGYDLPEAVIEATTKQMSTLPFVYGGLGISEVRARLSKLMTELLPGDLQGMVFPSCGSEANEAAIMMARRYTGKYKVINWYRSYHGGTSNSQQATGDFRRWFGGDHVPGFVKAFHPFPLFWDLAGATEEERTQHALNMLEEQILNEGPDSIAMVQFESVIGGGGVLVPPKGYMQGVRAMCDKYDILMHCDEVMVGFGRTGELFGFQNYEGVIPDIVTAAKGVTSAALPLSMTACRKHIMEAFEEKPLGWGSTYASHPVAMACAYENIKYLIKNDVIGHVQRLAPTLESEMRRLTENHPSIKQYRSIGMFGCFDAHLPDGSNPQLQHTAIDKAFVEYKKAYTANGLIGLLRPPHMHVAPPLVISEEELLDGFDRQDKALYALDDALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FPT8</accession>
    <name>B7FPT8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_42861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177272.1">
        <property type="nucleotide sequence ID" value="XM_002177236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FPT8"/>
    <dbReference type="PaxDb" id="2850-Phatr42861"/>
    <dbReference type="GeneID" id="7196448"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42861"/>
    <dbReference type="eggNOG" id="ENOG502RRBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485288_0_0_1"/>
    <dbReference type="InParanoid" id="B7FPT8"/>
    <dbReference type="OMA" id="RTNICCE"/>
    <dbReference type="OrthoDB" id="41213at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36796">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36796:SF1">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854859" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="562" mass="61536" checksum="FACA23939F51AF5E" modified="2009-02-10" version="1">MKPLTLVLWAARSATVVAFVVPKTASSVFLTPHRDATTTTTRDTPDPGTRLDAEKIPWTSDFDDFPSDNSSGNNNQDDDDALETSFRTLFASKQDKDRTAIQSRQLSLGKDLVLENFVGTLGFDEVTDWEYYYPEEDGDDRRVVQPNPFDSSQPKRTRTSSGSVVRIFRGELVGPLGALVSAQGNDKRVLVKEYTGTLALALAQAELECVAQLQSKLVDENWSKEASARSVASRLDNGRLASLVPKLKRGKFLGILGEVNLAELEDDWDPNEFYRALGVQPPKPDAIWVVSEYAGLASLQAYTSQTPQQRWASLPPAKGLFGNLIPPAPLPSWEARAKYIVNGIFQQAVMAIADLHEAGFVHRSIGRSSLLLASTTNNPQDASSVYTTTPSTLTVKLTDFGFAGPYETAAMDEEFVSRARTFGLHFRKGETSIATTNFALAEDFHALGFVGLALMLSCLAETSTSNTSAATTQSVPATDEDSLQRLLGEIFDKDVKGQFRDYVAAEDCWAKVVDLLDAQDGAGWTVLETLVLAREKAASQSTKDFDQIFNIRGLLSNPFFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ45</accession>
    <name>B7FQ45_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_42950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177330.1">
        <property type="nucleotide sequence ID" value="XM_002177294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ45"/>
    <dbReference type="PaxDb" id="2850-Phatr42950"/>
    <dbReference type="GeneID" id="7196195"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42950"/>
    <dbReference type="HOGENOM" id="CLU_948209_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ45"/>
    <dbReference type="OrthoDB" id="43376at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32303" checksum="CA00A7474D784E0E" modified="2009-02-10" version="1">MAIPEAKQQAEPKTHPLPVRSVTVLMPLVETAQAWFQRSCRKRALAGIPKDSSSAAWAFFRSGGTGIAFLDTLLRRQGGSDQLPIIDIRGDFGKTWTVVSLAARFVVATRPSQFPTAVGDHSSLPQVIVMDTTHDVTTSKVALSVRSTLLRQFGSAVEDSFEMDMISCLGRIHVATADDAFGWVPILETLRYKLAPLSAEGPTLILWDGFLSDAEHDEANRMEIIRQLGRLVEDCSVVLVTASTGYRHKHEWNKYVTHHIRLDRNESNGTGHEFLATIHGSQIPFSLSAAGILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQW5</accession>
    <name>B7FQW5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176939.1">
        <property type="nucleotide sequence ID" value="XM_002176903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQW5"/>
    <dbReference type="PaxDb" id="2850-Phatr32339"/>
    <dbReference type="GeneID" id="7196925"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32339"/>
    <dbReference type="eggNOG" id="ENOG502SC27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FQW5"/>
    <dbReference type="OrthoDB" id="2402896at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="666" mass="75664" checksum="2B7B734EDE311BDD" modified="2009-02-10" version="1">MEPHEVKKSIAYINGHEVQITLDAAKSSAPPSVIGKMLHLQTGNILSDSSLQHIRIQSGKEQETVLLKDEEFMTQADKLLSYLENTPEISFCAIYDDPDSPLFTVYKQRAKKDRRCLPTSIRVNSGVSAETGILDNATLDAMDPNGELDDYVDRTRRAFKLLGSQKMLLGVAWTNNESRNVFSRFSEIMVADVTEGTNNAKRPLFLFSGKTRLVGPSIGCGLDAYRNYSQNGDPKEYGTFVDAIPTFYPLCEHKLCHWHLLYRSNLMKVQTGKCGVKATILFRVVVLWIESWMTKIETQEEYELSKRLLADWLATPEAIDVKLGGMGQTIVSQINAYMTLSLFPHEQRWARYRYLYTRAFNTSASSYAEAENSALKRRGDGVRPSFSVPKATQVINEGTQIRSKKRHQKAVYNLNAAKTRKPAYYANIGDLVDYIQDSLSKDFEAAASFVLFRPNADQFWVKQATRKSKNTDIRKINDSSYYKYMIPQFERTRIVELVNIDGTFYLVCSCGKFQRQASPCAHLYKVLGQSPTSTDVSVRWTKHWDVYLHRSGHSDLSKHLEDLYKQERPGPVFVDSGQWVIGKGSDNGKCIFYKKNVWLKCFCAQFHFYQEMSKLAGFDMEAAESMNKAMQEALEKVQANVAKRAGKMDYTIGPAITKDHAFFNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR22</accession>
    <name>B7FR22_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176970.1">
        <property type="nucleotide sequence ID" value="XM_002176934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR22"/>
    <dbReference type="STRING" id="556484.B7FR22"/>
    <dbReference type="PaxDb" id="2850-Phatr43228"/>
    <dbReference type="GeneID" id="7196951"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43228"/>
    <dbReference type="eggNOG" id="ENOG502RWF4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418886_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR22"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="655" mass="70908" checksum="64DA5899F1704456" modified="2009-02-10" version="1">MRPSSFLTASVESAMRDTLADLQIRSQVQDVLTELVADVELTAHLQERVEHHLTIKSLQVRMAQHEQALAEASYVENQTREESMTMADQLVRELWSVSRELGALQDLRAQHKELLSQHDEVLANLMQTEEDLAEIRARGVRVVAERNEGSGMAETDGSELQQQPAASPTTLPKISVLEPQPLQLIQSEETASAAAPVISNTPDDASAPISNLKGQDFTDTKAVENVADESVLSGSNSQLLSETQAIDKKLPPVATPIPEPAATAVVELDVDDDNPPKLEELDTEILMNMFGFLDALDILNMAQTNITMYSRVDSLFGLGGSGAEAADDSSTIASTEITPTLKTTTVGSSDKGMHSSATMAVIPPIDTGSIGSAGPTARLSTTTDTTSSAPINYSAPSRPSLFGLFNQAAQRSIANATAGSVSASNSAPSPSRTTSLHRRNSSATDAAPMNAAMANSMASKLTDAELNAIILMTERLRQKELLAKQLTDEKEKLAAQLDGTESVKQFLVAKIRDMETAISATVENETKVAQQIASDQEVIAFLDGRVQDLERENTVLLKEKAATFEQLQKAQQNSTEKAAVMGDMLQFEREKLFENEREWKATKKLLVKEVKSCRNQIAALQAECDGVREQNEILRKTVLSASQSSPTMAKDRVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS81</accession>
    <name>B7FS81_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF885 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177935.1">
        <property type="nucleotide sequence ID" value="XM_002177899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS81"/>
    <dbReference type="PaxDb" id="2850-Phatr43434"/>
    <dbReference type="GeneID" id="7197440"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43434"/>
    <dbReference type="eggNOG" id="ENOG502QUES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_1_0_1"/>
    <dbReference type="InParanoid" id="B7FS81"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="67089" checksum="EB1E4A732F8BB088" modified="2009-02-10" version="1">MGLLSTRRSTHALDPRSLASFQQRLEWLRAALQRVHANVSRDDLRDEQEQLSYDIYVTQLSDYIRFTPWHKSYLCCLNRLEGPQTDLPLYARYLPTKTKEERAFYLKFLQAIPIQLGEVINLLQTGLVENRTPPKVSLDGVVPQVRGMINGNLEAFREPIRNAFPKDEAKILEACQAQIDGSVTQAFADFADFLQNEYIPHLREDISAVTGYPDGKQYYQDCLAFHTTTSMTPDEIHELGLSEVERVRQEMEAIAAQAGYGGRLDDYLEHLRTSKVYEAESGQALCSLFRDITGRIAPAMLKLFHLETLPRMPFSIVETPSAHASMAPAAYYLAGSTNQSASRPGIFYVNTSELPTRRTYECEALALHEAIPGHHTQGSIQGESHNLPAFRQMQEDRRYFEAPCRFPFYTGYIEGWGLHSETLGEELGLYTKPESKMGQLSMEALRSCRLVVDTGMHAMGWTLDEALHFMLENTAMGKHDAATEVARYVTWPGQATAYKVGERYLRKLRTMAETELAEKFDPRDFYDVVLQVGPVPLDTLEKLVRDYIQETSNRTASSGGDLSEGEPGFLEQMTFFNWCKCCVVPGSCQSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSA2</accession>
    <name>B7FSA2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177629.1">
        <property type="nucleotide sequence ID" value="XM_002177593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSA2"/>
    <dbReference type="STRING" id="556484.B7FSA2"/>
    <dbReference type="PaxDb" id="2850-Phatr32665"/>
    <dbReference type="GeneID" id="7197165"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32665"/>
    <dbReference type="eggNOG" id="ENOG502QT0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007585_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSA2"/>
    <dbReference type="OrthoDB" id="191535at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861">
        <property type="entry name" value="DUF2183 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861:SF1">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1149" mass="130532" checksum="3A96054789CC0CA4" modified="2009-02-10" version="1">MYLFMAYEESGVHHAQEFENRFWTIFALLLSTALFFARDSPLAFGLWSPTLGFIGVLISGYAMHLWDRYLHRLAISQQIRNLGMRRSTTANSSLMRLKDLGIPVEDQLARINTCLQDIDQLLIPSTINNFINQRFIFTKEQEIISVFEECDARALNYLVSHVKLGLLFYKIKDHRSFNGKHRTALVTLLAVERLPILTIVSRVIVLHSLQLLKLRANPKAEFWVRNILLNTHQDNLSELKTLTDTKGDYFCMNKLIYDDIRSETTRQDILNHIRREAAVQQTHIQMGTRRLTKYRMHGQFRKVLSDVDDTLYCSGGMYPAGVDKRYPKKAVYPGVLAFYRELDLGTQGPEEWQDEHVGNLVFLSARPHVYKDMSEKANFAKFEKLRAQGADGRKGMHTVPSLLAGDLASGTSYMVTNDFEPLAQKKFDNFRRYVSIYPEYQHVFVCDNGQGDVRAGELMFDSFPYEFQSLYVHVVMPIEKTHGYSPQRWRQKEFMPHFFRTYPEAALHAASRNPPLIRLGGLQRICRDAVKDFEQITNWSTEAMKAERRLELNQAVWRANSFLEWHYLDQVELIKAECRWTLGQRVRTPYGIGIILDFDPVFDLYGVELDWRPLDIQVIEHLKNPSSSIIRPKEIATSSGLGAKRSLSTVVEMESEEADDEATLQISVGLHLPKRQEVGEPSAERPITDRQRSDRSRISTRKALGTNVLSENGNVQQQRREVESSIPNDFQRLNQETKAKAISVKARIGGRFISKLTPPVLPKIDKEKGRSIFTFLAPVQGSVPLAFKEGDECTTPFGPARVAQYRSKNEIVVVDFIGWYAVGYLAQQDVKVIPKSLLRSLFRQMSASEGSQRPVDYSSSDGTVIATPFGLGSVVRPVAPPGRDTKRAVSPTVRIRLESWTLANGNHPELYCTVENAEEWKKSKSDETKSIFSALENLVTSSRTLFEPFLSNKTPTKIEPKFEQYYKDSASVTTIFGEGVVHRFRSIDGFYEVHLTRWMLASNKCATAFLRRESINYRIANGCKEGYPVLTTLGASGTLASVDPTTGVHIVTVPTAGMICYLQPDHIARSLKAAVGENVLTAFGEGKIETYSLQNDTYTIILAGWRGKLFAKEVSFERVGDGVQDRDGPFGFGKRPSKSKQQPHRWKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSA4</accession>
    <name>B7FSA4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_18132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177948.1">
        <property type="nucleotide sequence ID" value="XM_002177912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSA4"/>
    <dbReference type="FunCoup" id="B7FSA4">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSA4"/>
    <dbReference type="PaxDb" id="2850-Phatr18132"/>
    <dbReference type="GeneID" id="7197166"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18132"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597997_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSA4"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="160"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="377" mass="42536" checksum="A92AABDA8EDF9564" modified="2009-02-10" version="1">MRRHHANKRAISCIPIFGVGLVLSVLFAYTASLRAVVIQRWCDPEEISCHWIVIHDVLTIYFVTMIVFHYTATVLTSPGVVVSGTTPVRWNALDGQGGVWGYNLEVDAEAEAQRLAMYGTFLRPSDSAPTRGYCATTTANTAPIAASSTAAQIMIPDDLASFCATCKVWRPPRAHHCGCCKRCVLQFDHHCVWVNNCIGYHNYRSFVLLLAFLSIACGYGVALLWHEFYDPLRDQIRLHGWKWLYSNGTGLLDLPQPIQLTKMLLSGTVEAKVIVDLVLPLLFGVAVIMTTFFCFHLQYILTAHTTLEHRIYLEHALAQQYQIRQGASSTIRIVNPFDQGWQKNWQHTMGPNPWMLLFPRRFAPPPSVVPTRADHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSA6</accession>
    <name>B7FSA6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin remodeling-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_54092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177949.1">
        <property type="nucleotide sequence ID" value="XM_002177913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSA6"/>
    <dbReference type="STRING" id="556484.B7FSA6"/>
    <dbReference type="PaxDb" id="2850-Phatr54092"/>
    <dbReference type="GeneID" id="7197524"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54092"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407985_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSA6"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="4">
        <location>
            <begin position="355"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="674" mass="72191" checksum="68762099753589DA" modified="2009-02-10" version="1">MSEKNQANPKDNPVAMDVDGGDVGNRHPLTRIPADGMNPTNLLTGLYGARGERVRHLVHEGALRLPTEALDLIGPTDAATSSRKFQLPGLDSVVRMSADPKVTSMRVTEITGKLVPSTEPEQPPTFRTFATNKTVVTGSGPERLRGGGDDNDEEIKAPAPTAAPTEIAERTAATVTSSEPVATHSSVVATVDKAPSVGVPEQTSTAPSIPAETILDSQPVLSLSLETSAPSLKRDASLPVSSEISGTPAPVALEPIMATSLSVAPPTKADERILTKTEKSETVPPASVSAPDPVTKTSSATEVKPVQSTPEGRANKETSKSEETVPDVVALSKTPAPQWEQHIPGPSDEMQVDPASKTPKPDWYDAARASEIEKSVLVEWFDQSASHRTEESYVQAREGILKIAAGIGNRYVSATMVRRSVPGDAGSLLRLHAFLTSYAFINEDSMNDSAPTPVTLQQEVDKRHLWNDELKRALLDNVVEQSRKRPKLLSSDTNENGLVFDWNAVAAAIGNGMDATECERQFLSLPMDDLTSTTERPITPEPSLEGTPLSAKGNGELRAQVLQDIVDNSDPDVLRAATQAVFAATEDPTANLAALQNTTVASLLAGQALAQCRKEEANVANLLAGVVDLRMQKLENRLTLLDDLEGLLEAERVALELERRDLYTARCRHWFGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSG6</accession>
    <name>B7FSG6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177660.1">
        <property type="nucleotide sequence ID" value="XM_002177624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSG6"/>
    <dbReference type="PaxDb" id="2850-Phatr43508"/>
    <dbReference type="GeneID" id="7197553"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43508"/>
    <dbReference type="HOGENOM" id="CLU_701079_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSG6"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="143"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="44052" checksum="4A0E0E8028E6DF41" modified="2009-02-10" version="1">MIRQHLPTGTTSLPRTGGLSVEPPRYRHSMAADEEDRAVGPLRDVDVVNLSQTSQAEQHLKDAVDLLPSEESASYRKALLRCNDVVATETNPNLFLESEGFDAWAAAKRLAKYWTCREQYFGSNRAFLPLLNLALPPKQRALSCADIAQLQLGALAKLPTDKYGRTVLLVDRSRLDGTRSDADSDRWLRVIFYWLSKVMHQKNVQKNGFVVLKIMRGQNLDRQRLLQTQVMVRDCMPCRVTGLHLCCVPPPGGRKTFADTIAPILWQYIVHVLRRKANVHVAESETHMLTLLQDYGLLKESLPKSLGGSWSYAKFDTLVNKLLCGNADRRNTEGDSSGIDFGSLKPSAMRSGAGHSNPLSPSIRIQNRKSLKRKIDAVFAGVPARQQHKKRMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSK1</accession>
    <name>B7FSK1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">helicase_4</name>
        <name evidence="11" type="ORF">PHATRDRAFT_18199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177678.1">
        <property type="nucleotide sequence ID" value="XM_002177642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSK1"/>
    <dbReference type="STRING" id="556484.B7FSK1"/>
    <dbReference type="PaxDb" id="2850-Phatr18199"/>
    <dbReference type="GeneID" id="7197215"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_18199"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="InParanoid" id="B7FSK1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="187"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="595" mass="65121" checksum="EBE0CDECB5889E4B" modified="2009-02-10" version="1">MAGRDVIGIAKTGSGKTLAYVLPLLRHMDAQPDLGPHESGPLGLILAPARELAYQIHVVCKNMAKPLGYKSTAVYGGAGVAEQIADLKRGTHIVTATPGRLIDILTMQSGKILSLQRVTYVVMDEADRMYDMGFAPQISAILAAVRPDRQTVLFSATFPKAVESLARKSLQYPVEVMVGGRSVASDSVTQYAERVEEDEKFLRLLQVLGEQVEGTKKVIVFVDTQVRADNLFEQLLRNGYSTLSLHGGKEQEDRDSTISDFKRKDGPNVLVATGVAGRGLDVGSCTCVINFSAPNHLEAYVHQVGRTGRAGNRGVAYTFVSSTDEAKFAPNVVRAMSEAGQGDNISPELRQLSDEFQAKVEKGEARYAGSGFKGKGYTYDSTELSEAQKMARLEKRQALLEAGLLDPDEEDPYANDTNDSHLKNDSASSSTQMKKVAGIEMEIPDTLTPEILALPGMKEALLRKAGIILPTAGNEGEAATEPLLGPVRMGDNHWLREFEINEYPREARWKVTQKDTTSRLQEEFRTAVTLKGTYFGPGKEPKDDERKLYLHLEATSDRMLQDCVQEIQRLLNEETLRVSAKQGVGGGSHKYNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT93</accession>
    <name>B7FT93_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_43728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178115.1">
        <property type="nucleotide sequence ID" value="XM_002178079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT93"/>
    <dbReference type="STRING" id="556484.B7FT93"/>
    <dbReference type="PaxDb" id="2850-Phatr51560"/>
    <dbReference type="GeneID" id="7197018"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43728"/>
    <dbReference type="eggNOG" id="ENOG502QS5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_1_1"/>
    <dbReference type="InParanoid" id="B7FT93"/>
    <dbReference type="OMA" id="DQGSMCM"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF4">
        <property type="entry name" value="17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC50929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="35628" checksum="FCB957DBF0837E9B" modified="2009-02-10" version="1">MSTSDAGIGTCEASHGSMPPLTILAMIFAFPTVFWFVAYLIPQLYMVVRPVPDLKKRYNAEWALVTGGGSGIGKALAFKLASQGLNIVIVSLDDNFLKSTMRELAEMYPKQSFRAAGVTFSPGVDYMAKINAATKDIDVPIVFNNAGFMVTGFLDQTPIGKLLANIECNATASVNISHFFVQKLVAKKAKGCIVFTSSVAGFIPTPFAAMYASTKAFVSQFAACLHIEVQSLGIDVCAIHPSPVKSQFYTNLDHKVDMIEKAATSAVSPDEKLADTMLKSIGVCALRDMGGLAWGTRMGTFFLPYNFFAVAFANAAPFMPDWKTHNKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU51</accession>
    <name>B7FU51_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 3 subunit K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_33885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178537.1">
        <property type="nucleotide sequence ID" value="XM_002178501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU51"/>
    <dbReference type="SMR" id="B7FU51"/>
    <dbReference type="PaxDb" id="2850-Phatr33885"/>
    <dbReference type="GeneID" id="7197686"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33885"/>
    <dbReference type="eggNOG" id="ENOG502SC3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595127_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU51"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50562" checksum="FF9F37F0CC79A65C" modified="2009-02-10" version="1">MISSVALKALRGLATPREKTGYCATGLFSSLNKAFAPSLNSELNDARSMVTQRRCKHSSTQLKRKFFQNPARARVEARRGVDRTPEPVGPRMYEAVFAFTMLPNGWSAPPGPDVQLPEYPFQMKRTKNKPSNAIGFLPVYSKFRKDGTKTTTLIKKVKGDREAFIRELRAVLDLPVPVLAREDALRIRVGGTIEVDGNHQTGTPCNNVLLLLPHHGTGLQESERFVWTSHSTSKKRLLLEMAPTLAEIKTLVASGPKSTSLPQLEAYLDAQTSGSVPYEADAVRYLVKTYQLFPGTMNESKVAYACMLALLEGYPSTDILALSYMIPIAVQKTEPCATVLECASQLEACQFVAFWKTYEKLKSSEDPVIAVFAKNSIVKLQGAILDVLALSYKDAPTQVVLSALNASSPALVTALEHSSVEYVNDSTVSFQATVDNTKRQRVYQEGVTYAAITSLMNQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU81</accession>
    <name>B7FU81_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_33916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178273.1">
        <property type="nucleotide sequence ID" value="XM_002178237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU81"/>
    <dbReference type="PaxDb" id="2850-Phatr33916"/>
    <dbReference type="GeneID" id="7197701"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33916"/>
    <dbReference type="eggNOG" id="ENOG502SR2D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872808_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU81"/>
    <dbReference type="OrthoDB" id="43967at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="319" mass="34387" checksum="0DF26716C4E423E3" modified="2009-02-10" version="1">MAKASSLKRGVSSQRGLLASLWSLVTVMTVLAFIVALIFTFAGVQEGDSYSNRNQNTNDQDASDPKVAVTSRGMAVAALWTAVLATLISIFGTVILGWQSPTGRYYSCCSTKVHQTNALSLGSFIGTVFMFANLTFICAILFGEFEIRDRCGEGEGRKRDGVATASAVARSSTAFSIACLFLTLLYGGFVSILFVYSESILEELTAVEKEDLHNARCIHSASPTPFATAYTGYIGERFDVRRNLGSSAAGLLLMTPKPANCLSDGTPFLAAQFVAALDSLNLNPLSTTLYLNPSWSVTYNHLSVPGYSQRNDFHKEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU93</accession>
    <name>B7FU93_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_44478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178281.1">
        <property type="nucleotide sequence ID" value="XM_002178245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU93"/>
    <dbReference type="FunCoup" id="B7FU93">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FU93"/>
    <dbReference type="PaxDb" id="2850-Phatr44478"/>
    <dbReference type="GeneID" id="7197709"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44478"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011488_2_0_1"/>
    <dbReference type="InParanoid" id="B7FU93"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001717">
        <property type="entry name" value="ATPase family AAA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF12">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="330"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="549" mass="61329" checksum="BD65516896AEDF0B" modified="2009-02-10" version="1">MFGGGGRKKKDESLSQAMKPENPPSGGGSVTGFDPEGLERAAKAARDLDNSRNASAAIELIKTQEATKQHEAAAKRAEMDAYAQQLRAQSIEKEADEARKTLDAQTQHEQRRAEYQDQLERKRQVDMLNAQKYMQEEQLKKQEEMVARQEEMRRKTAQYEAELRTKTEIAKAKAEAEGRIAQERQNHDLILDKVRLEASESRDTVLKAIQDGGKLLGEGLSSYLNDTEKLRNTALTITGIAVGVYAARTSIGITGRFVEARLGKPSLVRETSRMTVSQFFTSPVASSRRILGIGVHEQDALKGIVLEDSLDTQLRKVAVSTAHTKKNRAPFRHLLLHGPPGTGKTMFARQLAQHSGLDYAVLTGGDIAPLGREAVTELHKLFDWAKTSRRGLLLFVDEADAFLQSRENSRISEDQRNALNAFLFRTGTESDQFMMVYASNQPAQFDEAVMDRIDEMVEFDLPGPHERRKMIAVYIDKYLLNPPNRWTRKVETIDIGDAEIEEVVRETEGFSGRAISKLAIAWQAAAYGTDGAILDRETFFKTISCGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU96</accession>
    <name>B7FU96_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">High light induced protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Hlip1b</name>
        <name evidence="1" type="ORF">PHATRDRAFT_33932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178556.1">
        <property type="nucleotide sequence ID" value="XM_002178520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU96"/>
    <dbReference type="STRING" id="556484.B7FU96"/>
    <dbReference type="PaxDb" id="2850-Phatr33932"/>
    <dbReference type="GeneID" id="7197712"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33932"/>
    <dbReference type="HOGENOM" id="CLU_1506263_0_0_1"/>
    <dbReference type="InParanoid" id="B7FU96"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="179" mass="18936" checksum="7F60811D61705248" modified="2009-02-10" version="1">MVVIKNVLGITTLVWATEISTATAYAIIVGATSSRKGSVRGSRVGRRKAALVTGSPEVPSRFYRHESPLDQPLVAVPCSPACVGTCMPDTSTAGANHSFLNSRILEQGPRTHEPLAESPLAQLLVLPRRSSSAPSTLMMDLELTLGRASMIAAFILFLVEVATGLSLPEQLACLVTVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUB4</accession>
    <name>B7FUB4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_26157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178292.1">
        <property type="nucleotide sequence ID" value="XM_002178256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUB4"/>
    <dbReference type="SMR" id="B7FUB4"/>
    <dbReference type="PaxDb" id="2850-Phatr26157"/>
    <dbReference type="GeneID" id="7197768"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26157"/>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_1"/>
    <dbReference type="InParanoid" id="B7FUB4"/>
    <dbReference type="OMA" id="QMCCVGG"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02434">
        <property type="entry name" value="Nodulin-21_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="280" mass="30544" checksum="D6FC43E5FADE3170" modified="2009-02-10" version="1">MPSEDTPLVAGSAARDAFQSADAKKSRQYHDAKSASEDGHQTEGGMLKPIIFGGLDGILTSFAIVAGAAGGELSPQVVLILGVSNIFADALSMGVGEFLSSKANNEWILSERAREEWELENYPEGEIKEMVEIFEDKGMSHEDAVSCINTMAKYKDFFVDIMMQQELELQVPDKDHIRESMKEGVVMFCSFAFFGALPLLGYVLFPLEFHDMSEGELFVSACIVTGMVLFFMGSVKSFFSNQQWFIAGMETLLLGGACATVAFTIGQLVKSVYGDDADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUD3</accession>
    <name>B7FUD3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_26176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178302.1">
        <property type="nucleotide sequence ID" value="XM_002178266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUD3"/>
    <dbReference type="FunCoup" id="B7FUD3">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUD3"/>
    <dbReference type="PaxDb" id="2850-Phatr26176"/>
    <dbReference type="GeneID" id="7197777"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26176"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="InParanoid" id="B7FUD3"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="243"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45236" checksum="C1BBAAD88029ACA3" modified="2009-02-10" version="1">MPTYKLHAPEASFRAFSTLIAAEYNGVKIDVSTDLGAASKSPVGKLPLLELPDGSTIFSSHSMARFVAGIRRDSGLTGNTLNEQAAIDAWMDWAGQDLELPACVWFYPVAGYMPFNQSAYEKAKADLGNALAVLDQHLLDKTYLVNHQITLADIVVASTLLYPFKLVADKGYLKPYGNVVRWFQTCVNQPEFQQVVGQVAMCKKELAAAGQETKKTSGGSSKKSEKKPKEDVAALAPAPAPKTEHPYKIMDKEAPSGFSMDAWKKTYSNASSYDAAMQTFWETFDAEGWALWLQVYNYNEDNKRIFMSANAVGGFQQRTDEIRKWAFGVMDVLGTEETVLEIKGIWLLRGDTVEHMVSANDDANWYTWTKLAGKGLPPTDEVKTQVAAYWCSEDELEGKPIQDSKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUK8</accession>
    <name>B7FUK8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178615.1">
        <property type="nucleotide sequence ID" value="XM_002178579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUK8"/>
    <dbReference type="PaxDb" id="2850-Phatr34050"/>
    <dbReference type="GeneID" id="7198091"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34050"/>
    <dbReference type="eggNOG" id="ENOG502S1Q2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1182157_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUK8"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="235" mass="25873" checksum="1775C99498C0C938" modified="2009-02-10" version="1">MAQSAGDSLGLAKKTSISGTSVMNLAGSKLRKQLSSSLQESASAPTSAFAVKQLEKMGWKEGTGLGKKRNGITTHIKVKRRIESAGLGTEKQGTEKLIANETWWKDSVGDTLAKLSSKSKKKKSKRRKEFTDEELFEATGGARFGMRAVPTRNLAKWRRTETEVIGTNSAVAETVPANYTHAVDDNIIIANYETIPGEGKADEIQQEKTRETLRQKPEIFENNKTKKDKKKKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV17</accession>
    <name>B7FV17_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_44959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178845.1">
        <property type="nucleotide sequence ID" value="XM_002178809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV17"/>
    <dbReference type="SMR" id="B7FV17"/>
    <dbReference type="STRING" id="556484.B7FV17"/>
    <dbReference type="PaxDb" id="2850-Phatr44959"/>
    <dbReference type="GeneID" id="7199486"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44959"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV17"/>
    <dbReference type="OMA" id="FSMQEAQ"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852713" description="J domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="394"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="500" mass="56468" checksum="A64E560007EDF5C2" modified="2009-02-10" version="1">MRTIPFQFWTRMLLATALCQHPSVSSLVHAAADDTGTVGLSAGKLRSNAEEAMAVGDYTTAVQYLQEAITLEPESAVNHYKLYRIRHRKRHYLEALRDISQAVELESSASYRKLKAKLLVTLGQCDRAVAELDLLAPNDQDNAQYETAKMCHETIQLAEYHFLNQEYELAAEYFQQAMSFVEIASDLVWPKAKSLFETGDYYGVISDTGMLLKQHPHHVEAYCLRGSAYHRLGEHDQAVLHFREGLKLDPEQADCKKGHKSVKALEKKKAKGDEAYAAGDFESASGHYERAMMLDPTHHAFNRPVQLQLVQTYSKLGQHKKAMDTAQKYVEELESLEGLWALANAQQAADSYEDAVRTFQRAVEVAPDGSEQEREANQKLKNAQVALKQSKEKNYYKILGVSRSATAKEIKSAYRKLALKYHPDKVSDEEKEGADSKFADIGEAYEVLSDQELRTKYDRGEQVFENQGGGPRHQNPFQFYQQQFQQGGGGGGPRVHYRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FV98</accession>
    <name>B7FV98_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_45008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179102.1">
        <property type="nucleotide sequence ID" value="XM_002179066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FV98"/>
    <dbReference type="SMR" id="B7FV98"/>
    <dbReference type="STRING" id="556484.B7FV98"/>
    <dbReference type="PaxDb" id="2850-Phatr45008"/>
    <dbReference type="GeneID" id="7199677"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45008"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569222_0_0_1"/>
    <dbReference type="InParanoid" id="B7FV98"/>
    <dbReference type="OrthoDB" id="191792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852679" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="480" mass="52056" checksum="0EE6489CEB6E0A87" modified="2009-02-10" version="1">MKRTIGKDSLAAWLRRLLPLLLLLLSTDSSFAWSSGSGSSHRPAQAVGAYGQAGRATKLWAGPKSSFLSLSPAILASRPVTSRTTRAPTALSMRVPVLDDWKVLTSGRVTGTVKFHPSIPDGQVITTSPLEKPEAAAARKTIVTSTGSKYQLGSPQTVPAKANGRTQPSNASPAVVSLSELQRQAKLEFALTGEVIGDDDRQYLISGRPQKSTSGKSRIYKAYKANEDGLPTGDSLLIKLSSNTEAIEREASNYAKITKTGLSRGKFVELVDFVQPASVITKKFGSQSALVLERGAIDLKRYISEKGQLSGKEMREAAVSAASCLQAIHNSGLVWTDMKTENFIVTKDGQVKGIDLESAIPVQDNPVDYSPEATPPEFARAFLSGDGPFFVLQYNYDVWSFGMLLYELSTGKGYFDGMTPMQITKMLQGGPEIDLSDVEDDNLRNLIAKCLRLDPKRRPNIVKILLQPYFLISGFGPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVR6</accession>
    <name>B7FVR6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_41875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178751.1">
        <property type="nucleotide sequence ID" value="XM_002178715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVR6"/>
    <dbReference type="STRING" id="556484.B7FVR6"/>
    <dbReference type="PaxDb" id="2850-Phatr41875"/>
    <dbReference type="GeneID" id="7199767"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41875"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FVR6"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="302" mass="32495" checksum="7E37F1B644E1E673" modified="2009-02-10" version="1">MTQALQPESSDGIGVINKQDASPVTVADFAAQAMILRHLKDAFPDDSFIAEESSAALADEAGLANQVLKASQLGDMDALKESIDLGKEYEHWDGSSRPSRVWCLDPIDGTKGFLRGRRDGGQYAVALALLESGTPTIGILGCPNLPSDPKDFSYVWQKDENLENNQQTRGCIFVASKDGGSFQLPILPKSSSKKIDSQAKYGIIARAGAEYYARLPAPGYVEWIWDHAAGKVVVEEAGGSITDTKGKVIDFSLGAKMSDSVHGVLASSGGVFQSALLNAFIEQEAERQAKNADMNQFQKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW47</accession>
    <name>B7FW47_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_44924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179040.1">
        <property type="nucleotide sequence ID" value="XM_002179004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW47"/>
    <dbReference type="PaxDb" id="2850-Phatr44924"/>
    <dbReference type="GeneID" id="7199829"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44924"/>
    <dbReference type="eggNOG" id="ENOG502S69N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374070_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW47"/>
    <dbReference type="OMA" id="RVWITTI"/>
    <dbReference type="OrthoDB" id="49439at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852732" evidence="2">
        <location>
            <begin position="18"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="743" mass="81552" checksum="46A8858108C923D9" modified="2009-02-10" version="1">MQVCAVLAAFWVVSTAAFQGTTWRRSEAKVVSANHKGSTTLLYAESSRPPFFKDLRNPFAALAKGPRSNPQPGDTFADFDPSPSGLVRRTKLVLATDLGLQDPSLLDDQEFKCISPGLDQPLGKTDYIAAGRFFDLRGTFPDLDYRAHDFRIDETDPKTVRLTCRVTGTMRGELRLRTANLPPTNIVMFCPPEAVSMTFNDQGKVTKLCMGFCMDRQVGNTQGTTGVQAAATIAGQPPSNWELYPGLSVVKRFFGRPVTPIVENNAILAPFPETVMVQLAKGVLGSNMGLEDPTLLSNDFAYSTPFIAPVSKFSFLSNYAAEEFANIDPSLSHFRIDPYNPTRVWVDVKPSAPGYEGAPQSYSFTFDDEGFCTRVTARYVLDPSIGNGGGLGGPDGYKYALNDAPSDLLTRPLPEAVGRFRKKILSPITGVGVDDYKLPGEVKKIIPPKPPTVGPNGKSMAPEPLSKLQSISREPPQQDEGTRKAEQEKRVRAQKRAQQEARLQAEQQQKNQASLSAPSLQKKPSYAKPTLNPMFVNPKATLTAAQKAADSKKLVETRNVETAKKKAEAKRQKKIEQKRVEEEQKRQAVSRDLKQSKSISQEQTRLRKDQDGKDFEKRRRKAEQVKEAAKVAAEDRRKRQEAALDALSRAVKSATISLFRLGSGRDEPDELPEQTPPTSKKAPPGVPAITRWRQNDDGSVTGLISGSLNFRSGERVTTSPISSGKVQAGEVVRTGSGSRYFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWA0</accession>
    <name>B7FWA0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179125.1">
        <property type="nucleotide sequence ID" value="XM_002179089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWA0"/>
    <dbReference type="PaxDb" id="2850-Phatr45041"/>
    <dbReference type="GeneID" id="7200063"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45041"/>
    <dbReference type="HOGENOM" id="CLU_835402_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWA0"/>
    <dbReference type="OrthoDB" id="47941at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="73"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="333" mass="36303" checksum="8114C87FA372B58B" modified="2009-02-10" version="1">MKRKEIYGHPDAAVGTIKMDPRVLPVRYRPSSVSARPHRRSSYRSASSSGSSVSTSSKSIDSQNIAPAIALFGAEGKTGHHFLRLALDAGYNVNAYLSPKVSLRSLEEFAHQPSLSVTTGKLEDIEQLEQAISGAQYVVCMLNDTLPGKKEYPAGCLVSFVNRLYPILQRESSVQLLIFQSTSLATSVSGPTPLLSKVVKRAARRRCAFTKDQDAVVRYIAAQHGLRQPKQSNTIIGPEKRSSVGQRSIKADDQSSVTRTDCCDDALPPHFSFIVTRPTILLKDGPPSKTLSASKSQPGLFPVAHVDLAEFTLTALQNEKLYNTSPYVVADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWQ2</accession>
    <name>B7FWQ2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">H2A-3a</name>
        <name evidence="13" type="synonym">H2A-3b</name>
        <name evidence="13" type="ORF">PHATRDRAFT_26802</name>
        <name evidence="12" type="ORF">PHATRDRAFT_34798</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179202.1">
        <property type="nucleotide sequence ID" value="XM_002179166.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179427.1">
        <property type="nucleotide sequence ID" value="XM_002179391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWQ2"/>
    <dbReference type="FunCoup" id="B7FWQ2">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FWQ2"/>
    <dbReference type="PaxDb" id="2850-Phatr26802"/>
    <dbReference type="GeneID" id="7200215"/>
    <dbReference type="GeneID" id="7200222"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_26802"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34798"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="InParanoid" id="B7FWQ2"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="193243at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000009">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H2A"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="HISTONE_H2A"/>
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    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC49025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC49250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="126" mass="13178" checksum="46E29294EB73E1D6" modified="2009-02-10" version="1">MSGKGKGKGGRGDKKSTTASAKAGLQFPVGRIGRYLRQGKYATRMGAGAPVYLAAVLEYLCAEILELAGNAARDNKKSRIVPRHITLAVKNDEELNKLLGGVTIAAGGVLPNIHAILLPKKSGPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWU0</accession>
    <name>B7FWU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_19692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179438.1">
        <property type="nucleotide sequence ID" value="XM_002179402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWU0"/>
    <dbReference type="FunCoup" id="B7FWU0">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FWU0"/>
    <dbReference type="PaxDb" id="2850-Phatr19692"/>
    <dbReference type="GeneID" id="7200091"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19692"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041558_1_0_1"/>
    <dbReference type="InParanoid" id="B7FWU0"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="83"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="356" mass="39163" checksum="D82D24426336F94B" modified="2009-02-10" version="1">MAISSAEAASGTRLTIRLPDDFHHHCRDGAKTAAVLHHAVQRFGYCLMMPNLQPPVTTTEMALNYKSHIMASMPEGSFPYFKPVMTLYLTDKTTPDEIKKASSSGVVGCKFYPAGATTNSALGVTDIKNCYPALQEMSDQNMMLCIHSEVTHADIFDREPVFIEEIMTPLVTDFPNLRISMEHISTKEAVDFVLSSPDNVKASITCHHLLYNRNHMLVGGIRPHLYCLPILKAEIHRLALVKAATSGSKKFFLGTDSAPHSTDMKEAFCGCAGIFTAHAAVELYAEVFDKVGALDKLEAFCSSNGADHYGLERNTATITLEKKSWRVPRTFDFGDGKGVTPLRAGEEIKWSIAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX38</accession>
    <name>B7FX38_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_34932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179270.1">
        <property type="nucleotide sequence ID" value="XM_002179234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX38"/>
    <dbReference type="PaxDb" id="2850-Phatr34932"/>
    <dbReference type="GeneID" id="7200160"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34932"/>
    <dbReference type="HOGENOM" id="CLU_1484766_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX38"/>
    <dbReference type="OrthoDB" id="53731at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855563" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="182" mass="18899" checksum="BFB43FDE78ED459F" modified="2009-02-10" version="1">MMSRLGAACVCLLLYSSSGFAPAVPDHNTAVRLSAKADASRSGGAARFFGIVTASVVSFHATNALAAPANDPSLLHFSSSIQIADSVRIMDMSLPSYGDLKDAKASVANVEGLTLPDTPRAGSSYAASQKAAPSTSPMSSVLPSMGKSAKKEKAPRIDQPAEAKDIMPNVKTMDSSMPKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX94</accession>
    <name>B7FX94_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_34991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179514.1">
        <property type="nucleotide sequence ID" value="XM_002179478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX94"/>
    <dbReference type="PaxDb" id="2850-Phatr34991"/>
    <dbReference type="GeneID" id="7200018"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34991"/>
    <dbReference type="HOGENOM" id="CLU_967936_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX94"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC49337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="288" mass="31737" checksum="59A49B5F4A5660E3" modified="2009-02-10" version="1">MRAVASKRFLLAQVPRSAHRALSATTYAGNRLLAGRSQLNPYTPLELQRKAFSTTGNTTTHASNRSKQETMESVHQEMKGVLQPQKSASPPVAGSGVTAQIFENPKRKAQYNQALWNAAGSFLLVIFAAQSLKSGTQRRKAEQLADGYCTVVEKKRILFQSLLQEDTWKPLAARIAANLNQVNDSTATTAQGIAGLFATRKSPTKTQDNLQQSEERILAMILHEMHVLVQEAALSDTEKDALAVAGLQNKADFLAKSTDDDNTEQLLRDLQVFDKEEGKVVKRRVFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXE3</accession>
    <name>B7FXE3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_45356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179322.1">
        <property type="nucleotide sequence ID" value="XM_002179286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXE3"/>
    <dbReference type="STRING" id="556484.B7FXE3"/>
    <dbReference type="PaxDb" id="2850-Phatr45356"/>
    <dbReference type="GeneID" id="7199986"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45356"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763898_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXE3"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="479" mass="53029" checksum="B85A922B02D555B1" modified="2009-02-10" version="1">MSLIEEQEKALQAKLSSLDGPDWDSEDDDGLQKSAEEDAALAKTKKGKAAGKHGKKGRNKPGTVLYLGHLPPNFEEQEIWKFLQQFGKVLHVRLARSKKTGGGKGYGFVEMQRPDVANIVADTLSGYILFGQKRLVCHVIPPEKVHRRLFFAHAPRAKKEVSRVLALEKIKDITTRLISRERKKRETLKELGIDYDFPGYEASANQVTSKEAEKLDAMAAERNKNARKESVESIGSEGAKSTKTNRVDSVACENSESAQLKRRKELTDDVDRSGSKFAKKTRKDSIASVESTGSKTKKDRRRKHSDGSVNDVNVDIVSPPDKSPKRSTRNKPAKAVAEADPKKLVVQSEKKPKQKLNKRRRSTYQVAPMKALSCIVVTLFVIVVDATSGHPSSAFGRRGTRASSSNSSAESHWSSTGVQGLGHDESRSEKIKQVKKKTDKGLGKEQRHNNSSQRNLMQKVPQAGSVFRMDPLDPNLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXM6</accession>
    <name>B7FXM6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179794.1">
        <property type="nucleotide sequence ID" value="XM_002179758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXM6"/>
    <dbReference type="PaxDb" id="2850-Phatr45423"/>
    <dbReference type="GeneID" id="7200539"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45423"/>
    <dbReference type="eggNOG" id="ENOG502SA5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556073_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXM6"/>
    <dbReference type="OrthoDB" id="46235at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="491" mass="54613" checksum="2B01AB0E8BABDA7A" modified="2009-02-10" version="1">MVEPGLKTEARRRPWLVPAGPRLCRIGLACLALTTVVGGSSQQWGTGSTAASALSSGEKPVGRSSPSSPFLDDRRDPGDTTYDDVESEATTPPVSRYTHRSNTTPPPPPPEAQYSSSRPPFESTRTPIHYQFQTRSPEGRQKKPNFVERDDLPQTYSDLIKDNFDDNVDSNYASPRNDAIGRYMSTSRGKALLLLSSGTVGGAIGAFLGKSLLNRPFALSIPFFFTFWIAANLRNSYGEFVKALGMTLIFAVQRSRRIRKTYPTFCHVKALIGAAQRREFPPIENPWAYVPLEEGDVEFKMLYSVIAMGFVGSACGGNLPLIPAWIGALAGAGSFAFWTTARNAQGDLARTIGMRVVSLAQEILQINYELELLSKFGVVSGKVLDKLLILDRKHRIKDRLIAGTSWAYDRISRTAAEVQNDMQSPSRGGDERFSGNRRPRDGDDRFDRRDPAQGREWSQGMRRRPPTEEREEQPYGDSRARRYDPHDGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FXW9</accession>
    <name>B7FXW9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179632.1">
        <property type="nucleotide sequence ID" value="XM_002179596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FXW9"/>
    <dbReference type="PaxDb" id="2850-Phatr45503"/>
    <dbReference type="GeneID" id="7200587"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45503"/>
    <dbReference type="HOGENOM" id="CLU_617489_0_0_1"/>
    <dbReference type="InParanoid" id="B7FXW9"/>
    <dbReference type="OrthoDB" id="47003at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47817" checksum="033FCC28A7575231" modified="2009-02-10" version="1">MANTPRSPRTSAKKQRQHQALQESPGTSVETETEMETSPAEASGPTPKMAAARRRRLLIGLIVFLLLVLVGVAVGIIVSSMSSGSSSQRENQDGLGNDNSNSGEPPSSATPEGSTPSSPTDGSGSLTTAPETPITDGSGVPSETTGFVPNSAPTTSPEASLTFSTAPSGEASATPSLAAVAIPPGITTFRVIGDVPYTPRQARELVVQMNAIPLDTEFIVHVGDIRNGGDKLVCYLSEYESVDEILSLSPVPLFLIMGDNEWNDCPNVDEGLTMWNNLFTAYESKYWTHNFNITRLAGWESTTFAFLNKGTLFIGLNLVGGRVVNRSAWDRRLADQASWTIGLIREHMVPTVIFGHAFPTENHDPFFYPMTEFIRDELQNSLPIVYMNGDKHQWLYEPSFYGQTSWTRIMVTGGSREPPLKMVVDPNNLANFHTFDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY53</accession>
    <name>B7FY53_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179679.1">
        <property type="nucleotide sequence ID" value="XM_002179643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY53"/>
    <dbReference type="PaxDb" id="2850-Phatr45577"/>
    <dbReference type="GeneID" id="7200362"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45577"/>
    <dbReference type="HOGENOM" id="CLU_402547_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY53"/>
    <dbReference type="OrthoDB" id="54491at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="679" mass="74780" checksum="3311E60F7D5985B8" modified="2009-02-10" version="1">MRPPAYGAKLKKKRQHTSSVDLDSIHPYRDGGPLQRAIQDDLLDVRPLFCDSVASLSEGCNVHHPNGAAFAIYKAVFGSAKLALLHTRVVPCRVDREAYTQLLYAASFNLLHKSFCEKTFEFTHAAFALFSLFVLYHTCPLDTVPPIAGSNKDERLEMFPLGIRDPQNPRRLYQRAFHQRIRIDQLHYEYLDRLRDIALAQIGKCEERKWQADLDRVTAAVNIAPPSCECSLATDVVAVLDRLRENFEFCSYTGPMGLEALAGHSAYPFPESKVAWSTLGRYSSFDTTHNTSEFSSGNPCESKEWHADLQNSLDNYLVCLQSIRLPPVNQGTNIKFKRIREGLLGIFKKTRSTDFLSKLSDILHGRQNALSIYVKPQTVSFGSIIHIENAVQQNAERKQSPGNETERISEQVLLADREHWGTDLGPSFELLLPSNISPEMQRSLQDAFETLLDRKEGYAQQQAMTLASLDEVSTAGELSTLGRSMESSTTLGVGQGALQALLSKASEAVEDVRHQSIPFGGFFLSTEEDDDISTQPRNAMNKYGEAESIDDDAVSVATESVGRAALDRLLSAVCPLPPTPAHSRQSVTPSRKVNAKRKRSLSFSLAASTPRKRPALNPSGLPTKDESSTNESLGEGNTGYSTEDSDGDDSLLSAFSSESGTTGQGSSALNVLLSTVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FY92</accession>
    <name>B7FY92_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_35346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179694.1">
        <property type="nucleotide sequence ID" value="XM_002179658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FY92"/>
    <dbReference type="PaxDb" id="2850-Phatr35346"/>
    <dbReference type="GeneID" id="7200649"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35346"/>
    <dbReference type="HOGENOM" id="CLU_697310_0_0_1"/>
    <dbReference type="InParanoid" id="B7FY92"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="396" mass="43906" checksum="A7D4D6AB2F77A191" modified="2009-02-10" version="1">MFSLRLRRLLISGDSDTNKEDKPTPTTEDDYRVQIVSSSTRSNRTAMKKEYSRRGSTSGIFGRAKEPPSKRTPSSKELAVLATTASTDSKCTTERTQSICSIQPGPEKIVSKTRSHCSMVNSKHNSSRTKQTVETLDVDTPSPSVHSRSLPNGRSGRRRSLLSNDTSSSKTREWDPAIFVVDFAGQANKAPANLVSPSCARESPLSTNTHYFIPDSNHGQRSTYTLPKECSVQDGGLELLNGRTQIPLRRRSSLSGQIRMPALLTTSITKTPWNQNLFTVDCNSISDDRSDDHVLLIENKPTKQGEIMLGGRDLDDTEDPSMLLNADAVSVVTASTCSDLTMGDPTMIKLYDKNGCLRKDLLIAMENGRPTMRKQADAKFVKPKYITFRRKERLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYD8</accession>
    <name>B7FYD8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ADK</name>
        <name evidence="8" type="ORF">PHATRDRAFT_20093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179918.1">
        <property type="nucleotide sequence ID" value="XM_002179882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYD8"/>
    <dbReference type="STRING" id="556484.B7FYD8"/>
    <dbReference type="PaxDb" id="2850-Phatr12239"/>
    <dbReference type="GeneID" id="7200437"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_20093"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_6_0_1"/>
    <dbReference type="InParanoid" id="B7FYD8"/>
    <dbReference type="OMA" id="YHEMLDG"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852813" evidence="7">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC48904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="316" mass="34175" checksum="70CA5E92E80F847F" modified="2009-02-10" version="1">MLRSLAFTASVALLFSLDPLLAFAPIRTTTSVASPSGVSIRAQTGDQLFAAAQDDNFEGIDLVKLLGKKQLKRMARKSQSHRRSDKPAGPKASIGAGFVAKDPVKIIIAGAPASGKGTQCETIKEKFGVVHLSTGDMLRAAVAAQTPVGKQAKEYMDSGKLVPDDVIIGVVKNRLIEKDCQSQGWLLDGFPRTQAQALALEDAGVCADCFIFLNVPDSVLVERVVGRRTDPDTGKIYHMTFSPPEDEEIKARLVQRSDDTEQKVKVRLEQFHDNVDAVKDKYTNIMVTVDGNQAPTQVSKEILEAIEEKVGSKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYQ9</accession>
    <name>B7FYQ9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_12262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180017.1">
        <property type="nucleotide sequence ID" value="XM_002179981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYQ9"/>
    <dbReference type="STRING" id="556484.B7FYQ9"/>
    <dbReference type="PaxDb" id="2850-Phatr12262"/>
    <dbReference type="GeneID" id="7200813"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_12262"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_910499_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYQ9"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF104">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC48208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20253" checksum="10EA008B8B43DAC7" modified="2009-02-10" version="1" fragment="single">YESHLHARPVVTKMFTGSLLWGIGDAVAQIVPFLSAGKDSVDGVTAFTYDWPRTTRAAFFGFAIHAPLSHLHFNFLEWMTIRLKVQGLAIPIFKAFMEQFVYWSWFSNSLYHGAMGAMQGQNASQIYDRIANVLWETQLAQWKFWIPIQLVNFQFTPVRHQLNVVLVTSIAWTALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZR5</accession>
    <name>B7FZR5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoprotein TPR/MLP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_35556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179992.1">
        <property type="nucleotide sequence ID" value="XM_002179956.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FZR5"/>
    <dbReference type="PaxDb" id="2850-Phatr35556"/>
    <dbReference type="GeneID" id="7200910"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35556"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236159_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZR5"/>
    <dbReference type="OrthoDB" id="199538at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="4">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1437"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1835"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="687"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="800"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1565"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1576"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1705"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1737"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1774"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1805"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1861"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1902" mass="213331" checksum="BDB5AA1B8884A476" modified="2009-02-10" version="1">MSSPSDETIAGPPSSPTTEDAGTQARKASAALTSKVMLEELERQYMQIKGERDDLQQELTAAEEKFKTLNESLTSNQALEVENAARQHELRVAQERVKALEEEQTATKERTDRAQAESDRLREEIARLAGSNRELSENIATFEVQSKLSESQAIPLFHEKQRLQTELDSLQAHANWLEQELTAKSQDYQKLQRESRDRSIQLQLQLDQTINEKEAFEARLDELHKMERRLQDKVEELSHDLLTGKQAMTDLQESTEIEIREERRLVQLQKTHLDRWEHRYNDVVRENESLKKAATEAMETSRSELLQTSEALENKYKDLLREQAAEYEEKLKSNRLEAGPVRLALPAPPAAVATDYEDDVPLNLTDLYTRLEETKATLRRETARADRAELLNERIQKDIAAKAPLLNRQREEYDFALDQIQNYQRRLEQALNEVDNAREDSKETRRDANRLQKLLSERTSESKELAKQVQALLVTRAGGQVGEEIPTSIVEIQNQNQRLLAEHRRLTETVRELESKLESDTLKAKLDAVEAELADLREDRQRQETAVERIVQQRDLYRAILSKQDANVLGSESEQLSAMEIAKQQSERYKALDQKSKTLASDLAAARGEIDRMGRERESMVERLARYEAHSAEMKAAVDTLERELLSARGDAARSNSESLYHRERAERVEESLQRARDEISMIGSSKAELQRINTDLQQRVDIVRSESSRVATEVRQAEMKARLAETQVETAKASESRMAEEVNQLRGEVSRQGSIIESIRRIEASLSAKSGSEREVLKSELEKLSQVHKSEQTSFNTKIENLNARIQEMDSRVVAANDSKDKFQSELSSVKDELNAVTAERQELNLKARRLEAQLRAAKKKLGEGDDLDDVEVALQARIEHLTNQLEETKSELANSKKQADTYQLISKNAESALAELSQATETMKATNESEVLELNGRLEKLQKENASKQEIVLDLTKDLLSQRGEQEKVESILKSEIESLKSEMKTREQDSESSAAGTAALKLDLDAMRTEVATAQGNYERELQLHSQARTALREAREQAQEETRLRHIAEEKTDASAREFDQQKNVWEQEKLSANENAKMIEESLKEAREQNRVLHMQLESLGAMVEESQMSRAVAASEIPEPGNSSEQMNLQKMLSELREILKFVRSENEILQTQLDTAKRAADRERTTFQVVKRSLDEARAELKSLQNQDIMDKDLPGNNSAEQLRDAVEQLTLLRDSNKLLRDDADKLQSNLTATQNDLNALKSSRKPAEKVQRELEARIASAEAEKESLNRDLAAWKSRVESLLSKFNQIDPEEYEKVLRQVEELTKEKESLTAWKKTTEAENTRIREICRNLKKHISELKKTIEEQKKDIDKLTTEKATLTTKSTEGTSAAKERDELKGKLSQAEKDTASTKTELDGANHQNEILRERMRQMVKTSNELRKKERELVGQLAEAKSATQTDSIQDKLGKPSENASEKRTLASSKIGISTPTFSATTPESTQRTAGLVDVRAPQILPTIPTNGFRFGPSTKPKPKSPMAVSEDVLQAKSEEKIETRGASELKEPTSVFSEKAPEFVPHSQMSTKTETNISSTSGSSPLQSGGDVADAKQRSSGELATTTHATPSESQELSMKKEKLLEKKRLLADAKKRKIQAEAEARKTDTDGLQQVAKKPKTEDTEKESRLIGAEVGDRTLTAGTMSEQETSNSAEVLLEADKTESELVEVENLDNEEPSKSEIAENETEPAFKPSCFGSGSTATTSPFTKSNPATPFGRSDAFGQSATVLPGAPTTFGVTSSTVQSSSGFGEAFLSQMKPPGGSATPPSFSFGSSEIPGQQFQASASVFGSFGGKSTLGSLAGSKEPSMAAFPFASQPAVQENKEQNDDAKDATELEQTEEDVHWARLPGSRKPHFQKPPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7G045</accession>
    <name>B7G045_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_36006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180614.1">
        <property type="nucleotide sequence ID" value="XM_002180578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G045"/>
    <dbReference type="PaxDb" id="2850-Phatr36006"/>
    <dbReference type="GeneID" id="7201347"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36006"/>
    <dbReference type="HOGENOM" id="CLU_075196_0_0_1"/>
    <dbReference type="InParanoid" id="B7G045"/>
    <dbReference type="OrthoDB" id="4455at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852821" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28723" checksum="0A2DC7976AD4088E" modified="2009-02-10" version="1">MKFTAPNVALFLLAALQATATSVHATRFCKEHGALIPVTVVSATSPDADGLKDGFEVFRDLLGGENNGNGAAPSAEGHRQVNWDAPIVPFDMPGDFFATTVDRGLNLRSKRDEFRVSNPDPKDGPKDDLFDSISPRAAKDFQTFSAFRLFTVAGGDNEFVAEFTVPGSHKEATVAGFGAVLVDVDLSHKTTLTFYADSGCIIAQEDAKALKDGLSFVGLVSQSEKFPIAKVEVELGTKAIEDTSRRGRTDFVVMDDFLYSEPQELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0L2</accession>
    <name>B7G0L2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_5738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC48107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180699.1">
        <property type="nucleotide sequence ID" value="XM_002180663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0L2"/>
    <dbReference type="FunCoup" id="B7G0L2">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G0L2"/>
    <dbReference type="PaxDb" id="2850-Phatr5738"/>
    <dbReference type="GeneID" id="7201460"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5738"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G0L2"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="27858" checksum="98432A55CC0EF9C5" modified="2009-02-10" version="1" fragment="single">DALVVLDVTHSNLEQRHAELRFAKHDSLETLRTRIHQKTGTSAQFQHLLVYDNHDDNSLLHEIPPETSDDIKLGYFGILHHGMRVHCVDLNPHSGSAGGAYEDVSLVEKYRMTEDEYDARKGTLRDWGRQQRELVVDEPDVVAPIKMSEMVGSDEYGLDSVAHCQVGQRCQVEPGQRRGEIAFIGKLSQEKPGHWVGVRFDEPVGQNNGVDNGVVFFEAMDRYGAFVRGKKVVTGDFPERDIFDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0V8</accession>
    <name>B7G0V8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_54560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180934.1">
        <property type="nucleotide sequence ID" value="XM_002180898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0V8"/>
    <dbReference type="STRING" id="556484.B7G0V8"/>
    <dbReference type="PaxDb" id="2850-Phatr54560"/>
    <dbReference type="GeneID" id="7201610"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54560"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_3_0_1"/>
    <dbReference type="InParanoid" id="B7G0V8"/>
    <dbReference type="OMA" id="DEEHYYG"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="82"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="526" mass="55926" checksum="63FAD276679CFA54" modified="2009-02-10" version="1">MASAAASPTAEQTAASRAESSREVLSGERLTAAETVPIASANSIHLSSILPRYSNYNVRVDKDRSDRALEIRLLSSQRPHMRAFYCATISFFAAFGMWFSVSPFLGIIGEELSLSRSQLWLSTICSDVATILSRFVVGPACDFYGARLPMAVVLILSSIPTALTGTVRSFAGLCAVRFGTGIAGSAFVMAQYWMGQMFCQEIIGTANAIVAGWGNSGGGVIQVLLGTGLYPFLKEASGNDEAWRFVFVVPAVFAIAVAIVIVKSSDDAPLGYYREMKRNGTMDLHHSTMMSGTTSRNAWLLAVAYACSFGVEITFNNAASLYFRDEFGASTSSAAALASIFGLTNLYARACGGIVSDLMNQHWGMWGRLSWGCIAIVIQGASIIAFGYADTLTSAVPLLILLSSCVNATEGAIFGIVPYVNPAVAGSIAGIVGLGGNVGGVCFALAFHSLSYLQAFKVMGAVAMASSAIFFFVDIPGHATLTSRSKSLKAINARRETTERLPMDQDEDRIQESRRSKDDATIPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0W9</accession>
    <name>B7G0W9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_46347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180938.1">
        <property type="nucleotide sequence ID" value="XM_002180902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0W9"/>
    <dbReference type="STRING" id="556484.B7G0W9"/>
    <dbReference type="PaxDb" id="2850-Phatr46347"/>
    <dbReference type="GeneID" id="7201617"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46347"/>
    <dbReference type="eggNOG" id="ENOG502S2V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1091787_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0W9"/>
    <dbReference type="OrthoDB" id="10260865at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010292">
        <property type="entry name" value="Uncharacterised_CreA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37952">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37952:SF2">
        <property type="entry name" value="PROTEIN CREA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05981">
        <property type="entry name" value="CreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852890" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="255" mass="27361" checksum="B6DEBF90D2CF2A5A" modified="2009-02-10" version="1">MKLLVAAVVLLLGLAASPTDAWTFPGAPFHKPVVRSVSTDASQRPQQAFHSQQDRTLCQPPVTVRPSRVTTAVLGWCAAIILGAAAPWPAVANDARVVGQLQGSGLVFKDTLQIEAFDDPKIQGVTLYISNFQKPITERLNAGFFNDPSYASVACAQTSPNIRVADNINVSPQGEQVFTESKSLLFKSLRVQRIYDVDKQTAVYVSFNTRLDKSDDSNKSRFKSSLCAVPLSNNNKATAANSVADAVAKAPVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0Z4</accession>
    <name>B7G0Z4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_46366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180761.1">
        <property type="nucleotide sequence ID" value="XM_002180725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0Z4"/>
    <dbReference type="SMR" id="B7G0Z4"/>
    <dbReference type="STRING" id="556484.B7G0Z4"/>
    <dbReference type="PaxDb" id="2850-Phatr46366"/>
    <dbReference type="GeneID" id="7201632"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46366"/>
    <dbReference type="eggNOG" id="ENOG502QSQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310260_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0Z4"/>
    <dbReference type="OrthoDB" id="42582at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855596" evidence="10">
        <location>
            <begin position="29"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="519" mass="57847" checksum="793D09566EF0AEDA" modified="2009-02-10" version="1">MVLQKRLTRGLSFAVILFLASTANKAAAFQASLVSSRTVSRSFDTAIGPVAKDIEPSPLSYSEKSRLYRRDFYDHDSWLKHRAKNRFVGTLSKVLDSGVVRQLADEVILIGAVATFVCVFNALCVTGYEDFSNLHHDPIFNFGAPLVKLPGEPFSLSSPALSLLLVFKTNTSYQRWDEARKAWGVIVNNSRTVIRETSAWVLQSDLSDEEKYRLIRRVADCVWLFPRSLQRHLLNPAEDEEAYVKDVRAKLDPVLAEDLVSARHRPTRAMYEMSKAVNTLPLDSYQRSTIDQGVSQLCDACGGCERIFGSPVPSIYTRHAARFIELWMFFLPLALYSPFSISWNHWFMIPSSMIIGFFLLGIEELAIQLEEPFSVLPLGKIASGIGLSAEEHVQWAEEQMAIDRTSGPSSYGYPAPIPESTVVSRGPTYSTPTCQLQQTPVPLANGGFSYLNNPSQQSISTSELDNDESSYQEPPTEQRQPPVVATGDYSYLNPPALSEDGQPQNGGLTYQFGPPRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7G1L3</accession>
    <name>B7G1L3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_46547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000613">
        <property type="protein sequence ID" value="EEC47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181049.1">
        <property type="nucleotide sequence ID" value="XM_002181013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G1L3"/>
    <dbReference type="PaxDb" id="2850-Phatr46547"/>
    <dbReference type="GeneID" id="7201690"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46547"/>
    <dbReference type="HOGENOM" id="CLU_035468_0_0_1"/>
    <dbReference type="InParanoid" id="B7G1L3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852855" evidence="2">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="464" mass="46896" checksum="0268CE7B0599562A" modified="2009-02-10" version="1">MLFKLAIIWATLTSATQAQNSACTAATSISALPASVSGDTSNVSPVQDVAAESCQLARGPLASSWYSYVAESDGCLTAKVTPPAADEWDTILTAHSGDSCSALSCVAMNDDVDVVTERGSEVRINAVTGTTYYFMVAGYDNDEPGGRFEFALSQTSDATCSNPTGNQWCPICPDGGQPSATAIFDENVLCSGAGADEESVEGDEACGILQVIGSAVCGCTPASTATCSLCPSSEPISSPMQSILVSETVTCGDISVVGGSDSCGANRDGLAALCGCPGSGPVCQLCPAGSSFDPNRFVSPDDELTCGEIELDFRKEVILFPSIGCTPSAVDFVFQANVVDFCCNGANLESNPNLTFPPTGSTPNGAPMAMPMTTLSPAATTAPESAPTGAPQASSPTVINTSTPGSVTTTSPMATPVTTTAPATTPTSETPNSATPTSSPPVSQPAGTSDASRSRISVSAFKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B7G252</accession>
    <name>B7G252_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_13789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181317.1">
        <property type="nucleotide sequence ID" value="XM_002181281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G252"/>
    <dbReference type="STRING" id="556484.B7G252"/>
    <dbReference type="PaxDb" id="2850-Phatr13789"/>
    <dbReference type="GeneID" id="7202242"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_13789"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="InParanoid" id="B7G252"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="211" mass="23678" checksum="66833AC0446A0100" modified="2009-02-10" version="1">MLILGKPGGGKGTISGKILKDFPRFHHVSTGDLLRQHVNEGTQLGKEAKSFMESGKLVPDSLMINLLMDDAKPYIEEGRSLLLDGFPRTLQQAQALEEVAHIDTVVNLDIPTNTIVERIADRWIHPASGRIYSYSYKPPKAVGKDDVTGEPLVQRDDDKPESVRTRLAAYDKVTAPLVDWYRRKGLVQTFRGTESDVIYPQVKAYLEEKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G271</accession>
    <name>B7G271_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181328.1">
        <property type="nucleotide sequence ID" value="XM_002181292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G271"/>
    <dbReference type="STRING" id="556484.B7G271"/>
    <dbReference type="PaxDb" id="2850-Phatr47025"/>
    <dbReference type="GeneID" id="7202113"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47025"/>
    <dbReference type="eggNOG" id="ENOG502T743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389091_0_0_1"/>
    <dbReference type="InParanoid" id="B7G271"/>
    <dbReference type="OrthoDB" id="186866at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511">
        <property type="entry name" value="ALANINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511:SF0">
        <property type="entry name" value="ALANINE RACEMASE, CATABOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase C-terminal" evidence="5">
        <location>
            <begin position="570"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="710" mass="76160" checksum="8A16983302937003" modified="2009-02-10" version="1">MSAPTESIFVPDRRKVAARLTNGPAPPPPPEDKHRAVHRIRLSALQHNFAFVESTAARQRCSVIAVVKADGYGHGAIATALHLADRCGADAFAVATLEEAISLRRAFERNPPGRWSKQLAALFHTGGIDTATTSLDTASAGTSRPNSPQSEVAARVMRPAQIRILVLGPPVGFPRCFDDYYHHGIEVMVSGPEVVQALMEWVLNEKERKRTQVQRAAMEAKAHALTAPMAPRESANWDEKKDSRENLLLSDPQGLSDPSGDNHKKALRHPSSTLGNVSGQDLANEVRAMLIKQKAATDAANVSAATGIVPKASTSNVASTVNSSESSVSSDPKSAMTPPKSNVTVNSQHSQYPGTKQLFGGIEAAARTSRNRAQAAAHVAAIFHESEHEASAQQPLAPNNSQSTAPANSSFPIPAGSTPATRKRLRWHALVDSGMGRLGFKTEPVKKEDALAGRRDTVEILQDMLDAEINGNAPIEFYGMCTHMAEATATSDFTKSQIAKFINLLKRVRSAGIYIPTVSTDNSAALLTTNLTHFNPSEILSQKDSDTRGFVRTGGAIYGQRPAFDELQAVSTLLASVRHVAILKQGESVGYDRAYIAPYNVRIATLTIGFADGYPRELGNGVGKVQIRGSVFPVAGNVCMDMLMIELGPAEDTDIGSTVAVGDTAVLWGPLDENDDYGMVRLQDLATTLKTTQSALTCGLDKIRVLRQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B7G279</accession>
    <name>B7G279_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_37131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181332.1">
        <property type="nucleotide sequence ID" value="XM_002181296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G279"/>
    <dbReference type="FunCoup" id="B7G279">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G279"/>
    <dbReference type="PaxDb" id="2850-Phatr37131"/>
    <dbReference type="GeneID" id="7202117"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37131"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="B7G279"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="577" mass="61859" checksum="9F01FC353863EB18" modified="2009-02-10" version="1">MRPGIILLREGTDTSQGTPQLISNINACQAVADTVRTTLGPSGRDKLIATGRHVTISNDGATIMKLLEIEHPAAKTLVDISMSQDAEVGDGTTSVVLLAAEILAKMKPFVEEGVHPQILQRNIRNAGKMAVEKVQELAVPFQGDELEDMLLKTARTALNSKLIANHKDLFAPMVVEAVQALHQGGSLDDLSSLVAIKQISGGDVRQSFLVNGVAFKKTFSYAGFEQMTKQFTNPGILLLNVELELKSEKENAEVRITDPSQYQSIVDAEWKVIYDKLDACVDSGAQIVLSKLPIGDLATQYFADRGLFCAGRVTDGDLKRVAKATGGSVQTSTHGITKDMLGTCGVFEERQVGDERFNVFTDCPQKLTSTIVLRGGTEQFIAESERSVHDALMVVKRSLQSGSVVAGGGAVEMEVSRCLREHALTIEGKGQLIITAYAKALEVIPRQLCENAGYDSTDILAALRRKHAVDADGKWYGVDVINGHICDTFDLGVWEPSDNKVNSFDAATEAACVILSIDETVMAPKSQDPNAHHTGQMDQGNKPMSNMMGGAMQAAQGGARSGQLGPGVSYMKGRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7G331</accession>
    <name>B7G331_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181547.1">
        <property type="nucleotide sequence ID" value="XM_002181511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G331"/>
    <dbReference type="PaxDb" id="2850-Phatr47359"/>
    <dbReference type="GeneID" id="7202511"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47359"/>
    <dbReference type="HOGENOM" id="CLU_506685_0_0_1"/>
    <dbReference type="InParanoid" id="B7G331"/>
    <dbReference type="OrthoDB" id="44787at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55344" checksum="937647068DB8C3A2" modified="2009-02-10" version="1">MVAKAMPKLRMDGSPLKRPRSIDLPKIDVNEAIAHLQRALTTKQRLMALHHVQNLIEGDPTAISWMVDSGLIRILQLQLSYALQRHGSTSQELGTLCQVFDLALRTSPAGSLESALDKEAGRSLVNLVADAFPWGFHHVIVSILHTISQTSSGAFLILHCSKAMHCVTELFRCCRASSTSKEAVFEALGLLKNLTYFSEESRNILLDLPGIVGSLANVAVFVDQKGHERLSAIWRNLSVSMETRRRLAQDPDVLNGLLELADCTCSYALRNLLNTTISLSMDPESCVILVLHGDGIFVNVLRRLLVTETDALIRKRAARVIKLWASNDFVGPILVKDRALMDVLSQQALQDQNVDVRHEAADAFCRCSQRIQSPMPQHQLVLDAIMFLAEQSRLPAEVLARTLKAQALHPRNRIPMAERNSLLSALARIAQQEGVPNSAREDACCALAYLSDEAANLPKLSTAGIVEAVTYSRESSQASYTYKSSSGSDTICGYFNRRPTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3D5</accession>
    <name>B7G3D5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA synthetases class I catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_2394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181599.1">
        <property type="nucleotide sequence ID" value="XM_002181563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3D5"/>
    <dbReference type="STRING" id="556484.B7G3D5"/>
    <dbReference type="PaxDb" id="2850-Phatr2394"/>
    <dbReference type="GeneID" id="7202563"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2394"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_3_2_1"/>
    <dbReference type="InParanoid" id="B7G3D5"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF27">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="5">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="5">
        <location>
            <begin position="59"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="41983" checksum="68E032CD901F9A27" modified="2009-02-10" version="1" fragment="single">IAFYTCGPTVYAPAHLGHARTYVCLDIVRRVLEHQYAQHRGGSSNSTMPSSPVPPPPLFVMNVTDVDDKILATAAARDETDSLSSPLALARHYEAAFWSDLDRLNVLRPHVVTRVTEHVETAILPYIQRLVDNGTAYCATSGDVYFDVRAFEDRTNARTRYGKLAPPVSATDFYSRLDQTAETVKRDPRDFVLWKRRKEGEALFWTAPVWGEGRPGWHIECSAMIQAVQEQFQQTHRFVVHAGGVDLQFPHHTNEIAQAEAHVLPDLDNVTDTTLPVQEWIPHWIHTGHVHIDGLKMSKSLKNFVSIEELLQDDNPSSLSSPADDFRLWCLGMSGSYRGPATYSRDAVSQSSHVREKLVRFLLDGERWLSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3P3</accession>
    <name>B7G3P3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181469.1">
        <property type="nucleotide sequence ID" value="XM_002181433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3P3"/>
    <dbReference type="STRING" id="556484.B7G3P3"/>
    <dbReference type="PaxDb" id="2850-Phatr47243"/>
    <dbReference type="GeneID" id="7202335"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47243"/>
    <dbReference type="eggNOG" id="ENOG502RRC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332482_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3P3"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="850" mass="96063" checksum="30EF03E0D160F5AE" modified="2009-02-10" version="1">MDFANGFGDSSDDLMENARIVSPYGDGETQAFPADPWANFQYALPEGSSQYKYRASRQRPTIGGSRSPSEPIPTPRERMVTSSKISTPHRHGMVNRGHASRYEYSSDKRCDDVHVIFTDPSDGVGISVEKRSQQDLLRQKVREDTSRRSLQHSTSAQSMYRKRSENKVEITSESTNAETDGLNLNWAFSRVQVRANSETESTTVWLNTDHRQDLEGEDIWLQEEHAFPLLSTGASSRFSGPSGKDGLRKRTDKKLNRVRFAEPIQKPRSVPFLKTVSRETIREESSDPRSKKITHSDNRAWFVAQPKSILRRRRFAGETVSHDPQYPQKNRPSSHRAAPQRKSATSFLDTQGSLLSPIHSDRRPWDRISETGSESLSPSYSDVEREKRVSLGPYHLQELNEMYPDPPLELQFDDESTVVPARASFIDTVAAVVVQAAVRRFLAQKVVPKKYGRNLGGAVFIEVMAAIKIQSAFRGFWVRDSLNVDHFCATMIQKWYRRHHQRHHYFADLSRIILVQSIWRRSIAREHAAFFLGSVITVQSLFRSYSARKKLYSGLTCLRKDTMAAVVIQSHWRTYACECNFIRDLVDILIVQSVVRTWLARRHLSSLRSRAQSISGKKSPTVSKKYANQVAAQPTGSPRPGEANRNSATGQCYSSYRSVEESSFSAILGNIKSKENNHLIVLITSQSLSRNQASTRSNIGTILRVHNVSFEEVDGANPLTRGRRDELFAISQMRGVYPQFFVVDYETGLTLFFCNSDSFFGANEEGSLPRILNIAGVVQSAIGGHQERNSTIDEAPKANKHLFEPKRQSSHTTVSIDSETSEPSVGRNSLLSMWKNLDKKNTLVLNGHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7G435</accession>
    <name>B7G435_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_47561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46388.1"/>
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    <dbReference type="GeneID" id="7202627"/>
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        <property type="component" value="Chromosome 14"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5002855393" evidence="3">
        <location>
            <begin position="24"/>
            <end position="521"/>
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            <begin position="323"/>
            <end position="345"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="106"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
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    </evidence>
    <sequence length="521" mass="55682" checksum="6A9FA31B0E8206CF" modified="2009-02-10" version="1">MKFSISSLVVTIGSLGNLPLAIAQGVSATTPVVRYVDPMSDMSLLLPSLSARHGDEPSLNMDFWLPASRALSSSLATDIPDQTYATLPSKASSTAQVAVSTMLQSNVPSDIPSSQPSYIPSSLEDGPPSDSPSLTPSLQLASSFSDVPSNVPSNQPSVTSSLPGASEVSVTQSVTLALGSNTILDDASIDIFERVCAFSFLPMYLSTIYEAEYKSIRCSVLDQNLVDESSKRRLLDEDYTLGEKHSTLSLLLRVSSLVYLRSGVEFGDIVQQTFTTHVDTFLSLLFDTLPFFAPKSSSGSGNSQAITGGQTEVQNQEANPSPIIISVAAVMGGAILAAIAAFFVLNSRRNAILNREMPDGTDVSIPIDYFESSDEDLESAPYDVTDISYSTMGMNMMPPSPLGIDSIPRALNSVSMIHFSEDLSTTSIDPESGITPSSTTLSPGPLIPAYWESYESKMIWKIRNSSSHSLSSQMSTDIQSVNGAFESSPSLLTVNSRQEDVGTTYSDGVKDQSSTTDTYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G467</accession>
    <name>B7G467_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37837</name>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
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    <dbReference type="GeneID" id="7202806"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="105" mass="11438" checksum="3A40611CAACA1632" modified="2009-02-10" version="1">MARFYLFILLAITVVASCEAGWFSRDTGGSVKNAANNLKDDAKWWKANAESQAKVKTEEAKSKAQEAKYNAMSTTEKAKAKANEISAKARKKTSNAFDSAKQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7G562</accession>
    <name>B7G562_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Bacillariophycidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
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                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
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                <person name="Durkin C."/>
                <person name="Falciatore A."/>
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                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
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                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
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                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEC46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="7202989"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47863"/>
    <dbReference type="HOGENOM" id="CLU_251929_0_0_1"/>
    <dbReference type="InParanoid" id="B7G562"/>
    <dbReference type="OrthoDB" id="46236at2759"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1440" mass="161736" checksum="A2039AE3E439D23F" modified="2009-02-10" version="1">MPQTVRKELLSSSMSRSWDQECLIGNNLALLNSDTDDDIATPLYLYETMEPNIHPRTDPQAKANALDNKDASIGFLGHANLPDLPTDVLALVLSHLELLEIAAVSLVSRATYQACRDSVVWKVLLEFRWNVGQGRVSPALLEEDENSSPTTRSMDYYRAYQNAHRNPHTLWIRHRNIVYPGDGLTPGRCCIDSSSCQKHASEADRPRRQGSNNRSKIRLCPHCRARQEAHESHHDEKMDTIETPAQAMAAATRRMHQKFQSSTMWPSVAAASVLVDASKSETDAQALMKQQRRMQQKAFAQAATFHRKLRTTQFESCQLSFLTDLLFFNLTDPATSEGQWELDQLLREALSTTSQTTNIPNQRHRRPHHHLTSPLHETSNHSWHVVQLTNSDFFRPIAFQVYIARPDCFTCYPSAGYLEPGESVSCVIGVRPLGSALAYAFEGLNVAREGLEPAWADLYTAQAHLPLAPLSFRYQFVATVPQRWVSPAHDGDIDNDLAAYRRQANSLYPSDPYATPTERTLDHHGCKSWEAHKVRTVALSAHVHAHYSFQDFLYATGFRSSRFVSITRTNFVAPQLQERFPEIFNRLANSDGSQRRSWKATSSDLLDTFSTLVSKNTERPCSLCNRPWGLRAEELYHALVLSKLTSSSYQFRRDMQLKNLQRCLRVLATNTAKNCLNVRLSKLFVSLFTILQAYKASPWLSLKHKKVLIIWEITLDIFCRQIPVGGANWVPWRFAGIYRHALCTESVHSGPNLLDGANNFEKSEIKEEPDYLDAFRHLAHSPGRYCLGPQEDPNHLDEAIVINSSKYGRRQKGMITDMFMDDPVSTFQAGICMINDPRSLLVHGIFDRIPYPGSIVRRPHWMPLELYIERIEYDDHATNLNVSAGAHLLSSKERTAYFRLQNGMDINSMVGVDPSLRQIAAVSILSHLSMQNYLHNIPPPGVGRFPLSKRASVGQRATTEGAALDIEPLLFHANQQHLEGSSTTVNTTTGQQQALPHATFAVPRRNLPRPPNPRGPRLVQLLWILAAQMGLAVVDTSGDSSVYVDRKILIATQWISISLMIVPLFLTLFSRFLQLIPTQPVDYNLESLPFHVTNKMRFLTEYECGQLAFGLILAWLVLGRWVERYTSRDFLRMIMSPGSITSPQLHRHRWKVFSDWLGLTLSKWWDAICPVFLQSRAFSPEWNRRSRSGMLQHLSYWRSRNLAEQRSYAHASQRAALFGLQQSGLEDFGKVSPSGKIAWGIGVTLVSFASSSPHFWLNLVTIFSCSLSLGMTVSLYAMEHGRVAVTVASGTTSATSSLSQIPVLTVVMLGFLVGQLVGSSGGTLFLAEFVVTAVSLLLGGAGTVSASAMESWICFLCLASTAFGGYLLGRVALMDNIRNKQSGYSSMLLSKAILLLVVFWVLILFVARWDVPVSLVIVRPRLRTDDNVAVSRAQIAKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5M0</accession>
    <name>B7G5M0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_38343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182270.1">
        <property type="nucleotide sequence ID" value="XM_002182234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5M0"/>
    <dbReference type="PaxDb" id="2850-Phatr38343"/>
    <dbReference type="GeneID" id="7202996"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38343"/>
    <dbReference type="HOGENOM" id="CLU_1698953_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5M0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="155" mass="16554" checksum="0A087E83FA263EDE" modified="2009-02-10" version="1">MKFNYYGLKADIYGVLEARLGTFLSLFFLDILFLMSLSFICFRMIFVCTGIRVGLGEGAADGDVDGTFVGTEVGIAEGATAGEALGTLDDTDDVSIDRSAGMAVAVVGWTCVVAIEVGALVGAVFSLLLVVILFRMSFFFICLSRPRKARLLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5X2</accession>
    <name>B7G5X2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine o-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CAT2</name>
        <name evidence="7" type="ORF">PHATRDRAFT_48078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182478.1">
        <property type="nucleotide sequence ID" value="XM_002182442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5X2"/>
    <dbReference type="STRING" id="556484.B7G5X2"/>
    <dbReference type="PaxDb" id="2850-Phatr48078"/>
    <dbReference type="GeneID" id="7203430"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48078"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="B7G5X2"/>
    <dbReference type="OMA" id="DVWAKDY"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="688" mass="77333" checksum="E868AB851046AA9F" modified="2009-02-10" version="1">MWRRGRMSSITSTVTTMATTTRRRANARRILSTSVPLRPWKTSVVESHGDYRAEAWLEDHVGGDLYRYQADLPMLPVPTLAHTLERLLPTVLPVCRHDEEMESLRQAVDRFPEQASTLQERLLHRQQQHENANSSWLQHWWNTLGYLQVRESVVINVSYFFHLADDPSATTLTQRGAALLTAAAQYRHQVCSGSLAPTVLGRGERAQPLCSAAYKYMFHASRIPRPQQDSYKIYDPARYRHAVVARKGHFYTLNLCGPDHATPYPVATLQAGLERIVAHADAMHAHPPPPQLGWLTTAPRDDWAAARQTLLDTDQQYQRSTVSDALERLESGAVLLCLDDVHAVSRLEMGQLLLHGAGHNRWFDKSVQLVVTENGKAGLIGEHSMMDGMPMVGLADHCTKVTYEQCLRKSPTGTMVPEPTVEPIFNTPEFTQILQDPIVHNLVDQGTCCVAKMDCDDWTGRHAMQSQSFQGYGSQFIKQAGFSPDAFVQMAMQLATYRLWGEQAGTYEATQVRPFRHGRTETTRTVSLESAAFVQRLGLRPQYNEHDAEVRGEKLRLLRDAVQAHVRYIGAAAQAQGVDRHFFGLSMLVADGEKAPDLYAHPAFVRAKRWRVSTSHLTHPKIVNWGYGEVVPDGVGLSYSIHPRHCVFNVTALKETGWAEKLCTLLEESLLELRTLIEMDQAPPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7G621</accession>
    <name>B7G621_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182648.1">
        <property type="nucleotide sequence ID" value="XM_002182612.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr48121"/>
    <dbReference type="GeneID" id="7203437"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48121"/>
    <dbReference type="HOGENOM" id="CLU_236361_0_0_1"/>
    <dbReference type="InParanoid" id="B7G621"/>
    <dbReference type="OrthoDB" id="48739at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1874" mass="208568" checksum="EB8C317A9EB95BD2" modified="2009-02-10" version="1">MEDSSPVEKNPNDKDDESFYKEGDVVLAVSREPRQHASREELDAPAPCASPGTKRTFTILAHPGMPAATMITGRAPVEKASVLSGLSFKMPDLATVPVSGLAIQGTTASPATFEPTKPPEGKPEIVPTATTVSHGIFDDADDEEDASMPLSTLKPNKSNSFLELQTQNFPMKNTAPMDVDEKVREAPRSDLMSIVLGKSPARKRVADSSPGPISLPIPELPPKSFEADVVEQPTKRRRKSATQKKLLVAKKERDAAQKLLCDKFDLRDFLPEEVCKFLGCNFWIFTVDQLRCVLKSSHDDEYLARQAKEIRKEIVELLKKKDGISSTGKGQNATGPMDHGENSTKTASTLPTTQITNRQQNHDGGNGTMEKDKAEQNKFENAGSVQAPDETVSLAGPNVEAESTLRGWLTMLPAGNESSATQVAKRFPLDGAISCLIPLNIRNFFASAGIKTLFEFLSIKKTETGSICDIEQMWRDQCNLKKMPAVALAKHLLGIGSRLEAAISTVPAVGKTDQKWMNDPIIVLTGAAHEFLVDRMGIKSGTNFLNMRTKDLSVQLVFWRNSKGLPPLKGSGKVAMISGWKASVKESIEVEQLPGKVLPFIDLTDLPPADLPEASSELRSEEPRGYSGAKHNVSKSSVVVMKEKLPVLNKQGKYALHSPLLLEEVLGKTLTSFLKSAGIDTAAKLFGAKRTPESLLGRAIRKSQIAVDADKAVTEWLDKIRAELKQFEPLPSPRQVRAKRAVEKTAKSVTDPFDALSALTKRFLTSMDISNAEQFLSARTTHIANEFVQFRTKEGMPDLKGLGAIASVSGWKAQCRKVAREMGLDAIGNIEPDAKSQVTPTLAAPNVASSKPNDYIDASMKRLPETKNLPFHPDVIFGAPRQPFSVQATQAMGNVRFLFHLSVRTEASSSQLGLFLCYDGASSGEVDVTENCAAIVDNIAGSQSSAIVLPVLRDGSSKVASTTEIVDHRFTFRTAKEGCGLIRLRKHGVRPFQDQDLSLLKEEIRSFLFSGNTDRPCEAPKYDPYNILLERDSLGKYDYLFCTDIFFEKGQMSRVQFISVSDFIRSRRHEESSQPSRPLIDAALYLISNKDLENAIIFVEEVLAETTDFNEAVDMMLASESNTERLTHFVAAARLRQRADWVFRRIVDAMSSNYRERKMATTRYKLYFGRRALLNHSKIKNLKPEILEQLRTTIATEMRNDFFSGIGLEGVYRQLRLSYWCPLAQSALDCLLDTIIGHFAMTDGANILFNVEEKLQLSFAKLLQEDPCVIHCLINQHGSSKQELDGRIVCVDQESEEARNTTLRTQVDVENGTSKICTHWYLNLLWQVAIVVISTFGNLYEDIEFRKDRIMKALKGVLEQRTDINESFGPTLDMLKFDVLVPLPLSDWKCFTPIPLSRQFFLGLVWPLLRKLGWRLDVGQTPDHVSFLAPFRNGHNAKKLKHAKHRMIQKRARLEKETNHNVGLGILSKSTKRICISTSIREEFAEIGSLRKVSTSKALDLFVEHVQDRSNEGNIFYNKQIEDVVNSIRVSFDELAPSLDSVRKTLDGLKPSESLGSEYLFQFLFILPSILRQSKIPMHQLDDAIEIVKELIAFLTNIYDVVLDEEFQPPKEVYAQDEDSSVSTLAARLSSKTEEGAERKGPIKSLTETVLEEDKPDLTDFMVVVLQQTIPIRATEEDMARKNRRVQVGFPGLGCRHCTGSGAGRYFFSSIDSVATAGTVIEKHVMKCGAIDAGIKAIVAEAKTRHTAQRKNHPQGLQQKFFNRLWDRLRNSKIGGESSGVYFFEKKDSADDAEHGEILSFSDHVAVLDYLHQSPRWREHGGDLLSAIHQYYNSLQYGSRVYGTSAMPPNFSSEWLLSKILPRKRVFNKAAMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6C4</accession>
    <name>B7G6C4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182549.1">
        <property type="nucleotide sequence ID" value="XM_002182513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6C4"/>
    <dbReference type="PaxDb" id="2850-Phatr48208"/>
    <dbReference type="GeneID" id="7203332"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48208"/>
    <dbReference type="eggNOG" id="ENOG502RXVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529445_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6C4"/>
    <dbReference type="OrthoDB" id="200051at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022017">
        <property type="entry name" value="BFA1-like_DUF3598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12204">
        <property type="entry name" value="DUF3598_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3598" evidence="1">
        <location>
            <begin position="164"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="515" mass="56675" checksum="C9DA7BF9D3A7721C" modified="2009-02-10" version="1">MYFPNCVTHDTTQQTSTRWANPILPFFTSHTQSTKENASRAITHRVDCNEIPKFRCSCCPSLCLEVNPILDTFLCFHDVYRPSSNKRFDRMKIQIPLLVIPLWISGTFAFSVPCPCPNAVATTANGLASTRCRSSKNIQSSFIALKATNGKDGSVSAQGDSAIQWELFHKHHLGDWKGIWTTYDYIGDVQDETVASVDIQATGGDKDDPTSTIVQTHNVVVGAKRSDCASCFDSMEIKSIPVASYKANDLRKARLAACSMINGPSLLRSGTMATELVLRHGDGRVRVVFQHAPVWAKDVEPGSCPPQGLKLFRAMVSREAQRATAPTAESEAANPPVEGNPVFYRPVPPFHWHKKWSGSSWTWGPQSGNRGWMMDEMEEVDAWHGSAPVECWNLRLPGGVFIQGPRIVTDANTELFRLAWLPDDGTLLRVEAGVLALQPMLVEDDMMVGFEPPSLASLRCDVLKKVGDLEGEPMFARITDYKQDGTVATDGSNASLNEDDDNSMGLQAIRDALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6J8</accession>
    <name>B7G6J8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_54879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182740.1">
        <property type="nucleotide sequence ID" value="XM_002182704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6J8"/>
    <dbReference type="PaxDb" id="2850-Phatr54879"/>
    <dbReference type="GeneID" id="7203395"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54879"/>
    <dbReference type="HOGENOM" id="CLU_2836748_0_0_1"/>
    <dbReference type="InParanoid" id="B7G6J8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="66" mass="7226" checksum="5A92F4F7D90352B2" modified="2009-02-10" version="1">MNPYRGIHQANQKMIQGSAGNDYFTSTYDIATEQIAKPSFYCDTGDLACIASSGHTCNLSQHCFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6W8</accession>
    <name>B7G6W8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plastid division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_48370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182929.1">
        <property type="nucleotide sequence ID" value="XM_002182893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6W8"/>
    <dbReference type="STRING" id="556484.B7G6W8"/>
    <dbReference type="PaxDb" id="2850-Phatr14995"/>
    <dbReference type="GeneID" id="7203577"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48370"/>
    <dbReference type="eggNOG" id="ENOG502QRFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_1"/>
    <dbReference type="InParanoid" id="B7G6W8"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="70257at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048285">
        <property type="term" value="P:organelle fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000001">
        <property type="entry name" value="Cell division protein FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855889" description="Plastid division protein FtsZ" evidence="5">
        <location>
            <begin position="27"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="302"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC45665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="44423" checksum="2879E8306E205A48" modified="2009-02-10" version="1">MKSPCRLLVLLSSSACLLLPITTTAGFVVRSAPSRSTTPGALAVASSDDHGDAPRRPQQPLVTSRKPHQLANGRGTFLGFRNVKDVPGLRSSNQPLMPDGGLSPCVIRVLGVGGGGCNAVDRMLETAVGGVEYWAINTDAQALGRSKALGANVLNIGSAVTRGLGAGGDPDVGRMAAEESAQDIAAMIQGTDLCFVTSGMGGGTGSGAAPVVSEIAKESGALTVAIVTKPFAFEGRRRMRQATDAIDRLRQHVDTVIIVSNNKLLEIIPDDTPVTAAFRVADDILRQGVVGISEIIVRPGLINVDFADVRSVMKDAGSALMGIGTGVGKTSAEDAAIAAISSPLLDEPVQDATGVVFNILGPRNLSLQEVNRAARVIYDNVHEDANVIFGALVDDDIEDEVSITVLATGFNQGRGPGVSKADVPDFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7N0</accession>
    <name>B7G7N0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183172.1">
        <property type="nucleotide sequence ID" value="XM_002183136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7N0"/>
    <dbReference type="PaxDb" id="2850-Phatr48552"/>
    <dbReference type="GeneID" id="7194720"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48552"/>
    <dbReference type="eggNOG" id="ENOG502QYAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358440_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7N0"/>
    <dbReference type="OrthoDB" id="45035at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="86510" checksum="B30B52668A9531CC" modified="2009-02-10" version="1">MEKNEKIEQIRNRRLRILASLALGCCLVGAVFVSFQGSDFFSDKPPSSSKPSLAKASDVAGPSESQLVAQVKELDQKVRDIKKTGVFLEVDPKGLEASRQLQDATRHLLARRYGSKEPYRVRVDLKFQESNPTYEANGEDGSFTIELAPSRLVPHSIFSFLEIARHWDDHKGAFHRRANHVLQVTVKGNQVPHLAFQEYSDLFPHVKGTVGYAGRPSGPAWYVSIMNNSNNHGPGSQQAANPHEADSCFGKVVEGFDDVVLKRITKMPGTGFLDKDKHVFIDKMTILVLDDTGKYVPWKQSGTLVHSDPHAVYAYIKPISLIGNDSLCHEASIDSNATIILIIRYYNVLFKVREKTGHKGRIFERAKKTTKSTGRRRRPKSKRGLKFQSTCVFDLMTVKRCLALPRDVFLAGAFIMKSANILTRLLLVWLQFTASSGAFAPARLGSTRTHRGSSCNSSSPPLVKSGGNWPNFLASFHQTDSNAKNNVVNQLVYQLAQESPNATYINECIPQLEELGKATVGVDENDSSRFERVIGLYNVSFVQTRQKDENPVGGRWTRSSGFAQKILRTRRTLQHVLPANDTGCARALMFQNRKVVAEAINVIVLEAFNGWIRTTILLRGDCVPLNTTERIQGTCQPLSPLAVRVWFDAPRIIIGRTGRFFNLNVGPQSSVVLDTPFVDERVRLGLGGRSGTRFVFARCDTQDTEATAFRTLLQRKPWSKVKTLSVLVGICGVGIYSAIGRAEKPILGGAISVFSALFAMLIAFSSGGIEQENISAKQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7S6</accession>
    <name>B7G7S6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_22554</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183068.1">
        <property type="nucleotide sequence ID" value="XM_002183032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7S6"/>
    <dbReference type="STRING" id="556484.B7G7S6"/>
    <dbReference type="PaxDb" id="2850-Phatr22554"/>
    <dbReference type="GeneID" id="7194745"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22554"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_1_0_1"/>
    <dbReference type="InParanoid" id="B7G7S6"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="235"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC45286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="419" mass="46405" checksum="6093EC48B18289F8" modified="2009-02-10" version="1" fragment="single">MTTDTAALSDTTNKPLQVVFLHLDLGIGGAEQLVLQLAHASASPHVGHEVHLVTTRCDPTHCFASVQPGGDLHDALHVKGQWIPADLCGYARAFCSTLRVLYLSFWIARRWPDVDLIVVDVLPTPLPFLRYLSHAALLFYCHFPDQLLVRQPSASGRVSQNHRALALAKHYYRQLLNAVEELSMRHADLCVVNSCFTQQTVRNTFPSSFPEPNPLPVLYPALDGAPSIVDLISSSSNKKKNLIVSLNRYERKKNLDLLIRAAAWLRQHNQPMPEAVANQTEQTHFEIVIAGGYDVRNVENVEYRAELEQLANQLNVPVTFLQSIDDGTRASLLAHALCVVYTPTGEHFGIVPLEAMYVGTPVVAVDDGGPKETIRHGVTGFLCQPTPADFGQALQTLLNDPEHAERMGRAGREHVRDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7T7</accession>
    <name>B7G7T7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_48596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183203.1">
        <property type="nucleotide sequence ID" value="XM_002183167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7T7"/>
    <dbReference type="PaxDb" id="2850-Phatr48596"/>
    <dbReference type="GeneID" id="7194751"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48596"/>
    <dbReference type="eggNOG" id="ENOG502QRYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579354_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7T7"/>
    <dbReference type="OMA" id="FWANFYI"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="50744" checksum="43DF5EEA89AA3E62" modified="2009-02-10" version="1">MSSSKGEACAPGGISLPSSTTVRVSLVVFAMFQITLAAGLIVGWAGIAGSMLAAPQSHGGAGISLDDATQLFGLAASINYIAPLLLGIVLDHRGPRSCSVLSNTLVATGCAVFAAAGDLRTYSMGIGLVAFGGPGVQTSLMHVGNLFPQRRFFVMGVVAETITLSFAVFPLMDILWETTGWTFRGLFGCLGLVVAMSALGSFLVWPDSPYEIQETVVLGLDRNPEGTIDKIEDAIEETLLTPADKDGKHSMNCLLDLPIQGQLTSGVFIRLSIFFLVTSFWANFYIATVTTELGDQQLFDFDTQHQLARLLSFIDAGAIVCAPVSGFLLDSVGFIPTAFITITLGIVQMALLMIAGSNENIMIASFVSYAIFRAFLFPYFFASLSKNWAFASSESYPEFPSAFQEFRNSQLHRWQIVSKELVTNTKTPSLATAAKTCQSTGDFAKTASHTGKFYFNLVRVYRGGELILAMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7U5</accession>
    <name>B7G7U5_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183075.1">
        <property type="nucleotide sequence ID" value="XM_002183039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7U5"/>
    <dbReference type="STRING" id="556484.B7G7U5"/>
    <dbReference type="PaxDb" id="2850-Phatr48603"/>
    <dbReference type="GeneID" id="7194872"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48603"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_5_1_1"/>
    <dbReference type="InParanoid" id="B7G7U5"/>
    <dbReference type="OrthoDB" id="47106at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="600" mass="66875" checksum="6D78A4DBF49942B3" modified="2009-02-10" version="1">MVLVVSNKKRVRMRMHRLLLAYGAFLLIAQHCFPNGVTSLSLQYTPTVATHRSRLSLANCDVQEDPESLGESKVVVVVGAGVAGLAAAWTLLQQPQQSTRGIATHSEFRDEKEHPLKVLVLEAKDRVGGRLWSVPMSQGTTTTKLGENANTSTVRQQQTNEATIVDLGGMYWHGDSPVLQHLQSCFPTFETVASGGTSQHPGRSGAQWLMYDENGNLQPLPLNEQAQIQVLYDRWDEHMCAEYATHRRQDRLLRKFMELDTPKLLSGWSQIFLEKLSVREQSLLQFQLDMAFGLDGGIPLAGHALRGLDSDWDWIQYKGEDRVSKQGMQHVMKELSDDIVAKGGTVQTEQRVTRIQYASSSLEYKVTITTESGTQYYADACIVALPLGVLKASSSVLFDPALPSRKQSTLDRAAVGALNTVAVRWNRPVCARNTTAYYLVGDKYPQNPLRNGYVCSGNLRGDDPTVTQFYLSETCFDFDDMTYWKTQALEIVQDLMPGEPKLALDDILDIKVSQWHLDPDIRGSYSAPATNTRGNMDRKRLAESVDRALFFAGEHTHYEGRYQSIDGAYETGVRAAAEVADALVDRLHHSRERGVNTAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8V4</accession>
    <name>B7G8V4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183657.1">
        <property type="nucleotide sequence ID" value="XM_002183621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8V4"/>
    <dbReference type="PaxDb" id="2850-Phatr48919"/>
    <dbReference type="GeneID" id="7195346"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48919"/>
    <dbReference type="HOGENOM" id="CLU_748995_0_0_1"/>
    <dbReference type="InParanoid" id="B7G8V4"/>
    <dbReference type="OrthoDB" id="53694at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="370" mass="40955" checksum="E19FFA7F87D063F5" modified="2009-02-10" version="1">MITTTETVASPEPASFLTTSGALTATPQNEECIKKRSPAEAAAAARRKRRRALVRRTHSPKNVPTRHCGSSSPLSPNRKPTLIQATVEGIREISVRWTRGDTVAIPTEYPGEWSERIRRLQGSDLCRCPHVLVPSSLDVPFLKKMLPPRPYAMRGKDGVANSVHAFSESQQVLQRLATRIWPGPVNIHVAVVDENADCSGLYSSRDGKKYLTLRSPGHPLAVKALLEQVRVDDSSVLVGLPLYHDSGAPCTAAMNVASRLFEEHDENNSRPWPSAVLNGEERREIFAVPTCEHGRVWPISLWIDASRRLVTIRGQDPGVNSTTMPLSPQNVMSSLYSTSHRRNSGLSDKSMKELLIQAVVRKWKVVEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8Y4</accession>
    <name>B7G8Y4_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHATRDRAFT_22873</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183547.1">
        <property type="nucleotide sequence ID" value="XM_002183511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8Y4"/>
    <dbReference type="FunCoup" id="B7G8Y4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G8Y4"/>
    <dbReference type="PaxDb" id="2850-Phatr22873"/>
    <dbReference type="GeneID" id="7195227"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22873"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="B7G8Y4"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="303" mass="32704" checksum="89F4F966C7CE7A6B" modified="2009-02-10" version="1">MSSSTEFLVNFMAGGVSGAVAKTATAPIERVKLLIQTQDANPKIISGEVARYTGIVDCFTRVTKEQGFKAFWRGNLTNIIRYFPTQAFNFAFKDTIKAMFPRADKNTEFAKFFLINMASGGLAGAGSLMIVYPLDYARTRLASDVGTGKQQFSGLMDCLKKTVASSGVGGLYNGIGVSVVGIIPYRGVYFGLFDTLSGYNPYQKDENGLLRAASKFACAQSSAICAGYASYPFDTVRRRLQMQSEKPKDMWVYKGTADCFTKIVAQEGAGALFKGAGANALRTVGAAMVLVLYSEITAAFNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B7G938</accession>
    <name>B7G938_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PGK</name>
        <name evidence="16" type="ORF">PHATRDRAFT_48983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 14"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183701.1">
        <property type="nucleotide sequence ID" value="XM_002183665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G938"/>
    <dbReference type="FunCoup" id="B7G938">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G938"/>
    <dbReference type="PaxDb" id="2850-Phatr48983"/>
    <dbReference type="GeneID" id="7195255"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48983"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="InParanoid" id="B7G938"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="448" mass="47486" checksum="B0E485AD538CD93F" modified="2009-02-10" version="1">MFRMLTSTALRRSPVTSSLTSCCKANAFAVRIRSFHAAPVIQAKMTVEQLAQQVDMKGTNVLVRVDLNAPLATDDVTVTDDTRLRAIVPTTKFLLEQGANVILCSHFGRPKGEIIETGKNGRLNPVVKPLEVLLGQTITKLDDCMGPDVEAATKNLGEGKVVLLENTRFYSGETKNDPELAAGLGKLADYFVMDAFGTAHRAHSSTAGVTTHMKFNAAGKLMEKELQYLQGAVEEPKRPMMAIVGGAKVSTKIPVIESLLDKCDVILIGGGMIFTFYKALGYDIGASLVEDDIVELASSLMKKAEEKGVKLILPVDVVLADKFDNDANSAVAKVTDISGDWMGLDIGPETIDLFRSEIAEANTIVWNGPMGVFEFSNFAAGTNDVAQMLAQATAERGAVTIIGGGDSVAAVNKAGLGDKVSHISTGGGASLELLEGKVLPGVAALTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9F5</accession>
    <name>B7G9F5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rad22</name>
        <name evidence="6" type="ORF">PHATRDRAFT_49083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183624.1">
        <property type="nucleotide sequence ID" value="XM_002183588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9F5"/>
    <dbReference type="STRING" id="556484.B7G9F5"/>
    <dbReference type="PaxDb" id="2850-Phatr49083"/>
    <dbReference type="GeneID" id="7195438"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49083"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554893_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9F5"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50452" checksum="12AC144D982320B6" modified="2009-02-10" version="1">MNPPAKVDPRGHADGNPNTSGDSHSSLLNTVNKTASSMDMDATMSAFSATEAYVQSTYQPPGAVYDNRMVNNSSSPHHNNKTPATAPRPVDYVRNPTDRSVLMDHHGRPITVDRLLATKPLQRELSTRPGPGNRKMLYLSGEGVTRTLNDIFGYDGWNLDIRKVTQVHQHQDTKTTRWNVSYMAHVRITHCRSGTYKEDMGAGDSTDKNVQTAIAHALKASITDALKRAARHFGDKLGNSLYQGTFTIHKAPKTLADALDQYDTERAHAKFGIVPRPTLPVQKASGGGRDHQSDMTKVHNSDAAQPSMSLVSTVNSAPEDAASVLKTPLHPSLRSVTPAPSGPWALSDLQQQQADGLVFAAAATPTLFPKEVTRSHGLFTCETSVPAIPHHPTNASTSSTASSWMSHEAHRPETATGSRHDGAGGGITTAQMTRSIVPSNATRFSESAQLPQQPPCKKAKANVNPYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9I8</accession>
    <name>B7G9I8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHATRDRAFT_49112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183642.1">
        <property type="nucleotide sequence ID" value="XM_002183606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9I8"/>
    <dbReference type="STRING" id="556484.B7G9I8"/>
    <dbReference type="PaxDb" id="2850-Phatr49112"/>
    <dbReference type="GeneID" id="7195335"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49112"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9I8"/>
    <dbReference type="OMA" id="MLPHGPD"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="494" mass="54086" checksum="1F1FB2B840777D8A" modified="2009-02-10" version="1">MSTATPHCHASTVEQDGLVYQTGLGNQFESECIPGALPRGRNNPRMVPFGLYTEQLSGTAFTAPRAENRRVWLYRIQPSVTIGAAESLPQEPQFAGGCDPRACEAAIDPLRWHPYPVDGAAGVEYDFVSGLKLQCHAGDPAMREGLAIYLYSFGTNMKDLQTHFVDHDGELLIMPQQGSLDVLTELGRLIVHPTELVVIPRGVVFQVNHFEGESKGPIPGTSPTATARGYMLEVYKGGFALPELGPIGSNGLANARDFLHPVAWCVAQSDYEKPCCIVAKMQSQLYAKSSTHSPYNVVAWHGNYSPYKYNLERFCAVNSVTYDHLDPSIYTVLSCQSEHVGTALADVVLFPPRVLATDANTLRPPWFHRNVMSEYMGLLYGSYDAKVSSGTDGAGGFVPGGSSLHNAMVPHGPDAATYVRAVADPCDAPVLLNRGLAFMFETYLPLRVNPQALRDEAWRDVDYTACWQDLTAADFTGWDWVNGTVGTTREEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9N0</accession>
    <name>B7G9N0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183802.1">
        <property type="nucleotide sequence ID" value="XM_002183766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9N0"/>
    <dbReference type="STRING" id="556484.B7G9N0"/>
    <dbReference type="PaxDb" id="2850-Phatr49146"/>
    <dbReference type="GeneID" id="7195614"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49146"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333874_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9N0"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="637"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="782"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="856" mass="93565" checksum="226B31F658C02276" modified="2009-02-10" version="1">MASSVSGKLKVLLFGTVGDETDALIEKVAALHGSKAGPFDAAFCVGPVNVARLLQNERTLTIPTYLQDDSLREEPNPSSPKSDWNHNAPEDCNQNFVPLAENLYLLRTPEHPAAANVWSLSVAPRKPALVVVACPARFRVDQTTVAQPLLDQLRHVSYTGCDLLLTTEAPQGMESIIGSESVTPSFPTPGSALAVSYDVAEVALLARARYHVVPSPNGLFQQSPAFAHLSATTHTTNTLHVGRVLTLGPVQPVTDWKIAPKTHKFVHALGLQPLHQQSITEQQGQRPAHVLTNPFTDTAYQRDGPPSTNGGHNSGLSEASARRILAEEQHKRSGGDPSQRWSSTGPHRPKRSRENDYQEQNVDLTCRTLFLHGLHKDVSGQLQSATGGDQVLLQALASFGAEQIRRPPQATTSSFCFCEFGTHDQALQCLQTLGGSLTVHGVLLTVKWATTVNAATGPDGSNPKRQRLTEPEARESSTIHYKLPPQMLNGPNSPSHETVAETLRTWMEHTLEYALASEDDTDHATPTVQAADEPALQVQKRLPSDEAMTFGFLDFASHAAASMALATLTGSTDGGRVTMENAKRVPEVFKSLWGGSAADTQPLYLNWARPKEADVHNIIEDASGFKFERRHFPADARKDCWFCLASEACEKHLITGVYQSCYAAMPKGPVHQGHVLLIPVKHSSQGALKDSIVAQEMDALKSKLRKHAYSVYDSDLFVFERAIQTKGGYHTHVQCVPVPKRSGIQLQSTMIAQARKTGMQLRELTSDLALAAMFTDEDNEGGYFYAEIPLAGTDFKRFLYKADGQGQTPLQFGREVIAAVLGKPSLAHWKSCLLDREEETAMASLFRESFEKFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9X6</accession>
    <name>B7G9X6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_23053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183853.1">
        <property type="nucleotide sequence ID" value="XM_002183817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9X6"/>
    <dbReference type="STRING" id="556484.B7G9X6"/>
    <dbReference type="PaxDb" id="2850-Phatr23053"/>
    <dbReference type="GeneID" id="7195532"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_23053"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="B7G9X6"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="265"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC44522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40368" checksum="3B5320449B764BB6" modified="2009-02-10" version="1">MTRTQCHYGSAEPTRTVDDGDTDTSTTSTPTRLNSESAPDGSEATLANRRRATIRERDSTYLWSSLAAGAGSGAVASVICAPLDLLRTRLQVWGDVHAKTDSGQMSIVRMIREMIAKEGYRGCFRGLGATLVTVPAFWGVYFPLYDETKRYWACRHPELNPALIHMGSAVLAGAVSDIICNPMFVVRTRLQTEALHQLDNHSNTGSRGAIKLSMIQTARGLYQDGGARIFWRGMSANLMGLSHVAVQFPVYEILKLKLAHTKKQPSAVDLLIASGLSKMTASLLTYPHEVIRSRMMDSRSASVRFTTTCRRIYAKEGMIGFYAGLPISLIRVIPNTCITFLTYEMFLRYAKDKIRKQRENERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN0</accession>
    <name>B7GAN0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_40162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184105.1">
        <property type="nucleotide sequence ID" value="XM_002184069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN0"/>
    <dbReference type="PaxDb" id="2850-Phatr40162"/>
    <dbReference type="GeneID" id="7195932"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40162"/>
    <dbReference type="eggNOG" id="KOG1108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1417675_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAN0"/>
    <dbReference type="OMA" id="RCIATET"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856028" description="Cytochrome b5 heme-binding domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="192" mass="21686" checksum="CC689920986AFC5C" modified="2009-02-10" version="1">MVQRSTTSISLLLLAISFVWRCIATETSLRVVTREELAVHDGKQNDALWLSILGEVYDVTAGKEYYGENGPYSVFVGKDGSVPFVTGTFTEEEAAKPLSVLEPQQMYGIENWRSFYETEEKYKYIGVLEGVLYDRDGNPTDELLRLRGVLAEAKVEAERREAARKEKIRQRRLKKEAAEQAAQNTASKNGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAN5</accession>
    <name>B7GAN5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_30365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184225.1">
        <property type="nucleotide sequence ID" value="XM_002184189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAN5"/>
    <dbReference type="SMR" id="B7GAN5"/>
    <dbReference type="FunCoup" id="B7GAN5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAN5"/>
    <dbReference type="PaxDb" id="2850-Phatr30365"/>
    <dbReference type="GeneID" id="7195815"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30365"/>
    <dbReference type="eggNOG" id="KOG1490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAN5"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="169"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="677" mass="76379" checksum="C5342A5D01635516" modified="2009-02-10" version="1">MPVYNFKGMKPVPTAPELVDIVLMRTQRRTPTVVHPGYKITRIRSFYMRKIKFTQQTISERLSGMLTDFPRLNDIHPFYADLCNTLYDRDHYKLALGQINTARSLVDSIARDMIRMVKYGDSLYRCKCLKRAALGRMCTVLKRQKASLAYLEEVRKHLSRLPALDPNTRTLLMCGLPNVGKSSFMNKITRGNVDVQPYAFTTKSLFVGHCDYKYLRWQVIDTPGILDHPLEERNTIEMQAIIALAHLTCSVLYFVDISEQCGYTIDQQCSLFRSIKPLFANKQLIVVVNKVDQQPWESLEEAKRAMVQGLADDANCSLMTMSNLSEHGVSDVKAAACDKLLATRVDARVSGKKIEGVMNRLQVFNPAPRDGVTRGAFIPDSDGVTDGDVDMDGGNIRKTARELMWEGGGPGVWAPDYRDQYDLADDSWKFDKIPEIIDGKNIADFVDADILDRLEALEREEEQLVAESDAARMGEEPESDLESEEEAAVEAIRARKKIIKEKKLATNTQNKPMLPLSIRGKSKDKHDAGTLLATEIRKTMDSIGVDSSKMLERGRLLERGRKRERSLSRSRRGADDEDAAMDVDVSGLSKAALKKIKKEKGEKARRDLSQARSHSRPREPSQMGLKDSESVKSAQKLDRLGRKGWMGASGEGDTRKSVHLVKWMNTGKKRNGTHYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBD1</accession>
    <name>B7GBD1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_49660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="CM000625">
        <property type="protein sequence ID" value="EEC44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184347.1">
        <property type="nucleotide sequence ID" value="XM_002184311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBD1"/>
    <dbReference type="FunCoup" id="B7GBD1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GBD1"/>
    <dbReference type="PaxDb" id="2850-Phatr49660"/>
    <dbReference type="GeneID" id="7198303"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49660"/>
    <dbReference type="eggNOG" id="KOG1759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129906_1_1_1"/>
    <dbReference type="InParanoid" id="B7GBD1"/>
    <dbReference type="OMA" id="YINFFDM"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="129" mass="13833" checksum="E9ED23529D01BE2A" modified="2009-02-10" version="1">MSVETRHPFCDLPGDPSLILTTNVDLGSKKLDILKAISKAMAEHTGKPEEYIAVSINDNADVIFAGSDAPTALGCMYSIGAIAMESNGKITASVSDLLEEYGVDAARIYINFFDMPRANVGWSKRTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBL9</accession>
    <name>B7GBL9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184549.1">
        <property type="nucleotide sequence ID" value="XM_002184513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBL9"/>
    <dbReference type="PaxDb" id="2850-Phatr40630"/>
    <dbReference type="GeneID" id="7198489"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40630"/>
    <dbReference type="HOGENOM" id="CLU_585915_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBL9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="101" mass="10778" checksum="1CBB8C21574E7C8C" modified="2009-02-10" version="1">MTVLSTGSRDGEHYLGCGTQGEPVETNLVCLATNPDTDGFGQAQSQLSIQKHDVTVSGLDCCHAKEHGNYDECAHGAVYNTVENSETDHDDAWQIVGPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBT3</accession>
    <name>B7GBT3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184502.1">
        <property type="nucleotide sequence ID" value="XM_002184466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBT3"/>
    <dbReference type="PaxDb" id="2850-Phatr49759"/>
    <dbReference type="GeneID" id="7198442"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49759"/>
    <dbReference type="HOGENOM" id="CLU_421803_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBT3"/>
    <dbReference type="OMA" id="EWICAVP"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="650" mass="67981" checksum="CA0FC2AB7F14998C" modified="2009-02-10" version="1">MLEGRIVTVNSKCGFIKTRCRSSENAGRKATGQGSSWPVYRLASCSESHHPCEISGGYHYLSLSLSLICARIAMVHFRFPRAHSVACWLLGAACLLATTDVSDAAVSITEHRHLRSLQEGTCPRETLVPSDEGQDCDMVDLVCPLETECPIWDGTACVDTVVESVCVCVDNVWSCNVPNCAPCDGQPSECPEENLQLSDMSGPCDITDDIVCPFDAGQCDVWDGQACVPQDIVTDCFCSGGMWTCALPSCVPCDPPTGATDVSCPEPELGENEGECAAEGLVCPLLAGECDAWNGQACVPEEVVTSCFCSAELEWICAVPRCPPCGPPITPTTECPGKPLQEADILGECDVPEGVSCPFNAGSCDVWDGKGCIAEDVITSCSCEGGEWICAMPGCAPCEPPIDSDSCPAELLQEADVNGPCDAEGLDCPFNAGQCEVWNGEACEMQDVTTSCFCEENEWICAVPDCVPCEPPTNAKPCPAEGLPSSAVSQPCKSEGSECPLNVNTCDVWNGTACVPQDTEAMCVCAELAWTCAIPDCVPCAAESLPGQSDLEPSGEPSVSPTGTVFPDTMPPSIVASDVDGEVPSNSPNGALDSSLSLLPTAVASTLDPTAVSETGSNIESFSSSSRKASYAKLLGTAVMALGWSLAICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GC71</accession>
    <name>B7GC71_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_16283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184668.1">
        <property type="nucleotide sequence ID" value="XM_002184632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GC71"/>
    <dbReference type="STRING" id="556484.B7GC71"/>
    <dbReference type="PaxDb" id="2850-Phatr16283"/>
    <dbReference type="GeneID" id="7198597"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16283"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GC71"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="249" mass="26839" checksum="7FC101295DA51FA1" modified="2009-02-10" version="1" fragment="single">SRIQAQLLVAADGSNSFVRNALQFPTEGFDYGQSALTFTVQLASPHHGRAFQRFLPSGPLALLPSFSPNHAVVVWSTSPEQAGSWKNQSDKNPKENLTKQLNELLQQGPAPPKVEAIVSPRFVFPLSCRQVTSYVQPRVALVGDAAHSVHPMAGQGLNLGLQDVANLADTIGQANSAGMDIATFLEDYNRSRLSQVSATLAGIHGLQQLFGAQQVWAKHAKSVGMNMIQNVPPLRQRLVQAACQGVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCD1</accession>
    <name>B7GCD1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000627">
        <property type="protein sequence ID" value="EEC43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184786.1">
        <property type="nucleotide sequence ID" value="XM_002184750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCD1"/>
    <dbReference type="PaxDb" id="2850-Phatr49935"/>
    <dbReference type="GeneID" id="7198632"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49935"/>
    <dbReference type="HOGENOM" id="CLU_485292_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCD1"/>
    <dbReference type="OrthoDB" id="49589at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="562" mass="63180" checksum="5FBE31392B8F825B" modified="2009-02-10" version="1">MKANHRQSLRQAPAALIANPGTRVDPPLSFHDNLLLIEIQSHTFSNTSLTIPFSLVWQREQEMRAAVDALQIPRDRWNGSLLYLRCCVQQQSHVMLNPERVCAEQNYSQLMAWHPWLTTLLERYYHTGRLTVPTNCLGYDFLLALEFFGIVYRPQQLVCKSLASYNCIQAWSEYFLYRTIAAEWVARDGLDEAPQSLRHVFGTTSATTPARSEAVQWGDIVLPTLLENVSDVVTPQQALGAFFNNETDMAMAEAMREDFALYLQSILTNAQVTFLIQSVTVTSARRARLKSRAILIVDAVQSSPPVPKSRFRYKKTVVDQNDWKRPYPSVRTESDPSFPYDEIAHEHAGEVERERTVETAQHNMNRGSSSPRHVMENVYDHIHEDLAYTVPATPVFIIADNNASNSKSGLPTNLLSRNGWAPMCTINVVRNCRSATKLGMSSSSGPFFVDGSGKLREVHDDNGQRSLSGIPNTGLLEKELEFPASETNDADQIRKDETKETTRKSSFDKWDWLTSMCSATYDTDSPSSLFKTKFGSEQETASAAGVPTKAGTQAYSFSRCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7GCM8</accession>
    <name>B7GCM8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_50019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000628">
        <property type="protein sequence ID" value="EEC43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184903.1">
        <property type="nucleotide sequence ID" value="XM_002184867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GCM8"/>
    <dbReference type="STRING" id="556484.B7GCM8"/>
    <dbReference type="PaxDb" id="2850-Phatr50019"/>
    <dbReference type="GeneID" id="7198717"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50019"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="InParanoid" id="B7GCM8"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="722" mass="81997" checksum="F39D00E37AE8B149" modified="2009-02-10" version="1">MKYGEHLKANIAPEYGEENYLHYERLDQIITQLTETKPSRAVETSRVVSMTAPPQTNAQGLDTSKINITEEDFLKLLESDMQKVEVFTLSQVTDLRHKILGTEALLKQTDGKGDPTWDPIVLEENADEIAEDFLRLEKYVNINFMGFHKILKKHDKRLPNLACKEFYVNRLHAQAWVRGDYSDVVVRLSNIYAALRNDNQAEENQDASQSFLRSTTKYWVKTEDVSRVKYAILRHLPVFLQKTSTGESDSQFTNSVYLDNDQLELYHGRLDKTPGAIALRLRWYGPGDPKLVFFERKTHNETWTGDVSVKERFTVDESEVQQVLTNTYPIAEKKQAMLESGTSQKEADEWETLVREITQVIVSKQLVPTMRTQCMRTAFQIPFDATVRVSLDTNLCMISERGYELEDMKVWHRDSSWVLEPNEIHRFPHAVLEIKLELGGGSLTPPKWVTDLQNSGFLYECHKYSKFVHGCAVLLPEDVRAVPYWIDDVSLRQSIVDSQAQRILADATVGVGPGANQVYNHLLPFGTTVNDRSLTAVGRTNADRNASKGLVGDKAPLLGAITTGANFYADEDGDDYGEDEEDISCWPFPFCSRQNYVLDGPLAPTSIQKIEPKVFFANERTFLHWLHHGVILSTIASGILSFSHETGAGWGQWYALALLPISLSFCVYAVHIFLWRADRIKTRIPGRWDDPWGPLMLGSTVAIVLFCNFIVKLVAISKMDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE44</accession>
    <name>B7GE44_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_50437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000632">
        <property type="protein sequence ID" value="EEC43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185370.1">
        <property type="nucleotide sequence ID" value="XM_002185334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE44"/>
    <dbReference type="SMR" id="B7GE44"/>
    <dbReference type="PaxDb" id="2850-Phatr50437"/>
    <dbReference type="GeneID" id="7199251"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50437"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109145_2_1_1"/>
    <dbReference type="InParanoid" id="B7GE44"/>
    <dbReference type="OMA" id="PYVKFEL"/>
    <dbReference type="OrthoDB" id="40528at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="139" mass="15720" checksum="B655928AC299DAEE" modified="2009-02-10" version="1">MGVFTVYLDRIANLRDSDTLGKSDPYVKFELEQDNFVFDKGFGKQISSKKKNDLNPEYGETFTFKGVPSMNNIVLHVKVMDDDIGFDDEIGSAKISMEKLGLTKVPKEIERVIDHKKGGGWFSRKAKIYLKVSFDEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEG2</accession>
    <name>B7GEG2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_1905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CM000633">
        <property type="protein sequence ID" value="EEC43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185516.1">
        <property type="nucleotide sequence ID" value="XM_002185480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEG2"/>
    <dbReference type="FunCoup" id="B7GEG2">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GEG2"/>
    <dbReference type="PaxDb" id="2850-Phatr1905"/>
    <dbReference type="GeneID" id="7199348"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_1905"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="InParanoid" id="B7GEG2"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="75"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="420" mass="47919" checksum="D12D59FC9EA90982" modified="2009-02-10" version="1" fragment="single">RMSNAEDLRPELDRRVKDVTEVLDVPEPAAMVLLSQYNWSKEELLEAYMANADKLLKAHGVYRRCGHALNPPSNRTKSCAICYDDDVDEMLAMPCGHEFCLDCWHDFSVAAIAEGPVCINTTCPHAGCPEKVTAIEFERSLGKQHVDYQKFLTYQIRSFVESNGLSRWCPGAGCERVACAVSAAAMESEGSVATCDTCATSFCLRCGQEPHAPASCPEIALWMEKCRNESETANWILANTKSCPKCMSRIEKNQGCNHMSCQRCKYEFCWICMGDWSEHGANTGGYYKCNKYDSDQPSSSGPVDQSDAAKAKRDLDRYLHYYKRYHAHSEAQAFARKQLKETEGRMVLLQESSDNGKWSDVEFLKTANEQLVECRRVLKYTYTFAYYLDPRLKMQRERFEHHQEMLERFTENLSELSERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEH1</accession>
    <name>B7GEH1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_31322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502QV8Y">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
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    </feature>
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        <location>
            <begin position="277"/>
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        </location>
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    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="313"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEI0</accession>
    <name>B7GEI0_PHATC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
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                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
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                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
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                <person name="Siaut M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
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                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002185454.1"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7GER1</accession>
    <name>B7GER1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRTGG domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50625</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000635">
        <property type="protein sequence ID" value="EEC42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185592.1">
        <property type="nucleotide sequence ID" value="XM_002185556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GER1"/>
    <dbReference type="STRING" id="556484.B7GER1"/>
    <dbReference type="PaxDb" id="2850-Phatr50625"/>
    <dbReference type="GeneID" id="7199472"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50625"/>
    <dbReference type="eggNOG" id="ENOG502RN67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GER1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DRTGG DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55949" checksum="44AE534A5C55B168" modified="2009-02-10" version="1">MMRNVAIMRKSHYCWRKAVTKHPGNAFSRYQGRSKSSDFHENPDDVHHNDSYRVGAWNKFPDGSRFWKKTTDGNFQRPIFVAATRQHVGKTTTSLALCSGLKKRYEKVGFLKPVGQQHVEVKSENRNATIRVDKDICLVKEHFKLDHIDYEHMSPVIVPRGYTKKFVDGEVSLHTQIDDVIDAMEHVSAASDVVLCEGTGHCAVGSIVGLNNAKVASLIGADMVLVANGGLGSAFDELNLNRILCQHYNVRVAGVIINKVIPDKHEQTKHYMRKALMQAWGVPLLGCIPDRPFLGCPALADLENLFQTQLISGEEHRFRHYNTSDINVVTTSLTRFLENLRHKQSRTLYICHVTHCPTEVIFNLLLLVLFLGDDLIVGFMGEYHRRREQSETPFEAALLVCGRKGKYQLSQEVTDMLRGLKGAPVMTVGLSTHDAMTAIHNYTPKLNIHDTNRVNVAVDHYEPYIDFDELIRRTQASNSNFNEPGSISMEELRTL</sequence>
</entry>
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    <accession>B7GET1</accession>
    <name>B7GET1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
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            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000635">
        <property type="protein sequence ID" value="EEC42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185613.1">
        <property type="nucleotide sequence ID" value="XM_002185577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GET1"/>
    <dbReference type="PaxDb" id="2850-Phatr50643"/>
    <dbReference type="GeneID" id="7199480"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50643"/>
    <dbReference type="HOGENOM" id="CLU_001650_12_1_1"/>
    <dbReference type="InParanoid" id="B7GET1"/>
    <dbReference type="OrthoDB" id="420989at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="724" mass="81051" checksum="8BDA71E483E5C060" modified="2009-02-10" version="1">MARVRKATGPTRKGATETVPEERVEEETPFEAVESPSKDSDNETQPSSMGDDNDSQSEIESYKIDTDIDFKYNPNFFEDKKALESVLRNTMGFGDIHVKSLQNEGLKTANDFLLISMSDINDLCDKLLFATVYRARLRAFATWLRSQPDNINITQEWTIPVMQLEMQMKAQASPFGTSETNKTDKSVSSLVPDPFDGTQKKWLAFRYSFEAWAGASGQSFDACISHDSERYSRSEPTATYNDINDEPDSFKYDWNVKSVRNSNIFFMLKSLTSGGDAWGLIEPYEVSKNGRHAWIALCAFYEGASQVGLTTEEARTTILTSKYTGQSRNFTFTKYVQKHLTGNNILARNKEAYTDSQKTNFFLRGIVDPELMAFKAAAEANLNEWKFERVVTYMRTQAAKLTSKDGKDSRNIRQATGLSKNRNNKNNRRKRSEYQSQGKGNKESGKGNNAPSTQLRKDIWDELSPEIKDAIKAAKRRASTDPRTAKRAKTSSTDNSNASVESYSPDLRSMSTEIFKADDDKDLASGQPEAKDTPLHLELEDTLKKPTYGAGTLFGRSADRVSFNRMVCSSEENKVTPWRMSELRLADATIRRICKNRTRNPTGRSTWGEAAIDTGADTICIGSGYTVLAHTGRYVSLRGFHDSGDTLDRIPVVTAATAYDYDDGTTVILVFHEALNLGPTQSTSLINLNQIRHAGHQTDDIPKFLSQGKSLHGIETIDGDYIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3K8</accession>
    <name>B7S3K8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999260">
        <property type="protein sequence ID" value="EEC42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176147.1">
        <property type="nucleotide sequence ID" value="XM_002176111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3K8"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1555"/>
    <dbReference type="GeneID" id="7205159"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1555"/>
    <dbReference type="eggNOG" id="ENOG502SDEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673492_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3K8"/>
    <dbReference type="OrthoDB" id="43034at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="452" mass="49702" checksum="05436A0E9B27E05B" modified="2009-02-10" version="1">MNAKKNRVEYVKASMQRMTVNKECPCLHHCASVQSNHATLQPSMFRSSSYHKGLCAICIQRALTEARERRQAALKANGRARVACAAVFEKSNTRKDLSQLQFESDQLRQKLDSRQKEGSRLALRVARMAMENEELQKSLVAQSATYTHRLRLERLQIALLHGGALTSAIRTATLKAQSLRWHWALQVFASHCLVVTPVEDDRRVLAEARRAHARGIGKIGGLPLPHAGPELYNVLPPQELVSALRLVASATKSVAQFLGIALPHPILLRQHIEGVTDIIELVMTEPETEPDRQLLSESMSESTNSLASIGKAAKHTLSRVVHRPNLIKATGSTKHTDVATAHSSPSGPLSMHPDLVNARLQHASSVVLVESATKGQDGTRYSLSSHTIHQEEFAISLQLLQNNIVALCIRAGVPVGRLWPAEAILLNLHALQIFCQEQIEVAILEDEGSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7S468</accession>
    <name>B7S468_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176348.1">
        <property type="nucleotide sequence ID" value="XM_002176312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S468"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1697"/>
    <dbReference type="GeneID" id="7205004"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1697"/>
    <dbReference type="eggNOG" id="ENOG502SN0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675282_0_0_1"/>
    <dbReference type="InParanoid" id="B7S468"/>
    <dbReference type="OrthoDB" id="40371at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="366" mass="41941" checksum="2833918C399E0451" modified="2009-02-10" version="1">MFSMLLHSPNKRPSSWLIPENKRHSSWAFRRELALQSQPGQPHHKGAHPDPDGAPHYPQPRQYDEGILGDLTGGRPGAIIETEEQLAIKAQILEEIDTKTRIYPAWMDQQYGALIEDEEAEFDIDDPDAIDSSTLGTWTIQDLRSKFDYEWDPNSGEPDPNMLEITRDDVRYVKENEKDEDGVEVGYNPMFGPSNPIDTRTILGTMDSYMIDDRSRDDTMLTPQFYEGDPEIGFNEDIVQFRKSLDIMETYIDPFLPDDMPIPRHVAKWHGYPEQTFLEPKNYTNNRFTEKPTDFDAMTPHRARQRAVELARSKNAEWLPDGVSQAWHTEQRQPYEDCGTLVGTLRKGEYSARVKGFGVVGGAALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4C3</accession>
    <name>B7S4C3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176369.1">
        <property type="nucleotide sequence ID" value="XM_002176333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4C3"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1444"/>
    <dbReference type="GeneID" id="7205075"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1444"/>
    <dbReference type="HOGENOM" id="CLU_825045_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4C3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="337" mass="39222" checksum="C94866FCA3E48622" modified="2009-02-10" version="1">MMQSTVRSQPQFCSKRWSEIDDPSKSNRARDKSLDQDDVGMKSLRKHSREDKTVSPLLLHARRTFDGPEHQSNVHWASPNYQKAFSSSRQKNLLTASIGLQNVFSTEHSEDSCGRNLAKAERKRRRKSRRAAVKIQAIARMKLARRKLAYLQLEKRMTEMGNCTRKDIRYVKAELRRRKRAYKEKAIARLQKQLTKDAKVEENQKLVLALKDDNTNIRASNVKISTNIQNLQVNNRRLDKTNTSGSELYEQLSLHHQKVKADNEKLTKINNDYKKKVEDLEKEVEERTHLCNLEQSIRDGYEQTIAAIVARIKRTDYQVLKEEVGGIIEVLNSQREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4C7</accession>
    <name>B7S4C7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176372.1">
        <property type="nucleotide sequence ID" value="XM_002176336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4C7"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1737"/>
    <dbReference type="GeneID" id="7205062"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1737"/>
    <dbReference type="HOGENOM" id="CLU_798028_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4C7"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002863386" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="348" mass="38305" checksum="BD13E07F2BCBC5D3" modified="2009-02-10" version="1">MYRFLTPVLLVIVMVLVITDNHDHTSPQQIEEVAVVEEERSSCDNSQPLFPSINSDASICLDILTDPTTGIAYHPPGTPPEGFIENPSRAPGQGASWIRIFPNSIGVLAALSNNIETQNLGVRDEDQCYYHGGHTRCSLSGIFISIDKDNNVSILSLGDEDERRLQTTQVFRSYFGSLGADTSTEDFETRVLFSEHGEDVLKLDQSMSQVLETPMWSTTDDYGGSGFKTTYSSSGISQTVTSFNLTTGVEDMVMRWYQRSTTAGQKDVEFSTTTSETFNIALTGQDVACEWTSGVTVLGWGLANACPGYVSNPTCVLISNLHWSCICDQSVETPFVWVNFHDTIAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4I6</accession>
    <name>B7S4I6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999292">
        <property type="protein sequence ID" value="EEC42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176476.1">
        <property type="nucleotide sequence ID" value="XM_002176440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4I6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1772"/>
    <dbReference type="GeneID" id="7205117"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1772"/>
    <dbReference type="HOGENOM" id="CLU_875690_0_0_1"/>
    <dbReference type="InParanoid" id="B7S4I6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="170" mass="19131" checksum="A9C431F84D5BC32F" modified="2009-02-10" version="1">MEHLDAGMDLVTLNRVHEFCMSHNTSRVGFVRTTGWPELSAAFASQERLEQTRVVANDKCWTNTDCDVCSPKTDSKSGNISTKIQRVVISSPSATHGEVNKETRGDKSSRKGLKKRAKQAQKGRSPLMWTASCAYINDIIHPNEFASRLSEDRWKDSQHFNHALPSSQKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0C0</accession>
    <name>RK12_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein bL12c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">50S ribosomal protein L12, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl12</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Plastid</location>
            <location>Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874395.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0C0"/>
    <dbReference type="SMR" id="A0T0C0"/>
    <dbReference type="FunCoup" id="A0T0C0">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="556484.A0T0C0"/>
    <dbReference type="GeneID" id="4524710"/>
    <dbReference type="InParanoid" id="A0T0C0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000276331" description="Large ribosomal subunit protein bL12c">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="128" mass="13451" checksum="1656B4FAF1E08B09" modified="2007-01-09" version="1">MSEKIDQIVEDLKTLTLLEASELVTKIEETFGVDASAAASGGVVMAAAPAVVEEVEEKTEFNLMLDEVPADKKIAVLKVVRSLTGLGLKEAKELVESAPKQIQEGLGKDAAEEAKKQIEAAGGKASLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0L9</accession>
    <name>PSAA_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem I P700 chlorophyll a apoprotein A1</fullName>
            <ecNumber evidence="1">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PSI-A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PsaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psaA</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>reduced [plastocyanin] + hnu + oxidized [2Fe-2S]-[ferredoxin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="1">P700 is a chlorophyll a/chlorophyll a' dimer, A0 is one or more chlorophyll a, A1 is one or both phylloquinones and FX is a shared 4Fe-4S iron-sulfur center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The eukaryotic PSI reaction center is composed of at least 11 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PsaA/PsaB family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="1"/>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874359.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0L9"/>
    <dbReference type="SMR" id="A0T0L9"/>
    <dbReference type="STRING" id="556484.A0T0L9"/>
    <dbReference type="GeneID" id="4524636"/>
    <dbReference type="InParanoid" id="A0T0L9"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1130.10">
        <property type="entry name" value="Photosystem I PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00458">
        <property type="entry name" value="PSI_PsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006243">
        <property type="entry name" value="PSI_PsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001280">
        <property type="entry name" value="PSI_PsaA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020586">
        <property type="entry name" value="PSI_PsaA/B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036408">
        <property type="entry name" value="PSI_PsaA/B_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01335">
        <property type="entry name" value="psaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN, OMPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128:SF19">
        <property type="entry name" value="PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00223">
        <property type="entry name" value="PsaA_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002905">
        <property type="entry name" value="PSI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00257">
        <property type="entry name" value="PHOTSYSPSAAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81558">
        <property type="entry name" value="Photosystem I subunits PsaA/PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00419">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0148">Chlorophyll</keyword>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0157">Chromophore</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0603">Photosystem I</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000275971" description="Photosystem I P700 chlorophyll a apoprotein A1">
        <location>
            <begin position="1"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=I" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=II" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=III" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=IV" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=V" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VI" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VII" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=VIII" evidence="1">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=IX" evidence="1">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=X" evidence="1">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=XI" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>chlorophyll a'</name>
            <dbReference type="ChEBI" id="CHEBI:189419"/>
            <label>A1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>A3</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>A3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>phylloquinone</name>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <label>A</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00458"/>
        </source>
    </evidence>
    <sequence length="752" mass="83596" checksum="A2FEB64333F4C252" modified="2007-01-09" version="1">MAISSTDRRSKNVQIFVEKDAVETSFAKWAQPGHFSRTLAKGPKTTTWIWNLHADAHDFDSQTSSLEEVSRKIFSAHFGQLSVIFLWISGMHFHGAYFSNYSAWLTDPVNIKQSSQVVWPIVGQEILNGDVGGNFQGIQTTSGWFQMWRAEGITSEVELYWIAIGGLAMSAIMLFAGWFHYHKAAPKLEWFQNAESMMNHHLAGLLGLGCLSWSGHQIHVALPINKLLDAGVAPQEIPLPHEFLINRELMSQLYPSFSKGLAPFFSGHWGEYSDFLTFKGGLNPVTGGLWLSDIAHHHLALAVLFIFAGHMYRTNWGIGHSMKEILEAHKGPFTGEGHKGLYEILTTSWHAQLAINLAMMGSLSIIVAHHMYAMPPYPYIATDYATQLSLFTHHMWIGGFCVTGGAAHAAIFMVRDYTPANNYNNLLDRVLRHRDSIIAHLNWVCIFLGCHAFGFYIHNDTMRALGRPQDMFSDKAIQLQPIFAQWIQNIHLLAPGTTAPNALATTSYAFGGEVVEVGGKIAMMPIQLGTADFMVHHIHAFTIHVTVLILLKGVLYARSSKLIPDKANLGFRFPCDGPGRGGTCQSSSWDHVFLGLFWMYNSISVVIFHFSWKMQSDVWGTISPDGSISHITGGNFAKGAITINGWLRDFLWSQASQVIQSYGSAASAYGLIFLGAHFIWAFSLMFLFSGRGYWQELIESIVWAHNKLNFAPAIQPRALSITQGRAVGLAHYLLGGIGTTWAFFLARAVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3E7</accession>
    <name>B5Y3E7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATR_46672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185831.1">
        <property type="nucleotide sequence ID" value="XM_002185795.1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3E7"/>
    <dbReference type="CAZy" id="GT49">
        <property type="family name" value="Glycosyltransferase Family 49"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr46672"/>
    <dbReference type="GeneID" id="7204410"/>
    <dbReference type="KEGG" id="pti:PHATR_46672"/>
    <dbReference type="eggNOG" id="KOG3765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y3E7"/>
    <dbReference type="OrthoDB" id="205012at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACI65301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1347" mass="151847" checksum="98D775A390FA3566" modified="2008-11-25" version="1">MLQNIVYLPLHSFFDKNPRYDWLACKKAHNNLTPNLIATMSISIEHEDNTFKQGEHVEENIVDVYDDEEEVISNSGCGVLGRDDTKEKVINWVGLIGDLFIRSLKCVVLPLVFINVIISVVDMMTIGRAGSIGWKTIGLYLTTTVIASILGILSILSFKPLFEEGTFTASSPATIKLGCNDSGEYKTELQDGTLTCTADTGNSSQFFIEDLSQSFVRASGSVRSDISLSDTIYEGVFTNRLWRLISRPFAIAFSVALSKVFDRQRDHDTSFIIPFLKELDSVFLTIINWIIMCTPFAVLSLIASAIGKQEDLADSFANVGYLVVATITAMALQIAVVHCLIFGLVTRSNPWHYLKYMIPAQTMAFACSSSAATIPMTLKCVQSTNRVPEPVARFVIPLGATVNMDGGAIYFPCACIWLAVLNGIDPDIASYFLLVIISTIGSAGTAPVPSASLVLIITAYNTVFNTTGVPEGFSYILAIDWFMDRLRTVVNVTGDTVVAGMVSHLCPDGLHETKTRHDSSVEDEPSTDEEVAKRLPSMPLFGFRKQRKASRSPSPTRGAASSSTASRANTGTTRPLRSRRTHVDSDERMHNPLGSPMLLPTNYDPDGRLGQNAYQTSPSMNTCNNFLLGGNYYPGKDKKRRHYRTKAIWYRIFCSSGPRQIVTFIVSLYLFLWLPITHLLSTSQAPSLTNFDWLLRDTTLQLPTMEEQRDTASKLNIERDQLDAEGGISDRLRILEKIVPDWFHRNDEQPLAKPDVPVSSKTETQPIPTGDRIPQPRKDVDSEHIVEDRPPENDGKVHSRKARITRMKESNKDGVEKGNELANPKALEPYGGPALVVRKAGDRIRHLGNTDLFVNETKCPANLIPDDVQTTLVIQSSSNRLWILAETCKRWNDPIIAVIALTSTEDHDEVSALLSGWDDKCPHLQVIVYQMDTDEEKPEMYPVNRLRNIGLDAVHTSHVLVADVDFIPAQDLARLIRTTLLDRARLRVLKDDMIPKDQDAIVVPAFERLLAEPCTSEDSCKEHLRSNSSFIPHTFDDLRSCIAEKSCIVFQSKVNWEGHFSTHSEDWLKKKWYQGEPIAFGEGKPSVRHIRTLDCFDSLRYEPYVVLQWCPTGKPDPVRATAPYYDERFHGYGKNKIQYIQHLRLAGYHFAVLPEGFIVHNPHRDSKAKETWNNQIVWQRYFATSLLKRVDLSLRNLSQNRIQCSANDWITDRHFDLKVYFALCVFETIYRTERPLTPQRIEHFAFDTLRFHSPALRNHVHPRNRQQWFGCRTDASSLGNEKATCYLYGKEIHPKHAKDSRFHPSGMFTLFGSAGKLIQRSIRTNSGLLDYDVMKGWDEFRTISRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3H1</accession>
    <name>B5Y3H1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_46692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185653.1">
        <property type="nucleotide sequence ID" value="XM_002185617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3H1"/>
    <dbReference type="PaxDb" id="2850-Phatr46692"/>
    <dbReference type="GeneID" id="7204492"/>
    <dbReference type="KEGG" id="pti:PHATR_46692"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="InParanoid" id="B5Y3H1"/>
    <dbReference type="OMA" id="ESFPTRY"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACI65123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="566" mass="61363" checksum="4DF884146BD38E2B" modified="2008-11-25" version="1">MTDLLQLGNIVDSLQQPLLASKDCVLDRWIMALQEEEQLGIEANDEDSMLSNTIRELDGLDRVQDSTNVSMSLESNHWYSNDMLIIAMLSNFSTSYNVVNISLVLPILQQVTNTSSTKDAASVASSLLAGMMFGQVFGGALGDYPRLGRLGALRLVMCLQLVASLGSAFVDTSGTAILDVYDQLTLWRFLLGVGAGGVYPLAAVLSAEQGESTDAESLHRVVLTFSMQGVGFLTVPLLTVPLLYTVSNLNTVWRIILGLGSLPGFALLLLQWHWYRKQQTGEILPASDPEQDAAFGQESSALQDSDGEVGTCLDSSPNLENDSGSESTQIVIRHGWLGSIRHEDHLFSKLMGTAGAWFLFDVLFYGNTLFQPIVLEAAFGTPETSNARQLLQRTALNSLFLTSIAFPGYAIADLVMGKKTLGVTQTPRYVMMQGFTAMFLLYLTIGVFWRGLKHYPVVLVTLYGLTFFFANYGPNTTTFVLPSLVYSVECRSTLNGISAAAGKLGAWTGATLFAPAASRYGNATVMIMCAVVSVVALALTKLFVKVKAPHGHHHANHSAISPEEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3M1</accession>
    <name>B5Y3M1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATR_46737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185861.1">
        <property type="nucleotide sequence ID" value="XM_002185825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3M1"/>
    <dbReference type="STRING" id="556484.B5Y3M1"/>
    <dbReference type="PaxDb" id="2850-Phatr46737"/>
    <dbReference type="GeneID" id="7204635"/>
    <dbReference type="KEGG" id="pti:PHATR_46737"/>
    <dbReference type="eggNOG" id="ENOG502SET8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y3M1"/>
    <dbReference type="OrthoDB" id="49226at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VASt" evidence="4">
        <location>
            <begin position="458"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACI65331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="662" mass="74363" checksum="CEC58588EC3DCFB0" modified="2008-11-25" version="1">MPVDIHRWNLMERWNRGILGCFSHTVELAGGSSSFRHFSKLDRICRIKLFVVIELHIRGFEEEAEGFKSFGSTTSSPTLQPTFLSTNSDADLTAAAGSLHSEYVCVYNGLNGTLYAGDKALYFVGTFFFFDKKVTLPWEEVRQVQMISQGVQILCKDESVTQFTGMHHPDRVWTILVSLHNDALLDLPLQQHQSVTPRYGGVKRRSSDPMLMSNSDLEAFFEDDNVDEDNDAKRVEEFSKLREKVAFAVDCKTNLQKQTIKRSTTTPPASPSTKVSQSAEQSEVEYAIGQIRLQPIHCRLYAGNGGLLFYGRRFFFDTQIVTIKFPSIQQVQIIESLSDQSDRQSSGVTILTKEGVRHKFDGMDNADKVWASLVTLHNENLTTQTPGRQRRASQLRRTNSDPALTSGPTFDIDSIDGYQNKYLKPSTAHTDPPLVTSEHMGIETTAKEDWSDVSKQADYKNVVVKDHVLTNCSLGKFYDLFLAEGAPYSMAKFLEARGDTELKVSDWKSAKDSQKWRTRVINYSHPVNAPLAPPKAGARKEQRFRRFDEFGMIVQTKTFVDDVPMADCFYVTDRIRVEPAGTDAVSVFLEFEITFVKSTMFKSIISKTTASEFTNSFRELAKFMSGALGETATVEIEKPPAPIGDKGDSSHRAMFNPSGLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y3T8</accession>
    <name>B5Y3T8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATR_13360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185896.1">
        <property type="nucleotide sequence ID" value="XM_002185860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y3T8"/>
    <dbReference type="FunCoup" id="B5Y3T8">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y3T8"/>
    <dbReference type="PaxDb" id="2850-Phatr13360"/>
    <dbReference type="GeneID" id="7204667"/>
    <dbReference type="KEGG" id="pti:PHATR_13360"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_1_1_1"/>
    <dbReference type="InParanoid" id="B5Y3T8"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACI65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="226" mass="25294" checksum="DC88FFDFBAE728A7" modified="2008-11-25" version="1">MASAILQPNNTLYVKNLDWKVKKNLLKRALYALFTRYGKVLEVVALRKDGLRGQAFVIFEDVQAATAALQALQGFPFFGKDVALEYARETSDRIAKRDGSYVPKARRIKKALDQNETDSSEANKQDNHQAKEESAVAPPEGDMPSPQDTAPPSKYLLAQNLPSDCNEMMLGMLFRQYSGYKEVRMPRPGLAFIEFEDEPHATLARNALNGFKLTTSESLQLGYGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y415</accession>
    <name>B5Y415_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATR_13294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185927.1">
        <property type="nucleotide sequence ID" value="XM_002185891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y415"/>
    <dbReference type="STRING" id="556484.B5Y415"/>
    <dbReference type="PaxDb" id="2850-Phatr13294"/>
    <dbReference type="GeneID" id="7204425"/>
    <dbReference type="KEGG" id="pti:PHATR_13294"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_1_1"/>
    <dbReference type="InParanoid" id="B5Y415"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACI65397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="193" mass="21497" checksum="A8DA0D028A6931E3" modified="2008-11-25" version="1" fragment="single">VLLGLAEASRTSQSLFIVHRLDCETSGVLLFARTSEAASRLSRAWREREHVQKTYVAKVYSWRLPETSGRIDLALAPHPTERIKWIASKEGKPSTTLWTVMPDERKATCQNPDSDGCARPVKLRLIPVTGRTHQLRIHCCAHGDGILGDTLYGKFATQSLPGKRSRLFLHSQALSVPHPTTGKMVTFISTPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4I1</accession>
    <name>B5Y4I1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATR_43841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186014.1">
        <property type="nucleotide sequence ID" value="XM_002185978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4I1"/>
    <dbReference type="PaxDb" id="2850-Phatr43841"/>
    <dbReference type="GeneID" id="7204273"/>
    <dbReference type="KEGG" id="pti:PHATR_43841"/>
    <dbReference type="eggNOG" id="ENOG502RU2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063571_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4I1"/>
    <dbReference type="OrthoDB" id="42859at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACI65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="373" mass="41174" checksum="9B6B77B43E960412" modified="2008-11-25" version="1">MGAASTKYGVCPQAAFHIRVQIDQFESKWLTSECRHRRSPLADDWTPPGKTTAAREQKTPRQAQRNRATGNVSTMFRAVTSSAARRTAQKLSSSSSRGLPGCAVPRVEFHASAKREEDAKATPAPVEEKKGFWDPSYSIPLGIALAVPVLKYEWYIVNEETQLAACMMAFSLIVYKQFGGVIYEALEQDGKRILAEHNAVEDEDIAALEFKINDVKAQSQIVQDAEDIKALKIQTYQKLNEVGKIKPQYEFKSQIEKLLSLMATEEANMTEKAKAALMLEATDAVKADFATSKELKKSSLQGAIATLKGAADKSDPVKDAYLKFFRAKAKSTVDEKAEAAAAREQMITKLNAVARSEGFFFEFDASGKPKMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4P8</accession>
    <name>B5Y4P8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATR_43897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186048.1">
        <property type="nucleotide sequence ID" value="XM_002186012.1"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr43897"/>
    <dbReference type="GeneID" id="7204306"/>
    <dbReference type="KEGG" id="pti:PHATR_43897"/>
    <dbReference type="eggNOG" id="ENOG502SZGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B5Y4P8"/>
    <dbReference type="OrthoDB" id="57518at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019960">
        <property type="entry name" value="T1SS_VCA0849"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03661">
        <property type="entry name" value="T1SS_VCA0849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838790" evidence="1">
        <location>
            <begin position="23"/>
            <end position="2125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACI65518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="2125" mass="226563" checksum="FCD0D935DAF12798" modified="2008-11-25" version="1">MTVRLCLQLYLWLLGCTARSLSQKLRGNPWMGVVEPSFRTNSGRRLGSFEWEIDLLDGFPFLNNITDTKQIEFSYWFTGNASLPGRSFDIVLLEKDCRTASVVSPQGRGLFLDSEEIYDQGIDVIVGVDLTSIASSSFYNRTSQLSAAIEFCLRVDYQSAGESVNFHETTVSVSVDLTAGFRLQSISTERNEEAVVSESVACEVNAYFCDDSYTDTGTPRLAQGDVFQACIASTGQFVIKDIVSAQLDQGQDNQTTGVRDDLAIDYEVVDPLTVISCSLGRCNIKTQMRTKYFSENNPISVRLSGLALCGFGSTPAAYCASSVKPVIGENSEFLIYPVALSLHDYDNSDEYESVVISWSTQGTSAEPFVEFAVAPPGVSITLANRELTLRGNAQDIEDAVANLKVRPGQDNGEDIDIRVKATAMDRNGLMATAECGFRIPVDPFVFGILRLDSPFPSDISIRAFEDTAIELSGISIEFSGYDTDGSEVAYIEIEASSIPEGSVLLSNGIVQTTIVDGFLRLPMEAGSSLKIKPPRNYSGEITLSVRGAITDACIRISQYTVSNSVLVATIPQKLSIQVEPVADAIMWTTVYAIEDNGAVPFGAILANRQSGIRLNDIAQGKGNNPEPETILQIVISVPPDSNEVTYLVSGTFVPQSDGIVTGEGTGVVSFDLQRRTFTIRSSLLTNRVNLAAADQETREQADKDIRATLAAFYVEIGPTHTDIDGDLSVTVTTLDVQMGFFDTTDVTFKPIKLQAVADQPSITVQSAAQIVSEDGDLVPLYFTVGRSADEDGSENLKVLISVPLDELGPIGSITGSLPVGVLVINEGPGLYLISSSATTPIGQETSLNQLFDGQIKFHPRNNFSGQYLGSNGIRVDVFMEERATNDQLAPVEYGLDGDSKLAKATGFIDIFVLPDADKATVLVKGNAAGMEDKPIPVPLSVTLGDLDGSESYSMEIVDNLPAGAKLLGSTSRELLSEDGVFFLFPIDVESLILLPPLHWSSAKQGDIVLLTNTTTVDISPQSSSSASVYLSIPIKIVGVADKPNTRPVVVHCLEDGTYNLGSSIGDLSGVLVDVSILIRIIVVKKGSPNLLCSFSIQTDGSEVLSLVLSGLPLGVVPQSEESNIQYLGKGRWQVPETAIPSLTLPALPNFSGDNPYTGITINAVSQELDRDQAVSDSWPVTIKVRPVVDGFASWSMSFTTTEGMNEANNGGIDFKSVKNFVLGDEDNSEAVISFTFDFSNLMVNAGIRTRLNQLEGQSAGLEELVSKRMDGEFTFDQESGTVLVLSENIENIKLHSELFLDSNQNFEIPVNALVRDSAVSDGSSVREDKIKSGVLFVIISGTADIPTVFAEPTISGSVGESGIPVRLGGETTDRDVSLGRTQSEDVYYLVSTSSSSISNLFTFSGAGLNNGDGHWTLEKSDLAGLQVYFSPSIGMRNQSEASFDLTAVAVEDDGDWAVNTTTFKVILQPNEAGDTMTIPPLPPLLAIGLNAGLEDTKISLGSISAVVNPDDPTNTTISVAIWSIPPNAKVFGARLNPTTGKWICSAASINSGAVQILPGPDYSGSLMLTIQAIATNHYALSAHSPEQKLEFIVDPVADGAAISISPSSGLEDEMVSLRVSLTELDVDGSERIGHFAYIKMTNGATLIGNYTVVTEYDNDAFIGTFSNAYSLRVPSEEISELSLKPAANWHGTITLEISVPVVERFDDEDGDHVKVARKTHSIEISALADMPDISVPSVTTIGDEDTEIAIAFLAASLTDTIIANGREILSVVISNVPESSTFNSGYNNGDGSWAIPTAALDGLSLLPPEHFAGTVKLTLTAYALELENGSENSQSGDFDINVRPVADPFLMVATSISLQASSGTVDIALNLRLQDTRGDSPGEIPPEIVQLEFQNLPRGIYLRASQGGGVVTTPAGTFVFAGSQAQANALRLLARNATEGTYQIAISGVTVDGDSILSPAVRDSFRLTISPSNQTLPGVELIGTNGADNLTGSIGHDILMGLEGADLMRGGDGMDWLAGGPGADVLTGGNGADVFSWSSLDLDGSVDRITDFAVGQDQLDLVSALNGYNQQLSDISSFLSVTTSNNDAVIWIDIQGGGNFSRFVLLENLAGVSLNELVSNGSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y4Y3</accession>
    <name>B5Y4Y3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATR_33313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186087.1">
        <property type="nucleotide sequence ID" value="XM_002186051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y4Y3"/>
    <dbReference type="PaxDb" id="2850-Phatr33313"/>
    <dbReference type="GeneID" id="7204190"/>
    <dbReference type="KEGG" id="pti:PHATR_33313"/>
    <dbReference type="HOGENOM" id="CLU_1269068_0_0_1"/>
    <dbReference type="InParanoid" id="B5Y4Y3"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACI65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24515" checksum="2B1E3E4947FB1185" modified="2008-11-25" version="1">MGGEHLQCCYREQLAYSLYARFREPKLFRMAVDGNWDTIPERCLSHPREAAFLHKYAPYDTALHRVLRPTESECSFREDLDDDMKIEIDGIKFAAVRALLLANPEAASIQDAFGRTPLHLACIDSEACCVASASLIVKSNPQACLILDVEKRTPLHFLLARNDTISPEFLELLVAHGANAVYLKDAVGESAIDIVRRRHDKIKNSKHVLDILKRVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNU8</accession>
    <name>B7FNU8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_42590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176598.1">
        <property type="nucleotide sequence ID" value="XM_002176562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNU8"/>
    <dbReference type="PaxDb" id="2850-Phatr42590"/>
    <dbReference type="GeneID" id="7195963"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42590"/>
    <dbReference type="eggNOG" id="ENOG502SI70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030622_0_0_1"/>
    <dbReference type="InParanoid" id="B7FNU8"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855123" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="307"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="634" mass="70564" checksum="05ECC865599E94C4" modified="2009-02-10" version="1">MRFPILTTIVIASLGWNHQACTKAEETNASEAETCGLYLAVSSTSTAEETNWGLYSGRDLAPRVSVGFPDVGINMINLRAHGVPTDAENDRNTLLSRTVDFLESFVWVPDPAGAKFEVQNGKIITAIAGAGVLGGFNVKLTNANWKHSAAYRRPRLEHENDVEKNHPGRGASTPFYNVMLESSTEISQGSEIFVDYGDNWEDEDKEHELTKDEYKKLDETVVKMVNFFEKHKEELDADSKQEIFQFLMQDVLSAAIGPDKAHKVGTLLPTVPDELPRVVEAGGSLAYSDPTIYRKLEWLDEHGRCMDNIKAGASNISYAGRGAMATRAIKQGSLVAPVPLIQVPDRAVFNMYNLQLSEDGETYIRTSDDIVGEQMIINYSFGHKDSSLVFVPAGAIVNLINHGDTPNAKMVWSTHPSHRKMWLNFKPETLLDDEQMYTGLLMEIVATRDIEPGEEILLDYGPEWKAAWDAHVESWKGRLAKGEISETRAPTAVDLNTKYSEQPYPSESEFAAPENVCLKASLSVEESDATGTLENPKTWATPDEFANLNPDTLVNMHVVESRKVEDEEDGDEPFRYVVKWANNNGELTFVKEVPHSAIAFVDMPGMSDAFTEGAFRHVIGIPDDIFPKAWRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP04</accession>
    <name>B7FP04_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_3171</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177133.1">
        <property type="nucleotide sequence ID" value="XM_002177097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP04"/>
    <dbReference type="STRING" id="556484.B7FP04"/>
    <dbReference type="PaxDb" id="2850-Phatr3171"/>
    <dbReference type="GeneID" id="7195994"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3171"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648079_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP04"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC51596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="220" mass="25401" checksum="7F310271941067DA" modified="2009-02-10" version="1" fragment="single">PLAKPAHEKLLPDWSQLPNVPQDIPVPHTLVLDLENTLVSSTWDRRYGWRHAKRPGVDKFLRELAQYYEIVLYSPSIDGIADPVVTSLDKDGCIMHRLYREATYYTGGVHVKDLNRLNRPLNRMVVIDDDPSEVQFNPENLIRVKPYADPTDRTDNTLERILPFLVEIAREGYNDVPGLLRQYEGMDADQIADEQDRRIHELRTHRERRSQQGLGALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP16</accession>
    <name>B7FP16_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_42645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176630.1">
        <property type="nucleotide sequence ID" value="XM_002176594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP16"/>
    <dbReference type="PaxDb" id="2850-Phatr42645"/>
    <dbReference type="GeneID" id="7195999"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42645"/>
    <dbReference type="HOGENOM" id="CLU_886985_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP16"/>
    <dbReference type="OrthoDB" id="10469073at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="314" mass="35227" checksum="C011CC77D21A2E6B" modified="2009-02-10" version="1">MMSKKSITLINMNPPYEMKATTLMMAAPHCTTGVQQVLVYETEIRIRDLVAGAAVETNKPLSVASFDAIYADSHTVVIPDAMFTEKSKVFKSEAFVKHGMEALGSFQKAGGNVIVFCVEGTLVIGDTLNRLFGTKWKIKFFESAAVEATDLAMATFGRFLPMQAHLKDGSYFIDCPNKEGLYRRIMNDKKTFEENFHAEDATFEKLGIEKDETMDCFNIEKSWENYVSKYTNRYCIALHQGRYMEGHVVWYGDRGQSDTMAYLFCKMLNLGSVSPDPSDTVKTKSKEKNGLDLAILLPLVAIIVAVLTRYITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP49</accession>
    <name>B7FP49_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Sec23</name>
        <name evidence="16" type="ORF">PHATRDRAFT_42673</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPII-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177155.1">
        <property type="nucleotide sequence ID" value="XM_002177119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP49"/>
    <dbReference type="SMR" id="B7FP49"/>
    <dbReference type="FunCoup" id="B7FP49">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FP49"/>
    <dbReference type="PaxDb" id="2850-Phatr42673"/>
    <dbReference type="GeneID" id="7196326"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42673"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7FP49"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000014">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="130"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="413"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="516"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="630"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEC51618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="759" mass="83944" checksum="96A8218FBD2D9502" modified="2009-02-10" version="1">MEGSWDVTASEEMSGTRLSFHCWPSSRLEATRSVAPFGALYTPLKKLPPQCAPQTTLPYDPIRCSCHAVLNPYCQVDFRSKLWVCPFCLQRNHFPPHYADNISETNLPAELIPQYATCEYELQTVPDQGPPCFLFVIDTCAQKEEISELSDSLQQALNLLPTDALVGLITFGTNVSVYDLSSDSIAKSYIFRGNREYSPGRVGELLGCNRHPGQQSQPNGQTSMGGPGQEVLERFLLPVSECSFVVESILDDLRCDPWPVPNDKRPARATGCALSVATSLLHLAIPRRGARIMLFTSGPCTSGPGAIVSRMKGEDMRSHADLAKNVEPLHKPACEFYNKAPIPTNAPHHAVDVFACSLDQVGLLEMSELVEATGGLTVLGDSFGQSVFKESLRRVFNRFPEEVPQDGGQLQMAFNASLEVLTSSEFKVSGAIGPVTSLHKAAPNVSEIEVGKGGTNAWGLGGVDPNTTVAIYFDVSNPGTTPLPEGKRRFIQFLTKYQHANGRTRLRATTLCGSFDQEAAAVLTARMAVHQTESDEVADVLRWVDRSLIRLCAKFAEYEPDDLNSFRLSPEFSLYPQFMFHLRRSQFLQLFNSSPDEAAYYRYILSRENTTNSLVMLQPTLLSYSFNGPPEAALLDSESVRADTILLLDTFFHVVVFHGETIAAWREQGYHEQDEHAAFRALLEAPQSDAQLIMDARFPVPRYIVCDQHKSEARFLMAKLNPSVTHNSNLDGSGSAQVNTDDVSLRVFMEHLMKLAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP56</accession>
    <name>B7FP56_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_53967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177157.1">
        <property type="nucleotide sequence ID" value="XM_002177121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP56"/>
    <dbReference type="PaxDb" id="2850-Phatr53967"/>
    <dbReference type="GeneID" id="7196331"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_53967"/>
    <dbReference type="eggNOG" id="ENOG502SNYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1126363_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP56"/>
    <dbReference type="OrthoDB" id="193290at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852488" evidence="2">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="247" mass="28283" checksum="52895F0EB07F140E" modified="2009-02-10" version="1">MKSRSSTASIFLYVVTLCGLMFDVTSYSPKSPVTTKPNFSPRAPRNSNAAGEEVSVHRILAEERRKQWIDQSLHYYTKVMREERRRTLGQAKNFNSADYQDDFMLLAKKHYFALRKIKDGKPGHAETIYRRVIDELSADDEHCDHAKLAVTTLLLALLLQRLGDIKQTRSVFLNFFRIAVLESAKDEECACSAKVLQAYALFEMKQGHSLKSLDIVCKAVKLDPSLAPVLRWKQFRDALERRAVQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQ05</accession>
    <name>B7FQ05_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_32027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177306.1">
        <property type="nucleotide sequence ID" value="XM_002177270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQ05"/>
    <dbReference type="PaxDb" id="2850-Phatr32027"/>
    <dbReference type="GeneID" id="7196179"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32027"/>
    <dbReference type="HOGENOM" id="CLU_664747_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQ05"/>
    <dbReference type="OrthoDB" id="47368at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46640" checksum="F4910799D40421D5" modified="2009-02-10" version="1">MTSPSRRTSFDPDTLLPPSPDPAERPTVPSLSLAALRRSSPHDPSRTLRVTEQERASRTTSPALRLERLLTQRPRSNPRTRTPLRYESPLDPSALRRESLTPDPVESVHESRRLTIRPLAGSHVGTLPARVVEERRATPKSSKQGRSHRTVRRWNNDHFGSLAAEIKSSSHRAAEALLSSQQDAHLYRDVYDPNETKSKSMERFMTDVKLRNIREQFFEGEFASVTPVVPLRPHRSNPTTAADQMNRIDNRLHKVAVRACRNSGPAATVVDRFETFVIATFLGSAHTTRLLEESWWHDLLLQVPTVRRKPENTPASFMVLQFYFDPFSSTGGFHRLLLHAICQFHGLSAISNMVDVGDSKQARALIVSGRLTDAPHRMLQHLIREDTIKTIDHVSSEGLEPARPKLGVVTVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQH1</accession>
    <name>B7FQH1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177402.1">
        <property type="nucleotide sequence ID" value="XM_002177366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQH1"/>
    <dbReference type="PaxDb" id="2850-Phatr43056"/>
    <dbReference type="GeneID" id="7196249"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43056"/>
    <dbReference type="eggNOG" id="ENOG502SPGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389574_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQH1"/>
    <dbReference type="OrthoDB" id="46742at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC51865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="79782" checksum="DBE5880E15C0631D" modified="2009-02-10" version="1">MVEKSAGSSYLQAELESAERALQVVTRKIDNLNDIDPDSEQLLVKEGGEKSILKRLRMAETEAEEISFVRELSAWASSSPCEDGSNNFVLDGQKCFRLGQVLVRQGEPTKKLALYNIIYKEEYLPWYGYVQGKLTVSLRRSLSKAKYPSKEGCQKLLKERKQFQSEASLFTSIAGICECLQRIESAHQQVLYAVNGYSSSVSALDPVLMEICGPILERIRFHFLEASDDRPTSMRIDRLPEWLILYVRDNVLEGGPWELLHRGLAPFLASSWMVNFLNELVRIVQWVLGERGFFRHEHVAGPASKPSTLCDAIEHLIRFDADLQELVPQGLSTRLLSLIDIFVAGDEELLSWWLERERERVFTILTQQTTIRANKLVAPQAESFAALIRSVRIKAAVFSFSGPYLNRIATPLCMYFLDTVQEIASDLQSLLVQRTLPSDKDLETNILEWIELINGTHLVTSVLSLPIESHGDITLNGDEDLRRFGISVENLENALIGEFRKAFVESLLMERAKLASYLMRCPHFLALKGVEMVDASEVSVDLGETQRLLSVLLRVCDLVYTGRISNSTKDIEMFAPEVLRDSVLASVADKFLMVALDVDGMTPDLMRPGALTLSRDILDIFGTSALPSAALRLLDVVKFMCLEARHLGQVGDALCGLAEESPPLTIATFTADERLYEEALSMLRAKGFTWIELEDTLSILNRRRDLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQN7</accession>
    <name>B7FQN7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_32261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176901.1">
        <property type="nucleotide sequence ID" value="XM_002176865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQN7"/>
    <dbReference type="PaxDb" id="2850-Phatr32261"/>
    <dbReference type="GeneID" id="7196887"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32261"/>
    <dbReference type="eggNOG" id="ENOG502S2BE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_919754_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQN7"/>
    <dbReference type="OMA" id="LCYSSTQ"/>
    <dbReference type="OrthoDB" id="203682at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855197" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="298" mass="32868" checksum="9BAD99B2FFA196A0" modified="2009-02-10" version="1">MKILTLTPFPLLFLCKIAFDARLLTHAFSGGDPGGIGARGSKSALFQFYTESDPSDYDAADLTGEKSVAVDENEADSIIRDDLKRELLLLSSVTNRGEYASPDEQNIIVDIVAQLEALNPTADPASNCQGEWDLALSSTQFFRSSPFFQSIRVAMGENNKAMAENAFDIHDRATTASRVGRVRQTISDTKLLSEVELEVGLLPGFPIRVKGTVITSATLDVVSPETWETRIIETHVKGSNIPIINEFLDDARFEIPVSNIYNTLQGQVPVVPMKTFYLDEGVRITRDIDDNIFVFTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQR8</accession>
    <name>B7FQR8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_32292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177453.1">
        <property type="nucleotide sequence ID" value="XM_002177417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQR8"/>
    <dbReference type="FunCoup" id="B7FQR8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr32292"/>
    <dbReference type="GeneID" id="7196901"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32292"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_2_1"/>
    <dbReference type="InParanoid" id="B7FQR8"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="502" mass="54939" checksum="095D915272FAA9D0" modified="2009-02-10" version="1">MPSPVTQDGRTVPSVSAATFLATVASLPVWALTVLPLSLFYQAGKVIMKPVLPKAEQPRLDTGYHVSDSDILPRRERKYDMVVLGATGFTGRLAVRHLAKTYGVNKSVKWAIAGRSEAKLDKVKRELADELDIQEVESIDTIIVDTTRTSSMPALVKQARCVATTAGPFALFGSPVVEFCAKFGTHYVDITGESDWVKAMIMKWGETAQKSGARLVTFCGHDSVPWDLSVMKLQEALQKEFKDDLTSVTFWDEAVGGAPGGTIATLFSAVDGKSVKAPHADFDPFLRLMNGEKSEYVCRSDGPTWIHKSKSPWDDTGAWFGRWTTPFIMAQVNGAVVRWSHALREQGSKSLTYTEFAVTKDFKTAFVNHVGLIIVGSMMLNPLTSGLLKKYVFPKVGEGPSMKNMEDKHYLCIFGEGIGINGNRAESIMYFDKDAGCLETSRMLVESGLCLALEEDKVPAKHGGFWPPAAGLGNVLLKRLLETGTSFEARAISEASVRHSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FQY3</accession>
    <name>B7FQY3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_8754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176948.1">
        <property type="nucleotide sequence ID" value="XM_002176912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FQY3"/>
    <dbReference type="STRING" id="556484.B7FQY3"/>
    <dbReference type="PaxDb" id="2850-Phatr8754"/>
    <dbReference type="GeneID" id="7196934"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8754"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378788_0_0_1"/>
    <dbReference type="InParanoid" id="B7FQY3"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001921">
        <property type="entry name" value="AAA ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF117">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="165" mass="17506" checksum="C3AF6D7CD6570111" modified="2009-02-10" version="1" fragment="single">MSTEFQGEKALLSTISIPSGVLFYGPPGCGKTMAALCLGSSLSLPMINVRAANVLDKWLGGSEAAIRSLFSRARSAAPCILFFDEIDAIASNRGTDGESVDVMSRLLSTLLNELDGVNSEGQANVLVVACTNRIDDLDAALIRPGRLAEHICLQPPDENDAREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR26</accession>
    <name>B7FR26_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Limiting CO2-inducible protein B/C beta carbonyic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_32401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177505.1">
        <property type="nucleotide sequence ID" value="XM_002177469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR26"/>
    <dbReference type="SMR" id="B7FR26"/>
    <dbReference type="PaxDb" id="2850-Phatr32401"/>
    <dbReference type="GeneID" id="7196590"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32401"/>
    <dbReference type="eggNOG" id="ENOG502S48Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500105_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR26"/>
    <dbReference type="OrthoDB" id="38305at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040703">
        <property type="entry name" value="LCIB/C_CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016:SF1">
        <property type="entry name" value="LIMITING CO2-INDUCIBLE PROTEIN B_C BETA CARBONYIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18599">
        <property type="entry name" value="LCIB_C_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Limiting CO2-inducible protein B/C beta carbonyic anhydrase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Limiting CO2-inducible protein B/C beta carbonyic anhydrase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="545" mass="57481" checksum="9E5D3D8E0E725658" modified="2009-02-10" version="1">MFKKKQPVIAEPDTMNGDIFLSIAVAFLAIIAVNVVIKLVQYLKRTFASKPTTAKIRQVFPGAQTNDQLVETIRSSLEKFGFGENSLIATSLCCDEVNRPLDKALSETYGSYFSMGGLAGFPFGGLTSFGAMAAHIPDGGSCVVVYGPHVGVDSKGNVGTVERRGRQKGGSCCGSGVAAAGFVKSCLAGDAKPPGAPSDPLDAQQTFVNSMLLPHGARLNSAEEPMVELPYALFDAQDEFMRKIIEKGSGNVAGNGRIALLGGIQINTPADQPDYFLPLRFDVLSNKGETIEKIIDAPSRVTATKISSVFPNAVPNEKLLAKINSTLGCYGYGKNSLVATSLCCDEVNRPLEDDLKAAFGENFNMGGLAGFAFGGVTSFGAMAAHIPDSGSCLVVYGPHVGVDSNGKVGTVERRGRAKGGSCCGSGVAASMYVNAVRNGGEEAAPPTDPLDAQQSYVGNMLLPYGERLENAEDPMVELPYALFDAQDELMQKIVAKGCSNVAGNGKIALLGGIQINTPEGMADYFLPLRFDIRDNRGVVFDDFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FR27</accession>
    <name>B7FR27_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Limiting CO2-inducible protein B/C beta carbonyic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177506.1">
        <property type="nucleotide sequence ID" value="XM_002177470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FR27"/>
    <dbReference type="PaxDb" id="2850-Phatr43232"/>
    <dbReference type="GeneID" id="7196953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43232"/>
    <dbReference type="eggNOG" id="ENOG502S48Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500105_0_0_1"/>
    <dbReference type="InParanoid" id="B7FR27"/>
    <dbReference type="OrthoDB" id="38305at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040703">
        <property type="entry name" value="LCIB/C_CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016:SF1">
        <property type="entry name" value="LIMITING CO2-INDUCIBLE PROTEIN B_C BETA CARBONYIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38016">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18599">
        <property type="entry name" value="LCIB_C_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Limiting CO2-inducible protein B/C beta carbonyic anhydrase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Limiting CO2-inducible protein B/C beta carbonyic anhydrase" evidence="2">
        <location>
            <begin position="332"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="568" mass="60103" checksum="58DA3B67BB5C00FE" modified="2009-02-10" version="1">MQQRLQAVLFFWASKRDSLNLSKDLGADMEEAMETGDIFLGTVVAVLTIVGISVTINLLKFLWRSFAAQPTTAKIRQVFPGAQTNDQLVETIRSSLEKFGFGENSLIATSLCCDEVNRPLDKALSETYGSYFSMGGLAGFPFGGLTSFGAMAAHIPDGGSCVVVYGPHVGVDSKGNVGTVERRGRQKGGSCCGSGVAAAGFVKSCLAGDAKPPGAPSDPLDAQQTFVNSMLLPHGARLNSAEEPMVELPYALFDAQDEFMRKIIEKGSGNVAGNGRIALLGGIQINTPADQPDYFLPLRFDVLSNKGETIEKIIDSPSRVTATKISSVFPNAVPNEKLLAKINSTLGCYGYGKNSLVATSLCCDEVNRPLEDDLKAAFGENFNMGGLAGFAFGGVTSFGAMAAHIPDSGSCLVVYGPHVGVDSNGKVGTVERRGRAKGGSCCGSGVAASMYVRSVRNGGEEAAPPTDPLDAQQSYVGTMLLPYGERLENAEDPMVELPYALFDAQDELMQKIVAKGCSNVAGNGKIALLGGIQINTPKGMADYFLPLRFDIRDNRDVTIEDFLVETGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRS6</accession>
    <name>B7FRS6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_43297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177854.1">
        <property type="nucleotide sequence ID" value="XM_002177818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRS6"/>
    <dbReference type="PaxDb" id="2850-Phatr43297"/>
    <dbReference type="GeneID" id="7197071"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43297"/>
    <dbReference type="HOGENOM" id="CLU_907513_0_0_1"/>
    <dbReference type="InParanoid" id="B7FRS6"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC50668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="307" mass="32763" checksum="3D22FB1EE228F1BC" modified="2009-02-10" version="1">MSSNSNSSASELAVYANLVSYKYDGDSKTHSANRGGDANDMSVYGNAVKVSLHGLPVAGLTDDDDDSSVVNDGRLLVKDPQVVAAQEEDVKDEQSISVDESQLLSTRKAFAPCTDPNSIIKVSLDHRHGFLGRRGNVRVLDSAGKPFAGGVHLKEFQRHLLRPSYLLRTANKTPVALCVQQNAQTGSSTKVFNIYSTRQGVTADVTKVVHVAGVSYYPAYRVELASAASDCVVSTWTGKESVPIWELRTDANTVTIQEINVGRILGSIEQHEGLKTGCDIVLNAGVDPALVLCVGTILEASCTAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B7FRZ3</accession>
    <name>B7FRZ3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_9728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177579.1">
        <property type="nucleotide sequence ID" value="XM_002177543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FRZ3"/>
    <dbReference type="PaxDb" id="2850-Phatr9728"/>
    <dbReference type="GeneID" id="7197399"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9728"/>
    <dbReference type="eggNOG" id="KOG4192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_3_1"/>
    <dbReference type="InParanoid" id="B7FRZ3"/>
    <dbReference type="OMA" id="INIACLD"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="14810" checksum="2725B259107A2594" modified="2009-02-10" version="1" fragment="single">MEVFFARCHCGRVQGRFICNATHLTAIDCNCSDCYMRKNVHIVVPISAFQISMEESLEDATILYEWGTKAAARRFCKVCGIMPWYKPRSNPDGVAITIYCVDWTKNGTSQPPKIDVMNFDGANWEQSMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7FS90</accession>
    <name>B7FS90_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177624.1">
        <property type="nucleotide sequence ID" value="XM_002177588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FS90"/>
    <dbReference type="PaxDb" id="2850-Phatr43441"/>
    <dbReference type="GeneID" id="7197444"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43441"/>
    <dbReference type="eggNOG" id="ENOG502SQPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563200_0_0_1"/>
    <dbReference type="InParanoid" id="B7FS90"/>
    <dbReference type="OMA" id="LERTHRY"/>
    <dbReference type="OrthoDB" id="39916at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="48085" checksum="6B9788133C270FCF" modified="2009-02-10" version="1">MSNKSNLDKAERQNGSKASATTIQAFHMRSEAEVGLEQPAMRAVALLGGPTLTVPGPFLGVSKPNATGLLRPPIGRTADPATGRASFEVKQEWSGLTASSAWDVKGEVLDMLPEDFPLERTHRYISGVQASVVAARISESLRSHSIEAEFDCQKAKAKCKTQDYVSFRIRLYAGGENADPVIVEVQRRCGPVSSFMVSCRAILDAAEGKVGHHASTPNKKIPAVAKSVRQMKCLQSVLAKQEVLVDDCIADLGRIASLLKSDRFDQNVLAMENLCCLTDPIRSSGAAALRVSKCVILGDEQSEIREEVRALTERDVFDRDEVSRHHSHQLRQLAHVTFANTLSMCSKSGHLATAIKDQKWFHEFLIPTLLDELKLAKVSPCSASAASRSLFSVMTSSESALRQILEQDVMETLKMANEFGRARHALLFNETARLLKLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSM1</accession>
    <name>B7FSM1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_32784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177689.1">
        <property type="nucleotide sequence ID" value="XM_002177653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSM1"/>
    <dbReference type="STRING" id="556484.B7FSM1"/>
    <dbReference type="PaxDb" id="2850-Phatr32784"/>
    <dbReference type="GeneID" id="7197294"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_32784"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499209_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSM1"/>
    <dbReference type="OrthoDB" id="41909at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002854961" description="Ankyrin repeat protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61015" checksum="1BB02735F81E6981" modified="2009-02-10" version="1">MQLHRPSNRFWGAVALSLLVLGPRESFSFLGAKQFATQLRQISSHRQREGDYTIQRTSTIRQHLHHKPSMTPTQEDEAPSVPENRPWEQRAAKPRTARRLNHAFKYLYRHVDPKRTNQTLSSEDPLSYLVHEGGYTRDQVIIMNQTFPPLLSLSVSRQLRPKMRFLKETLGLLHPTSINLPPQYFGARLERTLAPRHAFLAFHKLPHGPQLWQEDPAAAAVVHNQTTTVQPSRLSSFLVAGRKTKRFAALCQKWQQEKIMDCNEVQHPPITDKQIEAFDVLFGRGLMAAARNDLVQWNNTWPLDYINVTSAELTQLLIDHGAPPLERDHRGATLLHWAAGVGNLPGVQTLLPHFPQGVRVTTKRDHATPLHWAAAGVNAREFGTGGSVKVCQWLLTQIETSDEVKRYVNQQTRDGNSPLMWASWSGTLDTVKLLVRHRAQAVGVANRNGCTVAHWAASGGNVEVCRYLARVAGVDFSQANSGGNTPLTHAVAFGRTKVVEWLRSEGVECHNDNAAYTLAQDFVQWTDGDHRRKQILQLFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSW1</accession>
    <name>B7FSW1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_43618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177734.1">
        <property type="nucleotide sequence ID" value="XM_002177698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSW1"/>
    <dbReference type="PaxDb" id="2850-Phatr43618"/>
    <dbReference type="GeneID" id="7197339"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43618"/>
    <dbReference type="HOGENOM" id="CLU_840621_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSW1"/>
    <dbReference type="OrthoDB" id="56233at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC50548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35366" checksum="421418EFF54F13B6" modified="2009-02-10" version="1">MVSPLSARLLAGYSSSISSDGISRTSSHRTGSNQPPSSLLGGRSGYSADSDRMSSKGPPCTIGMTSKRVKREPDSRDASPGKRRKLEEMNFDAACAKDNLERAGISLPSIMPNDSKIFPLSSKVDMSKVEHVSSKDFQPLSWAPPAGAVDLFASVLQMAQACKSCYNTIPVVAGSKQAVTDPDTSTSSVTDTDSEEGNTSSADSQRDKPEPSLVAMGDALSIDMQALGLKGERTVNRVSARMVVLAFEPFTVIHVNRAYTKMTGVAPSDILGKPFRHALDKGELSDLLLSTGECKSLMDINGRVLRTKATKQLQCQMNVSKLSTEYYSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSX2</accession>
    <name>B7FSX2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RimM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_43626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177741.1">
        <property type="nucleotide sequence ID" value="XM_002177705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSX2"/>
    <dbReference type="STRING" id="556484.B7FSX2"/>
    <dbReference type="PaxDb" id="2850-Phatr43626"/>
    <dbReference type="GeneID" id="7197495"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43626"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_814999_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSX2"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.240">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33692">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33692:SF1">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852643" description="RimM N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RimM N-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="341" mass="38073" checksum="02897EABC34FA477" modified="2009-02-10" version="1">MVLRQRRIATLFLLLSEARSVHSLQGVTTPIRKRNFCAYALGEADELARSVGQRREKKNKYIEFSKVTSGKDPFESLLEESFSKRKALDDDIARKDELSSSPPKIGNSGNLSFPDNKNIDPYDPTTFGYIEVGIVRGAHGVHGWVKVKPTTSFPIDRLCVAGIKHLKPPKKRAPRKVLLLEGKRRNAEEYLIKLEQINDRDEALKLRGSLLYVREEEKMATDQEEYMVSDLVGSEVFLDTLDTVENPLFLGVVNGVVFADEMCSIPGLGHDMLEVVLRKGQDGMASLRDELVLIPMVPQIVTHVSAAKGVIHINPPSGLLDLTYLREERAKLKGFLPPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B7FSY0</accession>
    <name>B7FSY0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_25420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178061.1">
        <property type="nucleotide sequence ID" value="XM_002178025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FSY0"/>
    <dbReference type="FunCoup" id="B7FSY0">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FSY0"/>
    <dbReference type="PaxDb" id="2850-Phatr25420"/>
    <dbReference type="GeneID" id="7197349"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_25420"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_0_0_1"/>
    <dbReference type="InParanoid" id="B7FSY0"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC50875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26106" checksum="716CA7FEB95C51DF" modified="2009-02-10" version="1">MTDVIDGTGDVSPALALAAPTIQGGLTPEAARLFRVYRTIANMLDKRGYMVPKTLREITPSAFKERFGEYPSRENLTILVEKADDDTNQLFIFFPEDEKVGVKPIKVYTDRMRAESVSNAIIILRVDITPFAKQAVQEMSDSFRIEHFKESELLVDITKHQLVPVHQVLTPNEKNELLKRYRLKDSQLPRIQSNDPVARYYGMRRGQVVKIIRPSETAGRYVTYRICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7FT22</accession>
    <name>B7FT22_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_5104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178083.1">
        <property type="nucleotide sequence ID" value="XM_002178047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FT22"/>
    <dbReference type="STRING" id="556484.B7FT22"/>
    <dbReference type="PaxDb" id="2850-Phatr5104"/>
    <dbReference type="GeneID" id="7197517"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_5104"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_1_1_1"/>
    <dbReference type="InParanoid" id="B7FT22"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC50897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28628" checksum="F773352A9A3156CA" modified="2009-02-10" version="1" fragment="single">NKNVYIWAGFFTISLVVYSMLSGGDFSFLMTYGAMSRMFGFGILNVKTFKSERASGVSVKTLQLYCLVFFFRLTSIIRHEGYLPYDKSGDWLYHFIEIAALLFTASALYGCMVPFKGTYQKELDRFGEFNVPEGLGAIYLAGPILIIAILIHPNLNADFISDTAWTYAMYLESTALMPQLYMFQKQASGVVELLTAHFVAALGFGRLMEFFFWIYSYHELANSSGSKLPGYLALFSQFVQLVLMIDFFWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTD8</accession>
    <name>B7FTD8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_43764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178137.1">
        <property type="nucleotide sequence ID" value="XM_002178101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTD8"/>
    <dbReference type="STRING" id="556484.B7FTD8"/>
    <dbReference type="PaxDb" id="2850-Phatr43764"/>
    <dbReference type="GeneID" id="7197041"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_43764"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="InParanoid" id="B7FTD8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC50951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="365" mass="40784" checksum="AED12BF3B7AA7F6A" modified="2009-02-10" version="1">MSIRSKQTTEFHFERVLLYGKRKKSLPPKSCLVFKVTDMTCFNSVSQPTSCWIVQVFLVPICVADVSDAMSRTCRTAILVTGSTDGIGLTTAKNVASRGYDVIIHGRETTRLDQARKAVHAYAVQHSSDPGRLFPLPPADFSSIRECHGFAHDVRNLCKEKDLQLCVLMNNAGVYSEKHIITEDGLEQTFAVNVVAPFIVTSLLLPTLLQQKSRIVIASSISQCGKIRSWKDLHYQNRSYSADASYSESKLLDAMLSMEMADRLQKAGFGTNQITCNCLDPGTVNTKMLLAGWGACGIHVEDALDQTWLCTSEEVENETGKYFVYQKDRSAQSSAYDQNERNKMWALLSELAPEAAAMWTFDWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTE3</accession>
    <name>B7FTE3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heme oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHATRDRAFT_55416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178140.1">
        <property type="nucleotide sequence ID" value="XM_002178104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTE3"/>
    <dbReference type="STRING" id="556484.B7FTE3"/>
    <dbReference type="PaxDb" id="2850-Phatr5851"/>
    <dbReference type="GeneID" id="7197280"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_55416"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063325_1_0_1"/>
    <dbReference type="InParanoid" id="B7FTE3"/>
    <dbReference type="OMA" id="PPEFICH"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016951">
        <property type="entry name" value="Haem_Oase_decyc_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35703">
        <property type="entry name" value="HEME OXYGENASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35703:SF2">
        <property type="entry name" value="HEME OXYGENASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC50954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29681" checksum="92DB6EA11A27C1C5" modified="2009-02-10" version="1">MRQHIVFGWLALTGAEIGAFAPAFSVSRQTSRRQQVFQPRLHAASADSTATTGSFIDTELRGAAMKLHTRQQAPKEGEAEAKPREPYTPTRDDYLAFLVDSKHVYEAMEEIVNSREELAPFRNTGLERTGPLEADILFMVEEYGLKRPIVGEPSESYARKLRSIETTPEFMCHFYNFYFAHTAGGRMIGKQMSALLLEKRTLEFYKWDGDLNEIKSRVKKSIEEMAANWSQEERQECIDATRDAFQGGGGINSNLAGGQHPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FTF5</accession>
    <name>B7FTF5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_9912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM000606">
        <property type="protein sequence ID" value="EEC50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177834.1">
        <property type="nucleotide sequence ID" value="XM_002177798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FTF5"/>
    <dbReference type="STRING" id="556484.B7FTF5"/>
    <dbReference type="PaxDb" id="2850-Phatr9912"/>
    <dbReference type="GeneID" id="7197285"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9912"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_3_1"/>
    <dbReference type="InParanoid" id="B7FTF5"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="186" mass="21501" checksum="27EF8600DF3466F0" modified="2009-02-10" version="1" fragment="single">LGAGCYWGTEKYVRKDFRKKFPNSIKTATVGFMSPLDGVRIQNPTYPQVCSGQSGHIEVLFVELNEPDKHFEELIRFFFQFHDPTTKDRQGNDRGFQYASWIFCDDEPQALIAERVRGELQTLLDANALNVYDRKTVSTKISPMKEFTPAQAEHQEYLAKHPNGYCNHRIRFKHWPVISKKEGASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FU30</accession>
    <name>B7FU30_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ethanolaminephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_33864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178244.1">
        <property type="nucleotide sequence ID" value="XM_002178208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FU30"/>
    <dbReference type="FunCoup" id="B7FU30">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FU30"/>
    <dbReference type="PaxDb" id="2850-Phatr33864"/>
    <dbReference type="GeneID" id="7197884"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_33864"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="InParanoid" id="B7FU30"/>
    <dbReference type="OMA" id="SHCEKYN"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52092" checksum="AF9D21A58603D2C1" modified="2009-02-10" version="1">MRVFRLALDRCHIVFYPLRGVDGARWDRNIVSAGSHLLLLSCGSAVVSNNSLLSFATDMVTVSADDLLHEVTTGGSSSDVKHKQPIDGRDQHVWLFEPPASQGVLTQDGLTQIVFHKYHAGTYTMLDNFLNPYWTYLTECLPMNMAPNLVTALGGMHCVVAYFITWIYLPSFDTLAPNWLLLLNGYCTIAYYTFDCMDGKQARRTGSSSPLGQLFDHGMDCFCLLAHLSTAHTWAMGGNTPWFWASQAALQFSFFVAQWEEYYTGILPHANGQFGVTEVNYGQALLSVINAFVDRKVVYTAASLAAIGTAWPAMMTYLIFASIFRVCSVIGNTKGRFSALSKLTSPLIVSIVPFYIPSVAREREVRFIHLTIGLALCLVTIKIIVFSMAKQSYAVIQGDILPCLLAAAWVRHDVRLTEAGSHLLWQVLSVWYFCRMLYWTNSFIQQVCERLDINLFTIKLTKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUE9</accession>
    <name>B7FUE9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_54251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC49975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178310.1">
        <property type="nucleotide sequence ID" value="XM_002178274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUE9"/>
    <dbReference type="PaxDb" id="2850-Phatr54251"/>
    <dbReference type="GeneID" id="7198064"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54251"/>
    <dbReference type="HOGENOM" id="CLU_525305_0_0_1"/>
    <dbReference type="InParanoid" id="B7FUE9"/>
    <dbReference type="OrthoDB" id="39947at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855019" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC49975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="519" mass="60220" checksum="7C6F61DF2EDF9AD8" modified="2009-02-10" version="1">MRSFLLWSLVASFATAQEGSNLDRFNYRGTEGTDYGPEDWDQVSCSDTENCLGWPDAFEASRGWSLKDNFCRWCPAGSSSCGTHHQSPIDLQRNRAVPGDPDENECIDVHWMAYYDSTCTWDTLKELNAFSVERHALKVVQPITETTSGEWEIACRDDSGKRFGRIDFSKGFSQWWFLSHMDFHVPSEHTQEGKRYDGELHMYHFYSVTGAEAGIDNEMASVAFFLEAYDDIPDYPMLNRLICQWREAEEKTREECGLPSILTEYPGCFFYNRGHTDSAVTTQSISNGQRKLRTTSRNLRPKVKSVHDIILQNHEQMQSNATFKPHKLILSEDDHAEADPDFDWGAFVAEQVAKSTSSQEHRELMNYDHVGPWFNYFPLVDVRTEYYYRYSGSQTVPPCYGRHIGGSRKQTNHWRFMKDPLRVTQRQIDEMHRLLKERIAPLDDPLASCQPDTAAKVNEDDPTKISVARPLMETRDTHYKVFCECIDWPSKWPEDRAWCEQGFMDRLYTHPYNFQTDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7FUT6</accession>
    <name>B7FUT6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 11">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HemE_2</name>
        <name evidence="17" type="ORF">PHATRDRAFT_19188</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 11"/>
    <dbReference type="EMBL" id="CM000607">
        <property type="protein sequence ID" value="EEC50318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178653.1">
        <property type="nucleotide sequence ID" value="XM_002178617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FUT6"/>
    <dbReference type="FunCoup" id="B7FUT6">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FUT6"/>
    <dbReference type="PaxDb" id="2850-Phatr19188"/>
    <dbReference type="GeneID" id="7197643"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_19188"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_2_1"/>
    <dbReference type="InParanoid" id="B7FUT6"/>
    <dbReference type="OMA" id="CAGQRGH"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000006">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855470" description="Uroporphyrinogen decarboxylase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEC50318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="409" mass="45352" checksum="CFB6BC2C265DB7C7" modified="2009-02-10" version="1">MKVSHVAFSLFLAGSQTTAFTNPVSNSAKQQSFRLPSSASSAADTTSSANVAQKSTQDPLLIRAARGEKTERTPVWMMRQAGRHIAEYRDLCKKYPTFRERSEIPEVAVEVSLQPWRNYQTDGCILFSDILTPLPGIGCEFTIDEKVGPLMEPMRSYDDIKKMHPMDPYKSTPFVAEALKALRQEVGPETAVLGFVGCPYTLATYIVEGKTSKEYLEIKKMALNEPDLLHAILQQLADNIGDYALFQIENGAQLIQIFDSWAGHLSPRDYNTFAAPYQKQILDKIKEKYPDVPTVIYIKHSGALIERMAATGVDVVSLDWTVDMADGRDRIEAGRKSAGLEGRGGVQGNLDPAVLFANHDVIEERAIEILKKAGSVGHVMNLGHGIEAATPEENAHHFIETVRGYRHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVA8</accession>
    <name>B7FVA8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase (NADP(+))</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_45017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178894.1">
        <property type="nucleotide sequence ID" value="XM_002178858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVA8"/>
    <dbReference type="STRING" id="556484.B7FVA8"/>
    <dbReference type="PaxDb" id="2850-Phatr45017"/>
    <dbReference type="GeneID" id="7199682"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45017"/>
    <dbReference type="eggNOG" id="ENOG502QSXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025308_1_0_1"/>
    <dbReference type="InParanoid" id="B7FVA8"/>
    <dbReference type="OrthoDB" id="408849at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE (NADP(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC49592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="89325" checksum="1AF5957005887B2E" modified="2009-02-10" version="1">MFRSSTVLLATRSSALARHSATAVAPTRRRCAFVLGHSDPPTRLAGQPRFLSSIDSPLPPTSNHRHQPLEHARGSILYTETDEAPALATFSLYPVISKFSALANVDIVPCDISVAGRVLAAFPECLKPSQRVPDNLSYLGKKALEADCAIVKLPNISAPLNQLLECVNELRHKGYDVPLYPHEPSNVEETDVKHRYDKLMGSAVNPVLREGNSDRRVAAPVKAYAQKNPHRMGLWSKASRTHVAHMETGDFYETEQSAVMALPTSVSIVLATKNEGEIVLKAETPLEEGEVVDASRMSVKSLRDFYEREMQDAKDSELMLSLHLKATMMKVSDPIMFGHAIRVFFQDAFDKHGEVLASIGANPNGGLGSVYETIKSKLPADQAATIQADFEACFEDRPWLAMVDSDKGITNLHAPNDIIIDASMPVVVRDSGKMWNKLGELEDVKCLIPDRCYATMYQEVLSYVKTKGQFDVATMGSVANVGLMAKKAEEYGSHDKTFEIPSDGRVVVKDNNTGEVYFEHVVNAGDVWRMCQTKDVAIRDWVRLAVERARATGDRTIFWLDKRRAHDASLIKKVNTYLKDHDTDGLDISIMRPVDAVRISMERATDGKNTISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLLAGGGLYETGAGGSAPKHVQQFVKEGHLRWDSLGEYLALAVALEGLADTAGNPKAKILGDCLNKAVGRILTNRKSPSRVVNQIDNRATNFYVSLYWADFLQQEDPSYKAIFESLTENRGKIVEEFSQCQGTAVDLGGYYLFDPAKTKAAMNPSPTLNKILSSFGPDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVI4</accession>
    <name>B7FVI4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_8511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178710.1">
        <property type="nucleotide sequence ID" value="XM_002178674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVI4"/>
    <dbReference type="GeneID" id="7199726"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8511"/>
    <dbReference type="InParanoid" id="B7FVI4"/>
    <dbReference type="OrthoDB" id="2150639at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="68" mass="6553" checksum="F6CA7F94068A41A8" modified="2009-02-10" version="1" fragment="single">SSVPTVAPSGTPSSIISNQPSSAPSMLPASVPTMLPSGTPNGAPVVAPSQNPGILPSLPPSQNPSKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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    <name>B7FVI6_PHATC</name>
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        <recommendedName>
            <fullName evidence="6">ABC-2 type transporter transmembrane domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEC49410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002178676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVI6"/>
    <dbReference type="PaxDb" id="2850-Phatr44753"/>
    <dbReference type="GeneID" id="7199875"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_44753"/>
    <dbReference type="InParanoid" id="B7FVI6"/>
    <dbReference type="OrthoDB" id="54066at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="372" mass="41723" checksum="D3B1860CE4CDBDF6" modified="2009-02-10" version="1">MIGSNGDVEIGTLAGETWIGNLSLPRESFSSHRSFKIVNIFMLFVFALVYDFIGFFYIERTREWTHNEICRPHAKRCGQDYFIAVLFRETVSGLYSRFSYGLGLLITDIPYHILNTFLIWVFFYFLVDFRMDGESMGYFLIVLFLANRVIRAMPDGWVWANLFHHVLQGLVTNEISGKLYSFDLGLDLKPPLLNATNVVVFDRGIDPSDSIPRQVSSLLTLTILAGGGINPSSSIGLLPWVQCNIVNEFSSLDVESIGQRFPSNVGMDTRQNPFGVTATGVPDGFNEDQLIRLLNADQLEPTICLLQAVLPTVERLFGVVAFVLDIFQSGLAIPGDLILFFFGWAGSKAEEGIVAPWKWHYCLTAVAVFWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7FVU8</accession>
    <name>B7FVU8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
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        <lineage>
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            <taxon>Phaeodactylaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002178767.1">
        <property type="nucleotide sequence ID" value="XM_002178731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FVU8"/>
    <dbReference type="PaxDb" id="2850-Phatr34371"/>
    <dbReference type="GeneID" id="7199558"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34371"/>
    <dbReference type="eggNOG" id="ENOG502SNFI">
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    <dbReference type="HOGENOM" id="CLU_892719_0_0_1"/>
    <dbReference type="InParanoid" id="B7FVU8"/>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC49465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="308" mass="34087" checksum="61745582D63018FE" modified="2009-02-10" version="1">MSSLAMELLVQFSSGDFAFSGELQAFWMAVQGAMMVRLGPNKDRSLNWFHAFSLSVIGGFGGGWLGFIWMGRPSSMLSNDLNMASCIVAFILVNYTPMDIGFKCCNNIMGKIATVVFAQLFRSLGVAKFVMVCFETFKDSPSAYYPIPVFGPILYATLLGNMGGFVLKGFNGHFANGMPWPVQNGLFCATFYHFYVNDQTGPIGIFLRKSLRMAHFLGFKDNQTFALVVVTMFMQVMGILQMPTFLGPSFTPFGSAILSPFRDSSTWKTGEKDTAYSTAQAEKKKRRRGKGTVKTTSARIHNSKDKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7FW62</accession>
    <name>B7FW62_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELO5b</name>
        <name evidence="11" type="ORF">PHATRDRAFT_34485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000608">
        <property type="protein sequence ID" value="EEC49746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179048.1">
        <property type="nucleotide sequence ID" value="XM_002179012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FW62"/>
    <dbReference type="SMR" id="B7FW62"/>
    <dbReference type="STRING" id="556484.B7FW62"/>
    <dbReference type="PaxDb" id="2850-Phatr34485"/>
    <dbReference type="GeneID" id="7199773"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_34485"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_974747_0_0_1"/>
    <dbReference type="InParanoid" id="B7FW62"/>
    <dbReference type="OMA" id="RTGWYMW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEC49746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="286" mass="32613" checksum="41C67744814209C9" modified="2009-02-10" version="1">MKVSLLEKLWTVWNPSILDSIDGRPISSSIRGLFTDFEYDRLPTNPYVAALLRPEVVLGLIVLYLVSKSPLQWAMKVTRFDSTSGAFHTFIALHNLGLAVFSWICAWNSWTAVLLHVHQFGLWSTYCDPDGRLWQNGLGVWSTIFYISKYYEFLDTWVLVLKGKDASFLQVYHHAGIVFCMWGAVASQSAWLLFVVLLNSVIHTLMYLYFFIKTISPTTEIKIAKYLTMAQITQFMVGITCTLGVLYMGDSCDSQSSRFALVCLHVYGWGLIALFMAFAKRKYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWC5</accession>
    <name>B7FWC5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_45064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179137.1">
        <property type="nucleotide sequence ID" value="XM_002179101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWC5"/>
    <dbReference type="STRING" id="556484.B7FWC5"/>
    <dbReference type="PaxDb" id="2850-Phatr45064"/>
    <dbReference type="GeneID" id="7200076"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45064"/>
    <dbReference type="eggNOG" id="ENOG502QQRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_1"/>
    <dbReference type="InParanoid" id="B7FWC5"/>
    <dbReference type="OrthoDB" id="10249837at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06460">
        <property type="entry name" value="M32_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217:SF1">
        <property type="entry name" value="CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="METAL-DEPENDENT CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52034">
        <property type="entry name" value="PEPTIDASE_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852743" description="Carboxypeptidase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63638" checksum="377F50774CA7B659" modified="2009-02-10" version="1">MRLLVLSTSVWLMLALATSAFSFARHPSATAAASSLTSRSLRLLMSAAASTPTTPGTDVASTTGTTTASTADTYDQLVSRLQTIARLGQSQAVLSYDQMVFMPSSAASASARGAQLSALATVVHEKATDPAMNGILQTLESVEHQSALTDEQRKLVALARREYDQKTCIPPALEQKKAELSSSAYAAWTKARADNDFAAFAPVLKECFDVASQVAQATLTGVAGAGRSVKADDPNAKYTQMLDEFERGMGPERIDAIFDEIETQLVPLLQRVLNASHQPSTDCLHGNFAIASQEALSKAIVTTAMGFNVEKGRIDVSVHPFTTSFSPADVRITSRFSDTEWYQGLAGSMHEAGHALYEQNLPDTSLPIDTALSMGCHESQSLFWERHVGLSKAFWKYATPLLKEHLRVDVTPEEVYAAVNVVAPTLIRVEADELTYPLHVILRYRIERQVVQGTLAVEDIPSAWNAAMKELLDVDVPSDTMGCLQDVHWSAGAIGYFPTYLIGSATAAQLAHYCRRDLANFDELVETGQLEPIRTWLTNKIHQHGKRYASLDELLEDQLGESLNPKYFVDYLVGKYSELYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7FWM0</accession>
    <name>B7FWM0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleoprotein associated TUDOR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RAT1</name>
        <name evidence="5" type="ORF">PHATRDRAFT_45147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179405.1">
        <property type="nucleotide sequence ID" value="XM_002179369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FWM0"/>
    <dbReference type="STRING" id="556484.B7FWM0"/>
    <dbReference type="PaxDb" id="2850-Phatr45147"/>
    <dbReference type="GeneID" id="7200331"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45147"/>
    <dbReference type="eggNOG" id="ENOG502SEP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281255_0_0_1"/>
    <dbReference type="InParanoid" id="B7FWM0"/>
    <dbReference type="OMA" id="DSEWIDF"/>
    <dbReference type="OrthoDB" id="128459at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="811"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124187" checksum="7144C7FCD4001AA0" modified="2009-02-10" version="1">MPFGASSSSSWWNGTVRDDASHPSTTVPYRLSSLHVDEDIQNAAAGLLGIAHTHVRRGEATTLWSQSSMWGWKPDATMNTTMTNTSTTTATTTTTTTTNDAPSPSTPWVPSGECLRPHTAAAIQPSGPLAPPPLFASPDRRSSLGTTNAHAASNRVQPQRTPAAQQATTTAHGTLSNGSCSSTSPPPLVIDGFQVDGTASCPVGRRPRPHQVQRVSPVPVPHRSTSQASSHSNKPHTVPLLPPPSQQLLLPPPQQQHLPNFIDGSIRVGRTESNTRQPESDAPVPSNFLTPPPQCVGATHSGRVVQKPLTFAEEIFGKNGRPPVLLHRNHPKRVLTKPQLRKLIATHQQKTTKASARISANVVVPPRITVGNSVAPPPLLRINSNVTGRVVKKPVNFADEIFGKNGRPPVLDDATLARLARARTTTVGLVRPSGESIHNNTSNRRTKDSRRRRRDIRTVTRATPKAEIDPVVTEENLNSPRKRHRSRKNATDETDTTNGSPRSRRRSRADREPVSVDRVPFYPDTVTSRRRASRKPKLFAQERFGKNGRPPSPVLIAEAEPSGTVLVSPRRYTMTPPTEEKSPRTVSDSSIEADEGKVQRSSFGSEREHSDDLESNVNVDLGESTVVGNATQGTKDIESVVVPDGTMRDRNTHGTKIARWLQRKRNEWERQKSQSRVLGLPSNKMGSAYDSAPPDTTNEKRLLSKHKSDRAGKESVRHIKNLEPERCDSRSIVSKQANKSLDKSIFDEDSVDNTVAASDLVDSESENGPSIAKSTDSPISGGSRLRRGLFKKENEDAQPSHKRRGRKRPVDLVVVGARVEVFWKEEQQYFAGIVMKQREHKRAFYVEYDDGDREWIDFAAHKFRLIESVTHDTSKAKRKAEILNALCKKRVSEIELTSSETKKYAATGGFHEINPIGTRVKKLRRGRKKGVSILDDSNNGEENDPEDNIYGITVGCRVAVFWEGDRKYFNGSVTRKRSANRKNFFVEYDDGDSEWIDFDDHQFRLFITDERDEVHTDTAEDYDEGEALDDLNEEHEKGDASKVSIGCRVAVYWDGDNEYYKGKIMSIKKDKKASFYLKYDDGEDEWINLRRHKFVHLPKKKSGGRPQKKRKTDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FX21</accession>
    <name>B7FX21_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AP1mu</name>
        <name evidence="7" type="ORF">PHATRDRAFT_54375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000609">
        <property type="protein sequence ID" value="EEC49083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179260.1">
        <property type="nucleotide sequence ID" value="XM_002179224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FX21"/>
    <dbReference type="FunCoup" id="B7FX21">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7FX21"/>
    <dbReference type="PaxDb" id="2850-Phatr54375"/>
    <dbReference type="GeneID" id="7200276"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54375"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="InParanoid" id="B7FX21"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="171"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC49083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="439" mass="49836" checksum="F5B26345B3AAD31E" modified="2009-02-10" version="1">MVASAVFITDLQGKNIISRNYRGDVPMQKALERFQTYLLETTDESKKPVFHVDSNGDSYIYIALSNLYLCAVTTRNSNVALILTFLYRLSQVFKDYFGTLEEESIRDNFVIIYELLDETMDHGLPQALDSMILRSFITQGANRMSEDARNKPPVALTNAVSWRAEGIKHKKNEIFLDVVEKLNLLVSANGTVLHSEILGAVKMRSFLSGMPELKLGLNDKLMFEATGRANQAKGKAVELEDIKFHQCVRLARFENDRTISFIPPDGEFDLMTYRLNTHVKPLIWVEAVVEPHKGSRIEYMIKTRSQFKSRSVANNVEIIIPVPPDVDSPSFKCSVGSVSYLPDKDSAVWTIKQFHGGREYLMRAHFGLPSISASDIDPEAKKKGDNAWKAPIRVQFEIPYFTVSGIQVRYLKIIERSGYQALPWVRYITANGDYQLRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYA0</accession>
    <name>B7FYA0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_45614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179901.1">
        <property type="nucleotide sequence ID" value="XM_002179865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYA0"/>
    <dbReference type="PaxDb" id="2850-Phatr45614"/>
    <dbReference type="GeneID" id="7200655"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45614"/>
    <dbReference type="HOGENOM" id="CLU_060859_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYA0"/>
    <dbReference type="OrthoDB" id="6052527at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC48887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43827" checksum="27E824CDFA54FE9B" modified="2009-02-10" version="1">MLRLRTTFMFTIAGSVMALLVNRVQVALILFDESDPLYTRDPSFTPTEPDPEGRQDTFSFKNLSNFIALEPTPRPRVESLVNGPNITGDVAWLMHLAVVGFAKCGTTAMQAYFDRHPQISMLDGEHCSIRDEGYAASNLVKKLAEELPRGNYIRGAKCPSYLEIPQALHTLSTLFPNARFVVGVRHPVLWFQLLPALELIGDCEKVGPRYKTGGVCTHQAKFHEPLALLGKTKMSTPEEQQYFPKGFSSFVNQTGSSGHEIFLYDISQIADNNERRQRQFRDDLQRFLHVDEPFSPLSEDKESRRRLSGLETSTFPNAHKRINICDRKYDGLRDVLLKIGKDASRWIRQYFIHAGGVHVSSVEFLDQALARWEIDPCELRLKKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYG1</accession>
    <name>B7FYG1_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-activating enzyme E1, protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBA1</name>
        <name evidence="6" type="ORF">PHATRDRAFT_54460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179732.1">
        <property type="nucleotide sequence ID" value="XM_002179696.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYG1"/>
    <dbReference type="STRING" id="556484.B7FYG1"/>
    <dbReference type="TCDB" id="3.A.25.1.1">
        <property type="family name" value="the symbiont-specific erad-like machinery (selma) family"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr5043"/>
    <dbReference type="GeneID" id="7200448"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_54460"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYG1"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852814" evidence="4">
        <location>
            <begin position="24"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC48718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123352" checksum="6C0F8592122D613A" modified="2009-02-10" version="1" fragment="single">MNYCWRFCLGLLLEQALLRDSFGVRFVPIFHPSPRRVKVHIRNALSSRGGGGGDAVGETEDDEERYSRQVFALGAEAHKRIRSSTVYLDGPGLDAAYFKGELDDLGRAYHRAARSETGKSDDDCDVSDEEVLMEYLKRLNPSVQVSVVKYSDFRPLDDSLRGVLLCVDRCHEKLLVMNGLARRHNLAFVGTETAGVYGRVFCDFGTSFEVNDTDGETPLVIPLDRVERGISDEILFVTCLEGQQHDVSKGEEIRFIDPNGDSSEQKCTVIEVHTPLRLSIEVDKKGGSCQEWIESVNKKYVAFSRIKASKKLSFDDLAIASKKASSDASIFTPSDLGKSFDDNRRAALFACFRAASSFVGDHLRWADDNDLDDFCELVRTFMSNCESEHCFLSESQHFNVEQFLEVGRAKFSPIQAFFGAIASQEALKALTGLYHPIQQFLLYDCDEILNSPSDRTCSVNEKEGSDRNTCGLRHILGDSIVEDLQSMRVFVVGAGAIGCEILKNLAAMGIGSKSKGRVIITDMDTIEKSNLSRQLLFRDSDVGKFKSSAATQAILRFNNKMKIDSHSSKVGDSEHNPFDDLFWRKGVDIVLNALDNMEARFFTDRQCVANGKPLIDSGTLGPKGNVQVVIPHKSESYSSSADPPDPAIAVCTLKNFPYAISHTIQWGRDLFEDVFSRRPSQVNDARDSLSSTCVEAFVSRLIQERGENGFQQFAAELKEDVSPDLESSDIRAHSLEWAASTAVKLFRDSIETLLLKHPPGSLDDDGEPFWSGTRRQPRVLSFSGSVPLDAMQSSVNENLIDFVRYAARLRAEMYASKPIRDPFEFSRNDAEASLNSAEQAQPSDKEVMDTDTVNVLIDSLRRLSSFSKPLNTAEFEKDDDSNGHIAFVTAASNLRAMSYGIPPVNRLQTRRIAGNIVPAVISTTAAVSALSCIELVKLAQGAQLKLHRNAFMNLALPFFAFTSPLPAEVMPGLQGRQYTIWDRLKVRESKKALAKGGISLRKLIRRIKQLASTNPKKVSVLSISFGPYLLYASFLHDDDKNHLKSSLWNILEELTEVDDDFVSTRSNDNRSTEYSPTQKFVDLSVIVEDPDNGSECELPLVRVFRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYH0</accession>
    <name>B7FYH0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_35424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000610">
        <property type="protein sequence ID" value="EEC48724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002179738.1">
        <property type="nucleotide sequence ID" value="XM_002179702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYH0"/>
    <dbReference type="STRING" id="556484.B7FYH0"/>
    <dbReference type="PaxDb" id="2850-Phatr35424"/>
    <dbReference type="GeneID" id="7200420"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35424"/>
    <dbReference type="eggNOG" id="ENOG502SMZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_895642_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYH0"/>
    <dbReference type="OMA" id="ARTELMC"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="311" mass="34098" checksum="86D1482EE9E893A1" modified="2009-02-10" version="1">MALIATNVYTKATGTMQPTNRPNISIGMLEIICWAAAATTAAALLVCGATSCASRASFGALHTSTIANALSIQWQGGNHVEPTFIHGNVTILARTDRYVVVAKPPTVVCHHSEWTGSRSDPFQIPMLQRTREAMGGNCVNLVHRLNWGCSGCLLLTYAADTADAEIYIPNTTATLIASMKETASLKTYLALVRGEGLLQGRDFKQEGWFKVDRPIKNEKGILNNATTWFRFVAGQDNDSGRINQPRASLVLARPETGRWHQIRRHLNGLSHPILGDTSHGNSHVNREWRDLRGMPAQRTCLHLARLQLGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B7FYU0</accession>
    <name>B7FYU0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_45830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180228.1">
        <property type="nucleotide sequence ID" value="XM_002180192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FYU0"/>
    <dbReference type="STRING" id="556484.B7FYU0"/>
    <dbReference type="PaxDb" id="2850-Phatr45830"/>
    <dbReference type="GeneID" id="7200943"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_45830"/>
    <dbReference type="eggNOG" id="KOG1610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708773_0_0_1"/>
    <dbReference type="InParanoid" id="B7FYU0"/>
    <dbReference type="OMA" id="FRIADGM"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="390" mass="42822" checksum="AC0F7CC97E9DF0DD" modified="2009-02-10" version="1">MVAPPGPAVQKLNSVLHRDPFSSITYAVFWSLVLLVGAPLAIVVLQLQLIVRLLLWVTGQTGKSHYSPRTQSKLEMAVVVTGCDTGFGTEIAFWAAQAGFHVFAGCLLKESFGQFENCPAIKPIQMNVCNDNDVQEVVKQVVTWLDGGGEKKKQRVLHALINNAGIGDGGLIDWLDISVFQRNMDVNCFGMIRTCKAFLSIFKQQAIDGSHRGGRIMNLTSMAGLCPPMAAMAAYAASKHAANVFTRGLRNEMAGFGVQVCSLNPSFHKTPLVTGMQNNITSVYNGLSPTLRNQYGSDYFDTLKISLVDIPHSWSWNTNVVAEQAVSLLEINQLPAEVPIGLDGRFALLILRMIPGWCIDLVNYMFLPTPQSMRDPTKKKLQSHHGEKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZC2</accession>
    <name>B7FZC2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHATRDRAFT_35818</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="CM000611">
        <property type="protein sequence ID" value="EEC48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180125.1">
        <property type="nucleotide sequence ID" value="XM_002180089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZC2"/>
    <dbReference type="STRING" id="556484.B7FZC2"/>
    <dbReference type="PaxDb" id="2850-Phatr35818"/>
    <dbReference type="GeneID" id="7201037"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_35818"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_3_1"/>
    <dbReference type="InParanoid" id="B7FZC2"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEC48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="121" mass="12898" checksum="684049EBF22ECC09" modified="2009-02-10" version="1">MAALALLSSGQIPLTTFQAKVYHALVKVPEGKVTTYKELGLAIDCRSAQAIGQALKRNPYAPTVPCHRVVQSDLSLGGFGGTRSGAKIDRKIALLQSEGVRLNGNGCIEKSSVYTFPKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FZY0</accession>
    <name>B7FZY0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_46067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180580.1">
        <property type="nucleotide sequence ID" value="XM_002180544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FZY0"/>
    <dbReference type="PaxDb" id="2850-Phatr46067"/>
    <dbReference type="GeneID" id="7201313"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_46067"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543462_0_0_1"/>
    <dbReference type="InParanoid" id="B7FZY0"/>
    <dbReference type="OrthoDB" id="47267at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002852816" evidence="3">
        <location>
            <begin position="22"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="502" mass="52747" checksum="26B0623B08B841D0" modified="2009-02-10" version="1">MHFSPQVFLFIASFWGPAVDAHGYLKSPRSRNYVAAEDGVGYGGTSSDPQKEFCPQCLNIGGTLAACGLLSNTNYDFPPSAVGGVMPANIQGTFPKGGEIDFDVVLTAHHKGHFNFYACPVVPGIAPTEECFKSHPLEFVQDLLYGAPKDSNYPSRAYIPPLTYEPTLIATDGTVPGAFYRYRMKLPEDIQGDLVLLQWHYLTANSCKHDGYDDYAFPSEWPNPGYAGLPDCGIIPSDGIGGPEQFWNCAEVAISSNGGGVTAPPTTPAPVPAPSASSATLAPYVAPSPTASMVSPTQSPVGDANGGVAGTCGDGNIGNGICPDSALCCSRFGHCGSTAAYCNDGPVVTVAPVSTPTSAPVVATQTSSPTVDSPANWTLSTESRCGVSELDARGNCGSVCVGSNDCGVGEWCWSVHANYCDNARPGFVICPDLSRATTTPRCGVDELNARERCGPTCGVDQDCVDGEMCWGVHANTCDCTRDEGNGRNRNRNVRVLRHGNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0G0</accession>
    <name>B7G0G0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Pt-KIF-1</name>
        <name evidence="9" type="ORF">PHATRDRAFT_2418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180469.1">
        <property type="nucleotide sequence ID" value="XM_002180433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0G0"/>
    <dbReference type="STRING" id="556484.B7G0G0"/>
    <dbReference type="PaxDb" id="2850-Phatr2418"/>
    <dbReference type="GeneID" id="7201179"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_2418"/>
    <dbReference type="eggNOG" id="KOG0241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309401_0_0_1"/>
    <dbReference type="InParanoid" id="B7G0G0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="340" mass="36902" checksum="BA6E91A6E81A9B68" modified="2009-02-10" version="1" fragment="single">PSTPKAKPNSSRPSVPITRLVAETTTTSFSSPSSRNFDFDAVLPPDATQSDVYRATVGDSVSRNAFAGYHTTILAYGQTGSGKTYTMMGAPRLNDGDGVIPRAVHDLFRTRQLQCAQGKIVSMDLTYLEIYNDELRDLLSETMQGETTILSPSSSTLKLRDHGSNTAEGIVVQGLTRVAVDSMADVHTYMEQAHRNRTTGSTRLNERSSRSHAICTLTVTTKTTSASRSGAHSTNTTRAKLTLVDLAGSERIKETGVVGLQQQESININKDLFVLGKVVSALSQETKGHVPYRDSKLTRLLRDSLGGNCCTVLIACVSPADMHVEESINTLRYAERSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B7G0I1</accession>
    <name>B7G0I1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_36142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000612">
        <property type="protein sequence ID" value="EEC47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002180481.1">
        <property type="nucleotide sequence ID" value="XM_002180445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G0I1"/>
    <dbReference type="SMR" id="B7G0I1"/>
    <dbReference type="STRING" id="556484.B7G0I1"/>
    <dbReference type="PaxDb" id="2850-Phatr36142"/>
    <dbReference type="GeneID" id="7201188"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_36142"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="InParanoid" id="B7G0I1"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35085" checksum="32652796C8AFAC7B" modified="2009-02-10" version="1">MSVVFATAGYDHIIRFWEAPSGICSRIIKYPDSQVNRLEITPDKQFIAAAGNPVIRLYEILEPSAMGGDERDQQAVLTLEGHGSNVTSIGFHKDGRYLYSGSEDGTIKVWDLRSPSYSRSFDVGAGVNSVTLRTDRDQFVSGDQNGYVKIWDLGGNGCINSLKPRSAEGTVPIQAVDISEDSRTLVAVSNHGSVFVWDPTSSVGSEDDNSTMRPVKKFRAHPPGTYCLHGKIAPDCRHLVTTSSDGTAKLWDTATWELTHTLQNQKWVWDAAFCADSSYLVTASSDHVARLWNLQKGSVVRQYHGHQSSVTCVALNDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B7G251</accession>
    <name>B7G251_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181316.1">
        <property type="nucleotide sequence ID" value="XM_002181280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G251"/>
    <dbReference type="PaxDb" id="2850-Phatr47008"/>
    <dbReference type="GeneID" id="7202241"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47008"/>
    <dbReference type="eggNOG" id="ENOG502SDRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1484691_0_0_1"/>
    <dbReference type="InParanoid" id="B7G251"/>
    <dbReference type="OrthoDB" id="41517at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855735" evidence="1">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="246" mass="28207" checksum="55AC983AAAF742AB" modified="2009-02-10" version="1">MRSTFAKRQTLYSLLLMSSLLSRSCSFLITGSNLYSLTLRNIPTCMSYSYRNIGDLGNSFNADEAQQLRERLLELKVNMIEEEYRRPPNPELSPQRFVSELLKGLYYNADPLPDSGFRLLLRASTSRWRSALYRSVAAPLSAGEEAVASALGQAIVRPRNQFAIIAGEAEDYEISFPTDTLDYADGTCWVECRLRDNCDRLLVVMGWQLEQRKSDGSWLVDNIDWQDFRDEFRPGIGREEWMRICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7G266</accession>
    <name>B7G266_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181325.1">
        <property type="nucleotide sequence ID" value="XM_002181289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G266"/>
    <dbReference type="PaxDb" id="2850-Phatr47019"/>
    <dbReference type="GeneID" id="7202250"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47019"/>
    <dbReference type="eggNOG" id="ENOG502SGCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428684_0_0_1"/>
    <dbReference type="InParanoid" id="B7G266"/>
    <dbReference type="OrthoDB" id="41850at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="772" mass="84458" checksum="C2A6D886183544EB" modified="2009-02-10" version="1">MNARSWAQEATAWYVAHSDPYTSHQDNVHQVLRCPVVALTLSILHQSVGSDPNCQVLADEKNGAASGITVRATVPPSSDESSSKHSGTVTTSPDWRAYLAQETDTGVLEFNQANEEAYDALSRRTKARLEAFLTGTSLAVATTVPTAATEDEIVGSSHASNLALSRPPMFPPKPNMATGKPIRGYSNRTTSQESDRSLGLIDGLAGFHRFEHSNSSSSAPSRSSPVLSSLNAGSQTLLRSISASTTSSASNIQKISKQPQIAPDELTIRMELYIRALLRVSAQQQECVLGAEPARALKARARSIVIALVDTVGTIRQQSPVLTRLLSWHVKELLAVDVLGESVVRLIRKVVSDYEHKTSFASLAFLSSPDDTAEHSLTPMVLWLFQYLQTSWRDCVSDCELERMLKLSLPENLRSVFKTIEFRSIGHLLETCQEYRDVLQHIELAPGIRSYDDSDDADHSSTEANFRSACSSIAVHNNKAIRQAIRDLQREVITVNGNVLPPVTSRIELVHLLSQTLNSRSLQTAQPRLTRSQRRKQRAVRRVESAPILSTSESEADTAGPVLDSDGFLSSGNEGDLSDHKRQTSRAVGAGPSSKPTRRRRNFHLSTVDFLTKRLLLAAGRTGTGGDAYFVVRDLFGGDDIEVVPSHLPPSHARMVRPGSIEIIIMLSSVTIKCHGSFDVYPTSLVGDCEPLIQLHTTTTEVIQLQEVRASDSSGDDIKADNFSSEDESDAPGGRQGSVMVIQERQTERTGWRTLSIRPALYEKVESYSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2G5</accession>
    <name>B7G2G5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181375.1">
        <property type="nucleotide sequence ID" value="XM_002181339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2G5"/>
    <dbReference type="PaxDb" id="2850-Phatr37218"/>
    <dbReference type="GeneID" id="7202017"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37218"/>
    <dbReference type="eggNOG" id="ENOG502SKKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002237_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2G5"/>
    <dbReference type="OrthoDB" id="43862at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="72759" checksum="9C7AD0807D4A1374" modified="2009-02-10" version="1">MSPSATLKTSNNDLINHITSLNLSVVPSPPSTMTSTIADTFCTGHYITVSCPHFNRQPAASPLSVRVPNGATLRSSHTATLDLPGFSPAACQAYIFPGLASHPLISIGQLCDDGCTATFSATRLDIYRDTTLLLTGARAPATGLWHLDLTPAKTAHALIPDSSLADRIAFVHASHFSPALSTWCTAIDAGRLPTFPDITSKQGRKYPPLSMATIKGHLDQQRANLRSTKPSSVPPVALPNPLHESQLDFCPAPATPPAGRTHHVFAAHQRVTGQIYTDQPGRFLTPSSTGHTDMLVLYDYDSNAIHVELMKSKSGAEILAAYQRAHSLFTQRGLQPQLQRLDNEASPALESFMTANQVDFQLAPPNLHRRNAAERAIHTFKNHFIAGLCSTTPDFPLHLWDRLIPHALLSLNLLRGSRINPTLSAHAQLHGAFDYNRTPLAPPGTRILVHEKPAVRETWAPHAVEGWYLGPALHHYRCHRVWITETRAERVANTLAWFPSRIPMPTASSTDRALATARDLVRALQNPSPASPFAPLDATQHQALLHLADLFASVAAPASPTAAPTPAPPVPAPPPAQVRFAVHIVTAEHAPALPRVPILAPPAPRVLSRTRNPGRRRRKARKQPPTPTLVPAHPHNTRTRPFLVPASANAVVDPATGASLEYRHLRTARVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2P9</accession>
    <name>B7G2P9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181419.1">
        <property type="nucleotide sequence ID" value="XM_002181383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2P9"/>
    <dbReference type="PaxDb" id="2850-Phatr37300"/>
    <dbReference type="GeneID" id="7202057"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37300"/>
    <dbReference type="eggNOG" id="ENOG502S9I4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740734_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2P9"/>
    <dbReference type="OrthoDB" id="5876240at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="233"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="42779" checksum="36FD7A8DCAA663EE" modified="2009-02-10" version="1">MPVRDPRLRIGGKVTAKACHVVHLSECARRYGINKHSKRLVGTVLDVTTTPVSITTGRTSTLITAVYDFGESLFKEKTLNIRSVKAFVLPEDEGMSLIEEIAAETLQTAEADMEAGNLMEESVEAPVAEMVETPADIEPNTLVDTEPNTPVDTEPNSPVAEIVETPVDTNTLVDTESKNPVATVHQTEWYVNERKTRLDVNGHVYVRHFHIRTSVGDLIGQDSDNGVRFSRLEYFLLMFPPTQLTTMCWLTNTMLAQQNKHTITAGELLWFFGILILTTKFESSSRAQLWSTTAPSKYIPAPSFGHTGMSRQRFDNIWKHICWSEQCPVQPEGMSTHVHQWQLVDNFVTRFNEHCSENFVPSHLICVDESISRWYGQGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G2U3</accession>
    <name>B7G2U3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000614">
        <property type="protein sequence ID" value="EEC47367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181444.1">
        <property type="nucleotide sequence ID" value="XM_002181408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G2U3"/>
    <dbReference type="PaxDb" id="2850-Phatr47200"/>
    <dbReference type="GeneID" id="7202189"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47200"/>
    <dbReference type="HOGENOM" id="CLU_2282917_0_0_1"/>
    <dbReference type="InParanoid" id="B7G2U3"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC47367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="102" mass="11132" checksum="CD03CE29D368576B" modified="2009-02-10" version="1">MVFKKLRKTMGRRKAGKDAPAAAEAVQKNDSIDEDFPQDETLAAAESREEAPVPVKEADNEPASETAEASEESDEQERATPDNLEQEAQEDTYIGCCGINCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B7G380</accession>
    <name>B7G380_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHATRDRAFT_47390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181740.1">
        <property type="nucleotide sequence ID" value="XM_002181704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G380"/>
    <dbReference type="STRING" id="556484.B7G380"/>
    <dbReference type="PaxDb" id="2850-Phatr47390"/>
    <dbReference type="GeneID" id="7202437"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47390"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291614_0_0_1"/>
    <dbReference type="InParanoid" id="B7G380"/>
    <dbReference type="OrthoDB" id="37582at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEC46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="668" mass="74072" checksum="777D4FF9002FEAF5" modified="2009-02-10" version="1">MPDRRESRRAVDAMAWILVLAGLYWFAASFFLAKRSLSQVSSCDEARVLLYETLKLGQTSGTGSVVQRRLDSILSSSASRRGGCWMDRVVDSMVFIVVDALRFDFALYNLPKSIGKRLDKAKHHASISKVADHTILTASATSYSKLYQFVADPPTVTMQRLKALTTGGLPTFADISSNFGGGTVDDDSWIRQVLLERNWERRGLSRNTKAAFVGDDTWDDLFPNIFTESYPYPSFNTRDLDTVDNGCLSHVPDLISRLRHSENSNETTTTGNDDDLELVVVHFLGVDHVGHTYGPHNQHMDAKLRQMDDALASVLDFLDSSDSCHAAMILGDHGMTEDGNHGGGTEEEVNAALFVHMSATCHVRESDKNDGPSRMDAGFLDTSRHSDLVQAAFSSIHQIDLVPTLSIMLGIPIPYANLGSLVPSLIPSQSIAAITTALALNAAQVWRYFTFYSNTANKLPGLPELESKLAMGIKMFEDALHQDDPEADEYFQAATLFKFYLREALELGQRVWTRFDDTGMTIGIIIITIGLICYAAPLVRPEKVRLLPSSQFWEVSVTTVFMVFQCGLLTFSNSYILEEQHTIMFCLTIVSVILALRIRRESAHDIMWRAVLLLPMASRLNEFFVFGHGMDPSTGLYAAHKTDHSVPLDYFGGLCGTALSCEELVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G386</accession>
    <name>B7G386_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181744.1">
        <property type="nucleotide sequence ID" value="XM_002181708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G386"/>
    <dbReference type="SMR" id="B7G386"/>
    <dbReference type="STRING" id="556484.B7G386"/>
    <dbReference type="PeroxiBase" id="2571">
        <property type="entry name" value="PtrAPx01"/>
    </dbReference>
    <dbReference type="PaxDb" id="2850-Phatr47395"/>
    <dbReference type="GeneID" id="7202539"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47395"/>
    <dbReference type="eggNOG" id="ENOG502QS7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_2_1_1"/>
    <dbReference type="InParanoid" id="B7G386"/>
    <dbReference type="OMA" id="PIKEKHA"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855780" description="Plant heme peroxidase family profile domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="5">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="331" mass="35679" checksum="03C9B99B16F139AD" modified="2009-02-10" version="1">MKFTSFAFLALAASANAFTQPASFGAARSFSTSLDVSKKDLEGAQTMIDKIIDDTNANPVFVRLAWHDSGTFDVNVEKEWPASGGAIGSIRFDPEINHGANAGLSGAVKLLEPVKESFPDVSFADIFQMASARSIELAGGPKIDMKYGRVDASGPENCSAEGNLPDAEPGPDGKYGGPGGSASTEDKTPNGHLRKVFYRMGLNDEEIVALSGAHSFGRAYKDRSGLGAEKTKFTDGSKQIRADGKEAKYNPGGSAWTKNWLVFDNSYFTTIPDESADPELLKLSTDKTLFGDEDFKPFAEKFRDSQDEFFASYAKAHKKLSELGSKFEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3F7</accession>
    <name>B7G3F7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_47458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181780.1">
        <property type="nucleotide sequence ID" value="XM_002181744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3F7"/>
    <dbReference type="STRING" id="556484.B7G3F7"/>
    <dbReference type="PaxDb" id="2850-Phatr47458"/>
    <dbReference type="GeneID" id="7202474"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47458"/>
    <dbReference type="eggNOG" id="ENOG502SQZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_0_1_1"/>
    <dbReference type="InParanoid" id="B7G3F7"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="473" mass="53192" checksum="0D5931CA676DEBA2" modified="2009-02-10" version="1">MKPGGQRQRRKILSEEEYTQTLSQIIQRDYYPDLSDLERQAALQDRRSVGDIEGAVAIRRATRKLQRHEESLAIQEAEQEAETDERTGLRTVARPLHQETLSGFHTRATNEDDAEFEVEQRREIDKLHARKRMLTITNGPTPDSNHRSLADSSPFQLASDEFNPSPVRVTHRLAEEENSFFFVPTPMQSHCQKTQPQLAGITFSKEQPDAPYTAATEEHTRALMPPPKRPTSNASIPSKDTLMEYIPKDRLEKQIEPSATRFPKQPLLIHLPRQHLEGSSSGSITEYTTDASTDIDSPAYPSLETDLLKGMKRRRREQASFVQMTPLIVPGAVGMNDSPITTWGTVANTPTLLETTKLPQAFQFPKVSERDEAASKARAKLDERVRKSLAASTPLLSKTALALLKRPSRPMSARSRSALGSALRISYTPLQQKRSGRDTTYHITPRTKSNLVSDKTNKKDQKSITDGLLKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3J2</accession>
    <name>B7G3J2_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_37714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181624.1">
        <property type="nucleotide sequence ID" value="XM_002181588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3J2"/>
    <dbReference type="PaxDb" id="2850-Phatr37714"/>
    <dbReference type="GeneID" id="7202595"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37714"/>
    <dbReference type="HOGENOM" id="CLU_060859_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3J2"/>
    <dbReference type="OrthoDB" id="44984at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="269" mass="31646" checksum="D0602062BEC82952" modified="2009-02-10" version="1">MSYNQHVTLIRDLYKNFSVHDDRIARGIKCPLDLENTKLAMPNYQWLFPRTNYIVGIRHPVLWFESFYNFRIHNRFSMPPPGDLVGRCRRGGFNVCTFRGNFHLFLSNLGKTHMATDPDEQQYLAPEFRHTRDPIVKLPGKTPQKIFLYEVSQLSDPDPDRAADLRTTLQSFLNLTIPLDPMIWYRPGKQHKNQWELERLNAKKINICDAQHEALRTVLRYQAGNASRWIRHYFLDAPDVVTSSKEYLRNIILPSWERDPCLDRALSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B7G3Y4</accession>
    <name>B7G3Y4_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000615">
        <property type="protein sequence ID" value="EEC46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181688.1">
        <property type="nucleotide sequence ID" value="XM_002181652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G3Y4"/>
    <dbReference type="PaxDb" id="2850-Phatr47315"/>
    <dbReference type="GeneID" id="7202387"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47315"/>
    <dbReference type="HOGENOM" id="CLU_541305_0_0_1"/>
    <dbReference type="InParanoid" id="B7G3Y4"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013402132" evidence="2">
        <location>
            <begin position="16"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="504" mass="51776" checksum="19C25D9FBD9D01A0" modified="2009-02-10" version="1">MRIVRLGLLLEAVMAWDAAWFEADHGLSLDRSLGDPSASSPIHPVRHLKASKKSKSSDRPGKGSMFKDLSAKDSSGKEAAGKGSSTKSQKSVAPSPHPKSFPVSPTPSPTETFVEPPTVAPEEMPTFNPVYSPIDVPTQVPASAPTATPVDIPTTVPIEAPTVTPVDVPTAVPIETPTETPVDVPTTVPIEAPTETPVDLPTTVPIDAPTVTPVDIPTTVPIDAPTQVPVAAPTETPEATPTAVPIDTPTQIPTGVVNPTDVCALAQEISAEDCINTAERLQMDIENNLSGVICDQTFIGITETIVIPENASFGYRCEVPGRCVIQGDFNTQLFRTESTGSANNGHDICFSGIQFWDGSSDPSDPVPDGGAFGLVGGTTSFVGPGCRFLNNTANSGSGGAIAVSSQGAVSVIGCLITENAASESGGAISAFNVGPSLNPEVTIINSFFFANTAPLGPDISAGDLIDSGSALVTCSANTTFCAPATTFARSGATISGCDNVELCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B7G410</accession>
    <name>B7G410_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_37779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181991.1">
        <property type="nucleotide sequence ID" value="XM_002181955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G410"/>
    <dbReference type="STRING" id="556484.B7G410"/>
    <dbReference type="PaxDb" id="2850-Phatr37779"/>
    <dbReference type="GeneID" id="7202761"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37779"/>
    <dbReference type="eggNOG" id="ENOG502S48R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379248_0_0_1"/>
    <dbReference type="InParanoid" id="B7G410"/>
    <dbReference type="OrthoDB" id="46691at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="356" mass="39785" checksum="50DF247DEB71DACD" modified="2009-02-10" version="1">MSRIPLELQAIFVASNKGEEVHKPPSNRAAFKVFKSIFGGFGRRKRSTENKRENLKRIASQSSFATVSTLGVDDFSGSSHNENNECAPVTPHEHLEVLLKARGYCTERYSVLQTAFFNRPTPLQLASYDTKLIQLIKSQDEQKVREILASGISPNACNIHGESLIHKACRLGYHRLVRAFTDFGADLAISDAQGRTLLHDTCWGARPSFQTFSLIVDRQPELLFLADCRGACPLEYVRKDHYVFWIEYLDQIADKYWPSTQSTPKLSYLVKQEPHSRQIGEPGNALSLELAAMVASGRLSPEEATYLAKGDEEDSVSGEEDSLSDDDESTWNEEDNEDDELLADLCGIHSLSSIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G420</accession>
    <name>B7G420_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_47547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
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            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181995.1">
        <property type="nucleotide sequence ID" value="XM_002181959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G420"/>
    <dbReference type="PaxDb" id="2850-Phatr47547"/>
    <dbReference type="GeneID" id="7202766"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47547"/>
    <dbReference type="HOGENOM" id="CLU_805262_0_0_1"/>
    <dbReference type="InParanoid" id="B7G420"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="38620" checksum="370B2EA7B127F2D3" modified="2009-02-10" version="1">MVGKFNVSKSVDENNSEIFWRRAFSSPQKSILERREGNLVEYDDDDDEDDSLSSSEEQGKEKLDTSFQEIFTSVNSLLQSRQTFTLHEGTSLENELKLLKRMVRRRSLSSQVSVTPTASSRIMAPKFVFDPPLVQEKSPRCHEKQSRHFCLQEKFPFRDKKILDDLSGSKDAAGQQTDEASMDLNTLKYEQQKEKLHGFLKDTLPVSLEDSVPYSPTKKKSANGWFSCSTDSDEIEIDPFSTCISPLSEEVSPLASPVAWSVSSGLSSISCSVASTSPQAYRSRKKGTGLHGAASSPTRLLLAAGMNMQRAFDQENHHGTDAAPRLPGRSDRAPRQPRRERSFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7G471</accession>
    <name>B7G471_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_47591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182022.1">
        <property type="nucleotide sequence ID" value="XM_002181986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G471"/>
    <dbReference type="PaxDb" id="2850-Phatr47591"/>
    <dbReference type="GeneID" id="7202646"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47591"/>
    <dbReference type="eggNOG" id="ENOG502QYH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726601_0_0_1"/>
    <dbReference type="InParanoid" id="B7G471"/>
    <dbReference type="OrthoDB" id="44644at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="327" mass="37316" checksum="A4854A5B65530BFA" modified="2009-02-10" version="1">MLRKLSGTAAFSSLSMGTQQTLAFFQKSRATGFDIPTVTKLGKKTRPGLLEEFSNLTGRALYDTIAALPSDTLPLGDKPLPRLFLESQTPSNNRTLVILTGDLRCGEKAWSTLYENVLDLNHADLALFVQVPSQLEYKNASLFARARHIEWIPRGVEGYRASAAIVHMFRYFVAERIKRNGWEQQYDRFIVTRTDQFYKCPIDLSKLDPESLWLAEGEDFGGYNDRFYVAPSSLIRKTLEVMPTFVRKPYIFQNVIPGRSMNSEKVLYLLWRELGLVPSVKRFVRTFFTCSMPMDSARWSKGIRMVDEGVHIKYEREYANASGVSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4D2</accession>
    <name>B7G4D2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_37903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002181892.1">
        <property type="nucleotide sequence ID" value="XM_002181856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4D2"/>
    <dbReference type="PaxDb" id="2850-Phatr37903"/>
    <dbReference type="GeneID" id="7202679"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_37903"/>
    <dbReference type="eggNOG" id="ENOG502S5TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082892_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4D2"/>
    <dbReference type="OMA" id="SHTEYRS"/>
    <dbReference type="OrthoDB" id="6352234at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="293" mass="32800" checksum="B327336536C378C3" modified="2009-02-10" version="1">MSSARPSFSLILPSIVFGLCLGSALTYSMLFLNDYTHSFSEVGIRGIAPTQANVGWHPIHVYYGDAVGLQADPSPEAWFAQVHQDEIVMDLIGNDGYFIDLAANDAKELSNTLALERHGWHGLCIEPNPNYWYGLSHRNCTVIGALVGGDTPPGSLPDKVPVKFRGVYGGMVTVMDDKMANRKKEPDAPIEYRYPASFAKVLEQFNVPSVIDYLSLDVEGAEYMILQHFPFDRYQIRIMTVERPNKQLKSLLLENGYVFLKDLVWWGETLWAHQSTGLTPDHPQIAKINTIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4H5</accession>
    <name>B7G4H5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_21829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182074.1">
        <property type="nucleotide sequence ID" value="XM_002182038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4H5"/>
    <dbReference type="STRING" id="556484.B7G4H5"/>
    <dbReference type="PaxDb" id="2850-Phatr21829"/>
    <dbReference type="GeneID" id="7202859"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_21829"/>
    <dbReference type="eggNOG" id="ENOG502QUUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_0_0_1"/>
    <dbReference type="InParanoid" id="B7G4H5"/>
    <dbReference type="OrthoDB" id="414267at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000003">
        <property type="entry name" value="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050088">
        <property type="entry name" value="IspD/TarI_cytidylyltransf_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32125">
        <property type="entry name" value="2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32125:SF4">
        <property type="entry name" value="2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEC46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="271" mass="29796" checksum="32E453C3D2E1D2C6" modified="2009-02-10" version="1">MCRESLAATDAENNGTSNTVAMDDVGFVLLAGGTGSRMKATMPKQFLELRGVPVLHHSLDLFLERLPEHLKAQNKAPPPYVVLVMDPIYQEEYQAIVNRYDGRLVFANPGVERQGSVENGLNKLVEVSNGNCKYIAIHDSARPLVTIPELCKVVHDAKEYGAAVLGVPCKATIKETEDGSTVLRTLPRARLWEVHTPQVIKIETLQRGFVKVARENLEVTDDVSIVEALGEPVKLTLGEYTNLKITTPEDMDVAEAILEERKDSPVSLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7G4M7</accession>
    <name>B7G4M7_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHATRDRAFT_3425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CM000616">
        <property type="protein sequence ID" value="EEC46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182101.1">
        <property type="nucleotide sequence ID" value="XM_002182065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G4M7"/>
    <dbReference type="FunCoup" id="B7G4M7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G4M7"/>
    <dbReference type="PaxDb" id="2850-Phatr3425"/>
    <dbReference type="GeneID" id="7202896"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_3425"/>
    <dbReference type="eggNOG" id="KOG2805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7G4M7"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="394" mass="43638" checksum="A9A541F309C31519" modified="2009-02-10" version="1" fragment="single">RVVLALSGGVDSAVAAALLQETYGSSNNSDIGSAVLQTVHMSNWNSNTQDDDSIASCTSEQDWKDATAVAEHLRLNLTRQHFEREYWNQVFEPYVNDILRGTMGNPDIGCNVHVKFGALREFADWVLRWGWDQPPSPHYSHHNHQYQTPPPLLLAAADPSKDQSYFLSACAGYQLSNVLFPLGEYYKKENPSNDGKPTVRQLAKDYNLPNANKRESMGICFVGKRQSGFGDFLHEYLPHPLRPLQFVDVDTGAVLPAPTPKNAHAVLYTIGQGAKISGASEKYFVVDSDVAQNRVLVCAGTHHPALYADSLVLETVYWTAGEMPGPLQKRGRLRLQCRIRHLQPLIDCELRVELDGSLTVYFDKAVRGITPGQTAAFYALDGLLCLGGGPIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5B6</accession>
    <name>B7G5B6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein fucoxanthin chlorophyll a/c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lhcf10</name>
        <name evidence="19" type="ORF">PHATRDRAFT_22006</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182219.1">
        <property type="nucleotide sequence ID" value="XM_002182183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5B6"/>
    <dbReference type="PaxDb" id="2850-Phatr22006"/>
    <dbReference type="GeneID" id="7203170"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22006"/>
    <dbReference type="eggNOG" id="ENOG502S3EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057943_4_1_1"/>
    <dbReference type="InParanoid" id="B7G5B6"/>
    <dbReference type="OrthoDB" id="405870at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000011">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012564986" evidence="18">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEC46120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="199" mass="21353" checksum="379F982DA0359078" modified="2009-02-10" version="1">MKTAVLASLIATAAAFAPAQKAVTSTALSASNFEDALGAQPPLGFYDPLGLLDGASESKFERLRYVELKHGRISMLAVVGYLVTEAGIRLPGNIDYSGTKFTDIPGGFDALSAISKEGLGQIIGFIFFLEMIMRPIGGRGEFVGDFRNDAIDFGWDTFDEETKLKKRAIELNQGRAAQMGILALMVHEQLGVPIIPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5F8</accession>
    <name>B7G5F8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_47941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182406.1">
        <property type="nucleotide sequence ID" value="XM_002182370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5F8"/>
    <dbReference type="PaxDb" id="2850-Phatr47941"/>
    <dbReference type="GeneID" id="7203130"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_47941"/>
    <dbReference type="HOGENOM" id="CLU_697308_0_0_1"/>
    <dbReference type="InParanoid" id="B7G5F8"/>
    <dbReference type="OrthoDB" id="47761at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="151"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="381" mass="42768" checksum="D91A1CBF4B45F0DA" modified="2009-02-10" version="1">MERSGSVEDFPPTFVSYRSEYPREESYRCMMNNRTPNSVSPPDFLKIPCYRPVPRKGFSSHHDSSCHPGFYAGNHSANVPHYATQAAPSFDSTGSSHGGHYTPPPPPPPVLSNINPHSHSYPPPYHGGYQYYAPWPNTPPPEYVTDIQPEDVLSGRGGATNSHSGNRAFRTLVKDFQERYLKAKKRDKPSVASLVVELVRQKGGRFLRRMGTDSDGQVLWIDIGDERAREKTCQALREGAPLLRRSRHTPRSFDDVVDAKLHDSIKENDSFETPSSTSSIVRVVQDNENWMKGSIFSSSKDHDINDGPIVIRPMRRLLHRRSVAPIPLDQLSPQDRDLYLRDFLPPCPSIGKQSNIAAEPTASPSHHPVEYVEKPNPRATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5N3</accession>
    <name>B7G5N3_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_14518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182278.1">
        <property type="nucleotide sequence ID" value="XM_002182242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5N3"/>
    <dbReference type="STRING" id="556484.B7G5N3"/>
    <dbReference type="PaxDb" id="2850-Phatr14518"/>
    <dbReference type="GeneID" id="7203239"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14518"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_1_0_1"/>
    <dbReference type="InParanoid" id="B7G5N3"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC46179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31519" checksum="6526238D3F5444C0" modified="2009-02-10" version="1" fragment="single">MNPNLSQLVLRSQLIRVMEGLEHFVQLDLLELYDNQVEELACLGDGEDGAPGKTLRVLDMSYNVIRDMQPVMFCPNLQELYLANNKLRNMAGLGSLTKLRKIDLGANRIREMDAAELAPLVHLEELWLGKNKIERIEGLSTLKKLRRLDIQSNRLTQVENLTSQTETLEELYLAHNGIATEGTILPSGLGQTFELLNVLDLSRNRLTQVNQLGHLKSLEELWLSGNKIATFDDVQNLSSLGESLQTVYLEYNPLQEDPLYRKKLAELIPSLSQIDATLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G5P5</accession>
    <name>B7G5P5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_14646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000617">
        <property type="protein sequence ID" value="EEC46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182286.1">
        <property type="nucleotide sequence ID" value="XM_002182250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G5P5"/>
    <dbReference type="PaxDb" id="2850-Phatr14646"/>
    <dbReference type="GeneID" id="7203012"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_14646"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_1_1_1"/>
    <dbReference type="InParanoid" id="B7G5P5"/>
    <dbReference type="OrthoDB" id="44517at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="142" mass="15255" checksum="CF9D3C0509C12638" modified="2009-02-10" version="1" fragment="single">PSIVDVVSGTADFSTLVRAIVAADLVDTLSAPGNFTVFAPTNAAFEALGTTLDDLINNENKEPLRQILLYHVVPAKALFSDLEDDSTLTTAQGSAIAVELRYFLWFVTGARLNGDARITDRNIETSNGVIHVIDKVLIPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B7G642</accession>
    <name>B7G642_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_38525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182658.1">
        <property type="nucleotide sequence ID" value="XM_002182622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G642"/>
    <dbReference type="FunCoup" id="B7G642">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G642"/>
    <dbReference type="PaxDb" id="2850-Phatr38525"/>
    <dbReference type="GeneID" id="7203485"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38525"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_0_1"/>
    <dbReference type="InParanoid" id="B7G642"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="519"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="665" mass="73748" checksum="CD8B204BFD3DD6A8" modified="2009-02-10" version="1">MPEEESKKRPRDNIAESESLKTPKRFWNREIPSSSHYHVSWMHAQTLTAVVTSTKYGYVVSASQDGTVKFWKRLEVDGEPVEGQHPCLEFAKSFTAHAGPVLALAMDPDEGVCASVGADNVIKFYDVSTFDATAMIRTERPLGTACCWLRSANRSETLLAVGAADTGDIYLHAPDRSRVVQTLTMHGSNIVTCLAYNATHHCVVSTDQKGIIEIWDSWGTPDVSERTSDADEGTEDEKFALLVGGPLVPSRHGIVYGSKVDTQLYELVRKKTFATAIAIEPTGEHFAIYGSDRKIRIFEHRTGKVRVTYDERLKAYDRIFGNSPFHLDTIEYGQRAALEREMDAESTVYSAGMALSKSAPVGCAPQRIAFQFDGSGKYLLIPALVGIKVIEWRKNKLVKMIGQADASQMRFLSICLCPGDAKVNRQLQLSRNASKKTSAATEADEIERASDVLLVALAYNQRRLYVFSQLDPVDDRDAPDNVLVRRDVWNEAPSGQDQIHTESRHTNTTSQASRAVIRTTLGDIHLQLFSQVPKTIENFVGHAKSGYYDNVIFHRIIKGFMLQTGDPLGDGTGGESIWGGEFEDEFVPGLRHDRPFTLSMANAGPNTNGSQFFITTVPCPWLDNKHTVFGRVTRGMDVCTVIENTKTDESDKPLADVQIQSIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B7G678</accession>
    <name>B7G678_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_48167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC45963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182676.1">
        <property type="nucleotide sequence ID" value="XM_002182640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G678"/>
    <dbReference type="PaxDb" id="2850-Phatr48167"/>
    <dbReference type="GeneID" id="7203503"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48167"/>
    <dbReference type="eggNOG" id="ENOG502S3ZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062943_0_0_1"/>
    <dbReference type="InParanoid" id="B7G678"/>
    <dbReference type="OMA" id="GNFMGYS"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44767" checksum="007383C5D99786D9" modified="2009-02-10" version="1">MAASIFDGCSDTCGWIAAVLAVLSFGSFGVPIKLAGKVEVHPLVMQSYKTSVCFLTCWLVILLGEEPRWTPYGIVSGLFWVPGAAMGIFGIRNAGLAVAVGTWSSITVLTSFFFGIIVFQERVKSFYQTCLAFGCLIIGLIGMSRFSAHQQQVDTLAVSYRSVKTAASHPLGLGQKLKRAGSTIAENSITVPLVGASGVIPMEIEPFATDGEDIVMGTYDDAKSVLSKDRLVLFGGRVSLTRRQMGILGAVINGAWGGMNLIPLHFALQEEDMTGAGYLISYATGSLIVNTCIWLAFLGYYLHQTNGHWNEAVDCLPKWHFEHLLIPGLMAGLLYSFGNFCSILAVTYLGQGTGFSFCQMQLFVSGLWGVFFFKEVQGTDTITKWFISASVAVLGIVWLAHEHEGGSGMHRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7G6I8</accession>
    <name>B7G6I8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase ERG24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHATRDRAFT_48260</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000618">
        <property type="protein sequence ID" value="EEC46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182735.1">
        <property type="nucleotide sequence ID" value="XM_002182699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G6I8"/>
    <dbReference type="STRING" id="556484.B7G6I8"/>
    <dbReference type="PaxDb" id="2850-Phatr48260"/>
    <dbReference type="GeneID" id="7203365"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48260"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="InParanoid" id="B7G6I8"/>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016129">
        <property type="term" value="P:phytosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902652">
        <property type="term" value="P:secondary alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEC46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="467" mass="52403" checksum="5972E525DF5CC4DE" modified="2009-02-10" version="1">MTVATAVPRQQNRAAAAFEYEFGGPIGATLTTLALPLVVLVLAHWSDVGRVDFAFLSASLGDTTNSHDPKPFWQIIRQNSVLCPRCNDSDSVSLLLRCALGVVAWFLFQVLLERFLPCELVQGSPVKGDAKNRLTYRINGHLAFWVTLLLVHAAWPVWDANAALYQFTTAPLATLYKYYTELAFVTILLSAMASTGLYLDSFRGQHKILADGGDSGNVLYDFFIGRELNPRIGTFDWKEFCELRPGLIGWVLLNIACAKQQYSVLGYVTGSMILVNVFHGIYVWDALYQERAILTTMDITTDGFGFMLLFGDLAWVPFTYSLQARYLVKHDPNLSAVALAGIVALHILGYLIFRGANGQKDAFRRNPTDPALSHLTFLQTKRGTKLLTSGWWGMARKINYTGDWIMGLTWCMVCGFDSAVPYFYAVYFFILLVHRSIRDDHMCSVKYGDDWETYKSIVPHRFVPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B7G783</accession>
    <name>B7G783_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETFB lysine methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein N-lysine methyltransferase METTL20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_38927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. ETFBKMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182986.1">
        <property type="nucleotide sequence ID" value="XM_002182950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G783"/>
    <dbReference type="PaxDb" id="2850-Phatr38927"/>
    <dbReference type="GeneID" id="7203752"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_38927"/>
    <dbReference type="HOGENOM" id="CLU_928945_0_0_1"/>
    <dbReference type="InParanoid" id="B7G783"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050078">
        <property type="entry name" value="Ribosomal_L11_MeTrfase_PrmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC45722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="300" mass="33669" checksum="429E2FD51B870041" modified="2009-02-10" version="1">MRLALSTEEPEFDLDVLFEEDGPKEEHYECEPVQYACGVRLRRKINIDRNRNASVISRTVPISKDWNITVWEWEKPAAVVETYWQVEQQGLALTAASYSPSRQTLLDPFGLISWPGAVVAAQEMQEYEHLIRGKKVLILGSGVGIEAQAAASLGAGSVLATDIHPTTLKLLEYGAKEAGFRGVISTRVLDLFSVEPLPDCDFMIVADVLYNDRLGAQVAKRCLEVRKNNSSTVVLIADSQRFVREFEKDLNQGFRALEQPRVAWVSRWLPQFTGSGVLIDTDQTYSVKARIIWIGLNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7A5</accession>
    <name>B7G7A5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HemF_1</name>
        <name evidence="7" type="ORF">PHATRDRAFT_15068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CM000619">
        <property type="protein sequence ID" value="EEC45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002182874.1">
        <property type="nucleotide sequence ID" value="XM_002182838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7A5"/>
    <dbReference type="FunCoup" id="B7G7A5">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G7A5"/>
    <dbReference type="PaxDb" id="2850-Phatr15068"/>
    <dbReference type="GeneID" id="7203704"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_15068"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_2_1"/>
    <dbReference type="InParanoid" id="B7G7A5"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="304" mass="34819" checksum="40608ED0677655E6" modified="2009-02-10" version="1">MRSRFEKLCREAQISITKAIEEIDGEGVFREDCWTRANGGGGMSRVLSGGKVFEKAGVNLSVVYGSMPQEALQAATERGVDRAKGMAPGERVPFFACGLSSVMHPKNPHAPTMHFNYRYFETDGGVWWFGGGTDITPSYLNEDDMKHFHGTYKEVCDKHDPEYYEEFKAWADRYFVIQHRNETRGLGGIFFDDQNNKTPDEHFAFSEEAVNSVIKAYGPIVEKHKDDPYTEKQKQWQLMRRGRYVEFNLVYDRGTVFGLKTGGRIESILMSLPETARWEYDHQVEPGSPEAEFLEACRHPRSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2023-11-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7E8</accession>
    <name>B7G7E8_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_48696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183262.1">
        <property type="nucleotide sequence ID" value="XM_002183226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7E8"/>
    <dbReference type="PaxDb" id="2850-Phatr48696"/>
    <dbReference type="GeneID" id="7194682"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48696"/>
    <dbReference type="HOGENOM" id="CLU_382868_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7E8"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC45480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="853" mass="98346" checksum="D8D52862CD24CCA8" modified="2009-02-10" version="1">MDLVFSFVSRNYKRGRPFLEIGLGLFDRCGIENTKTLTVSDEPNHIGIPRRFFRAAYDLQVTCRVWAGYNVLADTIAMRQNSYNFTCIVRTRLPTALRQSDPHIAVHCRQQEKSSPTEWQHAVDMVLQKHLAAGHSKASVEEDATTLFKTFLTPEMATAMQLLPPKVTKAFRSFLKRSRTCCTRNHPHDDFQNPPDFAQFLKAARGDPWAASKRLASYWTEREMMFGSQQEHTYGPSSGWLSKREKDALKSNFLVILPMSEARSLPVLFWDPWCSPFEGREDALSQRRVLFYMLAILSEQGNESIRILIREDIAACSSFQEVDQALYHTLTSWIGSILPLTVQDIHVCSFHDGKKSWLWKSTGLSSVWGSQAHIHDYDSAVQLCKILEQNSFRRAYLPTSLGGGWRSTHNKANSLPESALSRHRRSFDRILMLIPQKEKLGYLQAIRRAPLLVEEESPPELFIRHERNHSMKAVRRFLTYWEERVKIYEDRVFLPIVQTGEGALGPAELEAWKTRYLVDLPQDECGRGSLCYSPGRITIEGPERLRCAFYAFSLLMQNERSLDEGFLVVAMFDNPGFYRATGRTKPADLLRRAFPCRLRELHLVQCLHSGEKFSFFKRLVPTIIGLYAFDHFKIHSGYSRWEIREILEANNLRAHRFPEWLGGELTIQKLDEIECVRAVEEKERCSKQNWPVRRSTGRRGAKLKVVPETELDHLTHDERKRKMDAIYSKRKRARRKAKYGALQEEFSTELIMNMSLRSEEKRLEDLLKQANQIVAVDHQLSVANESVPSILESIAHEQLVAEFLKEHTLQSLVTPVGHLKSYNSSDLITAETTFMDTAFESLTSWMDYAVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B7G7H5</accession>
    <name>B7G7H5_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_48502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000620">
        <property type="protein sequence ID" value="EEC45365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183147.1">
        <property type="nucleotide sequence ID" value="XM_002183111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G7H5"/>
    <dbReference type="STRING" id="556484.B7G7H5"/>
    <dbReference type="PaxDb" id="2850-Phatr48502"/>
    <dbReference type="GeneID" id="7194695"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_48502"/>
    <dbReference type="eggNOG" id="ENOG502SE6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357713_0_0_1"/>
    <dbReference type="InParanoid" id="B7G7H5"/>
    <dbReference type="OrthoDB" id="49257at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC45365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="78589" checksum="EB89C756F16EB111" modified="2009-02-10" version="1">MGKGKAKASKSANRKGSKKPASTPSTARHTHAKPGIGSLFGPIRVRSKRKGETLELNFPSKKTQHLLKAVHPGKLSWKIGKKSKNEDSYKKKAARPTFVLNLPESIGHPQSVPWMKLSRTRNRSSPGSEGLSKCSRGPGHIIPSDALPEETKLKLDKELESFANYVRLTDEECQIRDYLVEQVELICRDLFEESRHTLFNRNSEAMQEAVRVQVFGSFGTKAVCSFRSDVDLAIWGVVPVQKRRPAIMSKKNSQVTHSEKVDCAKQERKRKWQEALAAVDEANTMSPDPMTRQNHSLSNEDGPPLSFAPDNEPERAGVIDQEESLFVIDRFGDVRSIDRLNLPKTSSINSSSSVSLSQTIGDNSGVIKSQGHFLQSQKAESHFKANSENPIDDLNDKAAKPKRAKPKPVESDDESFNDSTDKMEAFVPNRAKSEDRHFVSYSSDDDSHDGFGEEVSEGAGKSDRDLEVSFFSQDSTSKRLGPTGLARQHVTTCLGLIRRKLQKRKFARSTLFIKTADIAIGGHNGSDTSPYAGSQTEKYRSFAPVVLALKVVLQQTNLDEPFAGGLGSYKLYVLVAYHIEQHLLLGGNDRPSEIFLGFLFRYGAILGYNSLDGTMTHLQKNVPVATFDASIADLSNVFLLEHCVDLFGRCWRRLWKRTRSSSKNIGSFLADIVDVKALAKERQSHIQRAKATLCHELAKNNIQHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B7G8M0</accession>
    <name>B7G8M0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHATRDRAFT_7337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000621">
        <property type="protein sequence ID" value="EEC45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183494.1">
        <property type="nucleotide sequence ID" value="XM_002183458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G8M0"/>
    <dbReference type="STRING" id="556484.B7G8M0"/>
    <dbReference type="PaxDb" id="2850-Phatr7337"/>
    <dbReference type="GeneID" id="7194945"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_7337"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_2_0_1"/>
    <dbReference type="InParanoid" id="B7G8M0"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEC45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="90" mass="9997" checksum="81963024F4F89760" modified="2009-02-10" version="1" fragment="single">FVINATIGNIISLSGSFFLSGPHAQLQKMWHETRRVATAVYLASLILTLLIAFGKPPGPNAFYLLVLMACQYVTITWYCLSYIPFARDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B7G933</accession>
    <name>B7G933_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_22896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2024" name="BMC Biol." volume="22" first="136" last="136">
            <title>A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo.</title>
            <authorList>
                <person name="Chen C.C."/>
                <person name="Huang Y.R."/>
                <person name="Chan Y.T."/>
                <person name="Lin H.Y."/>
                <person name="Lin H.J."/>
                <person name="Hsiao C.D."/>
                <person name="Ko T.P."/>
                <person name="Lin T.W."/>
                <person name="Lan Y.H."/>
                <person name="Lin H.Y."/>
                <person name="Chang H.Y."/>
            </authorList>
            <dbReference type="PubMed" id="38867239"/>
            <dbReference type="DOI" id="10.1186/s12915-024-01933-x"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002183697.1">
        <property type="nucleotide sequence ID" value="XM_002183661.1"/>
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    <dbReference type="PDB" id="8HAC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="A/B=1-349"/>
    </dbReference>
    <dbReference type="PDB" id="8HAD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.81 A"/>
        <property type="chains" value="A/B=1-349"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G933"/>
    <dbReference type="SMR" id="B7G933"/>
    <dbReference type="FunCoup" id="B7G933">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7G933"/>
    <dbReference type="PaxDb" id="2850-Phatr22896"/>
    <dbReference type="GeneID" id="7195386"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_22896"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="InParanoid" id="B7G933"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ATPase ASNA1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Asna1_Get3"/>
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        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
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        <property type="entry name" value="ATPase_ArsA/GET3"/>
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    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="260"/>
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        <ligand>
            <name>ADP</name>
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            <position position="260"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="322"/>
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            <name>ADP</name>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
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        <ligand>
            <name>ADP</name>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8HAC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8HAD"/>
        </source>
    </evidence>
    <sequence length="349" mass="38801" checksum="4F9350C2B9EE50C7" modified="2009-02-10" version="1">MDDLDLPDPSLKNIIDQTTLQWVFVGGKGGVGKTTTSCCLGVQLAKSRTKVLLVSTDPAHNLSDAFCQKIGREPTPIHGFDNLCAMEIDASQEAESEIEATDDNDVFGQMFNDLQNSIPGIDEAMSFSELMKQVQQLDFDVVVFDTAPTGHTLRLLSFPTILEKAFAKVWELKDRFGGLIGQATALMSGGNNPAAAQEQLLGKLEETRAVINKVNQAFQDPTKTTFVCVCIPEFLSIYETERLVQELSKYGIDSHNIVVNQVLFPEKDAEELSAWYEANGATLPKEAREICSKLLARKRMQDKYIGQCFDLYGDDFHVVLMPLLDYEVRGVEKLKTFSELLVDPVDMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9E1</accession>
    <name>B7G9E1_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_49071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183760.1">
        <property type="nucleotide sequence ID" value="XM_002183724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9E1"/>
    <dbReference type="PaxDb" id="2850-Phatr49071"/>
    <dbReference type="GeneID" id="7195313"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49071"/>
    <dbReference type="eggNOG" id="KOG3700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379706_0_0_1"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="266"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC44942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="730" mass="80843" checksum="62C14C05F5DB965A" modified="2009-02-10" version="1">MASSETAVLEDVHDPYSWSTSLGSTPPLLTSAACTGSLATFFSDASALSVATEASSHPSGLEALYAQPWVYAGGGLGNIDECSLQTCLAGAGVRRDSITFAAVCVVPECSAFDLAADDFVSTVARVSAGESSVDPPLAQEYVTLLDRIADLNKFLQTGWICGDFTVPWSLVPFGIIFIAVILLLLIFSMVGTLSRQRRNFSKSANNGTVKGAETSNSLEASSSREKVENDGDIGGLLFTNPIWSSFDMSRHVRRLNRQHSTETAVLDGLRVGSISWIMLGHSMAIMSTSGAGYSNPANFLPPHGLTTTVAGQLLFSSRLAVDTFLCISGFLMVHVVDRKMPRRNSRPVVWRYLTNIPSLFFARVVRILPVYAACLGFYTQIAPHLGSGPFWYQWLALLKPCHDYGWTNFLFVNNFVPLDLAITETCFYHSWYLAVDVQLFVVGIFLVFWYQSNSMHGRRVTLSLALLSVLITMYLSYNRRWSVNTFDGAAVARFDVEAYAKPHIRAQAYFAGMYVAMLLPTSVLRQRSSWTWRLHLAMAVALVCMALVTFGTAAGAYARRPCQYTEWPEVDHCGSSWSRNVTFLYTALGRTVWIAGVAVLLYICVGRNSERSLLASVLSWKCWTALSQLSFGAYLIHPIVIFVWQLADRQKEQFRLLTFGMNYLSVCVVSYVLALATALIIEFPCADLWQHFLRNWNRTSPSRNPPIYQSGCEANEIVQLTRSGRYGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B7G9I6</accession>
    <name>B7G9I6_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_49109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000622">
        <property type="protein sequence ID" value="EEC44962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002183780.1">
        <property type="nucleotide sequence ID" value="XM_002183744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7G9I6"/>
    <dbReference type="PaxDb" id="2850-Phatr49109"/>
    <dbReference type="GeneID" id="7195333"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49109"/>
    <dbReference type="HOGENOM" id="CLU_1997025_0_0_1"/>
    <dbReference type="InParanoid" id="B7G9I6"/>
    <dbReference type="OrthoDB" id="50446at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC44962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="125" mass="14512" checksum="FF620B84E3449926" modified="2009-02-10" version="1">MKDMGEKHVSKDECMILNDILGIKTLSGCYAMNRNDLEDNFTIPGENKFEGKDAQLYRNSWLMPRMARRLTRNNKHHVSNWRQDPIIDDAECARLRLLLTNKLDTSEQVHINLPKACRDSKPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAA8</accession>
    <name>B7GAA8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_52547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000623">
        <property type="protein sequence ID" value="EEC44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184040.1">
        <property type="nucleotide sequence ID" value="XM_002184004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAA8"/>
    <dbReference type="STRING" id="556484.B7GAA8"/>
    <dbReference type="PaxDb" id="2850-Phatr52547"/>
    <dbReference type="GeneID" id="7195504"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_52547"/>
    <dbReference type="eggNOG" id="KOG0607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291604_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAA8"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="310" mass="35320" checksum="304CFCD1B51D5182" modified="2009-02-10" version="1" fragment="single">MKDLNDNFAGFLERNENGQSRLTKSNTTGPRTSSKRFEEDSKSGRPFADFWTLGETLGEGGYACVFRARHIRSGDIYAVKDIDTAALEKNSRNALKDEIAAMKLLRGGPHIIRLLDVFEEPDHTFMVMEECRGGDLLTRITEKEVYTERECRKTCKILFQAMDYIHKKKVAHRDIKPENVLMVEPDDDHSIKICDFGFAKRVTKPLCLRTLCGTAQYVAPEVLDLQSAGYDFRADMWSVGVVVYILLGGYAPFEGPVQELARAICKGDYYFHDKYWAEISEFAKDMISSLLQVDCHKRLSAEEALQCPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAD6</accession>
    <name>B7GAD6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_49372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184057.1">
        <property type="nucleotide sequence ID" value="XM_002184021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAD6"/>
    <dbReference type="STRING" id="556484.B7GAD6"/>
    <dbReference type="PaxDb" id="2850-Phatr49372"/>
    <dbReference type="GeneID" id="7195884"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49372"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_1"/>
    <dbReference type="InParanoid" id="B7GAD6"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007825">
        <property type="entry name" value="PRK10534.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="400" mass="43834" checksum="72365DADDBC48B6E" modified="2009-02-10" version="1">MFVSSWKPPIRLGCSKVRCLLSARNRPLVVNSKRRAFLHANCPRFASALIDLRSDTVTKPSRPMLEAALSARTGDDVMGEDPTVLELEETVADLFRKEKGLYVPTGTMSNLVAIMSHCNRRSSEIIIGANCHICLWEGGNTAGLGGVHTRQLLEDETTAQIHRDHISDAFRSDDDDHFAKTELLCLENSHNMMGGVALPLSYVEDIGHLTTELGIKLHIDGARIFNASVCHNVPVDNLCKPADSVSVCLSKGLGAPLGSVLVGDTDFIRLAKRARKRCGGGMRQAGVVAAMGLYAIHNNISRLEADHRRAKRLANELQKNGFYLARNGAVDTNMFYFGLPDNSKVEWKDYCKILQTKHGVGLTGGYSRGGRLFRAVTHLDISDKDIDRAVEAMVLAARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAU0</accession>
    <name>B7GAU0_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATRDRAFT_49502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184136.1">
        <property type="nucleotide sequence ID" value="XM_002184100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAU0"/>
    <dbReference type="STRING" id="556484.B7GAU0"/>
    <dbReference type="PaxDb" id="2850-Phatr49502"/>
    <dbReference type="GeneID" id="7195727"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_49502"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534707_0_0_1"/>
    <dbReference type="InParanoid" id="B7GAU0"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002853170" description="Mitochondrial carrier protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEC44314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57801" checksum="8DFEFBA0C4937913" modified="2009-02-10" version="1">MPFMVSPGTVLLLLGVLSRNVSLASLDPSHFQSYSFHVAQESPATETPTDSTDSDETVRKQQTPSLARHQINDGEDDSRQPNVVASSLLMYEKGCVVSSSEVYPGSTPLDTADDTETSLHKQAYTEIWSLEDEELWREYEDDEDEDDDNDDGHSSMLSNASVKRTRTRARISTNRGTREALASSTNTHLPSPVTSATLSALRGGSKGTVSGILGSEVVKRLYVTALVTLVFEALVGHILEFFKIVMQTRDDGSSYGTVVREITLEKGILGLWDGFVPWGVVQAVGKGAVFGLAHAAAKDLLVPLAQDGMLPMAAALTLAGGIGGGFQGYVLSPTLLLKTRVMTNPVFREPMSLWRTVYLSMRIGFDVVQTEGFWTLMKGANVFATKRVFDWASRYFFADWLEQVFIQLKNGQPLTIAEKSAASLLGGVASTCVTLPLDVLVAKTQDAKKAGVKVSAWTLFRDELREKGLSGLKDSYMRGFEARLLHVCLTTLGTYSWWNVSWKDDLSRLFAIAMNKISNLGISIASLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B7GAY9</accession>
    <name>B7GAY9_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">COPdelta</name>
        <name evidence="14" type="ORF">PHATRDRAFT_30436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000624">
        <property type="protein sequence ID" value="EEC44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184276.1">
        <property type="nucleotide sequence ID" value="XM_002184240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GAY9"/>
    <dbReference type="FunCoup" id="B7GAY9">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B7GAY9"/>
    <dbReference type="PaxDb" id="2850-Phatr30436"/>
    <dbReference type="GeneID" id="7195866"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30436"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B7GAY9"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="273"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEC44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="512" mass="54759" checksum="9DBAE5388B83D4DE" modified="2009-02-10" version="1">MVVLSASVCTRQGKALVSRQFVEMNRLRVEGLLAAFPKLVGHTSQNHTYVETDSVRYVYQPLENQMYLLMITTKTSNIVQDLGTLRLLAKVVPDICGGLQEHAIHENAFDLIFAFDEVLTSGGYKEDASLSSIRTNLLMDSHEEKIHLALKQSKEDQAKAEMQRQAKTIKERQMAQLRNNMMQGGTGQSQPGYSPYHTPAPAIPEPPKVLAKSGMKLGGGAAGGGLGLGGNGMKKDVMAAMAAEDNLFGGTGAAGGNAFGLSSAPPKQTATPSTPLTLVMEEKVTVQMNREGAVESAEVKGTLTLTANTDAGALALVNVNKAQLPAQFSYATHPKVDKKAYETSGTLTLKGGKGFPLSRGVGILRWSYAGDDVAPLSINCWPEDEGGSINVNIEMELTRKDLVLQDVNILLPLGTTDAPVVESIDGVFKHDSRAGMMCWHFDQVDANTNATASMEFSIPGSDPDAFFPVQVGFRSETLLCPMEITSVTNSQSGAAIPHSMTKSFAPEAYTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBK0</accession>
    <name>B7GBK0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_40610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184544.1">
        <property type="nucleotide sequence ID" value="XM_002184508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBK0"/>
    <dbReference type="PaxDb" id="2850-Phatr40610"/>
    <dbReference type="GeneID" id="7198385"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40610"/>
    <dbReference type="HOGENOM" id="CLU_954618_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBK0"/>
    <dbReference type="OrthoDB" id="55634at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="190" mass="21135" checksum="17ED3F20B5C49533" modified="2009-02-10" version="1">MPPVPSKTVLMHILDNVFVLSEDHPIRLCFSQQSIESMEDFFSFLEDGIDALTFSPTPADESNLLPRRMPMKLGHCWLLQAFFDWQVLLEWEKGSFLENSELAALTKADFTCYRQSAIKKASAASLMPSASTLGVTRKGLTPQDGEDCSKPINFAKLHRIKSKNSCVLKGLPDSTPDNLIGETLPTNSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7GBN7</accession>
    <name>B7GBN7_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000626">
        <property type="protein sequence ID" value="EEC43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184560.1">
        <property type="nucleotide sequence ID" value="XM_002184524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GBN7"/>
    <dbReference type="PaxDb" id="2850-Phatr40489"/>
    <dbReference type="GeneID" id="7198415"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40489"/>
    <dbReference type="HOGENOM" id="CLU_699200_0_0_1"/>
    <dbReference type="InParanoid" id="B7GBN7"/>
    <dbReference type="OrthoDB" id="49562at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="395" mass="43395" checksum="60661431EFB52F51" modified="2009-02-10" version="1">MDDTPRSDFSKAALLSAVRQAAGSTPVRRNKMRSALDAKTAPDKARKLIAPTVKSFALMRQVSRLGMDDPVYTLADRGVPNPANRIYDDMNVVDVPDDVLEQMSIASDPTAAFGNGIDVTVFEKSLGDLQPHFSMSQFSQTESSVPVVPQSPSPRSMATIGSNSYLSHIQQSQMPSSFRRSRPQEITISTEDTRMEDLGASMPSLDVISLDLEEAVFGGMVRKLARTDDSNTSRMNKSADDSMLGVRNSRRGCRRGKSSVSNSMMREAALAMEKDGNTNHQLIADALNNSIQDLRSEGLQVRHVPRRTKSNQEKYEAPDPVFPSNKSVNSASSKSRTLPSIASLFPEENEIFPSKIPLRRRVGVRVIQRKHSGDTDEALVGNPDLFVRSLVKAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD04</accession>
    <name>B7GD04_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_40996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002184966.1">
        <property type="nucleotide sequence ID" value="XM_002184930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD04"/>
    <dbReference type="PaxDb" id="2850-Phatr40996"/>
    <dbReference type="GeneID" id="7198919"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_40996"/>
    <dbReference type="eggNOG" id="ENOG502SMUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105645_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD04"/>
    <dbReference type="OMA" id="MAFISQF"/>
    <dbReference type="OrthoDB" id="200159at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855748" evidence="1">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC43413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="208" mass="22567" checksum="5F6270F145AFE29C" modified="2009-02-10" version="1">MLSRLHSTALLLTAVAGWVLLSSSCVQSFSAPSYSRREAVAASIGWTTAVLSQHSPAWAVAAGPPTKEDLERIRLGHAQIVDLLDNFEAATTVCRENGGECKRDAEPIRKVLGLRSTTDPLFQIEKVFNKVKNMDLDPDALEAFFEASEDWNSAMSLSNSMAFISQFGEYNPGGGKDEVLKYLNESKKQVVVAEKALKTIMGSLGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD76</accession>
    <name>B7GD76_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_41071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185004.1">
        <property type="nucleotide sequence ID" value="XM_002184968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD76"/>
    <dbReference type="STRING" id="556484.B7GD76"/>
    <dbReference type="PaxDb" id="2850-Phatr41071"/>
    <dbReference type="GeneID" id="7198953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_41071"/>
    <dbReference type="eggNOG" id="ENOG502S46S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067675_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD76"/>
    <dbReference type="OMA" id="PCKIFTA"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.110">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002856110" description="Methyltransferase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="342" mass="38459" checksum="7337566BBA886020" modified="2009-02-10" version="1">MTPSLYLPALLFFYSIKAEAWTRAARISRYNARPISTGALQAARSNGFPKKRGPQQSKASPKSDDKPIYSMPALYDLAFGYRSYEDEVTFLLQTHERCTGQTPANILEMAAGPARHALTALQLHDAVQSATCVDLSPEMAAYAKAIADEELPENRKNMFTYIVDDMRYFQLEDASQTFDTAWILLGSLQHLTKNEDVIACLTLVNRHLETGGTLIVELPHPRETFSMVECTRNGWEVPLEDENGEESGELRIVWGDEDDEFNSITQVRNFTVAMELTGVAETDKLQNVREVVPLRLFTAQEIDALARCAGFEMVEMYGSLDEEVKVDDEDLAFRLVSVLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD92</accession>
    <name>B7GD92_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHATRDRAFT_30960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185012.1">
        <property type="nucleotide sequence ID" value="XM_002184976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD92"/>
    <dbReference type="STRING" id="556484.B7GD92"/>
    <dbReference type="PaxDb" id="2850-Phatr30960"/>
    <dbReference type="GeneID" id="7198961"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_30960"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050888_0_1_1"/>
    <dbReference type="InParanoid" id="B7GD92"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEC43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="313" mass="36547" checksum="4ACADA5A73A51231" modified="2009-02-10" version="1">MQHDEMIWSVINHQFCSFKTTIGKALSDKTHFCRHPYSVTGLCNRTSCPLANSKYATIREENGRIHLYMKTVERAHSPKNLWEKIVLSRNYGKALAQLDEHLQFFPKVLMHRNKQRLTKIHQYLIRMRKIELKVRSGRKAKMVGVHRKIDQREERRERKALVAAKIERNIEKELTERLAKGTYGDIYNFPETSYQKALETAEENEEETEAESEEEEEDGLMEYVEDLDSEEEDEIEDDMEDIDYLGGGQWGQASDSDDGGDSKVDDHDQDTDDNSEDNDRKLKKKARRRGPRVEIEYEDEQEGNAPMAAETAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B7GD94</accession>
    <name>B7GD94_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_50193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000629">
        <property type="protein sequence ID" value="EEC43460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185013.1">
        <property type="nucleotide sequence ID" value="XM_002184977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GD94"/>
    <dbReference type="PaxDb" id="2850-Phatr50193"/>
    <dbReference type="GeneID" id="7198962"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50193"/>
    <dbReference type="HOGENOM" id="CLU_751153_0_0_1"/>
    <dbReference type="InParanoid" id="B7GD94"/>
    <dbReference type="OrthoDB" id="43223at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC43460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="369" mass="40998" checksum="06AB8402C4EED9F4" modified="2009-02-10" version="1">MKSTRTLAILSGSTCFARHSFGYFLQYCNPSPLSLSRVRVVTQPSSRCCSAFLTSSNKERVELYSSKVMDFPIKVPSGGDFIGLSATFDTAGNLIPVPEYLIPESLVEWGQAPTCLEVITSETSGPDEESYWNRQVLTIYPETGCAIDNLEVKKTQEQVEDCRIWKNAEETVRVLSVALPNHRQRIEVSFGATVDEAKDHRVRVGINLQHVSDAKLVSDRDAPLPTSRSSWLVVAPIQIIRERQLDKSSSEGTRADGGGLDGRSVSTWLGDNLKHSYKFAEQIVETPWKPLTVNVETAEDEQFSELLLPANITISYTSTVSNEDGLILRIGHVFEETRRHVVKVAVEADGIAISKTWVEEGSYEKGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B7GDI2</accession>
    <name>B7GDI2_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">persulfide dioxygenase</fullName>
            <ecNumber evidence="12">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GLO_1</name>
        <name evidence="15" type="ORF">PHATRDRAFT_16707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="12"/>
    <dbReference type="EMBL" id="CM000630">
        <property type="protein sequence ID" value="EEC43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185135.1">
        <property type="nucleotide sequence ID" value="XM_002185099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GDI2"/>
    <dbReference type="STRING" id="556484.B7GDI2"/>
    <dbReference type="PaxDb" id="2850-Phatr16707"/>
    <dbReference type="GeneID" id="7199032"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_16707"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_0_1"/>
    <dbReference type="InParanoid" id="B7GDI2"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEC43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="229" mass="24886" checksum="5FD3C6765345B26B" modified="2009-02-10" version="1">MQLFDAESSTYTYLLWDKDTKDAILVDPVDTQVDRDIDEATKLNLSLVYGVNTHAHADHITGTHLLKQKISGLKSVIAESSGAKADLHVVAGDRIFFGSRFLSVRSTPGHTKGCTSYVADDESFVLTGDTLLIGGCGRTDFQGGSASTLFDSVQSQLFSLPPTTIVYPAHDYKGRTSSTIEKELDSNPRLGKGKTKKEFIEIMSNLNLAYPKKIDVAVPANMRCGVPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7GE25</accession>
    <name>B7GE25_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_50419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000631">
        <property type="protein sequence ID" value="EEC43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185306.1">
        <property type="nucleotide sequence ID" value="XM_002185270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GE25"/>
    <dbReference type="PaxDb" id="2850-Phatr50419"/>
    <dbReference type="GeneID" id="7199225"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50419"/>
    <dbReference type="HOGENOM" id="CLU_805267_0_0_1"/>
    <dbReference type="InParanoid" id="B7GE25"/>
    <dbReference type="OrthoDB" id="42195at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="181"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="345" mass="39123" checksum="575C5F323662A158" modified="2009-02-10" version="1">MSTFSFTAPTITPSHELDEYNALSASEKQALREDLYGRSSAATDEEDQSYVDSESVRSLPTPEGVAILLVEMEHALLEAVSEPNGEAYREAMRVAPSVVQSESPAYGFLRHTNYDPLSAAESLASYWALRRLLFGAERAYLPMTLQGAMLDRGSSSKEKEYEDIATLEKRTVFVMDKDQHGRPVLFWDRIRSSKRFACRNSVLRCFFYCWQCISTLPEAQKHGCVILMNMKGYDIYEHFDRILSKRAFDIDRRMPIKVRAIHLCTGSGKSVTELILPVLKHMAGPELRLRTKIHAGSKKEICDGFAAFGLRRVHVDAICHGSFHNNETLRAWLHQRRALEEIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B7GEL9</accession>
    <name>B7GEL9_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_50592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000634">
        <property type="protein sequence ID" value="EEC42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185550.1">
        <property type="nucleotide sequence ID" value="XM_002185514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7GEL9"/>
    <dbReference type="PaxDb" id="2850-Phatr50592"/>
    <dbReference type="GeneID" id="7199416"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_50592"/>
    <dbReference type="HOGENOM" id="CLU_514370_0_0_1"/>
    <dbReference type="InParanoid" id="B7GEL9"/>
    <dbReference type="OrthoDB" id="39715at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002855832" evidence="1">
        <location>
            <begin position="21"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="524" mass="56125" checksum="7D69E08E029AF265" modified="2009-02-10" version="1">MRIGSVFALVLYLLRTQIGASDLVYLVEPLLKWQRTLPGGGSINGAYIAPNRNNLFVISSVCTVQALDPRTGESVWTYQPGNPSTCSGGVTFSDGVGTPYLTFIESTINLGPTPFSTQVVILDLNSGVLLAKSAFLSGQGAGEPQTTEDGRYIVATSNTANIGTFVVIDTNAVENGIAPIVFEESNPSGPFSPVGFYHRPTTPIFFGGNTNDVFVWAFDLTQMQLVGTEAIENGQIFSFQFPSNYANNGGGLSVKTLGPKTSWKASTRPLLSNGGKSMHWANSDGRYRVWINRTVDDSPTTVLSLPRGIPTSVSAHAAPVLGQDETNPFVYLLGPNPSVFRSNTNLTTSVGLGVDSLFTGQILLSPKEEYMYIATEGRPETSRGILYQIKNEENSLTVDWLFRAESPMSGDLARSTDGTTIFFGQRDGTVSALEVAEAEEELPSSTPASAPVFAPAVCREIGAICGSTTTERPCCFPWLCDAGVCRVPSSRTDPKTALKSDLTTAGSIGILRPRGTIRRDPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3N6</accession>
    <name>B7S3N6_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHATRDRAFT_bd1168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999262">
        <property type="protein sequence ID" value="EEC42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176174.1">
        <property type="nucleotide sequence ID" value="XM_002176138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3N6"/>
    <dbReference type="STRING" id="556484.B7S3N6"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1168"/>
    <dbReference type="GeneID" id="7205086"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1168"/>
    <dbReference type="eggNOG" id="KOG2502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_845865_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3N6"/>
    <dbReference type="OrthoDB" id="45629at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="1">
        <location>
            <begin position="216"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEC42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="329" mass="36574" checksum="0F2B7B28A3C177DA" modified="2009-02-10" version="1">MKLNQQPAIRTVSFDRMEPDDDTNVPVPMETMEIKHPSKEDKLPCGSFGMMSLAMRVPTKLDYHPRSRLVHGILRYRAAASFVQFPLSRGASTNSTDRAAASSAQLEYAVQHADGTETTVLRAVQRGHTRCYDIYDATSKTTSPIAVLQKSWTNASSIAYALSLVSNDVDDEIPCSNDNHLFTVACIVYTIPSLLSALVDAPARQAEMVLRTETAISHELNHQENDALLQCCQKEWQSSRTLQRLVRGENNSLVALQHKDAYDKGEGRYGLNFCGRGKETSRKNMQLTDAKGRVVAQIAKLERHVYHVDHRAPLSPLQAMGFAIAQCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B7S3X3</accession>
    <name>B7S3X3_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHATRDRAFT_bd1274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999278">
        <property type="protein sequence ID" value="EEC42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176264.1">
        <property type="nucleotide sequence ID" value="XM_002176228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S3X3"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1274"/>
    <dbReference type="GeneID" id="7204825"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1274"/>
    <dbReference type="HOGENOM" id="CLU_1059455_0_0_1"/>
    <dbReference type="InParanoid" id="B7S3X3"/>
    <dbReference type="OrthoDB" id="55282at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEC42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="252" mass="27804" checksum="8CB9327661736AFB" modified="2009-02-10" version="1">MSNLLAEHRQAIALSNMGVSLLEKGLYREALETIKDSVVAIKGLYGSQRCRSQNEHDVPVPLADEVKRAYRRLAQGKREIVSISIEVIADDDGFCSIKNLKKNLTHSSNFSICYPIRIDSFNSDMHCLDFHSGIVLHNFSTAHLCLSRLPELSPNRAQKLRDGAYKVGCLANKTLAKLILDDNEATFCGQVLQETSLFIATLATLKTLVSVLHESGCLREAKAFFQRMLDLQGAVLDVGDVELYCTMAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B7S489</accession>
    <name>B7S489_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHATRDRAFT_bd1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS999284">
        <property type="protein sequence ID" value="EEC42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176356.1">
        <property type="nucleotide sequence ID" value="XM_002176320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S489"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft1404"/>
    <dbReference type="GeneID" id="7204798"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd1404"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_2_1"/>
    <dbReference type="InParanoid" id="B7S489"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEC42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="145" mass="15981" checksum="A6478073E4725AA6" modified="2009-02-10" version="1" fragment="single">MPAKPLGRRRGTKRRVSANEPFRNLMLMLLGIAACLTIGIILAATFFFNGDADTDTSLRHKVQALPHLLRGPNAGIAVPSIESQRRDAGHDDHGVLHDTGAHGDKSDALLLALEQKNQRHDPLTKNAPHHDHQQHLKSYPYALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B7S4L0</accession>
    <name>B7S4L0_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHATRDRAFT_bd611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS999307">
        <property type="protein sequence ID" value="EEC42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176500.1">
        <property type="nucleotide sequence ID" value="XM_002176464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7S4L0"/>
    <dbReference type="STRING" id="556484.B7S4L0"/>
    <dbReference type="MEROPS" id="T01.A14"/>
    <dbReference type="PaxDb" id="2850-Phatrdraft611"/>
    <dbReference type="GeneID" id="7205134"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_bd611"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_1_3_1"/>
    <dbReference type="InParanoid" id="B7S4L0"/>
    <dbReference type="OMA" id="GVTHEEM"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEC42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="130" mass="14306" checksum="3204A950688825C8" modified="2009-02-10" version="1">MSTPSIAQMLSNTLYYKRFFPYYAFNVMGGVDAQGKGAVYSYDAIGSFERSTYSANGSGQAYIIPLLDNVIGNRNRLDEPPNLTAEEVVEILKDAFLSAGERDIYTGDQVEICVVRADSVTTQHFALKAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0T0M0</accession>
    <name>PSAJ_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem I reaction center subunit IX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PSI-J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psaJ</name>
    </gene>
    <organism>
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <geneLocation type="chloroplast"/>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="277" first="427" last="439">
            <title>Chloroplast genomes of the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana: comparison with other plastid genomes of the red lineage.</title>
            <authorList>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Grimwood J."/>
                <person name="Shapiro H."/>
                <person name="Armbrust E.V."/>
                <person name="Bowler C."/>
                <person name="Green B.R."/>
            </authorList>
            <dbReference type="PubMed" id="17252281"/>
            <dbReference type="DOI" id="10.1007/s00438-006-0199-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May help in the organization of the PsaE and PsaF subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PsaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="EF067920">
        <property type="protein sequence ID" value="ABK20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_874360.1">
        <property type="nucleotide sequence ID" value="NC_008588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0T0M0"/>
    <dbReference type="SMR" id="A0T0M0"/>
    <dbReference type="STRING" id="556484.A0T0M0"/>
    <dbReference type="GeneID" id="4524637"/>
    <dbReference type="InParanoid" id="A0T0M0"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chloroplast"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00522">
        <property type="entry name" value="PSI_PsaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002615">
        <property type="entry name" value="PSI_PsaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036062">
        <property type="entry name" value="PSI_PsaJ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002743">
        <property type="entry name" value="PRK02733.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36082">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36082:SF2">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01701">
        <property type="entry name" value="PSI_PsaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81544">
        <property type="entry name" value="Subunit IX of photosystem I reaction centre, PsaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0150">Chloroplast</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0602">Photosynthesis</keyword>
    <keyword id="KW-0603">Photosystem I</keyword>
    <keyword id="KW-0934">Plastid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0793">Thylakoid</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000276084" description="Photosystem I reaction center subunit IX">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00522"/>
        </source>
    </evidence>
    <sequence length="41" mass="4845" checksum="584E0AC65E9D5D5B" modified="2007-01-09" version="1">MENFQKYLSTAPVLLTIWLTFTAGFIIEINRFFPDLLGLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y459</accession>
    <name>B5Y459_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPC11</name>
        <name evidence="12" type="ORF">PHATR_13326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001141">
        <property type="protein sequence ID" value="ACI65418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002185948.1">
        <property type="nucleotide sequence ID" value="XM_002185912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y459"/>
    <dbReference type="FunCoup" id="B5Y459">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y459"/>
    <dbReference type="PaxDb" id="2850-Phatr13326"/>
    <dbReference type="GeneID" id="7204448"/>
    <dbReference type="KEGG" id="pti:PHATR_13326"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="InParanoid" id="B5Y459"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACI65418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="111" mass="12537" checksum="5D5E4BE56E18C28D" modified="2008-11-25" version="1">MWFCPLDGTLLQVQIRSGAVPAENSFFYCSTCPYSCSIDAPRTVKTPTKRKVVDDILGGAAAWENVDRTMAVCPACNHNEAYFMQMQIRSADEPMSIFYKCVQCSHQWNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B5Y513</accession>
    <name>B5Y513_PHATC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHATR_18599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
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                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
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                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CCAP 1055/1</strain>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">CCAP 1055/1</strain>
        </source>
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        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
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                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
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                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
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                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
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                <person name="Wyrwicz L.S."/>
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                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CCAP 1055/1</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">CCAP 1055/1</strain>
        </source>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
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    <name>B5Y5I5_PHATC</name>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
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                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001142">
        <property type="protein sequence ID" value="ACI65659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002186189.1">
        <property type="nucleotide sequence ID" value="XM_002186153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5Y5I5"/>
    <dbReference type="FunCoup" id="B5Y5I5">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="556484.B5Y5I5"/>
    <dbReference type="PaxDb" id="2850-Phatr25856"/>
    <dbReference type="GeneID" id="7203900"/>
    <dbReference type="KEGG" id="pti:PHATR_25856"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_1"/>
    <dbReference type="InParanoid" id="B5Y5I5"/>
    <dbReference type="OMA" id="IDLHYTK"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002838821" description="Clp R domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="88"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACI65659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="997" mass="111674" checksum="54B9FE1975F1723C" modified="2008-11-25" version="1">MTTSQTRLALLLVVVAAAWMEGTSVNAFAPAAYHNNVARAKTSFRPAFPAIPVGHASTPHSFLPQSSAPRKAWTSTTSLRIAAEDFSEDKYTEAAWSSIAGLTKVSDYYSASTFEAPFVLEFMLNPNKHNGGEDADAAKRVVEKILNKAGVNLNRLRCELDEYLAKQPRVSDPTNKIMGRTLQKVLETARNGKQALGDSYVSTEGLVLAMVKEDDKFTREALMRQNVKYTDVLEVVKEMRKKSGPAISRSAESMYDALTKYGVDLTERAEQGKLDPVIGRDDEIRRAIQILSRRTKNNPVLIGDPGVGKTAIAEGIAQRMIDGDVPDSLKNCRLIGLDMGALVAGASMRGQFEERLKAVVEEVTQSDGEIILFIDEMHTVVGAGAAQGSMDASNLLKPALARGQLRCIGATTINEYRKYIEKDKALERRFQQVMIDQPTPEDTVSILRGLKPRYELHHGVRIRDEALLAAAKLSHRYIPDRFLPDKAIDLVDEACAKLNNEITSKPTILDEIDRRIIQLEMERLSLQSDFEKYEEDGNTFKATSENFRLAKIDEELGSLKYEQQELNMKWMAEKGAVDRLKDVKEKIAKVKLDIEKFEREFDLNKAAELKYSDLPPLERELEELENIGQYDLGPGEERMLRDEVVADDIAGVVAVWTGIPPGKLLESERDRILTMGDKLRERLIGQDEAIRVVTEAVQRSRAGLNDPSKPIASLIFLGPTGVGKTECAKALAEFMFDSEDALIRIDMSEYMEKHTVSRLLGAPPGYVGYDEGGQLTDAIRRRPYAVLLFDEMEKAHPDVFNVMLQLLDDGRLTDSKGNTVNFRNTICIFTSNVGSQEILDLNGSSEIGDQEIMRSRVTEAMRERFRPEFLNRIDEHVIFNSLNKNNLRGIVVLEVRRLEKRLEEKQMRLVLREEALDFLAEVGFDPVYGARPLKRTIQRELETVVARGILGGEFVDGDTILVDVVNERLNVRRATNADSLPAVFRRPTEEEEVGMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B7FNS8</accession>
    <name>B7FNS8_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal RNA-processing protein 12-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHATRDRAFT_42570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">CCAP 1055/1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177092.1">
        <property type="nucleotide sequence ID" value="XM_002177056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FNS8"/>
    <dbReference type="STRING" id="556484.B7FNS8"/>
    <dbReference type="PaxDb" id="2850-Phatr42570"/>
    <dbReference type="GeneID" id="7195953"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_42570"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_2_1_1"/>
    <dbReference type="InParanoid" id="B7FNS8"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="9">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="7">
        <location>
            <begin position="389"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="XMAP215/Dis1/CLASP TOG" evidence="8">
        <location>
            <begin position="776"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEC51555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="139599" checksum="4852FF32992B2351" modified="2009-02-10" version="1">MDEVQYSDVLQRLKEGSQKRDPRSVRLAAVTSALVEVVEGDDVTAAKVYARTVTALEGILFSETTSLTESLATQVALLELLATTLPFVTPTAIVSASLTLTSRVLRGVITASQSVSIEGSTMETKDELGGANAALRWTCKAATEVLKRLDGRQKNVDEKVIQQLLLGTLITCMEDRRPKVRKAAQNGVIEVLVMEEPHRCHSAVRKAVSSYAHAEIKKTTESKQNDSLGDLLHLLGFLDRAIPYLAYQKLGSDIMELATALFQVEESTSSMDFVSVKVGQATPKVLVISSSLSVISSLLENTDPERKDVLDGFAPRVLASLIQAKPSLIFRRGYAEFEILQKGRTVFGQALLSACRRVLSSKMDLGAKLLPLSVQMILSIATPNDDESEKNSTVAETLLVELTQLFRESLTSFIQSGAPGLDKCLNDCLHSMQQVISPSFLPSTSISLNCLAVLVQQLWQSPQVPEIIEGLIQCRKESAGDSSSQQAIDDAFSSIVQGVGIEVFWDWIQWNPDSAKTAAGGIRLDRAFILPTMKVAANTADAGGQKLAFFQSRILGLARECDKLAASSKEVKFHQARVVDLWSLLPCFCRRAVDIVASLPALTSVLKKALEDRHYPQLVLFISAGLVSLVSSDGGGISTTQSEILSEAAVELLPVMFKIVALNDKPPTEDLKTQMKMTASEVSERSHQTQSLCEAIAALSRCAPTPFLHGLFKKLMQRLLEEAQSGISDSSKVCAFLCLCQSLVSSRVLDENSISFLYRALKPMIRNDEQDARIQKRAYKVLAEMCECHHSFFFDITRLQETIELLTGTMGTSQIAARHMRLKCMNIIIDGFDDTHSEHVDELMHVLAEILLCLKDPNAKTREAGYQLLLSIAMRKDMAGFLQTVTAALGAETPHMRSAAVMALSRLVFEFGWEDESLHILLPSLLRTVLVLVNENSREVIKSTIGFIRISVAAIPAEQLEPVLPELLGGLLHYHKAKSRFRSKIKIILKKLIKLFGYDALTPYVPETETRLLTHMRKLEERQARRKAEAKAEGRNMDQFDEMFDSDEEDSDDGRTWMSGATGFTKLTARNGGKLRSVARSSDSKMSKATMASRATSTSASKLESSTRLPDETDGDVVDMLDSKFAKRVKFNDQSANSDSDGAMEFDDDGRLIVRDEGAVVALESIDEGRAEQQQKFIGNKRQRLGKLDGVKTKESDVKSKKSGKRGRELGSQYKSKKAGGDVRKKDQKFEPYAFVPLDGKSYSKKNRRGAVEQMSSVVRQGGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP02</accession>
    <name>B7FP02_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHATRDRAFT_8877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002176622.1">
        <property type="nucleotide sequence ID" value="XM_002176586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP02"/>
    <dbReference type="STRING" id="556484.B7FP02"/>
    <dbReference type="PaxDb" id="2850-Phatr8877"/>
    <dbReference type="GeneID" id="7196302"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_8877"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037815_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP02"/>
    <dbReference type="OrthoDB" id="184922at2759"/>
    <dbReference type="Proteomes" id="UP000000759">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEC51085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000759"/>
        </source>
    </evidence>
    <sequence length="114" mass="13045" checksum="92B36E4DA66E3636" modified="2009-02-10" version="1" fragment="single">LAGNTGTSRYMAVEVIRKHPYNCKADIFSFSILLWELMALCKPYDGLVGQQVKECVSVFGERPAIPRTWPTNLRRVLRRGWGESIVDRPFMTEVKDTLMKLHEASSKPTKLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B7FP97</accession>
    <name>B7FP97_PHATC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHATRDRAFT_9490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phaeodactylum tricornutum (strain CCAP 1055/1)</name>
        <dbReference type="NCBI Taxonomy" id="556484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Naviculales</taxon>
            <taxon>Phaeodactylaceae</taxon>
            <taxon>Phaeodactylum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Nature" volume="456" first="239" last="244">
            <title>The Phaeodactylum genome reveals the evolutionary history of diatom genomes.</title>
            <authorList>
                <person name="Bowler C."/>
                <person name="Allen A.E."/>
                <person name="Badger J.H."/>
                <person name="Grimwood J."/>
                <person name="Jabbari K."/>
                <person name="Kuo A."/>
                <person name="Maheswari U."/>
                <person name="Martens C."/>
                <person name="Maumus F."/>
                <person name="Otillar R.P."/>
                <person name="Rayko E."/>
                <person name="Salamov A."/>
                <person name="Vandepoele K."/>
                <person name="Beszteri B."/>
                <person name="Gruber A."/>
                <person name="Heijde M."/>
                <person name="Katinka M."/>
                <person name="Mock T."/>
                <person name="Valentin K."/>
                <person name="Verret F."/>
                <person name="Berges J.A."/>
                <person name="Brownlee C."/>
                <person name="Cadoret J.P."/>
                <person name="Chiovitti A."/>
                <person name="Choi C.J."/>
                <person name="Coesel S."/>
                <person name="De Martino A."/>
                <person name="Detter J.C."/>
                <person name="Durkin C."/>
                <person name="Falciatore A."/>
                <person name="Fournet J."/>
                <person name="Haruta M."/>
                <person name="Huysman M.J."/>
                <person name="Jenkins B.D."/>
                <person name="Jiroutova K."/>
                <person name="Jorgensen R.E."/>
                <person name="Joubert Y."/>
                <person name="Kaplan A."/>
                <person name="Kroger N."/>
                <person name="Kroth P.G."/>
                <person name="La Roche J."/>
                <person name="Lindquist E."/>
                <person name="Lommer M."/>
                <person name="Martin-Jezequel V."/>
                <person name="Lopez P.J."/>
                <person name="Lucas S."/>
                <person name="Mangogna M."/>
                <person name="McGinnis K."/>
                <person name="Medlin L.K."/>
                <person name="Montsant A."/>
                <person name="Oudot-Le Secq M.P."/>
                <person name="Napoli C."/>
                <person name="Obornik M."/>
                <person name="Parker M.S."/>
                <person name="Petit J.L."/>
                <person name="Porcel B.M."/>
                <person name="Poulsen N."/>
                <person name="Robison M."/>
                <person name="Rychlewski L."/>
                <person name="Rynearson T.A."/>
                <person name="Schmutz J."/>
                <person name="Shapiro H."/>
                <person name="Siaut M."/>
                <person name="Stanley M."/>
                <person name="Sussman M.R."/>
                <person name="Taylor A.R."/>
                <person name="Vardi A."/>
                <person name="von Dassow P."/>
                <person name="Vyverman W."/>
                <person name="Willis A."/>
                <person name="Wyrwicz L.S."/>
                <person name="Rokhsar D.S."/>
                <person name="Weissenbach J."/>
                <person name="Armbrust E.V."/>
                <person name="Green B.R."/>
                <person name="Van de Peer Y."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="18923393"/>
            <dbReference type="DOI" id="10.1038/nature07410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CCAP 1055/1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Diatom Consortium"/>
                <person name="Grigoriev I."/>
                <person name="Grimwood J."/>
                <person name="Kuo A."/>
                <person name="Otillar R.P."/>
                <person name="Salamov A."/>
                <person name="Detter J.C."/>
                <person name="Lindquist E."/>
                <person name="Shapiro H."/>
                <person name="Lucas S."/>
                <person name="Glavina del Rio T."/>
                <person name="Pitluck S."/>
                <person name="Rokhsar D."/>
                <person name="Bowler C."/>
            </authorList>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">CCAP 1055/1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000605">
        <property type="protein sequence ID" value="EEC51642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002177179.1">
        <property type="nucleotide sequence ID" value="XM_002177143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FP97"/>
    <dbReference type="STRING" id="556484.B7FP97"/>
    <dbReference type="PaxDb" id="2850-Phatr9490"/>
    <dbReference type="GeneID" id="7196112"/>
    <dbReference type="KEGG" id="pti:PHATRDRAFT_9490"/>
    <dbReference type="eggNOG" id="ENOG502RRCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016642_0_0_1"/>
    <dbReference type="InParanoid" id="B7FP97"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP
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